@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TYH2: (2017-12-14 )
MRRFAINGYGEAQDVFEEIDAHPREVGSGHVRVEIKAFSVNPYDVALRLGEMKEIRTLKFPYVPGNDGAGIVTEIGSDVTTVHVGDRVAVHAVGGTYGEEVVLPSAKVAKIPDKMSWEEAAGMVTPGITAYNLINHLTEIQPTDTVMILGASGAVGSSLIQLLHEKGIRILTSASSKNEEKVKKLGASAFAAYDKTNPGLQFADQADLVIDATKGSIKGETGIQIMKPGGRYVALNDLPDLDLRQKKEGFYESFVPRKEYLDAEAFAGIIKAYQKGAFHVFISMNLSASLKHVIQAHQLVEGHPPAGKIILSFEK
Atome Classification :
(20 SA)
.......--..10...-.....-20...-.....30........40........50----------------....-------------.-------...60........70........80---.........90---------------------------.---.-----------------------------.---------------------------.------------------------.....100.......110.......120.........130....--.--.--.---140----........150.......160.......170...-.-...-180.......190.....-----------------.----------------------.-------200------------------------.------------------.----.-----..---------....-----210.......220--........230..----------....--------.240--.---...---.----.---..---250---.-....--.--------.260.......270.......280.......290.......300-...-....310...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
R
R
F
A
IN--GYG
E
A
Q
D
-
V
F
E
E
I-DAH
P
R
-EVGS
G
H
V
R
V
E
I
K
A
F
SVN
P
Y
D
V
A
L
RLG
E
----------------
M
K
E
I
-------------
R
-------
T
L
KFPYVPGNDGA
G
I
V
T
EIGS
D
V
T
----
T
V
H
VG
D
R
V
A
V
----------------------------
H
---
A
-----------------------------V---------------------------G------------------------GTYGEEVVLPS
A
K
V
AKIPDKM
S
W
E
E
A--AGMVTP
G
I
T
A
Y
N
L
I
N
H
--
L
--T--E---IQ-----PT
D
T
V
M
I
L
GASGA
V
G
S
S
L
I
Q
L
L
H
EKG
I
R
I
L
TSAS-S-K
N
E
-
E
K
V
K
K
L
G
A
S
A
FAAYDKTN-----------------P----------------------G-------L--------------------------Q------------------F----A-----DQ---------A
D
L
V
-----
I
D
ATKGSIKGET---G
I
Q
I
MKPG
G
R
Y
V
A----------LNDL--------PD
L
---
D
---
L
R
Q
---
K
----
K
---
E
G
---
F
Y
E
---S-FV
P
R
--
K
--------
E
YL
D
A
E
A
F
A
G
I
I
K
A
Y
QKG
A
F
H
V
F
I
SMN
L
S
A
S
L
K
H
V
I
Q
A
H
Q
LVEG-HPP-A
G
K
I
I
L
SFEK
41
HHSearch
77.50
25%
23
- C1 -
-
4RVS
-
?
A:
[2-328]
M
H
A
I
E
V
T
--
E
T
G
G
P
-
G
-
V
L
R
H
V
-
D
Q
-
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
Q
----------------
Y
P
------------------------
R
E
L
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
T
AADT
A
I
S
V
G
D
R
V
V
S
----------------------------
A
---
S
-----------------------------
A
---------------------------
N
------------------------
G
A
Y
A
E
F
C
T
A
P
A
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
--
A
S
A
L
L
K
G
L
T
A
H
Y
L
L
K
S
--
V
--
Y
--
P
---
V
K
-----
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
R
V
I
T
T
V
S
-
T
A
E
K
A
-
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
---------------
F
----------------------
A
-------
G
--------------------------
R
------------------
V
----
R
E
L
T
GG
T
G
---------
V
Q
A
V
-----
Y
D
G
V
G
A
T
T
-
F
D
A
---
S
L
A
S
L
A
V
R
G
T
L
A
L
----------
F
G
A
A
--------
S
G
P
V
P
-
P
---
V
D
P
---
Q
----
R
L
N
A
A
G
S
V
Y
L
T
R
P
--
S
L
F
H
F
T
R-
T
--------
G
E
E
F
S
W
R
A
A
E
L
F
D
A
I
G
N
E
A
I
T
V
A
V
G
G
R
Y
--
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
K
-
T
-
V
G
S
V
V
L
L
---
48
HHSearch
74.33
25%
9
- C1 -
-
4RVU
1
?
C:
[5-332]
M
H
A
I
E
V
T
--
E
T
G
G
P
-
G
-
V
L
R
H
V
-
D
Q
-
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
Q
----------------
Y
P
------------------------
R
E
L
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
T
AADT
A
I
S
V
G
D
R
V
V
S
----------------------------
A
---
S
-----------------------------
A
---------------------------
N
------------------------
G
A
Y
A
E
F
C
T
A
P
A
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
--
A
S
A
L
L
K
G
L
T
A
H
Y
L
L
K
S
--
V
--
Y
--
P
---
V
K
-----
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
R
V
I
T
T
V
S
-
T
A
E
K
A
-
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
---------------
F
----------------------
A
-------
G
--------------------------
R
------------------
V
----
R
E
L
T
G
G
T
G
---------
V
Q
A
V
-----
Y
D
G
V
G
A
T
T
-
F
D
A
---
S
L
A
S
L
A
V
R
G
T
L
A
L
----------
F
G
A
A
--------
S
G
P
VP-
P
---
V
D
P
---
Q
----
R
L
N
A
A
G
S--
V
Y
L
T
R
P
S
L
F
H
F
T
R-
T
--------
G
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
S
E
A
I
T
V
A
V
G
G
R
Y
--
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
K
-
T
-
V
G
S
V
V
L
L
P
--
10
PsiBlast_PDB
74.31
26%
4
- C1 -
-
5K1S
-
?
