@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TZS6: (2017-12-17 )
MEKFKLKRRTIMYDGELIKKLRVNKKLTQSQLAEGICFKTSLVGIETNSVKKMSFVTLRSFLERMNMTLAEYEWMRNQLDEPIKLKKKRRMLDRVQEDSFDPYKEISNNRRHFKKTEDLYYLVLNLHMVEKTEVSETEFEFLRYECRIIEEYLMQIPDYGQFELSILADFPWIFSDRFIENNYLKIKKRMRRLAQLNNHEQYLFTFLMNLTSFYIENGRLKKARSVNEDMKRSLAHKERSTVIYETLMADYYQRLISAALGEEKTKDYQEFFTVLEYMLGKNQRRSLEKKLLAIAEPSN
Atome Classification :
(20 SA)
------------------------------------------.........10........20-----------........30...--.--.-...40......-----..50.......-.------60..-...-...-70......-..------80----..--......90........100.-.......110.-.------.-..---..-120---.........-130----------........140.......150---------.....-.-.--.160-.......-----..170..----.--..---..180.--..-.-.-..190...--.-----...200..----.....210....--------...220-.........230.......240-..---......----.250.....-..260-...-.--....270.......280.......290.......-------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------------MEK
F
K
L
KR
R
T
I
MY
D
G
E
L
I
K
K
L
-----------RVNKKL
T
Q
S
Q
L
AE--G--
I
-
C
F
K
T
S
L
V
G
I
ET-----NS
V
K
K
M
S
F
V
T
L
-
R
------
S
F
L
E
-
R
MN-
M
T
L
-
A
E
Y
E
W
M
R
N
-QL------DE----
P
I
--
K
L
K
K
K
R
R
M
L
D
R
V
Q
EDSFD-
P
-
Y
K
E
ISNNRRH
F
-
K
------K-TE---
D
L
-
Y
-----
Y
L
V
L
N
L
H
M
V
-EK-----------TEVSE
T
E
F
E
F
L
R
Y
E
C
R
I
I
E
E
----------
Y
L
M
QI-P-D--YG---
Q
F
E
L
S
I
L-----ADF
P
W
I
F
----S--DR---FIEN
N
Y
--
L
K
-
I
-
K
-
K
R
M
R
R
L
A
Q
--L-----NN
H
E
Q
Y
L
F
----
T
F
L
M
N
L
T
S
F
Y
IE--------NGRL---K
K
A
R
SV
N
E
D
M
K
R
S
L
A
H
K
E
R
S
---
T
V
---
I
Y
E
T
L
M
----
A
D
Y
Y
Q
R
L
I
S
-
A
ALG--
E
E
K
-
T
--
K
D
Y
Q
E
F
F
T
V
L
E
Y
M
LGK
N
Q
R
R
S
L
E
K
K
L
L
AIAEPSN-------------
38
Fugue
67.33
15%
-28
- C5 -
-
4RYK
3
?
A:
[4-303]
------------------------------------------------
H
H
H
S
---
Y
G
E
L
I
R
E
I
-----------
R
L
S
K
G
L
T
Q
K
E
V
Y
T
--
G
--
I
-
I
S
R
S
Y
A
I
G
F
E
K
-----
G
K
-
H
E
I
T
L
S
L
F
-
E
------
E
I
L
K
-
R
I
-M
V
P
L
-
D
E
F
F
F
I
Y
R
-
D
F
------
S
S
----
T
E
--
D
D
S
F
W
I
D
F
V
E
L
S
G
K
N
D
V
V
-
G
M
Q
A
L
L
D
K
I
T
L
E
R
-
T
------
E
-
Q
S
---
E
V
-
R
-----
K
A
I
L
H
T
R
I
Q
-
T
I
-----------
N
H
Y
L
R
T
N
V
S
N
I
S
D
E
Y
K
K
I
I
H
----------
D
Y
L
W
K
M
Q
-
T
--
W
T
---
L
E
E
V
R
I
F
-----
S
N
G
I
S
F
F
-------
E
E
---
E
V
Q
I
H
F
--
Y
Q
-
I
M
L
-
K
S
Y
E
K
Y
R
Y
--
Y
-----
D
R
G
R
L
L
F
C
----
H
L
F
A
N
L
T
D
E
L
I
I
--------
Q
N
K
I
---
N
Y
A
N
L
V
L
E
K
L
K
E
A
S
E
T
S
G
S
F
---
N
S
---
A
F
Y
R
I
V
----
A
N
Y
Y
Q
G
A
I
W
M
K
E
G
E
--
V
E
K
G
Y
--
R
Q
A
K
R
A
I
Q
T
W
K
E
L
H
Y
E
A
I
A
D
L
Y
S
V
V
L
K
Q
F
L
E
K
E
N
IQ-----------
16
HHSearch
64.84
15%
-52
- C5 -
-
4YV6
-
?
