@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TYH4: (2017-12-14 )
MQSIKNTLRLYLLDWKRIFKNPIATLLIIAIMIIPSLYAWFNIKALWDPYGNTGELPIAVYSADKPAEFQGKEVAIGEQVIESLHKNKQLGWQFVDSKEQLEDGVRSGKYYAGIYLPKDFSEDLLSFTSGDIKKPKIEYTVNEKINAIAPKITDKGASSIQSQITNEFIKTASSTLLKVFNEIGYDIDTNLVSINKVKDMILSTDENLDTIDGYTKQVLELQSQLPEIKEKLNKANEFVDYIPKVDEMGEKVVALNDKMPELKDQAKIILDLQEKIPEIQNAGKQLAEIDGDFASIQETMNQGIDEAKQGLTIIQQVQDILPDVKNLENQASDLANQTKSGASQLKDAIPSITNSVDVTLKSIGQVATTTGSLIDTVRTAIEDGKLTDDEKKNISNVLNGFIDGISQQQNAIDKLVEFLTKLQTSAGNTKLQPIIDQLNQLKPLLSNLQNRLSALNTAVQNEDTKAIDELLDQIDAVVNNINGIIAGINTGQISSTVTSLLDQVIDTIGTAQGALSKADQIDFDSLLSSTKATVTNAVAILEKYQKEMPAIGQEIHDANTMLNGNMDTIVNGINEGADLYNNELPIIQQKLGLAADFIQNDWPALKNEITGTLTTVNEKMPEVETAVNAAADLINNDWPNIKAGIQKAADAIRKGEQEVDLGEVIKLLKLDATKESDFFTQPVELQTNALYPIANNGSASTPFYTALCLWVGAVLLSSVATTEYYLGKKDRNNFTKREQFVARMLTFLTMAIAQSLIVTLGNIFLLGVDVQNPVYSVSFAVLIALAFMMIVYVLAALFDNVGKGIAIIILVLSISGGGGNYPIQVSGKFFQMINPFLPFTHAVNLLRESAGGIYWPNATKAIWIMIGLFVVFGIVGTAIYPFIEEKMTKFKEAAHESHIFH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170....---------...180.......190.......200...------....210..--.....220..-.....-230.......240.......250......--.260.......270.....--...280.---......290-------.......300....-...310.......--.-320...-----.....330-------------------..-.....340.......--------350..-------.....360.......370.......380..--.....390.......400.......410-.......-..420.......--------.430-.........440.......450-........460.......470.-......480.....-..490.......500.......510.......520....--...530....----------...540.......550.......560.......570..----.....580.......590.......600.......610--.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720......---.730..-..-...740......-.750.......760.......770.-........780.......790.......800.......810.--.....-..-.820.......830...-....840.....-------..850..-------------------------..---------------------------------...860.......870.......880.......890.......900
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQ
S
I
K
N
T
L
R
L
Y
L
L
D
W
K
R
I
F
KN
P
I
A
T
L
L
I
I
A
I
M
I
I
P
S
L
Y
