@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U2N7: (2017-12-23 )
MSKIIGIDLGTTNSAVAVLEGNEAKIIANPEGNRTTPSVVSFKNGEIQVGEVAKRQAVTNPNTISSIKRHIGEAGYKVDVEGKSYTPQEISAMILQYIKGFAEDYLGEKVEKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDRDEKILVFDLGGGTFDVSILELGDGVFDVLSTAGDNHLGGDDFDNKIIDYMVAEFKKENSIDLSQDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGESGPLHLEMTLTRAKFDELTADLVERTKVPVRQALKDAGLSQSEIDEVILVGGSTRIPAVVEAVRKETGKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDKNGIVNVSAKDLGTQKEQKITIKSSSGLTDEEIERMVKDAEANAEADKARKEEVDLRNDVDALLFSVDKTLKELEGKVDEEEVKKAETARDELKAAVEANNIEEMKTKRDALNEIVQNLTVKLYEQAAQQQAQENPEAAQGGADDVVDADFEEVDGDDK
Atome Classification :
(92 SA)
...--......10........20........30........40.-.-.-.....50........60-........70.----------------------------.-----------------------..------------------------.-------------.-------------.------------------------.-----------80--.----.-------------....--...90........100.......110.......120.......130.......140.......150....--...---160..-.....170.......180----..----.....190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320....-.-.-.-330........340.......350...-----.-----...360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470....-.-..480.......490.......500.......510.......520--..---......530.......540....--...550-.........560.......570.......580.......590.......600.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
K
--
I
I
G
I
D
LGTTN
S
A
V
A
V
L
EGN
E
A
K
I
I
ANPEGNRTT
P
S
V
V
S
F-K-N-G
E
I
Q
V
G
E
V
A
K
R
QAVTNP-
N
T
I
S
S
I
K
R
H
IG----------------------------E-----------------------AG------------------------
Y
-------------
K
-------------
V
------------------------
D
-----------V---E----G-------------KSY
T
--
P
Q
E
I
S
A
M
I
L
Q
Y
I
K
G
F
A
E
D
Y
L
G
E
K
V
E
K
A
V
I
T
VPAYF
N
D
A
Q
R
Q
A
T
KDAGKIAGL
E
V
E
R
I
VNEP
T
A
A
A
L
A
YGL--DKT---DRD
E
K
-
I
L
V
F
DLGG
G
T
F
D
V
S
I
L
EL----G
D
----
G
V
F
D
V
L
S
TAGDNHLGGDDF
D
N
K
I
I
D
Y
M
V
A
E
F
KKENSIDL
S
Q
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
D
LSGVSST
Q
I
S
L
P
F
I
TAGESG
P
L
H
L
E
M
T
L
T
R
A
K
F
D
E
L
T
A
D
L
V
E
RTK
V
P
V
R
Q
A
L
K
DAGL
S
Q
S
E
I
D
E
V
I
L
VGGSTR
I
P
A
V
V
E
A
V
R
K
-E-T-G-K-EPNKSV
N
P
D
E
V
V
A
MGAAIQG
G
V
I
TG-----D-----V
K
D
V
V
L
L
DVT
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
IDRNTTIPTSK
S
Q
V
F
STAADNQP
A
V
D
I
H
V
LQGERPMAADNKTLG
R
F
Q
LTDIPAAPRGI
P
Q
I
E
V
T
F
DIDKN
G
I
V
N
V
S
A
K
DLGTQK
E
Q
K
I
T
I
KSSS-G-L
T
D
E
E
I
E
R
M
V
K
D
AEANAEA
D
K
A
R
K
E
EVDLR
N
D
V
D
A
L
L
F
S
V
D
K
T
L
---
K
E
---
L
EGKV
D
E
E
E
V
K
K
A
E
T
A
R
D
E
L
K
A
A
--
V
EAN---
N
I
E
E
M
K
T
K
R
D
A
L
N
E
I
V
Q
N
L
T
V
K
L
Y
E
Q
A
A
Q
Q
Q
A
QENPEAAQGGADDVVDA
D
F
E
EVDGDDK
1
PsiBlast_PDB
90.60
81%
-65
- C2 -
-
2V7Y
1
DNAK_GEOKA
A:
[1-504]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
-
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
----------------------------------------------------
T
D
------------------------
Y
-------------
K
-------------
V
------------------------
E
-----------
I
---
E
----
G
-------------
K
Q
Y
T
--
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
----
E
E
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
-
E
-
L
-
G
-
K
-
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
-----
E
-----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
S
-
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
------------------------------------------------------------------------------------------------------------------
118
HHSearch
90.38
81%
-65
- C2 -
-
2V7Y
1
DNAK_GEOKA
A:
[1-504]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
-
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
----------------------------
T
-----------------------
D
Y
--------------------------------------
K
-------------
V
------------------------
E
-----------
I
---
E
----
G
-------------
K
Q
Y
T
--
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
E
----
E
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
-
E
-
L
-
G
-
K
-
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
-----
E
-----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
S
-
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
------------------------------------------------------------------------------------------------------------------
117
HHSearch
75.67
81%
-
- C2 -
-
4ANI
-
DNAK_GEOKA
C:
[1-509]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
-
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
----------------------------
T
-----------------------
D
Y
--------------------------------------
K
-------------
V
------------------------
E
-----------
I
---
E
----
G
-------------
K
Q
Y
T
--
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
