@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TYM0: (2017-12-15 )
MEEKKMKRFVRMGIDVGGTHTKAVAIDNATHEIIGKSSVKTTHDDVRGVAAGVVQSFQNCLRENNISPEDVVFVAHSTTQATNALIEGDVAKVGVIGMAKGGLEGFLAKRQTRLNDIDLGNKKKIEIVNAFLPVKHLNVDRVSETISSLERERAEVLVSSMAFGVDNGEPERVVYEAASVKSIPTTMASDITKLYGLTRRTRTAAINASILPKMLDTATSTEDSVREAGVNVSLMIMRGDGGVMEINEMKKRPVLTMLSGPAASVMGSLMYLRASNGVYFEVGGTTTNIGVIKNGRPAIDYSIVGGHPTYISSLDVRVLGVAGGSMVRANQSGIIDVGPRSAHIAGLDYAVFTETEKIKGPKVEFFSPKEGDPADYVKVVMEDGEEVTITNTCAANVLGLVQEEHFSYGNVPSARKAIQALADYCHTTVEDIAEQIMEKSYAKIEPVILELADKYHLEKDQISLVGVGGGAASLITYFSNKMGVKYSIPENAEVISSIGVALAMVRDVVERIIPSPSKEDIRSLKNEAMNKAIESGATPESIEVHVEIDPQTSKVTAIATGSTEVKATDLTKEITTEEALELAAEDMRLNKNEVCLLENTPFFYVCGEQNRSKNAGSLRIIDQKGFIKVQRGHASCMKTTAANYMTAVEQLWEDMAVYQTELIARPEFYLCLGARVSDFTATDLEQLQLLMDLEVSTMEPEEEVIVVAGNIKQT
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.......---.20---......-------...30........-------.------40.-.--------------------.---------.....50--------.........60.....----...-.70........80.-------....---...90.....-------...100..------------------------.....110.---------...-------...--120..-.....130-..--------------------......--------------------------140.....---.-.150---......--------..160.-...-...-170.......180-----.-------.......190.----------......200.......210.......220....----------...230.-......-240---.........250.......260.....--------..270----..---..---.....280-.......290--------...-------....--300----------..----------.......310......---.320------------.--..----....-330..-.---------..-----------...340.....-------------..350..-.....360.......370.--......380.......390.......-----400........----410----......-----------.420....--------....430.------....-..-440-..-.....450......-.-460..---.......470-........480-.....-....490......--.500---..-......510...----..---------------..520.......530....--...540.......550--.---...-..-------...560.-......570-----....--...-..580.--------..---....590..------------.....600....-----...610.......620------.......630.....--..640.....----..650.......660......--------.670.----------......680.......690.....-------..---.700....-...---710..----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
E
E
K
K
M
K
R
F
V
R
MGIDVGG---T
H
----
T
K
A
V
A
I-------DN
A
T
-
H
E
I
IGKSS-------V------KT
T
-
H
--------------------
D
---------
D
V
R
G
V
A
---------
A
G
V
V
Q
S
F
Q
N
C
-
L
R
ENN----I
S
P
-
E
D
V
V
F
V
AHSTTQA
T
-------
N
A
L
I---EGDVA
K
V
G
V
I
-------
G
MAKG
G
L
E
------------------------
G
F
L
A
K
R
Q
TR---------LND-------IDL--GN
K
K
K
-
I
E
I
V
N
A
F--LP--------------------VKHL
N
V
--------------------------
D
R
V
S
E
T
I
S
---
S
-
L
E
R
----
E
R
A
E
V
L
--------
V
S
S
M
AF-GVD-NGE-P
E
R
V
V
Y
EAASVK------S-------I
P
T
T
M
A
S
D
I
T
K
----------
L
Y
G
LTRR
T
R
T
AAI
N
A
S
I
L
P
K
M
L
DTATS
T
E
D
S
V
R
----------EAGV
N
V
S
-
L
M
I
M
RG-D-----G
G
V
M
E
I
N
E
MKKR
P
V
L
T
MLSG
P
A
A
S
V
M
G
--------
S
L
M
------
Y
L
---RA---SN
G
V
Y
F
E
V-GG
T
T
T
N
I
G
V
I--------KNG-------RP
A
I
--
D
------------
Y
S
----------IVGGHP
T
Y
I
S
SL
D
V
R
V
---
L
G
VA------------G--G
S
----
M
V
RA-N-QS
G
-
I
---------
I
D-----------VGPRSAHIAG
L
-------------
D
Y
A
V
F
TE-TEKIKGPK
V
E
F
FSPKEG
D
P
--
A
D
Y
V
K
V
V
M
EDG
E
E
V
T
I
T
N
T
C
A
A
N
V
L
G
-----
L
-
V
Q
E
E
HFSYG----NV
P
----
S
A
R
K
A
I
-----------
Q
A
-
L
A
D
Y
C
--------
H
T
T
V
E
D
I
A
------
E
Q
I
M
-
E
K
-
S
YA-K
I
-
E
P
V
I
L
E
L
A
D
K
YHLE-K-D--
Q
I
---
S
L
V
GVGG
G
A
--
A
S
L
I
T
Y
F
SN---KM
G
V
K
-
Y
SIPE
N
A
E
V
I
S
S
I
--
G
V
A
----
L
A
-
M
V
R
D
V
V
E
R
IIPS----P
S
---------------
K
E
D
I
R
S
L
K
N
E
A
M
N
K
A
I
ESG--ATP
E
S
I
E
V
H
V
E
IDP----Q---T
S
K
-
V
T
-------
A
I
ATGS
T
-
E
V
K
AT
D
L
-------
T
K
EI--
T
T
E
-
E
A
L
E
L
A
--------
A
E
---
D
MRLNKN
E
V
------------
C
L
LENT
P
F
F
Y
V
C-----GEQNRSKNAG
S
L
R
I
I
D------QK
G
F
I
K
V
QRG
H
A
S
C
M
--
K
T
T
A
A
N
Y
M
T
A
----
V
E
Q
L
W
E
D
M
A
V
Y
Q
T
E
LIARP
E
F
--------
Y
L
C
LG----------ARVSDFTAT
D
L
E
Q
L
Q
L
L
M
-DLEVS-------TM---EPEE
E
V
I
V
-VAG---NIKQT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
77.97
21%
10
- C4 -
-
5L9W
2
APCC_AROAE
B:
[8-718]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
I
N
S
I
D
I
D
V
G
G
---
T
F
----
T
D
F
V
L
T
-------
L
D
G
E
-
R
H
I
A
K
C
P
T
---------------
T
P
-
H
--------------------
D
---------
L
S
I
G
F
L
---------
N
A
V
E
A
G
G
D
K
V
G
L
S
V
E
E
----
L
L
P
-
R
-
I
D
I
I
R
Y
S
T
T
V
A
L
-------
N
R
L
L
---
Q
R
Q
G
P
R
I
G
L
L
-------
T
T
E
G
H
E
D
A
------------------------
I
L
I
G
R
G
A
Q
W
---------
T
D
G
-------
Q
R
V
--
A
E
R
R
N
-
I
A
V
Q
N
K
P
--
L
P
LIERDL
I
L
G
V
R
E
R
I
D
SSGSV
V
R
P
L
D
E
--------------------------
E
D
V
R
T
K
L
R
---
M
-
L
M
D
----
R
G
A
R
A
I
--------
V
V
S
L
L
W
-
S
F
M
-
N
P
A
-
H
E
K
R
V
R
E
I
I
R
E
E
------
Y
KEYHIG
F
V
P
V
V
M
S
H
S
V
V
S
----------
K
I
G
E
Y
E
R
T
M
T
A
V
L
D
A
Y
L
Q
R
S
M
Q
N
D
I
G
A
T
W
D
K
L
R
----------
A
K
G
Y
H
G
A
-
F
L
M
I
H
N
-
S
-----
G
G
S
A
D
I
F
K
T
P
A
S
R
--
T
F
N
G
G
P
V
A
G
L
M
G
--------
S
A
Y
------
F
A
---
N
K
L
GY
K
N
V
V
A
G
D
V
-
G
G
T
S
F
D
V
A
L
V
V
ESSVRN-
Y
T
F
-------
R
P
V
I
--
D
------------
K
W
----------
M
V
N
-----
V
T
M
M
Q
T
I
S
---
V
G
S
G
------------
G
--
G
S
----
I
A
K
V
-
D
-
R
S
G
-
T
R--------
L
E
-----------
V
G
P
R
S
A
G
---------------------------
S
M
P
G
P
--------------------
V
C
Y
D
L
G
G
T
E
P
T
V
T
D
A
D
V
V
L
G
-----
Y
-
I
N
P
D
T
Y
Y
G
G
----
R
M
P
L
N
K
A
K
A
E
K
A
I
-----------
R
E
K
I
A
Q
P
L
--------
G
I
E
T
I
E
A
A
------
A
L
I
R
-
Y
I
-
V
D
E
-
N
M
-
A
S
A
I
K
R
E
V
H
M
R
G
Y
H
-
P
-
E
--
D
F
---
V
L
F
A
F
G
G
A
G
--
P
T
H
M
A
G
L
K
G
---
D
I
P
K
A
-
V
V
F
P
A
-
A
P
V
F
C
A
M
--
G
S
S
I
M
D
I
V
H
-
M
Y
E
Q
S
R
R
M
V
F
M
E
----
P
G
TEKFVVD
Y
E
H
F
----
N
Q
T
V
D
T
M
I
E
R
A
R
Q
E
L
R
S
E
G
--
L
E
V
D
D
A
S
F
G
L
E
L
D
M
----
L
Y
GG
Q
V
N
-
L
K
-------
R
M
S
S
P
L
L
-
H
I
R
T
A
E
D
-------
A
L
K
V
--
Y
Q
A
-
F
E
T
E
F
S
--------
E
A
FS-
P
L
V
V
N
K
P
G
G
------------
V
F
L
D
N
F
V
L
R
V
T
V
-----
P
T
W
K
P
P
I
P
E
Y
P
L
Q
G
T
D
P-----
S
A
A
F
L
G
K
R
K
A
Y
W
P
E
T
--
K
----------------
H
W
A
D
T
P
T
Y
Q
F
E
L
L
Q
---------------
A
G
----------
N
V
I
D
G
P
A
I
V
E
A
E
L
T
T
I
V
V
P
P
R
Q
R
L
-------
S
I
---
D
T
H
G
L
A
I
L
-
E
A
I
---
D
P
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
70.73
21%
9
- C4 -
-
5L9W
2
APCC_AROAE
B:
[8-581]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
I
N
S
I
D
I
D
V
G
G
---
T
F
----
T
D
F
V
L
T
-------
L
D
---
G
E
-
R
H
I
A
K
-------
C
------
P
T
T
-
P
--------------------
H
---------
D
---
L
S
---------
I
G
F
L
N
A
V
E
A
G
-
G
D
K
V
G
LSVE
E
L
L
-
P
R
I
D
I
I
R
Y
S
T
T
V
A
L
-------
N
R
L
L
---
Q
R
Q
G
P
R
I
G
L
L
-------
T
T
E
G
-
H
E
D
------------------------
A
I
L
I
G
R
G
A
Q
WTDGQRVAE
R
R
N
IAVQNKP
L
P
L
--
I
E
R
D
L
I
L
G
V
R
E
R
I
D
S
S
G
SV------------------
V
R
P
L
D
E
--------------------------
E
D
V
R
T
K
L
R
---
M
-
L
M
D
----
R
G
A
R
A
I
--------
V
V
S
L
L
W
-
S
F
M
-
N
P
A
-
H
E
K
R
V
R
E
I
I
R
E
E
YKEYHI
G
F
------
V
P
V
V
M
S
H
S
V
V
S
----------
K
I
G
E
Y
E
R
T
M
T
A
V
L
D
A
Y
L
Q
R
S
M
Q
N
D
I
G
A
T
W
D
K
L
R
----------
A
K
G
Y
H
G
A
-
F
L
M
I
H
N
-
S
-----
G
G
S
A
D
--
I
F
K
T
P
A
S
R
T
F
N
G
G
P
V
A
G
L
M
G
--------
S
A
Y
------
F
A
N
K
L
G
Y
---
K
N
V
V
A
G
D
V
-
G
G
T
S
F
D
V
A
L
V
--------
V
E
S
-------
S
V
R
N
YT
F
------------
R
P
----------
V
I
D
K
W
M
V
N
V
T
M
M
Q
T
I
S
---
V
G
S
G
------------
G
--
G
S
----
I
A
K
V
-
D
-
R
S
G
T
R
---------
L
E
-----------
V
G
P
R
S
A
G
----------------------
S
M
-
P
---------------
G
-
P
--
V
C
Y
----
D
L
G
G
T
--
E
P
T
V
T
D
A
D
V
V
L
G
-----
Y
-
I
N
P
D
T
Y
Y
G
G
R
M
P
L
N
K
A
----
K
A
E
K
A
I
R
----------
E
K
-
I
A
Q
P
L
--------
G
I
E
T
I
E
A
A
------
A
L
I
R
-
Y
I
-
V
D
E
-
N
M
-
A
S
A
I
K
R
E
V
H
M
R
G
Y
H
-
P
-
E
--
D
F
---
V
L
F
A
F
G
G
A
G
--
P
T
H
M
A
G
L
K
G
---
D
I
P
-
K
-
A
V
V
F
P
A
A
P
V
F
C
A
M
--
G
S
S
----
I
M
-
D
I
V
H
M
Y
E
Q
S
R
R
M
----
V
F
MEPGTEKFVVD
Y
E
H
F
N
Q
T
V
D
T
M
I
E
R
A
R
Q
E
L
R
S
E
G
--
L
E
V
D
D
A
S
F
G
L
E
L
D
M
L
Y
GG
Q
---
V
N
L
-
K
R
-------
M
S
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
55.44
15%
-7
- C2 -
-
1E7P
-
FRDA_WOLSU
A:
[1-655]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
---
R
A
----
A
V
A
T
Q
Q
-------
K
G
L
S
-
T
I
V
