@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TYM6: (2017-12-15 )
MTIDWQKEVEARKEDLLEDLKNLLRVNSERDDSKVTPDAPFGPGPRDALKHMLAYGERDGFKVKNVDNYAGHIDLGEGDETLGIFGHMDVVPAGDGWDTDPYEPVIKDGKIFARGSSDDKGPSMAAYYAMKIIKELDLKLSKKVRFVVGSDEESGWGDMAYYFEHEEEPDFGFSPDAEFPIINGEKGNVSLALRFKGDNAGDYVLKSFVSGLRENMVPGTATAALQVPSADAAIAMEEAFYQFIEANPVSGTIEADNTYVKIELVGKGAHGASPQSGINAGSFLALFLDNYEFLGSAKQFIHVAAAYVHEDFYGEKLGVAYEDEKMGKLTMNAGLFAFEENGTEEANFINMNFRFPKGVTVDGLQSDIEQTVGQEGATVTRGARVMEPHYVPMDDPLVATLLQVYEDHTGEKGYEQIIGGGTYGRLLKRGVAYGAMFPGYTDTMHQANEFMSLDDLFRATAIYADAIYRLAK
Atome Classification :
(20 SA)
-.........10........20........30........40..-......50........60------.-....----------------------.-------------..------70..-..-.--.--..80........90..-------.--.---...----.100....-.--..110....----...120.......130.......140.......150...-----.-...160....---------.----...170.....-..----180----.........190.---.....-.200-........210.......220.......230.......240.......250.....-----..260......----.--.-.--270------...-.-...280.......290...-----------------.---..-----------------.300...----------..---..310-.--...------.-.----.--.--.---------320.......330......----.-------------340----.........350.......360.......370..-.----.--------.--------..380.--.---....-..390..-.....400.......410----..-..---.---..420--....-.-.-----.430.---........440.......450.......460.......470---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MTI
D
W
Q
K
E
V
E
A
R
K
E
D
L
L
E
D
L
K
N
L
L
R
VNSERDDSKVTPDAPFGP-
G
P
R
D
A
L
K
H
M
L
A
YGERDG
F
------
K
-VKNV----------------------D-------------NY------AG
H
I
-DL-G--E--GDE
T
L
G
I
FGHM
D
V
VPA-------G--D---GWD----TDPYEPVI-K--D
G
K
I
F
ARGS----SDDKG
P
S
M
A
A
Y
Y
A
M
K
I
I
K
E
L
D
L
K
L
S
K
K
V
R
F
V
VGSDEESG-----W-GD
M
A
Y
-
Y
F
EH---------E----EEPDFGFSPDA-EF----P------IINGEKG
N
V
S
L
A
L
---
R
F
KGD-NA-
G
-
D
Y
V
L
K
S
F
V
S
G
L
R
E
NMVPGT
A
T
A
A
L
QVPSA
D
A
A
I
A
M
E
E
A
F
Y
Q
F
I
EANPV
S
G
T
I
EADN-----
T
Y
V
--
K
I
E
L
V
G----K--G-A--HGA------SPQ-S-GINA
G
S
F
L
A
L
F
LD
N
Y
E
F
L
G
-----------------
S
---
A
K
-----------------
Q
F
I
H
V
A
A
----------
A
Y
---
V
H
E
---
D
--FYG------E-K----L--G--
V
---------
A
YEDEKM
G
K
L
T
MNA
G
L
F
A
F----E-------------E------NGTEEA
N
F
I
N
M
N
F
RFPKGV
T
V
D
G
L
Q
S
D
I
E
Q
T
VGQ-E----G--------
A
--------
T
VTR-G--
A
---
R
VME-PHYVPMD-D
P
L
V
A
T
L
L
Q
V
Y
E
DHTGE
K
----
G
Y
-
E
Q
---I---IGG
G
T
--
Y
G
R
L
-
L
-
K
-----
R
G--V---AYGAMFPGY
T
D
T
M
H
Q
A
N
E
F
M
S
L
D
D
L
F
R
A
T
A
I
Y
A
D
A
I
Y
R
LAK---
52
Fugue
94.64
45%
10
- C1 -
-
1LFW
-
PEPV_LACDL
A:
[1-468]
-
M
D
L
N
F
K
E
L
A
E
A
K
K
D
A
I
L
K
D
L
E
E
L
I
A
I
D
S
S
E
D
L
E
N
A
T
E
E
Y
P
V
G
K
-
G
P
V
D
A
M
T
K
F
L
S
F
A
K
R
D
G
F
------
D
-
T
E
N
F
----------------------
A
-------------
N
Y
------
A
G
R
V
-
N
F
-
G
--
A
--
G
D
K
R
L
G
I
I
G
H
M
D
V
V
P
A
-------
G
--
E
---
G
W
T
----
R
D
P
F
K
M
E
I
D
E
--
E
G
R
I
Y
G
R
G
S
----
A
D
D
K
G
P
S
L
T
A
Y
Y
G
M
L
L
L
K
E
A
G
F
K
P
K
K
K
I
D
F
V
L
G
T
N
E
E
T
N
-----
W
-
V
G
I
D
Y
-
Y
L
K
H
---------
E
----
P
T
P
D
I
V
F
S
P
D
A
-
E
Y
----
P
------
I
I
N
G
E
Q
G
I
F
T
L
E
F
---
S
F
K
N
D
-
D
T
K
G
-
D
Y
V
L
D
K
F
K
A
G
I
A
T
N
V
T
P
Q
V
T
R
A
T
I
S
G
P
D
---
L
E
A
V
K
L
A
Y
E
S
F
L
A
D
K
E
L
D
G
S
F
E
I
N
D
-----
E
S
A
--
D
I
V
L
I
G
----
Q
--
G
-
A
--
H
A
S
------
A
P
Q
-
V
-
G
K
N
S
A
T
F
L
A
L
F
L
D
Q
Y
A
F
A
G
-----------------
R
---
D
K
-----------------
N
F
L
H
F
L
A
----------
E
V
---
E
H
E
---
D
--
F
Y
G
------
K
-
K
----
L
--
G
--
I
---------
F
H
H
D
D
L
M
G
D
L
A
S
S
P
S
M
F
D
Y
----
E
-------------
H
------
A
G
K
---
A
S
L
L
N
N
V
R
Y
P
Q
G
T
D
P
D
T
M
I
K
Q
V
L
D
K
F
S
G
-
I
----
L
--------
D
--------
V
T
Y
N
-
G
--
F
---
E
--
E
-
P
H
Y
V
P
G
S
-
D
P
M
V
Q
T
L
L