A
W
F
N
I
K
A
L
WDPYGNTGE
L
P
I
A
V
YSADKPAEFQGKEV
A
I
G
E
Q
V
I
E
S
L
H
KNKQL
G
W
Q
FVD
S
K
E
Q
L
E
D
G
V
RSG
K
Y
Y
A
G
I
YLPKD
F
S
E
D
L
L
S
FTSGDIKK
P
K
I
E
Y
T
VNEKINAIAPKITDK
G
A
S
S
I
Q
S
Q
I
T
N
E
F
I
K
T
A
S
S
T
L
---------
L
K
V
F
N
EIGYDIDTN
L
V
S
I
N
K
V
K
D
M
I
LSTD------ENLDT
I
D
G
Y
--
T
K
Q
V
L
E
L
Q
S
Q
-
L
P
E
I
K
-
E
K
L
N
K
A
N
E
F
V
D
YIP
K
V
D
E
MG
E
K
V
V
ALNDK--M
P
E
L
K
D
Q
A
K
I
I
L
D
-
L
Q
E
K
I
--
P
E
I
Q
N
A
G
---
K
Q
L
A
E
IDG
D
-------
F
A
S
I
Q
E
T
M
N
Q
G
I
D
E
-
A
K
Q
G
L
-
T
I
I
Q
Q
V
Q
--
D
-
I
-
L
P
D
V
-----
K
N
L
E
N
Q
A
S
-------------------
D
L
-
A
N
Q
T
K
S
G
A
S
Q
L
K
D
A
I
--------
P
S
ITN-------
S
V
D
V
T
L
K
SI
G
Q
V
ATT
T
G
S
L
I
D
T
V
R
T
A
IEDG--KLT
D
D
E
K
K
N
I
S
N
V
L
N
G
F
I
D
G
I
S
Q
Q
Q
N
---
A
I
D
K
L
V
E
-
F
L
T
-
K
L
QTSAGN--------T
K
---
L
Q
P
I
I
D
Q
L
N
Q
L
K
P
L
L
S
N
L
Q
N
R
--
L
S
A
L
N
T
A
VQNE
D
T
K
A
I
D
E
L
L
D
Q
-
I
D
A
V
V
N
NIN
G
I
I
AG-INT
G
Q
I
S
S
T
V
T
S
L
L
D
Q
V
I
D
T
IGTAQGALSKADQI
D
F
D
S
L
--
L
S
S
T
K
A
T
V
T
N
----------
A
V
A
I
L
E
K
Y
Q
K
EM
P
A
I
G
Q
E
IHDANTMLNG
N
M
D
T
I
V
N
G
I
N
----
E
G
A
D
LYNNEL
P
I
I
Q
Q
K
L
G
L
A
A
D
F
I
QND
W
P
A
L
K
N
EITG
T
--
L
T
T
VNEKMP
E
V
E
T
A
V
N
A
A
A
D
L
I
NNDWP
N
I
K
A
G
I
Q
K
A
A
D
A
I
RKGEQEV
D
L
G
E
V
I
K
L
L
KLDATKESDFFTQP
V
E
L
QTN
A
L
Y
P
IANNGSAS
T
P
F
Y
T
A
L
C
L
W
V
G
A
V
L
L
S
S
V
AT
T
E
YYLGK---KDRNN
F
-
T
K
-
R
E
Q
F
V
A
R
M
L
T
F
L
-
T
M
A
I
A
Q
S
L
I
V
T
LG
N
I
F
L
L
G
VDV--Q-NP
V
Y
S
V
S
F
A
V
L
I
A
L
A
F
M
M
I
V
Y
V
L
A
A
L
F
D
NVGK
G
I
A
I
I
I
L
--
V
--
L
S
I
SG-GG-GN
Y
P
I
Q
VS
G
K
F
F
Q
M
I
N
P
-FL
P
F
T
H
A
V
N
L
L
R
-------
E
SAGGIY-------------------------WP---------------------------------NA
T
K
A
I
W
I
M
I
G
L
F
V
V
F
G
I
V
G
T
A
I
Y
P
F
I
E
E
K
M
T
K
F
K
E
A
A
H
ESHIFH
38
Fugue
55.38
12%
-37
- C5 -
-
1V9D
-
DIAP1_MOUSE
A:
[6-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
L
K
V
L
D
---------
S
K
T
A
Q
N
L
S
I
F
L
G
S
F
R
M
P
Y
Q
E
I
K
N
V
I
L
E
V
N
------
E
A
V
L
T
------
E
S
M
I
Q
N
L
I
K
Q
-
M
P
E
-
P
-
E
Q
L
K
M
L
S
E
L
K
E
E
Y
D
D
L
A
E
S
E
Q
F
G
