@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U2J5: (2017-12-22 )
MLLMSSKAELLNGMNPRQKEAVLHTDGPLLLMAGAGSGKTRVLTHRIAYLIEEKEVNPWNILAITFTNKAAKEMKERVNAILASGGEDVWVSTFHSMCVRILRRDVDFIGYNRNFTIIDSSEQLTLMKRILKELNIDPKKYDPRSILGTISQAKNSLQTPQDFAKMQGSYYEEIAAKCYAAYQKEFQYNQCMDFDDLIMNTIRLFEEHPDSLTYYQNKFHYIHVDEYQDTNHAQYTLVNLLAGRFRNLCVVGDADQSIYGWRGADMQNILDFEKDYPDAAVILLEQNYRSTKNILSAANQVIENNSNRKPKNLWTENKEGNKITYYRADNERDETRFIVDRMQEEIRSNHRNYGDFAILYRTNAQSRVMEETLLKANIPYKMVGGHKFYDRKEIKDILAYLNVLVNPQDSISFERIVNSPKRGIGPGSIEKLRSFASLHEWPLLEAAQNVDLANIGGKAGQQLGAFGEMIQEVTQMIPYLTVTELTKEVLDRSGYLEDLKIQNTLEAQARIENLEEFLTVTQEFDKQFEQQNEEDADAPEEKLTVFLNDLALVSDIDNLEEDASQVTLMTLHAAKGLEFPVVFLIGLEEGVFPLSRALMEESELEEERRLAYVGITRAEEALYLTNAFSRTLYGRTQYNRPSRFVEEIDQELLEIEGMRPTPKKTPVFAKKTAYSYKQPETAVVPSKSATGGENNSWKPGDKVKHKKWGLGTVVRVSGTSKDLELDVAFPSQGVKRLLAAFAPIEKA
Atome Classification :
(22 SA)
.........10........20........30........40........50...--.....60........70........80...-.----------------....90........100.......110.......120.......130.....-----------------------------------------..140.....-------------------------..150..-----------------------------------------------------------.....160.------..--------..---------------.------.170----.......180.......190.......200......--------.210.......220.......230.......240..---.....250.......260.......270.....-----..280.......290.......300.......310--------..--..--...320-------.......330.......340......------------.350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......-450.-.-......460.......470.....---..480.......490.......500.--......510.......520.......530.......540.......550.....-------.---.560....-------....570.......580.......590......-----------------------------------.-600........610.......620.......630.......640.......650.......660-........670.......680.......690.......700.......710.......720.......730.......740.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLLMS
S
K
A
E
L
LNGMNP
R
Q
K
E
A
V
LHTDG
P
L
L
L
M
A
GAGSGKT
R
V
L
T
H
R
I
A
Y
L
I
E
EK--EVNP
W
N
I
L
A
I
T
FT
N
K
A
A
K
E
M
K
E
R
V
N
A
I
L
AS-G----------------GE
D
V
W
V
S
T
F
H
S
M
C
V
R
I
L
R
RDV
D
F
IGYNR
N
F
T
I
IDS
S
E
Q
L
T
L
M
K
R
I
L
K
ELNID-----------------------------------------PKKY
D
P
R
S
I
L
-------------------------
G
T
I
S
Q
A
K-----------------------------------------------------------NSLQ
T
P
Q
D
F
------
A
K
--------
M
Q
---------------
G
------
S
Y
Y
E
----
E
I
A
A
K
C
Y
A
A
Y
Q
K
EFQYNQCM
D
F
D
D
L
I
M
N
T
I
R
L
F
E
EH--------PDSL
T
Y
YQ
N
K
F
H
Y
I
H
VDEYQDTNH
A
Q
Y
T
L
V
N
L
L
A
G
R
---
F
R
N
L
C
V
VGDADQSIYGWRGA
D
M
Q
N
I
L
D
F
EKDYP-----D
A
A
V
I
L
L
EQNY
R
S
T
K
N
I
L
S
A
A
N
Q
V
I
ENNSNRKPKN--------LW--TE--NKEG
N
K
-------
I
T
Y
Y
RADNER
D
E
T
R
F
I
V
D
R
M
Q
E
E
I
R
S------------NHRNYG
D
F
A
I
L
Y
RTNA
Q
S
R
V
M
E
E
T
L
L
KANI
P
Y
K
MVGGHKFY
D
R
K
E
I
K
D
I
L
A
Y
L
N
V
LVNPQDS
I
S
F
E
R
I
VNSPKRGIG
P
G
S
I
E
K
L
R
S
F
A
S
L
H
EW
P
L
L
E
A
AQN-VD-L-A-NIG
G
K
A
G
Q
Q
L
G
A
F
G
E
M
I
Q
E
V
T
Q
MI---P
Y
L
T
V
T
E
L
T
K
E
V
L
DRSGY
L
E
D
L
K
I
Q
N
--
T
L
E
A
Q
A
R
I
E
N
L
E
E
F
L
T
V
T
Q
E
F
D
K
Q
F
E
QQNEEDADA
P
E
E
K
L
T
V
F
L
N
D
L
A
L
V
S
D
I
D
-------
N
---
L
E
-
E
D
A
S
Q
-------
V
T
L
M
T
L
HAAKGLEF
P
V
V
F
L
I
GLEEG
V
F
P
L
S
R
A
L
-----------------------------------
M
-
E
-
E
S
E
L
E
E
ER
R
L
A
Y
V
G
ITRAE
E
A
L
Y
L
T
N
A
F
S
R
T
LYGRTQYN
R
P
S
R
F
V
E
E
I
D
Q
E
L
L
E
IEGMRPT--PKKTP
V
F
A
KKTAYSYKQPE
T
A
VVPSKSATGGENNSWKPGDKVKHKKWG
L
G
T
V
V
R
VSGTSK
D
L
E
L
D
V
AF
P
S
Q
G
V
K
R
L
L
A
A
FAPIEKA
1
PsiBlast_PDB
92.68
59%
-68
- C2 -
-
3PJR
2
?
A:
[7-652]
--------
Q
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
G
-
A
----------------
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
