@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U1P9: (2017-12-21 )
MISKKSKDKEELKMTAIYNSVTELIGKTPIVKLNKIVPEDSADVFVKLEFFNPGGSVKDRIALSMIEKAEHDGLLKPGDTIIEPTSGNTGIGLSMVGVAKGYKVIIVMPETMSIERRLLMKGYGAELILTPGADGISGSIREAERLAKENGYFLPLQFENEANPLVHEKTTGPEIHQAFGVNGLDAFVAGIGTGGTITGAGRELKRVYPKSRINRGRTSRICYFRRERSGTSQNPRNRYRFCS
Atome Classification :
(66 SA)
.........10........20........30..---.....----.40-.--.--.......50........60........70.......--.80-.-.......90........100.......110.......120.......130--..---.....---.---140...-...-.--150......-...160.......170.......180.-......190.......200......-.210.......220......-----.------230.......240.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MISKKSK
D
K
E
E
L
K
M
T
A
I
Y
N
S
V
T
E
L
IGKTP
I
V
K
L
---
N
KIVP----ED--S--A--
D
V
F
V
K
L
E
F
FNPGGS
V
K
D
R
I
A
L
S
M
I
E
K
AEHDGLLKPG--D
T
I
-
I
-EPTSGNT
G
I
G
L
S
M
V
GVAKG
Y
K
V
I
I
V
MPET
M
S
I
E
R
R
L
L
M
KGYG
A
E
L
I
LTP---GA---DGIS
G
---
S
---
I
R
E
A
E
R
-
L
A
K-E--N--G
Y
F
L
P
L
-
Q
FENEANPLVHEKTTGP
E
I
H
Q
A
FGV
N
G
-
L
D
A
F
V
A
GIGTG
G
T
I
TGA
G
R
E
L
K
R
VY-
P
K
S
RINRGRTS
R
I
C
Y
F
R
RER-----S------GTSQNPRNRYRFCS
1
PsiBlast_PDB
87.48
67%
0
- C- -
-
2EGU
-
?
A:
[1-222]
-------------
M
A
R
T
V
N
S
I
T
E
L
I
G
D
T
P
A
V
K
L
---
N
R
I
V
D
----
E
D
--
S
--
A
--
D
V
Y
L
K
L
E
F
M
N
P
G
S
S
V
K
D
R
I
A
L
A
M
I
E
A
A
E
K
A
G
K
L
K
P
G
--
D
T
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
V
A
A
A
K
G
Y
K
A
V
L
V
M
P
D
T
M
S
L
E
R
R
N
L
L
R
A
Y
G
A
E
L
V
L
T
P
---
G
A
---
Q
G
M
R
G
---
A
---
I
A
K
A
E
E
-
L
V
R
-
E
--
H
--
G
Y
F
M
P
---------------
T
T
G
K
E
I
V
E
Q
M
G
-
D
Q
-
L
D
A
F
V
A
G
V
G
T
G
G
T
I
T
G
A
G
K
V
L
R
E
A
Y
-
P
N
I
K
I
-----------------------------------------
133
HHSearch
83.33
46%
-55
- C4 -
-
3X44
1
DCSD_STRLA
A:
[2-225]
---------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
---
Q
R
M
A
P
----
E
---
H
--
T
--
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
--
D
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
---
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
R
-
P
E
V
R
V
V
A
L
E
P
S
N
A
A
M
L
A
R
G
E
-----
W
------
S
P
H
Q
I
Q
G
L
A
P
N
---
127
HHSearch
79.08
43%
0
- C- -
-
4QL4
-
?
A:
[3-231]
----------------
V
Y
R
G
V
H
E
L
I
G
H
T
P
I
V
E
I
---
T
R
F
S
L
----
P
E
--
G
--
V
--
R
L
F
A
K
L
E
F
Y
N
P
G
G
S
V
K
D
R
L
G
R
E
L
I
E
D
A
L
E
K
G
L
V
T
E
G
--
G
T
I
-
I
-
E
P
T
A
G
N
T
G
I
G
L
A
L
A
A
L
Q
H
D
L
R
V
I
V
C
V
P
E
K
F
S
I
E
K
Q
E
L
M
K
A
L
G
A
T
V
V
H
T
P
---
T
E
---
Q
G
M
T
G
---
A
---
I
A
K
A
K
E
-
L
V
N
-
E
I
-
P
--
N
S
Y
S
P
S
-
Q
F
A
N
E
A
N
P
R
A
Y
F
K
T
L
G
P
E
L
W
S
A
L
N
G
-
E
-
I
N
I
F
V
A
G
A
G
T
G
G
T
F
M
G
T
A
S
Y
L
K
E
K
N
-
I
D
I
K
T
V
I
V
E
P
E
G
S
I
--------------------------------
106
PsiBlast_CBE
78.57
46%
0
- C- -
-
4AIR
4
?
