@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U2T8: (2017-12-23 )
MFTKCFIINLPYEFTKFYFVCFHHKSKLRFLNYIESTNTILLIKGVFFMTILVLGGAGYIGSHAVDQLVQKGYQVAVVDNLLTGHKQAVHPDAHFYEGDIRDKEFLRSVFEKEPIEGVIHFAASSLVGESVEKPLMYFNNNVYGMQILLEVMHEFNVNKIVFSSTAATYGEPKESPITEDTPANPKNPYGESKLMMEKMMKWCDQAYGMRYVALRYFNVAGAKADASIGEDHTPETHLVPIILQVALGQRKALAVYGDDYDTPDGTCIRDYVQVEDLIAAHILALEYLKEGNESNFFNLGSSKGYSVKEMLEAAREVTGKEIPAEIAPRRAGDPSRLVASSEKAREILGWKPEYTDIKAIIKTAWDWHVSHPNGYEE
Atome Classification :
(42 SA)
.........10........20........30........40........50........60........70-........80-------------....-------..---..---------90------------------.......----..100.......110.-.-.....120.......130.......140.......150.......160.......170--.----.---.......180-.......190.......200----------.--.....--...210-...-.....220.......230.-.-.-.---.---...240.-----......250---.........260.......270.......280.......290-....-.----.----.---..300.......310.......320.......330.......340.......350.......360.......370.....------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MF
T
K
C
F
I
I
NLPYE
F
T
K
F
Y
F
V
C
F
HHKSK
L
R
F
L
N
YIEST
N
T
I
L
L
I
K
G
V
F
F
M
T
I
L
V
LGGAGY
I
G
S
H
A
V
D
Q
L
V
QK-G
Y
Q
V
A
V
V
D
N
L
-------------LTGH-------KQ---AV---------H-------------------PDAHFYE----GDIR
D
K
E
F
L
R
S
V
F
EKE-P-
I
E
G
V
I
H
F
A
A
S
S
L
V
G
E
S
V
EK
P
L
M
Y
FNNNV
Y
G
M
Q
I
L
L
E
V
M
H
EFNV
N
K
I
V
FSSTAATYG----E----P---KESPITEDTP-ANPKNPYG
E
S
K
L
M
M
E
K
M
M
------------
K
--
W
C
D
Q
A
--YG
M
R
Y
--
V
A
L
-
R
Y
F
NVAGAKADASIGED-H-T-P-E---
T
---
H
L
V
P
I
I
L
-----
Q
V
ALGQ
R
-----
K
A
L
A
V
YGDDYDTPD
G
T
C
I
R
D
Y
V
Q
V
E
D
L
I
A
A
H
I
L
A
L
E
Y
L
KE---GNES-N----
F
----
F
---NLGSSKGY
S
V
K
E
M
L
E
A
A
R
E
VTGKEI
P
A
E
IAPRRAG
D
P
S
R
L
VA
S
S
E
K
A
R
E
I
LGWKPE
Y
T
D
I
K
A
I
I
K
T
A
W
D
W
HVSHPNGYEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
95.67
63%
-105
- C1 -
-
2C20
1
?
D:
[3-330]
-------------------------------------------------
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
S
V
V
V
V
D
N
L
-------------
Q
T
G
H
-------
E
D
---
A
I
---------
T
-------------------
E
G
A
K
F
Y
N
----
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
-
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
----
V
---
D
V
D
L
I
T
E
E
T
M
-
T
N
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
--
W
Y
S
Q
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
-
H
-
R
-
P
-
E
---
T
---
H
L
I
P
L
V
L
-----
Q
V
A
L
G
Q
R
-----
E
K
I
M
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
---
G
G
E
S
-
D
----
F
----
Y
---
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.74
63%
-107
- C1 -
-
2C20
1
?
A:
[3-330]
-------------------------------------------------
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
S
V
V
V
V
D
N
L
-------------
Q
T
G
H
-------
E
D
---
A
I
---------
T
-------------------
E
G
A
K
F
Y
N
----
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
-
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
----
V
---
D
V
D
L
I
T
E
E
T
M
-
T
N
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
--
W
Y
S
Q
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
-
H
-
R
-
P
-
E
---
T
---
H
L
I
P
L
V
L
-----
Q
V
A
L
G
Q
R
-----
E
K
I
M
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
---
G
G
E
S
-
D
----
F
----
Y
---
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
93.62
63%
-105
- C1 -
-
2C20
1
?
B:
[3-330]
-------------------------------------------------
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
S
V
V
V
V
D
N
L
-------------
Q
T
G
H
-------
E
D
---
A
I
---------
T
-------------------
E
G
A
K
F
Y
N
----
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
-
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
----
V
---
D
V
D
L
I
T
E
E
T
M
-
T
N
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
--
W
Y
S
Q
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
-
H
-
R
-
P
-
E
---
T
---
H
L
I
P
L
V
L
-----
Q
V
A
L
G
Q
R
-----
E
K
I
M
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
---
G
G
E
S
-
D
----
F
----
Y
---
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
92.53
63%
-106
- C1 -
-
2C20
1
?
C:
[3-330]
-------------------------------------------------
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
S
V
V
V
V
D
N
L
-------------
Q
T
G
H
-------
E
D
---
A
I
---------
T
-------------------
E
G
A
K
F
Y
N
----
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
-
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
----
V
---
D
V
D
L
I
T
E
E
T
M
-
T
N
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
--
W
Y
S
Q
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
-
H
-
R
-
P
-
E
---
T
---
H
L
I
P
L
V
L
-----
Q
V
A
L
G
Q
R
-----
E
K
I
M
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
---
G
G
E
S
-
D
----
F
----
Y
---
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
92.52
64%
-106
- C1 -
-
2C20
1
?
