@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U1S3: (2017-12-21 )
MKQLSSAQVRQMFLDFFQSKGHTIEPSASLIPVNDPTLLWINSGVATLKKYFDGSVVPENPRITNAQKSIRTNDIENVGKTARHHTMFEMLGNFSIGDYFKNEAIHWAWEFLTDPKWMAFDPEKLYVTVYPKDTEAKRIWHEEVGLPLDHIIDVEDNFWDIGAGPCGPDTEIFYDRGEAYNDLAEDDPENYPGGENERYLEIWNLVFSEFNHKPDNTFEPLPHKNIDTGMGLERMVSIVQDASTNFETDLFMPIIHAVEKLSKQVKYGENPVTDISYKVIADHIRALSFAIGDGALPSNEGRGYVLRRLLRRAVMHGKKLGIEQAFLYRLVPVVGEIMVSYYPEVLQQKEFIEKVIRTEEERFNETINEGLEILNQVIQEVKNENGTTLAGKDIFKLYDTYGFPVELTEEVAEDEGLKVDHAGFEKEMDAQRERARSARSTEKSMGVQSALLTDIKVESKFIGYTEQESDSQLLVIVKGESLLNEVAEGEAQMIFDQTPFYAEMGGQVADQGWIMNEVGEIVAVVTDVQKAPNGQFMHTVEVKAPMSEGQTYHLLIDQSMRNRIIKNHTATHLLHKALKEVLGEHANQAGSLVAPGHLRFDFTHFGQITSDELAEMERIVNEKIWEAIPVETIETDIDTAKNMGAMALFGEKYGHDVRVVNIGGWSIELCGGTHVANTENIGIFKIVSESGIGAGVRRIEAVTSKEAYELLEEEEKQLKQVATIVKSPQLKEVVSKAEQLQQQVRELQKENEQLASKLANQQAGDVFKDPETINGKTIIAAQVKVKDMNQLRQLADQWKQKNISDILVLANEQEGKVSLLAAMTKESNEAGLKAGDLIKAIAPKVGGGGGGRPDMAQAGGKNPAGIPDALKAAKEWVAQQ
Atome Classification :
(27 SA)
.........10........20.-.......30........40........50....-...--.-----60-----........70.----.......80........90.......-----.100.......110.......120.......130------...--------......140.......150-.--..---------.....160-.......170....---...180.......190.......200.......210....-------...-------220.......230....-------------------...240....--...250.......260-----------.......------270---------------------------------------------...-----------.....-------------.280.......290.......300.......310.....-.-.320.........330.......340.......350.......360.......370.......380.......390.......400.......410.......420.-......430.......440.......450....-...460.....---..470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.-......--650..-.....660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKQ
L
S
S
A
Q
V
R
Q
M
F
L
D
F
F
Q
SKG
H
-
T
IEPSA
S
L
I
PVND
P
T
L
L
W
INS
G
V
A
T
L
K
K
YFDGS-VVP--E-----NP-----RIT
N
A
Q
KSIRT----N
D
I
E
N
V
G
K
T
A
R
H
H
T
M
F
E
M
L
GNFSI
G
D
-----
Y
F
KNE
A
I
H
W
A
W
E
FLTDPKWMAFDP
E
K
L
Y
V
T
V
Y--------PKD--------T
E
A
K
R
I
W
H
E
EVGLPL
D
H
I
--I--DV---------ED
N
F
W
DIG-AGPCGPDT
E
I
F
YDR---GEAYNDLAEDDPENYPGGE
N
E
R
Y
L
E
I
W
N
L
V
F
S
EFNHKPDN-------TFE-------PLPHKNIDTGM
G
L
E
R
M
V
-------------------
S
I
V
Q
DASTNF--E
T
D
L
F
M
P
I
I
H
A
V
E
K
L
S
-----------
K
Q
VKYGE------N-----------------------------------------------PVT-----------
D
I
S
Y
K
-------------
V
I
A
D
H
I
R
A
L
S
F
AIGDGALPSNEG
R
G
Y
V
L
R
R
L
L
R
R
A
V
MHG-K-KL--
G
I
E
Q
A
F
L
Y
R
L
V
P
V
V
G
E
I
M
V
S
Y
Y
P
E
V
L
Q
Q
K
E
F
I
E
K
V
I
R
T
E
E
E
R
F
N
E
T
I
N
E
G
L
E
I
L
N
Q
V
I
Q
E
V
KNENG
T
T
LA
G
K
D
I
F
K
L
Y
D
TYGF
P
V
E
L
T
E
E
VAEDEGLKVDHAG-
F
E
K
E
M
D
A
Q
R
E
R
A
R
SARS
T
E
K
SMG
V
Q
S
A
L
L
T
D
I
K
-
V
ES
K
F
IGYTEQ---ESD
S
Q
L
L
V
I
VK
G
E
S
L
L
N
E
V
AEGE
A
Q
M
I
FDQTP
F
Y
A
E
MGGQVADQG
W
I
M
N
E
V
G
E
I
V
A
V
V
T
D
V
Q
KAPNG
Q
F
M
H
T
V
E
V
KAPMSEG
Q
T
Y
H
L
L
I
D
Q
S
M
R
N
R
I
I
KN
H
T
A
T
H
L
L
H
K
A
L
K
E
V
L
G
E
H
ANQAGSLVAP
G
H
L
R
F
D
F
T
HFGQI
T
S
D
E
L
A
E
M
E
R
I
V
N
E
K
I
W
E
AIP
V
E
T
IE
T
D
I
D
T
A
KNM-
G
A
M
A
L
F
--
G
E
KYG-H
D
V
R
V
V
N
IG
G
W
S
I
E
LCGGTHVANTEN
I
G
I
F
K
I
VSESGI
G
A
G
V
R
R
I
E
A
V
T
S
K
E
A
Y
E
L
L
E
E
E
E
K
Q
L
K
Q
V
A
T
I
VKSP
Q
L
K
E
V
V
S
K
A
E
Q
L
Q
Q
Q
V
R
E
L
Q
K
E
N
E
Q
L
A
S
K
L
ANQQAGDVFKDPETING
K
T
I
I
A
A
Q
V
K
V
K
D
M
N
Q
L
R
Q
L
A
D
Q
W
K
QKNI
S
D
I
L
V
L
ANEQEGK
V
S
L
L
A
A
M
T
KESNEAGL
K
A
G
D
L
I
K
A
I
A
PKVGGGGGGR
P
D
M
A
QAGGKNPAG
I
P
D
A
L
K
A
A
K
E
W
VAQQ
18
PsiBlast_PDB
75.94
26%
34
* C1 *
-
3WQY
1
SYA_ARCFU
A:
[64-883]
-------
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
-
I
A
D
F
Q
P
F
V
T
S
G
-
V
A
P
PP
A
-----
N
P
------
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
---------------------------------------------
E
L
G
V
K
K
E
D
I
--
V
--
Y
K
---------
E
E
P
W
A
G
G
G
N
A
G
P
C
------------------------
L
E
A
I
V
G
G
-----
L
E
V
A
T
L
V
F
M
N
L
E
E
H
P
E
G
-------
D
I
E
IKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
GTPT
V
Y
D
A
I
F
P
E
V
V
D
T
I
I
D
N
S
N
V
S
F
NR
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
RG
E
R
L
N
Q
L
R
K
S
V
------
A
-----------------------------------------------
D
T
V
-----------
G
V
S
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
-
E
-
E
L
EL
G
L
D
---
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
D
V
P
L
S
T
---
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
E
R
K
K
K
-----
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
------
E
M
P
K
D
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
---
V
Q
E
K
K
I
T
----
L
Q
N
E
Y
P
A
T
E
K
L
---
Y
Y
D
D
P
T
L
L
E
F
E
A
E
V
I
---
G
V
E
G
D
F
-
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
--
V
V
D
V
L
E
A
-
D
G
V
V
L
H
V
V
K
G
A
K
P
-
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
