@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TZE3: (2017-12-16 )
MEFRGGRKMEKIEWRKDKSYSMKKSPQILEVPKKSFFSIRGIGDPNQEDFKRRVACLYAVSYAIRMSPKKNWLIPDYQMYTVYPLEGQWGLQEKYLHEPVMKKEHFSYQLMIRQPDFVTEAIAQEAIQRSSKLPEDLKEQVVFKKMEEGLCAQILHVGPYAEEPATFEKLEAFIAKEGYERASKEHKEIYISDPRKSAPEKMKTILRVKIEKG
Atome Classification :
(20 SA)
------------------------.........10--......--..-----------20........30........40-......------..50....----..-----..60.....------------------..-.70..---......-80........90.---------------------.......100.......110.......120...-----------------....-----------------130.......-.140.......150.......160--.-.......170--.-.....-..-180--.-.--....-..190.......200...---....210.-----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------MEFRGGRKME
K
--
I
E
WRKD--KS-----------YSMKKSP
Q
I
LEVPKKS
F
F
S
I
RG-IGDP
N
Q
------
E
D
F
K
R
R
V
A
----
C
L
-----
Y
A
V
S
Y
A
I
RM------------------SP-KKNWL---IPDY
Q
M
-
Y
T
V
Y
PLEGQWG
L
Q
---------------------
E
K
Y
LHEP
V
M
KKEHF
S
Y
Q
L
M
IRQP
D
F
V
T
E
A
I
A
Q
E
-----------------
A
I
Q
R
-----------------
S
-SKL
P
E
D
L
K
-
E
Q
V
V
F
K
K
M
E
E
G
L
C
A
Q
I
L
HVGPY-A--E-EPA
T
F
E
K
L
-
E
--
A
-
F
I
A
K
E-
G
Y
-
E
R
---
A
-S--KEH
K
-
E
I
Y
ISDPRKS
A
P
E
K
M
K
T
I
---
L
R
V
K
IEKG-----------------------------
1
PsiBlast_PDB
80.76
36%
16
- C5 -
-
3B49
2
?
A:
[8-210]
----------------------------------
K
--
I
D
F
K
K
E
E
K
K
F
-----------
Y
A
P
K
R
K
P
E
R
I
F
V
P
E
M
N
F
L
M
V
D
G
-
K
G
D
P
D
G
------
E
E
Y
Q
K
A
V
Q
----
S
L
-----
Y
A
I
A
Y
T
I
K
M
------------------
S
K
-
M
G
E
T
R
---
L
D
G
Y
S
D
-
F
V
V
P
P
L
E
G
F
W
W
S
E
---------------------
G
K
F
---
D
L
K
D
R
D
A
W
L
W
T
S
I
L
R
Q
P
D
F
V
T
E
E
V
L
E
W
-----------------
A
K
E
V
-----------------
A
-
R
K
K
K
P
D
V
D
T
S
R
V
K
L
V
R
F
E
E
G
E
C
V
Q
M
M
H
V
G
P
F
-
S
--
E
-
E
V
H
T
V
A
E
M
-
H
--
Q
-
F
M
E
T
E
-
G
L
-
R
N
DTG
A
-
I
--
R
K
H
H
-
E
I
Y
L
S
D
P
R
K
A
N
P
E
K
M
K
T
I
---
L
R
L
P
V
--------------------------------
22
HHSearch
73.24
35%
57
- C5 -
-
3B49
2
?
A:
[8-211]
----------------------------------
K
--
I
D
F
K
K
E
E
K
K
F
-----------
Y
A
P
K
R
K
P
E
R
I
F
V
P
E
M
N
F
L
M
V
D
G
-
K
G
D
P
D
G
------
E
E
Y
Q
K
A
V
Q
----
S
L
-----
Y
A
I
A
Y
T
I
K
M
------------------
S
K
-
M
G
E
T
R
LDG
Y
S
D
F
V
V
-
P
----
P
L
E
G
F
W
-
W
---------------------
S
E
G
K
F
D
-
L
K
D
R
D
A
W
L
W
T
S
I
L
R
Q
P
D
F
V
T
E
E
V
L
E
W
-----------------
A
K
E
V
-----------------
A
R
K
K
K
P
D
V
D
T
-
S
R
V
K
L
V
R
F
E
E
G
E
C
V
Q
M
M
H
V
G
P
F
-
S
--
E
-
E
V
H
T
V
A
E
M
-
H
--
Q
-
F
M
E
T
E
-
G
L
-
R
N
---
D
T
G
AI
R
K
H
H
-
E
I
Y
L
S
D
P
R
K
A
N
P
E
K
M
K
T
I
---
L
R
L
P
V
S
-------------------------------
25
HHSearch
55.46
19%
-21
- C5 -
-
3E0H
-
?
