@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TYE1: (2017-12-14 )
MKQLTVDEAAKEILAYQQITFLTGAGVSTPSGVPDYRSLSGIYHGMEQPEYLLSHQAMVNEPDKFYQFVKKIYHPEAKPNIIHLEIAHLAKEKNVWVVSQNIDGLHAKAKSPQLVNFHGSLYQCHCRKCQQTVDWKEYLHSDKHQACGGQIRPDIVLYGEGFQDGVMEQAAYAVSQAELIVIVGTSFQVHPFCDLVQFRQPSAKILVINQTPVYLAEPYTFIQEDGAVVFKKIQELGADYD
Atome Classification :
(26 SA)
--------------------------------------------------------------------------------------------------------------------.........10...--.--.--...20-........30........-40......-----.-----.----50........60........70..--..--....80..--......90.-....--...100.......--110-.--.......120......--.130-..---.--....------.------140---..--...---------------------------------..-150.......160.......170.......180.......190..--.....200........--210....--------------------.-----.-.220.......230.......240-------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------MKQL
T
V
D
E
A
A
K
E
I
L
--
A
--
Y
--
Q
Q
I
T
F
-
L
TGAGVSTPSGVP
D
Y
R
S
L
-
S
G
I
YHGME-----Q-----
P
----
E
Y
L
L
S
H
Q
A
MVNE
P
D
K
F
Y
Q
F
V
K
K
I
Y--HP--EAKP
N
I
I
H
--
L
E
I
A
H
LAKE-K
N
V
W
--
V
V
SQNIDGLHAKA--KS--
P
--
Q
L
V
NFHG
S
L
Y
Q
C
H
C
R
K
--
C
Q
Q--TV---
D
--
W
K
E
Y
------
L
------
H
SD---KH--QAC---------------------------------GG-QIRP
D
I
V
L
YGEGFQD
G
V
M
E
Q
A
A
Y
AVSQ
A
E
L
I
V
I
VGTSFQVH
P
F
C
D
--
L
V
Q
FRQP-S
A
K
I
L
V
I
N--QT
P
V
Y
L
A--------------------E-----P-
Y
T
F
I
QED
G
A
V
V
F
K
K
I
Q
E
LGADYD--------------------------
72
HHSearch
86.33
27%
-39
- C3 -
-
2H59
1
NPD_THEMA
A:
[2-243]
------------------------------------------------------------------------------------------------------------------------
K
M
K
E
F
L
D
L
L
N
--
E
--
S
--
R
L
T
V
T
-
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
G
P
-
N
G
I
Y
K
K
Y
S
----------------
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
FP
M
L
--
Q
A
K
P
N
L
A
H
--
V
L
L
A
K
L
E
E
K
G
L
I
E
A
--
V
I
T
Q
N
I
D
R
L
H
Q
R
A
--
G
S
--
K
--
K
V
I
E
L
A
G
N
V
E
E
Y
Y
C
V
R
--
C
E
K
--
K
Y
---
T
--
V
E
D
V
I
K
K
L
E
S
S
------
D
V
P
---
L
C
--
D
D
C
---------------------------------
N
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
--
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
--
L
G
E
T
P
F
D
--------------------
D
I----
A
-
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
M
E
E
G
------------------------------
83
HHSearch
84.13
26%
-38
- C3 -
-
2HJH
2
SIR2_YEAST
B:
[33-316]
----------------------------------------------------------------------------------------------------------------------
F
F
T
I
D
H
F
I
Q
K
L
H
--
T
--
A
--
R
K
I
L
V
-
L
T
G
A
G
V
S
T
S
L
G
I
P
D
F
R
S
S
-
E
G
F
Y
S
K
I
K
H
L
GLD
D
-----
P
----
Q
D
V
F
N
Y
N
I
F
M
H
D
P
S
V
F
Y
N
I
A
N
M
V
L
--
P
P
--
E
K
I
Y
S
P
L
H
--
S
F
I
K
M
L
Q
M
K
G
K
L
L
R
--
N
Y
T
Q
N
I
D
N
L
E
S
Y
A
--
G
I
ST
D
--
K
L
V
Q
C
H
G
S
F
A
T
A
T
C
V
T
--
C
H
W
--
N
L
---
P
--
G
E
R
I
------
F
N
K
I
R
N
L
E
L
P
---
L
C
--
P
Y
C
Y
K
K
R
R
E
Y
FSMSERPPYILNS-------------
Y
G
-
V
L
K
P
D
I
T
F
F
G
E
A
L
P
N
K
F
H
K
S
I
R
E
D
I
L
E
C
D
L
L
I
C
I
G
T
S
L
K
V
A
P
V
S
E
--
I
V
N
M
V
P
S
-
H
V
P
Q
V
L
I
N
--
R
D
P
V
K
H
A
--------------------
E
-----
F
-
D
L
S
L
L
G
Y
C
D
D
I
A
A
M
V
A
Q
K
C
------------------------------
79
HHSearch
83.80
28%
-38
- C3 -
-
1M2K
1
NPD1_ARCFU
A:
[3-242]
--------------------------------------------------------------------------------------------------------------------------
E
K
L
L
K
T
I
A
--
E
--
S
--
K
Y
L
V
A
-
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
R
-----------
P
----
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
F
--
N
A
Q
P
N
K
A
H
--
Q
A
F
A
E
L
E
R
L
G
V
L
K
C
--
L
I
T
Q
N
V
D
D
L
H
E
R
A
--
G
S
--
R
--
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
--
C
N
N
--
S
F
---
E
--
V
E
S
A
P
K
I
---
P
------
P
L
P
---
K
C
--
D
K
C
---------------------------------
G
S
-
L
L
R
P
G
V
V
W
A
G
E
M
L
P
P
D
V
L
D
R
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
--
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
--
P
D
E
T
P
L
T
--------------------
P
I----
A
-
