@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U3P5: (2017-12-25 )
MKERMYMKVKKAVIPAAGLGTRFLPATKAMAKEMLPIVDKPTIQFIVEEALKSGIEDILIVTGKAKRPIEDHFDSNIELETNLSEKGKTELLKLVEETTDVNLHFIRQSHPKGLGHAVLQARAFIGNEPFVVMLGDDIMEDEVPLTQQLIDDYERTHASTIAVMQVPHDETSKYGIINPGEVLEDGLYNVKNFVEKPDPSKAPSDLAIIGRYLLTPEIFDVLSEQQPGAGNEIQLTDAIDTLNKTQRVFARKFTGKRYDVGDKFGFMKTSIEYGLTHPEVGAPLREYILSLGKTLEAEGSKIDHNPKGITEIKEEKKK
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80..---.....-.90...-.--...--.--100........110.......120....--...130.....--..140..-......150......----.160.......170......-.180...-.-..---.190.......200.......210.......220.......230.......240-....-...250.......260.......270.......280.......290.......300.......310......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKE
R
M
Y
M
K
V
K
K
A
VIPAAGLGTRFL
P
A
T
K
A
M
A
K
E
MLPIVDK
P
T
I
Q
F
I
V
E
E
A
L
KSGIE
D
I
L
I
V
TGKAKRP
I
E
D
HFDSN
I
E
L
ETNL---SEK
G
K
-
T
E
L
L
K
L
-
V
--
E
ET--T--D-
V
N
L
H
F
I
RQSHPK
G
L
G
H
A
V
L
Q
A
R
A
F
IG--NE
P
F
V
V
M
LGDD--IMED-EV-
P
L
T
Q
Q
L
I
D
D
Y
E
R
THA----
S
T
I
A
V
M
QVPHDETSKYGII
N
-
P
G
E
V
L
E
D
-
G
-
L
Y
---
N
V
K
N
F
VEKPDPSKAPS
D
L
A
I
I
G
R
Y
LL
T
P
E
I
F
D
V
L
SEQQPGAGN
E
I
Q
L
T
D
A
I
D
T
L
-
N
K
T
Q
-
R
V
F
A
R
K
FTGKRYDVGDKFG
F
M
K
T
S
I
EYGLTHPEVGA
P
L
R
E
Y
I
L
S
LGKTLEAEGSKIDHNPK
G
I
T
E
I
K
E
E
KKK
1
PsiBlast_PDB
85.30
48%
-3
- C1 -
-
5J49
1
?
A:
[10-300]
------
L
K
V
T
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
S
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
A
A
G
I
T
E
M
I
F
V
T
G
R
S
K
R
A
I
E
D
H
F
D
K
S
Y
E
I
E
A
E
L
---
Q
A
R
G
K
-
D
K
L
L
E
L
-
V
--
R
S
I
KP
S
--
H
-
V
D
C
F
Y
V
R
Q
P
E
A
L
G
L
G
H
A
V
L
C
A
E
K
L
V
G
--
D
N
P
F
A
V
I
L
A
D
D
--
L
L
Y
G
-
T
P
-
P
V
M
A
Q
M
I
E
V
F
D
H
Y
H
S
----
S
V
I
G
V
E
E
I
P
A
Q
E
T
K
S
Y
G
I
V
D
--
G
K
E
W
E
D
-
S
-
I
I
---
K
M
S
G
I
V
E
K
P
E
P
N
V
A
P
S
N
L
G
V
V
G
R
Y
V
L
K
P
R
I
F
E
H
L
R
A
L
K
P
G
A
G
G
E
L
Q
L
T
D
A
I
Q
S
L
-
L
A
D
E
-
Q
V
L
A
Y
K
Y
H
G
T
R
F
D
C
G
S
K
L
G
Y
L
K
A
T
V
E
F
A
L
R
H
P
E
V
A
A
D
F
E
E
Y
L
R
T
R
S
P
V
L
E
----------------------
5
PsiBlast_PDB
84.08
48%
-20
- C1 -
-
3JUJ
-
?
A:
[2-268]
--------
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
E
I
E
H
Q
I
---
Q
G
T
N
K
-
E
N
A
L
K
S
-
I
--
R
N
I
--
I
--
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
V
I
L
A
D
D
L
C
I
S
H
D
-
H
P
-
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
----
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
--
G
E
W
L
E
E
-
G
-
V
Y
---
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
---------------------------------------------
21
PsiBlast_CBE
82.34
48%
1
- C1 -
-
5J49
1
?