K
V
Y
E
K
Q
T
G
K
P
----
G
H
-
E
V
---
V
---
I
G
G
G
T
--
Y
G
R
L
-
F
-
E
-----
R
G
--
V
---
A
F
G
A
Q
P
E
N
G
P
M
V
M
H
A
A
N
E
F
M
M
L
D
D
L
I
L
S
I
A
I
Y
A
E
A
I
Y
E
L
T
K
DE-
1
PsiBlast_PDB
94.39
45%
9
* C1 *
-
1LFW
-
PEPV_LACDL
A:
[1-466]
-
M
D
L
N
F
K
E
L
A
E
A
K
K
D
A
I
L
K
D
L
E
E
L
I
A
I
D
S
S
E
D
L
E
N
A
T
E
E
Y
P
V
G
K
-
G
P
V
D
A
M
T
K
F
L
S
F
A
K
R
D
G
F
------
D
-
T
E
N
F
----------------------
A
-------------
N
Y
------
A
G
R
V
-
N
F
-
G
--
A
--
G
D
K
R
L
G
I
I
G
H
M
D
V
V
P
A
-------
G
--
E
---
G
W
T
----
R
D
P
F
K
M
E
I
D
E
--
E
G
R
I
Y
G
R
G
S
----
A
D
D
K
G
P
S
L
T
A
Y
Y
G
M
L
L
L
K
E
A
G
F
K
P
K
K
K
I
D
F
V
L
G
T
N
E
E
T
N
-----
W
-
V
G
I
D
Y
-
Y
L
K
H
---------
E
----
P
T
P
D
I
V
F
S
P
D
A
-
E
Y
----
P
------
I
I
N
G
E
Q
G
I
F
T
L
E
F
---
S
F
K
N
D
-
D
T
K
G
-
D
Y
V
L
D
K
F
K
A
G
I
A
T
N
V
T
P
Q
V
T
R
A
T
I
S
G
P
D
L
E
---
A
V
K
L
A
Y
E
S
F
L
A
D
K
E
L
D
G
S
F
E
I
N
D
-----
E
S
A
--
D
I
V
L
I
G
----
Q
--
G
-
A
--
H
A
S
------
A
P
Q
-
V
-
G
K
N
S
A
T
F
L
A
L
F
L
D
Q
Y
A
F
A
G
-----------------
R
---
D
K
-----------------
N
F
L
H
F
L
A
----------
E
V
---
E
H
E
---
D
--
F
Y
G
------
K
-
K
----
L
--
G
--
I
---------
F
H
H
D
D
L
M
G
D
L
A
S
S
P
S
M
F
D
Y
----
E
-------------
H
------
A
G
--
K
A
S
L
L
N
-
N
V
R
Y
P
Q
G
T
D
P
D
T
M
---
I
K
Q
V
L
D
K
F
S
----
G
--------
I
--------
L
D
V
T
-
Y
--
N
---
G
F
E
E
-
P
H
Y
V
P
G
S
-
D
P
M
V
Q
T
L
L
K
V
Y
E
K
Q
T
G
K
P
----
G
H
-
E
V
---
V
---
I
G
G
G
T
--
Y
G
R
L
-
F
-
E
-----
R
G
--
V
---
A
F
G
A
Q
P
E
N
G
P
M
V
M
H
A
A
N
E
F
M
M
L
D
D
L
I
L
S
I
A
I
Y
A
E
A
I
Y
E
L
T
K
---
30
HHSearch
87.31
43%
32
- C1 -
-
1LFW
-
PEPV_LACDL
A:
[1-466]
-
M
D
L
N
F
K
E
L
A
E
A
K
K
D
A
I
L
K
D
L
E
E
L
I
A
I
D
S
S
E
D
L
E
N
A
T
E
E
Y
P
V
G
K
G
P
V
D
A
M
T
K
F
L
-
S
F
A
K
R
D
G
F
------
D
-
T
E
N
F
----------------------
A
-------------
N
Y
------
A
G
R
V
-
N
F
-
G
--
A
--
G
D
K
R
L
G
I
I
G
H
M
D
V
V
P
A
-------
G
--
E
---
G
W
T
----
R
D
P
F
K
M
E
I
-
D
E-
E
G
R
I
Y
G
R
G
S
----
A
D
D
K
G
P
S
L
T
A
Y
Y
G
M
L
L
L
K
E
A
G
F
K
P
K
K
K
I
D
F
V
L
G
T
N
E
E
T
N
-----
W
-
V
G
I
D
Y
-
Y
L
K
H
---------
E
----
P
T
P
D
I
V
F
S
P
D
A
-
E
Y
----
P
------
I
I
N
G
E
Q
G
I
F
T
L
E
F
---
S
F
K
N
D
-
D
T
-
K
G
D
Y
V
L
D
K
F
K
A
G
I
A
T
N
V
T
P
Q
V
T
R
A
T
I
S
G
P
D
L
E
A
---
V
K
L
A
Y
E
S
F
L
A
D
K
E
-----
L
D
G
S
F
E
I
ND
E
S
A
--
D
I
V
L
I
G
----
Q
--
G
-
A
--
H
A
S
------
A
P
Q
-
V
-
G
K
N
S
A
T
F
L
A
L
F
L
D
Q
Y
A
F
A
G
-----------------
R
---
D
K
-----------------
N
F
L
H
F
L
A
----------
E
V
---
E
-------------------------------------------
H
E
D
--
F
Y
G
K
K
L
G
I
F
H
H
----
D
DLM
G
D
L
A
S
S
P
S
M
F
D
------
Y
E
H
A
G
K
A
S
L
L
N
N
V
R
Y
P
Q
G
T
D
P
D
T
M
I
K
Q
V
L
D
K
F
S
G
------
I
--------
L
--------
D
V
T
--
Y
--
N
---
G
F
E
E
-
P
H
Y
V
P
G
S
-
D
P
M
V
Q
T
L
L
K
V
Y
E
K
Q
T
G
K
P
----
G
H
-
E
V
---
V
---
I
G
G
G
T
--
Y
G
R
L
-
F
-
E
-----
R
G
--
V
---
A
F
G
A
Q
P
E
N
G
P
M
V
M
H
A
A
N
E
F
M
M
L
D
D
L
I
L
S
I
A
I
Y
A
E
A
I
Y
E
L
T
K
---
33
HHSearch
65.49
22%
36
- C1 -
-
4PQA
1
DAPE_NEIMB
A:
[2-376]
------------
T
E
T
Q
S
L
E
L
A
K
E
L
I
S
R
P
S
V
T
P
D
-------------
D
R
D
C
Q
K
L
L
A
E
R
L
H
K
I
G
F
------
A
-
A
E
E
L
H
F
--------------------
G
-------------
D
T
------
K
N
I
W
L
R
R
-
G
--
T
--
K
A
P
V
V
C
F
A
G
H
T
D
V
V
P
T
-------
G
PV
E
---
K
W
D
----
S
P
P
F
E
P
A
E
-
R
--
D
G
R
L
Y
G
R
G
A
----
A
D
M
K
T
S
I
A
C
F
V
T
A
C
E
R
F
V
A
K
H
P
N
H
Q
G
S
I
A
L
L
I
T
S
D
E
E
G
D
-----
A
L
D
G
T
T
K
-
V
V
D
V
L
K
A
R
-----
D
----
E
L
I
D
Y
C
I
V
G
E
P
-
T
A
----
V
DKLGD
M
I
K
N
---------------------------------------------------------------------------
G
R
R
G
S
-----
L
S
G
--
N
L
T
V
K
G
----
K
--
Q
-
G
--
H
I
A
------
Y
P
H
-
L
-
A
I
N
P
V
H
T
F
A
P
A
L
L
E
L
T
Q
E
