@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TYB0: (2017-12-14 )
MRKPLFYATITKTFEHKKGGKDVYLSSEYLKQFDKDLYYKILLLESFEDQAWHTAAQLAQVVQLDARSVSKYLNELSKNYQQFSGKTHPLFTKNHRSGYNFYDTLDSIEHERFLIYLVQSTLKFQLLHDIFFEEFHTMYQFAQKHYISESTAHRKINEWKQQLQTYGIRLQRGTYIAQGEEEIIRLYLHMTFWQLFRGKIWPFETISQMDVKNMAEHIMAFFNVRLNEIKKRRLEYMLGAFFLRKSQKHYVVLNEKKRRLISDNLLFQRFCQVMEPVFPNYFQVEDELGALFLVLMTREEYYSDPKIRKKIFDFHQQAKTPPFTALSEAKAALSLYQEEQGLPAENLTFEAENYLFSSHFFAYLFPNAKETIDGNSSDFINHLVIENKELKQWLVHFFESRHKHPNHLAFKNHAFLMGRYLTVFKTLGAFTPQLPKITILLMTDFPLFEEQLLEEGLRTFFRNEYQLIFLPTDYRGREVDLLISTSKVHRKPWADLDYFIVTEELKLIDYIQLSQKFEMIQKQKLLKQ
Atome Classification :
(20 SA)
----------.........10........20..--......30........40.....------..-.50........60........70..----......-80........90........100...---....110------------------........120.....--------------..130.....--..140.......150.......----160..-.....170------.........180.......190-.......200--------.....--....210.-------......220--------------.......230--------------.......240-......----..250----.---........260...----------.---...270......------.--280.......290.......--.300--------------...----------------....310....---------------------------...320.--.----.....330----.........340........350.......360.......370.---......380.......390---------....--....400.-.-..--...410...--..--..420.----......-430.......440-----------...-......450-----....--..----...460-...-..--.--.----.470-.--------.--.....480.......490--------.-----......500...-....--510.......520......---------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------MRKP
L
F
Y
A
T
I
T
K
T
F
EHKKGGK
D
V
--
Y
L
S
S
E
Y
L
K
Q
F
D
K
D
L
Y
Y
K
I
L
L
L
ES------FE-D
Q
A
W
H
T
A
A
Q
L
A
Q
V
V
Q
L
D
A
R
S
V
S
K
Y
L
----
N
E
L
S
K
N
-
Y
Q
Q
FSGKTH
P
L
F
TKNHRSGYN
F
Y
D
T
L
---
D
SIEH
E
-------------------
R
F
L
I
Y
L
V
Q
S
T
L
K
F
Q
L
L
--------------
H
D
I
F
F
E
E
F
H
T
--
M
Y
Q
F
A
Q
K
HYIS
E
S
T
A
H
R
K
I
N
E
W
----
K
Q
Q
L
Q
-TY
G
I
R
L
--------QR
G
T
Y
IAQ
G
E
E
E
I
I
R
L
Y
L
H
M
T
F
-
W
Q
L
F
RGKI----------W
P
F
E
T
--
I
S
Q
M
D
V
K
N
-------
M
A
E
H
I
M
A
F
F
--------------
N
V
R
L
N
E
I
K
K
R
--------------
R
L
E
Y
M
L
G
A
F
--
F
L
RKSQ----K
H
Y
------
V
---
V
L
N
E
K
K
R
R
LISD
N
L
----------
L
---
F
Q
R
F
C
Q
V
M
E
P
VF------P--N
Y
F
Q
V
E
D
EL
G
A
L
-
F
L
V
L
M
T
R
--
E
E
YY--------------S
D
P
----------------
K
I
R
K
K
I
F
D
F
H
Q
---------------------------QAKTPP
F
--
T
----
A
L
S
E
A
K
------
A
A
L
S
L
Y
Q
E
EQG-LPAEN
L
T
FEAENY
L
F
S
S
H
F
F
A
Y
LFPN
A
K
ETID---GN
S
S
D
F
I
N
H
L
VIE
N
K
E
L
K
----------
Q
W
L
V
--
H
F
F
E
S
RHK-H-PN--HLAFKN
H
A
F
--
L
M
--
G
R
Y
L
T
V
----
F
K
T
L
G
A-FTPQL
P
K
I
T
I
L
-------------
L
MT-DFP
L
F
E
E
-------
Q
L
L
E
--
E
G
----
L
R
T
F
F
--RNE-
Y
Q
--
L
--
I
----
F
L
PT-D--------Y--RG
R
E
V
D
L
L
I
STSKVHRKP--------W-----ADL
D
Y
F
I
V
T
E
E
L
-
K
L
I
D
--
Y
I
Q
L
S
Q
K
F
E
M
I
Q
K
Q
K
L
LKQ---------------------------
23
HHSearch
76.36
15%
-29
- C6 -
-
5WAY
1
?