V
V
M
G
-
T
--
V
P
R
L
R
P
R
L
N
A
I
L
F
-
K
L
Q
F
S
--
E
Q
V
E
N
I
K
---
P
E
I
V
S
V
T
A
A
-------
C
E
E
L
R
K
S
--
E
N
F
S
S
-
L
L
S
F
L
-
C
K
L
R
D
T
K
--
S
-
A
-
D
Q
K
M
-----
T
L
L
H
F
L
A
E
-------------------
L
C
-
E
N
D
H
P
E
-
V
L
K
F
P
D
E
L
--------
A
H
V
E
K
-------
A
S
R
V
S
A
E
N
L
Q
K
S
L
D
Q
M
K
K
Q
I
A
D
V
E
R
D
V
Q
N
F
--
P
A
A
T
D
E
K
D
K
F
V
E
K
M
T
S
F
V
K
D
A
Q
E
Q
Y
N
---
K
L
R
M
M
H
S
-
N
M
E
-
T
L
Y
K
E
L
G
D
YFVFDPKK
L
S
---
V
E
E
F
F
M
D
L
H
N
F
R
N
M
F
L
Q
A
V
K
E
--
N
Q
K
R
R
E
T
E
E
K
M
R
R
A
K
L
A
K
E
K
A
E
-
K
E
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
54.24
24%
-166
- C4 -
-
2ZCM
-
ICAR_STAEQ
A:
[49-129]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
S
V
E
N
C
F
N
Y
F
I
D
F
M
-----Y--
S
I
D
G
L
Y
Q
-
F
L
F
-
K
F
I
F
D
V
D
E
--------
R
Y
---
I
K
L
Y
V
Q
L
S
S
A
P
E
A
L
N
S
E
I
K
H
H
--
L
Q
E
I
N
T
T
L
H
D
E
L
I
K
Y
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
53.80
15%
-158
* C3 *
-
5DO7
-
ABCG5_HUMAN
A:
[455-650]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
L
Y
-
Q
K
-
W
Q
M
M
L
A
Y
A
L
H
V
L
-
P
F
S
V
V
A
T
M
I
F
S
S
V
C
Y
W
T
L
G
L
H
P
E
V
A
-
R
F
G
Y
F
S
A
A
L
L
A
P
H
L
I
G
E
F
L
T
L
V
L
L
G
I
V
Q
N
P
N
I
V
N
S
V
V
A
L
--
L
S
I
A
G
V
L
V
G
S
G
-
F
L
R
N
I
Q
E
M
P
I
P
F
K
I
I
S
Y
-
F
T
F
Q
K
Y
C
S
E
I
L
V
-------
V
N
E
F
Y
G
L
N
------------------------
F
T
CAFTQ
G
I
Q
F
I
E
K
TCPGATS--------------
R
F
T
M
N
F
L
I
L
Y
S
F
I
P
A
L
V
I
L
G
I
V
V
F
K
I
R
D
H
L
I
S
-------------
24
HHSearch
52.91
15%
-141
- C3 -
-
5DO7
-
ABCG5_HUMAN
C:
[455-649]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
L
Y
-
Q
K
-
W
Q
M
M
L
A
Y
A
L
H
V
L
-
P
F
S
V
V
A
T
M
I
F
S
S
V
C
Y
W
T
L
G
L
H
P
E
V
A
-
R
F
G
Y
F
S
A
A
L
L
A
P
H
L
I
G
E
F
L
T
L
V
L
L
G
I
V
Q
N
P
N
I
V
N
S
V
V
A
L
--
L
S
I
A
G
V
L
V
G
S
G
-
F
L
R
N
I
Q
E
M
P
I
P
F
K
I
I
S
Y
-
F
T
F
Q
K
Y
C
S
E
I
L
V
-------
V
N
E
F
Y
G
L
N
------------------------
F
T
CGSMCAFTQ
G
I
Q
F
I
E
K
TCPGATS----------
R
F
T
M
N
F
L
I
L
Y
S
F
I
P
A
L
V
I
L
G
I
V
V
F
K
I
R
D
H
L
I
--------------
33
Fugue
51.55
15%
32
