@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U2N0: (2017-12-23 )
MANDKITIHGARAHNLKNIDVTIPRDKFVVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLGQMDKPDVDSIDGLSPAISIDQKTTSKNPRSTVGTVTEINDYLRLLFARVGHPICPNDHIEITSQSVDQMADQVMALPERTKIQVLAPIVVKKKGQHKKIFERIQKEGYVRVRVDGEIYDLSEVPELEKNKKHDIAIVIDRIIVKEGIRSRLFDSLEAALRLADGYALVDVIGEEEMLFSEHYACPYCGFTVGELEPRLFSFNAPFGACPDCDGLGVKLEVDQDLVIPDRTKTLSQGAIVPWNPISSQYYPQMLAQACESFGIDLDTPFEELPEEHQEIILNGTDDLFHFHYENDFGGVRDVETTFEGVLKNIERRYHDTNSDFTREQMRLYMTELTCQTCKGYRLNPQALSVQINGTNIGQTNELSIQKAVDFFSNLTLSEQEKVIAKPILKEVNDRLSFLENVGLDYLTLSRASGTLSGGEAQRIRLATQIGSNLSGVLYILDEPSIGLHQRDNDRLIGSLKKMRDLGNTLVVVEHDEDTMWAADYLIDVGPGAGEQGGQIVAAGTPEEVANDENSLTGKYLSGKKSIPVPKERRKGNGKAIKITGASENNLKNISVEFPLGEFVAVTGVSGSGKSTLVNSILKKSLAQKLNKNSAKPGKFKTISGYESIEKIIDIDQSPIGRTPRSNPATYTSVFDDIRGLFAQTNEAKMRGYKKGRFSFNVKGGRCEACRGDGIIKIEMHFLPDVYVPCEVCHGKRYNSETLEVHYKGKSIADILEMTVEDAVEFFKHIPKIHRKLQTIVDVGLGYVTMGQPATTLSGGEAQRMKLASELHKISNGKNFYILDEPTTGLHSDDIARLLHVLQRLVDAGNTVLVIEHNLDVIKTADYIIDLGPEGGEGGGTILATGTPEEIINVKESYTGHYLKKIMV
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250...-....260.......270.......280.......290.......300.......-310.......320.......330.......340.......350-...--....------360....-...370.......----380.----......390.......400.......410.......420..--------.....430.---......440.---......450--......------.--------..460.......470.......480.......490.......500.--......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......-610.......620.......630.......640.......650.....----..660....--------..-.670--.......-------.680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800--------------.......810.......820.......830.......840.......---850.......860.......870......-.880......----.890.......900.......910.......920---...-....930......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAND
K
I
T
I
HGARAHNL
K
N
I
D
V
T
IPRD
K
F
V
V
V
TGLSGSGKS
S
L
A
F
D
T
L
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
GQMDKPDVDSIDGLSP
A
I
S
IDQKTTSKNPRSTVG
T
V
T
E
I
N
D
Y
L
R
L
L
F
A
RVGHPICPND
H
I
E
I
T
S
Q
S
V
D
Q
M
A
D
Q
V
MALPER
T
K
I
Q
V
L
A
P
I
V
VKKKG
Q
H
K
K
I
F
E
R
I
Q
KEG
Y
V
R
V
R
VD
G
E
IY
D
L
S
EVPELEKNKKH
D
I
A
I
V
I
D
R
I
I
V
K
E
G
I
R
S
R
L
F
D
S
L
E
A
A
L
R
LAD
G
Y
A
L
V
D
VIGE
E
E
M
L
F
SEHYACPYC-GFTVGELE
P
R
L
F
SFNAPFGACPDCDGL
G
V
K
L
EVDQDLVIPDRTKTLSQG
A
I
VPW-NPIS
S
Q
Y
Y
P
Q
M
L
A
Q
A
C
E