-
F
G
F
R
L
Y
QG
G
V
P
P
G
-
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
-
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
A
-
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
G
A
--
V
G
C
L
M
A
K
G
E
G
K
V
F
V
V
T
F
S
G
Q
K
Y
D
-----
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
---------------------
42
HHSearch
74.04
50%
23
- C1 -
-
3HY0
4
SYA_ECOLI
A:
[1-439]
--
S
K
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
-
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
-
D
K
R
--
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
--------
E
S
D
--------
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
--
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
---
G
D
H
I
W
----
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
-------
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
-------------------
A
V
L
Q
H
V
N
S
N
Y
--
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
-----------
G
-
A
T
---------------------------------------------------------
D
L
S
-----------
N
K
S
L
R
-------------
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
73.87
26%
40
- C1 -
-
3WQZ
1
SYA_ARCFU
A:
[64-883]
-------
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
-
I
A
D
F
Q
P
F
V
T
S
G
-
V
A
P
PP
A
-----
N
P
------
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
---------------------------------------------
E
L
G
V
K
K
E
D
I
--
V
--
Y
K
---------
E
E
P
W
A
G
G
G
N
A
G
P
C
------------------------
L
E
A
I
V
G
G
-----
L
E
V
A
T
L
V
F
M
N
L
E
E
H
P
E
G
-------
D
I
E
IKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
GTPT
V
Y
D
A
I
F
P
E
V
V
D
T
I
I
D
N
S
N
V
S
F
NR
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
RGER
L
N
Q
L
R
K
S
V
------
A
-----------------------------------------------
D
T
V
-----------
G
V
S
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
-
E
-
E
L
EL
G
L
D
---
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
D
V
P
L
S
T
---
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
E
R
K
K
K
-----
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
------
E
M
P
K
D
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
---
V
Q
E
K
K
I
T
----
L
Q
N
E
Y
P
A
T
E
K
L
---
Y
Y
D
D
P
T
L
L
E
F
E
A
E
V
I
---
G
V
E
G
D
F
-
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
--
V
V
D
V
L
E
A
-
D
G
V
V
L
H
V
V
K
G
A
K
P
-
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
-
F
G
F
R
L
Y
QG
G
V
P
P
G
-
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
-
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
A
-
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
G
A
--
V
G
C
L
M
A
K
G
E
G
K
V
F
V
V
T
F
S
G
Q
K
Y
D
-----
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
---------------------
43
HHSearch
73.73
50%
23
- C1 -
-
3HXZ
6
SYA_ECOLI
B:
[1-439]
--
S
K
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
-
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
-
D
K
R
--
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
--------
E
S
D
--------
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
--
I
--
R
I
GDNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
---
G
D
H
I
W
----
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
-------
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
-------------------
A
V
L
Q
H
V
N
S
N
Y
--
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
-----------
G
-
A
T
---------------------------------------------------------
D
L
S
-----------
N
K
S
L
R
-------------
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.11
48%
7
- C1 -
-
1RIQ
-
SYA_AQUAE
A:
[2-453]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
-
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
-
E
K
R
--
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
--------
K
D
D
--------
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
--
G
E
---------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
---
G
E
E
Y
E
G
-------------
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
-------
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
-------------------
S
V
L
Q
G
K
N
S
N
F
--
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
-----------
G
K
-
K
Y
G
E
------
K
-----------------------------------------------
F
E
T
-----------
D
V
A
L
R
-------------
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
V
Y
S
H
L
K
E
L
G
-
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
72.09
48%
21
- C1 -
-
3HXY
3
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
-
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
-
D
K
R
--
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
--------
E
S
D
--------
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
--
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