- C5 -
-
5I6J
-
SRGP2_HUMAN
A:
[8-481]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
D
--
K
E
I
I
A
E
Y
D
T
Q
-
V
K
E
I
R
-
A
Q
L
T
E
Q
M
K
C
L
D
-----
Q
Q
C
E
L
R
V
Q
L
L
Q
D
L
--
Q
D
F
F
R
K
K
A
E
I
E
M
D
-
Y
S
R
N
L
--
E
K
L
A
E
R
F
L
--
A
K
T
Q
N
V
L
S
P
-------
V
N
C
W
N
L
L
L
N
Q
V
K
R
E
-
S
R
D
H
T
-
T
L
S
D
I
Y
L
--
N
N
I
-
I
P
R
F
-----
V
Q
V
S
E
D
S
G
-------------------
R
L
-
F
K
K
S
K
E
V
G
Q
Q
L
Q
D
D
L
--------
M
K
V
L
N
-------
E
L
Y
S
V
M
K
T
Y
H
M
Y
N
A
D
S
I
S
A
Q
S
K
L
K
E
A
E
K
Q
E
V
K
K
I
E
K
M
K
E
K
R
Q
A
K
Y
T
E
N
K
L
K
A
I
K
A
R
N
E
---
Y
L
L
A
L
E
A
-
T
N
A
-
S
V
F
K
Y
Y
I
H
---------
D
---
L
S
D
L
I
D
Q
C
C
D
L
G
--
Y
H
A
S
L
N
R
--
A
L
R
T
F
L
S
A
E
L
N
L
E
Q
S
K
H
E
G
L
D
A
-
I
E
N
A
V
E
N
L
D
-----------
A
T
S
D
K
Q
R
L
M
E
M
Y
N
N
V
F
C
P
P
M
K
F
E
F
Q
P
H
M
G
D
M
A
S
Q
--
L
C
A
Q
Q
P
V
Q
S
E
----------
L
V
Q
R
C
Q
Q
L
Q
S
R
L
S
T
L
K
I
E
N
E
E
V
K
K
T
M
E
A
T
L
Q
T
I
Q
D
I
V
T
VEDF
D
V
S
D
C
F
Q
Y
K
-
P
S
I
A
K
R
R
A
N
Q
Q
E
T
E
Q
F
Y
F
T
K
M
K
E
Y
L
E
G
R
N
L
I
T
K
L
Q
A
K
H
D
L
L
Q
K
T
L
G
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.85
21%
76
- C3 -
-
3FFZ
-
BXE_CLOBO
A:
[427-759]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
I
N
N
G
E
L
---------
F
F
V
A
S
E
N
S
Y
N
-
D
D
N
I
N
T
P
K
E
I
D
D
T
V
T
S
N
-----------
D
L
D
-----
Q
V
I
L
N
F
N
S
E
S
A
P
G
L
S
D
E
K
L
N
L
T
I
Q
N
D
A
Y
I
P
K
Y
D
S
N
G
T
S
D
I
E
Q
H
D
---
V
N
E
L
--
N
V
F
F
Y
L
D
-
A
Q
-
K
V
--
P
E
G
E
N
N
V
---
N
L
T
S
S
I
D
T
A
L
L
E
Q
P
K
I
Y
T
F
F
S
S
E
F
I
N
N
V
N
K
-
P
V
Q
A
A
-
L
F
V
S
W
I
Q
--
Q
-
V
-
L
V
D
F
-----
T
T
E
A
N
Q
K
S
T
V
DKIADISIVVPY
I
G
L
A
L
N
I
-
G
N
E
A
Q
K
G
--
N
F
K
D
A
L
--------
E
L
L
G
A
-------
G
I
L
L
E
F
E
P
E
L
L
I
P
T
I
---
L
V
F
T
I
K
S
F
L
G
S
-----
S
D
N
K
N
K
V
I
K
A
I
N
N
A
L
K
E
R
D
E
K
W
K
E
---
V
Y
S
F
I
V
S
N
W
M
T
-
K
I
N
T
Q
F
N
K
--------
R
K
E
Q
M
Y
Q
A
L
Q
N
Q
V
N
A
I
K
T
I
I
E
S
K
Y
N
S
YT
L
E
E
K
N
E
L
T
N
K
Y
D
I
K
Q
I
E
N
E
L
N
Q
K
V
S
I
A
M
N
N
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
49.56
14%
-170
- C3 -
-
5NJ3
1
?