B:
[1-492]
----------------------------------------
M
R
D
L
L
S
K
K
S
H
R
Q
L
E
L
L
E
L
------
L
F
E
H
K
R
W
F
H
R
S
E
L
A
E
L
L
N
C
T
E
R
A
V
K
D
D
L
----
S
H
V
K
S
A
-
F
P
D
L
-----
I
F
H
------
R
I
I
N
T
D
D
S
---
D
---
I
E
-------------------
M
V
Y
H
H
F
F
K
H
S
T
H
F
S
I
L
--------------
E
F
I
F
F
N
E
G
C
Q
--
A
E
S
I
C
K
E
F
Y
I
S
S
S
S
L
Y
R
I
I
S
Q
I
----
N
K
V
I
K
R
Q
F
Q
F
E
V
--------
S
L
T
P
V
Q
I
I
G
N
E
R
D
I
R
Y
F
F
A
Q
Y
F
-
S
E
K
Y
Y
F
L
E
----------
W
P
F
E
N
--
F
S
S
E
P
L
S
Q
-------
L
L
E
L
V
Y
K
E
T
--------------
S
F
P
M
N
L
S
T
H
R
--------------
M
L
K
L
L
L
V
T
N
--
L
Y
R
I
K
F
----
G
H
F
------
M
---
E
V
----------
L
D
----------
F
L
M
Q
A
E
G
I
E
G
V
A
Q
S
F
E
------
S
EY
N
I
S
L
D
E
E
V
V
C
Q
L
-
F
V
S
Y
F
Q
K
--
M
F
F
I
--------------
D
E
S
----------------
L
-
F
M
K
C
V
-
K
K
D
---------------------------
S
Y
V
E
K
S
Y
--
H
----
L
L
S
D
---------
F
I
D
Q
I
S
V
K
Y
Q
--
I
E
I
E
N
K
D
N
L
I
W
H
L
---
H
N
T
A
H
L
Y
R
Q
E
L
F
T
E
F
ILF
D
Q
K
G
N
T
I
R
N
F
Q
N
I
F
P
K
F
V
----------
S
D
V
K
--
K
E
L
S
H
Y
L
E
-
T
L
E
V
--
C
S
S
S
M
M
V
N
H
--
L
S
--
Y
T
F
I
T
H
----
T
K
H
L
V
I
N
L
L
Q
N
Q
P
K
L
K
V
L
-------------
V
M
S
-
N
F
D
Q
Y
H
A
-------
K
F
V
A
--
E
T
----
L
S
Y
Y
C
--
S
N
N
-
F
E
--
L
--
E
----
V
W
T
E
-
L
ELS
K
E
S
--
L
--
E
D
S
P
Y
D
I
I
I
S
N
F
I
I
P
P
----------
I
-----
E
N
K
R
L
I
Y
S
N
N
I
N
-
T
V
S
L
--
I
Y
L
L
N
A
M
M
F
I
R
L
D
---------------------------------
24
HHSearch
75.13
15%
-25
- C6 -
-
5WAY
1
?
A:
[1-492]
----------------------------------------
M
R
D
L
L
S
K
K
S
H
R
Q
L
E
L
L
E
L
------
L
F
E
H
K
R
W
F
H
R
S
E
L
A
E
L
L
N
C
T
E
R
A
V
K
D
D
L
----
S
H
V
K
S
A
-
F
P
D
L
-----
I
F
H
S
S
T
N
G
I
R
I
I
N
T
D
D
S
---
D
---
I
E
-------------------
M
V
Y
H
H
F
F
K
H
S
T
H
F
S
I
L
--------------
E
F
I
F
F
N
E
G
C
Q
--
A
E
S
I
C
K
E
F
Y
I
S
S
S
S
L
Y
R
I
I
S
Q
I
----
N
K
V
I
K
R
Q
F
Q
F
E
V
--------
S
L
T
P
V
Q
I
I
G
N
E
R
D
I
R
Y
F
F
A
Q
Y
F
-
S
E
K
Y
Y
F
L
E
----------
W
P
F
E
N
--
F
S
S
E
P
L
S
Q
-------
L
L
E
L
V
Y
K
E
T
--------------
S
F
P
M
N
L
S
T
H
R
--------------
M
L
K
L
L
L
V
T
N
--
L
Y
R
I
K
F
----
G
H
F
------
M
---
E
V
----------------------
F
LMQ
A
E
G
I
E
G
V
A
Q
S
F
E
------
S
E
Y
N
I
S
L
D
E
E
V
V
C
Q
L
-
F
V
S
Y
F
Q
K
--
M
F
F
I
--------------
D
E
S
----------------
L
-
F
M
K
C
V
-
K
K
D
---------------------------
S
Y
V
E
K
S
Y
--
H
----
L
L
S
D
---------
F
I
D
Q
I
S
V
K
Y
Q
--
I
E
I
E
N
K
D
N
L
I
W
H
L
---
H
N
T
A
H
L
Y
R
Q
E
L
F
T
E
F
ILF
D
Q
K
G
N
T
I
R
N
F
Q
N
I
F
P
K
F
V
----------
S
D
V
K
--
K
E
L
S
H
Y
L
E
-
T
L
E
V
--
C
S
S
S
M
M
V
N
H
--
L
S
--
Y
T
F
I
T
H
----
T
K
H
L
V
I
N
L
L
Q
N
Q
P
K
L
K
V
L
-------------
V
M
S
-
N
F
D
Q
Y
H
A
-------
K
F
V
A
--
E
T
----
L
S
Y
Y
C
--
S
N
N
-
F
E
--
L
--
E
----
V
W
T
E
-
L
ELS
K
E
S
--
L
--
E
D
S
P
Y
D
I
I
I
S
N
F
I
I
P
P
----------
I
-----
E
N
K
R
L
I
Y
S
N
N
I
N
-
T
V
S
L
--
I
Y
L
L
N
A
M
M
F
I
R
L
D
---------------------------------
53
Fugue
74.14
15%
-
- C- -
-
4NLE
-
?
