@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U1N6: (2017-12-21 )
MPFHSTPNKGGTFDMTVKVGINGFGRIGRLAFRRIKEVSDDIEVVAINDLTSPTMLAQLLQFDSTHGTYPGTVTATEDSIVVDGEATRVYAEPDASKIPWAKENGVDIVLECTGFYTSEEKAKAHLDAGVKRVVISAPAGAMKTIVYNVNDDTLDENDKIISAGSCTTNCLAPMAYFLNNEFGIEVGTMTTVHAYTSTQMLLDGPVKGGNLRAARSAADNTIPHSTGAAKAIGLVIPELQGKLQGHAQRVPVVDGSLTELVSVLKTKVTADQVNEAIKKHTVDNPSFGYDDRQIVSSDVIGTTQGSIFDPTQTEVTTAGDFQLVKTVAWYDNEYGFTCQMIRLLEKFANL
Atome Classification :
(30 SA)
.........10........20........30......---.-.---40.........-50.........60........70........80........90..-......100-.......110.......120.......130.......-140-..-......150....-..-.160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260...-..-...270.......280.-------.-...--..---------.290....-...300.......310-.......320.......330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPFHSTPNKGG
T
F
D
M
T
V
K
VGINGF
G
R
I
G
R
L
A
F
R
R
I
K
E
---V-S---D-D
I
E
V
V
A
IND-L-T
S
P
T
M
L
A
Q
L
L
Q
FDSTHGTYPG
T
V
T
ATE
D
S
I
V
VDGE
A
T
R
V
Y
AEP-DASKIPWAK-ENG
V
D
I
V
L
ECTGFYT
S
E
E
K
A
K
A
H
L
D
AG
V
K
R
V
V
I
SAPA-G-A-
M
K
-
T
I
V
Y
NVNDDTLDE-ND-
K
I
I
SAGSC
T
T
N
C
L
A
P
M
A
Y
F
LNNEF
G
I
E
VG
T
M
T
T
V
H
A
YT
S
T
Q
M
L
LDGPVKGGN
L
R
A
ARSAADNTIPHSTGA
A
K
A
I
G
L
V
I
P
E
L
Q
G
K
LQGHAQRVPVVDG
S
L
T
E
L
-
V
S
V
L
-
K
T-KV
T
A
D
Q
V
N
E
A
I
K
KHT-V-------D-NPS--FG---------YDD
R
Q
I
VS-SDVIGTTQGSIFDPTQ-
T
E
V
TTAGD
F
Q
L
V
K
T
V
A
W
YDNEYG
F
T
C
Q
M
I
R
L
L
E
K
F
ANL
2
PsiBlast_PDB
80.88
58%
-46
- C3 -
-
5VMT
2
?
A:
[9-339]
--------------
M
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
-
E
---
K
-
A
---
H
-
G
I
E
V
A
A
V
N
D
-
L
-
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
-
N
P
E
E
L
P
W
G
--
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
R
A
G
A
R
K
V
V
I
S
A
P
G
-
G
-
N
D
V
K
-
T
V
V
Y
G
V
N
Q
D
I
L
D
G
-
S
E
-
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
V
S
V
L
-
E
R
-
P
A
T
K
E
E
I
N
A
A
M
K
A
A
S
-
S
-------
E
---
S
--
Y
G
---------
Y
N
E
D
Q
I
V
S
-
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
--
24
PsiBlast_CBE
80.85
58%
-44
- C3 -
-
5VMT
2
?
D:
[9-339]
--------------
M
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
-
E
---
K
-
A
---
H
-
G
I
E
V
A
A
V
N
D
-
L
-
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
-
N
P
E
E
L
P
W
G
--
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
R
A
G
A
R
K
V
V
I
S
A
P
G
-
G
-
N
D
V
K
-
T
V
V
Y
G
V
N
Q
D
I
L
D
G
-
S
E
-
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
V
S
V
L
-
E
R
-
P
A
T
K
E
E
I
N
A
A
M
K
A
A
S
-
S
-------
E
---
S
--
Y
G
---------
Y
N
E
D
Q
I
V
S
-
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
--
40
PsiBlast_CBE
80.84
57%
-34
- C3 -
-
3VAZ
2
G3P1_STAAR
A:
[10-342]
---------------
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
21
PsiBlast_CBE
80.83
58%
-48
- C3 -
-
5VMT
2
?
