@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U3V3: (2017-12-25 )
MTVKVGINGFGRIGRLAFRRIQDVDGIEVVAINDLTDAKMLAHLLKYDTTQGRFNGTVEVHEGSFNVNGKEVKVLANRNPEELPWGELGVDIVLECTGFFTSKSAAEKHLTAGAKRVVISAPGGNDVPTIVYNTNHETLTGKETVISGASCTTNCLAPMAKTLNDKFGVVEGLMTTIHAYTGDQMTLDGPHPKGDFRRARAAAANIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPTGSLTELVTVLEKEVTVDEINAAMKEASNESYGYNTDEIVSSDIVGMTYGSLFDATQTKVMTVGDKQLVKTVAWYDNEMSYTAQLVRTLEYFANL
Atome Classification :
(25 SA)
.........10........20.....--...30........40........50........60........70........80........90........100.......110.......120.......130.......140..-......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.-.......260....-----------.-----------..270--.........280.......290.......300.......310.......320.......330.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
V
K
V
GINGF
G
R
I
G
R
L
A
F
R
R
IQDVD
G
--
I
E
V
V
A
INDL
T
D
A
K
M
L
A
H
L
L
KYDTTQGRFN
G
T
V
E
V
HEGSFNVNG
K
E
V
K
V
L
ANRNPEELPWGEL
G
V
D
I
V
L
E
CTGFFTS
K
S
A
A
E
K
H
LTAGA
K
R
V
V
I
SAPGGNDV
P
T
I
V
YNTNHETLTG-KE-
T
V
ISGASC
T
T
N
C
L
A
P
M
A
K
TLND
K
F
G
V
V
E
G
L
M
T
T
I
H
AYTGD
Q
M
TLDGPHPK
G
D
F
R
R
A
R
A
AAANIVPNSTGA
A
K
A
I
G
L
V
IPELNGKLDGAAQRVPVPT
G
S
L
T
E
L
V
T
V
L
E
K-E-V
T
V
D
E
I
N
A
A
M
K
EAS-----------N-----------ESY----GY
N
T
D
E
I
V
SSDI
V
G
M
T
Y
G
S
LFDATQ
T
K
V
M
TVG
D
K
Q
L
V
K
T
V
A
W
YDN
E
M
S
Y
T
A
Q
L
V
R
T
L
E
Y
F
ANL
113
HHSearch
94.55
80%
-76
- C4 -
-
5M6D
1
?
A:
[21-353]
G
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
--
V
E
V
T
R
I
N
D
L
T
D
P
V
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
K
F
I
K
V
S
A
E
R
D
P
E
Q
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
K
K
E
A
A
E
K
H
L
K
G
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
V
L
D
G
-
T
E
-
T
V
I
S
G
A
S
-
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
T
P
T
G
S
V
T
E
L
V
A
V
L
E
K
-
N
-
V
T
V
D
E
V
N
A
A
M
K
A
A
S
-----------
N
-----------
E
S
Y
----
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
M
S
Y
G
S
L
F
D
A
T
Q
T
K
V
L
D
V
D
G
K
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
E
Y
F
A
K
I
25
PsiBlast_CBE
94.15
77%
-85
- C4 -
-
5VMT
2
?
D:
[9-339]
M
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
E
K
A
H
G
--
I
E
V
A
A
V
N
D
L
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
N
P
E
E
L
P
W
G
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
R
A
G
A
R
K
V
V
I
S
A
P
G
G
N
D
V
K
T
V
V
Y
G
V
N
Q
D
I
L
D
G
-
S
E
-
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
V
S
V
L
E
R
-
P
-
A
T
K
E
E
I
N
A
A
M
K
A
A
S
-----------
S
-----------
E
S
Y
----
G
Y
N
E
D
Q
I
V
S
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
--
1
PsiBlast_PDB
94.01
80%
-76
- C4 -
-
5M6D
1
?