A:
[18-357]
M
K
A
V
V
L
R
--
S
F
G
E
A
G
N
-
L
K
M
E
T
-
M
P
M
P
R
-
P
-
G
R
G
E
V
L
L
R
V
H
A
C
G
V
C
Y
H
D
V
I
N
R
R
G
N
----------------
L
P
---------------
R
-------
T
-
S
V
P
A
I
L
G
H
E
A
A
G
E
V
I
E
V
G
P
D
T
P
----
G
W
K
T
G
D
R
A
A
T
L
QRMSCGDC
A
L
C
R
S
GRNSLCKTDNRFFG
E
---
E
-----------------------------
L
---------------------------
P
------------------------
G
G
Y
A
Q
F
M
V
A
P
V
G
G
L
G
R
V
P
A
S
L
P
W
N
E
A
--
A
T
V
C
C
T
T
G
T
A
V
H
T
V
R
T
--
R
--
G
--
K
---
V
R
-----
A
G
E
T
V
L
I
T
G
A
S
G
G
V
G
L
S
S
V
Q
L
A
R
L
D
G
A
R
V
I
A
V
T
S
-
S
---
E
-
A
K
V
Q
A
L
-
K
E
A
G
A
D
E
V
I
V
S
-----------------
R
----------------------
G
-------
L
--------------------------
D
------------------
F
----
A
-----
S
D
V
R
K
R
T
QGAG
V
D
V
A
-----
V
E
I
V
-
G
S
A
T
F
D
Q
---
T
L
K
S
M
A
P
G
G
R
V
V
V
----------
V
G
N
L
ESGMVQLN
P
G
L
---
V
---
I
V
K
---
E
----
L
---
E
----
I
L
G
---
A
-
Y
A
T
T
--
Q
--------
A
E
L
D
-
E
A
----
L
R
L
T
A
T
G
G
V
R
Q
F
V
T
D
--
A
V
P
L
A
E
A
A
K
A
H
F
R
L
E
N
-
R
E
V
-
A
G
R
L
V
L
----
46
HHSearch
73.94
22%
-22
- C1 -
-
4DUP
-
?
A:
[7-331]
M
R
F
V
D
L
K
--
S
F
G
G
P
-
D
-
V
M
V
I
G
-
K
R
-
P
L
P
V
A
G
E
G
E
V
L
V
R
A
E
A
I
G
V
N
R
P
D
I
A
Q
R
Q
G
S
----------------
Y
P
P
----------------------
P
K
D
A
S
P
I
L
G
L
E
L
S
G
E
I
V
G
V
G
P
G
V
S
----
G
Y
A
V
G
D
K
V
C
G
----------------------------
L
---
A
-----------------------------
N
---------------------------
G
------------------------
G
A
Y
A
E
Y
C
L
L
P
A
G
Q
I
L
P
F
P
K
G
Y
D
A
V
K
A
--
A
A
L
P
E
T
F
F
T
V
W
A
N
L
F
Q
--
M
--
A
--
G
---
L
T
-----
E
G
E
S
V
L
I
H
G
G
T
S
G
I
G
T
T
A
I
Q
L
A
R
A
F
G
A
E
V
Y
A
T
A
G
-
S
T
G
K
C
-
E
A
C
E
R
L
G
A
K
R
G
I
N
Y
R
S
E
D
-----------------
F
----------------------
A
-------
A
--------------------------
V
------------------
I
K
A
E
T
G
-----
Q
G
---------
V
D
I
I
-----
L
D
M
I
G
A
A
Y
-
F
E
R
---
N
I
A
S
L
A
K
D
G
C
L
S
I
----------
I
A
F
L
--------
G
G
A
VAE
K
---
V
N
L
S
P
I
M
----
V
---
K
R
---
L
T
V
T
--
G
-
S
T
M
R
--
P
RT
A
E
E
K
--
R
A
I
R
D
D
L
L
S
E
V
W
P
L
L
E
A
G
T
V
A
P
V
I
H
K
V
F
--
A
F
E
D
V
A
D
A
H
R
L
L
E
E
G
S
-
H
-
V
G
K
V
M
L
T
V
--
13
PsiBlast_PDB
73.45
24%
-19
- C1 -
-
1WLY
-
CAA43_BURSP
A:
[17-329]
-----------------
V
W
E
E
V
-
K
V
--
G
-
S
P
G
P
G
Q
V
R
L
R
N
T
A
I
G
V
N
F
L
D
T
Y
H
R
A
----------------------------------------------
P
P
I
V
V
G
F
E
A
A
A
V
V
E
E
V
G
P
G
V
T
----
D
F
T
V
G
E
R
V
C
T
----------------------------
C
---
L
-----------------------------
P
---------------------------
P
L-----------------------
G
A
Y
S
Q
E
R
L
Y
P
A
E
K
L
I
K
V
P
K
D
L
D
L
D
D
V
H
L
A
G
L
M
L
K
G
M
T
A
Q
Y
L
L
H
Q
--
T
--
H
--
K
---
V
K
-----
P
G
D
Y
V
L
I
H
A
A
A
G
G
M
G
H
I
M
V
P
W
A
R
H
L
G
A
T
V
I