A:
[32-255]
----------------
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
---
N
K
L
-
N
----
N
T
--
K
--
A
--
K
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
G
--
K
S
V
-
V
V
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
G
M
K
G
---
A
---
V
T
M
A
K
K
-
I
V
T
-
A
--
N
P
-
N
A
V
L
A
D
-
Q
F
A
T
K
Y
N
A
L
I
H
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
N
--
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
K
M
G
-
S
H
A
R
I
-----------------------------------------
105
PsiBlast_CBE
78.57
46%
0
- C- -
-
4AIR
3
?
B:
[32-254]
----------------
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
---
N
K
L
-
N
----
N
T
--
K
--
A
--
K
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
G
--
K
S
V
-
V
V
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
G
M
K
G
---
A
---
V
T
M
A
K
K
-
I
V
T
-
A
--
N
P-
N
A
V
L
A
D
-
Q
F
A
T
K
Y
N
A
L
I
H
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
N
--
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
K
M
G
-
S
H
A
R
I
-----------------------------------------
119
HHSearch
78.00
48%
-35
- C4 -
-
2Q3B
2
CYSK_MYCTU
A:
[4-229]
--------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
---
R
R
V
T
D
----
G
A
--
V
--
A
--
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
D
--
T
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
---
A
---
I
A
K
A
E
E
-
L
A
K
-
T
--
D
Q-
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
K
-
P
S
A
R
F
V
A
V
E
P
A
A
S
P
V
L
S
G
G
Q
-----
K
------
G
P
H
P
I
Q
G
I
G
A
G
---
55
PsiBlast_CBE
77.91
51%
-80
- C4 -
-
3X43
1
DCSD_STRLA
C:
[3-170]
----------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
---
Q
R
M
A
P
----
E
H
--
T
--
S
---
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
--
D
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
---
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
----------------------------------------------------------------------
117
HHSearch
76.96
46%
-39
- C4 -
-
5XA2
-
?
A:
[3-226]
----------------
I
F
K
D
N
S
E
S
I
G
R
T
P
L
V
Q
I
---
N
R
L
T
A
----
G
L
--
S
--
S
--
R
V
L
A
K
I
E
G
R
N
P
A
Y
S
V
K
C
R
I
G
A
A
M
I
W
D
A
E
Q
S
G
K
L
K
P
G
--
M
H
V
-
V
-
E
P
T
S
G
N
T
G
I
A
L
A
F
V
C
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
M
M
L
K
S
F
G
A
D
L
V
L
T
P
---
G
A
---
D
G
M
K
G
---
A
---
I
S
K
A
E
E
-
L
A
A
-
Q
--
P
--
G
W
F
I
P
Q
-
Q
F
K
N
P
A
N
P
A
I
H
V
K
T
T
G
P
E
I
W
N
D
T
E
G
-
Q
-
V
D
V
F
V
A
G
V
G
T
G
G
T
I
T
G
V
A
R
F
L
K
H
E
K
K
H
P
V
H
V
V
A
V
E
P
A
A
S
P
V
L
A
G
G
P
-----
A
------
G
R
H
K
I
Q
G
I
G
A
G
---
18
PsiBlast_PDB
76.81
51%
-85
- C4 -
-
3X43
1
DCSD_STRLA
A:
[3-170]
----------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
---
Q
R
M
A
P
----
E
H
--
T
--
S
---
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
--
D
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
---
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
----------------------------------------------------------------------
51
PsiBlast_CBE
76.72
51%
-79
- C4 -
-
3X43
1
DCSD_STRLA
G:
[3-170]
----------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
---
Q
R
M
A
P
----
E
H
--
T
--
S
---
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
--
D
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
---
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
----------------------------------------------------------------------
123
HHSearch
76.25
48%
-29
- C4 -
-
2Q3D
-
CYSK_MYCTU
A:
[4-229]
--------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
---
R
R
V
T
D
----
G
A
--
V
--
A
--
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
D
--
T
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
---
A
---
I
A
K
A
E
E
-
L
A
K
-
T
--
D
Q-
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
K
-
P
S
A
R
F
V
A
V
E
P
A
A
S
P
V
L
S
G
G
Q
-----
K
------
G
P
H
P
I
Q
G
I
G
A
G
---
20
PsiBlast_PDB
76.20
50%
-78
- C4 -
-
3X44
1
DCSD_STRLA
A:
[3-170]
----------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
---
Q
R
M
A
P
----
E
H
--
T
--
S
---
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
--
D
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
---
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
----------------------------------------------------------------------
56
PsiBlast_CBE
76.13
51%
-79
- C4 -
-
3X43
1
DCSD_STRLA
B:
[3-170]
----------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
---
Q
R
M
A
P
----
E