A:
[4-471]
------------------
T
I
P
N
V
L
A
N
R
Y
A
S
D
E
M
V
A
I
W
S
P
E
A
K
I
I
A
E
R
R
L
W
L
A
V
L
R
A
Q
A
E
L
GVAV
P
D
-
G
V
V
E
D
Y
E
R
V
L
E
N
V
D
L
E
S
I
A
A
R
E
R
V
R
----
H
D
V
K
A
R
-
I
E
E
F
N
A
H
E
H
V
------
H
K
G
M
T
S
R
D
L
T
---
E
N
V
E
Q
L
-------------------
Q
-----
I
R
Q
S
L
E
L
V
F
S
--------------
H
G
V
A
V
V
A
R
L
A
--
E
R
A
V
V
Y
R
D
L
V
M
A
G
R
S
H
N
V
A
A
Q
A
----
T
T
L
G
K
-
R
F
A
S
A
A
--------
E
E
T
L
V
A
L
T
R
L
R
E
L
I
D
R
Y
P
--------
L
R
G
V
K
----------
G
P
M
G
T
------------------
A
Q
D
M
L
D
L
F
--------------
G
--
G
D
V
G
K
L
A
--------------
D
L
E
R
R
V
A
E
F
L
G
F
T
E
V
F
T
----
S
V
G
------
Q
---
V
Y
---
P
R
S
L
D
H
D
V
L
S
---------
A
---
L
V
Q
F
G
A
G
P
S
S
M
A
------
H
--
T
I
R
L
M
A
G
H
--
E
L
-
V
T
E
G
F
A
P
--
G
Q
V
G
--------------
S
S
A
----------------
M
P
H
K
M
N
T
R
S
C
E
---------------------------
R
V
N
G
L
Q
V
--
V
----
L
R
G
Y
A
S
------
M
A
A
E
L
A
G
A
Q
W
N
-----------
E
G
D
V
F
C
S
V
V
R
R
V
A
L
P
D
A
F
F
A
I
D
---
G
Q
T
E
T
F
L
T
V
L
D
E
------------------------------------------------
F
G
--
A
Y
P
A
V
I
----
Q
R
E
L
D
R
-
Y
L
P
F
L
A
T
T
R
I
L
-------------
M
A
A
-
V
R
A
-----------
G
V
G
R
--
E
A
----
A
H
E
V
I
--
K
E
H
-
A
V
--
A
--
V
----
A
L
A
M
-
R
--------
E
--
Q
G
R
E
P
D
L
I
D
R
L
A
G
D
P
R
L
P
--------
L
-----
D
K
V
A
L
E
A
A
L
E
D
K
-
Q
A
F
T
--
G
A
A
G
D
Q
V
D
G
V
V
A
A
V
G
E
L
V
S
R
Y
PEAAKYTSG----------------
21
HHSearch
63.72
14%
-21
- C6 -
-
4R6I
1
ATXA_BACAN
B:
[9-476]
-------------------------------------------
S
I
E
K
E
H
I
R
L
I
N
L
L
H
F
------
I
N
E
Q
N
R
W
F
T
I
K
E
L
S
D
Y
L
Q
V
A
D
K
T
V
R
K
Y
L
----
K
L
L
E
D
E
-
I
P
P
S
W
--
N
-
L
L
V
Q
K
G
K
G
I
Y
L
K
K
P
L
N
E
---
S
---
L
S
-------------------
F
V
E
S
K
I
L
R
K
S
L
N
L
Q
I
C
--------------
E
E
L
V
F
K
K
-
N
S
--
M
Q
S
L
A
Q
K
L
H
L
Q
V
G
A
L
Y
P
I
I
N
Q
I
----
N
Y
D
I
Q
-
S
S
H
L
N
I
--------
K
K
K
P
L
E
I
S
G
R
E
Q
D
V
R
V
F
M
L
R
L
Y
-
C
N
I
-
P
N
D
Y
----------
W
P
F
P
Y
--
I
N
K
Q
N
I
T
D
-------
L
I
N
K
M
E
K
I
L
--------------
N
V
Q
M
Y
T
Y
S
K
H
--------------
K
L
C
V
L
F
A
I
T
--
I
S
R
L
L
S
----
G
N
T
------
I
---
D
N
V
S
G
L
I
L
V
N
K
N
D
D
----------
H
---
Y
K
T
V
A
S
I
T
S
E
L
Q
------
N
S
F
G
V
T
L
H
E
T
E
I
S
F
L
-
A
L
A
L
L
L