G
T
V
S
-
T
-
E
E
K
A
E
T
A
R
K
L
G
C
H
H
T
I
N
Y
S
T
Q
D
----------------------------------------------------------------------------------------------
F
----
A
-----
E
V
---------
V
R
E
I
T
G
GKG
V
D
V
V
Y
D
S
I
G
K
D
T
L
Q
K
S
L
D
C
L
R
P
R
G
M
C
A
A
YGHASGVADP
I
R
V
V
--------
E
D
L
---
G
---
V
R
G
---
S
L
F
I
T
R
---
P
A
---
L
W
H
---
Y
-
M
S
N
R
--
S
--------
E
-
I
D
-
E
G
S
K
C
L
F
D
A
V
K
A
G
V
L
H
S
S
V
A
K
T
F
--
P
L
R
E
A
A
A
A
H
K
Y
M
G
G
-
R
Q
T
-
I
G
S
I
V
L
----
53
HHSearch
73.10
23%
-7
- C1 -
-
1YB5
5
QOR_HUMAN
A:
[30-351]
M
R
A
V
R
V
F
--
E
F
G
G
P
-
E
-
V
L
K
L
R
S
D
I
-
A
V
P
I
P
K
D
H
Q
V
L
I
K
V
H
A
C
G
V
N
P
V
E
T
Y
I
R
S
G
T
----------------
Y
S
R
----------------------
K
P
L
L
P
Y
T
P
G
S
D
V
A
G
V
I
E
A
V
G
D
N
A
S
----
A
F
K
K
G
D
R
V
F
T
----------------------------
S
---
S
T----------------------------
I
---------------------------
S
------------------------
G
G
Y
A
E
Y
A
L
A
A
D
H
T
V
Y
K
L
P
E
K
L
D
F
K
Q
G
--
A
A
I
G
I
P
Y
F
T
A
Y
R
A
L
I
H
--
S
--
A
--
C
---
V
K
-----
A
G
E
S
V
L
V
H
G
A
S
G
G
V
G
L
A
A
C
Q
I
A
R
A
Y
G
L
K
I
L
G
T
A
G
-
T
E
E
G
Q
-
K
I
V
L
Q
N
G
A
H
E
V
F
N
H
R
E
V
N
-----------------
Y
----------------------
I
-------
D
--------------------------
K
------------------
I
----
K
K
Y
V
GE
K
G
---------
I
D
I
I
-----
I
E
M
L
A
N
V
N
-
L
S
K
---
D
L
S
L
L
S
H
G
G
R
V
I
V
----------
V
G
S
R
--------
G
T
I
---
E
I
N
P
R
D
T
---
M
----
A
---
K
E
---
S
S
I
I
--
G
-
V
T
L
F
SS
T
--------
K
E
E
F
Q
Q
Y
A
A
A
L
Q
A
G
M
E
I
G
W
L
K
P
V
I
G
S
Q
Y
--
P
L
E
K
V
A
E
A
H
E
N
I
I
H
G
S
G
A
-
T
G
K
M
I
L
L
L
--
51
HHSearch
72.78
22%
8
- C1 -
-
4J6F
2
?
A:
[34-382]
M
T
A
V
L
L
T
--
G
H
G
G
L
-
E
-
K
L
V
Y
S
R
D
V
-
P
V
P
A
P
A
A
G
E
V
L
I
K
V
T
A
C
G
M
N
N
T
D
V
W
V
R
E
G
A
----------------
Y
G
T
E
DDPSAVSTWRRHG
N
-------
T
L
T
F
P
R
I
Q
G
T
D
T
V
G
H
I
V
A
V
G
E
G
V
D
----
R
A
R
I
G
E
R
V
M
V
----------------------------
D
---
F
SIYNRDDDSLAD
I
D
Y
M
GHG----------
R
---------------------------
D
------------------------
G
G
Y
A
E
Y
M
A
L
P
A
E
N
A
H
V
V
A
T
D
L
T
D
I
E
L
--
A
T
F
C
C
A
Y
L
T
G
E
R
M
L
E
R
-----
A
--
R
---
L
A
-----
A
G
E
T
V
L
V
T
G
A
S
G
G
V
G
S
A
I
I
Q
L
A
R
A
R
G
A
V
P
I
A
V
A
G
-
P
-
G
K
E
-
A
A
M
L
D
I
G
A
Q
A
V
V
T
R
G
Q
G
D
-----------------
L
----------------------
A
-------
E
--------------------------
A
------------------
V
----
E
A
A
S
GG
R
P
---------
I
D
V
V
-----
A
D
L
V
G
G
P
L
-
F
N
D
---
L
L
K
I
L
R
P
E
G
R
Y
T
T
----------
A
G
A
I
--------
A
G
P
V
V
-
Q
---
L
D
L
---
R
T
M
Y
-
L
---
K
Q
---
L
E
L
---
H
----
G
--
S
--------
S
Q
G
S
R
A
D
F
R
R
L
V
R
Y
I
E
E
K
K
I
R
P
L
V
G
G
V
Y
--
P
L
S
E
F
H
R
A
Q
T
D
F
M
A
K
N
-
F
-
V
G
K
L
V
V
V
P
D
-
40
HHSearch
71.58
23%
-11
- C1 -
-
4Y1B
1
?