C:
[2-329]
------------------------------------------------
N
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
S
V
V
V
V
D
N
L
-------------
Q
T
G
H
-------
E
D
---
A
I
---------
T
-------------------
E
G
A
K
F
Y
N
----
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
-
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
----
V
---
D
V
D
L
I
T
E
E
T
M
-
T
N
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
--
W
Y
S
Q
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
-
H
-
R
-
P
-
E
---
T
---
H
L
I
P
L
V
L
-----
Q
V
A
L
G
Q
R
-----
E
K
I
M
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
---
G
G
E
S
-
D
----
F
----
Y
---
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
91.68
63%
-104
- C1 -
-
2C20
1
?
F:
[3-330]
-------------------------------------------------
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
S
V
V
V
V
D
N
L
-------------
Q
T
G
H
-------
E
D
---
A
I
---------
T
-------------------
E
G
A
K
F
Y
N
----
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
-
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
----
V
---
D
V
D
L
I
T
E
E
T
M
-
T
N
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
--
W
Y
S
Q
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
-
H
-
R
-
P
-
E
---
T
---
H
L
I
P
L
V
L
-----
Q
V
A
L
G
Q
R
-----
E
K
I
M
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
---
G
G
E
S
-
D
----
F
----
Y
---
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
91.12
63%
-105
- C1 -
-
2C20
1
?
E:
[3-330]
-------------------------------------------------
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
S
V
V
V
V
D
N
L
-------------
Q
T
G
H
-------
E
D
---
A
I
---------
T
-------------------
E
G
A
K
F
Y
N
----
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
-
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
----
V
---
D
V
D
L
I
T
E
E
T
M
-
T
N
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
--
W
Y
S
Q
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
-
H
-
R
-
P
-
E
---
T
---
H
L
I
P
L
V
L
-----
Q
V
A
L
G
Q
R
-----
E
K
I
M
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
---
G
G
E
S
-
D
----
F
----
Y
---
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
84.70
47%
-96
- C1 -
-
4WOK
1
?
A:
[11-332]
-----------------------------------------------
A
N
N
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
A
G
Q
-
G
Y
A
P
V
V
Y
D
N
L
-------------
S
T
G
H
-------
Q
----
S
A
---------
V
-------------------
R
W
G
D
F
V
E
----
G
D
I
L
D
Q
A
R
L
V
E
T
M
E
K
Y
-
A
-
P
V
A
V
I
H
F
A
A
S
A
Y
V
G
E
S
V
E
D
P
A
K
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
D
A
C
R
L
T
R
T
Q
N
V
I
F
S
S
S
C
A
T
Y
G
----
V
----
P
---
S
R
L
P
I
G
E
G
E
A
-
Q
N
P
I
N
P
Y
G
R
T
K
L
I
A
E
H
M
L
------------
A
--
D
Y
A
V
A
--
Y
G
L
R
Y
--
V
A
L
-
R
Y
F
N
A
S
G
A
D
I
D
G
E
L
G
E
K
-
H
-
D
-
P
-
E
---
T
---
H
L
I
P
R
A
M
-----
M
A
A
A
G
R
L
-----
D
V
L
E
V
Y
G
D
D
Y
E
T
P
D
G
T
C
I
R
D
Y
I
H
V
T
D
L
A
R
A
H
V
L
A
V
E
H
L
K
E
---
A
G
G
N
-
L
----
A
----
V
---
N
L
G
T
G
R
G
T
S
I
R
E
I
V
Q
S
I
G
R
L
T
G
R
S
V
P
V
A
M
R
A
R
R
A
G
D
P
P
A
L
Y
A
D
P
A
L
A
A
E
K
L
G
F
H
T
V
Y
S
D
L
D
T
I
I
R
T
A
A
P
H
F
G
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.15
49%
-98
- C1 -
-
4WOK
1
?
A:
[14-326]
--------------------------------------------------
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
A
G
Q
-
G
Y
A
P
V
V
Y
D
N
L
-------------
S
T
G
H
-------
Q
S
---
A
V
---------
R
-------------------
W
-
G
D
F
V
E
----
G
D
I
L
D
Q
A
R
L
V
E
T
M
E
K
Y
-
A
-
P
V
A
V
I
H
F
A
A
S
A
Y
V
G
E
S
V
E
D
P
A
K
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
D
A
C
R
L
T
R
T
Q
N
V
I
F
S
S
S
C
A
T
Y
G
----
V
----
P
---
S
R
L
P
I
G
E
G
E
A
-
Q
N
P
I
N
P
Y
G
R
T
K
L
I
A
E
H
M
L
------------
A
--
D
Y
A
V
A
--
Y
G
L
R
Y
--
V
A
L
-
R
Y
F
N
A
S
G
A
D
I
D
G
E
L
G
E
K
-
H
-
D
-
P
-
E
---
T
---
H
L
I
P
R
A
M
-----
M
A
A
A
G
R
L
-----
D
V
L
E
V
Y
G
D
D
Y
E
T
P
D
G
T
C
I
R
D
Y
I
H
V
T
D
L
A
R
A
H
V
L
A
V
E
H
L
K
E
---
A
G
G
N
-
L
----
A
----
V
---
N
L
G
T
G
R
G
T
S
I
R
E
I
V
Q
S
I
G
R
L
T
G
R
S
V
P
V
A
M
R
A
R
R
A
G
D
P
P
A
L
Y
A
D
P
A
L
A
A
E
K
L
G
F
H
T
V
Y
S
D
L
D
T
I
I
R
T
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.68
49%
-98
- C1 -
-
4TWR
1
?
