@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U370: (2017-12-24 )
MAKQARKRILIGGGSEQPMRKKMLFIPFALLLSACSSVTQESDNTHLSSSISETVTSPEKSSTKTASTTEQTMATSNNEKKTALDQLKEQQPNVPMPLDVPVSSGYLNIAATHTKQGYSILYYRTDRPLGLNADELNQETPIATYLYQYGFASSQETIQVLQPFEIDTNGQQVDLGSRITGYQQGAAGSSFLEWQEGNWRIRIRGNNIEGQDPLLLAKEIVAYLEENSLPAPEQFGKITVDMGDTTNRAVEVSWQEPKNAYTITHQDPMSALKMAVSMKRL
Atome Classification :
(20 SA)
-------------------.........10..--..-....20--...------..-.-----.-.30........40...-.----....50........60......---.------.70...-.....80---......----------------...90.....-..-.100.......-----------110.....-..-.120--------------.....---.------.130....---.---...140-----.....-----..150.........160.......170-..-.---..----..180-.----------......190..-.....200.---...-...210......----.------------.220......-.----------.--.230.......240------.-----...-....250-.......260-......------..270-.......280--------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------MAK
Q
A
R
K
R
I
L
IGG--GS-EQ
P
M
R
K
--
K
M
L
------
F
I
-
P
-----
F
-
A
L
L
L
S
A
C
S
S
V
TQESDN-T----
H
L
S
S
S
I
S
E
TVTSPEKSSTKTAS---T------TE
Q
T
MA-TSNN
E
K
----
K
T
A
L
D
Q
----------------
L
K
EQQPNVPM-P
L
-
D
V
PVSS
G
Y
L
N
I
-----------
A
A
-
T
HTKQ-G
Y
-
S
I
L
Y
--------------
Y
RTDR---P------LG-L
N
A
D
E
---L---NQET
P
I
-----
A
T
Y
L
Y
-----
Q
YG--FASSQ
E
T
I
Q
V
LQ
P
F
EIDTNG
Q
Q
-
V
D-L---GS----RITGY-Q----------QGAAGSS
F
L
E
W-QEG
N
W
R
I
R
I
---RGN-NIEGQ-D
P
L
L
L
A
----
K
------------
E
I
--
V
A
Y
L
E
E-N----------S--LPA
P
E
QF
G
K
I
T
V
D-------M-----GDT-TN
R
A
V
E
V
-
S
WQEPK
N
A
Y
--
T
I
THQD------
P
M
S
A
L
-
K
M
A
V
SMKR-L--------------------------------
79
Fugue
58.62
17%
126
- C3 -
-
4DIM
-
?
A:
[3-400]
DN
K
R
L
L
I
L
G
AGRGQ
L
G
L
Y
K
A
A
K
E
L
G
I
H
T
I
A
G
T
MP
N
A
-
H
K
P
C
L
N
--
L
A
D
------
E
I
-
S
-----
Y
M
D
I
--
S
N
P
D
E
V
E
Q
K
V
K
D
-
L
----
N
L
D
G
A
A
T
C
C
L
D
T
G
I
V
S
L
A
R
I
C
D
---
K
E
N
L
V
G
L
N
E
E
A
A
I
M
C
G
D
K
Y
K
M
---
K
E
A
F
K
K
Y
NVNTARHFVVRN
E
N
E
L
K
N
A
L
E
N
L
K
L
-
P
V
-
I
V
K
A
T
D
L
I
Y
I
A
KK
E
E
E
A
I
D
G
F
N
E
T
M
N
L
T
K
R
-
D
Y
-
C
I
V
E
E
F
I
E
G
Y
E
F
G
A
Q
A
F
V
Y
K
N
D
V
---
L
------
F
V
M
P
H
G
D
E
---
T
Y
M
S
H
T
A
V
P
V
-----
G
H
Y
V
P
LDVK
D
D
I
I
--
E
K
T
K
T
E
V
K
K
A
I
K
A
L
G
L
N
N
C
A
V
N
-
V
D
M
I
---
L
K
DN
E
V
Y
I
I
E
L
-
T
----------
G
R
V
G
A
N
C
L
P
E
L
-
V
E
I
N
Y
G
I
E
Y
Y
K
M
I
A
S
M
A
I
-
S
E
-
N
P
L
V
F
W
S
Q
KS
K
------------
E
N
--
K
A
G
L
A
R
M
I
----------
I
--
E
T
E
K
S
G
I
L
K
E
I
L
N
-------
S
-----
N
A
K
-
D
D
D
I
V
E
I
-
T
F
F
K
E
E
N
D
E
--
I
K
K
F
E
N
------
S
N
D
C
I
G
Q
I
I
V
K
E
E
T
-
L
D
K
C
K
D
K
L
D
V
I
I
N
N
I
N
I
I
L
K-------------
76
Fugue
57.45
18%
40
- C3 -
-
4INO
-
?