E
----
E
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
-
E
-
L
-
G
-
K
-
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
-----
E
-----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
S
-
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
R
N
E
A
D
-------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.67
81%
-
- C2 -
-
4ANI
-
DNAK_GEOKA
C:
[1-509]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
-
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
----------------------------------------------------
T
D
------------------------
Y
-------------
K
-------------
V
------------------------
E
-----------
I
---
E
----
G
-------------
K
Q
Y
T
--
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
----
E
E
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
-
E
-
L
-
G
-
K
-
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
-----
E
-----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
S
-
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
R
N
E
A
D
-------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
74.49
56%
43
- C2 -
-
4JN4
4
DNAK_ECOLI
B:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
-
D
-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
----------------------------
R
RFQDEEVQRDVSIMPFKIIAADN
G
D
------------------------
A
-------------
W
-------------
V
------------------------
E
-----------
V
---
K
----
G
-------------
Q
K
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
-
F
-
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
---
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
--
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
----------------------------------------
21
PsiBlast_CBE
74.30
56%
42
- C2 -
-
4JNE
4
DNAK_ECOLI
B:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
-
D
-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
----------------------------
R
RFQDEEVQRDVSIMPFKIIAADN
G
D
------------------------
A
-------------
W
-------------
V
------------------------
E
-----------
V
---
K
----
G
-------------
Q
K
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
-
F
-
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
---
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
--
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
----------------------------------------
109
HHSearch
74.21
59%
43
- C2 -
-
4JNE
4
DNAK_ECOLI
A:
[1-600]
S
G
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
-
T
-
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
----------------------------
R
-----------------------
R
F
------------------------
Q
-------------
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
--------------
E
-----------
V
---
K
----
G
-------------
Q
K
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
----
D
E
V
DG
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
-
F
-
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
----
G
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
---
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
--
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
Q
----------------------------------
108
HHSearch
74.12
59%
44
- C2 -
-
4B9Q
1
DNAK_ECOLI
A:
[2-602]
-
G
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
-
T
-
Q
D
G
C
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
----------------------------
R
-----------------------
R
F
------------------------
Q
-------------
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
--------------
E
-----------
V
---
K
----
G
-------------
Q
K
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
----
D
E
V
DG
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
-
F
-
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
C
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
---
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
--
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
------------------------------------
6
PsiBlast_PDB
73.69
56%
43
- C2 -
-
4B9Q
1
DNAK_ECOLI
A:
[3-602]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
-
D
-
G
C
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
----------------------------
R
RFQD
E
E
V
Q
R
D
V
S
I
----------
M
P
------------------------
F
-------------
K
I
I
A
A
DNG
D
A
W
---
V
------------------------
E
-----------
V
---
K
----
G
-------------
Q
K
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
-
F
-
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
C
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
---
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
--
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
----
K
L
M
E
I
A
--------------------------------
4
PsiBlast_PDB
73.46
56%
42