B:
[4-261]
------------------------------------------------------
E
L
G
K
T
L
R
R
L
-----------
R
Q
G
K
Q
V
S
I
S
S
L
A
D
--
E
--
H
-
L
S
K
S
Q
I
S
R
F
E
R
-----
G
E
S
E
-
I
S
C
S
R
L
-
L
------
N
L
L
D
-
K
L
N
-
I
T
I
-
D
E
F
V
S
T
H
S
-
K
T
------
H
T
-----
H
--
F
F
T
L
L
S
R
V
R
K
Y
Y
A
E
K
N
V
A
K
L
-
L
K
L
L
E
D
Y
A
H
K
D
-
Y
------
E
------
S
T
-
M
-----
I
K
---
A
I
L
S
-
S
I
-----------
E
P
T
V
----
E
P
S
E
E
E
V
T
R
L
T
D
----------
Y
L
F
S
V
-
E
-
Q
--
W
G
---
Y
Y
E
I
I
L
L
-----
G
N
C
S
R
F
I
----
N
--
Y
N
---
T
L
F
L
L
T
--
K
E
-
M
-
V
-
T
S
F
A
Y
S
E
Q
--
N
-----
K
T
N
K
T
L
V
T
----
Q
L
S
I
N
C
L
I
I
S
I
D
--------
Y
S
Y
F
---
D
H
S
H
Y
L
I
E
K
I
E
F
L
L
R
---
D
E
---
L
N
---
F
Y
E
K
T
V
----
F
L
Y
V
H
G
Y
Y
K
-
L
K
Q
G
--
Q
V
S
-
G
K
-
D
D
M
R
Q
A
L
Q
I
F
K
Y
-
L
G
E
D
A
-----------------------------
15
HHSearch
63.62
15%
-55
- C5 -
-
4YV9
-
?
D:
[4-261]
------------------------------------------------------
E
L
G
K
T
L
R
R
L
-----------
R
Q
G
K
Q
V
S
I
S
S
L
A
D
--
E
--
H
-
L
S
K
S
Q
I
S
R
F
E
R
-----
G
E
S
E
-
I
S
C
S
R
L
-
L
------
N
L
L
D
-
K
L
N
-
I
T
I
-
D
E
F
V
S
T
H
S
----------
T
-----
H
--
F
F
T
L
L
S
R
V
R
K
Y
Y
A
E
K
N
V
A
K
L
-
L
K
L
L
E
D
Y
A
H
K
D
-
Y
------
E
------
S
T
-
M
-----
I
K
---
A
I
L
S
-
S
I
-----------
E
P
T
V
----
E
P
S
E
E
E
V
T
R
L
T
D
----------
Y
L
F
S
V
-
E
-
Q
--
W
G
---
Y
Y
E
I
I
L
L
-----
G
N
C
S
R
F
I
----
N
--
Y
N
---
T
L
F
L
L
T
--
K
E
-
M
-
V
-
T
S
F
A
Y
S
E
Q
--
N
-----
K
T
N
K
T
L
V
T
----
Q
L
S
I
N
C
L
I
I
S
I
D
--------
Y
S
Y
F
---
D
H
S
H
Y
L
I
E
K
I
E
F
L
L
R
---
D
E
---
L
N
---
F
Y
E
K
T
V
----
F
L
Y
V
H
G
Y
Y
K
-
L
K
Q
-----
S
-
G
K-
D
D
M
R
Q
A
L
Q
I
F
K
Y
-
L
G
E
D
A
-----------------------------
21
HHSearch
58.87
17%
-10
- C5 -
-
3U3W
2
?