H
--
T
--
S
---
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
--
D
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
---
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
----------------------------------------------------------------------
53
PsiBlast_CBE
75.97
51%
-81
- C4 -
-
3X43
1
DCSD_STRLA
E:
[3-170]
----------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
---
Q
R
M
A
P
----
E
H
--
T
--
S
---
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
--
D
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
---
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
----------------------------------------------------------------------
52
PsiBlast_CBE
75.76
51%
-79
- C4 -
-
3X43
1
DCSD_STRLA
F:
[3-170]
----------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
---
Q
R
M
A
P
----
E
H
--
T
--
S
---
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
--
D
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
---
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
----------------------------------------------------------------------
58
PsiBlast_CBE
75.65
50%
-78
- C4 -
-
3X44
1
DCSD_STRLA
B:
[3-170]
----------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
---
Q
R
M
A
P
----
E
H
--
T
--
S
---
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
--
D
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
---
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
----------------------------------------------------------------------
50
PsiBlast_CBE
74.32
51%
-77
- C4 -
-
3X43
1
DCSD_STRLA
H:
[3-170]
----------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
---
Q
R
M
A
P
----
E
H
--
T
--
S
---
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
--
D
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
---
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
----------------------------------------------------------------------
54
PsiBlast_CBE
74.13
51%
-77
- C4 -
-
3X43
1
DCSD_STRLA
D:
[3-170]
----------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
---
Q
R
M
A
P
----
E
H
--
T
--
S
---
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
--
D
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
---
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
----------------------------------------------------------------------
7
PsiBlast_PDB
73.02
56%
-88
- C4 -
-
4I1Y
-
?
A:
[7-196]
----------------
I
A
E
N
I
A
Q
L
I
G
G
T
P
L
V
R
L
---
R
R
V
T
D
----
G
A
--
A
--
A
--
D
V
V
A
K
L
E
S
F
N
P
A
G
S
I
K
D
R
I
G
V
A
M
I
D
A
A
E
K
A
G
L
I
K
P
D
--
T
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
S
A
A
R
G
Y
K
C
V
L
T
M
P
D
T
M
S
I
E
R
R
M
L
L
R
A
Y
G
A
E
L
V
L
T
P
---
G
A
---
E
G
M
A
G
---
A
---
I
A
K
A
E
E
-
L
A
K
T
D
--
D
--
R
Y
F
I
P
Q
-------
N
P
A
V
H
A
V
T
T
A
E
E
V
W
R
-------------------------------------------------------------------------------
8
PsiBlast_PDB
72.77
52%
-56
- C4 -
-
5XA2
-
?
A:
[3-174]
----------------
I
F
K
D
N
S
E
S
I
G
R
T
P
L
V
Q
I
---
N
R
L
T
A
----
G
L
--
S
--
S
--
R
V
L
A
K
I
E
G
R
N
P
A
Y
S
V
K
C
R
I
G
A
A
M
I
W
D
A
E
Q
S
G
K
L
K
P
G
--
M
H
V
-
V
-
E
P
T
S
G
N
T
G
I
A
L
A
F
V
C
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
M
M
L
K
S
F
G
A
D
L
V
L
T
P
---
G
A
---
D
G
M
K
G
---
A
---
I
S
K
A
E
E
-
L
A
A
-
Q
--
P
--
G
W
F
I
P
Q
-
Q
F
K
N
P
A
N
P
A
I
H
V
K
T
T
G
P
E
I
W
N
--
D
T
E
G
Q
V
D
V
F
V
A
------------------------------------------------------------------
2
PsiBlast_PDB
72.33
56%
-73
- C4 -
-
3ZEI
2
CYSK_MYCTU
A:
[2-164]
---------------
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
---
R
R
V
T
D
----
G
A
--
V
--
A
--
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
D
--
T
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
---
A
---
I
A
K
A
E
E
-
L
A
K
T
D
--
Q
--
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
-------------------------------------------------------------------------------
4
PsiBlast_PDB
72.23
55%
-77
- C4 -
-
2Q3B
2
CYSK_MYCTU
A:
[5-167]
---------------
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
---
R
R
V
T
D
----
G
A
--
V
--
A
--
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
D
--
T
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
---
A
---
I
A
K
A
E
E
-
L
A
K
T
D
--
Q
--
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
-------------------------------------------------------------------------------
135
HHSearch
72.14
43%
27
- C4 -
-
3PC3
2
?