- C2 -
-
4JN4
4
DNAK_ECOLI
A:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
-
D
-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
----------------------------
R
RFQD
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DN
G
D
------------------------
A
-------------
W
-------------
V
------------------------
E
-----------
V
---
K
----
G
-------------
Q
K
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
-
F
-
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
---
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
--
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
----------------------------------------
5
PsiBlast_PDB
73.25
56%
43
- C2 -
-
4JNE
4
DNAK_ECOLI
A:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
-
D
-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
----------------------------
R
RFQD
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DN
G
D
------------------------
A
-------------
W
-------------
V
------------------------
E
-----------
V
---
K
----
G
-------------
Q
K
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
-
F
-
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
---
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
--
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
----------------------------------------
112
HHSearch
70.93
53%
49
- C2 -
-
5E84
1
GRP78_HUMAN
B:
[5-606]
-
G
T
--
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
-
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
----------------------------
R
-----------------------
T
W
------------------------
N
DPSVQQDIKFLPF
K
-------------
V
VEKKTKPYIQV-------------
D
-----------
I
GGG
Q
----
T
-------------
K
T
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
R
---
E
G
E
K
N
-
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
----
E
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
-
F
-
F
-
N
G
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
-----
D
QD---
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
----
G
G
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
N
R
-
L
T
P
E
E
I
E
R
M
V
N
D
A
E
K
F
A
E
E
D
K
K
L
K
E
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
---
G
D
KEK
L
G
G
K
L
S
S
E
D
K
E
T
M
E
K
A
V
E
E
K
I
E
W
--
L
E
S
H
QDA
D
I
E
D
F
K
A
K
K
K
E
L
E
E
I
V
Q
P
I
I
S
K
-------------------------------------
3
PsiBlast_PDB
70.76
56%
45
- C3 -
-
2KHO
-
DNAK_ECOLI
A:
[4-603]
-----
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
-
D
-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
----------------------------
R
RFQD
E
E
V
Q
R
D
V
S
IMP
F
K
I
I
A
A
DN
G
D
------------------------
A
-------------
W
-------------
V
------------------------
E
-----------
V
---
K
----
G
-------------
Q
K
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D
EVD
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
-
F
-
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
D
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
---
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
--
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
----
K
L
M
E
I
A
Q
-------------------------------
27
PsiBlast_CBE
69.71
49%
48
- C2 -
-
5E84
1
GRP78_HUMAN
B:
[7-606]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
----------------------------
R
-----------------------
T
W
NDPSVQQDIKFLPFKVVEKKTKPY
I
-------------
Q
-------------
V
------------------------
D
-----------
I
---
G
----
G
GQT----------
K
T
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
R
---
E
G
E
K
N
-
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
-
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
DQ---
D
-----
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
G
G
----
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
-
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
K
F
A
E
E
D
K
K
L
K
E
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
GDK
E
K
---
L
G
G
K
L
S
S
E
D
K
E
T
M
E
K
A
V
E
E
K
I
E
W
--
L
E
S
H
QDA
D
I
E
D
F
K
A
K
K
K
E
L
E
E
I
V
Q
P
I
I
S
K
-------------------------------------
26
PsiBlast_CBE
69.01
49%
47
- C2 -
-
5E84
1
GRP78_HUMAN
C:
[7-606]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
----------------------------
R
-----------------------
T
W
NDPSVQQDIKFLPFKVVEKKTKPY
I
-------------
Q
-------------
V
------------------------
D
-----------
I
---
G
----
G
GQT----------
K
T
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
R
---
E
G
E
K
N
-
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
-
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
DQ---
D
-----
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
G
G
----
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
-