A:
[3-273]
----------------------------------------------------
A
E
K
L
G
S
E
I
K
K
I
-----------
R
V
L
R
G
L
T
Q
K
Q
L
S
E
--
N
--
I
-
C
H
Q
S
E
V
S
R
I
E
S
-----
G
A
V
Y
-
P
S
M
D
I
L
-
Q
------
G
I
A
A
-
K
L
Q
-
I
P
I
-
I
H
F
Y
E
V
L
I
-
Y
S
------
D
I
----
E
R
--
K
K
Q
F
K
D
Q
V
I
M
L
C
K
Q
K
R
Y
K
E
I
-
Y
N
K
V
W
N
E
L
K
K
E
-
E
------
Y
-
H
P
---
E
F
-
Q
Q
F
L
Q
W
Q
Y
Y
V
A
-
A
Y
V
-
L
K
-----------
K
V
-------
D
Y
E
Y
C
I
L
E
L
K
K
----------
L
L
N
Q
Q
-
L
-
T
GI
D
V
---
Y
Q
N
L
Y
I
E
-----
N
A
I
A
N
I
Y
A
E
N
G
Y
--
L
K
---
K
G
I
D
L
F
--
E
Q
-
I
-
L
-
K
Q
L
E
A
L
H
----------
D
N
E
E
F
D
V
----
K
V
R
Y
N
H
A
K
A
L
Y
L
--------
D
S
R
Y
---
E
E
S
L
Y
Q
V
N
K
A
I
E
I
S
C
---
R
I
---
N
S
---
M
A
L
I
G
Q
----
L
Y
Y
Q
R
G
E
C
L
-
R
K
L
E
--
Y
E
E
A
E
I
E
D
A
Y
K
K
A
S
F
F
F
D
I
-
L
E
M
H
------------------------------
39
Fugue
58.30
13%
-5
- C5 -
-
2QFC
3
?
A:
[3-286]
----------------------------------------------------
A
E
K
L
G
S
E
I
K
K
I
-----------
R
V
L
R
G
L
T
Q
K
Q
L
S
E
--
N
--
I
-
C
H
Q
S
E
V
S
R
I
E
S
-----
G
A
-
V
Y
P
S
M
D
I
L
-
Q
------
G
I
A
A
-
K
L
Q
-
I
P
I
-
I
H
F
Y
E
V
L
I
-
Y
S
------
D
I
----
E
R
--
K
K
Q
F
K
D
Q
V
I
M
L
C
K
Q
K
R
Y
K
-
E
-
I
Y
N
K
V
W
N
E
L
K
K
E
E
------
Y
-
H
P
---
E
F
-
Q
-----
Q
F
L
Q
W
Q
Y
Y
V
-
A
A
-----------
Y
V
L
K
K
V
D
Y
E
Y
C
I
L
E
L
K
K
L
L
N
----------
Q
Q
L
T
G
-
I
-
D
---
V
---
Y
Q
N
L
Y
I
E
-----
N
A
I
A
N
I
Y
----
A
--
E
N
G--
Y
L
K
K
G
I
--
D
L
-
F
-
E
-
Q
I
L
K
Q
L
E
A
--
L
-----
H
D
N
E
E
F
D
V
----
K
V
R
Y
N
H
A
K
A
L
Y
L
--------
D
S
R
Y
---
E
E
S
L
Y
Q
V
N
K
A
I
E
I
S
C
R
I
N
S
M
---------
A
L
I
G
Q
----
L
Y
Y
Q
R
G
E
C
L
-
R
K
L
E
--
Y
E
E
-
A
--
E
I
E
D
A
Y
K
K
A
S
F
F
F
D
I
L
E
M
H
A
Y
K
E
A
L
V
N
K
I
S
R
L
---------------
41
Fugue
56.35
20%
52
- C5 -
-
5JUF
-
?