A:
[67-423]
-----------------------------
P
V
G
P
G
Q
V
L
V
K
V
M
A
A
G
V
N
Y
N
N
V
W
A
A
L
G
E
----------------
P
L
D
V
-------------
I
A
A
R
Q
K
Q
G
A
T
E
D
F
H
I
G
G
S
D
L
S
G
I
V
W
A
V
G
D
G
V
-----
R
L
K
P
G
A
E
V
V
V
----------------------------
L
---
A
C
R
W
D
ESA
Q
D
I
R
L
GADPVTSST
Q
R
V
W
GYEE
N
---------------------------
Y
------------------------
G
S
F
A
Q
F
A
V
V
D
E
Y
M
C
H
P
K
P
Q
R
L
S
W
A
A
A
--
S
C
Y
M
A
T
A
A
T
A
Y
R
Q
L
F
G
--
W
EP
H
--
T
---
V
R
-----
P
G
D
P
V
L
I
W
G
G
A
G
G
L
G
S
I
A
I
Q
L
V
R
H
V
G
G
I
P
V
A
V
V
S
-
S
E
E
R
G
-
E
F
C
M
R
L
G
A
K
G
W
I
D
R
R
E
F
D
-----------------
H
----------------------
W
-------
G
RLPDTTD
E
E
A
M
K
Q
W
L
D
G
A
R
A
F
G
R
R
F
W
E
V
-----------------
L
GE--
R
-----
R
A
---------
P
R
I
V
-----
L
E
H
S
G
A
D
T
-
I
P
T
---
S
I
Y
M
A
D
N
A
G
M
V
V
I
----------
C
G
G
T
--------
T
G
Y
NG-
D
---
V
D
L
R
F
L
W
----
M
---
R
Q
---
K
R
L
---
Q
----
G
--
S
--------
H
A
A
S
A
R
E
A
R
E
I
T
R
L
I
D
Q
G
A
I
D
P
C
L
S
R
T
F
--
G
F
E
E
I
G
L
A
H
Q
L
I
H
D
N
Q
-
H
P
S
G
N
M
A
V
L
V
N
-
52
HHSearch
71.57
22%
10
- C1 -
-
4J6F
2
?
B:
[34-382]
M
T
A
V
L
L
T
--
G
H
G
G
L
-
E
-
K
L
V
Y
S
R
D
V
-
P
V
P
A
P
A
A
G
E
V
L
I
K
V
T
A
C
G
M
N
N
T
D
V
W
V
R
E
G
A
----------------
Y
G
T
E
DDPSAVSTWRRHG
N
-------
T
L
T
F
P
R
I
Q
G
T
D
T
V
G
H
I
V
A
V
G
E
G
V
D
----
R
A
R
I
G
E
R
V
M
V
----------------------------
D
---
F
SIYNRDDDSLAD
I
D
Y
M
GHG----------
R
---------------------------
D
------------------------
G
G
Y
A
E
Y
M
A
L
P
A
E
N
A
H
V
V
A
T
D
L
T
D
I
E
L
--
A
T
F
C
C
A
Y
L
T
G
E
R
M
L
E
R
-----
A
--
R
---
L
A
-----
A
G
E
T
V
L
V
T
G
A
S
G
G
V
G
S
A
I
I
Q
L
A
R
A
R
G
A
V
P
I
A
V
A
G
-
P
-
G
K
E
-
A
A
M
L
D
I
G
A
Q
A
V
V
T
R
G
Q
G
D
-----------------
L
----------------------
A
-------
E
--------------------------
A
------------------
V
----
E
A
A
S
GG
R
P
---------
I
D
V
V
-----
A
D
L
V
G
G
P
L
-
F
N
D
---
L
L
K
I
L
R
P
E
G
R
Y
T
T
----------
A
G
A
I
--------
A
G
P
V
V
-
Q
---
L
D
L
---
R
T
M
Y
-
L
---
K
Q
---
L
E
L
---
H
----
G
--
S
--------
S
Q
G
S
R
A
D
F
R
R
L
V
R
Y
I
E
E
K
K
I
R
P
L
V
G
G
V
Y
--
P
L
S
E
F
H
R
A
Q
T
D
F
M
A
K
N
-
F
-
V
G
K
L
V
V
V
P
D
-
36
HHSearch
71.09
22%
-3
* C1 *
-
4GI2
1
?
