@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U3V2: (2017-12-25 )
MAKKTVKDIDLKDKKVLVRVDFNVPLKDGVITDDTRIKAALPTINYVLEQGGKAILFSHLGRVKTEEDKEGKSLAPVAKRLGELLGKEVTFVPETRGEQLEEAIRNMNDGDVVVFENTRFEDIDGKKESKNDTELGKYWASLGDVFVNDAFGTAHRAHASNVGIASTGIPTVAGFLMEKEIKFIGEAVEEPKRPMIAILGGAKVSDKIGVIENLIPKADKILIGGGMTYTFYEAKGIKIGNSLVEADKVELAKELIEKAGDKLVLPIDNVCAPEFSNDVETQVIEGDIPDGLMALDIGPASVKLFADTLQGAKTVVWNGPMGVFEMSNFAKGTIGVCEAIANLEGATTIIGGGDSAAAAEQLGFADKFTHISTGGGASLELLEGKELPGLAAINDK
Atome Classification :
(59 SA)
.........10........20.......-.30.........40........50.-.-..-....60...-...----------------..70.--------------.......80........90......-..100....---...110.......120------.--------.....--.----..-130--.---------------.-----......-.140---..-.....150.......160....--...170-.-..-.-.....180.......190.......200.......210...--....220.......230-..-.-.-.-..240...-------....250.......---260-..---.......270......--.280.--...---.--.-.--..290-....----.....300.......310.......320.......330.......340-...---..-....350.......360.......370.......380.......390....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAKKTVKDIDLKD
K
K
V
L
V
R
V
D
FNVPLKD-GV-ITDDT
R
I
K
AAL
P
T
I
N
Y
V
L
E
QGG-K-
A
I
-
L
F
S
H
LGRVK-TEE----------------DKEGK--------------
S
L
A
P
V
A
K
R
L
G
E
L
LGKE
V
T
FVPETR
G
-
E
Q
L
E
E
A
I
RN---MNDG
D
V
V
V
F
ENTRF--------E--------DIDGK--K----ES-K----N---------------D-----
T
E
L
G
K
Y
-
W
A
S
L
---
G
D
-
V
F
V
NDAFGTAHRAHASNVGIAS--TG
I
P
---
T
-
V
A
-
G
-
F
L
M
E
K
E
I
K
F
I
G
E
A
V
EEPKR
P
M
I
A
I
LGGAKVS
D
K
I
G
V
I
E
N
LI--PKA
D
K
I
L
IGG
G
M
T
Y
T
F
Y
-EA-K-G-I-KI
G
N
S
L
V
E
-------
A
D
K
V
E
L
A
K
E
L
I
E
KA---G---
D
K
---
L
V
L
PIDNVCAPEFSND--VE--
T
--
Q
V
I---E--G-D--IPD---
G
L
M
A
----
L
DIGP
A
S
V
K
L
F
A
D
T
LQG
A
K
T
V
V
WNGPM
G
V
F
E
M
S
N
FAK
G
T
I
G
V
C
E
A
I
---ANL---EG-
A
T
T
I
IGGGD
S
A
A
A
A
E
QLGFADKF
T
H
ISTGGG
A
S
L
E
LLEGKELPGLAAINDK
1
PsiBlast_PDB
84.88
69%
-
- C- -
-
4DG5
-
PGK_STAAR
A:
[2-396]
-
A
K
K
I
V
S
D
L
D
L
K
G
K
T
V
L
V
R
A
D
F
N
V
P
L
K
D
-
G
E
-
I
T
N
D
N
R
I
V
Q
A
L
P
T
I
Q
Y
I
I
E
Q
G
G
-
K
-
I
V
-
L
F
S
H
L
G
K
V
K
-
E
E
S
----------------
D
K
A
K
L
--------------
T
L
R
P
V
A
E
D
L
S
K
K
L
D
K
E
V
V
F
V
P
E
T
R
G
-
E
K
L
E
A
A
I
K
D
---
L
K
E
G
D
V
L
L
V
E
N
T
R
Y
--------
E
--------
D
L
D
G
K
--
K
----
E
S
-
K
----
N
---------------
D
-----
P
E
L
G
K
Y
-
W
A
S
L
---
G
D
-
V
F
V
N
D
A
F
G
T
A
H
R
E
H
A
S
N
V
G
I
-
S
--
T
H
L
E
---
T
-
A
A
-
G
-
F
L
M
D
K
E
I
K
F
I
G
G
V
V
N
D
P
H
K
P
V
V
A
I
L
G
G
A
K
V
S
D
K
I
N
V
I
K
N
L
V
--
N
I
A
D
K
I
I
I
G
G
G
M
A
Y
T
F
L
-
K
A
-
Q
-
G
-
K
-
E
I
G
I
S
L
L
E
-------
E
D
K
I
D
F
A
K
D
L
L
E
K
H
---
G
---
D
K
---
I
V
L
P
V
D
T
K
V
A
K
E
F
S
N
D
--
A
K
--
I
--
T
V
V
---
P
--
S
-
D
S-
I
P
A
---
D
Q
E
G
----
M
D
I
G
P
N
T
V
K
L
F
A
D
E
L
E
G
A
H
T
V
V
W
N
G
P
M
G
V
F
E
F
S
N
F
A
Q
G
T
I
G
V
C
K
A
I
---
A
N
L
---
K
D
-
A
I
T
I
I
G
G
G
D
S
A
A
A
A
I
S
L
G
F
E
N
D
F
T
H
I
S
T
G
G
G
A
S
L
E
Y
L
E
G
K
E
L
P
G
I
K
A
I
N
N
K
73
HHSearch
83.51
62%
-48
- C7 -
-
1VPE
2
PGKT_THEMA
A:
[2-396]
--
K
M
T
I
R
D
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
V
-
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
-
L
L
S
H
L
G
R
P
K
-
G
E
P
----------------
S
P
-
E
F
--------------
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
P
A
V
V
G
-
D
E
V
K
K
A
V
E
E
---
L
K
E
G
E
V
L
L
L
E
N
T
R
F
--------
H
------------
P
--
G
----
E
T
-
K
----
N
---------------
D
-----
P
E
L
A
K
F
-
W
A
S
L
---
A
D
-
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
--
F
-
I
P
---
S
-
V
A
-
G
-
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
--
E
K
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
-
K
A
-
L
-
G
-
K
-
E
V
G
S
S
R
V
E
-------
E
D
K
I
D
L
A
K
E
L
V
E
K
A
---
K
E
K
G
V
E
---
I
V
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
--
V
E
--
K
--
K
V
V
---
R
ID
D
-
G
--
I
P
E
---
G
W
M
G
----
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
---
A
A
L
T
E
-
K
G
-
A
I
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
70
HHSearch
82.97
68%
-
- C- -
-
4DG5
-
PGK_STAAR
A:
[2-396]
-
A
K
K
I
V
S
D
L
D
L
K
G
K
T
V
L
V
R
A
D
F
N
V
P
L
K
D
-
G
E
-
I
T
N
D
N
R
I
V
Q
A
L
P
T
I
Q
Y
I
I
E
Q
G
G
-
K
-
I
V
-
L
F
S
H
L
G
K
V
K
-
E
E
S
D---------------
K
A
-
K
L
--------------
T
L
R
P
V
A
E
D
L
S
K
K
L
D
K
E
V
V
F
V
P
E
T
R
G
-
E
K
L
E
A
A
I
K
D
---
L
K
E
G
D
V
L
L
V
E
N
T
R
Y
--------
E
------------
D
--
L
D
GKK
E
S
-
K
----
N
---------------
D
-----
P
E
L
G
K
Y
-
W
A
S
L
---
G
D
-
V
F
V
N
D
A
F
G
T
A
H
R
E
H
A
S
N
V
G
I
S
T
--
H
-
L
E
---
T
-
A
A
-
G
-
F
L
M
D
K
E
I
K
F
I
G
G
V
V
N
D
P
H
K
P
V
V
A
I
L
G
G
A
K
V
S
D
K
I
N
V
I
K
N
L
V
--
N
I
A
D
K
I
I
I
G
G
G
M
A
Y
T
F
L
-
K
A
-
Q
-
G
-
K
-
E
I
G
I
S
L
L
E
-------
E
D
K
I
D
F
A
K
D
L
L
E
K
H
---
G
---
D
K
---
I
V
L
P
V
D
T
K
V
A
K
E
F
S
N
D
--
A
K
--
I
--
T
V
V
---
P
S-
D
-
S
--
I
P
A
---
D
Q
E
G
----
M
D
I
G
P
N
T
V
K
L
F
A
D
E
L
E
G
A
H
T
V
V
W
N
G
P
M
G
V
F
E
F
S
N
F
A
Q
G
T
I
G
V
C
K
A
I
---
A
N
L
---
K
D
-
A
I
T
I
I
G
G
G
D
S
A
A
A
A
I
S
L
G
F
E
N