S
--
L
G
N
S
--------------
I
T
-------------------
N
K
T
----
L
T
---------------------------
S
Y
K
K
T
I
M
--
P
----
L
A
K
E
I
---------
T
K
G
I
E
H
K
L
Q
L
G
I
N
Y
D
--
E
S
F
L
T
Y
-
V
V
L
I
I
K
K
A
L
D
K
N
F
I
Q
Y
Y
N
---
Y
-
N
I
K
F
I
R
H
I
K
Q
R
H
P
N
T
F
----------
N
T
I
Q
--
E
C
I
S
N
L
N
Y
T
V
-
Y
S
--
H
F
D
C
Y
E
I
S
L
--
L
T
--
M
H
F
E
T
Q
----
R
M
L
------
F
K
N
N
P
K
K
I
Y
-------------
V
Y
T
-
S
Q
G
C
I
H
R
-------
E
Y
I
S
--
A
L
----
L
E
K
R
Y
--
N
G
L
-
I
K
--
I
--
V
----
R
N
T
I
--------------
D
M
E
I
D
I
I
I
S
N
------------------------------
E
F
P
-
T
E
R
D
--
F
H
E
I
K
K
----------------------------------------
49
Fugue
62.69
17%
8
- C5 -
-
3VSM
1
OE66_NPVAC
A:
[27-659]
--------N
I
Q
E
L
Q
N
F
E
R
W
F
K
N
N
L
S
Y
S
F
S
Q
K
A
E
--
K
V
V
N
-
P
N
R
N
W
N
D
N
T
V
F
D
N
L
--------------
S
P
W
T
S
V
P
D
F
G
T
V
C
H
T
L
I
G
Y
C
V
R
Y
N
----
N
T
S
D
T
L
-
Y
Q
------------
N
P
E
L
A
Y
N
L
I
N
G
L
---
R
I
I
C
S
K
LPDPPPHQQAPWGPVADWY
H
F
T
I
T
M
P
E
V
F
M
N
I
T
I
V
L
N
------------
E
T
Q
H
Y
D
E
A
A
S
--
L
T
R
Y
W
L
G
L
Y
L
P
T
A
V
---
N
S
M
G
W
----
H
R
T
--------------------------
A
G
N
S
M
R
M
G
V
P
Y
T
Y
-
S
Q
M
L
R
G
Y
---------------
S
--
L
A
Q
I
R
Q
E
Q
-------
G
I
Q
E
I
L
N
T
I
AFPYVTQGNGLHVD
S
I
Y
I
D
H
I
D
V
R
--------------
A
Y
G
Y
L
I
N
S
Y
--
F
T
F
A
Y
Y
----
T
Y
Y
------
F
GDE
V
I
N
T
V
G
L
T
R
A
I
E
N
V
GSPEGVVVPG
V
---
M
S
R
N
G
T
L
Y
S
N
V
I
------
G
--
N
F
I
T
Y
P
L
A
V
H
S
A
D
Y
S
K
V
L
T
K
L
S
K
T
Y
Y
G
S
V
V
G
V
T
NRLAY
Y
E
S
D
P
TNNIQ
A
P
L
W
T
MAR
R
I
W
N
R
R
G
R
I
I
N
Y
N
A
NTVSFESGIILQSLNG
I
M
R
I
P
S
GTT
S
T
Q
S
F
R
P
T
I
G
Q
T
----
A
I
A
K
T
D
------
T
A
G
A
I
L
V
Y
A
K
F
-
A
E
M
N
N
L
Q
F
K
S
C
T
L
F
Y
D
H
G
M
F
Q
L
Y
Y
N
I
G
V
E
P
N
S
---
L
N
N
T
N
-
G
R
V
I
V
L
S
R
D
T
S
V
----------
N
T
N
D
--
L
S
F
E
A
Q
R
I
-
N
-
N
N
--
N
S
S
-
E
G
T
T
F
NG
V
V
--
C
H
R
V
P
I
T
N
I
N
V
P
S
L
T
V
-
R
S
P
N
-
S
S
V
E
L
V
-------------
E
Q
I
I
S
F
Q
T
M
Y
T
AT
A
S
A
C
Y
K
L
N
V
--
E
G
HSDS
L
R
A
F
R
--
V
N
S
-
D
E
--
N
--
I
----
Y
V
N
V
--------------
G
N
G
V
K
A
L
F
N
Y
P
W
V
M
V
K
E
--------
N
-----
N
K
V
S
F
M
S
A
N
E
D
--
T
T
I
P
--
F
S
V
I
M
N
S
F
T
S
I
G
E
P
A
L
Q
Y
S
P
SNCFVYGN
G
F
K
L
NNSTF
D
L
Q
F
I
F
E
I
V
52
Fugue
56.34
16%
-19
- C3 -
-
4R12
5
?