A:
[469-661]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
G
Y
-
Y
R
V
S
S
Y
F
L
G
K
L
L
S
D
L
L
P
M
R
M
L
P
S
I
I
F
T
C
I
V
Y
F
M
L
G
L
K
P
K
A
D
-
A
F
F
V
M
M
F
T
L
M
M
V
A
Y
S
A
S
S
M
A
L
A
I
A
A
G
Q
S
V
V
S
V
A
T
L
L
M
T
I
--
C
F
V
F
M
M
I
F
-
S
G
-
L
L
V
N
L
T
T
I
A
S
W
L
S
W
L
Q
Y
-
F
S
I
P
R
Y
G
F
T
A
L
Q
-------
H
N
E
F
L
G
Q
-------------------------
N
F
CPGLNATGNNPCNYATCT
G
E
E
Y
L
V
K
Q
GIDLS
P
W
G
L
W
K
N
H
V
A
L
A
C
M
I
V
I
F
L
T
I
A
Y
L
K
L
L
F
L
K
-----------------
14
PsiBlast_PDB
49.48
26%
-116
- C4 -
-
4PXU
1
KL61_DROME
A:
[24-142]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
H
K
---
A
M
L
D
S
M
Q
E
K
-------
F
A
T
I
I
D
S
S
L
Q
S
V
E
E
H
A
K
Q
M
H
-
K
K
L
E
Q
L
G
--
A
-
M
S
L
P
D
A
-----
E
E
L
Q
N
L
Q
E
-------------------
E
L
-
A
N
E
--
R
A
L
A
Q
Q
E
D
A
L
L
E
S
M
M
M
Q
M
E
Q
I
K
N
L
R
S
K
N
S
I
S
M
S
V
H
L
N
K
M
E
E
S
R
L
T
R
N
H
R
I
D
D
I
K
S
G
I
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
49.06
14%
-170
- C3 -
-
5NJG
1
?
B:
[469-661]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
G
Y
-
Y
R
V
S
S
Y
F
L
G
K
L
L
S
D
L
L
P
M
R
M
L
P
S
I
I
F
T
C
I
V
Y
F
M
L
G
L
K
P
KA
D
-
A
F
F
V
M
M
F
T
L
M
M
V
A
Y
S
A
S
S
M
A
L
A
I
A
A
G
Q
S
V
V
S
V
A
T
L
L
M
T
I
--
C
FV
F
M
M
I
F
-
S
G
-
L
L
V
N
L
T
T
I
A
S
W
L
S
W
L
Q
Y
-
F
S
I
P
R
Y
G
F
T
A
L
Q
-------
H
N
E
F
L
G
Q
-------------------------
N
F
CPGLNATGNNPCNYATCTGEEYLVKQGIDLSPW
G
L
W
K
N
H
V
A
L
A
C
M
I
V
I
F
L
T
I
A
Y
L
K
L
L
F
L
K
-----------------
21
HHSearch
48.47
15%
-138
- C3 -
-
5DO7
-
ABCG8_HUMAN
B:
[488-675]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
-
T
T
-
G
P
Y
F
F
A
K
I
L
G
E
L
-
P
E
H
C
A
Y
I
I
I
Y
G
M
P
T
Y
W
L
A
N
L
R
P
GL
Q
-
P
F
L
L
H
F
L
L
V
W
L
V
V
F
C
C
R
I
M
A
L
A
A
A
A
L
L
P
T
F
H
M
A
S
F
F
S
N
A
L
Y
N
--
S
F
Y
L
A
-
G
G
-
F
M
I
N
L
S
S
L
W
T
V
P
A
W
I
S
K
-
V
S
F
L
R
W
C
F
E
G
L
M
-------
K
I
Q
F
S
R
R
T
Y
K
M
P
L
G
NLTIAVSGD
K
I
L
S
V
M
ELD
S
Y
---------------------------------
P
L
Y
A
I
Y
L
I
V
I
G
L
S
G
G
F
M
V
L
Y
Y
V
S
L
R
F
I
K
Q
K
P
S
Q
D
W
----------
36
Fugue
47.65
15%
4
- C5 -
-
5J5L
1
?