SFGIDLDT
P
F
E
EL
P
E
E
H
Q
E
I
ILNGTD-
D
L
F
--
H
F
H
Y------ENDFGGV-
R
D
V
E
T
T
F
E
G
V
L
K
N
----
I
E
R
R
----YHDTNSD
F
T
R
E
Q
M
R
L
Y
M
T
E
L
T
C
Q
TCKGYRL
N
P
Q
A
L
S
V
Q
ING--------TNIGQT
N
E
L
---
S
I
Q
K
A
V
D
F
F
S---NLT
L
S
E
Q
----
E
K
V
I
A
K
------
P
--------
I
L
K
E
V
N
D
R
L
S
F
L
E
NVGL
D
Y
L
T
LSRASGTLSGGE
A
Q
R
I
R
L
A
TQIGSN--L
S
G
V
L
Y
I
LDEPSIGLHQRD
N
D
R
L
I
G
S
L
K
K
M
R
DLG
N
T
L
V
V
V
EHDED
T
M
W
A
A
D
Y
L
I
DVGPGAGEQG
G
Q
I
V
AAG
T
P
E
E
VANDENSLTGKYLSGKKSIPV
P
K
E
RRKGNG
K
-
A
I
K
I
TGASENNL
K
N
I
S
V
E
FPLG
E
F
V
A
V
TGVSGS
G
K
S
T
L
V
N
S
I
L
K
K
S
L
A
----
Q
K
L
NKNSAK--------PG-
K
F
K
---TIS
G
Y
E
S
-------
I
E
K
I
I
DIDQSPIGRTPRSNP
A
T
Y
T
S
V
F
D
D
I
R
G
L
FAQT
N
E
A
K
MRGYKKG
R
F
S
F
NVKG
G
R
C
E
ACRGD
G
I
I
K
I
E
M
H
FLPDVYV
P
C
E
VCHGKRYNS
E
T
L
E
V
H
YKG
K
S
I
A
D
I
L
E
M
T
V
E
D
A
V
E
F
F
K
H
I
P
K
--------------
I
H
R
K
L
Q
T
I
V
D
VGL
G
Y
V
TMGQPATTLSGG
E
A
Q
R
M
K
L
A
S
E
L
H
K
ISNG
K
N
---
F
Y
I
LDEPTTGL
H
S
D
D
I
A
R
L
L
H
V
L
Q
R
L
V
DA-G
N
T
V
L
V
I
EHN----L
D
V
I
K
TA
D
Y
I
I
D
LGPEGGEGG
G
T
I
L
ATG
T
P
E
E
I
I
---
N
V
K
-
E
S
Y
T
G
H
Y
L
K
K
IMV
1
PsiBlast_PDB
79.51
71%
-14
- C8 -
-
3UWX
-
?
A:
[22-956]
---
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
I
V
S
G
K
K
G
T
H
A
K
T
L
E
D
I
R
K
Q
G
Y
V
R
V
R
I
D
R
E
M
R
E
L
T
G
D
I
E
L
E
K
N
K
K
H
S
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
-
E
P
----
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
I
--
Y
F
R
Y
------
T
N
D
F
G
Q
V
-
R
E
Q
Y
I
A
F
E
G
V
I
P
N
----
V
E
R
R
----
Y
R
E
T
S
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
---
S
V
T
E
A
L
A
F
F
D
---
G
L
E
L
T
E
K
----
E
A
Q
I
A
R
------
L
--------
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
--
L
T
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
F
I
P
I
P
A
E
R
R
R
P
D
G
R
-
W
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
----
Q
K
L
H
R
A
K
A
K
--------
P
G
-
E
H
R
---
D
I
R
G
L
E
H
-------
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
M
H
F
L
P
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
P
K
--------------
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
---
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
-
G
D
T
V
L
V
I
E
H
N
----
L
D
V
I
K
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
---
E
V
K
-
E
S
H
T
G
R
Y
L
K
P
I
L
-
2
PsiBlast_PDB
75.11
70%
-9
- C4 -
-
2R6F
2
?