------------------------------------------
V
W
D
-------------
E
-----------------------------------------------
G
N
E
Y
F
P
P
T
S
F
Q
I
S
N
I
N
G
----
G
-------------
T
GAT---
N
V
I
P
G
E
L
N
V
K
F
N
F
R
F
S
T
E
S
T
E
A
G
L
K
Q
R
V
H
A
I
L
D
K
-
H
----
G
--------
V
--------
Q
Y
D
--
L
Q
W
S
---
C
S
G
Q
-
P
F
L
T
Q
-
A
-
G
K
L
T
D
V
A
R
A
A
I
A
E
T
C
G
I
E
----
A
E
-
L
S
---
T
---
T
G
G
T
S
--
D
G
R
F
-
I
-
K
A
I
AQ-
E
L
--
I
---
E
L
G
P
S
N
A
----
T
I
H
Q
I
N
E
N
V
R
L
N
D
I
P
K
L
S
A
V
Y
E
G
I
L
A
R
L
L
----
41
HHSearch
63.43
19%
15
- C1 -
-
3DLJ
-
CNDP1_HUMAN
A:
[13-483]
--
L
E
K
V
F
Q
Y
I
D
L
H
Q
D
E
F
V
Q
T
L
K
E
W
V
A
I
E
S
D
S
V
Q
P
V
----
P
R
F
R
Q
-
E
L
F
R
M
M
A
V
A
A
D
T
L
Q
R
L
G
A
------
R
-
V
A
S
V
----------------------
D
MGPQQLG
Q
S
L
P
--
I
P
------
P
V
I
L
A
E
L
-
G
SD
P
--
T
K
G
T
V
C
F
Y
G
H
L
D
V
Q
P
A
-------
D
RG
D
---
G
W
L
----
T
D
P
Y
V
L
T
E
-
V
--
D
G
K
L
Y
G
R
G
A
----
T
D
N
K
G
P
V
L
A
W
I
N
A
V
S
A
F
R
A
L
E
Q
D
L
P
V
N
I
K
F
I
I
E
G
M
E
E
A
G
-----
S
-
V
A
L
E
E
-
L
V
E
K
E
K-------
D
RFF-
S
G
V
D
Y
I
V
I
S
D
N
-
L
W
ISK
P
A
------
I
T
Y
G
T
R
---------------------------------------------------------------------------
G
N
-----
S
Y
F
--
M
V
E
V
K
C
----
R
DQ
D
-
F
--
H
S
G
------
T
F
G
-
G
I
L
H
E
P
M
A
D
L
V
A
L
L
G
S
L
V
D
S
S
GHILVPGIYDEVVPLT
E
E
---
E
I
-----------------
N
T
Y
K
A
I
H
----------
L
D
---
L
E
E
---
Y
R
N
S
S
R
------
V
E
K
----
F
LF
D
T
K
E
---------
E
I
L
M
H
L
W
R
Y
P
S
L
S
I
H
G
I
E
G
----
A
FDEPG--------
T
K-----
T
V
I
P
G
R
V
I
G
K
F
S
I
R
L
V
P
H
M
N
V
S
A
V
E
K
Q
V
T
R
H
L
E
D
-
V
----
F
S
K
R
NSS
N
K
M
--------
V
V
S
--
M
--
T
---
L
G
L
H
-
P
W
I
A
N
I
D
-
D
T
Q
Y
L
A
A
K
R
A
I
R
T
V
F
G
T
E
----
P
D
-
M
I
---
R
----
D
G
S
T
I
P
I
A
K
M
-
F
-
Q
E
I
VH-----
V
V
L
I
P
L
G
A
V
D
D
----
G
E
H
S
Q
N
E
K
I
N
R
W
N
Y
I
E
G
T
K
L
F
A
A
F
F
L
E
M
A
Q
---
37
HHSearch
63.10
20%
25
- C1 -
-
3IC1
1
DAPE_HAEIN
A:
[2-376]
-------------
K
E
K
V
V
S
L
A
Q
D
L
I
R
R
P
S
I
S
P
N
-------------
D
E
G
C
Q
Q
I
I
A
E
R
L
E
K
L
G
F
------
Q
-
I
E
W
M
P
F
--------------------
N
-------------
D
T
------
L
N
L
W
A
K
H
-
G
--
T
--
S
E
P
V
I
A
F
A
G
H
T
D
V
V
P
T
-------
G
DE
N
---
Q
W
S
----
S
P
P
F
S
A
E
I
-
I
--
D
G
M
L
Y
G
R
G
A
----
A
D
M
K
G
S
L
A
A
M
I
V
A
A
E
E
Y
V
K
A
N
P
N
H
K
G
T
I
A
L
L
I
T
S
D
E
E
A
T
-----
A
K
D
G
T
I
H
-
V
V
E
T
L
M
A
R
-----
D
----
E
K
I
T
Y
C
M
V
G
E
P
-
S
S
----
A
------
K
N
---
L
G
D
V
---
V
---
K
------------------------------------------------------------
N
G
R
R
G
S
-----
I
T
G
--
N
L
Y
I
Q
G
----
I
--
Q
-------------
Y
P
H
-
L
-
A
E
N
P
I
H
K
A
A
L
F
L
Q
E
L
T
T
Y
-------------------------------------------
Q
W
--
D
----------
K
-----------------------------------------------
G
N
E
F
F
P
P
T
S
L
Q
I
A
N
I
H
A
----
G
-------------
T
GS-----
V
I
P
A
E
L
Y
I
Q
F
N
L
R
Y
C
T
E
V
T
D
E
I
I
K
Q
K
V
A
E
M
L
E
K
-
H
----
N
--------
L
--------
K
Y
R
I
E
W
--
N
---
L
S
G
K
-
P
F
L
T
K
P
--
G
K
L
L
D
S
I
T
S
A
I
E
E
T
I
G
I
T
----
P
K
-
A
E
---
T
---
G
G
G
T
S
--
D
G
R
F
-
I
-
A
L
MG
A
-
E
V
--
V
---
E
F
G
P
L
N
S
----
T
I
H
K
V
N
E
C
V
S
V
E
D
L
G
K
C
G
E
I
Y
H
K
M
L
V
N
L
L
D
---
35
HHSearch
62.97
22%
33
- C1 -
-
5UEJ
-
DAPE_NEIMB
B:
[5-380]
------------
T
E
T
Q
S
L
E
L
A
K
E
L
I
S
R
P
S
V
T
P
D
-------------
D
R
D
C
Q
K
L
L
A
E
R
L
H
K
I
G
F
------
A
-
A
E
E
L
H
F
--------------------
G
-------------
D
T
------
K
N
I
W
L
R
R
-
G
--
T
--
K
A
P
V
V
C
F
A
G
H
T
D
V
V
P
T
-------
G
PV
E
---
K
W
D
----
S
P
P
F
E
P
A
E
-
R
--
D
G
R
L
Y
G
R
G
A
----
A
D
M
K
T
S
I
A
C
F
V
T
A
C
E
R
F
V
A
K
H
P
N
H
Q
G
S
I
A
L
L
I
T
S
D
E
E
G
D
-----
A
L
D
G
T
T
K
-
V
V
D
V
L
K
A
R
-----
D
----
E
L
I
D
Y
C
I
V
G
E
P
-
T
A
----
V
DKLGDM
I
K
N