A:
[51-284]
-----------------
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
---
N
N
I
P
A
----
S
D
--
G
IE
C
--
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
G
--
Y
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
---
T
E
---
A
A
Y
D
S
PEG
L
---
I
Y
V
A
Q
Q
-
L
Q
R
-
E
T
-
P
--
N
S
I
V
L
D
-
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
-
K
-
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
V
-
P
S
C
Q
I
V
G
V
D
P
Y
G
S
I
L
A
-
R
P
A
-----
E
LNKTDV
Q
F
Y
E
V
E
G
I
G
Y
D
F
--
85
PsiBlast_CBE
72.09
47%
-53
- C4 -
-
2V03
3
CYSM_ECOLI
A:
[2-187]
------------------
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
---
Q
R
M
G
P
----
D
N
--
G
--
S
--
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
--
D
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
---
A
---
R
D
L
A
L
E
-
M
A
N
-
R
--
G
--
E
G
K
L
L
D
-
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
-
G
R
-
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--------------------------------------------------
63
PsiBlast_CBE
71.91
48%
-55
- C4 -
-
2BHS
1
CYSM_ECOLI
C:
[2-187]
------------------
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
---
Q
R
M
G
P
----
D
N
--
G
--
S
--
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
--
D
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
---
A
---
R
D
L
A
L
E
-
M
A
N
-
R
--
G
--
E
G
K
L
L
D
-
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
-
G
R
-
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--------------------------------------------------
65
PsiBlast_CBE
71.23
48%
-56
- C4 -
-
2BHS
1
CYSM_ECOLI
A:
[2-187]
------------------
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
---
Q
R
M
G
P
----
D
N
--
G
--
S
--
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
--
D
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
---
A
---
R
D
L
A
L
E
-
M
A
N
-
R
--
G
--
E
G
K
L
L
D
-
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
-
G
R
-
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--------------------------------------------------
61
PsiBlast_CBE
71.10
47%
28
- C4 -
-
3PC2
2
?
A:
[50-251]
----------------
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
---
N
N
I
P
A
----
S
D
GI
E
--
C
--
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
G
--
Y
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
TEA
A
Y
---
D
S
P
E
G
---
L
---
I
Y
V
A
Q
Q
-
L
Q
R
-
E
--
T
--
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
-
N
K
-
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
V
-
P
S
C
Q
I
-----------------------------------------
59
PsiBlast_CBE
70.44
47%
33
- C4 -
-
3PC4
2
?
A:
[50-251]
----------------
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
---
N
N
I
P
A
----
S
D
GI
E
--
C
--
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
G
--
Y
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
TEA
A
Y
---
D
S
P
E
G
---
L
---
I
Y
V
A
Q
Q
-
L
Q
R
-
E
--
T
--
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
-
N
K
-
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
V
-
P
S
C
Q
I
-----------------------------------------
60
PsiBlast_CBE
70.36
47%
32
- C4 -
-
3PC3
2
?