K
N
I
D
-----------------------------------------
P
K
K
F
E
P
R
T
I
L
-------------------------
G
T
I
S
A
A
K
-----------------------------------------------------------
N
E
L
L
P
P
E
Q
F
------
A
K
--------
R
A
---------------
S
------
T
Y
Y
E
----
K
V
V
S
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
--------
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
--------
I
W
--
T
E
--
N
P
E
G
K
P
-------
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
------------
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
-
L
E
-
M
-
I
-
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
---
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
--
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
------
E
N
V
S
D
----
D
K
S
L
I
A
F
L
T
D
L
A
L
I
S
D
L
D
-------
E
-----T
E
Q
A
A
E
G
D
A
----
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
-----------------------------------
E
-
D
-
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
T
A
S
R
R
------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.06
59%
-65
- C2 -
-
1QHG
1
PCRA_GEOSE
A:
[7-651]
--------
Q
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
-
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
G
-
A
----------------
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
K
N
I
D
-----------------------------------------
P
K
K
F
E
P
R
T
I
L
-------------------------
G
T
I
S
A
A
K
-----------------------------------------------------------
N
E
L
L
P
P
E
Q
F
------
A
K
--------
R
------------------------
Y
Y
E
----
K
V
V
S
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
--------
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
--------
I
W
--
T
E
--
N
P
E
G
K
P
-------
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
------------
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
------------
L
F
E
A
L
G
E
-
L
E
-
M
-
I
-
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
---
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
--
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
------
E
N
V
S
D
----
D
K
S
L
I
A
F
L
T
D
L
A
L
I
S
----------------------GD
A
----
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
-----------------------------------
E
-
D
-
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
T
A
S
R
-------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.84
59%
-62
- C2 -
-
1PJR
-
PCRA_GEOSE
A:
[7-651]
--------
Q
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
G
-
A
----------------
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
K
N
I
D
-----------------------------------------
P
K
K
F
E
P
R
T
I
L
-------------------------
G
T
I
S
A
A
K
-----------------------------------------------------------
N
E
L
L
P
P
E
Q
F
------
A
K
--------
R
------------------------
Y
Y
E
----
K
V
V
S
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
--------
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
--------
I
W
--
T
E
--
N
P
E
G
K
P
-------
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
------------
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
------------
L
F
E
A
L
G
E
-
L
E
-
M
-
I
-
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
---
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
--
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
------
E
N
V
S
D
----
D
K
S
L
I
A
F
L
T
D
L
A
L
I
S
----------------------GD
A
----
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
-----------------------------------
E
-
D
-
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
T
A
S
R
-------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.68
62%
-94
- C2 -
-
2PJR
1
?