A:
[15-587]
-----------
Y
T
T
L
Y
S
S
Y
P
C
T
K
I
M
T
S
D
G
------
Q
F
G
C
S
S
K
H
G
G
N
S
G
I
L
Y
L
I
D
D
D
E
S
------
Y
N
-
N
Y
-
F
S
Y
S
Q
Q
K
D
I
I
V
V
L
D
T
N
Y
F
N
S
T
S
----
V
L
N
L
H
N
-
K
S
K
I
E
G
---
I
I
V
L
T
D
T
K
K
T
Y
P
Y
--
S
P
---
D
S
R
Y
P
N
-------------------
K
I
Y
G
L
Y
P
N
S
N
L
E
W
N
P
N
--------------
A
D
G
F
T
Y
F
S
F
P
--
F
P
I
F
A
I
D
N
Q
T
S
V
A
I
R
N
V
S
K
H
N
R
----
D
G
Q
Y
P
-
A
W
G
A
E
L
D
S
F
M
QGAI
N
S
E
T
C
L
R
R
G
F
C
E
P
V
G
---
G
Q
S
I
-
W
S
S
F
S
S
K
I
DKE
K
E
I
I
L
V
M
L
P
F
D
T
--
T
A
F
F
R
D
L
S
IGADQS
S
F
A
T
V
T
L
L
S
V
--------------
I
K
S
L
A
A
V
D
R
S
SWN
K
E
V
V
F
A
F
W
N
AE
R
W
G
Y
V
G
S
E
Y
--
F
I
N
D
L
L
N
F
Q
C
K
T
Y
NSDKSK
C
---
I
D
P
P
R
A
D
L
A
F
Q
T
Q
I
----------
N
---
F
T
K
I
S
T
I
I
E
L
N
Q
------
I
--
G
R
A
Q
L
D
K
N
L
G
K
Y
-
S
L
Y
L
H
T
A
--
G
T
----------------
K
T
S
----------------
S
V
T
D
I
L
D
Q
V
A
S
---------------------------
S
Y
E
N
S
T
I
--
T
----
F
K
P
T
T
Q
TELPPS
S
S
M
S
F
L
K
K
T
N
K
-
I
P
V
V
V
I
T
--
D
H
D
Y
K
Y
S
N
P
Y
Y
G
Y
---------
E
---
Q
D
D
N
E
N
V
L
G
S
T
L
N
--
D
I
V
----------
Y
I
L
S
--
T
F
I
D
R
I
A
G
-
G
-
N
N
--
N
I
T
I
-
D
K
N
F
--
I
N
--
I
L
Y
P
C
F
----
T
S
S
I
T
C
-
F
N
I
L
M
K
T
Y
P
L
N
EVPNFYSSVFGTS
L
T
T
-
T
L
S
P
Y
E
T
-------
K
L
I
H
--
R
L
----
L
Y
S
I
T
--
Q
Y
N
-
S
T
--
L
--
T
----
N
C
T
S
-
D
NDCPS
S
L
C
Y
--
S
G
Q
C
V
S
---
S
N
T
H
L
H
N
A
L
--------
S
-----
L
G
F
D
F
D
T
S
K
N
V
W
-
K
I
V
N
SS
Y
P
I
F
T
E
S
N
W
D
Y
T
A
L
K
V
F
K
I
---------------------------
47
Fugue
50.44
18%
18
- C1 -
-
5LJX
2
A:
[6-415]
T
P
V
W
N
DNAH
G
V
G
S
V
P
M
H
T
D
L
E
L
D
F
S
L
T
S
S
S
K
Y
T
--
Y
R
R
K
L
T
N
P
A
Q
S
I
D
L
H
I
E
I
E
-----------------------
E
Q
T
I
G
V
D
V
H
A
L
G
---------------
H
W
F
D
G
R
L
N
--
L
K
T
S
F
K
Y
E
Y
P
W
H
T
A
K
---
C
H
Y
E
R
D
----------------------------------------------------
Y
Q
Y
E
G
C
T
--
A
C
G
L
Y
L
D
Q
L
K
P
V
G
S
A
Y
K
I
I
T
---------------
I
R
Y
--------
S
R
R
V
C
V
Q
F
G
E
E
N
L
C
K
I
I
D
M
N
D
C
-
F
V
S
R
H
V
K
V
----------
C
I
I
G
T
--
V
S
K
F
S
Q
G
D
-----------
T
L
L
F
F
--------------
G
----------------------------------------------------------------
P
L
E
G
G
G
L
----------
I
---
F
K
H
W
C
T
S
-------------------
T
C
Q
F
G
D
P
-
G
D
I
M
S
P
R
--
D
K
G
F
--------------
L
C
P
----------------
E
F
P
G
---
S
F
R
K
---------------------------
K
A
T
T
P
I
C
--
E
Y
DGN
M
V
S
G
Y
K
------
K
V
M
A
T
I
D
S
F
Q
S
-
F
N
T
S
T
M
H
F
T
D
E
R
I
E
W
K
D
P
-------------
D
---
G
M
L
R
D
H
I
N
I
L
V
T
K
D
I
D
--------------------
F
D
N
L
G
E
-
N
-
P
C
--
K
I
G
L
Q
T
S
S
I
--
E
-----------------
G
A
-
W
G
S
G
----------------------
V
-
G
F
T
L
T
C
L
-------
V
S
L
T
--
E
------
C
P
T
F
--
L
T
S
-
I
K
--
A
--
C
----
D
K
A
I
-
C
--------
Y
--
G
A
E
S
V
T
L
T
R
G
Q
N
T
V
K
V
S
G
K
G
G
-----
H
-----
S
G
S
T
F
R
C
C
H
G
E
----------
D
C
S
Q
I
G
L
H
A
A
A
P
H
L
------------------------------
2
PsiBlast_PDB
49.91
22%
0
- C- -
-
5WAY
-
?