L
S
L
I
P
-------
V
------
K
R
S
-
H
-------------------------------
S
A
A
A
Q
---------
G
G
M
Q
A
S
L
G
N
S
-
K
M
S
D
G
--------
D
N
E
D
L
H
F
M
D
T
V
K
G
S
-------
D
W
G
C
---
D
Q
K
V
A
R
M
F
V
N
-------
T
A
P
K
A
I
R
E
--------------------------
L
A
A
W
G
V
P
---------
W
T
R
-------
I
H
K
--
G
D
R
M
A
-
I
---------------------------------------------------------------
I
N
A
Q
K
T
T
---
I
-
T
E
E
----
D
F
R
H
G
L
--------
I
H
S
R
D
F
-
G
---
G
T
K
-
K
W
R
T
C
Y
T
A
D
A
-------------------------------------------------
T
G
H
T
M
L
F
A
V
A
N
E
C
L
K
L
G
V
S
I
Q
----------
D
R
K
E
A
I
A
-
L
I
H
Q
D
G
-
K
-----
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
--------
G
Y
G
------
R
I
---
Y
K
---
N
T
T
N
A
V
V
C
-
E
G
T
G
T
A
I
A
L
E
--------
T
G
I
-------
A
Q
L
G
--
N
------------
M
E
----------
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
TEG
C
R
G
D
------------
G
--
G
I
----
L
R
D
V
-
D
G
H
R
F
-
M
---------
P
D
-----------
Y
E
P
E
K
K
E
L
A
S
R
-------------
D
V
V
S
R
R
M
-
I
E
H
I
R
K
G
K
-----
G
V
Q
S
P
Y
--
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
-----
L
R
-----
D
-
V
Q
E
I
C
E
Y
F
A
----
G
I
D
----
P
A
E
K
W
A
-----------
P
V
-
L
P
-
M
Q
--------
H
Y
S
M
G
G
I
R
------
T
D
Y
R
-
G
E
-
A
--------------------------
K
L
---
K
G
L
F
S
A
G
E
A
--
A
C
W
D
M
H
G
F
N
---
R
L
G
-
G
-
N
S
V
S
E
A
V
V
A
G
M
I
V
--
G
E
Y
----
F
A
-
E
H
C
A
N
T
Q
V
D
L
E
T
----
K
T
---------------
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
--
G
T
E
D
V
F
K
I
K
N
R
M
K
D
----
V
---
M
D
D
N
V
G
-------
I
F
R
D
G
P
H
-
L
E
K
A
V
K
E
-------
L
E
E
L
--
Y
K
K
S
K
N
V
G
I
K
--------
N
K
---
R
L
H
A
N
P
E
L
E
------------
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
------
Y
P
-----
K
R
D
D
I
N
W
L
--
N
R
T
L
A
S
W
P
N
P
EQTL
P
T
L
E
Y
E
A
L
D
V
N
E
M
E
I
A
P
G
Y
R
G
--------
Y
G
A
K
G
----------
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
-
Q
S
E
L
E
-------
A
A
GKD
R
H
A
I
Q
E
A
L
-
M
P
Y
---
E
L
P
A
K
YKARNERLGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
53.24
19%
-2
* C2 *
-
5UAO
1
?
A:
[21-539]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
D
D
D
P
G
A
I
R
T
V
G
V
I
G
G
G
---
T
A
----
G
Y
L
T
A
L
-------
A
L
K
A
K
R
P
W
L
D
V
A
L
-------
V
------
E
S
A
-
D
--------------------
I
---------
P
I
I
G
V
G
---------
E
A
T
V
S
Y
M
V
M
F
-
L
H
-
H
Y
----
L
G
I
-
D
P
A
E
F
Y
Q
H
V
R
P
--------------------
T
W
K
L
G
I
R
-------
F
E
W
G
S
R
P
E
------------------------
G
F
V
A
P
-----------------------
F
D
W
--
G
T
G
S
--
V
G
L
V
G
S
L
--
R
E
--------------------
T
G
--
N
V
--------------------------
N
E
A
T
L
Q
A
M
---
L
-
M
T
E
----
D
R
V
P
V
Y
--------
R
G
-------
E
-
G
G
H
-
V
S
L
M
K
Y
----------------------------
L
P
F
----------
A
Y
H
M
---------
D
N
A
R
L
V
R
Y
L
T
E
L
A
A
R
R
G
-
V
R
----------
H
V
D
A
T
V
A
-
E
V
R
L
D
G
-
P
-----
D
H
V
G
G
L
I
T
T
D
G
R
R
L
----------------------------------------
H
Y
D
F
Y
V
D
C
-
T
G
F
R
S
L
L
L
E
K
--------
A
L
G
-------
I
P
---------------------------------
F
E
S
Y
A
S
S
L
F
T
----------------------------------------------------------------------------------------
D
A
A
V
T
G
T
-
L
A
H
--
G
G
H
L
K
P
Y
----------------------
T
T
A
T
T
M
N
A
G
W
C
W
T
-----
I
-
P
T
P
E
S
D
H
L
G
----
Y
V
F
----
S
S
A
A
-------------------------------
I
D
P
D
D
A
------
A
A
E
M
-
A
R
-
R
F
P
-
G
V
T
R
E
A
L
V
R
F
R
S
G
R
H
R
E
-
A
-
W
--
R
G
---
N
V
M
A
V
G
N
S
---------------------
Y
A
F
V
E
P
L
E
-------
S
S
G
----
L
L
-
M
I
A
T
A
V
Q
I
L
V
S
L
----
L
P
---------------
S
S
R
R
D
P
L
P
S
D
A
A
N
Q
A
L
A
H
R
W
D
A
I
R
W
F
L
S
I
H
Y
R
F
N
G
----
R
---
L
D
-----------------------
T
P
F
-------
W
K
E
A
--
R
A
E
-
T
D
I
S
G
I
--------
E
P
---
L
L
R
L
F
A
A
G
A
------------
P
L
T
G
R
D
S
F
T
R
Y
L
-----
A
D
G
A
A
P
L
F
Y
G
-
L
E
G
V
D
------
T
--
L
L
L
G
Q
E
V
P
A
R
L
L
--
P
P
R
E
P
----------
P
E
Q
W
R
A
R
A
A
A
A
R
S
L
A
S
R
G
-----------
L
R
Q
S
----------
E
A
L
D
A
Y
A
A
D
P
C
L
N
A
E
L
L
S
-
D
---
S
-------
D
S
---
W
A
G
E
R
V
A
V
-
R
A
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
46.61
14%
-151
- C4 -
-
3KZB
1
?