B:
[10-300]
------
L
K
V
T
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
S
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
A
A
G
I
T
E
M
I
F
V
T
G
R
S
K
R
A
I
E
D
H
F
D
K
S
Y
E
I
E
A
E
L
---
Q
A
R
G
K
-
D
K
L
L
E
L
-
V
--
R
S
I
KP
S
--
H
-
V
D
C
F
Y
V
R
Q
P
E
A
L
G
L
G
H
A
V
L
C
A
E
K
L
V
G
--
D
N
P
F
A
V
I
L
A
D
D
--
L
L
Y
G
-
T
P
-
P
V
M
A
Q
M
I
E
V
F
D
H
Y
H
S
----
S
V
I
G
V
E
E
I
P
A
Q
E
T
K
S
Y
G
I
V
D
--
G
K
E
W
E
D
-
S
-
I
I
---
K
M
S
G
I
V
E
K
P
E
P
N
V
A
P
S
N
L
G
V
V
G
R
Y
V
L
K
P
R
I
F
E
H
L
R
A
L
K
P
G
A
G
G
E
L
Q
L
T
D
A
I
Q
S
L
-
L
A
D
E
-
Q
V
L
A
Y
K
Y
H
G
T
R
F
D
C
G
S
K
L
G
Y
L
K
A
T
V
E
F
A
L
R
H
P
E
V
A
A
D
F
E
E
Y
L
R
T
R
S
P
V
L
E
----------------------
4
PsiBlast_PDB
81.11
47%
4
- C1 -
-
5VE7
1
?
A:
[10-295]
------
L
K
V
N
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
S
P
K
E
M
L
P
V
V
D
K
P
L
I
Q
Y
A
V
E
E
A
I
A
A
G
I
T
E
M
I
F
V
T
G
R
S
K
R
A
I
E
D
H
F
D
K
S
Y
E
V
E
A
E
L
---
E
A
R
G
K
-
A
K
L
L
E
L
-
V
--
R
S
I
KP
S
--
H
-
V
D
C
F
Y
V
R
Q
P
E
A
L
G
L
G
H
A
V
L
C
A
E
K
L
V
A
--
D
N
P
F
A
V
I
L
A
D
D
--
L
L
D
G
-
N
P
-
P
V
M
K
Q
M
V
D
V
F
D
H
Y
H
S
----
S
V
I
G
V
E
E
I
P
P
S
E
T
K
S
Y
G
I
V
D
--
G
K
E
W
E
E
-
S
-
I
V
---
K
M
S
A
I
V
E
K
P
A
P
E
V
A
P
S
N
L
G
V
V
G
R
Y
I
L
K
P
R
I
F
E
H
L
R
A
L
K
P
----
E
L
Q
L
T
D
A
I
Q
A
L
-
L
A
D
E
-
Q
V
L
A
Y
K
Y
Q
G
T
R
Y
D
C
G
S
K
L
G
Y
L
K
A
T
V
E
F
A
L
R
H
P
E
V
G
T
E
F
D
A
Y
L
R
T
R
---------------------------
2
PsiBlast_PDB
81.11
47%
8
- C1 -
-
5I1F
1
?
A:
[10-294]
------
L
K
V
T
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
S
P
K
E
M
L
P
V
V
D
K
P
L
I
Q
Y
A
V
E
E
A
I
E
A
G
I
T
E
M
I
F
V
T
G
R
S
K
R
A
I
E
D
H
F
D
K
S
Y
E
I
E
A
E
L
---
E
A
R
G
K
-
E
K
L
L
S
L
-
V
--
R
S
I
KP
S
--
H
-
V
D
C
F
Y
V
R
Q
A
E
A
L
G
L
G
H
A
V
L
C
A
E
K
L
V
G
--
D
N
P
F
A
V
I
L
A
D
D
--
L
L
D
G
-
P
T
-
P
V
L
R
Q
M
I
D
V
F
D
H
Y
H
A
----
S
V
I
G
V
E
E
I
A
P
A
D
S
K
S
Y
G
V
I
D
--
G
K
R
W
E
D
-
D
-
L
F
---
K
L
S
G
I
V
E
K
P
E
P
A
Q
A
P
S
N
F
G
V
V
G
R
Y
V
L
K
P
K
I
F
K
H
L
R
G
L
K
P
G
A
G
G
E
L
Q
L
T
D
A
I
Q
S
L
-
L
T
D
E
-
Q
V
L
A
Y
R
Y
D
G
T
R
F
D
C
G
S
K
L
G
Y
L
K
A
T
V
E
F
A
L
R
H
P
E
V
A
A
D
F
E
R
Y
L
L
A
----------------------------
23
PsiBlast_CBE
80.68
48%
-28
- C1 -
-
3JUK
1
?