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
----------------------------
81
HHSearch
81.88
30%
-12
- C3 -
-
4BN4
2
SIR3_HUMAN
A:
[6-262]
---------------------------------------------------------------------------------------------------------------------
G
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
QYDLP
Y
-----
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
--
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
PA
S
--
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
---
P
--
G
E
D
I
R
A
D
V
M
A
D
------
R
V
P
---
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
D
L
V
G
P
L
--------------------
A
WHPRS
R
-
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
------------------------------
80
HHSearch
81.81
28%
-35
- C3 -
-
1M2N
1
NPD1_ARCFU
A:
[2-242]
-------------------------------------------------------------------------------------------------------------------------
D
E
K
L
L
K
T
I
A
--
E
--
S
--
K
Y
L
V
A
-
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
N
R
Y
R
-----------
P
----
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
A
W
R
M
E
K
V
F
--
N
A
Q
P
N
K
A
H
--
Q
A
F
A
E
L
E
R
L
G
V
L
K
C
--
L
I
T
Q
N
V
D
G
L
H
E
R
A
--
G
S
--
R
--
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
--
C
N
N
--
S
F
---
E
--
V
E
S
A
PKI---
P
------
P
L
P
---
K
C
--
D
K
C
---------------------------------
G
S
-
L
L
R
P
G
V
V
W
A
G
E
M
L
P
P
D
V
L
D
A
A
M
R
E
V
E
R
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
--
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
--
P
D
E
T
P
L
T
--------------------
P
I----
A
-
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
----------------------------
94
Fugue
81.34
25%
-31
- C3 -
-
4IAO
1
SIR2_YEAST
A:
[29-485]
SMSNDVLKPETPKGPIIISSNGIFYGPSFT
K
R
E
S
L
N
A
R
M
F
L
K
Y
YG
A
H
K
F
L
D
T
Y
L
PEDLNS
L
Y
I
Y
Y
L
I
K
L
L
GFEVKD
Q
A
L
I
G
T
I
N
S
IVDPLA
K
K
Q
T
V
R
L
I
K
D
L
Q
R
A
I
N
K
V
L
C
T
R
L
R
L
S
N
F
F
T
I
D
H
F
I
Q
K
L
H
--
T
--
A
--
R
K
I
L
V
-
L
T
G
A
G
V
S
T
S
L
G
I
P
D
F
R
S
S
-
E
G
F
Y
S
K
I
K
-----
H
L
GLDD
P
----
Q
D
V
F
N
Y
N
I
F
M
H
D
P
S
V
F
Y
N
I
A
N
M
V
L
--
P
P
--
E
K
I
Y
S
P
L
H
--
S
F
I
K
M
L
Q
M
K
G
K
L
L
R
--
N
Y
T
Q
N
I
D
N
L
E
S
Y
A
GI
S
T
--
D
--
K
L
V
Q
C
H
G
S
F
A
T
A
T
C
V
T
--
C
H
W
--
N
L
---
P
--
G
E
R
I
------
F
------
N
K
I
---
R
N
--
L
E
L
PLCPYC
Y
K
K
R
R
E
Y
F
PEGYNNKSMSERPPYILNS
Y
G
-
V
L
K
P
D
I
T
F
F
G
E
A
L
P
N
K
F
H
K
S
I
R
E
D
I
L
E
C
D
L
L
I
C
I
G
T
S
L
K
V
A
P
V
S
E
--
I
V
N
M
V
P
S
-
H
V
P
Q
V
L
I
N
--
R
D
P
V
K
H
A
--------------------
E
-----
F
D
L
S
L
L
G
Y
C
D
D
I
A
A
M
V
A
Q
K
C
G
W
T
I
P
HKKWNDLKN
K
N
F
K
S
Q
E
KDKG
V
Y
V
V
T
S
71
HHSearch
81.21
28%
-37
- C3 -
-
1YC5
1
NPD_THEMA
A:
[2-243]
------------------------------------------------------------------------------------------------------------------------
K
M
K
E
F
L
D
L
L
N
--
E
--
S
--
R
L
T
V
T
-
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
----------------------------
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
FP
M
L
--
Q
A
K
P
N
L
A
H
--
V
L
L
A
K
L
E
E
K
G
L
I
E
A
--
V
I
T
Q
N
I
D
R
L
H
Q
R
A
--
G
S
--
K
--
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
--
C
E
K
--
K
Y
---
T
--
V
E
D
V
I
K
K
L
E
S
S
------
D
V
P
---
L
C
--
D
D
C
---------------------------------
N
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
--
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
--
L
G
E
T
P
F
D
--------------------
D
I----
A
-
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
M
E
E
G
------------------------------
84
HHSearch
79.62
26%
-22
- C3 -
-
2HJH
2
SIR2_YEAST
A:
[33-316]
----------------------------------------------------------------------------------------------------------------------
F
F
T
I
D
H
F
I
Q
K
L
H
--
T
--
A
--
R
K
I
L
V
-
L
T
G
A
G
V
S
T
S
L
G
I
P
D
F
R
S
S
-
E
G
F
Y
S
K
I
K
HLGLD
D
-----
P
----
Q
D
V
F
N
Y
N
I
F
M
H
D
P
S
V
F
Y
N
I
A
N
M
V
L
--
P
P
--
E
K
I
Y
S
P
L
H
--
S
F
I
K
M
L
Q
M
K
G
K
L
L
R
--
N
Y
T
Q
N
I
D
N
L
E
S
Y
A
--
G
I
ST
D
--
K
L
V
Q
C
H
G
S
F
A
T
A
T
C
V
T
--
C
H
W
--
N
L
---
P
--
G
E
R
I
------
F
N
K
I
R
N
L
E
L
P
---
L
C
--