A:
[376-450]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
Q
I
L
------
L
A
V
L
-
E
G
-
A
A
L
-
S
L
-
R
W
C
A
E
L
L
G
M
---
E
K
-
V
-
G
--
L
L
---
K
V
V
G
G
G
A
R
S
--
E
A
W
L
R
M
I
A
D
---
N
L
N
V
S
-
L
L
V
K
P
D
A
H
L
H
P
L
R
--
G
L
A
----
A
L
-
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
44.09
17%
11
* C5 *
-
5B7I
1
CAS3_PSEAB
A:
[4-1082]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEFMN
I
L
L
V
S
QCEK
R
A
L
S
E
T
R
R
I
L
D
Q
F
AERRGER
T
W
Q
T
P
I
T
Q
A
G
L
D
T
L
R
R
L
L
K
K
S
A
R
---
R
N
----
T
-
A
V
A
C
H
W
IRGRD
H
S
E
L
-
L
W
I
V
G
D
A
S
RFNAQGA
V
------
N
D
W
-
H
S
A
------------------
E
---------
D
I
R
L
L
T
V
M
A
A
L
F
HDI
G
K
A
S
Q
A
F
Q
A
K
-
L
R
-
N
R
----
G
K
P
M
A
D
A
Y
R
H
E
W
V
S
L
R
L
F
-------
E
A
F
V
GPG
S
S
D
E
D
W
L
R
R
L
A
DKRETG
D
A
W
L
S
Q
L
A
RDDRQSAPPGPFQKSRLP
P
L
A
Q
A
V
G
W
L
I
V
S
H
H
R
---------
L
P
N
-------
G
D
H
--
R
G
S
A
S
-
L
A
R
L
P
A
P
--
I
Q
--------------------
S
Q
W
C
G
A
RDADAKEKAACWQFPHGLPFAS
A
H
W
R
A
R
T
A
L
C
A
Q
---
S
M
L
E
R
PGLL
A
R
G
P
A
L
L
H
D
S
Y
V
M
H
V
S
R
L
I
L
M
L
A
D
-
H
H
Y
-
S
S
L
P
A
D
S
R
L
G
D
P
------
N
-------
F
P
L
H
A
N
T
D
R
D
S
GKLKQR
L
D
E
H
L
L
G
V
A
L
H
S
R
K
L
A
G
T
L
P
R
L
E
R
Q
L
P
R
L
A
R
H
K
G
F
T
R
RVEQPRF
R
W
Q
D
K
A
Y
D
C
A
M
A
C
R
E
Q
A
M
E
-----
H
G
F
F
G
L
N
L
A
S
T
G
C
G
K
T
L
A
N
G
R
I
L
Y
A
L
A
DPQR
G
A
R
F
S
I
A
L
GLRSL
T
L
---
Q
T
---
G
Q
A
Y
R
E
R
L
-
G
L
G
D
D
D
L
A
I
L
V
G
G
S
AQEL
L
A
E
-------
N
S
H
V
--
H
------------
F
A
G
TLEDGPLRE
W
L
G
G
N
S
A
G
N
R
L
L
Q
A
P
I
---
L
A
C
T
IDHLMPASESLR
G
--
G
H
Q
I
A
P
L
L
R
L
M
T
-
S
D
L
-
V
---------
L
D
EVDDFDIDD
L
P
A
L
S
R
L
V
H
W
A
G
L
F
G
S
R
V
L
L
S
S
ATLP
P
A
L
V
Q
G
L
-
F
E
A
Y
R
S
G
R
-
E
I
F
Q
R
H
R
G
A
P
GR
A
T
E
I
R
C
A
W
F
D
E
F
S
S
Q
S
S
A
H
G
A
V
T
S
F
S
E
A
H
A
T
F
-
V
A
Q
R
L
A
K
L
E
----
Q
L
P
----
P
R
R
Q
A
Q
-----------
L
C
-
T
V
H
A
A
--------
G
E
A
R
P
A
L
C
------
R
E
L
A
-
G
Q
M
N
T
W
M
A
-------
D
L
H
R
C
H
H
T
E
-
H
-
Q
G
R
R
I
---
S
F
G
L
L
R
L
A
N
--
I
E
P
L
I
E
L
A
Q
---
A
I
-
L
A
-
Q
G
A
P
E
G
L
H
V
H
L
C
V
Y
H
S
R
H
----
P
L
-
L
V
R
S
A
I
E
R
Q
L
D
E
L
L
K
R
S
D
---------------
D
D
A
A
A
L
F
A
R
P
T
L
A
K
A
L
Q
A
----
S
T
E
R
D
H
L
F
V
V
L
A
S
----
P
---
V
A
E
-
V
G
RDHDYD
W
A
I
V
E
P
S
S
M
R
-
S
I
I
Q
L
A
G
R
IRRH
R
S
G
F
--
S
G
E
-
A
N
L
Y
L
L
--------
S
R
---
N
I
R
S
L
E
G
Q
N
PAFQRPGFETPD
F
P
L
D
S
H
D
L
H
D
L
L
-----
D
P
A
L
L
A
R
I
D
A
S
P
R
I
V
E
PFPLFP
R
S
R
L
V
D
L
E
H
R
R
L
R
A
L
ML
A
D
D
P
P
S
S
L
L
G
----
V
P
L
W
W
Q
T
P
A
S
L
S
G
A
L
Q
T
S
Q
P
F
RAGA
K
E
R
C
Y
A
L
L
P
DEDDEERLHF
S
R
Y
E
E
G
T
W
S
N
Q
D
N
L
L
R
N
L
-
D
L
T
Y
G
P
R
I
Q
T
W
G
T
V
---
N
Y
R
E
E
L
V
A
M
A
G
R
E
DL
D
L
R
Q
C
A
M
R
YG
E
V
R
L
R
ENTQ
G
W
S
Y
H
PYLGFKKYN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
43.12
14%
13
- C4 -
-
3CET
-
?