D
F
T
H
I
S
T
G
G
G
A
S
L
E
Y
L
E
G
K
E
L
P
G
I
K
A
I
N
N
K
3
PsiBlast_PDB
82.58
60%
-50
- C7 -
-
1VPE
2
PGKT_THEMA
A:
[2-396]
--
K
M
T
I
R
D
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
V
-
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
-
L
L
S
H
L
G
R
P
K
-
G
E
P
----------------
S
P
E
F
---------------
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
P
A
V
V
G
-
D
E
V
K
K
A
V
E
E
---
L
K
E
G
E
V
L
L
L
E
N
T
R
F
--------
H
------------
P
--
G
----
E
T
-
K
----
N
---------------
D
-----
P
E
L
A
K
F
-
W
A
S
L
---
A
D
-
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
--
F
-
I
P
---
S
-
V
A
-
G
-
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
--
E
K
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
-
K
A
-
L
-
G
-
K
-
E
V
G
S
S
R
V
E
-------
E
D
K
I
D
L
A
K
E
L
V
E
K
A
---
K
---
E
K
G
V
E
I
V
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
--
V
E
--
K
--
K
V
V
---
R
--
I
-
D
DG
I
P
E
---
G
W
M
G
----
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
---
A
A
L
T
E
-
K
G
-
A
I
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
2
PsiBlast_PDB
81.56
68%
-12
- C7 -
-
3ZLB
5
PGK_STRP2
A:
[1-398]
M
A
K
L
T
V
K
D
V
D
L
K
G
K
K
V
L
V
R
V
D
F
N
V
P
L
K
D
-
G
V
-
I
T
N
D
N
R
I
T
A
A
L
P
T
I
K
Y
I
I
E
Q
G
G
-
R
-
A
I
-
L
F
S
H
L
G
R
V
K
-
E
E
S
----------------
D
K
A
G
K
--------------
S
L
A
P
V
A
A
D
L
A
A
K
L
G
Q
D
V
V
F
P
G
V
T
R
G
-
A
E
L
E
A
A
I
N
A
---
L
E
D
G
Q
V
L
L
V
E
N
T
R
Y
--------
E
--------
D
V
D
G
K
--
K
----
E
S
-
K
----
N
---------------
D
-----
P
E
L
G
K
Y
-
W
A
S
L
---
G
D
G
I
F
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
S
A
--
N
V
E
K
---
A
-
V
A
-
G
-
F
L
L
E
N
E
I
A
Y
I
Q
E
A
V
E
T
P
E
R
P
F
V
A
I
L
G
G
S
K
V
S
D
K
I
G
V
I
E
N
L
L
--
E
K
A
D
K
V
L
I
G
G
G
M
T
Y
T
F
Y
-
K
A
-
Q
-
G
-
I
-
E
I
G
N
S
L
V
E
-------
E
D
K
L
D
V
A
K
A
L
L
E
K
A
---
N
---
G
K
---
L
I
L
P
V
D
S
K
E
A
N
A
F
A
G
Y
--
T
E
--
V
--
R
D
T
---
E
--
G
-
E
A-
V
S
E
---
G
F
L
G
----
L
D
I
G
P
K
S
I
A
K
F
D
E
A
L
T
G
A
K
T
V
V
W
N
G
P
M
G
V
F
E
N
P
D
F
Q
A
G
T
I
G
V
M
D
A
I
---
V
K
Q
---
P
G
-
V
K
S
I
I
G
G
G
D
S
A
A
A
A
I
N
L
G
R
A
D
K
F
S
W
I
S
T
G
G
G
A
S
M
E
L
L
E
G
K
V
L
P
G
L
A
A
L
T
E
K
68
HHSearch
80.87
55%
-61
- C7 -
-
1PHP
1
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
A
-
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
-
L
A
S
H
L
G
R
P
K
-
G
K
V
----------------
V
E
-
E
L
--------------
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
E
A
V
G
-
D
E
V
K
A
A
V
D
R
---
L
N
E
G
D
V
L
L
L
E
N
V
R
F
--------
Y
------------
P
--
G
----
E
E
-
K
----
N
---------------
D
-----
P
E
L
A
K
A
-
F
A
E
L
---
A
D
-
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
--
Y
-
L
P
---
A
-
V
A
-
G
-
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
--
E
K
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
-
K
A
-
L
-
G
-
H
-
D
V
G
K
S
L
L
E
-------
E
D
K
I
E
L
A
K
S
F
M
E
K
A
---
K
E
K
G
V
R
---
F
Y
M
P
V
D
V
V
V
A
D
R
F
A
N
D
--
A
N
--
T
--
K
V
V
---
P
I-
D
-
A
--
I
P
A
---
D
W
S
A
----
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
---
A
E
A
---
L
D
-
T
Y
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
4
PsiBlast_PDB
80.55
54%
-61
- C7 -
-
1PHP
1
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
A
-
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
-
L
A
S
H
L
G
R
P
K
-
G
K
V
----------------
V
E
E
L
R
---------------
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
E
A
V
G
-
D
E
V
K
A
A
V
D
R
---
L
N
E
G
D
V
L
L
L
E
N
V
R
F
--------
Y
------------
P
--
G
----
E
E
-
K
----
N
---------------
D
-----
P
E
L
A
K
A
-
F
A
E
L
---
A
D
-
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
--
Y
-
L
P
---
A
-
V
A
-
G
-
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
--
E
K
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
-
K
A
-
L
-
G
-
H
-
D
V
G
K
S
L
L
E
-------
E
D
K
I
E
L
A
K
S
F
M
E
K
A
K
E
K
G
---
V
R
---
F
Y
M
P
V
D
V
V
V
A
D
R
F
A
N
D
--
A
N
--
T
--
K
V
V
---
P
--
I
-
D
A-
I
P
A
---
D
W
S
A
----
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
---
A
E
A
---
L
D
-
T
Y
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
69
HHSearch
79.27
68%
12
- C7 -
-
3ZLB
5
PGK_STRP2
A:
[1-398]
M
A
K
L
T
V
K
D
V
D
L
K
G
K
K
V
L
V
R
V
D
F
N
V
P
L
K
D
-
G
V
-
I
T
N
D
N
R
I
T
A
A
L
P
T
I
K
Y
I
I
E
Q
G
G
-
R
-
A
I
-
L
F
S
H
L
G
R
V
K
-
E
E
S
D---------------
K
A
-
G
K
--------------
S
L
A
P
V
A
A
D
L
A
A
K
L
G
Q
D
V
V
F
P
G
V
T
R
G
-
A
E
L
E
A
A
I
N
A
---
L
E
D
G
Q
V
L
L
V
E
N
T
R
Y
--------
E
------------
D
--
V
DGKK
E
S
-
K
----
N
---------------
D
-----
P
E
L
G
K
Y
-
W
A
S
L
---
G
D
G
I
F
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
S
A
--
N
-
V
E
K
--
A
-
V
A
-
G
-
F
L
L
E
N
E
I
A
Y
I
Q
E
A
V
E
T
P
E
R
P
F
V
A
I
L
G
G
S
K
V
S
D
K
I
G
V
I
E
N
L
L
--
E
K
A
D
K
V
L
I
G
G
G
M
T
Y
T
F
Y
-
K
A
-
Q
-
G
-
I
-
E
I
G
N
S
L
V
E
-------
E
D
K
L
D
V
A
K
A
L
L
E
K
A
---
N
---
G
K
---
L
I
L
P
V
D
S
K
E
A
N
A
F
A
G
Y
--
T
E
--
V
--
R
D
T
---
E
G-
E
-
A
--
V
S
E
---
G
F
L
G
----
L