A:
[14-326]
--------------------------------------------------
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
A
G
Q
-
G
Y
A
P
V
V
Y
D
N
L
-------------
S
T
G
H
-------
Q
S
---
A
V
---------
R
-------------------
W
-
G
D
F
V
E
----
G
D
I
L
D
Q
A
R
L
V
E
T
M
E
K
Y
-
A
-
P
V
A
V
I
H
F
A
A
S
A
Y
V
G
E
S
V
E
D
P
A
K
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
D
A
C
R
L
T
R
T
Q
N
V
I
F
S
S
S
C
A
T
Y
G
----
V
----
P
---
S
R
L
P
I
G
E
G
E
A
-
Q
N
P
I
N
P
Y
G
R
T
K
L
I
A
E
H
M
L
------------
A
--
D
Y
A
V
A
--
Y
G
L
R
Y
--
V
A
L
-
R
Y
F
N
A
S
G
A
D
I
D
G
E
L
G
E
K
-
H
-
D
-
P
-
E
---
T
---
H
L
I
P
R
A
M
-----
M
A
A
A
G
R
L
-----
D
V
L
E
V
Y
G
D
D
Y
E
T
P
D
G
T
C
I
R
D
Y
I
H
V
T
D
L
A
R
A
H
V
L
A
V
E
H
L
K
E
---
A
G
G
N
-
L
----
A
----
V
---
N
L
G
T
G
R
G
T
S
I
R
E
I
V
Q
S
I
G
R
L
T
G
R
S
V
P
V
A
M
R
A
R
R
A
G
D
P
P
A
L
Y
A
D
P
A
L
A
A
E
K
L
G
F
H
T
V
Y
S
D
L
D
T
I
I
R
T
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
68.99
43%
-8
- C1 -
-
2CNB
2
?
A:
[3-382]
------------------------------------------------
M
R
V
L
V
C
G
G
A
G
Y
I
G
S
H
F
V
R
A
L
L
R
D
T
N
H
S
V
V
I
V
D
S
L
-------------
V
G
T
H
-------
G
K
---
S
D
---------
H
VET
R
E
N
V
A
R
K
L
Q
Q
SDGPKP
P
W
A
D
R
Y
A
A
L
E
V
G
D
V
R
N
E
D
F
L
N
G
V
F
T
R
H
G
P
-
I
D
A
V
V
H
M
C
A
F
L
A
V
G
E
S
V
R
D
P
L
K
Y
Y
D
N
N
V
V
G
I
L
R
L
L
Q
A
M
L
L
H
K
C
D
K
I
I
F
S
S
S
A
A
I
F
G
----
N
----
P
T--
N
A
E
P
I
D
I
N
A
K
-
K
S
P
E
S
P
Y
G
E
S
K
L
I
A
E
R
M
I
------------
R
--
D
C
A
E
A
--
Y
G
I
K
G
--
I
C
L
-
R
Y
F
N
A
C
G
A
H
E
D
G
D
I
G
E
H
-
Y
-
Q
-
G
-
S
---
T
---
H
L
I
P
I
I
L
G
R
V
M
S
D
I
A
P
D
--D----
K
R
M
P
I
F
G
T
D
Y
P
T
P
D
G
T
C
V
R
D
Y
V
H
V
C
D
L
A
S
A
H
I
L
A
L
D
Y
V
E
K
LGP
N
D
K
S
-
K
----
Y
----
F
S
V
F
N
L
G
T
S
R
G
Y
S
V
R
E
V
I
E
V
A
R
K
T
T
G
H
P
I
P
V
R
E
C
G
R
R
E
G
D
P
A
Y
L
V
A
A
S
D
K
A
R
E
V
L
G
W
K
P
K
Y
D
T
L
E
A
I
M
E
T
S
W
K
F
Q
R
T
H
P
N
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.88
43%
-14
- C1 -
-
1GY8
2
?
A:
[3-382]
------------------------------------------------
M
R
V
L
V
C
G
G
A
G
Y
I
G
S
H
F
V
R
A
L
L
R
D
T
N
H
S
V
V
I
V
D
S
L
-------------
V
G
T
H
-------
G
K
---
S
D
---------
H
VET
R
E
N
V
A
R
K
L
Q
Q
S
DGPKP
P
W
A
D
R
Y
A
A
L
E
V
G
D
V
R
N
E
D
F
L
N
G
V
F
T
R
H
G
P
-
I
D
A
V
V
H
M
C
A
F
L
A
V
G
E
S
V
R
D
P
L
K
Y
Y
D
N
N
V
V
G
I
L
R
L
L
Q
A
M
L
L
H
K
C
D
K
I
I
F
S
S
S
A
A
I
F
G
----
N
----
P
TM-
N
A
E
P
I
D
I
N
A
K
-
K
S
P
E
S
P
Y
G
E
S
K
L
I
A
E
R
M
I
------------
R
--
D
C
A
E
A
--
Y
G
I
K
G
--
I
C
L
-
R
Y
F
N
A
C
G
A
H
E
D
G
D
I
G
E
H
-
Y
-
Q
-
G
-
S
---
T
---
H
L
I
P
I
I
L
G
R
V
M
S
D
I
A
P
D
--D----
K
R
M
P
I
F
G
T
D
Y
P
T
P
D
G
T
C
V
R
D
Y
V
H
V
C
D
L
A
S
A
H
I
L
A
L
D
Y
V
E
K
LGP
N
D
K
S
-
K
----
Y
----
F
S
V
F
N
L
G
T
S
R
G
Y
S
V
R
E
V
I
E
V
A
R
K
T
T
G
H
P
I
P
V
R
E
C
G
R
R
E
G
D
P
A
Y
L
V
A
A
S
D
K
A
R
E
V
L
G
W
K
P
K
Y
D
T
L
E
A
I
M
E
T
S
W
K
F
Q
R
T
H
P
N
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
68.52
43%
-13
- C1 -
-
1GY8
2
?