A:
[7-548]
--------
Q
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
G
-
A
----------------
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
K
N
I
D
-----------------------------------------
P
K
K
F
E
P
R
T
I
L
-------------------------
G
T
I
S
A
A
K
-----------------------------------------------------------
N
E
L
L
P
P
E
Q
F
------
A
K
--------
R
A
---------------
S
------
T
Y
Y
E
----
K
V
V
S
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
--------
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
--------
I
W
--
T
E
--
N
P
E
G
K
P
-------
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
------------
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
-
L
E
-
M
-
I
-
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
---
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
--
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
------
E
N
V
S
D
----
D
K
S
L
I
A
F
L
T
D
L
A
L
I
S
D
L
D
-------
E
---
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.05
62%
-91
- C2 -
-
2PJR
2
?
F:
[7-547]
--------
Q
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
G
-
A
----------------
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
K
N
I
D
-----------------------------------------
P
K
K
F
E
P
R
T
I
L
-------------------------
G
T
I
S
A
A
K
-----------------------------------------------------------
N
E
L
L
P
P
E
Q
F
------
A
K
--------
R
A
---------------
S
------
T
Y
Y
E
----
K
V
V
S
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
--------
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
--------
I
W
--
T
E
--
N
P
E
G
K
P
-------
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
------------
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
-
L
E
-
M
-
I
-
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
---
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
--
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
------
E
N
V
S
D
----
D
K
S
L
I
A
F
L
T
D
L
A
L
I
S
D
L
D
-------
E
---
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.98
42%
-55
- C2 -
-
2IS1
4
UVRD_ECOLI
A:
[6-653]
---------
L
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
--
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
T
-
S
----------------
Q
G
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
P
Q
D
F
Q
I
L
D
S
E
D
Q
L
R
L
L
K
R
L
I
K
A
M
N
L
D
-----------------------------------------
E
K
Q
W
P
P
R
Q
A
M
-------------------------
W
Y
I
N
S
Q
K
-----------------------------------------------------------
D
E
G
L
R
P
H
H
I
-------
Q
--------
S
Y
---------------
G
------
N
P
V
E
----
Q
T
W
Q
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
--------
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
--------
L
W
--
T
D
--
G
A
D
G
E
P
-------
I
S
L
Y
C
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
-
T
W
Q
D
------------
N
G
G
A
L
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
L
Q
-
E
-
K
-
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
T
---
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
E
Q
E
K
--
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
S
Y
-----
N
---
E
D
L
M
--
P
L
Q
A
F
L
S
H
A
A
L
E
A
G
E
G
-------
Q
---
A
D
-
T
W
Q
D
A
-------
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
S
L
-----------------------------------
D
-
E
-
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
P
E
E
C
V
E
E
V
R
L
R
A
T
--
V
S
R
-
P
---------------------------------------------------------------------------------
8
PsiBlast_PDB
86.75
42%
-47
- C2 -
-
2IS6
5
UVRD_ECOLI
A:
[6-656]
---------
L
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
--
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
T
-
S
----------------
Q
G
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
P
Q
D
F
Q
I
L
D
S
E
D
Q
L
R
L
L
K
R
L
I
K
A
M
N
L
D
-----------------------------------------
E
K
Q
W
P
P
R
Q
A
M
-------------------------
W
Y
I
N
S