A:
[1-299]
----------------------------MN
L
K
D
S
I
G
L
R
I
K
T
E
R
E
R
Q
Q
M
S
R
E
V
L
C
L
D
G
A
--------------------
E
L
T
V
R
Q
L
I
R
--
I
--
E
-------
K
G
E
S
L
-----
P
S
L
D
R
L
S
Y
I
A
K
-
R
L
GKS
M
T
E
L
L
D
-
Q
D
N
-
I
T
I
P
D
E
Y
Y
E
M
K
N
-
R
L
I
K
FPTY
R
N
----
P
D
--
R
I
K
S
K
L
T
L
I
E
E
V
Y
E
K
F
F
D
-
I
-
L
P
-------------------
E
E
---
E
L
-
L
-----
T
L
D
I
L
E
N
I
L
-
S
F
-----------
T
S
W
E
E
S
-----
P
K
V
E
E
I
Y
E
D
----------
L
F
E
Q
V
-
K
-
R
--
K
R
---
K
F
S
T
N
D
L
-----
L
V
I
D
Y
Y
F
----
F
--
H
L
---
Y
G
R
K
Q
Y
D
K
K
L
-
F
-
E
-
R
I
I
K
R
V
L
N
--
Q
E
I
W
TD
D
V
Y
N
I
V
L
F
----
N
D
L
M
A
I
A
A
L
K
I
F
--------
H
N
S
F
---
S
D
F
L
T
V
V
D
K
A
L
A
V
I
E
K
S
Q
----------
L
Y
S
Y
K
P
----
S
V
F
V
L
K
A
K
Y
-
E
L
L
H
--
K
E
N
-
K
--
K
E
A
A
E
N
Y
D
K
A
I
V
F
A
S
V
L
E
D
S
V
L
E
E
S
I
K
A
G
K
L
A
D
G
L------------
20
HHSearch
55.07
17%
-6
- C5 -
-
2QFC
1
?
B:
[3-274]
----------------------------------------------------
A
E
K
L
G
S
E
I
K
K
I
-----------
R
V
L
R
G
L
T
Q
K
Q
L
S
E
--
N
--
I
-
C
H
Q
S
E
V
S
R
I
E
S
-----
G
A
V
Y
-
P
S
M
D
I
L
-
Q
------
G
I
A
A
-
K
L
Q
-
I
P
I
-
I
H
F
Y
E
V
L
I
-
Y
S
------
D
I
----
E
R
--
K
K
Q
F
K
D
Q
V
I
M
L
C
K
Q
K
R
Y
K
E
I
-
Y
N
K
V
W
N
E
L
K
K
E
-
E
------
Y
-
H
P
---
E
F
-
Q
QFLQW
Q
Y
Y
V
A
-
A
Y
V
-
L
K
-----------
K
V
-------
D
Y
E
Y
C
I
L
E
L
K
K
----------
L
L
N
Q
Q
-
L
-
T
GI
D
V
---
Y
Q
N
L
Y
I
E
-----
N
A
I
A
N
I
Y
AENG
Y
--
L
K
---
K
G
I
D
L
F
--
E
Q
-
I
-
L
-
K
Q
L
E
A
L
H
----------
D
N
E
E
F
D
V
----
K
V
R
Y
N
H
A
K
A
L
Y
L
--------
D
S
R
Y
---
E
E
S
L
Y
Q
V
N
K
A
I
E
I
S
C
---
R
I
---
N
S
---
M
A
L
I
G
Q
----
L
Y
Y
Q
R
G
E
C
L
-
R
K
L
E
--
Y
E
E
A
E
IE
D
A
Y
K
K
A
S
F
F
F
D
I
-
L
E
M
H
A
-----------------------------
3
PsiBlast_PDB
54.49
29%
-174
- C5 -
-
4RYK
1
?
A:
[11-70]
--------------------------------------------------------
G
E
L
I
R
E
I
-----------
R
L
S
K
G
L
T
Q
K
E
V
Y
T
--
G
--
I
-
I
S
R
S
Y
A
I
G
F
E
K
-----
G
K
-
H
E
I
T
L
S
L
F
-
E
------
E
I
L
K
-
R
I
M
-
V
P
L
-
D
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
54.23
13%
-13
- C5 -
-
2GRM
-
?