D
I
G
P
K
S
I
A
K
F
D
E
A
L
T
G
A
K
T
V
V
W
N
G
P
M
G
V
F
E
N
P
D
F
Q
A
G
T
I
G
V
M
D
A
I
---
V
K
Q
---
P
G
-
V
K
S
I
I
G
G
G
D
S
A
A
A
A
I
N
L
G
R
A
D
K
F
S
W
I
S
T
G
G
G
A
S
M
E
L
L
E
G
K
V
L
P
G
L
A
A
L
T
E
K
71
HHSearch
75.01
49%
-15
- C7 -
-
3Q3V
4
PGK_CAMJE
B:
[7-399]
--
I
I
S
I
K
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
-
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
-
L
A
S
H
L
G
R
P
K
-
E
I
S
-----------------
S
-
K
Y
--------------
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
V
M
A
K
D
V
I
G
-
E
D
A
K
T
K
A
M
N
---
L
K
A
G
E
I
L
L
L
E
N
L
R
F
--------
E
------------
K
--
G
----
E
T
-
K
----
N
---------------
D
-----
E
N
L
A
K
E
-
L
A
S
M
---
V
Q
-
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
--
F
-
F
D
EKH
K
-
G
A
-
G
-
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
L
--
P
K
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
-
K
A
-
L
-
G
-
Y
-
D
I
G
N
S
L
L
E
-------
E
E
L
L
E
E
A
N
K
I
L
T
K
G
---
K
N
L
G
V
K
---
I
Y
L
P
V
D
V
V
A
A
P
A
C
S
Q
D
--
V
P
--
M
--
K
F
V
---
P
A-
Q
-
E
--
I
P
N
---
G
W
M
G
----
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
---
S
E
----
G
H
-
A
T
S
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
-
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
-
72
HHSearch
74.70
49%
-6
- C7 -
-
3Q3V
2
PGK_CAMJE
A:
[6-399]
-
D
I
I
S
I
K
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
-
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
-
L
A
S
H
L
G
R
P
K
-
E
I
S
-----------------
S
-
K
Y
--------------
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
V
M
A
K
D
V
I
G
-
E
D
A
K
T
K
A
M
N
---
L
K
A
G
E
I
L
L
L
E
N
L
R
F
--------
E
------------
K
--
G
----
E
T
-
K
----
N
---------------
D
-----
E
N
L
A
K
E
-
L
A
S
M
---
V
Q
-
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
--
F
-
F
D
EKH
K
-
G
A
-
G
-
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
L
--
P
K
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
-
K
A
-
L
-
G
-
Y
-
D
I
G
N
S
L
L
E
-------
E
E
L
L
E
E
A
N
K
I
L
T
K
G
---
K
N
L
G
V
K
---
I
Y
L
P
V
D
V
V
A
A
P
A
C
S
Q
D
--
V
P
--
M
--
K
F
V
---
P
A-
Q
-
E
--
I
P
N
---
G
W
M
G
----
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
---
S
E
----
G
H
-
A
T
S
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
-
81
HHSearch
74.08
50%
-4
- C7 -
-
16PK
2
PGKC_TRYBB
A:
[2-415]
--
K
K
S
I
N
E
C
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
N
-
G
K
-
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
-
E
G
G
S
-
C
V
-
L
M
S
H
L
G
R
P
K
-
G
I
P
MAQ
A
G
K
I
R
S
T
GGVPGF
Q
Q
-
K
A
--------------
T
L
K
P
V
A
K
R
L
S
E
L
L
L
R
P
V
T
F
A
P
D
C
L
N
---
A
A
D
V
V
S
K
---
M
S
P
G
D
V
V
L
L
E
N
V
R
F
--------
Y
------------
K
--
E
----
E
G
S
K
----
K
A
K
D
------------
R
-----
E
A
M
A
K
I
-
L
A
S
Y
---
G
D
-
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
--
I
-
L
G
N
--
G
-
A
A
-
G
-
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
L
--
Q
R
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
-
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
K
C
E
-------
E
S
K
L
E
F
A
R
S
L
L
K
K
A
---
E
D
R
K
V
Q
---
V
I
L
P
I
D
H
V
C
H
T
E
F
K
A
V
--
D
S
--
P
--
L
I
T
---
E
D-
Q
-
N
--
I
P
E
---
G
H
M
A
----
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
I
A
K
A
M
---
G
R
G
T
H
E
H
G
-
L
M
S
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
D
D
K
79
HHSearch
73.83
51%
17
- C7 -
-
1QPG
2
PGK_YEAST
A:
[4-414]
-
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
-
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
-
L
A
S
H
L
G
Q
P
N
-
G
E
R
----------------
N
E
-
K
Y
--------------
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
G
-
P
E
V
E
A
A
V
K
A
---
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--------
H
------------
I
--
E
----
E
E
-
G
S
R
K
V
D
GQKVKAS
K
E
D
-----
V
-----
Q
K
F
R
H
E
-
L
S
S
L
---
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
-----
L
P
Q--
R
-
A
A
-
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
-
K
V
-
L
-
E
-
N
T
E
I
G
D
S
I
F
D
-------
K
A
G
A
E
I
V
P
K
L
M
E
K
A
---
K
A
K
G
V
E
---
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
D
--
A
N
--
T
--
K
T
V
---
T
DK
E
-
G
--
I
P
A
---
G
W
Q
G
----
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
---
V
K
S
S
A
-
A
G
-
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
7
PsiBlast_PDB
73.76
51%
-22
- C7 -
-
1V6S
2
PGK_THET8
A:
[2-385]
---
R
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
-
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
-
L
L
S
H
L
G
R
P
K
-
G
P
D
----------------
P
K
--
Y
--------------
S
L
A
P
V
G
E
A
L
R
A
H
L
-
P
E
A
R
F
A
P
F
P
P
G
-
S
--
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
------------
P
--
G
----
E
E
-
K
----
N
---------------
D
-----
P
E
L
S
A
R
-
Y
A
R
L
---
G
E
-
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
--
L
-
L
P
---
A
-
Y
A
-
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
--
P
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