A:
[50-251]
----------------
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
---
N
N
I
P
A
----
S
D
GI
E
--
C
--
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
G
--
Y
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
TEA
A
Y
---
D
S
P
E
G
---
L
---
I
Y
V
A
Q
Q
-
L
Q
R
-
E
--
T
--
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
-
N
K
-
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
V
-
P
S
C
Q
I
-----------------------------------------
64
PsiBlast_CBE
70.17
48%
-58
- C4 -
-
2BHS
1
CYSM_ECOLI
B:
[2-187]
------------------
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
---
Q
R
M
G
P
----
D
N
--
G
--
S
--
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
--
D
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
---
A
---
R
D
L
A
L
E
-
M
A
N
-
R
--
G
--
E
G
K
L
L
D
-
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
-
G
R
-
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--------------------------------------------------
62
PsiBlast_CBE
69.29
48%
-55
- C4 -
-
2BHS
1
CYSM_ECOLI
D:
[2-187]
------------------
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
---
Q
R
M
G
P
----
D
N
--
G
--
S
--
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
--
D
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
---
A
---
R
D
L
A
L
E
-
M
A
N
-
R
--
G
--
E
G
K
L
L
D
-
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
-
G
R
-
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--------------------------------------------------
137
HHSearch
69.01
44%
7
- C4 -
-
4AEC
2
CYSKM_ARATH
A:
[113-337]
----------------
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
---
N
S
I
A
K
----
G
C
--
V
--
A
--
N
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
G
K-
S
V
L
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
---
P
A
---
K
G
M
T
G
---
A
---
V
Q
K
A
E
E
-
I
L
K
-
N
T-
P
--
D
A
Y
M
L
Q
-
Q
F
D
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
-
K
-
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
K
N
-
P
K
T
Q
V
I
G
V
E
P
T
E
S
D
I
L
S
G
G
K
-----
P
------
G
P
H
K
I
Q
G
I
G
A
G
---
19
PsiBlast_PDB
68.44
49%
38
- C4 -
-
4COO
5
CBS_HUMAN
A:
[94-302]
------------
K
S
P
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
---
N
K
I
G
K
----
K
F
GL
K
--
C
--
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
--
D
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
S
P
E
S
---
H
---
V
G
V
A
W
R
-
L
K
N
-
E
I
P
N
--
S
H
I
L
D
--
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
-
G
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
-
P
G
C
R
I
-----------------------------------------
115
PsiBlast_CBE
68.43
43%
8
- C4 -
-
5HBG
1
CYSM_HELPY
B:
[3-201]
----------------
I
I
T
T
M
Q
D
A
I
G
R
T
P
V
F
K
F
TNK
D
Y
P
I
P
----
L
N
--
S
--
A
---
I
Y
A
K
L
E
H
L
N
P
G
G
S
V
K
D
R
L
G
Q
Y
L
I
G
E
G
F
K
T
G
K
I
T
S
K
--
T
T
I
-
I
-
E
P
T
A
G
N
T
G
I
A
L
A
L
V
A
I
K
H
H
L
K
T
I
F
V
V
P
E
K
F
S
T
E
K
Q
Q
I
M
R
A
L
G
A
L
V
I
N
T
P
---
T
S
---
E
G
I
S
G
---
A
---
I
K
K
S
K
E
-
L
A
E
-
S
I-
P
--
D
S
Y
L
P
L
-
Q
F
E
N
P
D
N
P
A
A
Y
Y
H
T
L
A
P
E
I
V
Q
E
L
G
T
N
--
L
T
S
F
V
A
G
I
G
S
G
G
T
F
A
G
T
A
R
Y
L
K
E
R
I
-
P
A
I
R
L
-----------------------------------------
44
PsiBlast_CBE
68.33
49%
33
- C4 -
-
4L0D
2
CBS_HUMAN
B:
[72-280]
------------
K
S
P
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
---
N
K
I
G
K
----
K
F
GL
K
--
C
--
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
--
D
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
S
P
E
S
---
H
---
V
G
V
A
W
R
-
L
K
N
-
E
I
P
N
--
S
H
I
L
D
--
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
-
G
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
-
P
G
C
R
I
-----------------------------------------
57
PsiBlast_CBE
68.27
49%
38
- C4 -
-
4COO
3
CBS_HUMAN
B:
[94-308]
------------
K
S
P
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
---
N
K
I
G
K
----
K
F
GL
K
--
C
--
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
--
D
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
S
P
E
S
---
H
---
V
G
V
A
W
R
-
L
K
N
-
E
I
P
N
--
S
H
I
L
D
--
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
-
G
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
-
P
G
C
R
I
-----------------------------------------
67
PsiBlast_CBE
68.17
52%
10
- C4 -
-
2EFY
2
?