C:
[3-382]
------------------------------------------------
M
R
V
L
V
C
G
G
A
G
Y
I
G
S
H
F
V
R
A
L
L
R
D
T
N
H
S
V
V
I
V
D
S
L
-------------
V
G
T
H
-------
G
K
---
S
D
---------
H
VET
R
E
N
V
A
R
K
L
Q
Q
S
DGPKP
P
W
A
D
R
Y
A
A
L
E
V
G
D
V
R
N
E
D
F
L
N
G
V
F
T
R
H
G
P
-
I
D
A
V
V
H
M
C
A
F
L
A
V
G
E
S
V
R
D
P
L
K
Y
Y
D
N
N
V
V
G
I
L
R
L
L
Q
A
M
L
L
H
K
C
D
K
I
I
F
S
S
S
A
A
I
F
G
----
N
----
P
TM-
N
A
E
P
I
D
I
N
A
K
-
K
S
P
E
S
P
Y
G
E
S
K
L
I
A
E
R
M
I
------------
R
--
D
C
A
E
A
--
Y
G
I
K
G
--
I
C
L
-
R
Y
F
N
A
C
G
A
H
E
D
G
D
I
G
E
H
-
Y
-
Q
-
G
-
S
---
T
---
H
L
I
P
I
I
L
G
R
V
M
S
D
I
A
P
---DASTD
K
R
M
P
I
F
G
T
D
Y
P
T
P
D
G
T
C
V
R
D
Y
V
H
V
C
D
L
A
S
A
H
I
L
A
L
D
Y
V
E
K
LGP
N
D
K
S
-
K
----
Y
----
F
S
V
F
N
L
G
T
S
R
G
Y
S
V
R
E
V
I
E
V
A
R
K
T
T
G
H
P
I
P
V
R
E
C
G
R
R
E
G
D
P
A
Y
L
V
A
A
S
D
K
A
R
E
V
L
G
W
K
P
K
Y
D
T
L
E
A
I
M
E
T
S
W
K
F
Q
R
T
H
P
N
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
68.11
43%
-13
- C1 -
-
1GY8
2
?
B:
[3-382]
------------------------------------------------
M
R
V
L
V
C
G
G
A
G
Y
I
G
S
H
F
V
R
A
L
L
R
D
T
N
H
S
V
V
I
V
D
S
L
-------------
V
G
T
H
-------
G
K
---
S
D
---------
H
VET
R
E
N
V
A
R
K
L
Q
Q
SDGPKP
P
W
A
D
R
Y
A
A
L
E
V
G
D
V
R
N
E
D
F
L
N
G
V
F
T
R
H
G
P
-
I
D
A
V
V
H
M
C
A
F
L
A
V
G
E
S
V
R
D
P
L
K
Y
Y
D
N
N
V
V
G
I
L
R
L
L
Q
A
M
L
L
H
K
C
D
K
I
I
F
S
S
S
A
A
I
F
G
----
N
----
P
TMT
N
A
E
P
I
D
I
N
A
K
-
K
S
P
E
S
P
Y
G
E
S
K
L
I
A
E
R
M
I
------------
R
--
D
C
A
E
A
--
Y
G
I
K
G
--
I
C
L
-
R
Y
F
N
A
C
G
A
H
E
D
G
D
I
G
E
H
-
Y
-
Q
-
G
-
S
---
T
---
H
L
I
P
I
I
L
G
R
V
M
S
D
I
A
----D----
K
R
M
P
I
F
G
T
D
Y
P
T
P
D
G
T
C
V
R
D
Y
V
H
V
C
D
L
A
S
A
H
I
L
A
L
D
Y
V
E
K
LGP
N
D
K
S
-
K
----
Y
----
F
S
V
F
N
L
G
T
S
R
G
Y
S
V
R
E
V
I
E
V
A
R
K
T
T
G
H
P
I
P
V
R
E
C
G
R
R
E
G
D
P
A
Y
L
V
A
A
S
D
K
A
R
E
V
L
G
W
K
P
K
Y
D
T
L
E
A
I
M
E
T
S
W
K
F
Q
R
T
H
P
N
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
67.66
43%
-11
- C1 -
-
2CNB
2
?