P
Y
C
Y
K
K
R
R
E
Y
F
PERPPYILNS---------------
Y
G
-
V
L
K
P
D
I
T
F
F
G
E
A
L
P
N
K
F
H
K
S
I
R
E
D
I
L
E
C
D
L
L
I
C
I
G
T
S
L
K
V
A
P
V
S
E
--
I
V
N
M
V
P
S
-
H
V
P
Q
V
L
I
N
--
R
D
P
V
K
H
A
--------------------
E
-----
F
-
D
L
S
L
L
G
Y
C
D
D
I
A
A
M
V
A
Q
K
C
------------------------------
85
HHSearch
78.72
30%
-14
- C3 -
-
4FVT
2
SIR3_HUMAN
A:
[2-257]
-----------------------------------------------------------------------------------------------------------------------
L
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
QYDLP
Y
-----
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
--
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
PA
S
--
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
---
P
--
G
E
D
I
R
A
D
V
M
A
D
------
R
V
P
---
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
D
L
V
G
P
L
AWHP----------------
R
S----
R
-
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-----------------------------
35
PsiBlast_CBE
77.24
31%
-6
- C3 -
-
4BVB
2
SIR3_HUMAN
A:
[7-230]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
--
R
AC
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
-----
Q
YDLPY
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
-
D
K
G
-
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
--
P
AS
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
PGE
D
--
I
R
A
D
------
V
------
M
A
D
RVP
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
-----------------------------------------------------------------------------------
34
PsiBlast_CBE
76.50
31%
-9
- C3 -
-
4BVE
1
SIR3_HUMAN
A:
[7-230]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
--
R
AC
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
-----
Q
YDLPY
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
-
D
K
G
-
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
--
P
AS
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
P
GE
D
--
I
R
A
D
------
V
------
M
A
D
RVP
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
-----------------------------------------------------------------------------------
63
PsiBlast_CBE
76.48
31%
-13
- C3 -
-
5D7N
3
SIR3_HUMAN
F:
[8-231]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
--
R
AC
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
-----
Q
YDLPY
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
YF
L
R
L
L
H
-
D
K
G
-
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
--
P
AS
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
PGE
D
--
I
R
A
D
------
V
------
M
A
D
RVP
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
-----------------------------------------------------------------------------------
74
HHSearch
76.13
28%
-28
- C3 -
-
1S7G
-
NPD2_ARCFU
A:
[2-248]
----------------------------------------------------------------------------------------------------------------------
E
D
E
I
R
K
A
A
E
I
L
A
--
K
--
S
--
K
H
A
V
V
-
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
-
D
G
L
W
R
K
Y
D
-----------
P
----
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
M
E
M
K
D-
K
L
--
F
A
E
P
N
P
A
H
--
Y
A
I
A
E
L
E
R
M
G
I
V
K
A
--
V
I
T
Q
N
I
D
M
L
H
Q
R
A
--
G
S
--
R
--
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
--
C
H
E
--
T
Y
---
D
--
W
S
E
F
V
E
D
F
N
K
G
------
E
I
P
---
R
C
--
R
K
C
---------------------------------
G
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
R
T
L
F
E
A
I
E
E
A
K
H
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
E
--
L
P
Y
I
A
K
K
A
G
A
K
M
I
I
V
N
--
A
E
P
T
M
A
D
--------------------
P
I----
F
-
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
----------------------------
32
PsiBlast_CBE
76.10
31%
-5
- C3 -
-
4BVG
11
SIR3_HUMAN
A:
[7-230]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
--
R
AC
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
-----
Q
YDLPY
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
-
D
K
G
-
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
--
P
AS
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
P
GE
D
--
I
R
A
D
------
V
------
M
A
D
RVP