-
K
A
-
L
-
G
-
G
-
E
V
G
R
S
L
V
E
-------
E
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
L
G
---
V
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
--
V
E
--
T
--
R
V
F
---
P
--
A
-
R
A-
I
P
V
---
P
Y
M
G
----
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
---
A
A
L
---
E
G
-
A
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
------
43
PsiBlast_CBE
73.67
47%
-60
- C7 -
-
4FEY
1
PGK_FRATT
A:
[4-392]
M
S
F
L
T
L
K
D
V
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
D
-
G
K
-
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
-
L
M
S
H
L
G
R
P
T
-
E
G
E
----------------
Y
D
S
Q
F
--------------
S
L
E
P
V
A
K
A
L
S
E
I
I
N
K
P
V
K
F
A
K
D
-----
W
L
D
G
V
--
D
---
V
K
A
G
E
I
V
M
C
E
N
V
R
F
--------
N
--------
S
--
G
E
--
K
----
K
S
-
T
----
D
---------------
D
-------
L
S
K
K
-
I
A
S
L
---
G
D
-
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
--
Y
I
P
V
---
A
-
C
A
-
G
-
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
L
--
D
K
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
-
K
A
-
E
-
G
-
F
-
D
V
G
N
S
L
Y
E
-------
Q
D
L
V
A
E
A
T
E
I
L
A
K
A
K
A
L
G
---
V
N
---
I
P
V
P
V
D
V
R
V
A
K
E
F
S
E
N
--
A
Q
--
A
--
I
I
K
---
K
V-
S
-
D
--
V
V
A
---
D
E
M
I
----
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
L
S
L
A
I
---
A
Q
----
S
H
-
A
F
S
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
24
PsiBlast_CBE
73.65
51%
-20
- C7 -
-
1V6S
2
PGK_THET8
B:
[2-385]
---
R
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
-
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
-
L
L
S
H
L
G
R
P
K
-
G
P
D
----------------
P
K
--
Y
--------------
S
L
A
P
V
G
E
A
L
R
A
H
L
-
P
E
A
R
F
A
P
F
P
P
G
-
S
--
E
E
A
R
R
E
AEA
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
------------
P
--
G
----
E
E
-
K
----
N
---------------
D
-----
P
E
L
S
A
R
-
Y
A
R
L
---
G
E
-
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
--
L
-
L
P
---
A
-
Y
A
-
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
--
P
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
-
K
A
-
L
-
G
-
G
-
E
V
G
R
S
L
V
E
-------
E
D
R
L
D
L
A
K
D
L
L
G
R
A
EAL
G
---
V
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
--
V
E
--
T
--
R
V
F
---
P
--
A
-
R
A-
I
P
V
---
P
Y
M
G
----
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
---
A
A
L
---
E
G
-
A
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
------
15
PsiBlast_PDB
73.59
48%
3
- C7 -
-
3Q3V
2
PGK_CAMJE
A:
[9-399]
----
S
I
K
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
-
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
-
L
A
S
H
L
G
R
P
K
-
E
I
S
----------------
S
K
Y
----------------
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
V
M
A
K
D
V
I
G
-
E
D
A
K
T
K
A
M
N
---
L
K
A
G
E
I
L
L
L
E
N
L
R
F
--------
E
------------
K
--
G
----
E
T
-
K
----
N
---------------
D
-----
E
N
L
A
K
E
-
L
A
S
M
---
V
Q
-
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
F
D
E
K
H
---
K
-
G
A
-
G
-
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
L
--
P
K
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
-
K
A
-
L
-
G
-
Y
-
D
I
G
N
S
L
L
E
-------
E
E
L
L
E
E
A
N
K
I
L
T
K
G
K
N
L
G
---
V
K
---
I
Y
L
P
V
D
V
V
A
A
P
A
C
S
Q
D
--
V
P
--
M
--
K
F
V
---
P
--
A
Q
E
--
I
P
N
---
G
W
M
G
----
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
---
S
-----
E
G
H
A
T
S
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
-
9
PsiBlast_PDB
73.34
49%
15
- C7 -
-
1QPG
2
PGK_YEAST
A:
[4-414]
-
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
-
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
-
L
A
S
H
L
G
Q
P
N
-
G
E
R
----------------
N
-
E
K
Y
--------------
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
G
-
P
E
V
E
A
A
V
K
A
---
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--------
H
IEEEG
S
R
-
K
V
D
G
Q
KV
K
----
A
S
-
K
----
E
---------------
D
-----
V
Q
K
F
R
H
E
L
S
S
L
---
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
-----
D
L
P
---
Q
R
A
A
-
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
-
K
V
L
E
-
N
-
T
-
E
I
G
D
S
I
F
D
-------
K
A
G
A
E
I
V
P
K
L
M
E
K
A
K
A
K
G
---
V
E
---
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
D
--
A
N
--
T
--
K
T
V
T
DK
E
--
G
----
I
P
A
---
G
W
Q
G
----
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
-
S
S
A
---
A
G
-
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
8
PsiBlast_PDB
72.51
50%
-24
- C7 -
-
2IE8
-
?
A:
[3-385]
----
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
-
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
-
L
L
S
H
L
G
R
P
K
-
G
P
D
----------------
P
R
--
Y
--------------
S
L
A
P
V
G
E
A
L
R
A
H
L
-
P
E
A
R
F
A
P
F
P
P
G
-
S
--
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
------------
P
--
G
----
E
E
-
K
----
N
---------------
D
-----
P
E
L
S
A
R
-
Y
A
R
L
---
G
E
-
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
--
L
-
L
P
---
A
-
Y
A
-
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
--
P