D:
[3-382]
------------------------------------------------
M
R
V
L
V
C
G
G
A
G
Y
I
G
S
H
F
V
R
A
L
L
R
D
T
N
H
S
V
V
I
V
D
S
L
-------------
V
G
T
H
-------
G
K
---
S
D
---------
H
VET
R
E
N
V
A
R
K
L
Q
Q
SDGPKP
P
W
A
D
R
Y
A
A
L
E
V
G
D
V
R
N
E
D
F
L
N
G
V
F
T
R
H
G
P
-
I
D
A
V
V
H
M
C
A
F
L
A
V
G
E
S
V
R
D
P
L
K
Y
Y
D
N
N
V
V
G
I
L
R
L
L
Q
A
M
L
L
H
K
C
D
K
I
I
F
S
S
S
A
A
I
F
G
----
N
----
P
T--
N
A
E
P
I
D
I
N
A
K
-
K
S
P
E
S
P
Y
G
E
S
K
L
I
A
E
R
M
I
------------
R
--
D
C
A
E
A
--
Y
G
I
K
G
--
I
C
L
-
R
Y
F
N
A
C
G
A
H
E
D
G
D
I
G
E
H
-
Y
-
Q
-
G
-
S
---
T
---
H
L
I
P
I
I
L
G
R
V
M
S
D
I
A
----D----
K
R
M
P
I
F
G
T
D
Y
P
T
P
D
G
T
C
V
R
D
Y
V
H
V
C
D
L
A
S
A
H
I
L
A
L
D
Y
V
E
K
LGP
N
D
K
S
-
K
----
Y
----
F
S
V
F
N
L
G
T
S
R
G
Y
S
V
R
E
V
I
E
V
A
R
K
T
T
G
H
P
I
P
V
R
E
C
G
R
R
E
G
D
P
A
Y
L
V
A
A
S
D
K
A
R
E
V
L
G
W
K
P
K
Y
D
T
L
E
A
I
M
E
T
S
W
K
F
Q
R
T
H
P
N
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.01
42%
15
- C1 -
-
3ENK
2
?
A:
[7-340]
-------------------------------------------------
T
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
-
G
Y
D
V
V
I
A
D
N
L
-------------
V
N
S
K
-------
R
E
---
A
I
---------
A
R
I
E
K
I
TG------------
K
T
P
A
F
H
E
----
T
D
V
S
D
E
R
A
L
A
R
I
F
D
A
H
-
P
-
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
G
----
V
----
P
---
E
R
S
P
I
D
E
T
F
P
-
L
S
A
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
------------
R
--
D
V
E
A
A
D-
P
S
W
R
V
--
A
T
L
-
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
D
-
P
-
A
-
G
I
P
---
N
---
N
L
M
P
Y
V
A
-----
Q
V
A
V
G
K
L
-----
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
E
R
---
R
D
A
S
-
L
----
T
----
V
---
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
-
R
D
L
E
R
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Fugue
66.85
41%
7
- C1 -
-
1Z45
3
GAL10_YEAST
A:
[11-699]
-----------------------------------------------
S
K
I
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
N
-
G
Y
D
C
V
V
A
D
N
L
-------------
S
N
S
T
Y
D
S
V
A
R
L
E
V
---
L
T
---------
K
-------------------
H
H
I
P
F
Y
E
----
V
D
L
C
D
R
K
G
L
E
K
V
F
K
E
Y
-
K
-
I
D
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
P
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
Q
Q
Y
N
V
S
K
F
V
F
S
S
S
A
T
V
Y
G
DATR
F
----
P
---
N
M
I
P
I
P
E
E
C
P
-
L
G
P
T
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
------------
N
--
D
L
Y
N
S
D
K
K
S
W
K
F
--
A
I
L
-
R
Y
F
N
P
I
G
A
H
P
S
G
L
I
G
E
D
-
P
-
L
G
I
-
P
---
N
---
N
L
L
P
Y
M
A
-----
Q
V
A
V
G
R
R
-----
E
K
L
Y
I
F
------
R
D
G
T
P
I
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
Q
Y
L
E
A
---
Y
N
E
N
-
E
G
L
C
R
E
----
W
---
N
L
G
S
G
K
G
S
T
V
F
E
V
Y
H
A
F
C
K
A
S
G
I
D
L
P
Y
V
L
N
---------
L
T
A
K
P
D
R
A
K
R
E
L
K
W
Q
T
E
L
-
Q
V
E
D
S
C
K
D
L
W
K
W
T
T
E
N
P
F
G
Y
Q
L
RG
V
E
A
R
F
SAEDMRYDA
R
F
V
T
I
GAGTR
F
Q
A
T
F
A
NLGASIV
D
L
K
V
NGQSV
V
L
G
Y
EN
E
E
G
Y
L
NPDSAYIGATIGRYANRISKG
K
F
S
L
CN
K
D
Y
Q
L
TVNNGVNANHSSIGSFHR
K
R
F
L
G
P
I
I
Q
NPSKD
V
F
T
A
E
Y
M
L
I
D
N
EKDTEFP
G
D
L
L
V
T
I
Q
Y
T
V
N
VAQK
S
L
E
I
V
Y
K
G
K
L
TAGE
A
T
P
I
N
L
T
N
H
S
Y
F
N
LNKPYGDTIEG
T
E
I
M
V
RSK
K
S
V
D
V
D
KNMIPTG
N
I
V
D
R
EIATFNSTK
P
T
V
L
G
PKNP
Q
F
D
C
C
F
V
VDENAKPSQINTLNNELTLI
V
K
A
F
H
PDSN
I
T
L
E
V
L
S
TEP
T
Y
Q
F
Y
TGDFLSAGYEARQ
G
F
A
I
E
P
G
RYIDAINQENWKDCVTLKNG
E
T
Y
G
S
K
I
V
Y
R
F
S
27
PsiBlast_CBE
65.50
43%
-8
- C1 -
-
1GY8
2
?
