@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U0T7: (2017-12-18 )
MFIMKRIGILTSGGDAPGMNAAVRAVVRKGIYEGLEVYGINYGFAGLVAGDIRRLDVADVGDKIQRGGTFLYSARYPEFATEEGQLKGIEQLKKFGIEGLVVIGGDGSYHGAMALTKRGFPAVGIPGTIDNDIPGTDFTIGFDTAINTVLESIDRIRDTATSHVRTFVIEVMGRNAGDIALWSGVAGGADEIIIPEHDFDMASVAKKIQEGRDRGKKHCLIILAEGVMGGNEFAEKLSEFGDYHTRVSILGHVVRGGAPSARDRVLASKFGAYAVELLQEGKGGLCVGIHDNEIVASDIIDTLENNKHKPDLSLYDLNNSLSF
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210........220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MF
I
M
K
RI
G
I
L
TSGGDAP
G
M
N
A
A
V
R
A
V
V
R
K
G
I
Y
EG
L
E
V
YGINYG
F
A
G
L
V
AGD
I
R
RL
D
V
A
D
V
G
D
K
I
QRG
G
T
F
L
Y
SARYPEFATEEG
Q
L
K
G
I
E
Q
L
K
K
FGI
E
G
L
V
V
IGGDGSYH
G
A
M
A
L
T
KRGFPAVGIPGTIDNDIPGT
D
F
T
I
G
F
D
T
A
I
N
T
V
L
E
S
I
D
R
I
R
D
T
A
T
S
H
V
R
T
F
V
I
E
V
MGRNAG
D
I
A
L
WSGVAGGAD
E
I
I
IPEHDF
D
M
A
S
V
A
K
K
I
Q
E
-
G
R
DRGK
K
H
C
L
I
I
L
A
E
G
VMG
G
N
E
F
A
E
K
L
S
E
FG
D
Y
H
T
R
V
S
I
L
G
H
V
V
RGGAP
S
A
R
D
R
V
L
A
S
K
F
G
A
Y
A
V
E
L
L
QEGKG
G
L
C
V
G
IHDN
E
I
V
A
S
D
I
I
D
T
L
ENNKHKPD
L
S
L
Y
DLNNSLSF
23
PsiBlast_CBE
94.24
67%
-109
- C5 -
-
6PFK
2
PFKA_GEOSE
B:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
1
PsiBlast_PDB
93.78
67%
-112
- C5 -
-
6PFK
2
PFKA_GEOSE
A:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
4
PsiBlast_PDB
93.72
66%
-116
- C5 -
-
4PFK
3
PFKA_GEOSE
A:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
Q
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
21
PsiBlast_CBE
93.36
67%
-112
- C5 -
-
6PFK
2
PFKA_GEOSE
D:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
29
PsiBlast_CBE
93.19
66%
-114
- C5 -
-
4I4I
2
PFKA_GEOSE
B:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
A
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
3
PsiBlast_PDB
93.19
66%
-116
- C5 -
-
3PFK
-
PFKA_GEOSE
A:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
Q
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
22
PsiBlast_CBE
93.15
67%
-115
- C5 -
-
6PFK
2
PFKA_GEOSE
C:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
27
PsiBlast_CBE
92.90
66%
-115
- C5 -
-
4I4I
2
PFKA_GEOSE
D:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
A
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
7
PsiBlast_PDB
92.51
66%
-111
- C5 -
-
4I7E
2
PFKA_GEOSE
A:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
A
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
6
PsiBlast_PDB
92.44
66%
-114
- C- -
-
4I36
-
PFKA_GEOSE
A:
[1-318]
---
M
K
R
I
G
V
L
T
S
G
G
A
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
-
5
PsiBlast_PDB
92.40
66%
-109
- C5 -
-
4I4I
2
PFKA_GEOSE
A:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
A
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
28
PsiBlast_CBE
92.19
66%
-113
- C5 -
-
4I4I
2
PFKA_GEOSE
C:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
A