A:
[2-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
-
G
I
D
I
G
N
T
-
K
I
T
E
L
H
E
N
G
E
F
K
------
V
-------
H
H
L
V
S
H
V
A
L
V
T
----------
T
A
--
E
T
K
K
E
G
V
D
N
I
L
N
A
A
E
S
A
F
G
S
-------------------------
N
-
I
S
V
F
D
S
-
N
-----
G
N
F
I
S
L
E
S
A
K
T
N
N
M
--
K
V
S
A
S
N
W
C
G
T
A
--------
K
W
V
------
S
K
---
N
I
---
E
E
N
C
I
L
V
D
M
G
S
T
T
T
D
I
I
P
I
--------
V
E
G
-------
K
V
V
--------------------------------------------------
A
------------
E
--
K
T
----
D
L
E
R
-
L
M
N
H
E
-
L
---------
L
Y
-----------
V
G
T
L
R
T
P
I
S
H
L
-------------
G
N
T
I
S
F
------
K
G
V
D
T
N
V
S
S
E
Y
F
A
I
T
--
A
D
I
S
V
V
L
E
K
V
T
T
E
E
Y
T
C
D
T
--------------------
P
D
G
----
K
G
T
----
D
K
R
S
S
L
-----------
V
R
-
I
S
K
V
L
CSDLDQIS
E
I
D
A
E
N
I
A
------
K
N
Y
Y
-
E
L
-
W
K
E
-
L
I
-
L
E
N
V
E
N
V
A
E
K
Y
G
S
K
-----------
K
V
V
I
T
G
L
G
---
E
N
I
L
K
D
A
L
A
---
D
F
E
V
I
-
S
V
A
E
R
Y
G
K
D
V
S
L
A
--
T
P
S
----
F
A
-
V
A
E
L
L
K
N
E
L
L
E
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
40.91
18%
-88
* C4 *
-
3WXL
1
?
A:
[389-464]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
A
H
V
I
------
R
A
A
L
-
Q
A
-
I
A
L
-
Q
L
-
N
D
V
V
G
S
M
K
R
D
A
G
L
N
-
L
-
S
--
S
L
-----
R
V
D
G
G
L
S
KN
G
L
L
M
E
I
Q
A
S
---
L
L
G
V
D
-
I
L
V
P
S
M
H
E
-
T
T
A
L
--
G
A
A
----
L
C
-
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
39.74
16%
11
- C5 -
-
3QMZ
-
DYHC_YEAST
A:
[1364-4092]
E
F
V
I
E
K
S
L
N
R
I
K
K
F
W
K
E
A
QE
H
S
S
G
LK
L
V
R
E
WD
V
L
E
Q
A
C
K
E
D
L
E
E
L
V
S
M
K
A
SNYYK
I
F
E
Q
D
C
L
D
L
E
S
K
L
T
K
L
S
E
I
Q
V
N
W
V
E
V
Q
F
Y
W
L
D
L
Y
G
I
L
G
E
N
L
D
I
Q
NFLPLETSKFK
S
L
T
S
E
Y
K
M
I
T
T
R
A
F
Q
L
DTTIEVIH
I
P
N
F
D
T
T
L
K
L
T
I
D
S
L
K
M
I
K
S
S
L
S
T
F
L
E
R
Q
R
RD
D
L
L
K
I
I
GSG
K
H
H
D
Q
V
S
K
F
M
K
K
M
F
G
SDFITGVRSVEA
Q
E
W
L
N
I
L
D
T
E
I
K
L
S
V
F
T
Q
F
R
D
C
L
G
Q
L
K
D
GTDI
E
V
V
V
S
K
Y
IFQ
A
I
L
L
S
A
Q
V
M
W
T
E
L
V
E
K
CK
Y
W
K
E
V
D
M
K
I
K
G
L
L
D
K
L
N
KSD
N
V
K
K
K
I
E
A
L
L
V
E
Y
L
H
F
N
N
V
I
G
QR
L
L
W
A
K
V
Q
K
F
Y
L
N
S
V
F
I
S
Q
---
S
G
Y
L
LL
I
G
F
A
T
L
-------
T
D
S
L
-
H
Q
K
Y
G
G
C
F
-------
F
G
P
AGTG
K
T
E
-
T
--------------------
V
---------
K
A
F
G
Q
N
---------
L
G
R
V
V
V
V
F
N
C
-
D
D
S
F
D
----
Y
Q
V
-
L
S
R
L
L
V
G
I
T
Q
I
G
A
W
-------
G
C
F
D
---
E
F
N
R
L
D
E
K
V
L
-------
S
A
V
S
A
N
I
Q
------------------------
Q
I
Q
N
G
L
Q
V
G
---------
K
S
H
-------
I
T
L
LE
E
E
T
P
L
-
S
P
H
T
A
V
F
--
I
T
--------------------
L
L
P
E
N
L
--------------------------
K
K
S
F
R
E
F
S
M
K
-
S
-
Q
S
G
----
T
I
A
E
M
I
--------
L
Q
I
M
G
F
-
E
D
S
-
K
S
L
-
A
S
K
I
V
H
F
L
E
L
L
S
------
S
-------
K
C
S
S
M
N
H
---------------
Y
H
F
G
L
R
T
L
K
G
V
L
R
N
--
C
S
P
L
I
S
E
F
G
E
G
E
K
T
V
V
----------
E
S
L
K
R
V
I
-
L
P
S
L
G
D
-
T
-----
D
E
L
V
F
K
D
E
L
S
K
S
K
A
I
V
Q
C
L
K
D
A
G
E
-------------
E
------
F
L
---
K
K
---
C
M
Q
F
Y
Y
M
Q
-
K
T
Q
Q
A
L
I
L
V
G
--------
K
A
G
CGKT
A
T
W
K
T
V
I
--
D
A
-----------
M
A
----------
I
F
D
G
H
A
N
V
V
Y
V
I
D
T
K
V
---
L
T
K
E
------------
S
LY
G
S
----
M
L
K
A
-
T
----------------------------