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
-
K
A
-
L
-
G
-
G
-
E
V
G
R
S
L
V
E
-------
E
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
L
G
---
V
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
--
V
E
--
T
--
R
V
F
---
P
--
A
-
R
A-
I
P
V
---
P
Y
M
G
----
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
---
A
A
L
---
E
G
-
A
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
------
74
HHSearch
72.21
51%
18
- C7 -
-
1V6S
2
PGK_THET8
A:
[2-390]
---
R
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
-
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
-
G
G
A
S
-
L
V
-
L
L
S
H
L
G
R
P
K
-
G
P
D
-----------------
P
-
K
Y
--------------
S
L
A
P
V
G
E
A
L
R
A
H
L
P
E
-
A
R
F
A
P
F
P
P
G
S
E
E
A
R
R
E
A
E
A
---
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
------------
P
--
G
----
E
E
-
K
----
N
---------------
D
-----
P
E
L
S
A
R
-
Y
A
R
L
---
G
E
-
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
--
L
-
L
P
---
A
-
Y
A
-
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
--
P
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
-
K
A
-
L
-
G
-
G
-
E
V
G
R
S
L
V
E
-------
E
D
R
L
D
L
A
K
D
L
L
G
R
A
---
E
A
L
G
V
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
--
V
E
--
T
--
R
V
F
---
P
A-
R
-
A
--
I
P
V
---
P
Y
M
G
----
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
---
A
A
L
---
E
G
-
A
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
G
-
44
PsiBlast_CBE
72.19
44%
15
- C7 -
-
4O33
2
PGK1_HUMAN
A:
[6-416]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
T
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
36
PsiBlast_CBE
71.94
44%
11
- C7 -
-
2XE6
1
PGK1_HUMAN
A:
[6-416]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
12
PsiBlast_PDB
71.63
46%
11
- C7 -
-
2P9T
1
PGK2_MOUSE
A:
[4-415]
-
A
K
L
T
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
I
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
V
G
-
P
E
V
E
Q
A
C
A
N
---
P
D
N
G
S
I
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
S
S
G
K
--
K
----
I
S
-
A
----
D
---------------
P
-----
A
K
V
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
S
G
-
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
-
K
-
N
-
M
-
Q
I
G
A
S
L
F
D
-------
E
E
G
A
T
I
V
K
E
I
M
E
K
A
E
K
N
G
---
V
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
V
G
--
Q
--
A
T
I
---
E
--
S
-
G
--
I
P
S
---
G
W
M
G
----
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
N
G
-
C
V
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
-
6
PsiBlast_PDB
71.59
47%
13
- C7 -
-
16PK
2
PGKC_TRYBB
A:
[2-415]
--
K
K
S
I
N
E
C
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
N
-
G
K
-
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
E
G
G
-
S
-
C
V
-
L
M
S
H
L
G
R
P
K
G
I
P
M
----------------
A
Q
A
G
K
I
R
S
T
GGVPGFQQKA
T
L
K
P
V
A
K
R
L
S
E
L
L
L
R
P
V
T
F
A
P
D
C
L
---
N
A
A
D
V
V
S
K
---
M
S
P
G
D
V
V
L
L
E
N
V
R
F
--------
Y
--------
K
E
E
G
S
--
K
----
K
A
-
K
----
D
---------------
R
-----
E
A
M
A
K
I
-
L
A
S
Y
---
G
D
-
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
--
I
L
G
N
---
G
-
A
A
-
G
-
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
L
--
Q
R
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
-
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
K
C
E
-------
E
S
K
L
E
F
A
R
S
L
L
K
K
A
---
E
---
D
R
K
V
Q
V
I
L
P
I
D
H
V
C
H
T
E
F
-
K
A
--
V
D
--
S
--
P
L
I
---
T
--
E
-
D
QN
I
P
E
---
G
H
M
A
----
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
I
A
K
A
M
G
R
G
T
H
E
---
H
G
-
L
M
S
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
D
D
K
51
PsiBlast_CBE
71.52
42%
4
- C7 -
-
1HDI
2
PGK1_PIG
A:
[2-412]
--
K
L
T
L
D
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
A
A
-
A
Q
-
I
T
N
N
A
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
S
P
----------------
M
P
D
K
Y
--------------
S
L
Q
P
V
A
A
E
L
K
S
A
L
G
K
A
V
L
F
L
K
D
C
V
G
-
P
A
V
E
K
A
C
A
D
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
N
--
K
----
A
A
-
G
----
E
---------------
P
-----
A
K
I
K
A
F
-
R
A
S
L
S
A
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
K
-
K
A
-
G
A
F
L
M
K
K
E
L
N
Y
F
A
A
A
A
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
A
G
K
K
I
V
K
N
L
M
S
K
A
A
A
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
Q
--
A
K
I
G
Q
--
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
K
S
S
A
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
N
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
16
PsiBlast_PDB
71.10
44%
15
- C7 -
-
2ZGV
1
PGK1_HUMAN
A:
[9-419]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
13
PsiBlast_PDB
71.06
46%
10
- C7 -
-
2PAA
1
PGK2_MOUSE
A:
[4-415]
-
A
K
L
T
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
I
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
V
G
-
P
E
V
E
Q
A
C
A
N
---
P
D
N
G
S
I
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
S
S
G
K
--
K
----
I
S
-
A
----
D
---------------
P
-----
A
K
V
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
S
G
-