C:
[2-268]
--------
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
------------
N
K
-
E
N
A
L
K
S
-
I
--
R
N
I
--
I
--
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
V
I
L
A
D
D
LC
I
S
H
D
-
H
P
-
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
----
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
--
G
E
W
L
E
E
-
G
-
V
Y
---
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
---------------------------------------------
6
PsiBlast_PDB
80.07
48%
-26
- C1 -
-
3JUK
1
?
A:
[2-268]
--------
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
-----------
T
N
K
-
E
N
A
L
K
S
-
I
--
R
N
I
--
I
--
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
V
I
L
A
D
D
L
C
I
S
H
D
-
H
P
-
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
----
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
--
G
E
W
L
E
E
-
G
-
V
Y
---
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
---------------------------------------------
22
PsiBlast_CBE
79.51
48%
-22
- C1 -
-
3JUK
1
?
D:
[2-268]
--------
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
-----------
T
N
K
-
E
N
A
L
K
S
-
I
--
R
N
I
--
I
--
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
V
I
L
A
D
D
LC
I
S
H
D
-
H
P
-
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
----
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
--
G
E
W
L
E
E
-
G
-
V
Y
---
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
---------------------------------------------
3
PsiBlast_PDB
79.49
47%
4
- C1 -
-
5VCT
1
?
A:
[10-295]
------
L
K
V
N
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
S
P
K
E
M
L
P
V
V
D
K
P
L
I
Q
Y
A
V
E
E
A
I
A
A
G
I
T
E
M
I
F
V
T
G
R
S
K
R
A
I
E
D
H
F
D
K
S
Y
E
V
E
A
E
L
---
E
A
R
G
K
-
A
K
L
L
E
L
-
V
--
R
S
I
KP
S
--
H
-
V
D
C
F
Y
V
R
Q
P
E
A
L
G
L
G
H
A
V
L
C
A
E
K
L
V
A
--
D
N
P
F
A
V
I
L
A
D
D
--
L
L
D
G
-
N
P
-
P
V
M
K
Q
M
V
D
V
F
D
H
Y
H
S
----
S
V
I
G
V
E
E
I
P
P
S
E
T
K
S
Y
G
I
V
D
--
G
K
E
W
E
E
-
S
-
I
V
---
K
M
S
A
I
V
E
K
P
A
P
E
V
A
P
S
N
L
G
V
V
G
R
Y
I
L
K
P
R
I
F
E
H
L
R
A
L
K
P
----
E
L
Q
L
T
D
A
I
Q
A
L
-
L
A
D
E
-
Q
V
L
A
Y
K
Y
Q
G
T
R
Y
D
C
G
S
K
L
G
Y
L
K
A
T
V
E
F
A
L
R
H
P
E
V
G
T
E
F
D
A
Y
L
R
T
R
---------------------------
24
PsiBlast_CBE
79.48
48%
-24
- C1 -
-
3JUK
1
?
B:
[2-268]
--------
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
------------
N
K
-
E
N
A
L
K
S
-
I
--
R
N
I
--
I
--
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
V
I
L
A
D
D
L
C
I
S
H
D
-
H
P
-
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
----
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
--
G
E
W
L
E
E
-
G
-
V
Y
---
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
---------------------------------------------
28
PsiBlast_CBE
78.23
46%
-12
- C1 -
-
2UX8
1
?
E:
[14-291]
--------
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
---
A
A
R
G
K
-
S
--
L
D
V
-
L
--
D
G
T
--
R
LK
P
-
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
V
L
L
P
D
D
--
F
M
F
G
-
Q
P
-
G
C
L
K
Q
M
V
D
A
Y
N
K
V
G
G
----
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
-
P
G
T
--
Q
D
-
G
V
L
T
---
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
--------
Q
L
T
D
A
M
Q
R
M
-
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
-------------------------------
54
HHSearch
78.19
46%
5
- C1 -
-
5J49
1
?