A:
[34-335]
---------------------
Q
E
V
K
V
K
D
Y
F
G
E
--
Q
T
-
I
K
L
P
V
S
--
K
I
I
------
Y
L
-
G
SFAE-
V
-
P
A
M
F
H
T
W
D
R
V
V
G
I
S
D
Y
-
A
----
F
K
S
D
I
V
K
A
T
L
K
D
P
E
R
I
-------------------
K
P
M
-
S
S
D
H
A
A
----
A
L
N
V
E
L
----------------
L
K
K
L
S
P
--------
D
L
V
V
T
F
V
G
N
P
K
-----------
A
V
-
E
H
A
K
K
F
G
I
-
S
F
L
S
--------------
F
Q
-
E
K
---
T
------
I
A
-
E
V
M
E
D
---
I
---
D
T
Q
A
K
A
-----
L
E
V
D
A
-----
S
K
K
--
L
A
K
M
Q
E
T
L
D
F
I
A
E
R
L
K
G
V
K
K
K
K
G
V
E
-
L
F
HK
A
N
----
K
I
S
G
H
-
Q
------------
A
L
D
S
D
I
L
E
K
G
G
I
D
N
F
G
L
K
Y
---
V
K
F
-
G
R
A
D
I
-
S
V
E
K
I
V
----
K
------------
E
N
PE
I
I
F
I
W
W
-
I
----------
S
--
P
L
S
P
E
D
V
L
N
---------------------
N
P
K
F
A
T
I
-
K
A
I
K
N
K
Q
V
Y
--
K
L
P
T
M
D
IGGPR
A
P
L
I
S
L
-
F
I
A
L
K
A
H
P
-
E
AFKGVD
I
N
A
I
V
K
D
Y
Y
K
V
V
FDLNDAEVEPFLWH
77
Fugue
56.14
19%
49
- C3 -
-
3G8Q
-
CDAT8_METKA
A:
[1-278]
------------------------
M
K
V
S
L
--
A
--
G
Q
-
T
V
D
V
K
K
--
I
L
N
------
E
I
-
P
KR
T
V
T
A
-
A
L
L
E
G
G
E
I
V
A
V
E
E
A
D
D
-
E
----
H
-----------
A
E
R
K
L
V
R
R
H
D
---
V
------
E
G
K
V
V
F
-
V
T
A
R
P
C
----
L
Y
C
A
R
E
----------------
L
A
E
A
G
V
A
G
V
V
-
Y
L
-
G
R
G
R
G
L
G
P
Y
Y
L
-----------
A
-----
R
S
-
G
V
-
E
V
V
E
--------------
V
H
P
D
E
---
P
------
L
G
-
Y
D
P
V
D
RLD
V
---
L
L
T
F
G
G
-----
N
P
Y
L
T
-----
E
E
D
--
V
A
A
R
V
Y
C
L
L
T
G
R
G
F
D
A
D
I
A
P
A
P
-
E
N
-
L
---
S
G
----
R
V
E
I
M
V
T
----------
R
G
D
P
D
E
A
V
E
L
L
-
K
E
E
L
P
V
F
R
I
---
R
R
F
-
L
I
S
G
E
F
D
R
D
E
L
R
----
E
------------
R
I
--
L
E
D
I
E
P
-
R
----------
I
--
L
D
P
F
A
V
R
A
R
I
A
R
A
-------
G
-----
A
F
S
-
S
S
R
E
A
E
V
-
F
I
G
D
V
L
T
S
V
G
R
E
V
N
L
N
D
------
P
R
T
V
V
-
T
V
D
V
L
G
P
R
-
V
S
V
G
V
E
K
R-------------------------
83
Fugue
52.64
13%
-
- C- -
-
4QYX
