@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TY96: (2017-12-14 )
MKAADSVFISKTNIRREEMKKLVVGILILASFGLAACGNSNNTSQADTKKSSTQTETTLTITDSNGDQIEVPNNPEKVVVFDNGSLDTMDALGVGDKVVGAATSSLPEYLSSYKKVESAGGIKEPDLEKINQLQPDLIIISGRQRDFQKDLSQIAPTIFLSLDAKNPWESFQQNVTALGEIFGKQEEAKTQLEELSSAIDQTKKKAEATDKKALVTLVNEGQLSAYGSGSRFGFIHDLFGFEQADDQIEASTHGQSVSYEYVLEKNPDILFVVDRTKAIGGDDSKDDISANELVAQTNAGKNQQIISLEPDVWYLSGGGLESMKLMIEDVNQAFK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310...-..-.-.320.......330...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKAA
D
S
V
F
I
SKTNI
R
R
E
E
M
K
K
L
V
V
G
I
L
I
L
A
S
F
G
LAACGNSNNTSQADTKKSSTQ
T
E
T
T
L
T
I
TDSNG
D
Q
I
EVPNNP
E
K
V
V
V
FDNGSLD
T
M
D
ALGVGD
K
V
V
G
A
A
T
S
S
L
P
E
Y
L
S
S
Y
K
K
V
E
SAGGIKEP
D
L
E
K
I
N
QLQP
D
L
I
I
I
SGRQ
R
D
F
Q
K
D
L
S
Q
IA
P
T
I
F
L
S
LDAKN
P
W
E
S
F
Q
Q
N
V
T
A
L
G
E
I
FG
K
Q
E
E
A
K
T
Q
L
E
E
L
S
S
A
I
D
Q
T
K
K
K
AEATD
K
K
A
L
V
T
L
VNEG
Q
L
S
AYGSGSRFG
F
I
H
D
LFGFEQADDQIEASTHGQS
V
S
Y
E
Y
V
LEKNP
D
I
L
F
V
V
DRTKAIGGDDSKDDIS
A
N
E
L
V
AQTNAGKN
Q
Q
I
I
S
LEP
D
V
W
Y
L-SG-G-
G
L
E
S
M
K
L
M
I
E
D
V
N
Q
AFK
13
PsiBlast_PDB
96.81
45%
-88
- C1 -
-
5LWQ
-
?
A:
[15-291]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
L
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
25
PsiBlast_CBE
96.45
45%
-82
- C1 -
-
5ADV
2
?
B:
[11-287]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
H
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
33
HHSearch
96.40
45%
-83
- C1 -
-
5AD1
1
?
A:
[10-290]
-----------------------------------------------------
D
E
G
D
S
F
L
V
K
D
S
L
G
E
-
N
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
E
-
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
H
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
-
A
S
G
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
6
PsiBlast_PDB
95.66
45%
-85
- C1 -
-
5ADV
2
?
A:
[11-287]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
H
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
3
PsiBlast_PDB
95.52
45%
-83
- C1 -
-
5AD1
1
?
A:
[14-290]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
H
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
10
PsiBlast_PDB
95.28
45%
-85
- C1 -
-
5LWH
-
?
A:
[13-289]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
H
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
F
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
7
PsiBlast_PDB
95.10
45%
-82
- C1 -
-
5ADW
3
?
A:
[11-287]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
H
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
8
PsiBlast_PDB
94.94
45%
-80
- C1 -
-
5A5D
1
?
A:
[13-289]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
H
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
23
PsiBlast_CBE
94.77
45%
-80
- C1 -
-
5ADW
1
?
B:
[11-287]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
H
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
22
PsiBlast_CBE
94.73
45%
-81
- C1 -
-
5ADW
1
?
C:
[11-287]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
H
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
26
PsiBlast_CBE
94.64
45%
-80
- C1 -
-
5TCY
1
?
C:
[15-291]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
L
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
14
PsiBlast_PDB
94.42
45%
-81
- C1 -
-
5TCY
1
?
A:
[15-291]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
L
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
27
PsiBlast_CBE
94.07
45%
-81
- C1 -
-
5TCY
2
?
B:
[15-290]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
L
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
-
21
PsiBlast_CBE
93.85
45%
-81
- C1 -
-
2CHU
2
?
B:
[20-296]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
---
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
12
PsiBlast_PDB
93.71
45%
-83
- C1 -
-
5MBQ
-
?
A:
[15-291]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
A
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
---
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
4
PsiBlast_PDB
93.60
45%
-80
- C1 -
-
5A1J
1
?
A:
[12-288]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
H
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
9
PsiBlast_PDB
92.98
45%
-81
- C1 -
-
5A5V
1
?
A:
[13-289]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
H
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
-
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
15
PsiBlast_PDB
92.97
44%
-87
- C1 -
-
5MBU
-
?
B:
[15-291]
---------------------------------------------------------
S
F
L
V
K
D
S
I
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
-
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
V
G
T
A
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
F
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
2
PsiBlast_PDB
92.80
45%
-81
- C1 -
-
2CHU
2
?
A:
[20-296]
---------------------------------------------------------
S
F
L
V
K
D
S
L
G
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
----
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
A
S
G
-
N
-
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
49
Fugue
92.60
43%
-79
* C1 *
-
2CHU
2
?
A:
[10-296]
-----------------------------------------------
L
P
I
S
M
S
D
E
G
D
S
F
L
V
K
D
S
L
G
-
E
N
K
I
P
K
N
P
S
K
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
K
N
L
P
K
Y
L
Q
Q
F
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
N
F
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
-
E
D
K
K
A
L
I
I
L
T
N
S
N
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
----
N
I
K
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
V
D
R
N
V
I
L
G
N
K
E
R
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
P
E
Y
W
Y
L
-
A
S
-
G
N
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K