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
30
PsiBlast_CBE
92.14
66%
-112
- C5 -
-
4I7E
2
PFKA_GEOSE
D:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
A
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
10
PsiBlast_PDB
92.08
60%
-119
- C5 -
-
1ZXX
-
PFKA_LACDE
A:
[1-318]
---
M
K
R
I
G
I
L
T
S
G
G
D
A
P
G
M
N
A
A
V
R
A
V
T
R
V
A
I
A
N
G
L
E
V
F
G
I
R
Y
G
F
A
G
L
V
A
G
D
I
F
P
L
E
S
E
D
V
A
H
L
I
N
V
S
G
T
F
L
Y
S
A
R
Y
P
E
F
A
E
E
E
G
Q
L
A
G
I
E
Q
L
K
K
H
G
I
D
A
V
V
V
I
G
G
D
G
S
Y
H
G
A
L
Q
L
T
R
H
G
F
N
S
I
G
L
P
G
T
I
D
N
D
I
P
Y
T
D
A
T
I
G
Y
D
T
A
C
M
T
A
M
D
A
I
D
K
I
R
D
T
A
S
S
H
H
R
V
F
I
V
N
V
M
G
R
N
C
G
D
I
A
M
R
V
G
V
A
C
G
A
D
A
I
V
I
P
E
R
P
Y
D
V
E
E
I
A
N
R
L
K
Q
-
A
Q
E
S
G
K
D
H
G
L
V
V
V
A
E
G
V
M
T
A
D
Q
F
M
A
E
L
K
K
Y
G
D
F
D
V
R
A
N
V
L
G
H
M
Q
R
G
G
T
P
T
V
S
D
R
V
L
A
S
K
L
G
S
E
A
V
H
L
L
L
E
G
K
G
G
L
A
V
G
I
E
N
G
K
V
T
S
H
D
I
L
D
-
L
F
D
E
S
H
R
G
D
Y
D
L
L
K
L
N
A
D
L
S
-
31
PsiBlast_CBE
92.04
66%
-112
- C5 -
-
4I7E
2
PFKA_GEOSE
C:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
A
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
32
PsiBlast_CBE
92.03
66%
-108
- C5 -
-
4I7E
2
PFKA_GEOSE
B:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
A
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
2
PsiBlast_PDB
91.96
67%
-114
- C5 -
-
3U39
-
PFKA_GEOSE
A:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
39
PsiBlast_CBE
91.76
66%
-113
- C5 -
-
1MTO
3
PFKA_GEOSE
B:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
W
V
I
E
V
M
G
R
H
A
G
D
I
A
L
Y
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
8
PsiBlast_PDB
91.66
66%
-115
- C5 -
-
1MTO
2
PFKA_GEOSE
A:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
W
V
I
E
V
M
G
R
H
A
G
D
I
A
L
Y
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
37
PsiBlast_CBE
91.35
66%
-114
- C5 -
-
1MTO
2
PFKA_GEOSE
D:
[1-319]
---
M
K
R
I
G
V
L
T
S
G
G
D
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
W
V
I
E
V
M
G
R
H
A
G
D
I
A
L
Y
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
-
G
H
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
-
N
K
H
T
I
D
Q
R
M
Y
A
L
S
K
E
L
S
I
81
HHSearch
88.34
67%
-79
- C5 -
-
4I7E
2
PFKA_GEOSE
C:
[1-318]
---
M
K
R
I
G
V
L
T
S
G
G
A
S
P
G
M
N
A
A
I
R
S
V
V
R
K
A
I
Y
H
G
V
E
V
Y
G
V
Y
H
G
Y
A
G
L
I
A
G
N
I
K
K
L
E
V
G
D
V
G
D
I
I
H
R
G
G
T
I
L
Y
T
A
R
C
P
E
F
K
T
E
E
G
Q
K
K
G
I
E
Q
L
K
K
H
G
I
E
G
L
V
V
I
G
G
D
G
S
Y
Q
G
A
K
K
L
T
E
H
G
F
P
C
V
G
V
P
G
T
I
D
N
D
I
P
G
T
D
F
T
I
G
F
D
T
A
L
N
T
V
I
D
A
I
D
K
I
R
D
T
A
T
S
H
E
R
T
Y
V
I
E
V
M
G
R
H
A
G
D
I
A
L
W
S
G
L
A
G
G
A
E
T
I
L
I
P
E
A
D
Y
D
M
N
D
V
I
A
R
L
K
R
G
H
-
E
R
G
K
K
H
S
I
I
I
V
A
E
G
V
G
S
G
V
D
F
G
R
Q
I
Q
E
A
T
G
F
E
T
R
V
T
V
L
G
H
V
Q
R
G
G
S
P
T
A
F
D
R
V
L
A
S
R
L
G
A
R
A
V
E
L
L
L
E
G
K
G
G
R
C
V
G
I
Q
N
N
Q
L
V
D
H
D
I
A
E
A
L
A
N
K
H
T
-
I
D
Q
R
M
Y
A
L
S
K
E
L
S
-