-
HSP31_YEAST
A:
[2-236]
----------------------
A
P
K
K
V
L
L
A
L
T
--
S
Y
-
N
D
V
F
Y
S
DG
A
K
T
------
G
V
-
F
-----
V
-
V
E
A
L
H
P
F
N
T
F
R
K
E
G
F
E
-
V
----
D
F
V
S
E
T
G
K
F
--
G
W
D
E
H
S
L
A
K
D
F
---
L
------
N
G
Q
D
E
T
-
D
F
K
N
K
D
----
S
D
F
N
K
T
----------------
L
A
K
I
K
T
------------------------------
P
K
-
E
V
N
A
D
-
D
Y
-
Q
I
F
F
--------------
A
S
A
G
H
---
G
------
T
L
-
F
D
Y
P
K
---
A
---
K
D
L
Q
D
I
-----
A
S
E
I
Y
-----
A
N
G
G
V
V
A
A
V
C
H
G
P
A
I
F
D
G
L
T
D
K
K
T
G
R
P
-
L
I
-
E
---
G
K
----
S
I
T
G
F
-
T
----------
D
V
G
E
T
I
L
--------
G
V
D
S
I
L
---
K
A
K
-
N
L
A
-------
T
V
----
E
------------
D
V
--
A
K
K
Y
G
A
-
K
----------
Y
--
L
A
P
V
G
P
W
D
D
Y
S
I
T
-------
D
-----
G
-------------------
R
--
L
V
T
G
V
N
------
P
A
S
A
H
-
S
T
A
V
R
S
I
V
-
A
L
K------------------------------
78
Fugue
51.35
15%
46
- C3 -
-
4LDV
5
ARFA_ARATH
A:
[16-356]
----------------S
D
A
L
C
R
E
L
W
H
A
C
A
G
P
L
--
V
T
-
L
P
R
E
G
E
--
R
V
Y
------
Y
F
-
P
-----
E
-
G
H
M
E
Q
L
E
A
S
M
H
Q
G
L
E
Q
-
Q
M
P
S
F
N
L
P
S
K
I
L
C
K
V
I
N
I
Q
R
R
A
E
T
D
E
V
---
Y
------
A
Q
I
T
L
L
-
P
E
-----------
L
D
Q
----------------
S
E
P
T
S
P
D
A
P
V
-
Q
E
-
T
V
H
S
F
C
K
T
L
T
A
-----------
S
D
-
T
S
T
H
G
-
G
F
-
S
V
L
R
--------------
R
H
A
D
D
CLP
P
------
L
D
-
M
S
Q
Q
P
---
P
---
W
Q
E
L
V
A
T
D
LHN
S
E
W
H
F
-----
R
H
I
--
F
R
G
Q
P
R
R
H
L
L
T
T
G
W
S
V
F
V
S
S
K
K
-
L
V
-
A
---
G
D
----
A
F
I
F
L
-
R
G
ENE
E
L
R
V
G
V
R
R
H
M
P
S
S
V
I
S
S
-
H
S
M
H
I
G
V
L
A
---
T
A
A
-
H
A
I
T
T
-
G
T
I
F
S
V
----
F
Y
K
PRTSRSEFIV
S
V
--
N
R
Y
L
E
A
-
K
T
QKLSVG
M
R
F
K
--
M
R
F
K
R
F
S
G
T
I
V
G
V
QENKSSV
W
-----
H
D
S
-
E
W
R
S
L
K
V
-
Q
W
D
E
P
S
S
V
F
--
R
P
E
R
V
S
------
P
W
E
L
E
-
P
L
N
---------------------------------------
82
Fugue
48.19
18%
94
- C- -
-
4RWR
-
?