A:
[20-228]
----------------------------------------------------------------
F
E
-
H
K
R
W
F
H
R
S
E
L
A
E
L
L
N
C
T
E
R
A
V
K
D
D
L
----
S
H
V
K
S
A
-
F
P
D
-------
L
I
F
H
S
S
T
N
G
I
R
I
I
N
T
D
---
D
S
-
D
I
E
-------------------
M
V
Y
H
H
F
F
K
H
S
T
H
F
S
I
L
--------------
E
F
I
F
F
N
E
G
C
Q
--
A
E
S
I
C
K
E
F
Y
I
S
S
S
S
L
Y
R
I
I
S
Q
I
N
K
V
I
K
R
Q
F
Q
--
F
E
V
S
L
--------
T
P
V
Q
I
I
--
G
N
E
R
D
I
R
Y
F
F
A
Q
Y
F
-
S
E
K
Y
Y
F
L
E
----------
W
P
F
E
N
--
F
S
S
E
P
L
S
Q
-------
L
L
E
L
V
Y
K
E
T
--------------
S
F
P
M
N
L
S
T
H
R
--------------
M
L
K
L
L
L
V
T
N
--
L
Y
R
I
K
F
----
G
H
F
------
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
49.24
17%
-10
- C6 -
-
4R6I
1
ATXA_BACAN
A:
[26-217]
-----------------------------------------------------------------
E
-
Q
N
R
W
F
T
I
K
E
L
S
D
Y
L
Q
V
A
D
K
T
V
R
K
Y
L
K
L
L
E
D
E
I
P
P
S
-
W
N
L
L
V
Q
K
G
K
G
I
Y
L
K
K
P
-----
L
N
E
S
L
---
S
F
V
E
S
K
------------------------
I
L
R
K
S
L
N
L
Q
I
C
--------------
E
E
L
V
F
K
K
-
N
S
--
M
Q
S
L
A
Q
K
L
H
L
Q
V
G
A
L
Y
P
I
I
N
Q
I
----
N
Y
D
I
Q
-
S
S
H
L
N
I
--------
K
K
K
P
L
E
I
S
G
R
E
Q
D
V
R
V
F
-
M
L
R
L
-
Y
C
N
I
P
N
D
Y
----------
W
P
F
P
Y
--
I
N
K
Q
N
I
T
D
-------
L
I
N
K
M
E
K
I
L
--------------
N
V
Q
M
Y
T
Y
S
K
H
--------------
K
L
C
V
L
F
A
I
T
--
I
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
47.90
14%
-86
- C6 -
-
1TVM
-
PTKB_ECOL6
A:
[19-112]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
R
K
I
I
-------------
V
A
C
-
G
G
A
V
A
T
S
-------
T
M
A
A
--
E
E
----
I
K
E
L
C
--
Q
S
H
--
N
--
I
--
P
V
E
L
I
Q
C
R
V
N
E
IE------
T
--
Y
M
D
G
V
H
L
I
C
T
T
A
R
V
D
R
S
F
--------------
G
D
I
P
L
V
H
G
M
P
F
V
-
S
G
V
G
--
I
E
A
L
Q
N
K
I
L
T
I
L
Q
---------------------------------
48
Fugue
46.70
17%
21
- C4 -
-
5F30
-
?