A:
[23-353]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
--
V
E
V
T
R
I
N
D
L
T
D
P
V
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
K
F
I
K
V
S
A
E
R
D
P
E
Q
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
K
K
E
A
A
E
K
H
L
K
G
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
V
L
D
G
-
T
E
-
T
V
I
S
G
A
S
-
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
T
P
T
G
S
V
T
E
L
V
A
V
L
E
K
-
N
-
V
T
V
D
E
V
N
A
A
M
K
A
A
S
-----------
N
-----------
E
S
Y
----
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
M
S
Y
G
S
L
F
D
A
T
Q
T
K
V
L
D
V
D
G
K
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
E
Y
F
A
K
I
49
PsiBlast_CBE
93.59
73%
-64
- C4 -
-
3LC2
1
G3P1_STAAR
P:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
-----------
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
2
PsiBlast_PDB
93.34
77%
-84
- C4 -
-
5VMT
2
?
A:
[9-339]
M
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
E
K
A
H
G
--
I
E
V
A
A
V
N
D
L
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
N
P
E
E
L
P
W
G
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
R
A
G
A
R
K
V
V
I
S
A
P
G
G
N
D
V
K
T
V
V
Y
G
V
N
Q
D
I
L
D
G
-
S
E
-
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
V
S
V
L
E
R
-
P
-
A
T
K
E
E
I
N
A
A
M
K
A
A
S
-----------
S
-----------
E
S
Y
----
G
Y
N
E
D
Q
I
V
S
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
--
21
PsiBlast_CBE
93.30
80%
-78
- C4 -
-
5M6D
4
?
B:
[23-353]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
--
V
E
V
T
R
I
N
D
L
T
D
P
V
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
K
F
I
K
V
S
A
E
R
D
P
E
Q
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
K
K
E
A
A
E
K
H
L
K
G
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
V
L
D
G
-
T
E
-
T
V
I
S
G
A
S
-
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
T
P
T
G
S
V
T
E
L
V
A
V
L
E
K
-
N
-
V
T
V
D
E
V
N
A
A
M
K
A
A
S
-----------
N
-----------
E
S
Y
----
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
M
S
Y
G
S
L
F
D
A
T
Q
T
K
V
L
D
V
D
G
K
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
E
Y
F
A
K
I
128
HHSearch
93.19
74%
-63
- C4 -
-
3LVF
2
G3P1_STAAR
P:
[3-336]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
-----------
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
27
PsiBlast_CBE
93.14
77%
-82
- C4 -
-
5VMT
2
?
B:
[9-339]
M
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
E
K
A
H
G
--
I
E
V
A
A
V
N
D
L
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
N
P
E
E
L
P
W
G
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
R
A
G
A
R
K
V
V
I
S
A
P
G
G
N
D
V
K
T
V
V
Y
G
V
N
Q
D
I
L
D
G
-
S
E
-
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
V
S
V
L
E
R
-
P
-
A
T
K
E
E
I
N
A
A
M
K
A
A
S
-----------
S
-----------
E
S
Y
----
G
Y
N
E
D
Q
I
V
S
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
--
5
PsiBlast_PDB
92.81
73%
-63
- C4 -
-
3LVF
2
G3P1_STAAR
P:
[3-336]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
-----------
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
24
PsiBlast_CBE
92.73
77%
-84
- C4 -
-
5VMT
2
?
F:
[9-339]
M
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
E
K
A
H
G
--
I
E
V
A
A
V
N
D
L
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
N
P
E
E
L
P
W
G
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
R
A
G
A
R
K
V
V
I
S
A
P
G
G
N
D
V
K
T
V
V
Y
G
V
N
Q
D
I
L
D
G
-
S
E
-
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
V
S
V
L
E
R
-
P
-
A
T
K
E
E
I
N
A
A
M
K
A
A
S
-----------
S
-----------
E
S
Y
----
G
Y
N
E
D
Q
I
V
S
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
--
47
PsiBlast_CBE
92.67
73%
-65
- C4 -
-
3LC2
2
G3P1_STAAR
R:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
-----------
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
22
PsiBlast_CBE
92.61
77%
-88
- C4 -
-
5VMT
2
?