A:
[1-271]
----------------------------------------------------
M
F
K
I
G
S
V
L
K
Q
I
-----------
R
Q
E
L
N
Y
H
Q
I
D
L
Y
S
--
G
--
I
-
M
S
K
S
V
Y
I
K
V
E
A
-----
D
S
R
P
-
I
S
V
E
E
L
-
S
------
K
F
S
E
-
R
L
G
-
V
N
F
-
F
E
I
L
N
R
A
G
-
M
N
------
T
K
----
S
V
N
E
T
G
K
E
K
L
L
I
S
K
I
F
T
N
P
D
L
--
F
-
D
K
N
F
Q
R
I
E
P
K
R
-
L
------
T
-
S
L
---
Q
Y
-
F
-----
S
I
Y
L
G
Y
I
S
I
-
A
H
-----------
H
Y
N
I
E
-
V
P
T
F
N
K
T
I
T
S
D
L
K
H
----------
L
Y
D
K
R
-
T
-
T
--
F
F
---
G
I
D
Y
E
I
V
-----
S
N
L
L
N
V
L
----
P
--
Y
E
---
E
V
S
S
I
I
--
K
P
-
M
-
Y
-
P
I
V
D
S
F
G
K
---------
D
Y
D
L
T
I
Q
----
T
V
L
K
N
A
L
T
I
S
I
M
--------
N
R
N
L
---
K
E
A
Q
Y
Y
I
N
Q
F
E
H
L
K
T
---
I
K
NIS
I
N
---
G
C
Y
D
L
E
----
I
N
Y
L
K
Q
I
Y
Q
-
F
L
T
D
--
K
N
I
-
D
S
Y
L
N
A
V
N
I
I
N
I
F
K
I
-
I
G
K
E
D
-----------------------------
37
Fugue
53.74
13%
22
- C5 -
-
2AWI
-
?
A:
[2-301]
-----------------------------------------------------
F
K
I
G
S
V
L
K
Q
I
-----------
R
Q
E
L
N
Y
H
Q
I
D
L
Y
S
--
G
--
I
M
S
-
K
S
V
Y
I
K
V
E
A
-----
D
S
R
P
I
-
S
V
E
E
L
-
S
------
K
F
S
E
-
R
L
G
-
V
N
F
-
F
E
I
L
N
R
A
G
M
N
S
------
V
N
----
E
T
--
G
K
E
K
L
L
I
S
K
I
F
T
N
P
D
L
F
D
-
K
-
N
F
Q
R
I
E
P
K
R
L
T
-
S
------
L
-
Q
Y
---
F
S
-
I
-----
Y
L
G
Y
I
S
I
A
H
-
H
Y
--------------
N
I
E
V
P
T
F
N
K
T
I
T
S
D
L
K
H
----------
L
Y
D
K
R
-
T
-
T
--
F
F
---
G
I
D
C
E
I
V
-----
S
N
L
L
N
V
L
----
P
--
Y
E
---
E
V
S
S
I
I
--
K
P
M
Y
-
P
-
I
V
----
D
S
--
F
-----
G
K
D
Y
D
L
T
I
----
Q
T
V
L
K
N
A
L
T
I
S
I
M
-------
N
R
N
L
---
K
E
A
Q
Y
Y
I
N
Q
F
E
H
L
K
T
I
K
N
I
S
---
I
N
---
G
Y
Y
D
L
E
----
I
N
Y
L
K
Q
I
Y
Q
-
F
L
T
D
KN
I
D
S
-
Y
--
L
N
A
V
N
I
I
N
I
F
K
I
I
G
K
E
D
I
H
R
S
L
V
E
E
L
T
K
I
S
A
K
E
K
FTPP
K
E
V
T
M
Y
Y
E
N
46
Fugue
52.59
15%
-11
- C3 -
-
5L3X
-
NELFD_HUMAN
B:
[1-405]
G
E
I
T
S
V
S
T
A
C
QQ
L
E
V
F
S
R
V
L
R
T
S
L
A
T
I
L
D
G
GEEN
L
E
K
N
L
P
E
F
A
K
M
V
C
H
G
E
H
T
Y
L
F
A
Q
A
M
M
S
V
L
A
Q
EEQG
G
S
A
V
R
R
I
A
Q
E
V
Q
R
F
A
Q
E
K
--
G
--
H
-
D
A
S
Q
I
T
L
A
L
G
T
-----
A
A
S
Y
P
R
A
C
Q
A
L
-
G
------
A
M
L
S
-
K
G
A
-
L
N
P
-
A
D
I
T
V
L
F
K
-
M
F
------
T
S
MDPP
P
V
--
E
L
I
R
V
P
A
F
L
D
L
F
M
Q
S
L
F
K
-
P
-
G
A
R
I
N
Q
D
H
-----------
K
-
H
K
---
Y
I
-
H
-----
I
L
A