A:
[22-956]
---
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
-
E
P
----
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
I
--
Y
F
R
Y
------
T
N
D
F
G
Q
V
-
R
E
Q
Y
I
A
F
E
G
V
I
P
N
----
V
E
R
R
----
Y
R
E
T
S
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
---
S
V
T
E
A
L
A
F
F
D
---
G
L
E
L
T
E
K
----
E
A
Q
I
A
R
------
L
--------
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
--
L
T
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
F
I
P
I
P
A
E
R
R
R
P
D
G
R
-
W
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
----
Q
K
L
H
R
A
K
A
K
--------
P
G
-
E
H
R
---
D
I
R
G
L
E
H
-------
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
M
H
F
L
P
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
P
K
--------------
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
---
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
-
G
D
T
V
L
V
I
E
H
N
----
L
D
V
I
K
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
---
E
V
K
-
E
S
H
T
G
R
Y
L
K
P
I
L
-
3
PsiBlast_PDB
71.50
57%
-1
- C4 -
-
3ZQJ
-
UVRA_MYCTU
A:
[24-974]
---
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
R
L
T
V
K
A
A
A
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
D
--
E
Q
R
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
D
P
D
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T
L
A
Q
G
A
V
A
P
W
S
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
G
A
D
-
E
Q
V
--
H
V
R
Y
------
R
N
R
Y
G
R
T
-
R
S
Y
Y
A
D
F
E
G
V
L
A
F
----
L
Q
R
K
----
M
S
Q
T
E
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
E
SKGEH
G
A
K
S
I
A
E
V
C
E
L
---
S
I
A
D
C
A
D
F
L
N
---
A
L
T
L
G
P
R
----
E
Q
A
I
A
G
------
Q
--------
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
--
L
V
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
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T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
E
S
I
E
I
P
A
I
R
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
E
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
----
N
R
L
N
G
A
R
Q
V
--------
P
G
-
R
H
T
---
R
V
T
G
L
D
Y
-------
L
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
M
N
F
L
P
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
A
G
--------------
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
---
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
K
-
G
N
T
V
I
V
I
E
H
N
----
L
D
V
I
K
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
---
A
V
P
-
A
S
Y
T
G
K
F
L
A
E
V
V
-
4
PsiBlast_PDB
50.79
42%
25
- C4 -
-
2VF7
2
?
A:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
-
Q
P
V
--
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
-
K
K
M
E
P
S
Y
M
G
T
F
S
S
----
A
R
R
H
V
L
H
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
---
P
L
A
R
V
S
E
L
L
R
---
P
Y
A
E
E
R
E
PGHA
E
R
V
K
N
R
------
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
--
L
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
H
T
E
-
P
H
T
P
R
E
P
A
G
W
--
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
-----------------
G
-
S
A
R
---
L
G
G
D
L
A
Q
-------
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
L
L
F
L
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
A
--------------
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
---
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
-
G
N
T
V
I
A
V
E
H
K
----
M
Q
V
V
A
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
---
Q
A
A
-
G
S
V
T
A
P
Y
L
R
A
A
L
-
26
PsiBlast_CBE
49.74
42%
26
- C4 -
-
2VF7
2
?
B:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
-
Q
P
V
--
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
-
K
K
M
E
P
S
Y
M
G
T
F
S
S
----
A
R
R
H
V
L
H
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
---
P
L
A
R
V
S
E
L
L
R
---
P
Y
A
E
E
R
E
PG
H
A
E
R
V
K
N
R
------
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
--
L
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
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H
D
L
D
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I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
H
T
E
-
P
H
T
P
R
E
P
A
G
W
--
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
-----------------
G
-
S
A
R
---
L
G
G
D
L
A
Q
-------
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
-----
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
A
--------------
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
---
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
-
G
N
T
V
I
A
V
E
H
K
----
M
Q
V
V
A
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
---
Q
A
A
-
G
S
V
T
A
P
Y
L
R
A
A
L
-
24
PsiBlast_CBE
49.67
42%
29
- C4 -
-
2VF8
2
?
B:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
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G
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A
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----
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Q
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L
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K
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----
A
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A
S
M
K
K
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--------
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---
P
L
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---
P
Y
A
E
E
R
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PG
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------
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A
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M
A
A
D
L
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R
L
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L
L
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L
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L
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L
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--
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--
L
E
L
N
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N
L
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L
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R
F
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L
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M
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A
L
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DPADHT
A
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-
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---
L
G
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-------
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K
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I
A
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A
H
D
F
F
A
D
E
S
A
--------------
I
F
R
A
L
D
T
L
R
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V
G
L
G
Y
L
R
L
G
Q
P
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G
G
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Q
R
I
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L
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R
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R
G
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---
V
Y
V
L
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G
L
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A
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----
M
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A
A
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---
Q
A
A
-
G
S
V
T
A
P
Y
L
R
A
A
L
-
25
PsiBlast_CBE
49.64
42%
23
- C4 -
-
2VF7
2
?
C:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
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L
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R
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----
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--
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GLT
P
A
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A
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P
S
Y
M
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T
F
S
S
----
A
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A
N
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A
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M
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P
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R
L
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A
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--------
L
D
I
T
E
L
S
R
L
---
P
L
A
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V
S
E
L
L
R
---
P
Y
A
E
E
R
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PGHA
E
R
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K
N
R
------
P
EQ
A
I
A
L
Q
R
M
A
A
D
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A
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A
L
A
A
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S
A
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---
L
G
G
D
L
A
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-------
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A
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A
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D
F
F
A
D
E
S
A
--------------
I
F
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A
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D
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L
R
E
V
G
L
G
Y
L
R
L
G
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G
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---
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L
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A
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A
---
Q
A
A
-
G
S
V
T
A
P
Y
L
R
A
A
L
-
129
HHSearch
48.57
44%
19
* C4 *
-
2VF7
2
?
C:
[141-841]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
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P
D
P
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---
G
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P
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---
A
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K
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--------
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L
L
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Y
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----
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N
R
P
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A
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A
L
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--------
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A
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L
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--
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A
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--------------------------
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DLAQ
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L
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L
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F
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L
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L
A
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D
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A
H
D
F
F
A
D
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S
A
--------------
I
F
R
A
L
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T
L
R
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V
G
L
G
Y
L
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L
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---
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A
---
Q
A
A
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A
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L
R
A
A
L
-
128
HHSearch
48.45
44%
35
- C4 -
-
2VF8
2
?
B:
[141-841]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
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Q
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---
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LT
P
---
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K
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M
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--------
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L
L
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----
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A
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A
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--------
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--
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D-------
P
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DLAQ
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F
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A
--------------
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
---
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
-
G
N
T
V
I
A
V
E
H
K
----
M
Q
V
V
A
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
---
Q
A
A
-
G
S
V
T
A
P
Y
L
R
A
A
L
-
5
PsiBlast_PDB
48.29
42%
33
- C4 -
-
2VF8
2
?
A:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
-
Q
P
V
--
V
P
V
Y
PGLT
P
A
E
T
Q
R
A
L
K
-
K
K
M
E
P
S
Y
M
G
T
F
S
S
----
A
R
R
H
V
L
H
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
---
P
L
A
R
V
S
E
L
L
R
---
P
Y
A
E
E
R
E
PGHA
E
R
V
K
N
R
------
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
--
L
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
---
E
-
P
H
T
P
R
E
P
A
G
W
--
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
-----------------
G
-
S
A
R
---
L
G
G
D
L
A
Q
-------
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
-----
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
A
--------------
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
---
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
-
G
N
T
V
I
A
V
E
H
K
----
M
Q
V
V
A
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
---
Q
A
A
-
G
S
V
T
A
P
Y
L
R
A
A
L
-
17
PsiBlast_PDB
39.90
38%
-150
- C5 -
-
5LW7
-
?