H:
[10-339]
-
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
E
K
A
H
G
--
I
E
V
A
A
V
N
D
L
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
N
P
E
E
L
P
W
G
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
R
A
G
A
R
K
V
V
I
S
A
P
G
G
N
D
V
K
T
V
V
Y
G
V
N
Q
D
I
L
D
G
-
S
E
-
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
V
S
V
L
E
R
-
P
-
A
T
K
E
E
I
N
A
A
M
K
A
A
S
-----------
S
-----------
E
S
Y
----
G
Y
N
E
D
Q
I
V
S
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
--
48
PsiBlast_CBE
92.59
73%
-64
- C4 -
-
3LC2
2
G3P1_STAAR
Q:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
-----------
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
69
PsiBlast_CBE
92.53
73%
-61
- C4 -
-
3K9Q
3
G3P1_STAAR
P:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
G
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
-----------
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
23
PsiBlast_CBE
92.46
77%
-90
- C4 -
-
5VMT
2
?
G:
[11-339]
--
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
E
K
A
H
G
--
I
E
V
A
A
V
N
D
L
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
N
P
E
E
L
P
W
G
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
R
A
G
A
R
K
V
V
I
S
A
P
G
G
N
D
V
K
T
V
V
Y
G
V
N
Q
D
I
L
D
G
-
S
E
-
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
V
S
V
L
E
R
-
P
-
A
T
K
E
E
I
N
A
A
M
K
A
A
S
-----------
S
-----------
E
S
Y
----
G
Y
N
E
D
Q
I
V
S
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
--
58
PsiBlast_CBE
92.43
73%
-63
- C4 -
-
3LC1
3
G3P1_STAAR
O:
[2-334]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
-----------
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
10
PsiBlast_PDB
92.36
73%
-66
- C4 -
-
3LC2
2
G3P1_STAAR
O:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
-----------
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
59
PsiBlast_CBE
92.32
73%
-63
- C4 -
-
3KV3
3
G3P1_STAAR
R:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
-----------
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
9
PsiBlast_PDB
92.19
73%
-64
- C4 -
-
3L6O
-
G3P1_STAAR
Q:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
-----------
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
61
PsiBlast_CBE
91.96
73%
-64
- C4 -
-
3KV3
3
G3P1_STAAR
P:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
-
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
-----------
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
86
PsiBlast_CBE
76.33
53%
-48
- C4 -
-
2EP7
1
G3P_AQUAE
A:
[3-338]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
R
E
E
--
I
E
I
V
A
I
N
D
L
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
E
A
K
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
-
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
-
S
S
V
E
E
V
N
E
K
F
R
E
A
A
-----------
Q
K
Y
R
E
SGKVYLK
E
I
L
----
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
----
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
--
131
HHSearch
75.99
56%
-46
- C4 -
-
2EP7
1
G3P_AQUAE
B:
[2-340]
-
A
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
R
E
E
--
I
E
I
V
A
I
N
D
L
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
E
A
K
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
-
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
-
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGKVYL
K
-----------
E
I
L
----
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
----
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
85
PsiBlast_CBE
74.99
53%
-48
- C4 -
-
2EP7
1
G3P_AQUAE
B:
[2-338]
-
A
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
R
E
E
--
I
E
I
V
A
I
N
D
L
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
E
A
K
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
-
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
-
S
S
V
E
E
V
N
E
K
F
R
E
A
A
-----------
Q
K
Y
R
E
SGKVYLK
E
I
L
----
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
----
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
--
84
PsiBlast_CBE
70.12
54%
10
- C4 -
-
1HDG
1
G3P_THEMA
O:
[2-332]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
K
N
PD
I
E
V
V
A
I
N
D
L
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
-----------
E
-----------
G
R
L
KGII
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
--
I
G
G
K
-
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
83
PsiBlast_CBE
69.81
54%
5
- C4 -
-
1HDG
1
G3P_THEMA
Q:
[2-332]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
K
N
PD
I
E
V
V
A
I
N
D
L
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
-----------
E
-----------
G
R
L
KGII
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
--
I
G
G
K
-
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M