---
G
----
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
-------
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
-------------------
A
V
L
Q
H
V
N
S
N
Y
--
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
----------------
G
A
------
T
-----------------------------------------------
D
L
S
-----------
N
K
S
L
R
-------------
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.90
48%
24
- C1 -
-
3HXX
1
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
-
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
-
D
K
R
--
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
--------
E
S
D
--------
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
--
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
---
G
----
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
-------
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
-------------------
A
V
L
Q
H
V
N
S
N
Y
--
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
----------------
G
A
------
T
-----------------------------------------------
D
L
S
-----------
N
K
S
L
R
-------------
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.79
48%
20
- C1 -
-
3HY1
2
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
-
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
-
D
K
R
--
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
--------
E
S
D
--------
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
--
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
---
G
----
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
-------
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
-------------------
A
V
L
Q
H
V
N
S
N
Y
--
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
----------------
G
A
------
T
-----------------------------------------------
D
L
S
-----------
N
K
S
L
R
-------------
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
71.69
28%
17
- C1 -
-
2ZTG
1
SYA_ARCFU
A:
[58-739]
-
K
P
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
-
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
G
V
A
P
P
--
P
-----
A
N
-----
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
---
E
L
G
V
K
K
E
D
I
V
----------------------------------
Y
----------------------
K
E
E
P
W
A
-
G
-
G
G
N
A
G
P
C
L
E
A
I
V
G
--------------------------
G
L
E
V
A
T
L
V
F
M
N
L
E
E
H
P
E
G
DIEIKG
A
R
Y
R
-------
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
-------------------
W
A
S
K
G
T
P
T
V
Y
--
D
A
-
I
F
P
E
V
V
D
T
I
I
D
N
S
-----------
N
-
V
S
F
N
R
------
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
GIMGELRGERL
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
-----------
L
E
K
V
Y
-------------
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
-
E
-
E
L
--
E
L
G
-
L
D
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
---
E
F
D
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
E
R
-----
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
K
D
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
Q
E
K
K
I
------
T
L
Q
N
E
Y
P
A
T
E
--
K
L
Y
Y
D
D
P
TLL
E
F
E
A
E
V
I
G
V
E
------------
G
D
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
--
G
K
F
E
V
V
D
V
L
E
A
D
-
G
V
V
L
H
V
V
K
G
-
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
R
L
Y
Q
--
G
G
V
P
P
G
R
K
I
R
V
V
Q
V
G
-
D
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.63
48%
26
- C1 -
-
3HY0
4
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
-
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
-
D
K
R
--
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
--------
E
S
D
--------
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
--
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
---
G
----
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
-------
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
-------------------
A
V
L
Q
H
V
N
S
N
Y
--
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
----------------
G
A
------
T
-----------------------------------------------
D
L
S
-----------
N
K
S
L
R
-------------
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.63
48%
5
- C1 -
-
1YFS
1
SYA_AQUAE
A:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
-
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
-
E
K
R
--
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
--------
K
D
D
--------
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
--
G
E
---------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
---
G
E
E
Y
E
G
-------------
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
-------
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
-------------------
S
V
L
Q
G
K
N
S
N
F
--
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
-----------
G
K
-
K
Y
G
E
------
K