A:
[82-548]
--------KY
V
K
V
Q
D
F
Y
D
Q
L
G
K
Y
V
L
V
A
P
G
K
F
S
G
--
T
V
A
A
T
D
L
---
S
T
G
W
T
M
A
W
L
A
A
W
N
------
Y
G
-
D
T
C
P
I
M
H
H
M
A
A
F
P
S
P
D
P
Y
K
E
F
E
F
V
V
----
N
T
Q
G
G
K
-
N
L
F
I
Y
G
V
--
P
V
T
V
E
D
P
G
E
G
M
K
I
Y
R
I
K
Y
DG
T
R
M
N
L
Q
-------------------
R
D
A
A
E
V
S
G
L
G
L
G
V
H
V
T
I
T
PEAD
G
Y
A
V
G
D
GQ
K
D
I
C
A
E
F
D
R
E
TD
M
V
R
Y
A
W
A
F
D
W
D
P
N
V
K
D
L
K
-
R
A
W
LD
G
G
T
M
T
I
K
-
R
L
K
P
T
L
--------
P
G
G
R
Y
D
L
Q
G
S
K
G
------
N
K
I
D
-
W
E
L
V
P
G
G
E
----------
L
A
I
E
D
GK
V
S
G
D
R
P
L
H
-------
S
V
A
N
D
A
L
V
F
--------------
D
P
R
------------------------------------------
G
K
W
------
A
---
V
A
S
M
---
R
L
P
G
V
C
V
----------
V
---
F
D
R
E
N
Q
V
P
V
A
V
L
A
G
P
KGT
P
--
S
Q
F
Q
L
V
K
V
D
D
D
T
-
W
T
V
D
I
------------------------
P
----------------
E
V
---
I
S
A
G
H
Q
---------------------------
A
G
F
S
P
D
G
--
Q
----------------------------------
S
F
L
F
M
N
S
L
R
Q
N
N
I
M
V
W
D
S
S
N
-----
H
---
D
D
P
T
T
W
E
K
K
A
V
V
E
S
P
D
W
----------------------
R
G
A
-
Y
-
P
N
TF
H
M
V
F
T
P
D
A
----
K
--
K
I
Y
V
T
M
----
W
W
P
-----
S
P
T
P
N
G
I
A
V
I
-------------
D
A
V
-
N
W
E
V
L
K
E
-------
V
D
L
G
--
P
D
----
M
H
T
L
A
I
T
Y
D
G
-
K
F
--
V
--
V
----
G
T
L
S
-
G
--------
Y
--
Q
N
T
A
S
A
I
V
V
M
E
T
E
T
-------------------
D
E
V
L
G
F
L
P
S
P
M
-
G
H
H
D
--
N
V
I
V
P
R
T
L
E
D
L
R
I
S
R
S
T
T
T
---------------------------
36
HHSearch
40.67
10%
-85
- C6 -
-
4MGE
-
?
B:
[1-102]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
I
L
-------------
L
C
C
-
S
A
G
M
S
T
S
-------
L
L
V
T
---
K
----
M
E
A
A
A
--
K
A
R
G
L
E
GK
I
--
W
----
A
V
S
G
-
D
AVK-----
T
--
N
I
D
Q
A
D
V
L
L
L
G
P
Q
V
R
Y
M
L
SSMKTLAD
E
-----
R
N
V
G
I
D
V
I
N
P
M
H
Y
G
M
M
N
--
G
E
A
V
L
D
H
A
L
T
L
K
K
G
E
-------------------------------
35
HHSearch
40.15
10%
-72
- C6 -
-
4MGE
1
?
A:
[1-102]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
I
L
-------------
L
C
C
-
S
A
G
M
S
T
S
-------
L
L
V
T
---
K
----
M
E
A
A
A
--
K
A
R
G
L
E
G
K
I
--
W
----
A
V
S
G
-
D
AVK-----
T
--
N
I
D
Q
A
D
V
L
L
L
G
P
Q
V
R
Y
M
L
S
S
M
K
T
L
A
D
E
-----
R
N
V
G
I
D
V
I
N
P
M
H
Y
G
M
M
N
--
G
E
A
V
L
D
H
A
L
T
L
K
K
G
E
-------------------------------
46
Fugue
39.75
13%
13
* C5 *
-
5LRT
5
DOP_ACIC1
A:
[1-500]
----------
M
H
R
V
M
G
I
E
T
E
------------------------------
Y
G
I
S
V
P
H
Q
------
P
N
-
A
N
A
M
A
A
S
S
Q
V
V
N
A
Y
A
P
I
G
A
P
A
Q
G
L
A
----
N
V
I
L
T
N
G
A
R
L
Y
V
D
H
A
H
P
E
Y
S
---------------------------------------------
T
P
E
V
T
N
P
R
D
A
V
L
--------------
W
D
K
A
G
E
R
I
M
A
--
E
A
A
R
R
A
A
D
L
P
M
G
W
T
I
Q
L
Y
K
N
N
T
----
D
N
K
G
A
-
S
Y
G
C
H
E
--------
N
Y
L
M
N
R
S
T
P
F
A
D
I
V
R
H
L
I
P
F
F
V
T
R
Q
V
F
C
G
-------------------
A
G
R
V
G
I
G
A
-------
D
G
R
G
E
G
F
Q
L
--------------
S
Q
R
A
D
F
F
E
V
E
--------------
V
G
-----------
L
E
T
T
----
L
K
R
------
P
---
I
I
N
T
R
D
E
P
H
-
A
D
P
E
----------
K
---
Y
R
R
L
H
V
I
I
G
D
A
N
------
M
--
S
E
I
A
T
Y
L
K
L
G
T
T
-
A
L
V
L
A
M
I
--
E
D
G
F
--------------
L
S
Q
-----------------------
D
F
S
V
---------------------------
E
S
P
V
G
A
L
--
R
----
A
V
S
H
D
P
------
T
L