A:
[6-157]
-------------------------------------------------------------
Q
F
V
C
E
L
K
E
L
A
P
V
P
A
L
L
I
R
T
-
Q
T
T
M
S
E
--------
L
G
S
L
F
E
A
G
Y
H
D
I
-----
L
Q
L
L
A
G
Q
G
K
------------------
S
P
-
S
G
-----------------
P
P
F
A
R
Y
F
-
G
---------------------
M
--------
S
A
G
T
F
E
V
E
F
G
F
P
V
E
G
G
V
----------------------------------------------------
E
G
S
-
G
R
V
V
T
G
L
T
P
S
G
K
A
A
S
S
L
Y
I
G
P
Y
-
G
--
E
-
I
E
A
V
Y
D
A
L
-
M
--
K
-
W
V
D
D
N
-
G
F
-
D
L
---
S
-
G
---
E
A
Y
-
E
I
Y
L
D
N
P
A
E
T
A
P
D
Q
L
R
T
R
---
V
S
L
M
L
H
E
------------------------------
23
HHSearch
51.63
19%
-8
- C5 -
-
2KCU
-
?
A:
[6-158]
-------------------------------------------------------------
Q
F
V
C
E
L
K
E
L
A
P
V
P
A
L
L
I
R
T
-
Q
T
A
M
S
E
--------
L
G
S
L
F
E
----
A
G
Y
H
D
I-
L
Q
L
L
A
G
Q
G
K
------------------
S
P
-
S
G
-----------------
P
P
F
A
R
Y
F
-
G
---------------------
M
--------
S
A
G
T
F
E
V
E
F
G
F
P
V
E
G
G
V
----------------------------------------------------
E
G
S
-
G
R
V
V
T
G
L
T
P
S
G
K
A
A
S
S
L
Y
I
G
P
Y
-
G
--
E
-
I
E
A
V
Y
D
A
L
-
M
--
K
-
W
V
D
D
N
-
G
F
-
D
L
---
S
-
G
---
E
A
Y
-
E
I
Y
L
D
N
P
A
E
T
A
P
D
Q
L
R
T
R
---
V
S
L
M
L
H
E
S
-----------------------------
30
HHSearch
47.93
16%
-41
- C5 -
-
5XQL
-
?
A:
[140-290]
--------------------------------------------------------------
M
H
A
R
I
V
E
R
P
A
F
S
V
V
G
M
E
Y
-
F
G
S
A
P
--------
T
I
G
Q
L
W
E
----
R
F
-----
I
P
R
E
H
E
I
A
G
------------------
K
H
-
D
P
----------------
E
V
S
Y
G
I
C
A
-
Q
-----------------------------
Q
P
N
G
E
F
H
Y
V
A
G
F
E
V
Q
E
G
W
----------------------------------------------------
P
V
P
-
E
G
M
V
R
F
Q
V
P
A
Q
K
Y
A
V
F
T
H
K
G
T
A
-
P
--
Q
-
I
A
E
S
F
Q
A
I
-
Y
--
S
H
L
L
A
E
R
-
G
L
-
E
P
---
K
-
A
--
G
V
D
F
-
E
Y
Y
D
Q
R
F
R
G
P
L
D
P
N
S
Q
V
D
---
L
Y
I
P
I
Y
-------------------------------
44
Fugue
47.18
13%
-64
- C5 -
-
1JYH
-
SBMC_ECOLI
A:
[1-155]
--------------------------------------------------------------
M
N
Y
E
I
K
Q
E
E
K
R
T
V
A
G
F
H
L
-
V
G
-
P
W
E
------
Q
T
V
K
K
G
F
E
----
Q
L
-----
M
M
W
V
D
S
K
N
I
------------------
V
P
-
K
E
W
V
A
---
V
Y
-----------------------------------------
Y
D
N
P
D
E
T
P
A
E
K
L
R
C
D
T
V
V
T
V
P
G
-------------------------------------------------
Y
F
T
L
P
E
N
S
-
E
G
V
I
L
T
E
I
T
G
G
Q
Y
A
V
A
V
A
R
V
V
G
-
D
--
D
-
F
A
K
P
W
Y
Q
F
F
N
--
S
-
L
L
Q
D
S
-
A
Y
-
E
M
---
L
-
P
--
K
P
C
F
-
E
V
Y
L
N
N
G
A
E
D
G
Y
W
D
I
E
M
Y
---
V
A
V
Q
P
K
-------------------------------
24
HHSearch
46.69