A:
[35-411]
M
Y
A
W
A
I
R
RE
R
H
G
P
P
-
E
Q
S
H
Q
L
E
-
V
L
-
P
V
W
E
I
G
D
D
E
V
L
V
Y
V
M
A
A
G
V
N
Y
N
G
V
W
A
G
L
G
E
----------------
P
I
S
P
FD-----------
V
-------
H
K
G
E
Y
H
I
A
G
S
D
A
S
G
I
V
W
K
V
G
A
K
V
K
----
R
W
K
V
G
D
E
V
I
V
----------------------------
H
---
C
NQDDGDDEECNGGDPMFSPT
Q
R
I
W
GYET-
G
---------------------------
D
------------------------
G
S
F
A
Q
F
C
R
V
Q
S
R
Q
L
M
A
R
P
K
H
L
T
W
E
E
A
--
A
C
Y
T
L
T
L
A
T
A
Y
R
M
L
F
G
--
H
--
A
PH
T
---
V
R
-----
P
G
Q
N
V
L
I
W
G
A
S
G
G
L
G
V
F
G
V
Q
L
C
A
A
S
G
A
N
A
I
A
V
I
S
-
D
E
S
K
R
-
D
Y
V
M
S
L
G
A
K
G
V
I
N
R
K
D
F
D
-----------------
C
WGQLPTVNS
P
E
Y
N
T
W
L
K
E
A
R
K
F
G
-------
K
A
I
W
-----------------------
D
------------------
I
TGK-
G
-----
N
D
---------
V
D
I
V
-----
F
E
H
P
G
E
A
T
-
F
P
V
---
S
T
L
V
A
K
R
G
G
M
I
V
F
----------
C
A
G
T
--------
T
G
F
---
N
I
T
-
F
D
A
R
Y
V
W
----
M
---
R
Q
---
K
R
I
Q
--
G
-
S
-
H
-------------
F
A
H
L
K
Q
A
S
A
A
N
Q
F
V
M
D
R
R
V
D
P
C
M
S
E
V
F
--
P
W
D
K
I
P
A
A
H
T
K
M
W
K
N
Q
H
P
-
P
G
N
M
A
V
L
V
N
-
5
PsiBlast_PDB
70.22
30%
-19
- C1 -
-
2EIH
-
?
A:
[1-260]
M
R
A
V
V
M
R
--
A
R
G
-
G
P
E
-
V
L
E
V
A
-
D
L
P
V
P
-
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
V
----------------
A
S
P
----------------------
K
L
P
L
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
E
----
G
F
A
P
G
D
E
V
V
I
----------------------------
N
PGL
S
-----------------------------
C
---------------------------
G
RC
E
R
C
L
A
GEDNLCPRYQILGEHRH
G
T
Y
A
E
Y
V
V
L
P
E
A
N
L
A
P
K
P
K
N
L
S
F
E
E
A
--
A
A
I
P
L
T
F
L
T
A
W
Q
M
V
V
D
--
K
--
L
--
G
---
V
R
-----
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
G
A
R
V
I
A
T
A
G
-
S
-
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
--
T
H
-----------------
P
----------------------
D
W
P
K
E
V
R
R
L
--------------------------
T
------------------
G
----
G
-----
K
G
---------
A
D
K
V
-----
V
D
H
T
-
G
A
L
Y
F
E
G
---
V
I
K
A
T
A
N
G
G
R
-----------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
69.97
22%
-2
- C1 -
-
4GI2
1
?
B:
[35-411]
M
Y
A
W
A
I
R
RE
R
H
G
P
P
-
E
Q
S
H
Q
L
E
-
V
L
-
P
V
W
E
I
G
D
D
E
V
L
V
Y
V
M
A
A
G
V
N
Y
N
G
V
W
A
G
L
G
E
----------------
P
I
S
P
FD-----------
V
-------
H
K
G
E
Y
H
I
A
G
S
D
A
S
G
I
V
W
K
V
G
A
K
V
K
----
R
W
K
V
G
D
E
V
I
V
----------------------------
H
---
C
NQDDGDDEECNGGDPMFSPT
Q
R
I
W
GYET-
G
---------------------------
D
------------------------
G
S
F
A
Q
F
C
R
V
Q
S
R
Q
L
M
A
R
P
K
H
L
T
W
E
E
A
--
A
C
Y
T
L
T
L
A
T
A
Y
R
M
L
F
G
--
H
--
A
PH
T
---
V
R
-----
P
G
Q
N
V
L
I
W
G
A
S
G
G
L
G
V
F
G
V
Q
L
C
A
A
S
G
A
N
A
I
A
V
I
S
-
D
E
S
K
R
-
D
Y
V
M
S
L
G
A
K
G
V
I
N
R
K
D
F
D
-----------------
C
WGQLPTVNS
P
E
Y
N
T
W
L
K
E
A
R
K
F
G
-------
K
A
I
W
-----------------------
D
------------------
I
TGK-
G
-----
N
D
---------
V
D
I
V
-----
F
E
H
P
G
E
A
T
-
F
P
V
---
S
T
L
V
A
K
R
G
G
M
I
V
F
----------
C
A
G
T
--------
T
G
F
---
N
I
T
-
F
D
A
R
Y
V
W
----
M
---
R
Q
---
K
R
I
Q
--
G
-
S
-
H
-------------
F
A
H
L
K
Q
A
S
A
A
N
Q
F
V
M
D
R
R
V
D
P
C
M
S
E
V
F
--
P
W
D
K
I
P
A
A
H
T
K
M
W
K
N
Q
H
P
-
P
G
N
M
A
V
L
V
N
-
54
HHSearch
69.18
23%
16
- C1 -
-
5A4D
4
QORH_ARATH
A:
[6-329]
M
H
A
L
Q
Y
N
--
S
Y
G
G
G
A
A
-