H:
[10-339]
---------------
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
-
E
---
K
-
A
---
H
-
G
I
E
V
A
A
V
N
D
-
L
-
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
-
N
P
E
E
L
P
W
G
--
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
R
A
G
A
R
K
V
V
I
S
A
P
G
-
G
-
N
D
V
K
-
T
V
V
Y
G
V
N
Q
D
I
L
D
G
-
S
E
-
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
V
S
V
L
-
E
R
-
P
A
T
K
E
E
I
N
A
A
M
K
A
A
S
-
S
-------
E
---
S
--
Y
G
---------
Y
N
E
D
Q
I
V
S
-
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
--
47
PsiBlast_CBE
80.74
57%
-34
- C3 -
-
3LC1
3
G3P1_STAAR
O:
[2-334]
---------------
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
37
PsiBlast_CBE
80.67
57%
-32
- C3 -
-
3VAZ
2
G3P1_STAAR
Q:
[10-342]
---------------
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
22
PsiBlast_CBE
80.64
58%
-46
- C3 -
-
5VMT
2
?
G:
[11-339]
----------------
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
-
E
---
K
-
A
---
H
-
G
I
E
V
A
A
V
N
D
-
L
-
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
-
N
P
E
E
L
P
W
G
--
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
R
A
G
A
R
K
V
V
I
S
A
P
G
-
G
-
N
D
V
K
-
T
V
V
Y
G
V
N
Q
D
I
L
D
G
-
S
E
-
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
V
S
V
L
-
E
R
-
P
A
T
K
E
E
I
N
A
A
M
K
A
A
S
-
S
-------
E
---
S
--
Y
G
---------
Y
N
E
D
Q
I
V
S
-
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
--
36
PsiBlast_CBE
80.53
57%
-30
- C3 -
-
3VAZ
2
G3P1_STAAR
R:
[10-342]
---------------
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
69
PsiBlast_CBE
80.43
56%
-33
- C3 -
-
3KSZ
3
G3P1_STAAR
P:
[2-334]
---------------
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
4
PsiBlast_PDB
80.21
57%
-30
- C3 -
-
3L6O
-
G3P1_STAAR
Q:
[1-334]
--------------
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
42
PsiBlast_CBE
80.17
57%
-31
- C3 -
-
3LVF
2
G3P1_STAAR
Q:
[4-336]
---------------
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
17
PsiBlast_PDB
80.16
56%
-30
- C3 -
-
3KSD
2
G3P1_STAAR
Q:
[2-334]
---------------
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
9
PsiBlast_PDB
80.15
57%
-31
- C3 -
-
3LC1
3
G3P1_STAAR
P:
[1-334]
--------------
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
67
PsiBlast_CBE
80.08
56%
-30
- C3 -
-
3KSZ
3
G3P1_STAAR
R:
[2-334]
---------------
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
38
PsiBlast_CBE
80.01
57%
-35
- C3 -
-
3VAZ
3
G3P1_STAAR
O:
[10-342]
---------------
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
58
PsiBlast_CBE
79.92
57%
-31
- C3 -
-
3K9Q
3
G3P1_STAAR
P:
[1-334]
--------------
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
G
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
18
PsiBlast_PDB
79.90
56%
-29
- C3 -
-
3KSZ
3
G3P1_STAAR
O:
[2-334]
---------------
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
41
PsiBlast_CBE
79.88
57%
-34
- C3 -
-
3LVF
2
G3P1_STAAR
R:
[4-336]
---------------
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
49
PsiBlast_CBE
79.83
57%
-32
- C3 -
-
3KV3
3
G3P1_STAAR
Q:
[1-334]
--------------
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
---
V
-----
E
-
G
L
E
V
V
A
V
N
D
-
L
-
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
-
K
-
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
-
D
-
L
K
-
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
-
T
V
V
L
E
K
Q
-
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
--
F
G
---------
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
-
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
122
HHSearch
79.82
75%
4
- C3 -
-
5J9G
-
?