B:
[10-298]
------
L
K
V
T
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
S
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
A
A
G
I
T
E
M
I
F
V
T
G
R
S
K
R
A
I
E
D
H
F
D
K
S
Y
E
I
E
A
E
L
---
Q
A
R
G
K
-
D
K
L
L
E
L
-
V
RS
I
K
P
--
S
--
H
-
V
D
C
F
Y
V
R
Q
P
E
A
L
G
L
G
H
A
V
L
C
A
E
K
L
V
G
--
D
N
P
F
A
V
I
L
A
D
D
--
L
L
Y
G
-
T
P
-
P
V
M
A
Q
M
I
E
V
F
D
H
Y
H
S
----
S
V
I
G
V
E
E
I
P
A
Q
E
T
K
S
Y
G
I
V
D
-
G
K
E
W
-
E
D
-
S
-
I
I
---
K
M
S
G
I
V
E
K
P
E
P
N
V
A
P
S
N
L
G
V
V
G
R
Y
V
L
K
P
R
I
F
E
H
L
R
A
L
K
P
G
A
G
G
E
L
Q
L
T
D
A
I
Q
S
L
-
L
A
D
E
-
Q
V
L
A
Y
K
Y
H
G
T
R
F
D
C
G
S
K
L
G
Y
L
K
A
T
V
E
F
A
L
R
H
P
----
E
V
A
A
D
F
E
E
Y
L
R
T
R
S
P
V
--------------------
58
HHSearch
77.69
46%
8
- C1 -
-
3JUJ
-
?
A:
[1-272]
-------
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
E
I
E
H
Q
I
QGT
N
K
E
N
A
-
L
K
S
I
R
N
-
I
----
I
--
E
--
K
-
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
V
I
L
A
D
D
--
L
C
I
S
H
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
----
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
-
G
E
W
L
-
E
E
-
G
-
V
Y
---
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
Y
K
K
R
-----------------------------------------
30
PsiBlast_CBE
77.27
46%
-12
- C1 -
-
2UX8
1
?
C:
[14-291]
--------
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
---
A
A
R
G
K
-
S
--
L
D
V
-
L
--
D
G
T
--
R
LK
P
-
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
V
L
L
P
D
D
--
F
M
F
G
-
Q
P
-
G
C
L
K
Q
M
V
D
A
Y
N
K
V
G
G
----
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
-
P
G
T
--
Q
D
-
G
V
L
T
---
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
-------
Q
L
T
D
A
M
Q
R
M
-
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
-------------------------------
49
HHSearch
76.70
45%
-22
- C1 -
-
2UX8
1
?
G:
[10-294]
----
T
I
K
P
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
---
A
A
R
G
K
S
L
D
V
L
D
--
G
--
T
R
L
--
K
--
P
-
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
V
L
L
P
D
D
--
F
M
F
G
-
Q
P
-
G
C
L
K
Q
M
V
D
A
Y
N
K
V
G
G
----
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
-
P
G
T
Q
------
D
G
VLT
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
K
G
A
G
G
E
I
Q
L
T
D
A
M
Q
R
M
-
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
A
V
K
----------------------------
26
PsiBlast_CBE
76.69
46%
-8
- C1 -
-
2UX8
1
?
G:
[14-291]
--------
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
---
A
A
R
G
K
-
S
--
L
D
V
-
L
--
D
G
T
--
R
LK
P
-
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
V
L
L
P
D
D
--
F
M
F
G
-
Q
P
-
G
C
L
K
Q
M
V
D
A
Y
N
K
V
G
G
----
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
-
P
G
T
--
Q
D
-
G
V
L
T
---
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
K
G
A
G
G
E
I
Q
L
T
D
A
M
Q
R
M
-
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
-------------------------------
27
PsiBlast_CBE
76.47
46%
-14
- C1 -
-
2UX8
1
?
F:
[14-291]
--------
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
---
A
A
R
G
K
-
S
--
L
D
V
-
L
--
D
G
T
--
R
LK
P
-
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
V
L
L
P
D
D
--
F
M
F
G
-
Q
P
-
G
C
L
K
Q
M
V
D
A
Y
N
K
V
G
G
----
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
-
P
G
T
--
Q
D
-
G
V
L
T
---
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
K
------
Q
L
T
D
A
M
Q
R
M
-
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
-------------------------------
29
PsiBlast_CBE
76.38
46%
-12
- C1 -
-
2UX8
1
?