G
L
E
H
V
-
Q
V
-
P
V
P
T
P
K
S
N
E
V
C
L
K
L
E
A
T
S
L
N
P
V
D
W
K
I
Q
K
G
M
----------------
I
R
P
F
-------------
L
-------
P
R
K
F
P
C
I
P
A
T
D
V
A
G
E
V
V
E
V
G
S
G
V
K
----
N
F
K
A
G
D
K
V
V
A
----------------------------
V
---
L
-----------------------------
S
HLG------------------------
G
------------------------
G
G
L
A
E
F
A
V
A
T
E
K
L
T
V
K
R
P
Q
E
V
G
A
A
E
A
--
A
A
L
P
V
A
G
L
T
A
L
Q
A
L
T
N
--
P
--
A
--
G
---
L
K
LDGTG
K
K
A
N
I
L
V
T
A
A
S
G
G
V
G
H
Y
A
V
Q
L
A
K
L
A
N
A
H
V
T
A
T
C
G
-
A
-
R
N
I
-
E
F
V
K
S
L
G
A
D
E
V
L
D
Y
K
T
P
E
-----------------
G
A
A
--------------------
L
-------
K
--------------------------
S
------------------
P
S---
G
-----
K
K
---------
Y
D
A
V
-----
V
H
C
A
N
G
I
P
-
F
S
V
---
F
E
P
N
L
S
E
N
G
K
V
I
D
----------
I
T
P
G
--------
P
N
A
---
M
---
W
T
Y
---
A
----
V
---
K
K
---
I
T
M
S--
K
-
K
Q
L
V
--
P
L
L
------
L
I
P
K
A
E
N
L
E
F
M
V
N
L
V
K
E
G
K
V
K
T
V
I
D
S
K
H
--
P
L
S
K
A
E
D
A
W
A
K
S
I
D
G
H
-
A
-
T
G
K
I
I
V
E
P
--
43
HHSearch
68.99
23%
11
- C1 -
-
4A0S
4
?
B:
[50-414]
------------------
L
R
L
G
-
E
V
-
P
M
P
E
L
A
P
D
E
V
L
V
A
V
M
A
S
S
I
N
Y
N
T
V
W
S
A
M
F
E
PIPTFHFLKQNARQGG
W
A
T
--------------
R
-------
H
D
Q
P
Y
H
V
L
G
S
D
C
S
G
V
V
V
R
T
G
I
G
V
R
----
R
W
K
P
G
D
H
V
I
V
----------------------------
H
---
P
-----------------------------
A
HVDEQEPATHGDGMLGTEQRAWGFETN
F
------------------------
G
G
L
A
E
Y
G
V
V
R
A
S
Q
L
L
P
K
P
A
H
L
T
W
E
E
A
--
A
V
S
P
L
C
A
G
T
A
Y
R
M
L
V
S
DR
G
--
A
--
Q
---
M
K
-----
Q
G
D
I
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
I
Q
F
V
K
N
G
G
G
I
P
V
A
V
V
S
-
S
A
Q
K
E
-
A
A
V
R
A
L
G
C
D
L
V
I
N
R
A
E
L
G
-----------------
I
----------------------
T
-------
D
--------------------------
D
IADDPRRVVETGRKLAKL
V
VEK-
A
G----
R
E
---------
P
D
I
V
-----
F
E
H
T
G
R
V
T
-
F
G
L
---
S
V
I
V
A
R
R
G
G
T
V
V
T
----------
C
G
S
S
--------
S
G
Y
LH-
T
---
F
D
N
RYL
W
----
M
---
K
L
---
K
K
I
---
V
-
G
-
S
------------
H
G
A
N
H
E
E
Q
Q
A
T
N
R
L
F
E
S
G
A
V
V
P
A
M
S
A
V
Y
--
P
L
A
E
A
A
E
A
C
R
V
V
Q
T
S
R
-
Q
-
V
G
K
V
A
V
L
C
M
-
49
HHSearch
68.92
25%
24
- C1 -
-
5K1S
-
?
C:
[18-360]
M
K
A
V
V
L
R
--
S
F
G
E
A
-
G
-
N
L
K
M
E
-
T
M
-
P
M
P
R
P
G
R
G
E
V
L
L
R
V
H
A
C
G
V
C
Y
H
D
V
I
N
R
R
G
N
----------------
L
P
-----------------------
R
T
S
V
P
A
I
L
G
H
E
A
A
G
E
V
I
E
V
G
P
D
T
P
----
G
W
K
T
G
D
R
A
A
T
----------------------------
L
---
Q
RMSCGDCALCRSGRNSLCKTDNR
F
F
G
E
E
-
L
---------------------------
P
------------------------
G
G
Y
A
Q
F
M
V
A
P
V
G
G
L
G
R
V
P
A
S
L
P
W
N
E
A
--
A
T
V
C
C
T
T
G
T
A
V
H
T
V
R
T
--
R
--
G
--
K
---
V
R
-----
A
G
E
T
V
L
I
T
G
A
S
G
G
V
G
L
S
S
V
Q
L
A
R
L
D
G
A
R
V
I
A
V
T
S
-
S
E
A
K
V
-
Q
A
L
K
E
A
G
A
D
E
V
I
V
S
R
G
L
D
-----------------
F
----------------------
A
-------
S
--------------------------
D
------------------
V
RKRT
Q
G----
A
G
---------
V
D
V
A
-----
V
E
I
V
G
S
A
T
-
F
D
Q
---
T
L
K
S
M
A
P
G
G
R
V
V
V
----------
V
G
N
L
--------
E
S
G
---
M
V
Q
-
L
N
P
---
G
----
L
V
I
V
K
E
---
L
E
I
-------
L
G
--
A
--------
Y
A
T
T
Q
A
E
L
D
E
A
L
R
L
T
A
T
G
G
V
R
Q
F
V
T
D
A
V
--
P
L
A
E
A
A
K
A
H
F
R
L
E
N
R
E
-
V
-
A
G
R
L
V
L
V
P
P
-
50
HHSearch
68.62
25%
23
- C1 -
-
5K1S
-
?