A:
[1-338]
--------------
M
T
V
K
I
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
M
D
---
L
-
G
E
K
S
K
-
D
I
E
V
V
A
I
N
D
-
L
-
T
T
P
A
L
L
A
H
L
L
K
Y
D
S
T
H
G
T
F
D
H
E
V
S
S
T
E
D
S
I
V
V
D
G
K
K
Y
R
V
Y
A
E
P
-
Q
A
Q
N
I
P
W
-
V
K
N
D
G
V
D
F
V
L
E
C
T
G
F
Y
T
S
K
A
K
S
Q
A
H
L
D
A
G
V
K
R
V
L
I
S
A
P
A
-
G
N
D
-
L
K
-
T
I
V
Y
S
V
N
Q
D
T
L
T
A
-
D
D
-
K
I
V
S
A
G
S
C
T
T
N
S
L
A
P
M
V
N
A
L
Q
K
E
F
G
I
E
V
G
T
M
T
T
I
H
A
Y
T
S
T
Q
M
I
L
D
G
P
V
R
G
G
N
L
R
A
A
R
A
A
A
I
N
I
I
P
H
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
N
G
H
A
Q
R
V
P
V
P
D
G
S
V
T
E
L
-
V
S
I
L
-
G
K
-
N
V
T
A
D
E
V
N
E
A
M
K
K
Y
E
-----------
S
P
S
--
F
E
---------
Y
E
P
N
N
V
V
S
-
S
D
I
L
G
R
T
A
G
S
I
F
D
P
T
Q
-
T
M
V
T
T
A
G
D
K
Q
L
V
K
T
V
A
W
Y
D
N
E
Y
S
F
T
C
Q
M
V
R
T
L
L
H
F
A
T
L
137
HHSearch
76.97
49%
-51
- C3 -
-
2EP7
1
G3P_AQUAE
B:
[2-340]
---------------
A
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
---
R
-----
E
-
E
I
E
I
V
A
I
N
D
-
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
E
A
K
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
-
D
P
S
Q
I
P
W
-
G
-
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
-
K
-
N
P
D
I
-
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
-
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
-
T
V
V
V
-
N
K
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGKV
Y
L
K
E
I
--
L
Q
---------
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
-
T
Q
V
I
----
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
86
PsiBlast_CBE
72.83
48%
-43
- C3 -
-
2EP7
1
G3P_AQUAE
A:
[3-334]
----------------
I
K
V
G
I
N
G
F
G
R
I
G
R
-
S
F
F
R
A
S
W
---
G
-
R
---
E
-
E
I
E
I
V
A
I
N
D
-
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
E
A
K
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
-
D
P
S
Q
I
P
W
G
--
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
-
K
-
N
-
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
-
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
K
--
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
-
K
A
-
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
-
Q
-------
K
-
Y
R
E
--
S
G
KVYLKEI
L
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
-
T
Q
V
I
D
----
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
------
85
PsiBlast_CBE
71.89
48%
-44
- C3 -
-
2EP7
1
G3P_AQUAE
B:
[2-334]
---------------
A
I
K
V
G
I
N
G
F
G
R
I
G
R
-
S
F
F
R
A
S
W
---
G
-
R
---
E
-
E
I
E
I
V
A
I
N
D
-
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
E
A
K
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
-
D
P
S
Q
I
P
W
G
--
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
-
K
-
N
-
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
-
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
K
--
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
-
K
A
-
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
-
Q
-------
K
-
Y
R
E
--
S
G
KVYLKEI
L
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
-
T
Q
V
I
D
----
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
------
126
HHSearch
71.74
44%
-9
- C3 -
-
3PYM
3
G3P3_YEAST
A:
[1-331]
---------------
M
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
I
A
L
S
---
R
-----
P
-
N
V
E
V
V
A
L
N
D
-
P
F
I
T
N
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
R
Y
A
G
E
V
S
H
D
D
K
H
I
I
V
D
G
K
K
I
A
T
Y
Q
E
R
-
D
P
A
N
L
P
W
-
G
-
S
S
N
V
D
I
A
I
D
S
T
G
V
F
K
E
L
D
T
A
Q
K
H
I
D
A
G
A
K
K
V
V
I
T
A
P
S
-
S
-
T
-
A
P
-
M
F
V
M
G
V
N
E
E
K
Y
T
S
-
D
L
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
P
S
H
-
K
D
W
R
G
G
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
-
T
V
K
L
-
N
K
-
E
T
T
Y
D
E
I
K
K
V
V
K
A
A
A
-
E
G
------
K
L
K
G
V
--
L
G
---------
Y
T
E
D
A
V
V
S
-
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
-
G
I
Q
L
S
---
P
K
F
V
K
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
-
125
HHSearch
69.50
44%
-8
- C3 -
-
3PYM
3
G3P3_YEAST
B:
[2-331]
----------------
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
I
A
L
S
---
R
-----
P
-
N
V
E
V
V
A
L
N
D
-
P
F
I
T
N
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