A:
[63-331]
-------------------
V
Y
R
E
K
Q
K
K
V
--
E
S
--
L
P
M
E
E
Y
V
T
G
--
V
V
A
S
E
MNAS
F
E
-
I
-----
E
-
A
L
K
A
Q
A
L
A
A
R
T
F
V
V
Q
R
M
L
----
S
G
G
K
K
N
N
A
D
V
T
D
T
D
Q
V
Y
K
S
K
E
E
---
L
------
K
K
Q
W
G
N
-
N
Y
E
N
N
L
----
K
K
I
E
E
A
----------------
V
S
K
T
A
G
Q
V
L
T
-
Y
E
-
G
K
P
I
S
A
S
F
F
S
T
-----------
S
N
-
G
R
T
E
N
-
A
A
-
D
--
Y
--------------
W
G
N
D
Y
---
P
Y-----
L
K
-
S
V
D
S
P
---
W
---
D
Q
A
S
P
K
-----
F
T
S
E
Q
-----
I
F
T
--
V
A
D
F
Q
K
R
L
G
V
----
K
V
L
A
D
G
K
V
-
G
D
-
I
---
K
G
----
R
----------------------------
T
E
G
K
--------
R
V
K
-
D
V
A
F
Q
-
G
K
T
L
T
G
----
R
------------
D
V
--
R
D
K
L
E
L
-
R
----------
S
SD
F
T
W
K
Q
E
G
D
K
I
V
V
T
-------
T
K
G
FGH
G
V
G
M
S
Q
Y
G
A
N
G
M
A
A
E
G
K
K
--------
Y
T
D
------
I
V
A
H
Y
-
Y
K
G
V
E
I
K
T
M
N
DY------------------------------
81
Fugue
45.05
16%
-63
- C1 -
-
1L2M
-
REP_TYCSV
A:
[4-121]
----------------------------------------------------------------------------------------------------
S
G
R
F
S
I
K
A
K
---
N
------
Y
F
L
T
Y
P
-
K
C
D
L
T
K
----
E
N
A
L
S
Q
----------------
I
T
N
---------
L
-
Q
T
P
T
N
K
L
F
I
K
I
-----------
C
R
-
E
L
H
E
N
-
G
-----------------------------------------------------
E
P
H
-----
L
H
I
L
I
-----
Q
F
-----
E
G
K
Y
N
C
T
N
Q
R
F
F
D
L
V
S
P
T
R
S
-
A
H
-
F
---
H
P
----
N
I
Q
G
A
-
K
----------
S
S
S
D
V
K
S
Y
I
D
--
K
D
G
D
V
-
L
E
W
---
G
T
F
-
Q
I
D
G
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
43.57
26%
109
* C2 *
-
5FQE
-
?
A:
[75-199]
-----------------------------------------------------------------------------------------------
T
N
S
S
P
V
N
N
V
T
L
S
S
S
DFI
N
------
E
N
G
D
L
I
-
S
S
N
N
I
K
I
S
W
L
K
E
T
L
A
N
----------------
I
G
R
S
N
P
S
A
P
L
E
P
F
P
D
I
I
H
N
S
G
S
L
N
I
-----------
E
K
-
N
K
I
A
S
-
A
W
I
N
I
K
I
--------------
P
R
N
A
K
---
P
G
I
Y
N
G
S
I
E
-
V
T
A
D
E
---
L
---
E
K
----------
S
Y
T
F
-----
D
Y
S
--
F
----
E
V
L
N
L
V
Q
P
L
P
S
E
T
N
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
42.81
26%
108
- C2 -
-
5FQF
2
?
A:
[75-199]
-----------------------------------------------------------------------------------------------
T
N
S
S
P
V
N
N
V
T
L
S
S
S
DFI
N
------
E
N
G
D
L
I
-
S
S
N
N
I
K
I
S
W
L
K
E
T
L
A
N
----------------
I
G
R
S
N
P
S
A
P
L
E
P
F
P
D
I
I
H
N
S
G
S
L
N
I
-----------
E
K
-
N
K
I
A
S
-
A
W
I
N
I
K
I
--------------
P
R
N
A
K
---
P
G
I
Y
N
G
S
I
E
-
V
T
A
D
E
---
L
---
E
K
----------
S
Y
T
F
-----
D
Y
S
--
F
----
E
V
L
N
L
V
Q
P
L
P
S
E
T
N
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
41.90
26%
108
- C2 -
-
5FR0
-
?
A:
[75-202]
-----------------------------------------------------------------------------------------------
T
N
S
S
P
V
N
N
V
T
L
S
S
S
D
FI
N
------
E
N
G
D
L
I
-
S
S
N
N
I
K
I
S
W
L
K
E
T
L
A
N
----------------
I
G
R
S
N
P
S
A
P
L
E
P
F
P
D
I
I
H
N
S
G
S
L
N
I
-----------
E
K
-
N
K
I
A
S
-
A
W
I
N
I
K
I
--------------
P
R
N
A
K
---
P
G
I
Y
N
G
S
I
E
-
V
T
A
D
E
---
L
---
E
K
----------
S
Y
T
F
-----
D
Y
S
--
F
----
E
V
L
N
L
V
Q
P
L
P
S
E
T
N
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
41.64
26%
110
- C2 -
-
5FQH
-
?