A:
[7-196]
------------------------
I
G
K
T
P
V
V
R
L
---
A
K
V
V
E
----
P
D
--
M
--
A
--
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
SG
Q
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
---
A
---
R
E
E
A
L
R
-
L
K
E
-
E
--
L
--
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
-
E
G
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
I
-
P
H
V
K
V
-----------------------------------------
118
HHSearch
68.10
45%
47
- C4 -
-
4COO
3
CBS_HUMAN
B:
[95-342]
-------------
S
P
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
---
N
K
I
G
K
----
K
F
--
G
LK
C
--
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
--
D
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
---
A
R
F
D
S
---
P
ES
H
V
G
V
A
W
R
-
L
K
N
-
E
I
-
P
--
N
S
H
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
-
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
-
P
G
C
R
I
I
G
V
D
P
E
G
S
I
L
A
E
P
E
E
LNQTE
Q
------
T
T
Y
E
V
E
G
I
G
Y
D
F
I
-
16
PsiBlast_PDB
68.10
49%
35
- C4 -
-
4L0D
2
CBS_HUMAN
A:
[72-282]
------------
K
S
P
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
---
N
K
I
G
K
----
K
F
GL
K
--
C
--
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
--
D
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
S
P
E
S
---
H
---
V
G
V
A
W
R
-
L
K
N
-
E
I
P
N
--
S
H
I
L
D
--
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
-
G
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
-
P
G
C
R
I
-----------------------------------------
10
PsiBlast_PDB
68.07
49%
39
- C4 -
-
4PCU
2
CBS_HUMAN
A:
[72-282]
------------
K
S
P
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
---
N
K
I
G
K
----
K
F
GL
K
--
C
--
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
--
D
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
-----ARF
D
S
P
S
S
---
H
---
V
G
V
A
W
R
-
L
K
N
-
E
I
P
N
--
S
H
I
L
D
--
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
-
G
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
-
P
G
C
R
I
-----------------------------------------
25
PsiBlast_CBE
68.00
49%
37
- C4 -
-
4PCU
2
CBS_HUMAN
B:
[72-283]
------------
K
S
P
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
---
N
K
I
G
K
----
K
F
GL
K
--
C
--
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
--
D
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
S
P
S
S
---
H
---
V
G
V
A
W
R
-
L
K
N
-
E
I
P
N
--
S
H
I
L
D
--
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
-
G
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
-
P
G
C
R
I
-----------------------------------------
124
HHSearch
67.93
46%
14
- C4 -
-
2ISQ
1
CYSK1_ARATH
A:
[3-227]
----------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
---
N
N
V
A
E
----
G
C
--
V
--
G
--
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
G
E-
S
V
L
-
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
G
M
K
G
---
A
---
I
A
K
A
E
E
-
I
L
A
-
K
T-
P
--
N
G
Y
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
-
K
-
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
N
-
A
N
V
K
L
Y
G
V
E
P
V
E
S
A
I
L
S
G
G
K
-----
P
------
G
P
H
K
I
Q
G
I
G
A
G
---
66
PsiBlast_CBE
67.72
52%
11
- C4 -
-
2EFY
2
?
B:
[7-196]
------------------------
I
G
K
T
P
V
V
R
L
---
A
K
V
V
E
----
P
D
--
M
--
A
--
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
SG
Q
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
---
A
---
R
E
E
A
L
R
-
L
K
E
-
E
--
L
--
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
-
E
G
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
I
-
P
H
V
K
V
-----------------------------------------
128
HHSearch
67.64
46%
11
- C4 -
-
1Z7W
1
CYSK1_ARATH
A:
[4-229]
---------------
R
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
---
N
N
V
A
E
----
G
C
--
V
--
G
--
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
G
E-
S
V
L
-
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
G
M
K
G
---
A
---
I
A
K
A
E
E
-
I
L
A
-
K
T-
P
--
N
G
Y
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
-
K
-
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
N
-
A
N
V
K
L
Y
G
V
E
P
V
E
S
A
I
L
S
G
G
K
-----
P
------
G
P
H
K
I
Q
G
I
G
A
G
---
81
PsiBlast_CBE
67.13
49%
10
- C4 -
-
4AEC
2
CYSKM_ARATH
B:
[113-310]
----------------
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
---
N
S
I
A
K
----
G
C
--
V
--
A
--
N
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
G
--
K
S
V
L
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
---
P
A
---
K
G
M
T
G
---
A
---
V
Q
K
A
E
E
-
I
L
K
-
N
TP
D
--
A
Y
M
L
Q
--
Q
F
D
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
D
D
T
K
-
G
K
-
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
K
N
-
P
K
T
Q
V
-----------------------------------------
68
PsiBlast_CBE
66.40
52%
14
- C4 -
-
2ECQ
2
?