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
K
F
A
E
E
D
K
K
L
K
E
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
GDK
E
K
---
L
G
G
K
L
S
S
E
D
K
E
T
M
E
K
A
V
E
E
K
I
E
W
--
L
E
S
H
QDA
D
I
E
D
F
K
A
K
K
K
E
L
E
E
I
V
Q
P
I
I
S
K
-------------------------------------
8
PsiBlast_PDB
68.74
49%
47
- C2 -
-
5E84
1
GRP78_HUMAN
A:
[7-606]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
----------------------------
R
-----------------------
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
-------------
Q
-------------
V
------------------------
D
-----------
I
---
G
----
G
G
Q
T
----------
K
T
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
R
---
E
G
E
K
N
-
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
-
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
DQ---
D
-----
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
G
G
----
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
-
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
K
F
A
E
E
D
K
K
L
K
E
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
G
DK
E
K
---
L
G
G
K
L
S
S
E
D
K
E
T
M
E
K
A
V
E
E
K
I
E
W
--
L
E
S
H
Q
DA
D
I
E
D
F
K
A
K
K
K
E
L
E
E
I
V
Q
P
I
I
S
K
-------------------------------------
110
HHSearch
66.09
46%
38
- C2 -
-
5TKY
2
SSB1_CHATD
A:
[14-619]
-
D
G
--
A
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
G
T
N
V
E
I
I
A
N
E
Q
G
N
F
T
T
P
S
F
V
S
F
-
T
-
E
-
N
C
R
L
I
G
E
A
A
K
N
Q
A
A
M
N
P
A
N
T
I
F
D
V
K
R
L
I
G
----------------------------
R
-----------------------
R
F
------------------------
D
D
P
T
V
K
K
D
M
E
S
WP
F
K
-------------
V
V
D
D
NG
N
P
K
V
E
V
-------------
Q
-----------
Y
LG-
Q
----
T
-------------
H
T
F
S
--
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
T
K
L
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
N
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
G
S
G
KS-
D
K
E
R
N
-
V
L
I
Y
D
L
G
G
G
A
F
D
V
S
L
L
N
I
----
Q
G
----
G
V
F
T
V
K
A
T
A
G
D
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
Y
C
K
K
E
F
T
R
K
T
K
K
D
L
S
G
D
A
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
G
A
Q
T
T
I
E
I
D
S
L
F
D
G
----
E
D
F
N
I
Q
I
T
R
A
R
F
E
D
L
N
A
K
A
F
A
G
T
L
E
P
V
A
Q
V
L
K
D
A
G
I
E
K
H
Q
V
D
E
I
V
L
V
G
G
S
T
R
I
P
R
I
Q
K
L
L
S
E
-
F
-
F
-
D
-
G
K
K
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
I
L
S
G
-----
K
ATSAD--
D
L
L
L
L
D
V
V
P
L
S
L
G
V
A
M
E
G
N
I
F
A
P
V
V
P
R
G
Q
T
V
P
T
I
K
K
R
T
F
T
T
V
A
D
N
Q
Q
T
V
Q
F
P
V
Y
Q
G
E
R
V
N
C
E
D
N
T
L
L
G
E
F
T
L
A
P
I
P
P
M
K
A
G
E
P
V
L
E
V
V
F
E
V
D
V
N
G
I
L
K
V
T
A
T
E
K
T
S
G
R
S
A
N
I
T
I
A
N
S
V
G
K
-
L
S
T
D
E
I
E
K
M
I
S
D
A
E
K
F
K
S
K
C
E
A
F
S
K
R
F
E
A
K
Q
Q
L
E
S
Y
I
S
R
V
E
E
I
I
---
S
D
------------
K
D
K
I
E
Q
A
L
S
E
A
M
A
Q
--
L
E
I
E
DS-
T
A
D
E
L
K
K
K
E
L
A
L
K
R
L
V
T
K
A
M
A
--------------------------------------
115
HHSearch
66.00
54%
44
- C2 -
-
4FL9
3
HSP7C_BOVIN
A:
[4-553]
-
G
P
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
----------------------------
R
-----------------------
R
F
------------------------
D
-------------
D
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
-------------
E
Y
K---------
G
---
E
----
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
V--
G
A
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
A
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
-
F
-
F
-
N
G
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
------------
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
-
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
---------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
65.40
45%
33
- C2 -
-
5TKY
2
SSB1_CHATD
B:
[17-614]
------
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
G
T
N
V
E
I
I
A
N
E
Q
G
N
F
T
T
P
S
F
V
S
F
-
T
-
E
-
N
C
R
L
I
G
E
A
A
K
N
Q
A
A
M
N
P
A
N
T
I
F
D
V
K
R
L
I
G
----------------------------
R
RFDD
P
T
V
K
K
D
M
E
S
WP
F
K
V
V
D
D
N-
G
N
------------------------
P
-------------
K
-------------
V
------------------------
E
-----------
V
---
Q
Y
L--
G
-------------
Q
T
H
T
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
T
K
L
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
N
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
S
G
K
S
---
D
K
E
R
N
-
V
L
I
Y
D
L
G
G
G
A
F
D
V
S
L
L
N
I
----
Q
G
----
G
V
F
T
V
K
A
T
A
G
D
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
Y
C
K
K
E
F
T
R
K
T
K
K
D
L
S
G
D
A
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
G
A
Q
T
T
I
E
I
D
S
L
F
D
G
E
----
D
F
N
I
Q
I
T
R
A
R
F
E
D
L
N
A
K
A
F
A
G
T
L
E
P
V
A
Q
V
L
K
D
A
G
I
E
K
H
Q
V
D
E
I
V
L
V
G
G
S
T
R
I
P
R
I
Q
K
L
L
S
E
-
F
-
F
D
G
-
K
-
K
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
I
L
S
G
K----
D
-----
T
S
D
L
L
L
L
D
V
V
P