Y
A
A
S
V
V
-
E
T
W
K
KNKRVSINK
D
E
L
K
S
T
S
K
A
V
E
T
V
H
N
L
C
C
N
E
NASELVAE
L
S
T
L
Y
Q
C
-
I
-
R
--
F
P
---
V
V
A
M
G
V
L
-----
K
W
V
D
W
T
V
----
S
---------
E
P
R
Y
--
F
Q
-
L
-
Q
P
V
H
L
A
L
L
D
E
--
I
-----
S
T
C
H
Q
L
L
H
----
P
Q
V
L
Q
L
L
V
K
L
F
E
TEHSALD
V
M
E
Q
L
---
E
L
K
K
T
L
L
D
R
M
V
H
L
L
S
R
G
Y
V
L
---
P
V
V
S
Y
I
R
K
C
L
E
KDTD
I
S
L
I
R
Y
F
V
T
-
E
V
L
D
--
V
I
A
-
P
--
P
Y
T
S
D
F
V
Q
L
F
L
P
I
L
E
N
D
S
I
A
D
P
V
T
E
F
I
A
H
C
K
S
N
F
I
M
V
N---------
43
Fugue
49.83
19%
48
- C1 -
-
5MSN
-
DCC1_YEAST
A:
[27-293]
------------------------------------------
H
G
E
L
N
L
N
S
-
V
P
I
Y
N
G
E
L
D
F
S
D
-----------
K
I
K
V
I
G
T
L
E
E
L
L
E
--
N
--
S
-
P
C
-
S
A
L
E
G
I
S
K
W
H
K
I
G
G
S
V
K
D
G
V
L
C
I
L
S
Q
------
D
F
L
F
-
K
A
L
-
H
V
L
-
L
M
S
A
M
A
E
S
-
L
D
------
L
Q
----
H
L
--
N
V
E
D
T
H
H
A
V
G
K
D
I
E
D
E
F
N
-
P
-
Y
--------------------
T
R
---
E
I
-
I
-----
E
T
V
L
N
K
F
A
V
-
Q
E
-----------
Q
E
N
N
T
W
R
L
R
I
P
F
I
A
Q
W
Y
G
I
Q
----------
A
L
R
K
Y
-
V
-
S
--
G
I
---
S
M
P
---
I
-----
D
E
F
L
I
K
W
----
K
--
S
L
---
F
P
P
F
F
P
--
C
D
-
I
-
D
-
I
D
M
L
R
G
Y
H
--
F
-----
K
P
T
D
K
-------------
T
V
Q
Y
I
A
--------
K
S
T
L
---
P
M
D
------------
P
K
E
R
F
---
K
V
---
L
F
R
L
-
Q
----
S
Q
W
D
L
E
D
I
K
-
P
L
I
E
--
E
L
N
-
S
--
R
G
M
K
----
I
D
S
F
I
M
K
Y
A
R
R
K
R
L
G
K
K
T
V
V
T
S
R
----------------
22
HHSearch
44.56
13%
-
- C5 -
-
5DL2
-
?
B:
[58-263]
----------------------------------------------------------------------------------------------------------------------------------------------
D
E
F
L
F
I
S
N
-
N
F
------
K
Q
----
Y
K
--
E
F
I
D
M
D
T
A
K
H
Y
F
E
C
R
N
I
E
G
L
-
N
H
I
L
D
S
Y
K
D
S
K
-
S
------
T
-
K
E
---
K
N
-
L
-----
F
A
L
V
K
V
L
L
A
-
T
L
--------------
T
E
E
---
D
C
L
T
E
R
T
Y
L
S
N
----------
Y
L
I
N
I
-
E
-
T
--
W
S
---
H
Y
E
T
V
L
F
-----
N
N
C
M
F
I
F
----
E
--
S
C
---
F
I
E
M
V
F
--
S
K
-
V
-
I
-
L
N
L
D
K
Y
N
T
--
L
------
Y
Y
G
N
E
S
I
----
R
M
F
V
N
M
L
I
L
F
I
Q
--------
R
Q
E
Y
---
D
K
A
S
E
I
L
A
K
I
E
D
Y
Q
L
---
N
D
---
D
C
---
L
Y
E
R
C
C
----
V
S
F
F
D
G
I
I
G
-
L
I
N
G
--
K
E
G
-
A
E-
Q
K
C
V
Q
I
L
E
I
F
Q
L
-
L
N
C
K
T
-----------------------------
18
HHSearch
44.33
14%
35
- C5 -
-
5JUF
-
?