A:
[7-196]
------------------------
I
G
K
T
P
V
V
R
L
---
A
K
V
V
E
----
P
D
--
M
--
A
--
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
SG
Q
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
---
A
---
R
E
E
A
L
R
-
L
K
E
-
E
--
L
--
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
-
E
G
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
I
-
P
H
V
K
V
-----------------------------------------
82
PsiBlast_CBE
66.25
49%
12
* C4 *
-
4AEC
2
CYSKM_ARATH
A:
[113-310]
----------------
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
---
N
S
I
A
K
----
G
C
--
V
--
A
--
N
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
G
--
K
S
V
L
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
---
P
A
---
K
G
M
T
G
---
A
---
V
Q
K
A
E
E
-
I
L
K
-
N
TP
D
--
A
Y
M
L
Q
--
Q
F
D
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
D
D
T
K
-
G
K
-
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
K
N
-
P
K
T
Q
V
-----------------------------------------
69
PsiBlast_CBE
66.10
52%
12
- C4 -
-
2ECO
2
?
A:
[7-196]
------------------------
I
G
K
T
P
V
V
R
L
---
A
K
V
V
E
----
P
D
--
M
--
A
--
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
SG
Q
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
---
A
---
R
E
E
A
L
R
-
L
K
E
-
E
--
L
--
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
-
E
G
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
I
-
P
H
V
K
V
-----------------------------------------
70
PsiBlast_CBE
65.97
52%
14
- C4 -
-
1VE1
1
?
A:
[7-196]
------------------------
I
G
K
T
P
V
V
R
L
---
A
K
V
V
E
----
P
D
--
M
--
A
--
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
SG
Q
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
---
A
---
R
E
E
A
L
R
-
L
K
E
-
E
--
L
--
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
-
E
G
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
I
-
P
H
V
K
V
-----------------------------------------
89
PsiBlast_CBE
65.23
50%
-35
- C4 -
-
1FCJ
1
CYSK_SALTY
C:
[3-162]
----------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
---
N
R
I
-------
G
--
N
--
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
--
V
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
---
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
Y
L
L
L
Q
-
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
-------------------------------------------------------------------------------
95
PsiBlast_CBE
64.76
50%
-36
- C4 -
-
1D6S
1
CYSK_SALTY
B:
[3-162]
----------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
---
N
R
I
-------
G
--
N
--
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
--
V
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
---
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
Y
L
L
L
Q
-
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
-------------------------------------------------------------------------------
91
PsiBlast_CBE
64.69
50%
-41
- C4 -
-
1FCJ
1
CYSK_SALTY
A:
[3-162]
----------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
---
N
R
I
-------
G
--
N
--
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
--
V
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
---
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
Y
L
L
L
Q
-
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
-------------------------------------------------------------------------------
96
PsiBlast_CBE
64.63
50%
-35
- C4 -
-
1D6S
1
CYSK_SALTY
A:
[3-162]
----------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
---
N
R
I
-------
G
--
N
--
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
--
V
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
---
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
Y
L
L
L
Q
-
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
-------------------------------------------------------------------------------
88
PsiBlast_CBE
64.27
50%
-35
- C4 -
-
1FCJ
1
CYSK_SALTY
D:
[3-162]
----------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
---
N
R
I
-------
G
--
N
--
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
--
V
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
---
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
Y
L
L
L
Q
-
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
-------------------------------------------------------------------------------
87
PsiBlast_CBE
64.23
50%
-42
- C4 -
-
1OAS
1
CYSK_SALTY
A:
[3-162]
----------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
---
N
R
I
-------
G
--
N
--
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
--
V
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
---
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
Y
L
L
L
Q
-
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
-------------------------------------------------------------------------------
86
PsiBlast_CBE
64.18
50%
-43
- C4 -
-
1OAS
1
CYSK_SALTY
B:
[3-162]
----------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
---
N
R
I
-------
G
--
N
--
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
--
V
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
---
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
Y
L
L
L
Q
-
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
-------------------------------------------------------------------------------
90
PsiBlast_CBE
64.08
50%
-37
- C4 -
-
1FCJ
1
CYSK_SALTY
B:
[3-162]
----------------
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
---
N
R
I
-------
G
--
N
--
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
--
V
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
---
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
Y
L
L
L
Q
-
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
-------------------------------------------------------------------------------
71
PsiBlast_CBE
62.00
53%
-4
- C4 -
-
1Z7W
1
CYSK1_ARATH
A:
[5-178]
----------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
---
N
N
V
A
E
----
G
C
--
V
--
G
--
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
G
--
E
S
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
G
M
K
G
---
A
---
I
A
K
A
E
E
I
L
A
K
-
T
P-
N
--
G
Y
M
L
Q
--
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
-
G
K
-
I
D
G
F
V
S
------------------------------------------------------------------
83
PsiBlast_CBE
61.95
53%
-1
- C4 -
-
2ISQ
1
CYSK1_ARATH
A:
[3-176]
----------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
---
N
N
V
A
E
----
G
C
--
V
--
G
--
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
G
--
E
S
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
G
M
K
G
---
A
---
I
A
K
A
E
E
I
L
A
K
-
T
P-
N
--
G
Y
M
L
Q
--
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
-
G
K
-
I
D
G
F
V
S
------------------------------------------------------------------
109
PsiBlast_CBE
60.38
44%
18
- C4 -
-
2PQM
1
?