D:
[3-382]
------------------------------------------------
M
R
V
L
V
C
G
G
A
G
Y
I
G
S
H
F
V
R
A
L
L
R
D
T
N
H
S
V
V
I
V
D
S
L
-------------
V
G
T
H
-------
G
K
---
S
D
---------
H
VET
R
E
N
V
A
R
K
L
Q
Q
SDGPKP
P
W
A
D
R
Y
A
A
L
E
V
G
D
V
R
N
E
D
F
L
N
G
V
F
T
R
H
G
P
-
I
D
A
V
V
H
M
C
A
F
L
A
V
G
E
S
V
R
D
P
L
K
Y
Y
D
N
N
V
V
G
I
L
R
L
L
Q
A
M
L
L
H
K
C
D
K
I
I
F
S
S
S
A
A
I
F
G
----
N
----
P
T--
N
A
E
P
I
D
I
N
A
K
-
K
S
P
E
S
P
Y
G
E
S
K
L
I
A
E
R
M
I
------------
R
--
D
C
A
E
A
--
Y
G
I
K
G
--
I
C
L
-
R
Y
F
N
A
C
G
A
H
E
D
G
D
I
G
E
H
-
Y
-
Q
-
G
-
S
---
T
---
H
L
I
P
I
I
L
G
R
V
M
S
D
I
A
----D----
K
R
M
P
I
F
G
T
D
Y
P
T
P
D
G
T
C
V
R
D
Y
V
H
V
C
D
L
A
S
A
H
I
L
A
L
D
Y
V
E
K
LGP
N
D
K
S
-
K
----
Y
----
F
S
V
F
N
L
G
T
S
R
G
Y
S
V
R
E
V
I
E
V
A
R
K
T
T
G
H
P
I
P
V
R
E
C
G
R
R
E
G
D
P
A
Y
L
V
A
A
S
D
K
A
R
E
V
L
G
W
K
P
K
Y
D
T
L
E
A
I
M
E
T
S
W
K
F
Q
R
T
H
P
N
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
65.30
39%
-1
- C1 -
-
4LIS
2
?
B:
[5-359]
-------------------------------------------------
S
V
L
V
T
G
G
T
G
Y
I
G
S
F
T
T
L
A
L
L
E
A
-
G
Y
K
V
V
V
A
D
N
L
-------------
Y
N
S
S
-------
A
E
---
A
L
---------
N
R
I
E
L
I
SG------------
K
K
A
E
F
A
Q
----
L
D
V
T
D
E
A
A
F
D
K
V
F
E
A
H
-
P
D
I
D
S
V
I
H
F
A
A
L
K
A
V
G
E
S
G
E
K
P
L
D
Y
Y
H
V
N
V
Y
G
T
I
C
L
L
R
S
M
V
R
H
N
V
T
N
I
V
F
S
S
S
A
T
V
Y
G
----
D
ATRF
P
---
D
M
I
P
I
P
E
H
C
P
-
L
G
P
T
N
P
Y
G
N
T
K
F
A
I
E
L
A
I
T
D
V
I
N
A
Q
R
N
N
A
K
K
--
A
G
N
E
T
--
E
A
A
K
W
N
G
A
L
L
-
R
Y
F
N
P
A
G
A
H
P
S
G
I
M
G
E
D
-----
P
-
Q
---
G
VPY
N
L
L
P
L
L
A
-----
Q
V
A
T
G
K
R
-----
E
K
L
L
V
F
G
D
D
Y
A
S
H
D
G
T
A
I
R
D
Y
I
H
I
L
D
L
A
D
G
H
L
K
A
L
N
Y
L
R
A
---
N
N
P
G
V
R
----
A
----
W
---
N
L
G
T
G
R
G
S
T
V
Y
E
M
I
R
A
F
S
K
A
V
G
R
D
L
P
Y
E
V
A
P
R
R
A
G
D
V
L
N
L
T
S
N
P
T
R
A
N
T
E
L
G
W
K
A
Q
R
T
-
L
E
Q
A
C
E
D
L
W
L
W
T
K
N
N
P
Q
G
Y
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
65.25
39%
-4
- C1 -
-
4LIS
3
?