A:
[1-284]
-------------------------------------------------
M
N
L
K
D
S
I
G
L
R
I
K
T
E
-----------
R
E
R
Q
Q
M
S
R
E
V
L
C
L
--
D
GA
E
-
L
T
V
R
Q
L
I
R
I
E
K
-----
G
E
S
L
-
P
S
L
D
R
L
-
S
------
Y
I
A
K
-
R
L
G
-
K
S
M
-
T
E
L
L
D
Q
D
N
-
I
T
------
I
P
----
D
E
--
Y
Y
E
M
K
N
R
L
I
K
F
P
T
Y
R
N
P
D
R
I
-
K
S
K
L
T
L
I
E
E
V
Y
-
E
K
F
FDIL
P
-
E
E
E
--
L
L
T
L
-----
D
I
L
E
N
I
L
S
F
-
T
S
-----------
W
E
-------
E
S
P
K
V
E
E
I
Y
E
D
L
F
E
-------
Q
V
K
R
K
-
R
-
K
--
F
S
---
T
N
D
L
L
V
I
-----
D
Y
Y
F
F
H
L
----
Y
GR
K
Q
---
Y
D
K
K
L
F
--
E
R
-
I
-
I
-
K
R
V
L
N
Q
E
I
W
T
D
-----
D
V
Y
N
I
V
L
F
----
N
D
L
M
A
I
A
A
L
K
I
F
--------
H
N
S
F
---
S
D
F
L
T
V
V
D
K
A
L
A
V
I
E
---
K
S
---
Q
L
---
Y
S
Y
K
P
S
----
V
F
V
L
K
A
K
Y
E
L
L
H
K
E
--
N
K
K
-
E
A
A
E
N
Y
D
K
A
I
V
F
A
S
V
-
L
E
D
S
------------------------------
19
HHSearch
37.70
12%
42
- C5 -
-
5FD4
-
?
A:
[19-311]
-------------------------------------------
S
H
M
E
V
W
F
M
N
D
K
E
F
G
Q
R
V
R
Q
L
-----------
R
E
S
A
S
M
T
R
E
Q
F
C
D
DE
L
--
E
-
L
S
V
R
Q
L
T
R
I
E
A
-----
G
A
S
K
-
P
T
F
S
K
I
-
Q
------
Y
I
A
T
-
R
L
G
-
M
G
L
-
Y
E
L
M
P
D
Y
V
-
S
L
------
P
E
-----
R
--
Y
S
K
L
K
F
D
V
L
R
T
P
T
Y
G
N
E
D
L
A
-
E
K
R
D
A
M
M
T
E
I
Y
-
D
DYY---
D
E
L
P
E
E
E
K
I
-
A
-----
I
D
A
I
Q
S
R
I
D
-
T
L
--------------
E
S
---
G
T
A
G
F
G
K
E
I
L
E
D
----------
Y
F
E
Q
I
-
F
-
R
--
K
R
KYE
L
N
D
L
L
I
V
R
L
H
L
E
Y
V
R
L
S
S
C
----
D
--
S
E
I
F
R
Q
F
L
K
I
I
--
E
H
-
L
-
H
-
E
Q
I
N
I
I
N
---------
S
N
D
L
F
V
L
R
----
D
T
L
L
S
C
V
N
I
L
G
S
--------
K
K
Y
Y
---
E
P
I
P
K
I
F
D
S
V
D
K
I
I
Q
---
S
T
---
Q
D
---
F
Q
K
K
P
I
----
V
S
V
L
K
W
K
Y
A
L
F
V
D
K
--
D
R
D
-
E
A
E
K
H
Y
L
D
A
V
L
F
A
K
L
-
I
E
N
R
E
L
----------------------------
28
HHSearch
35.56
24%
-18
- C5 -
-
4I6R
4
?