L
S
L
G
V
A
M
E
G
N
I
F
A
P
V
V
P
R
G
Q
T
V
P
T
I
K
K
R
T
F
T
T
V
A
----
T
V
Q
F
P
V
Y
Q
G
E
R
V
N
C
E
D
N
T
L
L
G
E
F
T
L
A
P
I
P
P
M
K
A
G
E
P
V
L
E
V
V
F
E
V
D
V
N
G
I
L
K
V
T
A
T
E
K
T
S
G
R
S
A
N
I
T
I
A
N
S
V
-
G
K
L
S
T
D
E
I
E
K
M
I
S
D
A
E
K
F
K
S
K
C
E
A
F
S
K
R
F
E
A
K
Q
Q
L
E
S
Y
I
S
R
V
E
E
I
I
---
S
-----------
G
Q
K
D
K
I
E
Q
A
L
S
E
A
M
A
Q
L
E
I
E
D
S
---
T
A
D
E
L
K
K
K
E
L
A
L
K
R
L
V
-------------------------------------------
7
PsiBlast_PDB
64.79
52%
46
- C2 -
-
3C7N
2
HSP7C_BOVIN
B:
[3-547]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
YKG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
-
F
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
K------
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
-
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
---------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
64.62
45%
39
- C2 -
-
5TKY
2
SSB1_CHATD
A:
[17-614]
------
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
G
T
N
V
E
I
I
A
N
E
Q
G
N
F
T
T
P
S
F
V
S
F
-
T
-
E
-
N
C
R
L
I
G
E
A
A
K
N
Q
A
A
M
N
P
A
N
T
I
F
D
V
K
R
L
I
G
----------------------------
R
RFDD
P
T
V
K
K
D
M
E
S
WP
F
K
V
V
D
D
N-
G
N
------------------------
P
-------------
K
-------------
V
------------------------
E
-----------
V
---
Q
YL--
G
-------------
Q
T
H
T
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
T
K
L
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
N
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
GS
G
K
S
---
D
K
E
R
N
-
V
L
I
Y
D
L
G
G
G
A
F
D
V
S
L
L
N
I
----
Q
G
----
G
V
F
T
V
K
A
T
A
G
D
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
Y
C
K
K
E
F
T
R
K
T
K
K
D
L
S
G
D
A
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
G
A
Q
T
T
I
E
I
D
S
L
F
D
G
E
----
D
F
N
I
Q
I
T
R
A
R
F
E
D
L
N
A
K
A
F
A
G
T
L
E
P
V
A
Q
V
L
K
D
A
G
I
E
K
H
Q
V
D
E
I
V
L
V
G
G
S
T
R
I
P
R
I
Q
K
L
L
S
E
-
F
-
F
D
G
-
K
-
K
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
I
L
S
G
KATSA
D
-------
D
L
L
L
L
D
V
V
P
L
S
L
G
V
A
M
E
G
N
I
F
A
P
V
V
P
R
G
Q
T
V
P
T
I
K
K
R
T
F
T
T
V
A
D
N
Q
Q
T
V
Q
F
P
V
Y
Q
G
E
R
V
N
C
E
D
N
T
L
L
G
E
F
T
L
A
P
I
P
P
M
K
A
G
E
P
V
L
E
V
V
F
E
V
D
V
N
G
I
L
K
V
T
A
T
E
K
T
S
G
R
S
A
N
I
T
I
A
N
S
V
-
G
K
L
S
T
D
E
I
E
K
M
I
S
D
A
E
K
F
K
S
K
C
E
A
F
S
K
R
F
E
A
K
Q
Q
L
E
S
Y
I
S
R
V
E
E
I
I
---
S
D
------------
K
D
K
I
E
Q
A
L
S
E
A
M
A
Q
L
E
I
E
D
S
---
T
A
D
E
L
K
K
K
E
L
A
L
K
R
L
V
-------------------------------------------
10
PsiBlast_PDB
64.19
52%
56
- C2 -
-
4FL9
3
HSP7C_BOVIN
A:
[4-553]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
A
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
-
F
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
------------
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
-
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
---------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
55.11
50%
37
- C2 -
-
5AQS
4
HSP7C_HUMAN
A:
[6-386]
M
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
54.89
50%
25
- C2 -
-
3ATV
1
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
----------------------------------------
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
54.49
50%
28
- C2 -
-
3A8Y
1
HS71A_HUMAN
A:
[11-387]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
MKHWP
F
Q
V
I
N
D
GD
K
P
K
V
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
----------------------------------------
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
54.36
50%
28
- C2 -
-
4IO8
1
HS71A_HUMAN
A:
[7-379]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
------------------------
D
-----------
T
----------------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
54.19
50%
25
- C2 -
-
3ATU
2
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
----------------------------------------
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
54.09
50%
22
- C2 -
-
4J8F
1
F10A1_RAT (first)
A:
[14-389]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
----------------------------------------
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
54.00
50%
40
- C2 -
-
5AQS
4
HSP7C_HUMAN
C:
[9-386]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
53.64
50%
25
- C2 -
-
3AY9
1
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
----------------------------------------
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
53.60
50%
24
- C2 -
-
3JXU
1
HS71A_HUMAN
A:
[29-403]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
----------------------------------------
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
53.44
52%
29
- C2 -
-
3I33
2
HSP72_HUMAN
A:
[23-402]
-
M
P
--
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
I
F
D
A
K
R
L
I
G
----------------------------