D:
[14-291]
--------
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
---
A
A
R
G
K
-
S
--
L
D
V
-
L
--
D
G
T
--
R
LK
P
-
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
V
L
L
P
D
D
--
F
M
F
G
-
Q
P
-
G
C
L
K
Q
M
V
D
A
Y
N
K
V
G
G
----
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
-
P
G
T
--
Q
D
-
G
V
L
T
---
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
-------
Q
L
T
D
A
M
Q
R
M
-
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
-------------------------------
31
PsiBlast_CBE
75.53
46%
-11
- C1 -
-
2UX8
1
?
B:
[14-291]
--------
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
---
A
A
R
G
K
-
S
--
L
D
V
-
L
--
D
G
T
--
R
LK
P
-
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
V
L
L
P
D
D
--
F
M
F
G
-
Q
P
-
G
C
L
K
Q
M
V
D
A
Y
N
K
V
G
G
----
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
-
P
G
T
--
Q
D
-
G
V
L
T
---
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
--------
L
T
D
A
M
Q
R
M
-
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
E
P
A
V
R
A
F
-------------------------------
57
HHSearch
75.31
46%
-22
- C1 -
-
3JUK
1
?
A:
[1-272]
-------
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
------T--
N
K
E
N
A
-
L
K
S
I
R
N
-
I
----
I
--
E
--
K
-
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
V
I
L
A
D
D
--
L
C
I
S
H
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
----
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
-
G
E
W
L
-
E
E
-
G
-
V
Y
---
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
Y
K
K
R
-----------------------------------------
7
PsiBlast_PDB
72.60
39%
-10
- C1 -
-
2PA4
1
?
A:
[12-295]
--------
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
---
M
E
R
G
K
-
T
D
Q
V
E
I
-
I
--
R
R
A
--
A
--
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
-----
M
L
P
D
-
D
L
-
V
L
P
T
G
V
M
E
R
M
A
Q
V
R
A
E
FG
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
D
S
-
D
-
V
K
---
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
-
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
I
------------------------------
34
PsiBlast_CBE
72.58
39%
-11
- C1 -
-
2PA4
1
?
B:
[12-295]
--------
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
---
M
E
R
G
K
-
T
D
Q
V
E
I
-
I
--
R
R
A
--
A
--
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
-----
M
L
P
D
-
D
L
-
V
L
P
T
G
V
M
E
R
M
A
Q
V
R
A
E
FG
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
D
S
-
D
-
V
K
---
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
-
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
I
------------------------------
51
HHSearch
72.06
39%
0
- C1 -
-
2PA4
1
?
D:
[11-308]
-------
A
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
---
M
E
R
----
D
Q
V
E
I
I
R
--
R
A
A
--
D
--
L
-
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
DD
E
D
V
V
A
V
M
L
P
D
D
--
L
V
L
P
T
G
V
---
M
E
R
M
A
Q
V
R
A
E
F
G
G
----
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
-
I
E
A
D
T
K
D
S
D
-
V
K
---
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
-
I
D
E
G
H
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
I
K
Q
I
L
A
E
H
E
A
A
E
R
I
-----------------
52
HHSearch
71.99
39%
1
- C1 -
-
2PA4
1
?
B:
[10-308]
------
N
A
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
---
M
E
R
G
K
-
T
D
Q
V
E
I
I
R
--
R
A
A
--
D
--
L
-
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
DD
E
D
V
V
A
V
M
L
P
D
D
--
L
V
L
P
T
G
V
---
M
E
R
M
A
Q
V
R
A
E
F
G
G
----
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
-
I
E
A
D
T
K
D
S
D
-
V
K
---
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
-
I
D
E
G
H
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
I
K
Q
I
L
A
E
H
E
A
A
E
R
I
-----------------
32
PsiBlast_CBE
71.09
39%
-14
- C1 -
-
2PA4
1
?
D:
[12-295]
--------
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
---
M
E
R
----
D
Q
V
E
I
-
I
--
R
R
A
--
A
--
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
-----
M
L
P
D
-
D
L
-
V
L
P
T
G
V
M
E
R
M
A
Q
V
R
A
EFGG
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
D
S
-
D
-
V
K
---
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
-
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
I
------------------------------
33
PsiBlast_CBE
70.80
39%
-9
- C1 -
-
2PA4
1
?
C:
[12-295]
--------
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
---
M
E
R
G
K
-
T
D
Q
V
E
I
-
I
--
R
R
A
--
A
--
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
-----
M
L
P
D
-
D
L
-
V
L
P
T
G
V
M
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
D
S
-
D
-
V
K
---
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
-
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
I
------------------------------