A:
[6-75]
-------------------------------------------------
S
F
L
L
S
K
V
S
F
V
I
K
K
I
-----------
R
L
E
K
G
M
T
Q
E
D
L
A
Y
--
K
--
S
N
L
D
R
T
Y
I
S
G
I
E
R
-----
N
S
R
N
-
L
T
I
K
S
L
-
E
------
L
I
M
K
-
G
L
E
-
V
S
D
-
V
V
F
F
E
M
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
35.33
18%
-102
* C5 *
-
3DNV
1
HIPB_ECOLI
B:
[4-74]
----------------------------------------------
F
Q
K
I
Y
S
P
T
Q
L
A
N
A
M
K
L
V
-----------
R
Q
Q
N
G
W
T
Q
S
E
L
A
K
--
K
--
I
-
G
I
K
Q
A
T
I
S
N
F
E
-----
N
N
P
D
N
T
T
L
T
T
F
-
F
------
K
I
L
Q
-
S
L
E
-
L
S
M
-
T
L
C
D
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
35.02
17%
-4
- C2 -
-
5TPI
-
?
A:
[7-211]
----------------------------------------------------------------------------------------------------------------
Q
G
L
F
S
L
G
S
L
-
E
------
S
T
A
A
V
R
I
P
-
S
T
L
-
A
H
F
N
Q
R
Y
P
-
K
I
------
H
L
----
A
L
--
S
T
G
P
S
G
T
M
I
D
G
V
L
E
G
A
-------------------------------------------
L
S
A
A
F
V
-
D
------------
G
P
L
V
H
P
G
L
E
G
L
P
----
V
F
P
E
----------
E
M
M
I
V
-
A
-
P
--
Y
G
---
H
A
P
I
T
---------------------------------------------
R
A
S
E
--
V
-----
N
G
A
N
V
Y
A
F
RAN
C
S
Y
R
R
H
F
E
S
W
F
H
A
--------
D
R
A
T
---
P
G
R
I
H
E
M
E
S
Y
H
G
M
L
A
C
V
I
A
G
A
G
L
A
L
---
I
P
R
S
M
L
----
E
S
M
P
G
H
Q
Q
V
-
S
A
W
P
--
L
A
E
-
E
--
W
R
W
L
T
T
W
L
V
W
R
R
---
G
A
K
T
R
Q
L
E
A
F
I
A
L
L
N
E
D
R
Q
TVVSP--------
40
Fugue
34.80
15%
44
* C3 *
-
5L0W
-
?
B:
[5-213]
-------------------------------------------
D
T
F
T
F
I
P
L
H
I
D
P
K
--------------------
S
K
A
I
S
A
A
P
N
A
L
--
G
--------------------------
T
P
S
A
N
-
K
------
A
L
E
T
-
E
L
A
-
A
L
N
-
A
L
H
R
A
L
H
T
-
Q
I
------
E
G
----
P
I
--
P
V
P
P
P
P
V
P
V
N
P
K
R
S
A
N
I
N
-
K
-
L
R
E
S
G
N
A
E
Y
R
K
-
Q
------
R
-
Y
G
---
D
A
-
I
-----
K
L
-
Y
T
L
G
L
Q
M
A
L
-----------
T
R
P
A
W
E
P
A
G
L
V
R
D
E
I
H
Q
L
Y
S
----------
N
R
A
Q
A
-
Y
M
Q
--
L
G
---
Q
-----------------------------------
W
--
P
E
-
A
-
A
-
A
D
A
E
C
S
V
E
--
A
-----
K
R
Q
G
------------
N
A
K
A
W
Y
R
R
--------
G
K
C
L
M
E
M
R
R
L
Q
E
A
R
E
W
V
A
R
G
L
E
F
E
G
E
-----------
E
K
E
L
----
A
E
L
L
K
E
I
D
S
-
K
L
A
A
--
E
K
A
-
S
--
R
D
---------------------------------------------
33
HHSearch
34.33
24%
-6
- C5 -
-
4IA8
-
?
B:
[6-76]
-------------------------------------------------
S
F
L
L
S
K
V
S
F
V
I
K
K
I
-----------
R
L
E
K
G
M
T
Q
E
D
L
A
Y
--
K
--
S
N
L
D
R
T
A
I
S
G
I
E
R
-----
N
S
R
N
-
L
T
I
K
S
L
-
E
------
L
I
M
K
-
G
L
E
-
V
S
D
-
V
V
F
F
E
M
L
I
-
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------