R
-----------------------
K
F
ED
A
T
V
Q
S
D
M
K
H
-------------
W
-------------
P
-------------
F
R
V
V
S
E
GG
K
P
K
V
Q
V
-----------
E
-----------
Y
KG-
E
----
T
-------------
K
T
F
F
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
GCA
G
G
E
K
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
H
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
-
F
-
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
53.35
50%
39
- C2 -
-
5AQT
7
HSP7C_HUMAN
A:
[6-385]
M
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
53.02
50%
31
- C2 -
-
3A8Y
1
HS71A_HUMAN
B:
[11-385]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
M
K
HWP
F
Q
V
I
N
D
GD
K
P
K
V
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
----------------------------------------
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
--
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
53.02
50%
28
- C2 -
-
5BPM
1
HS71A_HUMAN
A:
[7-381]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
----------------------------------------
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
Q
R
A
K
K
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
53.01
50%
31
- C2 -
-
5BPN
1
HS71A_HUMAN
A:
[7-381]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
-
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
DK
P
K
V
--
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
----------------------------------------
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
--
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
Q
R
A
K
K
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
52.85
50%
34
- C2 -
-
2QWN
1
HSP7C_BOVIN
A:
[3-385]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
KS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
52.81
51%
38
- C2 -
-
3HSC
1
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
52.80
49%
40
- C2 -
-
3IUC
1
GRP78_HUMAN
A:
[28-404]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
----------------------------
R
-----------------------
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
-------------
Q
-------------
V
------------------------
D
-----------
I
---
G
----
G
G
Q
T
----------
K
T
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
R
---
E
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
-
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
52.79
51%
39
- C2 -
-
1NGJ
1
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
52.78
50%
41
- C2 -
-
1ATR
1
HSP7C_BOVIN
A:
[2-383]
-
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
V
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
52.74
50%
39
- C2 -
-
5AQU
9
HSP7C_HUMAN
A:
[6-386]
M
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
52.69
50%
26
- C2 -
-
5BN9
2
HS71A_HUMAN
A:
[7-382]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
----------------------------------------
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
K
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
52.68
50%
28
- C2 -
-
5BPL
2
HS71A_HUMAN
A:
[7-382]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
----------------------------------------
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
K
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
52.64
50%
26
- C2 -
-
2E8A
1
HS71A_HUMAN
A:
[10-385]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
RKFGD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
-----------------------
V
S
------------------------
Y
-------------
K
-------------
G
----------------------------------------
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
52.56
53%
41
- C2 -
-
2V7Z
1
HSP7C_RAT
B:
[2-382]
-
S
K
GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDDAVVQSDMKHWPFMVVN-------
D
-----------------------
A
G
------------------------
R
P------------
K
-------------
V
------------------------
Q
-----------
V
---
E
YKGE
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
A
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
R
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
T
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
-
F
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
52.54
50%
38
- C2 -
-
3FE1
1
HSP76_HUMAN
C:
[24-402]
-
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
RKFAD
T
T
V
Q
S
D
M
K
---------------
H
-----------------------
W
P
------------------------
F
-------------
R
-------------
V
------------------------
V
-----------
S
---
E
----
G
G
K
P
K
V
R
V
C
Y
RG
E
D
K
T
F
Y
--
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
R
---
G
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
----
G
V
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
--
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
52.49
50%
40
- C2 -