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
-----------------------------------------------------------------------------------
65
PsiBlast_CBE
76.05
31%
-10
- C3 -
-
5D7N
3
SIR3_HUMAN
D:
[8-231]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
--
R
AC
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
-----
Q
YDLPY
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
YF
L
R
L
L
H
-
D
K
G
-
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
--
P
AS
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
PGE
D
--
I
R
A
D
------
V
------
M
A
D
RVP
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
-----------------------------------------------------------------------------------
78
HHSearch
76.03
28%
-3
- C3 -
-
5MAR
15
SIR2_HUMAN
A:
[7-282]
---------------------------------------------------------------------------------------------------------------------
D
E
L
T
L
E
G
V
A
R
Y
M
Q
SE
R
--
C
--
R
R
V
I
C
-
L
V
G
A
G
I
S
T
S
A
G
I
P
D
F
R
S
P
S
T
G
L
Y
D
N
L
E
KYHLP
Y
-----
P
----
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
L
Y
--
P
G
--
Q
F
K
P
T
I
C
H
--
Y
F
M
R
L
L
K
D
K
G
L
L
L
R
--
C
Y
T
Q
N
I
D
T
L
E
R
I
A
--
G
L
EQ
E
--
D
L
V
E
A
H
G
T
F
Y
T
S
H
C
V
S
AS
C
R
H
--
E
Y
---
P
--
L
S
W
M
K
E
K
I
F
S
E
------
V
T
P
---
K
C
--
E
D
C
---------------------------------
Q
S
-
L
V
K
P
D
I
V
F
F
G
E
S
L
P
A
R
F
F
S
C
M
Q
S
D
F
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
--
L
I
S
K
A
P
L
-
S
T
P
R
L
L
I
N
--
K
E
K
A
G
Q
S
DPFLGMIMGLGGGMDFDSKK
A
Y----
R
-
D
V
A
W
L
G
E
C
D
Q
G
C
L
A
L
A
E
L
L
------------------------------
31
PsiBlast_CBE
75.99
31%
-12
- C3 -
-
4BVH
2
SIR3_HUMAN
A:
[7-230]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
--
R
AC
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
-----
Q
YDLPY
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
-
D
K
G
-
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
--
P
AS
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
P
G
E
D
--
I
R
A
D
------
V
------
M
A
D
RVP
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
-----------------------------------------------------------------------------------
37
PsiBlast_CBE
75.82
31%
-7
- C3 -
-
4BN4
2
SIR3_HUMAN
A:
[7-230]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
--
R
AC
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
-----
Q
YDLPY
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
-
D
K
G
-
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
--
P
AS
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
P
GE
D
--
I
R
A
D
------
V
------
M
A
D
RVP
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
-----------------------------------------------------------------------------------
68
PsiBlast_CBE
75.76
31%
-12
- C3 -
-
5D7N
2
SIR3_HUMAN
A:
[8-231]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
--
R
AC
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
-----
Q
YDLPY
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
-
D
K
G
-
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
--
P
AS
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
P
GE
D
--
I
R
A
D
------
V
------
M
A
D
RVP
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
-----------------------------------------------------------------------------------
30
PsiBlast_CBE
75.54
31%
-6
- C3 -
-
4BVH
5
SIR3_HUMAN
B:
[7-230]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
--
R
AC
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
-----
Q
YDLPY
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
-
D
K
G
-
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
--
P
AS
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
PG
E
D
--
I
R
A
D
------
V
------
M
A
D
RVP
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
-----------------------------------------------------------------------------------
41
PsiBlast_CBE
74.53
31%
-9
- C3 -
-
4JSR
1
SIR3_HUMAN
A:
[8-231]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
--
R
AC
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
-----
Q
YDLPY
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