14%
-60
- C5 -
-
1JYH
-
SBMC_ECOLI
A:
[1-154]
--------------------------------------------------------------
M
N
Y
E
I
K
Q
E
E
K
R
T
V
A
G
F
H
L
-
V
G
P
W
E
Q
-------
T
V
K
K
G
F
E
----
Q
L
-----
M
M
W
V
D
S
K
N
I
------------------
V
P
--
K
-----------------
E
W
V
A
V
Y
Y
-
D
---------------------
N
P
D
----
E
T
P
A
E
K
L
R
C
D
T
V
V
T
V
P
G
Y
F
T
L
-------------------------------------------------
P
E
N
S
-
E
G
V
I
L
T
E
I
T
G
G
Q
Y
A
V
A
V
A
R
V
V
G
-
D
--
D
-
F
A
K
P
W
Y
Q
F
-
F
N
-
S
-
L
L
Q
D
S
-
A
Y
-
E
M
---
L
-
P
--
K
P
C
F
-
E
V
Y
L
N
N
G
A
--
E
D
G
Y
W
D
I
E
---
M
Y
V
A
V
Q
P
------------------------------
2
PsiBlast_PDB
46.57
28%
-90
- C5 -
-
3E0H
-
?
A:
[86-157]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
V
T
G
L
T
P
S
G
K
A
A
S
S
L
Y
I
G
P
Y
-
G
--
E
-
I
E
A
V
Y
D
A
L
-
M
--
K
-
W
V
D
D
N
-
G
F
-
D
L
-----
S
--
G
E
A
Y
-
E
I
Y
L
D
N
P
A
E
T
A
P
D
Q
L
R
T
R
---
V
S
L
M
L
H
E
------------------------------
17
PsiBlast_PDB
43.61
42%
-357
* C6 *
-
3I8T
1
LEG4_MOUSE
A:
[94-119]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
W
G
K
E
---------------------
E
K
K
K
S
M
P
F
Q
K
G
K
H
F
E
L
V
F
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
40.79
32%
-103
- C5 -
-
5KAX
3
?
B:
[86-153]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
V
T
G
L
T
P
S
G
K
A
A
S
S
L
Y
I
G
P
Y
-
G
--
E
-
I
E
A
V
Y
D
A
L
-
M
--
K
-
W
V
D
D
N
-
G
F
-
D
L
-----
S
--
G
E
A
Y
-
E
I
Y
L
D
N
P
A
E
T
A
P
D
Q
L
R
T
-----
R
V
S
L
--------------------------------
3
PsiBlast_PDB
40.37
32%
-100
- C5 -
-
5KAX
5
?
A:
[86-153]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
V
T
G
L
T
P
S
G
K
A
A
S
S
L
Y
I
G
P
Y
-
G
--
E
-
I
E
A
V
Y
D
A
L
-
M
--
K
-
W
V
D
D
N
-
G
F
-
D
L
-----
S
--
G
E
A
Y
-
E
I
Y
L
D
N
P
A
E
T
A
P
D
Q
L
R
T
-----
R
V
S
L
--------------------------------
34
HHSearch
39.74
10%
-8
- C5 -
-
3R8J
-
HEBP2_HUMAN
B:
[38-201]
-------------------------------------------------------------
P
G
S
Y
E
I
R
H
Y
G
P
A
K
W
V
S
T
S
V
-
E
S
M
D
W
D
------
S
A
I
Q
T
G
F
T
----
K
L
-----
N
S
Y
I
Q
G
K
N
E
------------------
K
E
-
M
-
K
I
K
---
M
T
--------
A
P
V
T
S
Y
V
E
P
G
---------------------
S
-------
G
P
F
S
E
S
T
I
T
I
S
L
Y
I
P
S
E
Q
Q
F
----------------------------------------------
D
P
P
R
P
L
E
-
S
D
V
F
I
E
D
R
A
E
M
T
V
F
V
R
S
F
D
G
F
S
-
S
AQ
K
-
N
Q
E
Q
L
L
T
L
-
A
--
S
-
I
L
R
E
D
-
G
K
-
V
F
---
D
-
E
--
K
V
Y
Y
-
T
A
G
Y
N
S
P
V
K
--
L
L
N
R
N
N
E
---
V
W
L
I
Q
K
N
------------------------------
4
PsiBlast_PDB
38.73
32%
-48
- C5 -
-
2KCU
-
?