A:
[5-359]
-------------------------------------------------
S
V
L
V
T
G
G
T
G
Y
I
G
S
F
T
T
L
A
L
L
E
A
-
G
Y
K
V
V
V
A
D
N
L
-------------
Y
N
S
S
-------
A
E
---
A
L
---------
N
R
I
E
L
I
SG------------
K
K
A
E
F
A
Q
----
L
D
V
T
D
E
A
A
F
D
K
V
F
E
A
H
-
P
D
I
D
S
V
I
H
F
A
A
L
K
A
V
G
E
S
G
E
K
P
L
D
Y
Y
H
V
N
V
Y
G
T
I
C
L
L
R
S
M
V
R
H
N
V
T
N
I
V
F
S
S
S
A
T
V
Y
G
----
D
ATRF
P
---
D
M
I
P
I
P
E
H
C
P
-
L
G
P
T
N
P
Y
G
N
T
K
F
A
I
E
L
A
I
T
D
V
I
N
A
Q
R
N
N
A
K
K
--
A
G
N
E
T
--
E
A
A
K
W
N
G
A
L
L
-
R
Y
F
N
P
A
G
A
H
P
S
G
I
M
G
E
D
-----
P
-
Q
---
G
VPY
N
L
L
P
L
L
A
-----
Q
V
A
T
G
K
R
-----
E
K
L
L
V
F
G
D
D
Y
A
S
H
D
G
T
A
I
R
D
Y
I
H
I
L
D
L
A
D
G
H
L
K
A
L
N
Y
L
R
A
---
N
N
P
G
V
R
----
A
----
W
---
N
L
G
T
G
R
G
S
T
V
Y
E
M
I
R
A
F
S
K
A
V
G
R
D
L
P
Y
E
V
A
P
R
R
A
G
D
V
L
N
L
T
S
N
P
T
R
A
N
T
E
L
G
W
K
A
Q
R
T
-
L
E
Q
A
C
E
D
L
W
L
W
T
K
N
N
P
Q
G
Y
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
65.02
40%
-1
- C1 -
-
1I3L
3
GALE_HUMAN
A:
[5-344]
--------------------------------------------------
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
V
I
D
N
F
HN
A
F
R
G
GGSLP
E
S
L
R
R
V
-------
Q
E
---
L
T
---------
G
-------------------
R
S
V
E
F
E
E
----
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
-
S
-
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
----
P
---
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D
-
L
C
Q
A
D
--
K
T
W
N
V
--
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
V
S
-----
Q
V
A
I
G
R
R
-----
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
---
Q
C
G
C
-
R
----
I
----
Y
---
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
64.69
42%
15
- C1 -
-
3ENK
2
?
B:
[7-340]
-------------------------------------------------
T
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
-
G
Y
D
V
V
I
A
D
N
L
-------------
V
N
S
K
-------
R
E
---
A
I
---------
A
RIEKITG------------
K
T
P
A
F
H
E
----
T
D
V
S
D
E
R
A
L
A
R
I
F
D
A
H
-
P
-
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
G
----
V
----
P
---
E
R
S
P
I
D
E
T
F
P
-
L
S
A
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
------------
R
--
D
V
E
A
A
D-
P
S
W
R
V
--
A
T
L
-
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
D
-
P
-
A
-
G
I
P
---
N
---
N
L
M
P
Y
V
A
-----
Q
V
A
V
G
K
L
-----
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
E
R
---
R
D
A
S
-
L
----
T
----
V
---
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
-
R
D
L
E
R
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
64.11
40%
1
- C1 -
-
1HZJ
2
GALE_HUMAN
B:
[5-344]
--------------------------------------------------
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
V
I
D
N
F
HNAFRGGGSLPES
L
R
R
V
-------
Q
E
---
L
T
---------
G
-------------------
R
S
V
E
F
E
E
----
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
-
S
-
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
----
P
---
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D-
L
C
Q
A
D
--
K
T
W
N
V
--
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
V
S
-----
Q
V
A
I
G
R
R
-----
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
---
Q
C
G
C
-
R
----
I
----
Y
---
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
64.04
39%
-1
- C1 -
-
1XEL
4
GALE_ECOLI
A:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
---
V
L
P
V
I
E
R
L
G
G
K
H
-------------------
P
T
--
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
----
N
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
64.02
39%
-2
- C1 -
-
1NAH
4
GALE_ECOLI
A:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
---
V
L
P
V
I
E
R
L
G
G
K
H
-------------------
P
T
--
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
----
N
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
63.94
39%
-1
- C1 -
-
1UDC
6
GALE_ECOLI
A:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
---
V
L
P
V
I
E
R
L
G
G
K
H
-------------------
P
T
--
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
----
Q
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
63.90
40%
3
- C1 -
-
1EK6
2
GALE_HUMAN
B:
[5-344]
--------------------------------------------------
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
V
I
D
N
F
HN
A
F
R
G
GGSLP
E
S
L
R
R
V
-------
Q
E
---
L
T
---------
G
-------------------
R
S
V
E
F
E
E
----
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
-
S
-
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
----
P
---
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D
-
L
C
Q
A
D
--
K
T
W
N
A
--
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
V
S
-----
Q
V
A
I
G
R
R
-----
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
---
Q
C
G
C
-
R
----
I
----
Y
---
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
63.84
39%
0
- C1 -
-
1UDB
4
GALE_ECOLI
A:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
---
V
L
P
V
I
E
R
L
G
G
K
H
-------------------
P
T
--
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
----
N
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
63.81
39%
-1
- C1 -
-
1NAI
4
GALE_ECOLI
A:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
---
V
L
P
V
I
E
R
L
G
G
K
H
-------------------
P
T
--
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
----
N
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
63.72
39%
0
- C1 -
-
1UDA
4
GALE_ECOLI
A:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
---
V
L
P
V
I
E
R
L
G
G
K
H
-------------------
P
T
--
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
----
N
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
63.50
39%
-2
- C1 -
-
1A9Z
3
GALE_ECOLI
A:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
---
V
L
P
V
I
E
R
L
G
G
K
H
-------------------
P
T
--
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
----
D
----
N
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
63.49
39%
2
- C1 -
-
1KVT
3
GALE_ECOLI
A:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
---
V
L
P
V
I
E
R
L
G
G
K
H
-------------------
P
T
--
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
V
A