-
D
K
G
-
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
--
P
AS
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
P
GE
D
--
I
R
A
D
------
V
------
M
A
D
RVP
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
-----------------------------------------------------------------------------------
40
PsiBlast_CBE
72.74
31%
-8
- C3 -
-
4JT8
1
SIR3_HUMAN
A:
[8-231]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
--
R
AC
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
-----
Q
YDLPY
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
-
D
K
G
-
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
--
P
AS
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
P
GE
D
--
I
R
A
D
------
V
------
M
A
D
RVP
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
-----------------------------------------------------------------------------------
13
PsiBlast_PDB
72.25
34%
-12
- C3 -
-
4BV2
2
NPD_THEMA
A:
[8-219]
-------------------------------------------------------------------------------------------------------------------------------
D
L
L
--
N
--
E
--
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
----------
Y
S
-----
Q
-----
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
--
F
P
ML
Q
A
K
P
N
L
A
H
--
V
L
L
A
K
L
-
E
E
-
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
--
G
S
--
K
--
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
--
C
E
K
K
Y
T
V
---
E
D
V
I
K
K
L
------
E
------
S
S
D
---
V
P
L
C
D
D
C
---------------------------------
N
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
--
G
G
K
L
V
I
V
N
LG
E
T
P
---------------------------------------------------------------------------------
39
PsiBlast_CBE
72.14
31%
-11
- C3 -
-
4JT9
3
SIR3_HUMAN
A:
[8-231]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
--
A
--
R
AC
Q
R
V
V
V
-
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
-----
Q
YDLPY
P
----
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
--
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
-
D
K
G
-
L
L
L
R
--
L
Y
T
Q
N
I
D
G
L
E
R
V
S
--
G
I
--
P
AS
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
--
P
F
P
GE
D
--
I
R
A
D
------
V
------
M
A
D
RVP
R
C
--
P
V
C
---------------------------------
T
G
-
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
V
-
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
--
L
T
E
A
V
R
S
-
S
V
P
R
L
L
I
N
--
R
-----------------------------------------------------------------------------------
3
PsiBlast_PDB
70.21
34%
-9
- C3 -
-
2H4J
2
NPD_THEMA
A:
[8-219]
-------------------------------------------------------------------------------------------------------------------------------
D
L
L
--
N
--
E
--
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-----------
S
-----
Q
-----
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
--
F
P
M
L
Q
A
K
P
N
L
A
H
--
V
L
L
A
K
L
-
E
E
-
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
--
G
S
--
K
--
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
--
C
E
K
K
Y
T
V
---
E
D
V
I
K
K
L
------
E
------
S
S
D
---
V
P
L
C
D
D
C
---------------------------------
N
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
--
G
G
K
L
V
I
V
N
LG
E
T
P
---------------------------------------------------------------------------------
1
PsiBlast_PDB
67.79
34%
-12
- C3 -
-
1YC5
1
NPD_THEMA
A:
[8-219]
-------------------------------------------------------------------------------------------------------------------------------
D
L
L
--
N
--
E
--
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-----------------
Q
-----
N
VFD
I
D
F
F
Y
S
H
------
P
E
E
F
Y
R
F
A
K
E
G
I
--
F
P
ML
Q
A
K
P
N
L
A
H
--
V
L
L
A
K
L
-
E
E
-
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
--
G
S
--
K
--
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
--
C
E
K
K
Y
T
V
---
E
D
V
I
K
K
L
------
E
------
S
S
D
---
V
P
L
C
D
D
C
---------------------------------
N
S
-
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
--
G
G
K
L
V
I
V
N
LG
E
T
P
---------------------------------------------------------------------------------