A:
[86-153]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
V
T
G
L
T
P
S
G
K
A
A
S
S
L
Y
I
G
P
Y
-
G
--
E
-
I
E
A
V
Y
D
A
L
-
M
--
K
-
W
V
D
D
N
-
G
F
-
D
L
-----
S
--
G
E
A
Y
-
E
I
Y
L
D
N
P
A
E
T
A
P
D
Q
L
R
T
-----
R
V
S
L
--------------------------------
37
HHSearch
38.70
11%
-16
* C5 *
-
5GQQ
-
HEBP2_HUMAN
B:
[16-177]
-------------------------------------------------------------
P
G
S
Y
E
I
R
H
Y
G
P
A
K
W
V
S
T
S
V
-
E
S
M
D
W
D
------
S
A
I
Q
T
G
F
T
----
K
L
-----
N
S
Y
I
Q
G
K
N
E
------------------
K
E
-
M
K
-
I
K
---
M
T
--------
A
P
V
T
S
Y
V
E
P
G
---------------------
S
-------
G
P
F
S
E
S
T
I
T
I
S
L
Y
I
P
S
E
Q
Q
F
----------------------------------------------
D
P
P
R
P
L
E
-
S
D
V
F
I
E
D
R
A
E
M
T
V
F
V
R
S
F
D
G
F
S
-
S
AQ
K
-
N
Q
E
Q
L
L
T
L
-
A
--
S
-
I
L
R
E
D
-
G
K
-
V
F
---
D
-
E
--
K
V
Y
Y
-
T
A
G
Y
N
S
P
V
K
--
L
L
N
R
N
N
E
---
V
W
L
I
Q
--------------------------------
32
HHSearch
38.43
22%
-10
- C5 -
-
1JYH
-
SBMC_ECOLI
A:
[3-72]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
K
Q
E
E
K
R
T
V
A
G
F
H
L
V
G
P
W
-
E
--
Q
T
V
K
K
G
F
E
Q
L
-
M
--
M
-
W
V
D
S
K
-
N
I
-
V
P
-----
K
---
E
W
V
-
A
V
Y
Y
D
N
P
D
E
T
P
A
E
K
L
R
C
D
---
T
V
V
T
V
P
-------------------------------
39
HHSearch
37.14
11%
-19
- C5 -
-
2HVA
-
HEBP1_MOUSE
A:
[29-189]
--------------------------------------------------------------
V
S
Y
E
E
R
A
C
E
G
G
K
F
A
T
V
E
V
-
T
D
K
P
V
D
------
E
A
L
R
E
A
M
P
----
K
I
-----
M
K
Y
V
G
G
T
N
D
------------------
K
G
-
V
G
-
M
G
---
M
T
--------
V
P
V
S
F
A
V
F
-
P
---------------------
N
------
E
D
G
S
L
Q
K
K
L
K
V
W
F
R
I
P
N
Q
F
Q
----------------------------------------------
G
S
P
P
A
P
S
D
-
E
S
V
K
I
E
E
R
E
G
I
T
V
Y
S
T
Q
F
G
G
Y
A
-
K
E
A
D
-
Y
V
A
H
A
T
Q
L
-
R
--
T
-
T
L
E
G
T
-
P
A
-
T
Y
---
Q
-
G
--
D
V
Y
Y
C
A
G
Y
-
D
P
P
M
K
--
P
Y
G
R
R
N
E
---
V
W
L
V
K
--------------------------------
26
HHSearch
35.40
13%
37
- C5 -
-
3GK6
1
?