-----------------------------------------------
F
E
T
-----------
D
V
A
L
R
-------------
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
V
Y
S
H
L
K
E
L
G
-
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
71.52
48%
5
- C1 -
-
1YFR
1
SYA_AQUAE
A:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
-
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
-
E
K
R
--
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
--------
K
D
D
--------
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
--
G
E
---------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
---
G
E
E
Y
E
G
-------------
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
-------
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
-------------------
S
V
L
Q
G
K
N
S
N
F
--
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
-----------
G
K
-
K
Y
G
E
------
K
-----------------------------------------------
F
E
T
-----------
D
V
A
L
R
-------------
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
V
Y
S
H
L
K
E
L
G
-
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.51
48%
25
- C1 -
-
3HXZ
6
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
-
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
-
D
K
R
--
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
--------
E
S
D
--------
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
--
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
---
G
----
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
-------
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
-------------------
A
V
L
Q
H
V
N
S
N
Y
--
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
----------------
G
A
------
T
-----------------------------------------------
D
L
S
-----------
N
K
S
L
R
-------------
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
71.48
48%
9
- C1 -
-
1YFS
1
SYA_AQUAE
B:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
-
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
-
E
K
R
--
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
--------
K
D
D
--------
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
WR
L
--
G
E
---------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
---
G
E
E
Y
E
G
-------------
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
-------
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
-------------------
S
V
L
Q
G
K
N
S
N
F
--
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
-----------
G
K
-
K
Y
G
E
------
K
-----------------------------------------------
F
E
T
-----------
D
V
A
L
R
-------------
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
V
Y
S
H
L
K
E
L
G
-
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
71.43
48%
5
- C1 -
-
3HTZ
-
SYA_AQUAE
A:
[2-453]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
-
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
-
E
K
R
--
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
--------
K
D
D
--------
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
--
G
E
---------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
---
G
E
E
Y
E
G
-------------
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
-------
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
-------------------
S
V
L
Q
G
K
N
S
N
F
--
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
-----------
G
K
-
K
Y
G
E
------
K
-----------------------------------------------
F
E
T
-----------
D
V
A
L
R
-------------
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
---------
K
P
V
Y
S
H
L
K
E
L
G
-
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.41
48%
24
- C1 -
-
3HXU
5
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
-
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
-
D
K
R
--
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
--------
E
S
D
--------
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
--
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
---
G
----
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
-------
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
-------------------
A
V
L
Q
H
V
N
S
N
Y
--
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
----------------
G
A
------
T
-----------------------------------------------
D
L
S
-----------
N
K
S
L
R
-------------
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
71.32
48%
25
- C1 -
-
3HXV
6
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
-
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
-
D
K
R
--
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
--------
E
S
D
--------
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
--
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
---
G
----
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
-------
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