---------------------------------------------------------------------------
G
R
R
G
S
-----
L
S
G
--
N
L
T
V
K
G
----
K
--
Q
-
G
--
H
I
A
------
Y
P
H
-
L
-
A
I
N
P
V
H
T
F
A
P
A
L
L
E
L
T
Q
E
------------------------------------------
V
W
D
-------------
E
-----------------------------------------------
G
N
E
Y
F
P
P
T
S
F
Q
I
S
N
I
N
G
----
G
-------------
T
GAT---
N
V
I
P
G
E
L
N
V
K
F
N
F
R
F
S
T
E
S
T
E
A
G
L
K
Q
R
V
H
A
I
L
D
K
-
H
----
G
--------
V
--------
Q
Y
D
--
L
--
Q
W
S
-
C
S
G
Q
-
P
F
L
T
Q
-
A
-
G
K
L
T
D
V
A
R
A
A
I
A
E
T
C
G
I
E
----
A
E
-
L
S
---
T
---
T
G
G
T
S
--
D
G
R
F
-
I
-
K
A
I
AQ-
E
L
--
I
---
E
L
G
P
S
N
A
----
T
I
H
Q
I
N
E
N
V
R
L
N
D
I
P
K
L
S
A
V
Y
E
G
I
L
A
R
L
L
A
---
38
HHSearch
61.28
20%
26
- C1 -
-
3ISZ
-
DAPE_HAEIN
B:
[2-376]
-------------
K
E
K
V
V
S
L
A
Q
D
L
I
R
R
P
S
I
S
P
N
-------------
D
E
G
C
Q
Q
I
I
A
E
R
L
E
K
L
G
F
------
Q
-
I
E
W
M
PF--------------------
N
-------------
D
T
------
L
N
L
W
A
K
H
-
G
--
T
--
S
E
P
V
I
A
F
A
G
H
T
D
V
V
P
T
-------
G
DE
N
---
Q
W
S
----
S
P
P
F
S
A
E
I
-
I
--
D
G
M
L
Y
G
R
G
A
----
A
D
M
K
G
S
L
A
A
M
I
V
A
A
E
E
Y
V
K
A
N
P
N
H
K
G
T
I
A
L
L
I
T
S
D
E
E
A
T
-----
A
K
D
G
T
I
H
-
V
V
E
T
L
M
A
R
-----
D
----
E
K
I
T
Y
C
M
V
G
E
P
-
S
S
----
A
------
K
N
---
L
G
D
V
---
V
---
K
------------------------------------------------------------
N
G
R
R
G
S
-----
I
T
G
--
N
L
Y
I
Q
G
----
I
--
Q
--------------
P
H
-
L
-
A
E
N
P
I
H
K
A
A
L
F
L
Q
E
L
T
T
Y
-------------------------------------------
Q
W
--
D
----------
K
-----------------------------------------------
G
N
E
F
F
P
P
T
S
L
Q
I
A
N
I
H
A
----
G
---------------------
V
I
P
A
E
L
Y
I
Q
F
N
L
R
Y
C
T
E
V
T
D
E
I
I
K
Q
K
V
A
E
M
L
E
K
-
H
----
N
--------
L
--------
K
Y
R
I
E
W
--
N
---
L
S
G
K
-
P
F
L
T
K
P
--
G
K
L
L
D
S
I
T
S
A
I
E
E
T
I
G
I
T
----
P
K
-
A
E
---
T
---
G
G
G
T
S
--
D
G
R
F
-
I
-
A
L
MG
A
-
E
V
--
V
---
E
F
G
P
L
N
S
----
T
I
H
K
V
N
E
C
V
S
V
E
D
L
G
K
C
G
E
I
Y
H
K
M
L
V
N
L
L
D
---
54
Fugue
60.72
17%
-31
- C1 -
-
2F8H
-
?
A:
[0-365]
--------
H
M
T
D
L
L
A
S
T
L
E
H
L
E
T
L
V
S
F
D
T
------
R
N
P
P
R
A
I
A
A
--
E
G
G
I
F
D
Y
L
R
A
Q
L
P
G
F
Q
V
------
E
-
V
I
D
H
----------------------
G
-------------
D
G
------
A
V
S
L
-
Y
A
-
V
--
R
--
G
T
P
K
Y
L
F
N
V
H
L
D
T
V
P
D
-------
S
--
P
---
H
W
S
----
A
D
P
H
V
M
R
R
-
T
--
E
D
R
V
I
G
L
G
V
----
C
D
I
K
G
A
A
A
A
L
V
A
A
A
N
-------
A
G
D
G
D
A
A
F
L
F
S
S
D
E
E
A
N
D----
P
-
R
C
I
A
A
-
F
L
A
R
---------
G
----
L
P
Y
D
A
V
L
V
A
E
P
T
M
S
----
E
------
A
V
L
A
H
R
G
I
S
S
V
L
M
---
R
F
A
G
R
-
A
G
-
D
-
P
-----------------------
A
A
S
A
L
H
Q
A
M
R
W
G
G
K
A
L
D
H
V
E
S
L
A
H
A
R
F
G
G
L
T
G
-----
L
R
F
--
N
I
G
R
V
D
----
G
--
G
-
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
A
------
N
M
I
A
P
A
A
E
L
R
F
G
F
R
P
L
P
S
M
D
V
D
G
L
L
A
T
F
A
G
F
A
D
P
-
A
----
A
--------
A
--------
H
F
E
E
-
T
--
F
---
R
G
P
S
L
P
S
G
D
I
A
R
-
A
E
E
R
R
L
A
A
R
D
V
A
D
A
L
D
L
P
----
I
G
-
N
A
---
V
---
D
F
W
T
E
--
A
S
L
F
-
S
-
A
-----
G
G
--
Y
---
T
A
L
V
Y
G
P
G
D
I
A
Q
A
H
T
A
D
E
F
V
T
L
A
Q
L
Q
R
Y
V
E
S
V
N
R
I
I
N
G
S
-----
3
PsiBlast_PDB
60.17
40%
-
- C1 -
-
3KHZ
-
PEPVL_STAAC
A:
[2-466]
-----
W
K
E
K
V
Q
Q
Y
E
D
Q
I
I
N
D
L
K
G
L
L
A
I
E
S
V
R
D
D
A
K
A
S
E
D
A
P
V
G
P
-
G
P
R
K
A
L
D
Y
M
Y
E
I
A
H
R
D
G
F
------
T
-
T
H
D
V
----------------------
D
-------------
H
I
------
A
G
R
I
-
E
A
-
G
--
K
--
G
N
D
V
L
G
I
L
C
H
V
D
V
V
P
A
-------
G
--
D
---
G
W
D
----
S
N
P
F
E
P
V
V
-
T
--
E
D
A
I
I
A
R
G
T
----
L
D
D
K
G
P
T
I
A
A
Y
Y
A
I
K
I
L
E
D
M
N
V
D
W
K
K
R
I
H
M
I
I
G
T
D
E
E
S
D
-----
W
-
K
C
T
D
R
-
Y
F
K
T
---------
E
----
E
M
P
T
L
G
F
A
P
D
A
-
E
F
----
P
------
C
I
H
G
E
K
G
I
T
T
F
D
L
VQN
K
L
T
E
D
Q
D