A:
[20-170]
--------------------------------------------------------------
Q
G
M
N
I
S
E
I
N
G
F
E
V
T
G
F
V
V
-
R
T
T
N
A
D
E
M
NPMT
A
K
I
G
N
L
W
E
----
K
F
-----
Y
L
N
A
-
A
P
K
L
------------------
T
D
-
K
-----------------
S
K
V
Y
G
L
Y
T
-
N
---------------------
Y
E
-----
S
D
F
T
G
A
F
D
V
I
A
C
S
D
T
L
S
P
Q
-----------------------------------------------------
L
L
-
S
E
S
V
K
T
K
V
S
S
G
K
Y
V
T
F
S
A
T
G
E
M
P
Q
--
V
-
V
I
D
L
W
N
E
V
-
W
--
N
Y
F
A
---C
P
H
-
K
R
---
A
-
Y
--
T
T
D
F
-
E
Y
Y
K
S
A
N
--------
T
V
E
---
I
S
I
A
V
R
-------------------------------
45
Fugue
33.82
19%
69
- C1 -
-
2Y23
4
A:
[6-312]
---------TK
E
V
V
V
N
V
D
DDG
V
I
S
L
N
F
E
C
D
K
M
T
P
K
S
E
F
S
W
S
K
D
--
Y
------------
V
S
T
E
D
S
P
R
-
L
E
V
E
S
K
G
N
K
T
K
M
T
-
F
K
D
L
G
M
------
D
D
L
G
I
Y
S
C
----
D
V
T
DTDG
I
A
S
S
Y
L
I
D
E
------------------
E
E
-
L
K
R
L
L
---
A
L
S
H
E
H
K
F
P
T
V
P
V
K
S
E
L
A
V
E
I
L
EKG
Q
V
R
F
W
M
Q
A
EKLSGN
A
K
V
N
Y
I
F
N
E
K
E
I
F
E
G
P
K
Y
K
M
H
I
D
R
N
T
G
I
I
E
M
F
M
E
K
LQDED
E
G
T
Y
T
F
Q
L
Q
D
G
K
A
T
N
H
-----------------
S
-
T
V
V
L
V
G
D
V
-
F
K
K
L
Q
K
E
A
E
F
Q
R
Q
E
W
I
R
K
Q
G
P
H
-
F
--
V
-
E
Y
L
S
W
E
V
T
-
G
EC
N
-
V
L
L
K
C
-
K
V
-
A
N
---
I
-
K
--
K
E
T
H
-
I
V
W
Y
K
D
E
R
E
I
S
V
D
E
K
H
G
I
---
C
T
L
L
I
T
E
F
SKKDA
G
I
Y
E
V
I
L
KDDR
G
K
D
K
S
R
L
K
L
V
DEA
29
HHSearch
33.63
11%
48
- C5 -
-
5KCB
1
?
A:
[1-157]
--------------------------------------------------------------
M
E
Y
Q
L
Q
Q
L
A
S
L
T
L
V
G
I
K
E
-
T
Y
E
N
G
R
Q
A
Q
---
Q
H
I
A
G
F
W
Q
----
R
C
-----
Y
Q
E
G
V
I
A
D
L
------------------
Q
L
K
N
N
----------------
G
D
L
A
G
I
L
G
-
L
---------------------
C
I
-----
P
E
L
D
G
K
M
S
Y
M
I
A
V
T
G
D
N
S
A
-----------------------------------------------------
D
I
-
A
K
Y
D
V
I
T
L
A
S
S
K
Y
M
V
F
E
A
Q
G
A
V
P
K
--
A
-
V
Q
Q
K
M
E
E
V
-
H
--
H
-
Y
I
H
Q
Y
-
Q
A
N
T
V
---
K
-
S
--
A
P
F
F
-
E
L
Y
Q
D
G
D
T
T
--
S
E
K
Y
I
T
E
---
I
W
M
P
V
K
G
------------------------------
51
Fugue
32.87
8%
41
- C5 -
-
1D5Y
2
ROB_ECOLI
A:
[1-292]
Q
A
G
I
I
R
D
L
L
I
W
L
E
G
H
LDQ
P
L
S
L
DN
V
A
A
K
A
G
Y
S
K
W
H
--
L
Q
R
M
F
K
--
D
V
TGHA
I
G
A
Y
I
R
A
R
R
L
S
K
S
A
V
A
L
R
L
T
A
R
P
I
L
D
I
A
L
Q
Y
R
F
D
S
Q
------
Q
T
F
T
R
A
F
K
----
K
Q
-----
F
A
Q
T
P
A
L
Y
R
R
SPEWSAFGIRPPLRL
G
E
F
T
-
M
P
E
H
K
---
F
V
T
L
E
D
-
T
P
L
I
G
V
T
Q
S
Y
S
C
S
---------------------
L
E
Q
I
S
D
F
R
H
E
M
R
Y
Q
F
W
H
D
F
L
G
N
A
P
T
I
P
P
V
L
Y
G
L
-----------------
N
E
T
R
P
S
QDKDD
E
Q
E
V
F
Y
T
T
A
L
A
-
Q
D
Q
A
D
G
Y
V
-
L
T
G
H
P
V
M
L
Q
G
G
E
Y
V
M
F
T
Y
E
G
L
G
-
T
--
G
-
V
Q
E
F
I
L
T
V
-
Y
--
G
T
C
M
P
M
L
-
N
L
-
T
R
---
R
-
K
--
G
Q
D
I
-
E
R
Y
Y
P
A
E
D
D
R
P
I
N
L
R
C
E
L
L
I
P
I
R
R
K
L
A
A
A
-----------------------------