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
-
K
-
N
-
M
-
Q
I
G
A
S
L
F
D
-------
E
E
G
A
T
I
V
K
E
I
M
E
K
A
E
K
N
G
---
V
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
V
G
--
Q
--
A
T
I
---
E
--
S
-
G
--
I
P
S
---
G
W
M
G
----
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
N
G
-
C
V
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
-
49
PsiBlast_CBE
70.96
44%
22
- C7 -
-
4O3F
2
PGK1_MOUSE
A:
[6-416]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
A
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
N
A
C
A
N
---
P
A
A
G
T
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
D
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
Y
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
T
E
S
S
K
K
Y
A
E
A
V
G
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
S
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
--------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
58
PsiBlast_CBE
70.87
37%
-38
- C7 -
-
2CUN
4
PGK_PYRHO
A:
[4-399]
-----
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
-
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
-
I
G
T
H
Q
G
K
P
Y
-
S
E
D
----------------
Y
T
T
T
E
--------------
E
H
A
R
V
---
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
F
G
-
R
Y
A
R
E
K
I
K
E
---
L
K
S
G
E
V
A
I
L
E
N
L
R
F
SA------
E
--------
E
V
K
N
K
--
P
I
---
E
E
-
C
----
E
---------------
K
-----
T
F
L
V
K
K
-
L
S
K
V
---
I
D
-
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
--
I
K
-
P
---
M
-
I
M
-
G
-
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
R
R
E
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
-
L
A
-
K
-
G
-
F
-
D
L
G
R
K
N
V
E
F
M
K
K
K
GL
L
D
Y
V
K
H
A
E
E
I
L
D
E
F
---
Y
---
P
Y
---
I
R
T
P
V
D
------
F
A
V
D
--
Y
K
--
G
--
E
R
V
---
E
--
I
-
D
--
L
L
S
ENR
G
L
L
H
Q
Y
QI
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
---
A
D
----
S
P
-
A
F
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
T
G
-
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
--
34
PsiBlast_CBE
70.78
44%
13
- C7 -
-
2XE8
2
PGK1_HUMAN
A:
[6-416]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
47
PsiBlast_CBE
70.56
44%
10
- C7 -
-
1VJD
1
PGK1_PIG
A:
[5-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
I
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
D
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
S
--
K
----
V
K
-
A
----
D
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
K
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
S
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
17
PsiBlast_PDB
70.39
44%
10
- C7 -
-
3C39
1
PGK1_HUMAN
A:
[9-419]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
---------------------
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
20
PsiBlast_PDB
70.30
44%
11
- C7 -
-
3C3C
2
PGK1_HUMAN
A:
[9-419]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
28
PsiBlast_CBE
70.28
44%
12
- C7 -
-
3C3B
1
PGK1_HUMAN
B:
[9-419]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-----
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
42
PsiBlast_CBE
70.10
44%
12
- C7 -
-
2Y3I
2
PGK1_HUMAN
A:
[6-416]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
50
PsiBlast_CBE
70.02
44%
10
- C7 -
-
1KF0
2
PGK1_PIG
A:
[5-415]
--
K
L
T
L
D
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
S
P
----------------
M
P
D
K
Y
--------------
S
L
Q
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
D
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
K
T
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
K
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
N
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
H
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
57
PsiBlast_CBE
69.95
37%
-37
- C7 -
-
2CUN
4
PGK_PYRHO
B:
[4-399]
-----
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
-
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
-
I
G
T
H
Q
G
K
P
Y
-
S
E
D
----------------
Y
T
T
T
E
--------------
E
H
A
R
V
---
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
F
G
-
R
Y
A
R
E
K
I
K
E
---
L
K
S
G
E
V
A
I
L
E
N
L
R
F
SA------
E
--------
E
V
K
N
K
--
P
I---
E
E
-
C
----
E
---------------
K
-----
T
F
L
V
K
K
-
L
S
K
V
---
I
D
-
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
--
I
K
-
P
---
M
-
I
M
-
G
-
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
RR
E
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
-
L
A
-
K
-
G
-
F
-
D
L
G
R
K
N
V
E
FMKKKGL
L
D
Y
V
K
H
A
E
E
I
L
D
E
F
---
Y
---
P
Y
---
I
R
T
P
V
D
------
F
A
V
D
--
Y
K
--
G
--
E
R
V
---
E
--
I
-
D
--
L
L
S
ENR
G
L
L
H
QYQI
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
---
A
D
----
S
P
-
A
F
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
T
G
-
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
--
18
PsiBlast_PDB
69.74
44%
8
- C7 -
-
3C3A
1
PGK1_HUMAN
A:
[9-419]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
---------
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
48
PsiBlast_CBE
69.62
44%
15
- C7 -
-
1VJC
1