-
1NGF
1
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
N
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
52.44
50%
41
- C2 -
-
3LDQ
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
52.41
50%
42
- C2 -
-
3FZM
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
YKG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
52.35
52%
31
- C2 -
-
1QQN
1
HSP7C_BOVIN
A:
[1-377]
-
G
P
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
----------------------------
R
-----------------------
A
F
------------------------
D
-------------
D
-------------
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
A
P
K
V
Q
V
E
-----------
Y
KG-
E
----
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
A
V--
G
A
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
A
H
A
K
D
I
S
E
N
K
R
A
V
R
R
L
A
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
-
F
-
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
52.01
50%
37
- C2 -
-
1NGH
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
N
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
51.99
50%
37
- C2 -
-
1NGD
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
N
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
51.94
50%
42
- C2 -
-
1ATS
1
HSP7C_BOVIN
A:
[2-383]
-
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
E
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
51.92
50%
36
- C2 -
-
2QWO
4
HSP7C_BOVIN
A:
[4-390]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
KSEN-
V
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
51.92
53%
42
- C2 -
-
2V7Z
1
HSP7C_RAT
A:
[2-382]
-
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
KHWP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
A
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
R
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
T
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
-
F
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
51.91
50%
42
- C2 -
-
3FE1
2
HSP76_HUMAN
B:
[23-403]
M
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
RKFAD
T
T
V
Q
S
D
M
K
---------------
H
-----------------------
W
P
------------------------
F
-------------
R
-------------
V
------------------------
V
-----------
S
---
E
----
G
G
K
P
K
V
R
V
C
Y
RG
E
D
K
T
F
Y
--
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
R
---
G
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
----
G
V
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
--
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
51.85
51%
45
- C2 -
-
4H5T
1
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
51.84
52%
37
- C2 -
-
4J8F
1
F10A1_RAT (first)
A:
[11-389]
-
A
A
--
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
----------------------------
R
-----------------------
K
F
------------------------
G
D
P
V
V
Q
S
D
M
K
H
WP
F
Q
-------------
V
------------------------
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG-
E
----
T
-------------
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
T
G--
K
G
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
-
F
-
F
-
N
-
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
51.78
50%
40
- C2 -
-
2QWM
2
HSP7C_BOVIN
B:
[4-384]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDDAVVQSDMKHWPFMVVN-------
D
-----------------------
A
G
------------------------
R
P------------
K
-------------
V
------------------------
Q
-----------
V
---
E
YKGE
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
51.77
51%
41
- C2 -
-
1BA1
1
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
K
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
51.76
50%
37
- C2 -
-
1NGA
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
S
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
51.68
50%
41
- C2 -
-
5AQV
10
HSP7C_HUMAN
A:
[9-386]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
51.66
50%
40
- C2 -
-
1NGG
1
HSP7C_BOVIN
A:
[3-381]
--
K
G
P
A
V
G
I
S
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
51.64
50%
41
- C2 -
-
3FZH
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
51.64
50%
38
- C2 -
-
1NGB
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
Q
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
51.58
50%
42
- C2 -
-
3FE1
1
HSP76_HUMAN
A:
[23-403]
M
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
RKFAD
T
T
V
Q
S
D
M
K
---------------
H
-----------------------
W
P
------------------------
F
-------------
R
-------------
V
------------------------
V
-----------
S
---
E
----
G
G
K
P
K
V
R
V
C
Y
RG
E
D
K
T
F
Y
--
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
R
R
---
G
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
----
G
V
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
--