E
-
P
-
D
Y
E
L
I
T
F
K
S
G
E
R
Y
N
M
V
P
D
H
A
E
A
R
V
L
V
K
E
N
M
T
D
V
I
Q
D
--
F
E
Y
F
L
E
Q
N
H
L
Q
G
D
S
T
V
D
S
-----
G
I
L
--
V
L
T
V
E
G
----
K
--
A
-
V
--
H
G
M
------
D
P
S
-
I
-
G
V
N
A
G
L
Y
L
L
K
F
L
A
S
L
N
L
D
N
-----------------
N
---
A
Q
-----------------
A
F
V
A
F
S
N
----------
R
Y
---
L
F
N
---
S
--
D
F
G
------
E
-
K
----
M
--
G
--
M
---------
K
F
H
T
D
V
M
G
D
V
T
T
N
I
G
V
I
T
Y
----
D
----------------------
N
E
N
A
G
L
F
G
I
N
L
A
Y
P
E
G
F
E
F
E
K
A
M
D
R
F
A
N
E
I
Q
Q
-
Y
----
G
--------
F
--------
E
V
K
L
-
G
------
K
V
Q
P
-
P
H
Y
V
D
K
N
-
D
P
F
V
Q
K
L
V
T
A
Y
R
N
Q
T
------------------------------------------------------------
H
Q
K
N
E
Y
I
T
K
K
Q
L
F
N
A
T
S
I
Y
L
E
A
I
Y
S
L
C
----
61
Fugue
59.64
20%
29
- C1 -
-
5K8P
4
NAAA_BRASZ
A:
[5-425]
N
D
V
A
K
V
M
K
T
L
D
G
M
R
E
G
L
I
Q
T
A
V
E
L
G
S
I
-----------
E
A
P
T
G
R
-
E
-
G
A
A
G
D
Y
V
Y
E
W
M
A
R
N
G
F
G
P
E
R
V
G
V
-
F
D
D
R
----------------------
F
-------------
N
V
------
V
G
R
L
-
R
G
-
T
--
G
--
G
G
A
S
L
S
F
N
S
H
L
D
T
I
M
A
REDTARF
A
--
D
---
A
N
D
----
R
I
Y
H
E
A
W
H
-
E
--
E
G
R
I
Y
G
Y
S
V
----
V
N
C
K
G
P
M
A
C
W
L
I
A
A
K
A
L
K
E
A
G
A
A
L
K
G
D
V
V
L
T
A
V
C
G
E
I
----------------------------
D
----
C
E
P
-----------------------
V
D
E
F
Q
G
H
D
Y
L
A
E
---
D
I
------------------
G
A
R
Y
A
I
S
H
G
--------
A
I
S
D
Y
A
L
V
A
E
A
T
N
F
K
-------
P
A
W
V
E
A
G
K
-----
V
F
L
--
K
V
T
V
F
A
G
PSR
Y
--
T
-
P
--
Y
V
P
------
R
P
V
-
A
-
A
L
D
S
P
N
A
I
V
R
M
A
K
L
V
E
A
L
E
-----------------
E
---
W
A
-----------------
D
N
Y
E
K
R
------------
Y
---
T
R
E
---
Y
--
G
G
G
------
T
V
V
----
P
--
K
--
V
---------
A
I
G
A
I
R
G
G
V
--------
P
Y
----
K
-------------
I
------
Y
A
F
P
E
L
C
S
I
Y
M
D
I
R
L
N
P
D
T
N
P
L
V
V
Q
R
E
V
E
A
V
V
S
K
-
L
----
G
--------
L
--------
K
A
E
V
-
K
--
P
---
F
L
F
R
-
R
G
Y
E
A
Q
G
I
E
P
L
Q
N
A
L
E
V
A
H
R
E
V
V
G
R
P
TERP
G
S
-
P
E
---
C
S
MW
R
D
T
N
P
--
Y
N
E
L
-
G
-
I
-----
P
S
--
L
---
T
Y
G
C
-----
G
G
G
A
G
G
G
N
T
Y
F
L
V
D
D
M
L
K
A
A
K
V
Y
A
M
T
A
M
D
L
C
N
RTP
42
HHSearch
59.22
16%
14
- C1 -
-
4G1P
2
DUG1_YEAST
A:
[6-476]
---
T
S
V
F
Q
K
I
D
S
L
K
P
Q
F
F
S
R
L
T
K
A
I
Q
I
P
A
V
S
S
D
E
S
------
L
R
S
-
K
V
F
D
K
A
K
F
I
S
E
Q
L
S
Q
S
G
F
------
H
D
I
K
M
V
----------------------
D
LGIQPPP------
S
T
PNLSLP
P
V
I
L
S
R
F
-
G
SD
P
--
S
K
K
T
V
L
V
Y
G
H
Y
D
V
Q
P
A
-------
Q
LE
D
---
G
W
D
----
T
E
P
F
K
L
V
I
-
D
EA
K
G
I
M
K
G
R
G
V
----
T
D
D
T
G
P
L
L
S
W
I
N
V
V
D
A
F
K
A
S
G
Q
E
F
P
V
N
L
V
T
C
F
E
G
M
E
E
S
G
-----
S
-
L
K
L
D
E
-
L
I
K
K
E
--------
A
NGYF
K
G
V
D
A
V
C
I
S
D
N
-
Y
W
----
L
GTK
K
P
V
L
T
Y
G
---------------------------------------------------------------------------
L
R
G
C
-----
N
Y
Y
--
Q
T
I
I
E
G
----
P
--
S
-
A
DL
H
S
G
------
I
F
G
G
V
-
V
A
E
P
M
I
D
L
M
Q
V
L
G
S
L
V
D
S
K
-----------------
G
KIL
I
D
GID--------------
E
M
V
A
P
L
T
----------
E
K
E
K
A
L
Y
K
---
D
--
I
E
F
S
V
----
E
-
E
L
N
A
A
T
--
G
--
S
KTSLYDK
K
E
D
I
L
M
H
R
W
R
Y
P
S
L
S
I
H
G
V
E
G
----
A
FSAQ---------
G
AK----
T
V
I
P
A
K
V
F
G
K
F
S
I
R
T
V
P
D
M
D
S
E
K
L
T
S
L
V
Q
K
H
C
D
A
-
K
----
F
K
S
L
NSP
N
K
C
--------
R
T
E
--
L
--
I
---
H
D
G
A
-
Y
W
V
S
D
P
F
-
N
A
Q
F
T
A
A
K
K
A
T
K
L
V
Y
G
V
D
----
P
D
-
F
T
---
R
---
E
G
G
S
I
--
P
I
T
L
-
T
F
Q
D
A
L
N
T
S
V
L
L
L
---
P
M
G
R
G
D
-
D
---
G
A
H
S
I
N
E
K
L
D
I
S
N
F
V
G
G
M
K
T
M
A
A
Y
L
Q
Y
Y
S
----
40
HHSearch
58.38
18%
25
- C1 -
-
2ZOG
2
CNDP2_MOUSE
A:
[7-476]
-
A
L
K
A
V
F
Q
Y
I
D
E
N
Q
D
R
Y
V
K
K
L
A
E
W
V
A
I
Q
S
V
S
A
W
P
E
------
K
R
G
-
E
I
R
R
M
M
E
V
A
A
A
D
V
Q
R
L
G
G
------
S
-
V
E
L
V
----------------------
D
I
G
K
Q
K
L
PDG
S
E
I
P
L
P
------
P
I
L
L
G
K
L
-
G
SD
P
--
Q
K
K
T
V
C
I
Y
G
H
L
D