Q
K
-----------------------------------------------------------
D
E
G
L
R
P
H
H
I
-------
Q
--------
S
Y
---------------
G
------
N
P
V
E
----
Q
T
W
Q
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
--------
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
--------
L
W
--
T
D
--
G
A
D
G
E
P
-------
I
S
L
Y
C
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
-
T
W
Q
D
------------
N
G
G
A
L
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
L
Q
-
E
-
K
-
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
T
---
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
E
Q
E
K
--
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
S
Y
-----
N
E
E
--
D
L
M
--
P
L
Q
A
F
L
S
H
A
A
L
E
A
G
E
G
-------
Q
---
A
D
-
T
W
Q
D
A
-------
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
S
L
-----------------------------------
D
-
E
-
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
P
E
E
C
V
E
E
V
R
L
R
A
T
--
V
S
R
-
P
V
-------
S
H
-----------------------------------------------------------------------
7
PsiBlast_PDB
85.29
42%
-54
- C2 -
-
2IS2
2
UVRD_ECOLI
A:
[6-646]
---------
L
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
--
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
T
-
S
----------------
Q
G
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
P
Q
D
F
Q
I
L
D
S
E
D
Q
L
R
L
L
K
R
L
I
K
A
M
N
L
D
-----------------------------------------
E
K
Q
W
P
P
R
Q
A
M
-------------------------
W
Y
I
N
S
Q
K
-----------------------------------------------------------
D
E
G
L
R
P
H
H
I
-------
Q
--------
S
Y
---------------
G
------
N
P
V
E
----
Q
T
W
Q
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
--------
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
--------
L
W
--
T
D
--
G
A
D
G
E
P
-------
I
S
L
Y
C
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
-
T
W
Q
D
------------
N
G
G
A
L
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
L
Q
-
E
-
K
-
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
T
---
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
E
Q
E
K
--
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
S
Y
--------
D
E
D
L
M
--
P
L
Q
A
F
L
S
H
A
A
L
E
A
G
E
G
-------
Q
---
A
D
-
T
W
Q
D
A
-------
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
S
L
-----------------------------------
D
-
E
-
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
P
E
E
C
V
E
E
V
R
L
-------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.18
42%
-55
- C2 -
-
2IS1
4
UVRD_ECOLI
B:
[6-644]
---------
L
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
--
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
T
-
S
----------------
Q
G
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
P
Q
D
F
Q
I
L
D
S
E
D
Q
L
R
L
L
K
R
L
I
K
A
M
N
L
D
-----------------------------------------
E
K
Q
W
P
P
R
Q
A
M
-------------------------
W
Y
I
N
S
Q
K
-----------------------------------------------------------
D
E
G
L
R
P
H
H
I
-------
Q
--------
S
-------------------------
V
E
----
Q
T
W
Q
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
--------
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
--------
L
W
--
T
D
--
G
A
D
G
E
P
-------
I
S
L
Y
C
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
-
T
W
Q
D
------------
N
G
G
A
L
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
L
Q
-
E
-
K
-
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
T
---
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
E
Q
E
K
--
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
S
Y
--------
D
E
D
L
M
--
P
L
Q
A
F
L
S
H
A
A
L
E
A
G
E
G
----------------
Q
D
A
-------
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
-------------------------------------------
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
P
E
E
C
V
E
E
V
---------------------------------------------------------------------------------------------
35
HHSearch
82.57
45%
-2
- C2 -
-
4C2U
2
?