-------------------
A
V
L
Q
H
V
N
S
N
Y
--
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
----------------
G
A
------
T
-----------------------------------------------
D
L
S
-----------
N
K
S
L
R
-------------
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.26
48%
26
- C1 -
-
3HXW
5
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
-
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
-
D
K
R
--
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
--------
E
S
D
--------
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
--
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
---
G
----
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
-------
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
-------------------
A
V
L
Q
H
V
N
S
N
Y
--
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
----------------
G
A
------
T
-----------------------------------------------
D
L
S
-----------
N
K
S
L
R
-------------
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.22
48%
8
- C1 -
-
1YFR
1
SYA_AQUAE
B:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
-
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
-
E
K
R
--
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
--------
K
D
D
--------
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
WR
L
--
G
E
---------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
---
G
E
E
Y
E
G
-------------
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
-------
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
-------------------
S
V
L
Q
G
K
N
S
N
F
--
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
-----------
G
K
-
K
Y
G
E
------
K
-----------------------------------------------
F
E
T
-----------
D
V
A
L
R
-------------
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
V
Y
S
H
L
K
E
L
G
-
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
71.15
48%
26
- C1 -
-
3HXZ
6
SYA_ECOLI
B:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
-
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
-
D
K
R
--
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
--------
E
S
D
--------
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
--
I
--
R
I
GDNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
---
G
----
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
-------
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
-------------------
A
V
L
Q
H
V
N
S
N
Y
--
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
----------------
G
A
------
T
-----------------------------------------------
D
L
S
-----------
N
K
S
L
R
-------------
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.06
48%
7
- C1 -
-
1YGB
1
SYA_AQUAE
A:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
-
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
-
E
K
R
--
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
--------
K
D
D
--------
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
--
G
E
---------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
---
G
E
E
Y
E
G
-------------
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
-------
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
-------------------
S
V
L
Q
G
K
N
S
N
F
--
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
-----------
G
K
-
K
Y
G
E
------
K
-----------------------------------------------
F
E
T
-----------
D
V
A
L
R
-------------
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
V
Y
S
H
L
K
E
L
G
-
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.01
48%
11
- C1 -
-
1YFT
1
SYA_AQUAE
A:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
-
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
-
E
K
R
--
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
--------
K
D
D
--------
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
--
G
E
---------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
---
G
E
E
Y
E
G
-------------
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
-------
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
-------------------
S
V
L
Q
G
K
N
S
N
F
--
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
-----------
G
K
-
K
Y
G
E
------
K
-----------------------------------------------
F
E
T
-----------
D
V
A
L
R
-------------
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
V
Y
S
H
L
K
E
L
G
-
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
70.95
48%
26
- C1 -
-
3HY0
4
SYA_ECOLI
B:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
-
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
-
D
K
R
--
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
--------
E
S
D
--------
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
--
I
--
R
I
GDNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