R
Y
Q
L
R
L
H
D
G
----
R
R
L
T
A
V
Q
L
Q
M
E
Y
L
E
Q
A
R
K
Y
V
E
D
R
F
G
T
D
V
D
---
D
M
T
R
D
V
L
D
R
W
E
T
T
L
V
R
L
A
D
DPMQLSRDL
D
W
V
A
K
L
S
I
L
E
G
Y
R
Q
-
R
-
E
N
---
L
P
W
S
A
H
K
L
--
Q
L
V
D
L
Q
Y
H
D
V
----
R
P
D
R
G
L
-
Y
N
R
L
V
A
R
G
R
M
N
-------------
L
L
V
-
D
E
A
A
V
R
T
-------
A
M
H
E
PP
N
D
----
T
R
A
Y
F
--
R
G
R
-
C
L
--
A
--
K
----
F
G
A
E
-
I
--------
A
--
A
A
S
W
D
S
V
I
F
D
L
P
G
R
D
S
L
Q
--------
R
-----
V
P
T
L
E
P
L
R
G
T
R
A
-
H
V
G
D
--
L
L
D
R
C
R
S
A
T
E
L
V
A
A
L
T
------------------------------
42
HHSearch
39.36
13%
-84
- C6 -
-
1IIB
-
PTQB_ECOLI
A:
[3-100]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
H
I
Y
-------------
L
F
S
-
S
A
G
M
S
-
T
-------
S
L
L
V
--
S
K
----
M
R
A
Q
A
--
E
K
Y
E
V
P
--
V
I
I
E
----
A
F
P
E
-
T
L
A
G
-----
E
--
K
G
Q
N
A
D
V
V
L
L
G
P
Q
I
A
Y
M
L
P
-------
E
I
Q
R
L
L
P
N
K
P
V
E
V
I
D
S
L
L
Y
G
K
V
D
--
G
L
G
V
L
K
A
A
V
A
A
I
----------------------------------
41
HHSearch
38.19
9%
-246
- C6 -
-
1WI9
-
A:
[101-145]
----------------------------------------------
G
S
S
G
F
L
T
E
F
I
N
Y
------
I
K
-
K
S
K
V
V
L
L
E
D
L
A
F
Q
M
G
L
R
T
Q
D
A
I
N
R
I
----
Q
D
L
L
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
37.94
11%
-55
- C6 -
-
1H99
-
LICT_BACSU
A:
[68-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
E
C
M
E
V
S
E
E
-------
I
I
S
Y
A
K
L
Q
L
--------------
G
K
K
L
N
D
S
I
Y
V
--------------
S
L
T
D
H
I
N
F
A
--
I
Q
R
N
Q
K
----
G
L
D
------
I
---
K
N
A
L
L
W
E
T
K
R
L
Y
K
D
----------
E
---
F
A
I
G
K
E
A
L
V
M
V
K
------
N
K
T
G
V
S
L
P
E
D
E
A
G
F
I
-
A
L
H
I
V
N
A
--
E
L
N
E
--------------
E
M
-------------------
P
------------------------------------
N
I
I
N
I
T
--
K
----
V
M
E
E
---------
I
L
S
I
V
K
Y
H
F
K
I
E
F
N
E
E
S
--
L
H
Y
-
Y
R
F
V
T
D
L
K
F
F
A
Q
R
L
F
N
G
T
H
M
----
E
D
D
F
L
L
D
T
V
K
E
K
Y
H
R
A
Y
----------
E
C
T
K
--
K
I
Q
T
Y
I
E
R
E
Y
-
E
H
--
K
L
T
S
D
E
L
L
Y
--
L
T
--
I
D
I
E
R
V
----
V
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
35.48
16%
-21
- C6 -
-
2FEW
-
?
B:
[376-471]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
R
K
I
I
-------------
V
A
S
-
D
A
G
M
G
S
S
-------
A
M
G
A
--
G
V
----
L
R
K
K
I
--
Q
D
--
A
G
--
L
--
S
QIS-
V
T
N
S
-
A
--------
I
NN
L
P
P
D
V
D
L
V
I
T
H
R
D
L
T
E
R
A
--------
M
RQV--
P
Q
A
Q
H
I
S
L
T
N
F
L
-
D
S
G
L
--
Y
T
S
L
T
E
R
L
V
A
A
Q
R
H
--------------------------------
12
PsiBlast_PDB
35.33
29%
-156
- C6 -
-
4BW9
3
A:
[75-148]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
E
N
Y
L
G
K
L
E
R
E
I
T
R
F
F
V
D
R
G
F
-
L
E
I
K
S
P
I
L
----------
I
P
L
E
Y
--
I
E
R
M
G
I
D
N
-------
D
T
E
L
S
K
Q
I
F
--------------
R
V
D
K
N
F
C
L
R
P
--------------
M
L
A
P
N
L
G
N
---
Y
L
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
35.07
10%
-31
- C6 -
-
5GQS
-
?
A:
[2-90]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
V
L
-------------
V
A
C
-
G
A
G
I
A
T
S
-------
T
V
V
N
--
N
A
----
I
E
E
M
A
--
K
E
H
N
I
K
V
D
I
--
K
----
Q
I
K
I
T
E
VG------
P
--
Y
E
D
T
A
D
L
L
V
T
T
A
M
T
K
K
E
---------------
Y
K
F
P
V
I
N
A
R
N
F
L
-
T
G
I
G
--
I
E
E
T
K
Q
Q
I
L
T
E
L
----------------------------------