A:
[1-152]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
A
A
T
I
L
S
D
L
S
T
I
K
T
D
I
N
T
L
T
------
Q
H
F
N
E
F
T
G
D
--
L
L
Q
A
L
A
A
Q
A
V
-
E
Q
Q
L
E
-
S
D
I
D
Q
A
T
A
D
A
K
A
T
S
A
L
S
--
A
A
D
S
T
S
V
T
N
A
--
L
L
G
L
K
P
D
I
V
T
S
L
D
A
I
V
A
K
K
--
P
Q
V
D
S
A
G
---
V
-
G
S
L
V
L
S
D
-------
L
N
A
L
Q
S
K
T
D
A
L
S
G
A
-
L
Q
D
I
A
-
T
------------
A
T
D
K
-----
D
T
I
A
S
G
T
Q
-------------------
D
I
-
D
A
A
F
S
S
A
I
A
V
F
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
46.84
10%
52
* C5 *
-
3PDY
2
PLEC_HUMAN
A:
[7-208]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
S
T
--
L
R
Y
L
Q
D
L
L
A
W
-
V
E
E
N
Q
-
H
R
V
D
G
A
E
W
G
V
D
-
L
P
S
V
E
A
Q
L
G
S
H
R
G
L
H
Q
S
--
I
E
E
F
R
A
K
I
E
R
A
R
S
-
D
E
G
Q
L
SP
A
T
R
G
A
Y
R
---
D
C
L
G
R
L
D
L
Q
-------
Y
A
K
L
L
N
S
S
K
A
R
L
R
S
-
L
E
S
L
H
-
S
F
V
A
A
A
T
--
K
-
E
-
L
M
W
L
-----
N
E
K
E
E
E
E
V
-------------------
G
F
D
W
S
D
R
N
T
N
M
T
A
K
K
E
S
Y
--------
S
A
L
M
R
-------
E
L
E
L
K
E
K
K
I
K
E
L
Q
N
A
G
D
R
L
L
R
E
D
H
P
A
---
R
--
P
T
V
E
S
F
Q
A
A
L
Q
T
Q
W
S
W
M
L
Q
L
C
C
C
I
E
A
---
H
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
46.51
11%
-
- C5 -
-
3O4X
-
?
E:
[745-1198]
------------------------------------------------------------------------------------------------------------------
V
L
P
F
G
L
T
P
K
K
V
Y
K
P
E
V
Q
L
R
R
P
N
W
S
K
F
V
A
E
D
L
S
Q
D
C
F
W
T
K
V
K
E
D
R
F
E
N
N
E
L
F
A
K
L
T
L
A
F
S
A
Q
T
KV
K
E
L
K
V
LD
S
K
T
A
Q
N
L
S
I
F
L
G
S
F
R
M
P
Y
Q
E
I
K
N
V
I
L
E
V
N
EAVLT
E
S
M
I
Q
N
L
I
K
Q
MP
E
P
E
Q
L
K
M
L
S
E
-
L
K
E
E
Y
-
D
D
L
A
E
S
E
Q
F
G
V
V
M
G
T
V
P
R
L
R
P
R
L
N
A
I
L
F
K
L
Q
F
S
E
Q
V
E
N
I
K
P
E
I
V
-
S
V
T
A
A
--
C
E
E
L
R
K
S
---
E
N
F
S
S
L
L
E
L
-------
T
L
L
V
G
N
Y
M
N
A
G
S
R
N
-
A
G
A
F
G
-
F
N
I
S
F
L
C
--
K
-
L
-
R
D
T
K
SADQK
M
T
L
L
H
F
L
A
-------------------
E
L
-
C
E
N
D
H
P
E
V
L
K
F
P
D
E
L
--------
A
H
V
E
K
-------
A
S
R
V
S
A
E
N
L
Q
K
S
L
D
Q
M
K
K
Q
I
A
D
V
E
R
D
V
Q
N
F
--
P
A
A
T
D
E
K
D
K
F
V
E
K
M
T
S
F
V
K
D
A
Q
E
Q
Y
N
---
K
L
R
M
M
H
S
-
N
M
E
-
T
L
Y
K
E
L
G
D
Y
FVFDPKK
L
S
---
V
E
E
F
F
M
D
L
H
N
F
R
N
M
F
L
Q
A
V
K
E
--
N
Q
K
R
R
E
T
E
E
K
M
R
R
A
K
L
A
K
--
E
K
-
A
E
K
E
R
L
E
K
Q
Q
K
R
E
Q
-
L
I
D
M
N
A
E
G
D
E
T
G
V
M
D
S
L
L
E
A
L
Q
S
G
A
A
F
R
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
46.23
15%
-177
- C3 -
-
5DO7
-
ABCG8_HUMAN
D:
[486-671]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
L
Y
T
T
-
G
P
Y
F
F
A
K
I
L
G
E
L
-
P
E
H
C
A
Y
I
I
I
Y
G
M
P
T
Y
W
L
A
N
L
R
P
GL
Q
-
P
F
L
L
H
F
L
L
V
W
L
V
V
F
C
C
R
I
M
A
L
A
A
A
A
L
L
P
T
F
H
M
A
S
F
F
S
N
A
L
Y
N
--
S
F
Y
L
A
-
G
G
-
F
M
I
N
L
S
S
L
W
T
V
P
A
W
I
S
K
-
V
S
F
L
R
W
C
F
E
G
L
M
-------
K
I
Q
F
S
R
R
T
Y
K
M
P
L
GNL
T
I
A
V
S
GD
K
I
L
S
V
M
ELD
S
Y
---------------------------------
P
L
Y
A
I
Y
L
I
V
I
G
L
S
G
G
F
M
V
L
Y
Y
V
S
L
R
F
I
K
Q
K
P
--------------
8
PsiBlast_PDB
45.62
21%
75
- C3 -
-
4ZKT
-
?