---
G
----
D
H
I
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
-------
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
-------------------
A
V
L
Q
H
V
N
S
N
Y
--
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
----------------
G
A
------
T
-----------------------------------------------
D
L
S
-----------
N
K
S
L
R
-------------
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
---
E
E
L
A
K
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.10
40%
26
- C1 -
-
4XEO
3
SYAC_HUMAN
A:
[25-408]
---
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
-
T
Y
V
H
S
S
A
T
I
P
L
D
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
T
-
I
D
P
--
S
-----
H
P
MAKLS
R
A
A
N
T
Q
K
C
I
R
A
GGKH
N
-
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
-----
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
--
Q
E
F
G
I
P
I
E
R
L
Y
V
T
Y
F
GGDEAAGL
E
A
D
--------
L
E
C
K
Q
I
W
-
Q
N
L
G
L
D
D
T
K
I
--
L
P
G
N
M
---------
K
D
N
F
W
E
M
G
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
IGG
R
D
A
A
H
L
V
N
Q
D
D
P
N
---------
V
L
E
I
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
-------
I
L
K
-------
P
L
P
K
K
S
I
D
T
G
M
G
L
E
R
L
V
-------------------
S
V
L
Q
N
K
M
S
N
Y
--
D
T
D
L
F
V
P
Y
F
E
A
I
Q
K
G
T
----------------
G
A
------
R
-----------------------------------------------
P
Y
T
GKVGAEDADG
I
D
M
A
Y
R
-------------
V
L
A
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
H
R
A
V
R
Y
A
H
E
-
K
L
--
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
T
L
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.97
41%
20
- C1 -
-
4XEM
6
SYAC_HUMAN
A:
[25-404]
---
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
-
T
Y
V
H
S
S
A
T
I
P
L
D
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
T
-
I
D
P
--
S
-----
H
P
MAKLS
R
A
A
N
T
Q
K
C
I
R
A
G----
D
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
-----
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
--
Q
E
F
G
I
P
I
E
R
L
Y
V
T
Y
F
GGDEAAGL
E
A
D
--------
L
E
C
K
Q
I
W
-
Q
N
L
G
L
D
D
T
K
I
--
L
P
G
N
M
---------
K
D
N
F
W
E
M
G
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
IGG
R
D
A
A
H
L
V
N
Q
D
D
P
N
---------
V
L
E
I
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
-------
I
L
K
-------
P
L
P
K
K
S
I
D
T
G
M
G
L
E
R
L
V
-------------------
S
V
L
Q
N
K
M
S
N
Y
--
D
T
D
L
F
V
P
Y
F
E
A
I
Q
K
G
T
----------------
G
A
------
R
-----------------------------------------------
P
Y
T
GKVGAEDADG
I
D
M
A
Y
R
-------------
V
L
A
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
R
R
A
V
R
Y
A
H
E
-
K
L
--
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
61.47
40%
14
- C1 -
-
4XEO
5
SYAC_HUMAN
B:
[25-405]
---
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
-
T
Y
V
H
S
S
A
T
I
P
L
D
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
T
-
I
D
P
--
S
-----
H
P
MAKLS
R
A
A
N
T
Q
K
C
I
R
A
-----
D
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
-----
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
--
Q
E
F
G
I
P
I
E
R
L
Y
V
T
Y
F
GGDEAAGL
E
A
D
--------
L
E
C
K
Q
I
W
-
Q
N
L
G
L
D
D
T
K
I
--
L
P
G
N
M
---------
K
D
N
F
W
E
M
G
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
IGG
R
D
A
A
H
L
V
N
Q
D
D
P
N
---------
V
L
E
I
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
-------
I
L
K
-------
P
L
P
K
K
S
I
D
T
G
M
G
L
E
R
L
V
-------------------
S
V
L
Q
N
K
M
S
N
Y
--
D
T
D
L
F
V
P
Y
F
E
A
I
Q
K
G
T
----------------
G
A
------
R
-----------------------------------------------
P
Y
T
GKVGAEDADG
I
D
M
A
Y
R
-------------
V
L
A
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
H
R
A
V
R
Y
A
H
E
-
K
L
--
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
61.42
43%
29
- C1 -
-
4XEM
6
SYAC_HUMAN
A:
[24-404]
--
T
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
-
T
Y
V
H
S
S
A
T
I
P
L
D
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
T
-
I
D
P
--
S
HPMAK
L
S
-----
R
A
A
N
T
Q
K
C
I
R
A
G----
D
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
-----
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
--
Q
E
F
G
I
P
I
E
R
L
Y
V
T
Y
F
--------
G
G
D
EAAGLEAD
L
E
C
K
Q
I
W
Q
N
-
L
G
L
D
D
T
K
I
--
L
--
P
G
N
M-------
K
D
N
F
W
E
M
G
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
---
I
G
G
R
-----
D
A
-
A
H
L
V
N
Q
D
D
P
N
V
L
E
I
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
-------
I
L
K
-------
P
L
P
K
K
S
I
D
T
G
M
G
L
E
R
L
V
-------------------
S
V
L
Q
N
K
M
S
N
Y
--
D
T
D
L
F
V
P
Y
F
E
A
I
Q
K
G
T
-----------
G
A
R
P
Y
T
G
KVGAED
A
-----------------------------------------------
D
G
I
-----------
D
M
A
Y
R
-------------
V
L
A
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
R
R
A
V
R
Y
A
-
H
E
K
L
--
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------