L
E
W
R
D
G
L
F
T
S
I
-------------
L
R
R
V
N
D
D
I
T
G
T
F
K
N
S
R
I
W
V
V
F
D
S
D
L
D
P
--
E
Y
-----
V
E
A
M
N
S
V
L
D
D
N
K
G
E
R
L
P
I
P
-----
P
-
N
F
R
I
L
F
E
T
D
----
N
L
D
----
H
T
T
P
A
-------------
T
-
I
T
R
C
G
--------
L
L
W
F
S
S
K
I
------
D
H
L
L
-
N
K
-
S
Y
E
-
A
L
-
D
----
N
K
L
S
M
F
E
L
D
-
K
-
L
--
K
----
D
L
I
S
D
S
F
D
M
--
A
S
L
T
N
I
F
T
C
---
S
N
--
V
-
R
T
F
N
K
L
E
T
A
V
Q
L
A
--
V
H
L
----
I
S
-
S
Y
R
Q
W
F
Q
N
L
D
D
K
----
S
L
---------------
K
D
V
I
T
L
L
I
K
R
S
L
L
Y
A
L
A
G
D
--
S
T
G
E
S
Q
R
A
F
I
Q
T
I
N
----
T
---
Y
F
G
-
H
D
-------
S
Q
E
L
S
D
D
-
K
L
S
F
S
S
F
-------
C
S
E
I
PS
V
S
L
-
E
A
H
E
V
M
R
P
D
I
V
I
P
T
I
D
---
T
I
K
H
E
K
I
F
Y
------------
D
L
L
N
S
K
R
G
I
I
L
C
-----
G
P
P
G
S
G
K
T
M
I
M
N
N
A
L
R
------
N
S
S
L
Y
D
V
V
G
I
N
F
S
----
K
D
T
T
T
E
H
I
L
S
----
A
L
H
R
H
T
N
Y
V
I
K
N
L
V
L
F
C
V
V
L
F
--------
L
R
Q
L
M
----------
E
K
Q
G
F
W
K
T
P
E
N
K
W
V
T
I
E
R
-
I
H
I
V
G
-------
A
C
---
N
P
P
T
D
-----
P
G
---
R
I
P
M
S
ERFTRHAAIYP
S
G
K
S
L
S
Q
I
Y
E
I
YYKAIFKLV
P
E
F
R
S
Y
T
E
P
F
A
R
A
S
V
H
L
Y
N
E
C
K
A
R
YSTGLQSHYL
F
S
P
R
E
L
T
R
L
V
R
G
V
Y
T
A
I
NTGPRQTL
R
S
L
I
R
L
W
A
Y
E
A
W
R
I
FAVK
E
K
N
S
F
E
Q
L
L
Y
E
T
V
DKYL
P
N
Q
D
LG
N
I
S
S
TNK
T
D
L
V
N
F
I
E
E
R
F
K
T
F
C
D
EEP
M
V
I
H
E
S
M
V
D
H
I
L
R
I
D
R
A
LK
Q
V
Q
G
H
M
M
L
IGA
S
R
T
G
K
T
I
L
T
R
F
V
A
WL
N
G
L
K
I
V
Q
PKIHRHSNL
S
D
F
D
M
I
L
K
K
A
I
S
D
C
SLKES
R
T
C
L
I
I
DESNIL
E
T
A
F
L
E
R
M
N
T
L
L
ANDLFQG
E
E
Y
D
K
L
L
N
N
L
R
N
K
T
RD
T
E
Q
E
L
Y
D
W
F
V
G
E
I
A
K
N
L
H
V
V
F
T
I
CDPTNN
K
S
S
A
M
I
S
S
P
A
L
FNR
C
I
I
N
W
MT
K
T
M
S
Q
V
A
N
N
M
V
D
V
V
PMEFTDFI
V
P
E
V
N
K
E
L
V
F
T
E
P
I
Q
T
I
RDP
G
Y
F
I
D
GLR
A
L
V
K
L
V
T
A
K
Y
Q
D
L
Q
E
N
Q
R
F
V
N
V
G
L
E
K
L
N
E
S
VL
E
A
S
I
S
L
V
K
S
L
T
F
E
K
E
R
W
L
N
T
T
K
Q
F
S
K
T
S
Q
E
L
I
G
N
C
I
I
S
S
I
Y
E
T
Y
FGHLN
E
R
E
R
G
D
M
L
V
I
L
K
R
LLGKFAVKYDVNYRFIDYLV
T
L
D
E
K
M
K
WLECGY
F
L
E
N
M
S
I
V
M
N
S
QVPFLLDPS
S
H
M
I
T
V
I
S
NYYGNK
T
V
L
L
S
F
LEEG
F
V
K
R
L
E
N
A
V
R
FG
S
V
V
I
I
Q
D
G
E
F
F
D
P
I
I
S
R
L
I
S
R
E
FN
R
V
T
V
EI
G
D
H
E
VK
L
F
I
H
S
C
DPS
G
D
I
P
I
F
L
R
S
R
V
R
L
V
H
FVTS
I
E
T
R
I
F
D
I
T
L
T
E
E
N
A
E
M
Q
R
K
R
E
D
L
I
K
L
N
T
E
Y
R
L
K
L
K
N
L
E
K
R
L
L
E
E
L
N
ND
E
L
M
V
T
L
N
N
L
K
K
E
A
M
N
I
E
K
K
L
S
E
S
E
E
F
F
PQ
F
D
N
L
V
E
E
Y
S
I
I
G
K
H
S
V
K
I
F
S
M
L
E
K
F
G
QFHWFYGIS
I
G
Q
F
L
S
C
F
K
R
V
F
I
KTRA
A
R
T
R
V
D
E
I
L
W
L
L
Y
Q
EVYCQFST
A
L
D
K
K
F
K
M
I
M
AM
T
M
F
C
L
Y
K
F
D
IESEQLTVD
T
N
D
D
L
R
Y
L
W
D
Y
V
TTK
S
Y
I
S
A
L
N
W
FKNW
N
I
A
D
V
V
A
N
SE
N
N
Y
F
T
M
A
S
EDG
T
F
K
L
I
E
L
A
K
A
SKES
L
K
I
I
PLGSIEN
L
N
Y
A
Q
E
E
I
S
K
S
K
I
E
G
G
W
I
L
L
Q
NIQMSL
S
W
V
K
T
Y
L
H
K
H
V
E
ETKAAEEK
M
F
M
T
C
HLTG
D
K
L
P
APLLQRTD
R
V
V
Y
E
D
I
PGI
L
D
T
V
K
D
L
W
G
S
Q
F
FTGSGV
W
S
V
Y
C
T
F
L
L
S
W
F
H
A
L
I
T
A
RD
C
D
F
Q
F
A
S
V
Y
L
E
N
V
L
APWAQ
V
R
D
H
I
A
T
I
VYGGKIDEEK
D
L
E
V
V
A
K
L
C
A
H
VFCD
N
L
Q
I
V
P
G
V
RIPQPLLQQ
S
E
E
E
E
R
A
R
L
T
A
IADS
L
S
S
W
L
Q
LPRES
I
L
D
Y
E
R
L
Q
A
K
E
V
A
S
S
T
E
Q
L
L
Q
E
M
22
HHSearch
39.59
14%
32
- C4 -
-
3CET
-
?