A:
[5-655]
-----
A
G
P
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
------------------
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
--------------------------------------------
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
A
K
-----------------------------------------------------------
S
N
L
W
T
P
D
D
L
------
D
R
--------
S
R
EPFI-----------
S
------
G
L
P
R
----
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
G
E
-------------
G
R
A
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
-
A
A
-
E
-
Q
-
N
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
---
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
G
---
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
Q
D
E
A
--------
N
V
G
G
S
I
A
D
F
L
D
D
A
A
L
L
S
S
V
D
D
M
R
T
K
A
E
N
---
K
G
-
A
P
E
D
A
-------
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
-----------------------------------
A
E
G
-
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
T
V
----------------------------------------------------------------------------------------------
27
PsiBlast_CBE
82.41
44%
-3
- C2 -
-
4C2U
2
?
D:
[4-649]
----
S
A
G
P
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
-
A
----------------
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
--------------------------------------------
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
A
K
-----------------------------------------------------------
S
N
L
W
T
P
D
D
L
------
D
R
--------
S
R
---------------
E
------
P
F
I
S
GLPR
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
-
R
L
H
G
------------
E
G
R
A
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
-
A
A
-
E
-
Q
-
N
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
---
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
-
D
L
L
R
Q
E
--
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
-----
S
Q
D
E
A
N
V
G
G
---
S
I
A
D
F
L
D
D
A
A
L
L
S
S
V
D
-------
D
---
M
R
-
T
K
A
E
N
KGAPEDA
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
-----------------------------------
A
-
E
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
----------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.15
42%
-3
- C2 -
-
4C2T
1
?
C:
[4-662]
----
S
A
G
P
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
-
A
----------------
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
I
-----------------------------------------
G
A
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
A
K
-----------------------------------------------------------
S
N
L
W
T
P
D
D
L
------
D
R
--------
S
R
---------------
E
------
P
F
I
S
GLP
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
-
R
L
H
G
------------
E
G
R
A
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
-
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
-
A
A
-
E
-
Q
-
N
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
---
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
-
D
L
L
R
Q
E
----
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
-----
S
Q
D
E
A
N
------
S
I
A
D
F
L
D
D
A
A
L
L
S
S
V
D
-------
D
---
M
R
-
T
K
A
E
-PED
A
---
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
-----------------------------------
A
-
E
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
-------
D
I
E
G
L
F
D
T
V
D
P
Y
G
Q
P
I
--------------------------------------------------------------------------------
9
PsiBlast_PDB
81.94
44%
-4
- C2 -
-
4C2U
2
?
A:
[4-649]
----
S
A
G
P
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
-
A
----------------
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
--------------------------------------------
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
A
K
-----------------------------------------------------------
S
N
L
W
T
P
D
D
L
------
D
R
--------
S
R
---------------
E
------
P
F
I
S
GLP
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
-
R
L
H
G
------------
E
G
R
A
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
-
A
A
-
E
-
Q
-
N
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
---
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
-
D
L
L
R
Q
E
--
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
-----
S
Q
D
E
A
N
V
G
G
---
S
I
A
D
F
L
D
D
A
A
L
L
S
S
V
D
-------
D
---
M
R
-
T
K
A
E
N
KGAPED
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
-----------------------------------
A
-
E
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
----------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.62
42%
-5
- C2 -
-
4C2T
1
?
A:
[5-662]
-----
A
G
P
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
-
A
----------------
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
I
-----------------------------------------
G
A
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
A
K
-----------------------------------------------------------
S
N
L
W
T
P
D
D
L
------
D
R
--------
S
R
---------------
E
------
P
F
I
S
GLP
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
-
R
L
H
G
------------
E
G
R
A
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
-
A
A
-
E
-
Q
-
N
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
---
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
-
D
L
L
R
Q
E
--
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
-----
S
Q
D
E
A
N
V
G
G
---
S
I
A
D
F
L
D
D
A
A
L
L
S
S
---------
D
---
M
R
-
T
K
A
--ED
A
----
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
-----------------------------------
A
-
E
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
-------
D
I
E
G
L
F
D
T
V
D
P
Y
G
Q
P
I
--------------------------------------------------------------------------------
10
PsiBlast_PDB
81.14
44%
18
- C2 -
-
4C30
1
?