T
V
Y
G
----
D
----
N
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.46
39%
-3
- C1 -
-
1LRK
3
GALE_ECOLI
A:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
---
V
L
P
V
I
E
R
L
G
G
K
H
-------------------
P
T
--
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
----
N
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
C
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
63.45
39%
1
- C1 -
-
2UDP
2
GALE_ECOLI
B:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
---
V
L
PVIERLGGK
H
-------------------
P
T
--
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
----
Q
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
63.31
40%
16
- C1 -
-
1A9Y
2
GALE_ECOLI
A:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
V
L
P
V
I
E
R
L
G
-----
G
-------------------
K
H
P
T
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
----
D
----
Q
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
Q
-
P
D
W
S
I
--
A
L
L
-
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
-
P
Q
G
-
I
-
P
---
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.28
40%
-0
- C1 -
-
1EK6
2
GALE_HUMAN
A:
[5-344]
--------------------------------------------------
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
V
I
D
N
F
HN
A
F
R
G
GGSLP
E
S
L
R
R
V
-------
Q
E
---
L
T
---------
G
-------------------
R
S
V
E
F
E
E
----
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
-
S
-
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
----
P
---
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D
-
L
C
Q
A
D
--
K
T
W
N
A
--
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
V
S
-----
Q
V
A
I
G
R
R
-----
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
---
Q
C
G
C
-
R
----
I
----
Y
---
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
62.96
39%
-1
- C1 -
-
1KVR
4
GALE_ECOLI
A:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
---
V
L
P
V
I
E
R
L
G
G
K
H
-------------------
P
T
--
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
----
D
----
Q
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
62.91
40%
-0
- C1 -
-
1I3N
2
GALE_HUMAN
B:
[5-344]
--------------------------------------------------
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
V
I
D
N
F
HNAFRGGGSLPES
L
R
R
V
-------
Q
E
---
L
T
---------
G
-------------------
R
S
V
E
F
E
E
----
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
-
S
-
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
----
P
---
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D-
L
C
Q
A
D
--
K
T
W
N
V
--
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
V
S
-----
Q
V
A
I
G
R
R
-----
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
---
Q
C
G
C
-
R
----
I
----
Y
---
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
62.84
40%
-1
- C1 -
-
1I3M
2
GALE_HUMAN
B:
[5-344]
--------------------------------------------------
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
V
I
D
N
F
HNAFRGGGSLPES
L
R
R
V
-------
Q
E
---
L
T
---------
G
-------------------
R
S
V
E
F
E
E
----
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
-
S
-
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
----
P
---
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D-
L
C
Q
A
D
--
K
T
W
N
V
--
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
V
S
-----
Q
V
A
I
G
R
R
-----
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
---
Q
C
G
C
-
R
----
I
----
Y
---
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.74
40%
-1
- C1 -
-
1HZJ
2
GALE_HUMAN
A:
[5-344]
--------------------------------------------------
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
V
I
D
N
F
HNAFRGGGSLP
E
S
L
R
R
V
-------
Q
E
---
L
T
---------
G
-------------------
R
S
V
E
F
E
E
----
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
-
S
-
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
----
P
---
Q
Y
L
P
L
D
E
A
H
P
T
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D
-
L
C
Q
A
D
--
K
T
W
N
V
--
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
Q
-
G
-
I
-
P
---
N
---
N
L
M
P
Y
V
S
-----
Q
V
A
I
G
R
R
-----
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
---
Q
C
G
C
-
R
----
I
----
Y
---
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
61.12
39%
4
- C1 -
-
1KVS
3
GALE_ECOLI
A:
[1-338]
------------------------------------------------
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
V
I
I
L
D
N
L
-------------
C
N
S
K
-------
R
S
---
V
L
P
V
I
E
R
L
G
G
K
H
-------------------
P
T
--
F
V
E
----
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
T
A
T
V
Y
G
----
D
----
N
---
P
K
I
P
Y
V
E
S
F
P
T
G
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
--
D
L
Q
K
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
-----
P
-
Q
G
IP
N
---
N
L
M
P
Y
I
A
-----
Q
V
A
V
G
R
R
-----
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
---
K
P
G
V
-
H
----
I
----
Y
---
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
58.81
40%
15
- C1 -
-
1Z45
2
GAL10_YEAST
A:
[14-356]
--------------------------------------------------
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
N
-
G
Y
D
C
V
V
A
D
N
L
-------------
S
N
S
T
-------
Y
D
---
S
V
A
R
L
E
V
L
T
--
K
-------------------
H
H
I
P
F
Y
E
----
V
D
L
C
D
R
K
G
L
E
K
V
F
K
E
Y
-
K
-
I
D
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
P
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
Q
Q
Y
N
V
S
K
F
V
F
S
S
S
A
T
V
Y
G
----
D
ATRF
P
---
N
M
I
P
I
P
E
E
C
P
-
L
G
P
T
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
------------
N
D
L
Y
N
S
D
K
--
K
S
W
K
F
--
A
I
L
-
R
Y
F
N
P
I
G
A
H
P
S
G
L
I
G
E
D
-
P
-
L
-
G
I
P
---
N
---
N
L
L
P
Y
M
A
-----
Q
V
A
V
G
R
R
-----
E
K
L
Y
I
F
------
R
D
G
T
P
I
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
Q
Y
L
E
A
---
Y
N
E
N
-
E
----
G
L
C
R
E
W
---
N
L
G
S
G
K
G
S
T
V
F
E
V
Y
H
A
F
C
K
A
S
G
I
D
L
P
Y
---------
V
L
N
L
T
A
K
P
D
R
A
K
R
E
L
K
W
Q
T
E
L
-
Q
V
E
D
S
C
K
D
L
W
K
W
T
T
E
N
P
F
G
Y
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------