@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U0W2: (2017-12-18 )
MVPKKQVKEGTKMSRPNLQIALDHNDLEHALGDVMKVGDVVDIIEVGTILCLQEGQKAIRCIRSMFPDKKLVADTKCADAGGTVASNVAKAGADWMTVICCATIPTMEAAQKEIGELQVELYGNWTFEQAMDWHNIGIRQVIYHQSRDALLSGETWGEKDLSKIKKLIELGFNVSVTGGLNPHTLHLFEGIDVYTFITGRGITAANDPMKAAQNFKDEIIRIWG
Atome Classification :
(34 SA)
.........10........20........30........40........50........60........70........80........90........100....----...----110---..---.-------.....120.......130.......140.......150.......160.......170.......180.......190...--....200.......210.......220..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MV
P
K
K
Q
V
KEGTKMSRP
N
L
Q
I
A
LDHN
D
L
E
H
A
L
G
D
V
M
K
VG
D
V
V
D
I
I
E
V
G
T
I
L
C
L
Q
E
G
Q
K
A
I
R
C
I
R
S
MFPDKKLVADTKCADAGG
T
V
A
S
N
V
A
KAGA
D
W
M
T
V
I
C
CATIP
T
----
M
E
A
----
A
Q
----
K
E
---
I
-------
G
E
L
Q
V
E
L
Y
GN
W
T
F
E
Q
A
M
D
W
H
NI
G
I
R
Q
V
I
Y
HQSRDALLSGETW
G
E
K
D
L
S
K
I
K
K
L
I
E
LGF
N
V
S
VTGGLNP
H
T
L
H
L
FEG
I
D
V
Y
T
--
F
I
TGRGITAAN
D
P
M
K
A
A
Q
N
F
K
D
E
I
I
R
IWG
21
PsiBlast_CBE
88.78
64%
-57
- C2 -
-
3EXS
1
?
D:
[6-221]
---------------
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
----
M
K
A
----
A
R
----
K
A
---
I
EDINPDK
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
D
A
L
L
A
G
E
T
W
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
E
G
V
D
V
F
T
--
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
23
PsiBlast_CBE
84.16
64%
-47
- C2 -
-
3EXS
1
?
B:
[6-221]
---------------
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
----
M
K
A
----
A
R
----
K
A
---
I
E
D
I
NPD
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
-------
T
W
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
E
G
V
D
V
F
T
--
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
2
PsiBlast_PDB
83.82
64%
-42
- C2 -
-
3EXS
1
?
A:
[6-221]
---------------
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
----
M
K
A
----
A
R
----
K
A
---
I
E
D
I
N
PD
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
---------
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
E
G
V
D
V
F
T
--
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
1
PsiBlast_PDB
83.71
64%
-
- C2 -
-
3EXR
-
?
A:
[6-221]
---------------
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
----
M
K
A
----
A
R
----
K
A
---
I
E
D
I
N
PD
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
D
A
L
L
A
G
E
T
W
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
E
G
V
D
V
F
T
--
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
3
PsiBlast_PDB
83.41
64%
-46
- C2 -
-
3EXT
-
?
A:
[6-221]
---------------
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
----
M
K
A
----
A
R
----
K
A
---
I
E
D
I
N
PD
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
-------
T
W
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
E
G
V
D
V
F
T
--
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
22
PsiBlast_CBE
82.86
64%
-44
- C2 -
-
3EXS
1
?
C:
[6-221]
---------------
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
----
M
K
A
----
A
R
----
K
A
---
I
E
D
I
N
PD
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
---------
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
E
G
V
D
V
F
T
--
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
88
HHSearch
82.17
63%
-
- C2 -
-
3EXR
-
?