A:
[7-649]
-------
P
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
-
A
----------------
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
I
-----------------------------------------
G
A
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
A
K
-----------------------------------------------------------
S
N
L
W
T
P
D
D
L
------
D
R
--------
S
R
---------------
E
------
P
---P
R
--
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
-
R
L
H
G
------------
E
G
R
A
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
--------------
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
---
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
-
D
L
L
R
Q
E
--
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
-----
S
Q
D
E
A
--------
I
A
D
F
L
D
D
A
A
L
L
S
S
V
D
-------
D
---
M
R
-
T
K
A
E
-PED
A
---
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
-----------------------------------
A
-
E
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
----------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
79.99
44%
18
- C2 -
-
4C30
1
?
F:
[7-649]
-------
P
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
-
A
----------------
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
I
-----------------------------------------
G
A
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
A
K
-----------------------------------------------------------
S
N
L
W
T
P
D
D
L
------
D
R
--------
S
R
---------------
E
------
P
---PR--
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
-
R
L
H
G
------------
E
G
R
A
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
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L
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A
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G
G
V
G
F
Y
D
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R
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I
R
D
I
L
A
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A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
--------------
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
---
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
-
D
L
L
R
Q
E
--
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
-----
S
Q
D
E
A
--------
I
A
D
F
L
D
D
A
A
L
L
S
S
V
D
-------
D
---
M
R
-
T
K
A
E
-PEDA---
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
-----------------------------------
A
-
E
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
----------------------------------------------------------------------------------------------------
33
HHSearch
75.27
40%
9
- C2 -
-
1UAA
1
REP_ECOLI
A:
[2-640]
------------
R
L
N
P
G
Q
Q
Q
A
V
E
F
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
C
--
G
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
L
G
R
K
E
----------------
A
R
G
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
A
N
F
S
L
F
D
D
T
D
Q
L
A
L
L
K
E
L
T
E
G
L
I
E
D
-----------------------------------------
D
K
V
L
-
L
Q
Q
L
I
-------------------------
S
T
I
S
N
W
K
-----------------------------------------------------------
N
D
L
K
T
P
S
Q
A
------
A
A
--------
S
A
---------------
I
------
G
E
R
D
----
R
I
F
A
H
C
Y
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
--------
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
---
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
-----
A
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
K
R
--------
L
F
--
S
E
--
L
G
Y
G