A:
[75-199]
-----------------------------------------------------------------------------------------------
T
N
S
S
P
V
N
N
V
T
L
S
S
S
DFI
N
------
E
N
G
D
L
I
-
S
S
N
N
I
K
I
S
W
L
K
E
T
L
A
N
----------------
I
G
R
S
N
P
S
A
P
L
E
P
F
P
D
I
I
H
N
S
G
S
L
N
I
-----------
E
K
-
N
K
I
A
S
-
A
W
I
N
I
K
I
--------------
P
R
N
A
K
---
P
G
I
Y
N
G
S
I
E
-
V
T
A
D
E
---
L
---
E
K
----------
S
Y
T
F
-----
D
Y
S
--
F
----
E
V
L
N
L
V
Q
P
L
P
S
E
T
N
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
41.64
26%
110
- C2 -
-
5FQG
1
?
A:
[75-199]
-----------------------------------------------------------------------------------------------
T
N
S
S
P
V
N
N
V
T
L
S
S
S
DFI
N
------
E
N
G
D
L
I
-
S
S
N
N
I
K
I
S
W
L
K
E
T
L
A
N
----------------
I
G
R
S
N
P
S
A
P
L
E
P
F
P
D
I
I
H
N
S
G
S
L
N
I
-----------
E
K
-
N
K
I
A
S
-
A
W
I
N
I
K
I
--------------
P
R
N
A
K
---
P
G
I
Y
N
G
S
I
E
-
V
T
A
D
E
---
L
---
E
K
----------
S
Y
T
F
-----
D
Y
S
--
F
----
E
V
L
N
L
V
Q
P
L
P
S
E
T
N
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
40.78
25%
-201
- C4 -
-
4ZHW
-
?
A:
[116-131]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
A
----
E
------------
S
V
--
A
A
V
F
R
E
-
A
----------
G
--
M
P
-----------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
38.71
29%
-48
- C4 -
-
3DX5
3
ASBF_BACAN
A:
[32-126]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
-----------
W
G
-
T
H
A
Q
N
-
L
Y
-
M
Q
E
Y
--------------
E
T
T
E
R
---
E
------
L
N
-
C
L
K
D
K
---
T
---
L
E
I
T
M
I
-----
S
D
Y
L
D
-----
I
S
L
--
S
A
D
F
E
K
T
I
E
K
C
E
Q
L
A
I
L
A
N
W
F
K
-
T
N
-
K
---
I
R
----
T
F
A
G
--
Q
----------
K
G
S
A
D
F
S
Q
Q
E
R
-
Q
E
Y
V
N
R
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Fugue
29.56
28%
87
- C3 -
-
3C9J
1
M2_I97A1
A:
[1-25]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
-
D
P
L
V
V
A
----
A
------------
S
I
--
I
A
I
L
H
L
-
I
----------
L
--
W
I
L
D
R
L
-------------------------------------------------------------------------------------------------------
80
Fugue
25.71
24%
81
* C3 *
-
4QKC
3
M2_I72A2
A:
[2-26]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
-
D
P
L
V
V
A
----
A
------------
S
I
--
I
G
I
L
H
L
-
I
----------
L
--
W
I
L
D
R
L
-------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
19.87
33%
-
- C- -
-
3ZLC
-
ERV41_YEAST
A:
[211-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
--------------
P
Y
I
D
N
---
P
------
L
D
--
N
T
A
Q
---
F
---
N
Q
D
E
P
L
-----
T
T
Y
V
Y
----------
Y
T
S
V
V
P
T
L
F
K
K
L
G
A
E
V
D
T
N
Q
Y
S
-
V
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
HHSearch
16.97
6%
-74
- C2 -
-
2NC8
-
A:
[12-26]
------------------------------------------------------
G
R
-
E
-----
N
-
L
Y
F
Q
G
H
M
L
R
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
6.60
7%
118
* C4 *
-
2AP3
-
?
A:
[3-22]
---------------------------------------------------------
M
-----
G
-
I
Q
R
P
T
S
T
T
T
D
K
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
1.99
20%
-
- C2 -
-
2K3A
-
?
A:
[1-21]
----------------------------------------
M
K
K
--
L
V
T
------
A
T
T
L
-----
T
-
A
G
I
G
A
A
I
V
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------