A:
[3-221]
------------
K
Q
L
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
----
M
K
A
----
A
R
K
A
I
E
D
I
N
PD
K
-------
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
D
A
L
L
A
G
E
T
W
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
--
E
G
V
D
V
F
T
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
108
HHSearch
81.00
47%
-70
- C2 -
-
1XBZ
2
ULAD_ECOLI
B:
[1-216]
------------
M
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
----
A
K
G
A
L
D
V
A
K
----
E
F
---
N
-------
G
D
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
V
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
36
PsiBlast_CBE
80.96
45%
-73
- C2 -
-
1XBZ
2
ULAD_ECOLI
B:
[1-216]
------------
M
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
V
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
29
PsiBlast_CBE
80.80
47%
-68
- C2 -
-
1KW1
2
ULAD_ECOLI
B:
[2-216]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
25
PsiBlast_CBE
80.61
47%
-69
- C2 -
-
1Q6R
2
ULAD_ECOLI
B:
[2-216]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
AKGA
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
26
PsiBlast_CBE
80.48
47%
-71
- C2 -
-
1Q6Q
2
ULAD_ECOLI
B:
[2-215]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
10
PsiBlast_PDB
80.26
47%
-67
- C2 -
-
1XBV
2
ULAD_ECOLI
A:
[3-215]
--------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
27
PsiBlast_CBE
80.18
47%
-68
- C2 -
-
1Q6O
2
ULAD_ECOLI
B:
[2-216]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
24
PsiBlast_CBE
80.05
47%
-66
- C2 -
-
1XBV
2
ULAD_ECOLI
B:
[2-216]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
6
PsiBlast_PDB
80.01
47%
-65
- C2 -
-
1Q6L
2
ULAD_ECOLI
A:
[2-215]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
35
PsiBlast_CBE
79.97
46%
-70
- C2 -
-
1SO6
2
ULAD_ECOLI
B:
[2-216]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
AKGA
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
Q
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
A
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
32
PsiBlast_CBE
79.87
46%
-73
- C2 -
-
1SO4
2
ULAD_ECOLI
B:
[2-216]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
A
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
9
PsiBlast_PDB
79.83
47%
-66
- C2 -
-
1Q6R
2
ULAD_ECOLI
A:
[2-215]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
34
PsiBlast_CBE
79.78
46%
-72
- C2 -
-
1SO3
2
ULAD_ECOLI
B:
[2-216]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
AKGA
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
A
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
31
PsiBlast_CBE
79.73
46%
-66
- C2 -
-
1SO5
2
ULAD_ECOLI
B:
[2-216]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
Q
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
33
PsiBlast_CBE
79.65
46%
-69
- C2 -
-
1XBY
2
ULAD_ECOLI
B:
[2-216]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
15
PsiBlast_PDB
79.33
46%
-69
- C2 -
-
1SO6
2
ULAD_ECOLI
A:
[2-216]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
Q
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
A
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
12
PsiBlast_PDB
79.29
46%
-72
- C2 -
-
1SO4
2
ULAD_ECOLI
A:
[3-215]
--------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
A
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
14
PsiBlast_PDB
79.26
46%
-69
- C2 -
-
1SO3
2
ULAD_ECOLI
A:
[2-215]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
A
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
37
PsiBlast_CBE
79.14
45%
-73
- C2 -
-
1XBX
2
ULAD_ECOLI
B:
[2-216]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
V
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
28
PsiBlast_CBE
78.72
47%
-68
- C2 -
-
1Q6L
2
ULAD_ECOLI
B:
[2-216]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
AKGA
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
13
PsiBlast_PDB
78.57
46%
-67
- C2 -
-
1XBY
2
ULAD_ECOLI
A:
[3-215]
--------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
8
PsiBlast_PDB
78.25
47%
-72
- C2 -
-
1Q6Q
2
ULAD_ECOLI
A:
[2-215]
-------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
-
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
5
PsiBlast_PDB
78.20
47%
-70
- C2 -
-
1KW1
2
ULAD_ECOLI
A:
[3-215]
--------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
16
PsiBlast_PDB
78.19
45%
-71
- C2 -
-
1XBX
2
ULAD_ECOLI
A:
[3-215]
--------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
V
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
11
PsiBlast_PDB
78.00
46%
-69
- C2 -
-
1SO5
2
ULAD_ECOLI
A:
[3-215]
--------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
Q
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
17
PsiBlast_PDB
76.72
45%
-80
- C2 -
-
1XBZ
2
ULAD_ECOLI
A:
[3-215]
--------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
----
A
K
----
E
F
---
N
-------
G
D
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
V
D
A
Q
---
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
92
HHSearch
74.19
44%
-76
- C2 -
-
3IEB
4
?
B:
[5-217]
-------------
T
K
P
M
I
Q
I
A
L
D
Q
T
N
L
T
D
A
V
A
V
A
S
N
V
A
S
Y
V
D
V
I
E
V
G
T
I
L
A
F
A
E
G
M
K
A
V
S
T
L
R
H
N
H
P
N
H
I
L
V
C
D
M
K
T
T
D
G
G
A
I
L
S
R
M
A
F
E
A
G
A
D
W
I
T
V
S
A
A
A
H
I
A
T
----
I
A
A
CKKV
A
D
----
E
L
---
N
-------
G
E
I
Q
I
E
I
Y
G
N
W
T
M
Q
D
A
K
A
W
V
D
L
G
I
T
Q
A
I
Y
H
R
S
R
D
A
E
L
A
G
I
G
W
T
T
D
D
L
D
K
M
R
Q
L
S
A
L
G
I
E
L
S
I
T
G
G
I
V
P
E
D
I
Y
L
F
E
G
I
K
T
K
T
--
F
I
A
G
R
A
L
A
G
A
E
-
G
Q
Q
T
A
A
A
L
R
E
Q
I
D
R
F
W
-