PGK1_PIG
A:
[5-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
I
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
D
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
S
--
K
----
V
K
-
A
----
D
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
K
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
S
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
35
PsiBlast_CBE
69.50
44%
18
- C7 -
-
2XE7
2
PGK1_HUMAN
A:
[6-416]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
33
PsiBlast_CBE
69.36
44%
14
- C7 -
-
2YBE
2
PGK1_HUMAN
A:
[6-416]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
---------------
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
27
PsiBlast_CBE
69.30
44%
12
- C7 -
-
3C3C
1
PGK1_HUMAN
B:
[9-419]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-----
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
37
PsiBlast_CBE
69.27
44%
14
- C7 -
-
2X15
2
PGK1_HUMAN
A:
[5-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
---------------------
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
30
PsiBlast_CBE
69.23
44%
12
- C7 -
-
3C39
1
PGK1_HUMAN
B:
[9-419]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-------
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
41
PsiBlast_CBE
69.22
44%
13
- C7 -
-
2Y3I
2
PGK1_HUMAN
D:
[6-416]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
SKL
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
EKN
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
GQ
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
VK-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
29
PsiBlast_CBE
69.18
44%
7
- C7 -
-
3C3A
2
PGK1_HUMAN
B:
[9-419]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
------
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
--
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
25
PsiBlast_CBE
69.15
46%
16
- C7 -
-
2PAA
1
PGK2_MOUSE
B:
[4-415]
-
A
K
L
T
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
I
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
V
G
-
P
E
V
E
Q
A
C
A
N
---
P
D
N
G
S
I
I
L
L
E
N
L
R
F
--------
H
VEEEGKGK
D
S
S
G
K
--
K
----
I
S
-
A
----
D
---------------
P
-----
A
K
V
E
A
F
-
R
A
S
L
SKL
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
S
G
-
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
-
K
-
N
-
M
-
Q
I
G
A
S
L
F
D
-------
E
E
G
A
T
I
V
K
E
I
M
E
K
A
EKN
G
---
V
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
AK
V
G
--
Q
--
A
T
I
---
E
--
S
-
G
--
I
P
S
---
G
W
M
G
----
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
VK-
A
T
S
---
N
G
-
C
V
T
I
I
G
---------------
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
-
31
PsiBlast_CBE
69.10
44%
10
- C7 -
-
4AXX
2
PGK1_HUMAN
A:
[6-416]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
-----------------------
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
39
PsiBlast_CBE
69.01
44%
7
- C7 -
-
2WZC
2
PGK1_HUMAN
A:
[5-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG-----------------------------
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
40
PsiBlast_CBE
68.96
44%
5
- C7 -
-
2WZB
3
PGK1_HUMAN
A:
[5-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG-----------------------------
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
38
PsiBlast_CBE
68.96
44%
14
- C7 -
-
2X13
2
PGK1_HUMAN
A:
[5-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
---------------------
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
78
HHSearch
68.84
47%
23
- C7 -
-
2WZB
3
PGK1_HUMAN
A:
[5-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
-
L
M
S
H
L
G
R
P
D
-
G
V
P
M---------------
P
D
-
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
------------
V
--
E
----
E
E
G
K
G--------------------E
P
A
K
I
E
A
F
R
A
S
-
L
S
K
L
---
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
-----
L
P
Q
--
K
-
A
G
-
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
-
L
N
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
---
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
--
G
Q
A
---
T
VA
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
-
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
32
PsiBlast_CBE
68.73
44%
9
- C7 -
-
3ZOZ
3
PGK1_HUMAN
A:
[6-416]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG-----------------------------
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
45
PsiBlast_CBE
68.57
44%
7
- C7 -
-
2X14
2
PGK1_HUMAN
A:
[5-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG-----------------------------
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
46
PsiBlast_CBE
68.38
44%
8
- C7 -
-
2WZD
3
PGK1_HUMAN
A:
[6-416]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
-
G
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEGKG---------------------
E
---------------
P
-----
A
K
I
E
A
F
-
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-----
N
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
---
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
G
Q
A
T
V
---
A
--