D:
[18-360]
M
K
A
V
V
L
R
--
S
F
G
---
G
-
N
L
K
M
E
-
T
M
-
P
M
P
R
P
G
R
G
E
V
L
L
R
V
H
A
C
G
V
C
Y
H
D
V
I
N
R
R
G
-------------------------------------------------
L
G
H
E
A
A
G
E
V
I
E
V
G
P
D
T
P
----
G
W
K
T
G
D
R
A
A
T
----------------------------
L
---
Q
RMSCGDCALCRSGRNSLCKTDNRFFGEE-
L
---------------------------
P
------------------------
G
G
Y
A
Q
F
M
V
A
P
V
G
G
L
G
R
V
P
A
S
L
P
W
N
E
A
--
A
T
V
C
C
T
T
G
T
A
V
H
T
V
R
T
--
R
--
G
--
K
---
V
R
-----
A
G
E
T
V
L
I
T
G
A
S
G
G
V
G
L
S
S
V
Q
L
A
R
L
D
G
A
R
V
I
A
V
T
S
-
S
E
A
K
V
-
Q
A
L
K
E
A
G
A
D
E
V
I
V
S
R
G
L
D
-----------------
F
----------------------
A
-------
S
--------------------------
D
------------------
V
RKRT
Q
G----
A
G
---------
V
D
V
A
-----
V
E
I
V
G
S
A
T
-
F
D
Q
---
T
L
K
S
M
A
P
G
G
R
V
V
V
----------
V
G
N
L
--------
E
S
G
---
M
VQ-
L
N
P
---
G
----
L
VIV
K
E
---
L
E
I
-------
L
G
--
A
--------
Y
A
T
T
Q
A
E
L
D
E
A
L
R
L
T
A
T
G
G
V
R
Q
F
V
T
D
A
V
--
P
L
A
E
A
A
K
A
H
F
R
L
E
N
R
E
-
V
-
A
G
R
L
V
L
V
P
P
-
42
HHSearch
68.14
23%
11
- C1 -
-
4A0S
4
?
C:
[50-414]
------------------
L
R
L
G
-
E
V
-
P
M
P
E
L
A
P
D
E
V
L
V
A
V
M
A
S
S
I
N
Y
N
T
V
W
S
A
M
F
E
PIPTFHFLKQNARQGG
W
A
T
--------------
R
-------
H
D
Q
P
Y
H
V
L
G
S
D
C
S
G
V
V
V
R
T
G
I
G
V
R
----
R
W
K
P
G
D
H
V
I
V
----------------------------
H
---
P
-----------------------------
A
HVDEQEPATHGDGMLGTEQRAWGFETN
F
------------------------
G
G
L
A
E
Y
G
V
V
R
A
S
Q
L
L
P
K
P
A
H
L
T
W
E
E
A
--
A
V
S
P
L
C
A
G
T
A
Y
R
M
L
V
S
DR
G
--
A
--
Q
---
M
K
-----
Q
G
D
I
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
I
Q
F
V
K
N
G
G
G
I
P
V
A
V
V
S
-
S
A
Q
K
E
-
A
A
V
R
A
L
G
C
D
L
V
I
N
R
A
E
L
G
-----------------
I
----------------------
T
-------
D
--------------------------
D
IADDPRRVVETGRKLAKL
V
VEK-
A
G----
R
E
---------
P
D
I
V
-----
F
E
H
T
G
R
V
T
-
F
G
L
---
S
V
I
V
A
R
R
G
G
T
V
V
T
----------
C
G
S
S
--------
S
G
Y
LH-
T
---
F
D
N
RYL
W
----
M
---
K
L
---
K
K
I
---
V
-
G
-
S
------------
H
G
A
N
H
E
E
Q
Q
A
T
N
R
L
F
E
S
G
A
V
V
P
A
M
S
A
V
Y
--
P
L
A
E
A
A
E
A
C
R
V
V
Q
T
S
R
-
Q
-
V
G
K
V
A
V
L
C
M
-
55
HHSearch
67.61
23%
14
- C1 -
-
5A3V
-
QORH_ARATH
B:
[6-329]
M
H
A
L
Q
Y
N
--
S
Y
G
G
G
A
A
-
G
L
E
H
V
-
Q
V
-
P
V
P
T
P
K
S
N
E
V
C
L
K
L
E
A
T
S
L
N
P
V
D
W
K
I
Q
K
G
M
----------------
I
R
P
F
-------------
L
-------
P
R
K
F
P
C
I
P
A
T
D
V
A
G
E
V
V
E
V
G
S
G
V
K
----
N
F
K
A
G
D
K
V
V
A
----------------------------
V
---
L
-----------------------------
S
HLG------------------------
G
------------------------
G
G
L
A
E
F
A
V
A
T
E
K
L
T
V
K
R
P
Q
E
V
G
A
A
E
A
--
A
A
L
P
V
A
G
L
T
A
L
Q
A
L
T
N
--
P
--
A
--
G
---
L
K
LDGTG
K
K
A
N
I
L
V
T
A
A
S
G
G
V
G
H
Y
A
V
Q
L
A
K
L
A
N
A
H