B:
[215-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
------
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
-
G
K
A
V
L
V
V
E
H
D
----
L
A
V
L
---
D
Y
L
S
D
V
-----------------------------------------
16
PsiBlast_PDB
39.83
38%
-150
- C5 -
-
3J15
-
?
B:
[215-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
------
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
-
G
K
A
V
L
V
V
E
H
D
----
L
A
V
L
---
D
Y
L
S
D
V
-----------------------------------------
36
PsiBlast_CBE
38.28
32%
-90
- C5 -
-
4P33
3
LPTB_ECOLI
A:
[132-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
G
Q
---
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
---
A
A
N
P
K
---
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
D
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
-
Y
I
V
S
--------
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
Q
D
E
H
V
K
-
R
V
Y
L
G
--------
58
PsiBlast_CBE
37.88
32%
-123
- C5 -
-
3TIF
2
Y796_METJA
B:
[146-218]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
---
A
N
N
P
P
---
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
----
I
N
V
A
R
F
G
E
R
I
I
Y
L
-----------------------------------------
69
PsiBlast_CBE
37.56
32%
-120
- C5 -
-
1L2T
3
Y796_METJA
B:
[146-218]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
---
A
N
N
P
P
---
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
----
I
N
V
A
R
F
G
E
R
I
I
Y
L
-----------------------------------------
15
PsiBlast_PDB
37.19
38%
-141
- C5 -
-
3BK7
-
?
A:
[229-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
------
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
-
G
K
A
V
L
V
V
E
H
D
----
L
A
V
L
---
D
Y
L
S
D
V
-----------------------------------------
35
PsiBlast_CBE
37.13
32%
-81
- C5 -
-
4P33
2
LPTB_ECOLI
B:
[132-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
G
Q
---
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
---
A
A
N
P
K
---
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
D
S
-
G
L
G
V
L
I
T
D
H
N
VRET
L
A
V
C
E
R
A
-
Y
I
V
S
--------
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
QDE
H
V
K
-
R
V
Y
L
G
--------
70
PsiBlast_CBE
37.03
32%
-116
- C5 -
-
1L2T
3
Y796_METJA
A:
[146-218]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
---
A
N
N
P
P
---
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
----
I
N
V
A
R
F
G
E
R
I
I
Y
L
-----------------------------------------
120
PsiBlast_CBE
36.70
45%
-259
- C7 -
-
3TUZ
1
METN_ECOLI
G:
[44-74]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
36.66
33%
-114
- C5 -
-
4AYW
-
ABCBA_HUMAN
A:
[490-585]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
N
A
V
A
F
I
R
N
F
P
Q
-----------------
G
F
N
T
V
V
---------
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
---
N
P
K
---
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
R
T
V
L
V
I
A
H
H
----
L
S
T
I
K
N
A
N
M
V
A
V
L
-----------------------------------------
134
HHSearch
34.58
45%
-8
- C4 -
-
3PIH
2
UVRA_THEMA
A:
[383-571]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
C
S
V
C
G
G
R
R
L
N
R
E
A
L
S
V
K
I
N
G
L
N
I
H
E
F
T
E
L
S
I
S
E
E
L
E
F
L
K
N
L
N
L
T
E
R
E
R
E
I
V
G
E
L
L
K
E
I
E
K
R
L
E
F
L
V
D
V
G
L
E
Y
L
T
L
S
R
S
A
T
T
L
S
G
G
E
S
Q
R
I
R
L
A
T
Q
I
G
S
G
-
L
T
G
V
---
I
Y
V
L
D
E
P
T
I
G
L
H
P
R
D
T
E
R
L
I
K
T
L
K
K
L
R
D
L
-
G
N
T
V
I
V
V
E
H
D
----
E
E
V
I
R
N
A
D
H
I
I
D
I
G
P
G
G
G
T
N
G
G
R
V
V
F
Q
G
T
V
D
E
L
L
---
K
N
P
D
S
S
L
T
G
E
Y
L
-----