A:
[427-763]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
I
N
N
G
E
L
---------
F
F
V
A
S
E
N
S
Y
N
-
D
D
N
I
N
T
P
K
E
I
D
D
-----
N
------
N
Y
E
N
D
L
D
-----
Q
V
I
L
N
F
N
---
A
P
G
L
S
D
E
K
L
N
L
T
I
Q
N
D
A
Y
I
P
K
Y
D
S
N
G
T
S
D
I
E
Q
H
D
---
V
N
E
L
--
N
V
F
F
Y
L
D
-
A
Q
-
K
V
--
P
E
G
E
N
N
V
---
N
L
T
S
S
I
D
T
A
L
L
E
Q
P
K
I
Y
T
F
F
S
S
E
F
I
N
N
V
N
K
-
P
V
Q
A
A
-
L
F
V
S
W
I
Q
--
Q
-
V
-
L
V
D
F
-----
T
T
E
A
N
Q
K
S
T
V
D
KIADISIVVPYIGLAL
N
I
-
G
N
E
A
Q
K
G
--
N
F
K
D
A
L
--------
E
L
L
G
A
-------
G
I
L
L
E
F
E
P
E
L
L
I
P
T
I
---
L
V
F
T
I
K
S
F
L
G
S
-----
S
D
N
K
N
K
V
I
K
A
I
N
N
A
L
K
E
R
D
E
K
W
K
E
---
V
Y
S
F
I
V
S
N
W
M
T
-
K
I
N
T
Q
F
N
K
--------
R
K
E
Q
M
Y
Q
A
L
Q
N
Q
V
N
A
I
K
T
I
I
E
S
K
Y
N
S
YT
L
E
E
K
N
E
L
T
N
K
Y
D
I
K
Q
I
E
N
E
L
N
Q
K
V
S
I
A
M
N
N
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
44.57
9%
-126
- C3 -
-
5XJY
-
?
A:
[654-1118]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
V
M
S
R
S
M
P
L
F
M
T
L
A
W
I
Y
S
V
A
V
I
I
K
G
I
V
Y
E
K
E
A
R
L
K
E
T
M
R
I
M
G
L
-
D
N
-
S
I
L
W
F
S
W
F
I
S
S
--
L
I
P
L
L
V
S
A
G
L
L
V
V
I
L
K
L
G
N
L
L
P
--
Y
S
D
P
S
V
V
F
V
F
L
S
V
F
A
V
V
T
I
L
Q
C
F
L
I
S
T
L
F
S
R
A
N
L
A
A
A
C
G
G
I
--
I
Y
F
T
L
Y
L
P
-
Y
V
L
C
V
A
W
Q
D
Y
V
G
F
T
L
K
I
F
A
S
L
L
S
P
V
A
F
G
F
G
C
E
Y
F
A
L
F
EEQ---------------------------------------------------------------------
G
F
N
L
T
T
S
V
S
M
M
L
F
D
T
F
L
Y
G
V
M
T
W
Y
I
E
A
V
---------------
35
Fugue
41.42
9%
39
- C5 -
-
3R6N
2
DESP_HUMAN
A:
[1-450]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
W
D
E
F
T
K
H
V
-
T
S
E
C
L
-
G
W
M
R
Q
Q
R
A
E
M
----
D
M
V
A
W
G
V
D
L
A
S
V
E
Q
H
--
I
N
S
H
R
G
I
H
N
S
I
G
D
-
Y
R
W
Q
L
--
D
K
I
K
A
D
L
REK
S
A
I
Y
Q
L
E
E
E
-------
Y
E
N
L
L
K
A
S
F
E
R
M
D
H
-
L
R
Q
L
Q
-
N
I
I
Q
A
T
S
--
R
-
E
-
I
M
W
I
-----
N
D
C
E
E
E
E
L
-------------------
L
Y
D
W
S
D
K
N
T
N
I
A
Q
K
Q
E
A
F
--------
S
I
R
M
S
-------
Q
L
E
V
K
E
K
E
L