V
T
A
T
C
G
-
A
-
R
N
I
-
E
F
V
K
S
L
G
A
D
E
V
L
D
Y
K
T
P
E
-----------------
G
A
A
--------------------
L
-------
K
--------------------------
S
------------------
P
S---
G
-----
K
K
---------
Y
D
A
V
-----
V
H
C
A
N
G
I
P
-
F
S
V
---
F
E
P
N
L
S
E
N
G
K
V
I
D
----------
I
T
P
G
--------
P
N
A
---
M
---
W
T
Y
---
A
----
V
---
K
K
---
I
T
M
S--
K
-
K
Q
L
V
--
P
L
L------
L
I
P
K
A
E
N
L
E
F
M
V
N
L
V
K
E
G
K
V
K
T
V
I
D
S
K
H
--
P
L
S
K
A
E
D
A
W
A
K
S
I
D
G
H
-
A
-
T
G
K
I
I
V
E
P
--
32
Fugue
66.59
21%
-19
- C1 -
-
1O89
-
ACUI_ECOLI
A:
[1-323]
L
Q
A
L
L
L
E
--
Q
----
Q
T
-
L
A
S
V
Q
-
T
L
D
E
S
-
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
K
----------------
G
K
I
I
-------------
R
---------
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
D
P
------
R
F
H
A
G
Q
E
V
L
L
----------------------------
T
---
G
-----------------------------
W
---------------------------
G
VGENHW------------------
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
--
M
I
I
G
T
A
G
F
T
A
M
L
C
V
M
A
--
L
--
E
--
D
A
GV
R
P
-----
Q
D
G
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
Q
V
V
A
V
S
G
R
E
-
S
T
H
-
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
F
A
-----------------
E
----------------------
S
-------
R
--------------------------
P
------------------
L
E---
K
-----
Q
V
---------
W
A
G
A
-----
I
D
T
V
G
D
K
V
L
A
K
V
----
L
A
Q
M
N
Y
G
G
C
V
A
A
----------
C
G
L
A
--------
G
G
F
---
T
---
L
P
T
---
T
----
V
---
M
P
---
F
I
L
---
R
-
N
V
R
L
--
Q
G
V
D
SVMTP
P
E
R
R
A
Q
A
W
Q
R
L
V
A
D
L
P
E
S
F
Y
T
---
Q
A
A
K
E
I
S
L
S
E
A
P
N
F
A
E
A
I
I
N
-
N
Q
I
-
Q
G
R
T
L
V
K
V
--
39
HHSearch
65.18
25%
-0
- C1 -
-
3KRT
-
?
D:
[67-420]
-----------------------------
E
L
G
P
G
E
A
L
V
A
V
M
A
S
S
V
N
Y
N
S
V
H
T
S
I
F
E
PLSTFGFLERYGR---
V
S
D
L
AK-----------
R
-------
H
D
L
P
Y
H
V
I
G
S
D
L
A
G
V
V
L
R
T
G
P
G
V
N
----
A
W
Q
A
G
D
E
V
V
A
----------------------------
H
---
C
LSVELESSDGHNDTMLDPEQRIWGFET--
N
---------------------------
F
------------------------
G
G
L
A
E
I
A
L
V
K
S
N
Q
L
M
P
K
P
D
H
L
S
W
E
E
A
--
A
A
P
G
L
V
N
S
T
A
Y
R
Q
L
V
S
--
R
NG
A
--
G
---
M
K
-----
Q
G
D
N
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
T
Q
F
A
L
A
G
G
A
N
P
I
C
V
V
S
-
S
P
Q
K
A
-
E
I
C
R
A
M
G
A
E
A
I
I
D
R
N
A
E
G
YRFWKDENTQDPKEWKR
F
----------------------
G
-------
K
--------------------------
R
------------------
I
----
R
ELTGG
E
D
---------
I
D
I
V
-----
F
E
H
P
G
R
E
T
-
F
G
A
---
S
V
F
V
T
R
K
G
G
T
I
T
T
----------
C
A
S
T
--------
S
G
Y
---
M
HE-
Y
D
N
RYL
W
----
M
---
S
L
---
K
R
I
I--
G
-
S
-
H
-------------
F
A
N
Y
R
E
A
W
E
A
N
R
L
I
A
K
G
R
I
H
P
T
L
S
K
V
Y
--
S
L
E
D
T
G
Q
A
A
Y
D
V
H
R
N
L
-
H
-
Q
G
K
V
G
V
L
---