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
51.57
50%
40
- C2 -
-
2QWR
4
HSP7C_BOVIN
A:
[4-386]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
KSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
51.50
50%
37
- C2 -
-
1NGE
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
51.48
50%
37
- C2 -
-
2QWP
4
HSP7C_BOVIN
A:
[4-389]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
KSEN-
V
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
51.37
51%
39
- C2 -
-
1NGI
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
51.36
50%
38
- C2 -
-
1BUP
1
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
S
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
51.23
51%
40
- C2 -
-
1HPM
1
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
51.18
50%
42
- C2 -
-
2QWQ
4
HSP7C_BOVIN
A:
[4-386]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
KSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
51.11
50%
38
- C2 -
-
1BA0
1
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
K
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
51.08
50%
42
- C2 -
-
3M3Z
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KGE
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
51.05
51%
42
- C2 -
-
4H5N
2
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
51.02
50%
40
- C2 -
-
2QWL
2
HSP7C_BOVIN
B:
[4-384]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDDAVVQSDMKHWPFMVVN-------
D
-----------------------
A
G
------------------------
R
P------------
K
-------------
V
------------------------
Q
-----------
V
---
E
YKGE
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
51.00
51%
42
- C2 -
-
3QFU
1
GRP78_YEAST
A:
[20-394]
-----
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
-
D
-
D
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
T
I
F
D
I
K
R
L
I
G
LKYND
R
S
V
Q
K
D
I
K
H
LP
F
N
V
V
N
K
DG----
K
-----------------------
P
A
------------------------
V
-------------
E
-------------
V
------------------------
S
-----------
V
---
K
----
G
E
K
-----------
K
V
F
T
--
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
S
---
D
K
E
H
Q
-
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
----
E
N
----
G
V
F
E
V
Q
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
H
G
I
D
V
S
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
M
S
T
R
I
E
I
D
S
F
V
D
G
----
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
-
Y
-
F
D
G
-
K
-
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
50.99
50%
41
- C2 -
-
3FZK
2
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
50.98
50%
43
- C2 -
-
3FZF
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
50.98
49%
47
- C2 -
-
3IUC
1
GRP78_HUMAN
C:
[28-406]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
----------------------------
R
-----------------------
T
W
NDPSVQQDIKFLPFKVVEKKTKPY
I
-------------
Q
-------------
V
------------------------
D
-----------
I
---
G
----
G
GQT----------
K
T
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
-----
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
-
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
50.83
50%
39
- C2 -
-
1NGC
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
50.66
51%
46
- C2 -
-
4H5V
4
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
50.53
50%
41
- C2 -
-
2QWL
2
HSP7C_BOVIN
A:
[4-384]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
50.52
50%
40
- C2 -
-
2QWM
2
HSP7C_BOVIN
A:
[4-384]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
50.51
51%
44
- C2 -
-
4H5R
2
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
50.50
50%
43
- C2 -
-
3FZL
2
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
50.29
50%
41
- C2 -
-
1HX1
1
HSP7C_BOVIN
A:
[26-400]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
50.22
51%
43
- C2 -
-
4H5W
1
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
-------
D
-----------------------
A
G
------------------------
R
P
------------
K
-------------
V
------------------------
Q
-----------
V
---
E
Y
KG
E
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
50.06
51%
46
- C2 -
-
4H5R
2
HSP7C_HUMAN
B:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDDAVVQSDMKHWPFMVVN-------
D
-----------------------
A
G
------------------------
R
P------------
K
-------------
V
------------------------
Q
-----------
V
---
E
YKGE
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
49.37
51%
44
- C2 -
-
4H5W
1
HSP7C_HUMAN
B:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
RRFDDAVVQSDMKHWPFMVVN-------
D
-----------------------
A
G
------------------------
R
P------------
K
-------------
V
------------------------
Q
-----------
V
---
E
YKGE
T
-------------
K
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------