B:
[13-199]
----------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
---
H
G
V
T
E
HPRI
K
K
--
G
--
T
--
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
G
--
M
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
---
A
---
I
E
E
V
N
K
-
M
I
K
-
E
--
N
PG
K
Y
F
V
A
N
-
Q
F
G
N
P
D
N
T
A
A
H
H
Y
T
A
N
E
I
W
E
D
T
D
G
--
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
--------------------------------------------------------
110
PsiBlast_CBE
60.24
44%
12
- C4 -
-
2PQM
1
?
A:
[13-199]
----------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
---
H
G
V
T
E
HPRI
K
K
--
G
--
T
--
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
G
--
M
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
---
A
---
I
E
E
V
N
K
-
M
I
K
-
E
--
N
PG
K
Y
F
V
A
N
-
Q
F
G
N
P
D
N
T
A
A
H
H
Y
T
A
N
E
I
W
E
D
T
D
G
--
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
--------------------------------------------------------
108
PsiBlast_CBE
58.97
44%
10
- C4 -
-
3BM5
1
?
A:
[12-198]
----------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
---
H
G
V
T
E
HPRI
K
K
--
G
--
T
--
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
G
--
M
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
---
A
---
I
E
E
V
N
K
-
M
I
K
-
E
--
N
PG
K
Y
F
V
A
N
-
Q
F
G
N
P
D
N
T
A
A
H
H
Y
T
A
N
E
I
W
E
D
T
D
G
--
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
--------------------------------------------------------
107
PsiBlast_CBE
58.25
44%
20
- C4 -
-
3BM5
2
?
B:
[12-198]
----------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
---
H
G
V
T
E
HPRI
K
K
--
G
--
T
--
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
G
--
M
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
---
A
---
I
E
E
V
N
K
-
M
I
K
-
E
--
N
PG
K
Y
F
V
A
N
-
Q
F
G
N
P
D
N
T
A
A
H
H
Y
T
A
N
E
I
W
E
D
T
D
G
--
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
--------------------------------------------------------
92
PsiBlast_CBE
57.03
49%
25
- C4 -
-
4LMA
1
?
B:
[10-174]
----------------
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
---
N
R
I
P
Q
----
A
E
--
G
--
C
LG
R
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
P
E
--
T
T
V
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
---
G
S
---
Q
G
M
K
G
---
A
---
I
L
R
A
Q
Q
-
I
V
D
-
S
I-
P
--
G
A
Y
M
L
Q
-
Q
F
R
N
P
S
N
P
E
I
H
R
L
T
T
A
E
E
I
W
Q
-------------------------------------------------------------------------------
80
PsiBlast_CBE
55.76
52%
29
- C4 -
-
4LMB
3
?
A:
[10-172]
----------------
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
---
N
R
I
P
V
----
A
E
GV
K
--
A
--
R
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
D
--
K
T
I
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
---
G
S
---
Q
G
M
E
G
---
A
---
I
T
R
A
E
E
-
I
V
E
-
N
TP
N
--
A
Y
S
L
-
Q
-
Q
F
R
N
P
A
N
P
K
I
H
R
E
T
T
A
E
E
I
---------------------------------------------------------------------------------
93
PsiBlast_CBE
55.59
49%
31
- C4 -
-
4LMA
1
?
A:
[10-174]
----------------
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
---
N
R
I
P
Q
----
A
E
--
G
--
C
L
G
R
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
P
E
--
T
T
V
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
---
G
S
---
Q
G
M
K
G
---
A
---
I
L
R
A
Q
Q
-
I
V
D
-
S
I
-
P
--
G
A
Y
M
L
Q
-
Q
F
R
N
P
S
N
P
E
I
H
R
L
T
T
A
E
E
I
W
Q
-------------------------------------------------------------------------------