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
-
A
T
S
---
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
77
HHSearch
68.34
46%
29
* C7 *
-
1VJC
1
PGK1_PIG
A:
[5-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
-
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
-
L
M
S
H
L
G
R
P
D
-
G
I
P
M---------------
P
D
-
K
Y
--------------
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
D
---
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
------------
V
--
E
----
E
E
-
G
----
K
G
K
D
ASG
S
K
V
K
A
D
P
A
K
I
-----
E
A
F
R
A
S
-
L
S
K
L
---
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
-----
L
P
K
--
K
-
A
G
-
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
-
K
V
-
L
N
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
E
G
S
K
I
V
K
D
L
M
S
K
A
---
E
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
--
A
K
--
T
--
G
Q
A
---
T
VA
S
-
G
--
I
P
A
---
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
-
R
G
-
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
75
HHSearch
68.26
49%
15
- C7 -
-
4FEY
1
PGK_FRATT
A:
[4-392]
M
S
F
L
T
L
K
D
V
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
D
-
G
K
-
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
-
L
M
S
H
L
G
R
P
T
-
E
G
E
Y---------------
D
S
-
Q
F
--------------
S
L
E
P
V
A
K
A
L
S
E
I
I
N
K
P
V
K
F
A
K
D
W
L
D
-
G
------
V
D
---
V
K
A
G
E
I
V
M
C
E
N
V
R
F
--------
N
------------
S
--
G
----
E
K
-
K
----
S
---------------
T
-----
D
D
L
S
K
K
-
I
A
S
L
---
G
D
-
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
--
Y
-
I
P
V
--
A
-
C
A
-
G
-
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
L
--
D
K
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
-
K
A
-
E
-
G
-
F
-
D
V
G
N
S
L
Y
E
-------
Q
D
L
V
A
E
A
T
E
I
L
A
K
A
---
K
A
L
G
V
N
---
I
P
V
P
V
D
V
R
V
A
K
E
F
S
E
N
--
A
Q
--
A
--
I
I
K
---
K
V-
S
-
D
--
V
V
A
---
D
E
M
I
----
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
L
S
L
A
I
---
A
Q
----
S
H
-
A
F
S
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
80
HHSearch
67.59
50%
11
- C7 -
-
3PGK
2
PGK_YEAST
A:
[5-415]
-
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
-
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
-
L
A
S
H
L
G
R
P
N
-
G
E
R
----------------
N
E
-
K
Y
--------------
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
G
-
P
E
V
E
A
A
V
K
A
---
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--------
H
------------
I
--
E
----
E
E
-
G
SRKV
D
G
Q
K
V
K
A
SK
E
D
-----
V
-----
Q
K
F
R
H
E
-
L
S
S
L
---
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
-----
L
P
Q
--
R
-
A
A
-
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
-
K
V
-
L
-
E
N
T
-
E
I
G
D
S
I
F
D
-------
K
A
V
G
P
E
I
A
K
L
M
E
K
A
---
K
A
K
G
V
E
---
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
S
--
A
N
--
T
--
K
T
V
---
T
DK
E
-
G
--
I
P
A
---
G
W
Q
G
----
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
T
V
I
L
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
---
V
K
S
SA-
A
G
-
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
10
PsiBlast_PDB
66.06
49%
5
- C7 -
-
3PGK
2
PGK_YEAST
A:
[5-415]
-
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
-
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
-
L
A
S
H
L
G
R
P
N
-
G
E
R
----------------
N
-
E
K
Y
--------------
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
G
-
P
E
V
E
A
A
V
K
A
---
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--------
H
IEEEGSR-
K
V
D
G
Q
--
K
V
K
--
A
S
-
K
----
E
---------------
D
-----
V
Q
K
F
R
H
E
L
S
S
L
---
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
-----
D
L
P
---
Q
R
A
A
-
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
-
K
V
L
E
-
N
-
T
-
E
I
G
D
S
I
F
D
K
------
A
V
G
P
E
I
A
K
-
L
M
E
K
A
K
A
K
G
---
V
E
---
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
S
--
A
N
--
T
--
K
T
V
T
DK
E
--
G
----
I
P
A
---
G
W
Q
G
----
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
T
V
I
L
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
-
S
S
A
---
A
G
-
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
53
PsiBlast_CBE
62.96
49%
5
- C7 -
-
1FW8
4
PGK_YEAST
A:
[4-343]
------------------------------------------------------------------------------------------------------------
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
G
-
P
E
V
E
A
A
V
K
A
---
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--------
H
IEEEG
S
R
-
K
V
D
G
Q
--
K
V
K
--
A
S
-
K
----
E
---------------
D
-----
V
Q
K
F
R
H
E
L
S
S
L
---
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
-----
D
L
P
---
Q
R
A
A
-
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
-
K
V
L
E
-
N
-
T
-
E
I
G
D
S
I
F
D
-------
K
A
G
A
E
I
V
P
K
L
M
E
K
A
K
A
K
G
---
V
E
---
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
D
--
A
N
--
T
--
K
T
V
T
DK
E
--
G
----
I
P
A
---
G
W
Q
G
----
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
-
S
S
A
---
A
G
-
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K