B:
[24-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
--------
H
H
L
Y
F
P
-
M
W
K
-
N
N
D
K
L
A
E
V
L
K
T
Y
S
N
D
V
S-----
H
-------
V
A
L
V
T
T
A
E
L
A
D
----------
S
Y
E
T
K
K
E
G
------------
V
D
N
I
L
N
A
A
E
S
A
F
G
---------------
S
N
-
I
S
V
F
D
S
-
N
-----
G
N
F
I
S
L
E
S
A
K
T
N
N
M
K
V
S
A
S
N
W
C
G
T
A
K
W
--------
V
S
K
------
N
I
----
E
---
E
N
C
I
L
V
D
M
-
G
S
T
T
T
D
I
I
P
I
--------
V
E
G
-------
K
V
-
V
--
A
E
KT
D
L
E
R
L
M
N
HE
L
L
----------
Y
V
G
T
L
R
T
P
I
S
H
L
-
G
N
T
---
I
S
F
K
------------
G
--
V
D
----
T
N
V
S
-
S
-
E
Y
F
-
A
I
T
A
D
I
S
V
V
L
E
K
-----------
V
-
T
T
E
E
Y
-------------------------------------------
T
---
C
D
----
T
P
D
G
K
--
G
T
D
K
R
S
S
L
V
R
I
S
-----
K
V
L
C
S
----------
D
L
D
Q---
I
S
E
I
D
A
-------------------------------
E
N
I
A
------
K
N
Y
Y
-
E
L
-
W
K
E
-
L
I
-
L
E
N
V
E
N
V
A
E
K
--
Y
G
-
S
-
K
-------
K
V
V
I
T
G
L
G
E
---
N
I
L
K
D
A
L
A
DFE
V
I
S
V
A
E
R
Y
G
K
D
V
S
L
A
T
P
S
F
--
A
V
A
----
E
L
-
L
K
N
E
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
39.05
13%
-22
- C4 -
-
1HUX
2
HGDC_ACIFV
A:
[2-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
I
Y
T
L
G
I
D
V
-
G
S
T
A
S
K
C
I
I
L
--------
K
D
G
-------
K
E
I
V
--
A
------------
K
S
----------
L
V
A
V
G
T
G
T
S
G
P
A
R
S
I
S
---
E
V
L
E
------------
N
--
A
H
----
M
K
K
E
-
D
-
M
A
F
-
T
---------
L
A
-----------
T
G
Y
G
R
N
S
L
E
G
I
AD
K
Q
M
S
-------
E
L
S
C
H
A
M
-
G
A
S
F
I
W
P
N
V
H
T
V
I
D
I
G
G
Q
D
--
V
K
V
I
H
V
E
N
G
T
M
T
N
F
Q
M
N
D
K
C
A
A
G
T
G
R
-----
F
-
L
D
V
M
A
N
I
L
E
----
V
K
V
----
S
D
L
A
E
L
G
A
K
ST
K
R
V
A
IS
S
T
-
C
T
V
F
A
--------
E
S
E
V
I
S
Q
L
S
K
GTD
K
I
D
I
I
-
A
G
-
I
H
R
-
S
V
-
A
S
R
V
I
G
L
A
N
R
V
G
I
V
-
K
-
D
---
V
---
V
M
T
G
G
V
A
Q
N
--
Y
G
V
R
G
A
L
E
E
---
G
L
G
V
E
-
I
K
T
S
P
L
A
Q
Y
N
G
A
L
--
G
A
A
----
L
Y
-
A
Y
K
K
A
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
36.56
12%
33
- C1 -
-
5FRP
-
PDS5_YEAST
A:
[3-691]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
A
V
T
K
L
K
F
N
S
P
I
I
S
T
S
D
Q
L
I
S
T
----
N
E
L
L
D
R
-------
L
K
A
L
-
H
E
E
L
A
S
L
D
-------
Q
------
D
N
T
D
L
--------------------
T
---------
G
L
D
K
Y
R
---------
D
A
L
V
S
--
R
K
L
-
L
K
H
K
D
----
V
G
I
-
R
A
F
T
A
C
C
L
S
D
I
L
R
L
Y
APDAPY
T
D
A
Q
---
L
T
D
I
F
K
L
V
L
S
-------
Q
F
E
Q
L
G
D
Q
------------------------
E
N
G
Y
H
I
Q
Q
T
---------
Y
L
I
-------
T
K
L
--
L
E
Y
R
S
-
I
V
L
L
A
D
L
--
P
S
--------------------
S
N
N
L
L
I
--------------------------
E
L
F
H
I
F
Y
D
PN
K
S
-
F
P
A
----
R
L
F
N
V
I
--------
G
G
I
L
G
E
-
V
I
S
-
E
F
D
-
S
V
P
L
E
V
L
R
L
I
F
N
------
K
-------
F
L
T
Y
N
P
N
E
I
P
E
----------
G
L
N
V
T
S
-------
D
C
G
Y
E
V
S
L
I
L
C
D
T
Y
S
N
R
M
S
R
----------
H
L
T
K
Y
Y
S
-
E
I
I
H
E
A
-
T
N
DDNN
S
R
L
L
T
V
V
V
K
L
H
K
L
V
L
R
L
W
E
T
V
P
E
L
I
N
A
V
I
------
G
F
I
------
Y
H
---
E
L
---
S
S
E
N
E
L
F
R
-
K
E
A
T
K
L
I
G
Q
I
--------
L
T
S
-------
Y
S
----
D
------------
L
N
----------
F
V
S
T
H
S
D
T
F
K
A
W
I
S
K
I
---
A
D
I
S
------------
P
--
D
V
----
R
V
E
W
-
T
-
E
S
--
I
---------
P
Q
-----------
I
I
A
T
R
E
D
I
S
K
E
-------------
L
N
Q
A
L
A
K
-
T
F
I
D
S
D
P
R
V
R
R
T
S
V
M
I
F
N
K
--
V
P
V
T
E
I
W
K
N
I
T
-----
N
K
A
I
Y
T
S
L
L
H
-----
L
-
A
R
E
K
H
---------
K
E
----
V
R
E
L
C
I
-----------
N
T
-
M
A
K
F
Y
--------
S
N
S
L
N
E
I
E
------
R
T
Y
Q
N
K
E
-
I
W
E
-
I
I
-
D
T
I
P
S
T
L
Y
N
L
Y
Y
I
N
-
D
-
L
--
N
I
---
N
E
Q
V
D
S
V
I
F
--
E
Y
L
L
P
F
E
--------------
P
D
N
D
K
R
V
H
R
L
--
L
T
V
----
L
S
H
F
D
K
K
A
F
T
S
F
F
A
F
----
N
A
---------------
R
Q
I
K
I
S
F
A
I
S
K
Y
I
D
F
S
K
F
L
--
N
N
Q
E
S
M
S
-----
S
S
----
Q
---
G
P
I
-
V
M
-------
N
K
Y
N
Q
T
L
-
Q
W
L
A
S
G
L
-------
S
D
S
T
--
K
A
I
-
D
A
L
E
T
I
--------
K
Q
F
ND
E
R
I
F
Y
L
L
N
A
------------
C
V
T
N
D
I
P
F
L
T
F
-------
K
N
C
Y
N
E
L
V
S
K
L
Q
----------------------------
T
P
S
I
M
P
R
D
----
I
A
K
V
I
Q
I
L
L
F
R
A
S
P
I
I
Y
N
V
-----------
S
N
I
S
----------
V
L
L
N
L
S
N
N
S
D
A
K
Q
L
D
L
K
R
-
R
I
L
D
D
-------
I
S
---
K
V
N
P
T
L
F
K
-
D
Q
I
---
R
T
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
35.38
16%
-38
- C4 -
-
3L0Q
1
?