N
K
L
K
Q
E
S
D
Q
L
V
L
N
Q
H
P
A
---
S
--
D
K
I
E
A
Y
M
D
T
L
Q
T
Q
W
S
W
I
L
Q
I
T
K
C
I
D
V
---
H
L
K
E
N
A
A
-
Y
F
Q
F
F
E
E
A
Q
S
T
E
--------
A
Y
---
L
K
G
L
Q
D
S
I
R
K
K
Y
P
C
D
K
N
M
P
L
Q
--
H
L
L
E
Q
I
K
E
L
E
K
E
R
E
K
I
L
E
Y
K
R
Q
-
V
Q
N
L
V
N
K
S
K
K
I
V
Q
L
-
K
P
R
N
P
D
Y
R
S
N
K
P
I
I
L
R
A
L
C
D
Y
K
Q
D
Q
K
I
V
H
K
G
D
E
C
I
L
K
D
N
--
N
E
R
S
K
W
Y
V
T
G
PGG
V
D
M
L
V
P
S
V
G
L
I
I
P
P
P
N
P
L
A
V
D
L
S
C
K
I
E
Q
Y
Y
E
A
I
L
A
L
W
N
Q
L
Y
I
N
M
K
S
L
V
-
S
W
H
Y
C
M
I
D
I
E
K
I
R
A
M
T
I
A
K
L
K
T
M
R
Q
E
D
Y
M
K
T
I
A
D
L
E
L
H
--
Y
Q
E
F
I
R
N
S
Q
G
S
E
M
F
G
D
D
D
K
R
K
I
Q
S
Q
F
T
D
A
Q
K
H
Y
Q
T
L
V
I
Q
L
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
40.47
24%
17
- C4 -
-
2ZCN
-
ICAR_STAEQ
A:
[49-129]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
S
V
E
N
C
F
N
Y
F
I
D
F
L
L
R
--
D
DNY
S
I
D
G
L
Y
Q
-
F
L
F
-
K
F
I
F
D
V
D
E
--------
R
Y
---
I
K
L
Y
V
Q
L
S
S
A
P
E
A
L
N
S
E
I
K
H
H
--
L
Q
E
I
N
T
T
L
H
D
E
L
I
K
Y
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
39.96
21%
19
- C3 -
-
2Z90
-
?
A:
[25-150]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
V
D
-
L
I
E
L
----
S
L
Q
G
K
Q
---
A
H
W
N
V
V
G
S
N
-------
F
R
D
L
H
L
Q
L
D
E
L
V
D
F
-
A
R
E
G
S
D
T
I
A
E
R
M
R
A
L
D
-
A
-
V
P
D
G
-----
R
S
D
T
V
A
A
T
-------------------
T
T
-
L
P
E
F
P
A
F
E
R
S
T
A
D
V
V
--------
D
L
I
T
T
-------
R
I
N
A
T
--------------
V
D
T
I
R
R
-
V
H
D
A
----
V
D
A
E
D
P
S
T
A
D
L
L
H
G
L
I
D
G
L
E
K
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
39.89
25%
-33
- C3 -
-
1WA5
1
CSE1_YEAST
C:
[825-948]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
N
L
L
D
R
-
K
I
A
L
I
G
V
L
N
M
V
I
N
G
Q
F
F
Q
S
K
Y
P
T
L
I
S
S
T
M
N
S
I
I
E
T
A
S
S
Q
S
I
A
N
L
K
N
D
Y
V
-----E
E
I
S
T
F
G
S
H
F
S
K
----------
L
V
S
I
S
E
K
P
F
D
P
L
P
E
I
-----
D
V
N
N
G
V
R
L
Y
V
A
E
A
L
N
K
Y
N
A
I
--
S
G
N
T
F
L
N
T
I
L
P
Q
L
T
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------