R
Y
A
G
E
V
S
H
D
D
K
H
I
I
V
D
G
K
K
I
A
T
Y
Q
E
R
-
D
P
A
N
L
P
W
-
G
-
S
S
N
V
D
I
A
I
D
S
T
G
V
F
K
E
L
D
T
A
Q
K
H
I
D
A
G
A
K
K
V
V
I
T
A
P
S
-
S
-
T
-
A
P
-
M
F
V
M
G
V
N
E
E
K
Y
T
S
-
D
L
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
P
S
H
-
K
D
W
R
G
G
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
-
T
V
K
L
-
N
K
-
E
T
T
Y
D
E
I
K
K
V
V
K
A
A
A
-
E
G
------
K
L
K
G
V
--
L
G
---------
Y
T
E
D
A
V
V
S
-
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
-
G
I
Q
L
S
---
P
K
F
V
K
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
-
107
Fugue
68.51
49%
12
- C3 -
-
1HDG
1
G3P_THEMA
O:
[1-332]
----------------
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
RKN
P
-
D
------
I
E
V
V
A
I
N
D
L--
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
-P
D
P
S
K
L
P
W
K
D
-
L
-
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
-
E
-
D
I
-
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
-H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
-
H
K
D
L
R
R
A
R
A
A
-
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
-
T
V
L
V
-
E
K
-
E
T
T
V
E
E
V
N
A
V
M
K
E
A
T
-
E
-------
G
-
R
L
K
GI
I
G
---------
Y
N
D
E
P
I
V
S
S-
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
----
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
84
PsiBlast_CBE
68.08
50%
12
- C3 -
-
1HDG
1
G3P_THEMA
O:
[2-332]
-----------------
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
---
R
-
K
---
N
P
D
I
E
V
V
A
I
N
D
-
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
-
D
P
S
K
L
P
W
-
K
-
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
-
E
-
D
I
-
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
--
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
-
T
V
L
V
-
E
K
-
E
T
T
V
E
E
V
N
A
V
M
K
E
A
T
-
E
-------
G
-
R
L
K
GI
I
G
---------
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
-
T
N
V
I
G
G
---
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
83
PsiBlast_CBE
67.43
50%
9
- C3 -
-
1HDG
1
G3P_THEMA
Q:
[2-332]
-----------------
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
---
R
-
K
---
N
P
D
I
E
V
V
A
I
N
D
-
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
-
D
P
S
K
L
P
W
-
K
-
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
-
E
-
D
I
-
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
--
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
-
T
V
L
V
-
E
K
-
E
T
T
V
E
E
V
N
A
V
M
K
E
A
T
-
E
-------
G
-
R
L
K
GI
I
G
---------
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
-
T
N
V
I
G
G
---
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
99
PsiBlast_CBE
66.19
46%
-4
- C3 -
-
3L0D
1
?
B:
[22-353]
--------------
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
---
S
G
R
---
Q
-
D
I
E
V
V
A
L
N
D
-
L
-
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
P
G
T
V
Q
V
V
G
D
A
I
D
I
---
L
I
K
V
F
A
E
R
-
D
P
A
Q
L
P
W
-
K
-
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
S
E
G
-
A
-
D
L
-
T
V
V
Y
G
V
N
H
Q
F
L
S
K
-
E
H
-
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
R
--
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
-
T
F
T
A
-
K
R
-
S
T
T
I
E
E
I
N
T
A
I
R
T
A
A
-
Q
-------
G
-
S
L
K
GI
L
D
---------
Y
T
D
E
K
L
V
S
-
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
-
T
K
V
I
---
D
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
--
100
PsiBlast_CBE
65.43
46%
-3
- C3 -
-
3L0D
1
?
A:
[22-353]
--------------
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
---
S
G
R
---
Q
-
D
I
E
V
V
A
L
N
D
-
L
-
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
P
G
T
V
Q
V
V
G
D
A
I
D
I
---
L
I
K
V
F
A
E
R
-
D
P
A
Q
L
P
W
-
K
-
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
S
E
G
-
A
-
D
L
-
T
V
V
Y
G
V
N
H
Q
F
L
S
K
-
E
H
-
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
R
--
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
-
T
F
T
A
-
K
R
-
S
T
T
I
E
E
I
N
T
A
I
R
T
A
A
-
Q
-------
G
-
S
L
K
GI
L
D
---------
Y
T
D
E
K
L
V
S
-
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
-
T
K
V
I
---
D
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
--