B:
[3-96]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
S
Y
F
I
G
V
D
V
G
T
---
G
S
----
A
R
A
G
V
F
-------
D
L
Q
--
G
R
M
V
G
Q
A
S
-------
R
------
E
I
T
-
M
F
K
PKAD
F
V
E
-----------
Q
---------
S
S
E
N
I
W
---------
Q
A
V
C
N
A
V
R
D
A
-
V
N
Q
A
D
----
I
N
P
-
I
Q
V
K
G
L
G
F
D
A
T
-
C
S
-------
L
V
V
L
---
D
K
E
G
N
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
35.20
16%
-45
- C4 -
-
3QDK
-
ARAB_BACHD
D:
[5-110]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
I
G
V
D
Y
G
T
---
E
S
----
G
R
A
V
L
I
-------
D
L
S
N
-
G
Q
E
L
A
D
H
V
-------
T
------
P
Y
R
-
H
GVIDQYLPNTNIKLGHE
W
A
L
Q
---------
H
P
L
D
Y
V
---------
E
V
L
T
T
S
V
P
A
V
-
M
K
E
S
G
----
V
D
A
-
D
D
V
I
G
I
G
V
D
F
T
A
C
T
-------
M
L
P
V
---
D
E
E
G
Q
P
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
34.40
18%
-40
- C4 -
-
3LL3
1
?
A:
[2-93]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
K
Y
I
I
G
M
D
V
G
T
---
T
A
----
T
K
G
V
L
Y
-------
D
I
N
--
G
K
A
V
A
S
V
S
-------
K
------
G
Y
P
-
L
--------------------
I
Q
TKVG
Q
A
E
E
D
P
K
L
I
F
---------
D
A
V
Q
E
I
I
F
D
L
-
T
Q
K
-------
I
D
-
G
K
I
A
A
I
S
W
S
S
Q
M
H
S
-------
L
I
G
L
---
G
S
D
D
E
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
34.28
18%
-42
- C4 -
-
3GBT
-
?
A:
[0-91]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
K
Y
I
I
G
M
D
V
G
T
---
T
A
----
T
K
G
V
L
Y
-------
D
I
N
--
G
K
A
V
A
S
V
S
-------
K
------
G
Y
P
-
L
--------------------
I
QTKVG
Q
A
E
E
D
P
K
L
I
F
---------
D
A
V
Q
E
I
I
F
D
L
-
T
Q
K
-------
I
D
-
G
K
I
A
A
I
S
W
S
S
Q
M
H
S
-------
L
I
G
L
---
G
S
D
D
E
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
33.58
18%
-18
- C4 -
-
2W40
-
?
B:
[376-452]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
S
H
I
V
------
R
A
L
L
-
E
G
-
I
A
F
-
Q
L
-
N
E
I
V
D
S
L
T
S
D
M
G
I
E
-
M
L
H
--
V
-----
L
R
C
D
G
G
M
T
KN
K
P
F
M
Q
F
N
S
D
---
I
I
N
T
K
-
I
E
V
S
K
Y
K
E
-
V
T
S
L
--
G
A
A
----
V
L
-
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
32.39
13%
-0
- C4 -
-
2ZF5
-
GLPK_THEKO
Y:
[1-93]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
F
V
L
S
L
D
E
G
T
---
T
S
----
A
R
A
I
I
F
-------
D
R
E
--
S
N
I
H
G
I
G
Q
-------
Y
------
E
F
P
-
Q
HYPRPGWVE-----------
H
---------
N
P
E
E
I
W
---------
D
A
Q
L
R
A
I
K
D
A
-
I
Q
S
A
R
----
I
E
P
-
N
Q
I
A
A
I
G
V
T
N
Q
R
E
T
-------
T
L
V
W
---
D
K
D
G
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
31.66
20%
-7
- C4 -
-
3H3N
4
GLPK_ENTCA
X:
[2-92]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
K
N
Y
V
M
A
I
D
Q
G
T
---
T
S
----
S
R
A
I
I
F
-------
D
R
N
--
G
K
K
I
G
S
S
Q
-------
K
------
E
F
P
-
Q
YFPKSGWVE-----------
H
---------
N
A
N
E
I
W
---------
N
S
V
Q
S
V
I
A
G
A
-
F
I
E
S
G
----
I
R
P
-
E
A
I
A
G
I
G
I
T
N
Q
R
E
T
-------
T
V
V
W
---
D
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
31.65
14%
-28
- C4 -
-
4CZG
1
?
A:
[255-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
G
-
Q
I
-
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
-
S
--
D
I
A
D
K
G
I
M
L
T
G
G
G
A
LL
R
G
L
D
A
E
I
R
D
---
H
T
G
L
P
-
V
T
V
A
D
D
P
L
S
C
V
A
L
--
G
C
G
----
K
V
-
L
E
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------