V
Q
P
A
-------
A
LE
D
---
G
W
D
----
S
E
P
F
T
L
V
E
-
R
--
E
G
K
L
Y
G
R
G
S
----
T
D
D
K
G
P
V
A
G
W
M
N
A
L
E
A
Y
Q
K
T
G
Q
E
I
P
V
N
L
R
F
C
L
E
G
M
E
E
S
G
-----
S
-
E
G
L
D
E
-
L
I
F
A
Q
K-------
D
KFF-
K
D
V
D
Y
V
C
I
S
D
N
-
Y
W
----
L
GKN
K
P
C
I
T
Y
G
L
R
---------------------------------------------------------------------------
G
I
-----
C
Y
F
F
I
E
V
E
C
S
D
----
K
--
D
-
L
--
H
S
G
------
V
Y
G
-
G
S
V
H
E
A
M
T
D
L
I
S
L
M
G
C
L
V
D
K
K
---------------------
G
K
-----------------
I
L
I
P
G
I
N
DAVAPVT
D
E
E
H
A
---
L
Y
D
---
H
I
D
F
D
M
E
E
F
A
--
K
-
D
----
V
--
G
--
A
ETLLHSC
K
K
D
I
L
M
H
R
W
R
Y
P
S
L
S
L
H
G
I
E
G
AFSG
S
-------------
G
AK----
T
V
I
P
R
K
V
V
G
K
F
S
I
R
L
V
P
D
M
I
P
E
V
V
S
E
Q
V
S
S
Y
L
S
K
-
K
----
F
A
E
L
QSP--
N
--------
K
F
K
--
V
--
Y
M
G
-
H
G
G
K
-
P
W
V
S
D
F
N
-
H
P
H
Y
Q
A
G
R
R
A
L
K
T
V
F
G
V
E
----
P
D
-
L
T
---
R
---
E
G
G
S
I
--
P
V
T
L
T
F
-
Q
E
A
T
G
K
N
V
--
M
---
L
L
P
V
G
S
A
D
D
--
G
A
H
S
Q
N
E
K
L
N
R
L
N
Y
I
E
G
T
K
M
L
A
A
Y
L
Y
E
V
S
Q
---
2
PsiBlast_PDB
58.31
40%
264
- C1 -
-
3KHX
-
PEPVL_STAAC
A:
[2-466]
-----
W
K
E
K
V
Q
Q
Y
E
D
Q
I
I
N
D
L
K
G
L
L
A
I
E
S
V
R
D
D
A
K
A
S
E
D
A
P
V
G
P
-
G
P
R
K
A
L
D
Y
M
Y
E
I
A
H
R
D
G
F
------
T
-
T
H
D
V
----------------------
D
-------------
H
I
------
A
G
R
I
-
E
A
-
G
--
K
--
G
N
D
V
L
G
I
L
C
H
V
D
V
V
P
A
-------
G
--
D
---
G
W
D
----
S
N
P
F
E
P
V
V
-
T
--
E
D
A
I
I
A
R
G
T
----
L
D
D
K
G
P
T
I
A
A
Y
Y
A
I
K
I
L
E
D
M
N
V
D
W
K
K
R
I
H
M
I
I
G
T
D
E
E
S
D
-----
W
-
K
C
T
D
R
-
Y
F
K
T
---------
E
----
E
M
P
T
L
G
F
A
P
D
A
-
E
F
----
P
------
C
I
H
G
E
K
G
I
T
T
F
D
L
VQN
K
L
T
E
D
Q
D
E
-
P
-
D
Y
E
L
I
T
F
K
S
G
E
R
Y
N
M
V
P
D
H
A
E
A
R
V
L
V
K
E
N
M
T
D
V
I
Q
D
--
F
E
Y
F
L
E
Q
N
H
L
Q
G
D
S
T
V
D
S
-----
G
I
L
--
V
L
T
V
E
G
----
K
--
A
-
V
--
H
--------------
G
V
N
A
G
L
Y
L
L
K
F
L
A
S
L
N
L
D
N
-----------------
N
---
A
Q
-----------------
A
F
V
A
F
S
N
----------
R
Y
---
L
F
N
---
S
--
D
F
G
------
E
-
K
----
M
--
G
--
M
---------
K
-------
D
V
T
T
N
I
G
V
I
T
Y
----
D
----------------------
N
E
N
A
G
L
F
G
I
N
L
R
Y
P
E
G
F
E
F
E
K
A
M
D
R
F
A
N
E
I
Q
Q
-
Y
----
G
--------
F
--------
E
V
K
L
-
G
------
K
V
Q
P
-
P
H
Y
V
D
K
N
-
D
P
F
V
Q
K
L
V
T
A
Y
R
N
Q
T
N
------------------------------------------------------------
Q
K
N
E
Y
I
T
K
K
Q
L
F
N
A
T
S
I
Y
L
E
A
I
Y
S
L
C
----
47
HHSearch
58.19
17%
7
- C1 -
-
5K8P
3
NAAA_BRASZ
C:
[7-422]
--
V
A
K
V
M
K
T
L
D
G
M
R
E
G
L
I
Q
T
A
V
E
L
G
S
I
E
A
P
T
G
R
-------------
E
G
A
A
G
D
Y
V
Y
E
W
M
A
R
N
G
F
------
G
-
P
E
R
V
G
VF-------------------
D
-------------
D
R
------
F
N
V
V
G
R
L
R
G
T-
G
--
G
G
A
S
L
S
F
N
S
H
L
D
T
I
M
A
-------
R
--
E
DTA
R
F
A
DAND
R
I
Y
H
E
A
W
H
-
E
--
E
G
R
I
Y
G
Y
S
V
----
V
N
C
K
G
P
M
A
C
W
L
I
A
A
K
A
L
K
E
A
G
A
A
L
K
G
D
V
V
L
T
A
V
C
G
E
I
D
C
E
P
V
DE
F
-
Q
G
H
D
Y
-
L
A
E
D
IG
A
R
Y
A
I
S
H
G
----
A
I
S
D
Y
A
L
V
A
E
A
-
T
N
----
F
K-----
P
A
W
V
---------------------------------------------------------------------------
E
A
G
K
-----
V
F
L
--
K
V
T
V
F
A
----
G
--
P
S
R
--
Y
T
P
YVPRPV
A
A
L
-
D
-
S
P
N
A
I
V
R
M
A
K
L
V
E
A
L
E
E
W
-------------------------------------------
A
D
N
Y
E
----------
K
----------
R
--
Y
T
------------------------------
R
E
Y
G
G
G
T
V
V
P
K
V
A
I
G
A
I
R
G
----
G
-------------
V
PYKI--
Y
A
F
P
E
L
C
S
I
Y
M
D
I
R
L
N
P
D
T
N
P
L
V
V
Q
R
E
V
E
A
V
V
S
K
-
L
----
G
--------
L
--------
K
A
E
V
K
P
--
F
---
L
F
R
R
-
G
Y
E
A
Q
G
I
-
E
P
L
Q
N
A
L
E
V
A
H
R
E
V
V
G
R
P
----
T
E
-
R
P
G
S
P
E
---
C
S
M
W
R
--
D
T
N
P
-
Y
-
N
E
L
GI-
P
S
--
L
---
T
Y
G
C
G
G
-----
G
A
G
G
G
N
T
Y
F
L
V
D
D
M
L
K
A
A
K
V
Y
A
M
T
A
M
D
L
C
N
---
49
HHSearch
58.14
16%
26
- C1 -
-
2POK
2
?