A
E
-------
L
K
V
L
S
A
N
N
E
E
H
E
A
E
R
V
T
G
E
L
I
A
H
H
F
V
------------
N
K
T
Q
Y
K
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
N
T
P
K
R
E
I
G
P
A
T
L
K
K
L
G
E
W
A
M
T
R
N
K
S
M
F
T
A
S
F
D
-
M
G
-
L
S
Q
-
T
L
S
G
R
G
Y
E
A
L
T
R
F
T
H
W
L
A
E
I
Q
R
L
----
A
E
R
E
P
I
A
A
V
R
D
L
I
H
G
M
D
Y
E
S
W
L
Y
E
T
S
PS
P
K
A
A
E
M
R
M
K
N
V
N
Q
L
F
S
W
M
T
E
M
L
E
G
S
E
-------
L
D
E
P
M
T
L
T
Q
V
V
T
R
F
T
L
R
D
M
M
E
R-----------
E
-
E
E
L
D
Q
-------
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
E
E
G
F
L
P
H
Q
S
S
I
-----------------------------------
D
---
E
D
N
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
C
K
E
R
R
Q
Y
G
E
L
V
R
P
E
P
S
R
F
L
L
E
L
P
Q
D
D
L
I
W
----------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.17
40%
16
- C2 -
-
1UAA
1
REP_ECOLI
A:
[3-636]
-------------
L
N
P
G
Q
Q
Q
A
V
E
F
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
C
--
G
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
L
G
R
-
K
E---------------
A
R
G
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
A
N
F
S
L
F
D
D
T
D
Q
L
A
L
L
K
E
L
T
E
G
L
-
I
E
-----------------------------------------
D
D
K
V
L
L
Q
Q
L
I
-------------------------
S
T
I
S
N
W
K
-----------------------------------------------------------
N
D
L
K
T
P
S
Q
A
------
A
A
--------
S
A
---------------
I
------
G
E
R
D
----
R
I
F
A
H
C
Y
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
--------
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
---
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
-----
A
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
K
R
--------
L
F
--
S
E
--
L
G
Y
G
A
E
-------
L
K
V
L
S
A
N
N
E
E
H
E
A
E
R
V
T
G
E
L
I
A
H
H
F
V
------------
N
K
T
Q
Y
K
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
N
T
P
K
R
E
I
G
P
A
T
L
K
K
L
G
E
W
A
M
T
R
N
K
S
M
F
T
A
S
F
D
-
M
G
-
L
-
S
Q
T
L
S
G
R
G
Y
E
A
L
T
R
F
T
H
W
L
A
E
I
Q
R
L
A
ERE
P
I
A
A
V
R
D
L
I
H
G
-
M
D
Y
E
S
W
L
Y
E
T
S
-
P
S
--
P
K
A
A
E
M
R
M
K
N
------
V
N
Q
L
F
S
W
M
T
E
M
L
E
G
S
E
L
D
E
P
-
M
T
L
T
Q
V
V
T
R
F
T
L
R
D
M
M
E
-------
R
----
E
-
E
E
L
D
Q
-------
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
E
E
G
F
L
P
-
H
Q
S
S
-----------------------------------
I
-
D
-
E
D
N
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
C
K
E
R
R
Q
Y
G
E
L
V
R
P
E
P
S
R
F
L
L
E
L
P
Q
D
--------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
74.08
40%
12
- C2 -
-
1UAA
1
REP_ECOLI
B:
[3-636]
-------------
L
N
P
G
Q
Q
Q
A
V
E
F
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
C
--
G
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
L
G
R
-
K
E---------------
A
R
G
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
A
N
F
S
L
F
D
D
T
D
Q
L
A
L
L
K
E
L
T
E
G
L
-
I
E
-----------------------------------------
D
D
K
V
L
L
Q
Q
L
I
-------------------------
S
T
I
S
N
W
K
-----------------------------------------------------------
N
D
L
K
T
P
S
Q
A
------
A
A
--------
S
A
---------------
I
------
G
E
R
D
----
R
I
F
A
H
C
Y
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
--------
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
---
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
-----
A
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
K
R
--------
L
F
--
S
E
--
L
G
Y
G
A
E
-------
L
K
V
L
S
A
N
N
E
E
H
E
A
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R
V
T
G
E
L
I
A
H
H
F
V
------------
N
K
T
Q
Y
K
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