A:
[40-481]
----------
D
H
V
A
Q
H
Y
F
E
V
L
R
T
L
I
S
K
K
S
V
F
A
Q
Q
---------
V
-
G
L
K
E
V
A
N
Y
L
G
E
I
F
K
R
V
G
A
------
E
-
V
E
I
D
----------------------
E
SY-----------
T
A
------
P
F
V
M
A
H
F
K
S
--
S
RP
D
A
K
T
L
I
F
Y
N
H
Y
D
T
V
P
A
-------
D
GD
Q
---
V
W
T
----
E
D
P
F
T
L
S
V
-
R
--
N
G
F
M
Y
G
R
G
V
----
D
D
D
K
G
H
I
T
A
R
L
S
A
L
R
K
Y
M
Q
H
H
D
D
L
P
V
N
I
S
F
I
M
E
G
A
E
E
S
A
-----
S
-
T
D
L
D
K
-
Y
L
E
K
H
--------
A
DKL-
R
G
A
D
L
L
V
W
E
Q
G
-
T
K
----
N
ALE
Q
L
E
I
S
G
G
---------------------------------------------------------------------------
N
K
G
I
-----
V
T
F
--
D
A
K
V
K
S
AD--
V
--
D
-
I
--
H
S
S
------
Y
G
G
-
V
-
V
E
S
A
P
W
Y
L
L
Q
A
L
Q
S
L
R
A
A
D
-----------------
G
---
R
I
LVEGLYEEVQEPN
E
R
E
M
A
L
L
E
T
Y
G
----------
Q
R
---
N
P
E
E
V
S
R
--
I
Y
G
LELPLL
Q
-
E
----
E
--
R
--
M
---------
A
F
L
K
R
F
F
F
D
P
A
L
N
I
E
G
I
Q
S
----
G
-------------
Y
QGQGVK
T
I
L
P
A
E
A
S
A
K
L
E
V
R
L
V
P
G
L
E
P
H
D
V
L
E
K
I
R
K
Q
L
D
K
-
N
----
G
FDK-----
V
--------
E
L
Y
--
Y
--
T
---
L
G
E
M
-
S
Y
R
S
D
M
S
-
A
P
A
I
L
N
V
I
E
L
A
K
K
F
Y
P
Q
G
V
S
--
V
L
-
P
T
---
T
---
A
G
T
G
P
--
M
H
T
V
-
F
-
D
A
LE
V
-
P
M
--
V
---
A
F
G
L
G
N
A
N
S
--
R
D
H
G
G
D
E
N
V
R
I
A
D
Y
Y
T
H
I
E
L
V
E
E
L
I
R
S
Y
E
----
51
HHSearch
57.92
21%
33
- C1 -
-
3RZA
7
?
A:
[19-393]
---------
G
M
I
N
E
Q
R
L
L
N
T
F
L
E
L
V
Q
I
D
S
E
T
G
N
-------------
E
S
T
I
Q
P
I
L
K
E
K
F
I
A
L
G
L
------
D
-
V
K
E
D
EAAKHPKLG
A
------------
N
-------------
N
L
------
V
C
T
M
-
N
S
-
T
IE----
V
P
K
L
Y
L
T
S
H
M
D
T
V
V
P
-------
A
-------
I
N
----
V
K
P
I
--
V
K
-
D
--
D
G
Y
I
Y
S
D
G
T
TILG
A
D
D
K
A
G
L
A
A
M
L
E
V
L
Q
V
I
K
E
Q
Q
-
I
P
H
G
Q
I
Q
F
V
I
T
V
G
E
E
S
G
-----
L
-
I
G
A
K
E
-
L
N
S
E
---------
L
----
L
D
A
D
F
G
Y
A
I
D
A
-
S
A
----
D
VG
T
---
T
V
V
G
---------------------------------------------------------------------------
A
P
T
Q
-----
M
L
I
--
S
A
K
I
I
G
----
K
--
T
-
A
--
H
A
S
------
T
P
K
-
E
-
G
V
S
A
I
N
I
A
A
K
A
I
S
R
M
K
L
G
-------------------------------------------
Q
-----------------------------------------------------------------
V
D
E
I
T
T
A
N
I
G
K
F
H
G
----
G
-------------
S
A
T----
N
I
V
A
D
E
V
I
L
E
A
E
A
R
S
H
D
P
E
R
I
K
T
Q
V
K
H
M
T
D
V
F
E
T
-
T
A
S
E
L
G
G
K
------
A
--------
E
V
T
--
V
--
E
---
Q
S
Y
P
-
G
F
K
I
N
D
N
-
E
A
V
V
K
I
A
Q
E
S
A
R
N
-
L
G
L
S
----
A
N
-
T
I
---
I
---
S
G
G
G
S
--
D
G
S
I
-
I
-
N
T
F
GI-
P
S
--
V
---
I
L
G
V
G
Y
E
----
K
I
H
T
T
N
E
R
M
P
I
K
S
L
N
L
L
A
S
Q
V
L
E
I
I
K
I
V
A
R
---
46
HHSearch
57.61
17%
10
- C1 -
-
5K8O
2
NAAA_BRASZ
D:
[7-422]
--
V
A
K
V
M
K
T
L
D
G
M
R
E
G
L
I
Q
T
A
V
E
L
G
S
I
E
A
P
T
G
R
-------------
E
G
A
A
G
D
Y
V
Y
E
W
M
A
R
N
G
F
------
G
-
P
E
R
V
GVF-------------------
D
DRF----------
N
V
------
V
G
R
L
-
R
G
-
T
--
G
--
G
G
A
S
L
S
F
N
S
H
L
D
T
I
M
A
-------
R
--
E
DTA
R
F
A
DAND
R
I
Y
H
E
A
W
H
-
E
--
E
G
R
I
Y
G
Y
S
V
----
V
N
C
K
G
P
M
A
C
W
L
I
A
A
K
A
L
K
E
A
G
A
A
L
K
G
D
V
V
L
T
A
V
C
G
E
I
D
C
EPVDE
F
-
Q
G
H
D
Y
-
L
A
E
D
IGARYAISH
G
----
A
I
S
D
Y
A
L
V
A
E
A
-
T
N
----
F
K-----
P
A
W
V
---------------------------------------------------------------------------
E
A
G
K
-----
V
F
L
--
K
V
T
V
F
A
----
G
--
P
S
R
--
Y
T
P
YVPRPV
A
A
L
-
D
-
S
P
N
A
I
V
R
M
A
K
L
V
E
A
L
E
E
W
-------------------------------------------
A
D
N
Y
E
----------
K
----------
R
--
Y
T
------------------------------
R
E
Y
G
G
G
T
V
V
P
K
V
A
I
G
A
I
R
G
----
G
-------------
V
PYKI--
Y
R
F
P
E
L
C
S
I
Y
M
D
I
R
L
N
P
D
T
N
P
L
V
V
Q
R
E
V
E
A
V
V
S
K
-
L
----
G
--------
L
--------
K
A
E
V
K
P
--
F
---
L
F
R
R
-
G
Y
E
A
Q
G
I
-
E
P
L
Q
N
A
L
E
V
A
H
R
E
V
V
G
R
P
----
T
E
R
P
G
SP-
E
---
C
S
M
W
R
--
D
T
N
P
-
Y
-
N
ELGI-
P
S
--
L
---
T
Y
G
C
G
G
-----
G
A
G
G
G
N
T
Y
F
L
V
D
D
M
L
K
A
A
K
V
Y
A
M
T
A
M
D
L
C
N
---
39
HHSearch
57.35
18%
23
- C1 -
-
2ZOF
2
CNDP2_MOUSE
B:
[7-476]
-
A
L
K
A
V
F
Q
Y
I
D
E
N
Q
D
R
Y
V
K
K
L
A
E
W
V
A
I
Q
S
V
S
A
W
P
E
------
K
R
G
-
E
I
R
R
M
M
E
V
A
A
A
D
V
Q
R
L
G
G
------
S
-
V
E
L
V
----------------------
D
IGKQKLPDGSEIP
L
P
------
P
I
L
L
G
K
L
-
G
SD
P
--
Q
K
K
T
V
C
I
Y
G
H
L
D
V
Q
P
A
-------
A
LE
D
---
G
W
D
----
S
E
P
F
T
L
V
E
-
R
--
E
G
K
L
Y
G
R
G
S
----
T
D
D
K
G
P
V
A
G
W
M
N
A
L
E
A
Y
Q
K
T
G
Q
E
I
P
V
N
L
R
F
C
L
E
G
M
E
E
S
G
-----
S
-
E
G
L
D
E
-
L
I
F
A
QK-------
D
KFF-
K
D
V
D
Y
V
C
I
S
D
N
-
Y
W
----
L
GKNKPC
I
T
Y
G
L
R
---------------------------------------------------------------------------
G
I
-----
C
Y
F
FI
E
V
E
C
S
D
----
K
--
D
-
L
--
H
S
G
------
V
Y
G
-
G
S
V
H
E
A
M
T
D
L
I
S
L
M
G
C
L
V
D
K
K
---------------------
G
K
-----------------
I
L
I
P
G
I
N
DAVAPVTDEE
H
A
---
L
Y
D
---
H
ID
F
D
M
EEFA--
K
-
D
----
V
--
G
--
A
ETLLHSCKK
D
I
L
M
H
R
W
R
Y
P
S
L
S
L
H
G
I
E
G
AFSG
S
-------------
G
AK----
T
V
I
P
R
K
V
V
G
K
F
S
I
R
L
V
P
D
M
I
P
E
V
V
S
E
Q
V
S
S
Y
L
S
K
-
K
----
F
AELQSP--
N
--------
K
F
K
--
V
--
Y
MG-
H
G
G
K
-
P
W
V
S
D
F
N
-
H
P
H
Y
Q
A
G
R
R
A
L
K
T
V
F
G
V
E
----
P
D
-
L
T
---
R
---
E
G
G
S
I
--
P
V
T
L
T
F
-
Q
EATGK
N
V
--
M
---
L
L
P
V
G
S
A
D
D
--
G
A
H
S
Q
N
E
K
L
N
R
L
N
Y
I
E
G
T
K
M
L
A
A
Y
L
Y
E
V
S
Q
---
34
HHSearch
57.33
17%
24
- C1 -
-
3PFO
5
?
B:
[15-429]
---
Q
S
L
R
A
A
V
D
R
N
F
N
D
Q
V
A
F
L
Q
R
M
V
Q
F
R
S
V
R
G
E
-------------
E
A
P
Q
Q
E
W
L
A
Q
Q
F
A
D
R
G
Y
------
K
-
V
D
T
F
SLADVDIASHPKAAPMDTIDPA
G
-------------
S
M
------
Q
V
V
A
-
T
A
D
S
--
D
G-
K
G
R
S
L
I
L
Q
G
H
I
D
V
V
P
E
-------
G
PV
D
---
L
W
S
----
D
P
P
Y
E
A
K
V
-
R
--
D
G
W
M
I
G
R
G
A
----
Q
D
M
K
G
G
V
S
A
M
I
F
A
L
D
A
I
R
T
A
G
Y
A
P
D
A
R
V
H
V
Q
T
V
T
E
E
E
S
T
-----
G
-
N
G
A
L
S
T
L
M
R
----------
G
----
Y
R
A
D
A
C
L
I
P
E
P
-
T
G
----
H
T-----
L
T
R
A
Q
V
---------------------------------------------------------------------------
G
A
-----
V
W
F
--
R
L
R
V
R
G
----
T
--
P
-
V
--
H
V
A
------
Y
S
E
-
T
-
G
T
S
A
I
L
S
A
M
H
L
I
R
A
F
E
E
Y
-------------------------------------------
T
K
E
L
N
----------
A
Q
---
A
V
R
---
D
----------------------------------
P
W
F
G
Q
V
K
N
P
I
K
F
N
V
G
I
I
K
G
----
G
-------------
D
WA----
S
S
T
A
A
W
C
E
L
D
C
R
L
G
L
L
T
G
D
T
P
Q
E
A
M
R
G
I
E
K
C
L
A
D
-
A
----
Q
--------
A
TDSFLSEN
P
A
E
--
L
--
V
WSG
F
Q
A
D
-
P
A
V
C
E
P
G
-
G
V
A
E
D
V
L
T
A
A
H
K
A
A
F
N
A
P
----
L
D
-
A
R
---
L
---
S
T
A
V
N
--
D
T
R
Y
-
Y
-
S
VDYGI
P
A
--
L
---
C
Y
G
P
Y
G
Q
----
G
P
H
A
F
D
E
R
I
D
L
E
S
L
R
K
T
T
L
S
I
A
L
F
V
A
E
W
C
G
---