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L
M
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L
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D
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P
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K
L
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G
R
G
Y
E
A
L
T
R
F
T
H
W
L
A
E
I
Q
R
L
A
ERE
P
I
A
A
V
R
D
L
I
H
G
-
M
D
Y
E
S
W
L
Y
E
T
S
-
P
S
--
P
K
A
A
E
M
R
M
K
N
------
V
N
Q
L
F
S
W
M
T
E
M
L
E
G
S
E
L
D
E
P
-
M
T
L
T
Q
V
V
T
R
F
T
L
R
D
-----------------
E
E
L
D
Q
-------
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
E
E
G
F
L
P
-
H
Q
S
S
-----------------------------------
I
-
D
-
E
D
N
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
C
K
E
R
R
Q
Y
G
E
L
V
R
P
E
P
S
R
F
L
L
E
L
P
Q
D
--------------------------------------------------------------------------------------------------
36
HHSearch
69.26
26%
0
- C- -
-
4CEJ
1
ADDA_BACSU
A:
[10-935]
------------
T
W
T
D
D
Q
W
N
A
I
V
S
T
G
Q
D
I
L
V
A
A
A
A
G
S
G
K
T
A
V
L
V
E
R
M
I
R
K
I
T
A
E
E
N
P
I
D
V
D
R
L
L
V
V
T
F
T
N
A
S
A
A
E
M
K
H
R
I
A
E
A
L
E
K
-
E
L
V
Q
R
PGS
L
H
I
R
R
Q
L
S
L
L
N
R
A
S
I
S
T
L
H
S
F
C
L
Q
V
L
K
K
Y
Y
Y
L
I
D
L
D
P
G
F
R
I
A
D
Q
T
E
G
E
L
I
G
D
E
V
L
D
E
L
F
E
D
E
Y
A
K
GE
K
A
F
F
E
L
V
D
R
YTTDRHD
L
D
L
Q
F
L
V
K
Q
V
Y
E
Y
S
R
S
HPN
P
E
A
W
-
L
E
S
F
V
HLYDVSEKSAIEELPFY
Q
Y
V
K
E
D
I
A
M
V
L
N
G
A
K
E
K
L
L
R
A
L
E
L
T
K
APGGPAPR
A
D
N
F
L
D
D
L
A
Q
I
D
E
L
I
Q
H
Q
DD
F
S
E
L
Y
K
R
V
PA
V
S
F
K
R
AK
A
V
K
G
D
E
F
D
P
A
L
L
D
E
A
T
D
L
R
N
G
A
K
K
L
L
E
K
L
K
T
D
YFTRS
P
E
Q
H
L
K
S
L
A
E
M
K
P
V
I
E
T
L
V
----
Q
L
V
I
S
Y
G
K
R
F
E
A
A
K
Q
E
K
S
I
I
D
F
S
D
L
E
H
Y
C
L
A
I
L
T
A
E
NDKG
E
R
E
P
S
E
A
A
R
F
Y
Q
E
Q
F
H
E
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S
G
PEE
T
G
N
L
F
M
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
T
ESGEG
T
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
L
M
G
G
K
I
G
E
VDYDEQAE
L
K
LG
A
A
Y
P
D
N
D
E
T
E
T
E
L
L
L
I
D----
E
L
E
T
V
Q
F
E
A
K
A
I
A
K
E
I
R
K
L
I
S
S
P
F
K
V
Y
DGKKK
T
H
R
N
I
Q
Y
R
D
I
V
I
L
L
R
S
M
P
W
A
P
Q
I
M
E
E
L
R
A
Q
G
I
P
V
Y
A
N
L
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
A
S
V
L
R
S
P
I
V
G
A
D
E
N
E
L
S
L
I
R
L
E
N
--
K
K
A
P
Y
Y
E
A
M
K
D
-
Y
L
A
A
-
G
-
D
R
S
D
E
L
Y
Q
K
L
N
T
F
Y
G
H
L
Q
K
W
R
A
F
S
---
K
N
H
S
V
S
E
L
I
W
E
V
Y
R
D
T
K
Y
M
D
Y
V
G
G
M
----
P
G
G
K
Q
R
Q
A
N
L
R
V
L
Y
D
R
A
R
Q
Y
E
S
T
-----------
A
F
R
G
L
F
R
F
L
R
F
I
E
R
M
Q
E
R
G
D
D
L
G
---
T
A
RG
L
S
-
E
Q
E
D
V
-------
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
G
L
G
R
N
-
F
N
M
M
D
L
N
KS
Y
L
L
D
KEL
G
F
G
T
K
YIHPQLR
I
S
Y
P
T
L
P
L
I
A
M
K
K
K
M
-
R
-
R
E
L
L
S
E
E
L
R
V
L
Y
V
A
L
T
R
A
K
E
K
L
F
L
I
G
S
C
K
D
H
Q
-
K
Q
L
A
K
W
Q
A
S
A
S
Q
T
-------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
43.01
69%
-102
- C2 -
-
2PJR
1
?
G:
[4-92]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
-----------------------------------
E
-
D
-
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
-----------------------------------------------------------------------------------------------
32
PsiBlast_CBE
40.68
69%
-104
- C2 -
-
2PJR
1
?
B:
[4-92]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
-----------------------------------
E
-
D
-
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
-----------------------------------------------------------------------------------------------