@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U3V4: (2017-12-25 )
MGRFKSTLDVKCPTKEIAMLDEIKMIESVAPDIIEVLQERYKILRNIYWMQPIGRRSLSESMGITERVLRTETDLLKNLNLIDTSKSGMTLTTKGEEVYQSLENFMDQLLGTHQTEQQLAEYFGNQRCIVVSGNSEEQTKVADAFGEALSEALDRLLPEGENIIAVMGGTTMAVVAEQLSNLENKKRHNLFVPARGGIGEAITVQANSVSARMAAKANGNHRALYVPEQLSLATYNSLLNEPSIQEVLNLISEANCVIHSIGRALHMAARRKMTEKELVMLKQANAVAESFGYFFNEKGEVVYKVPRIGIELQDLEKVPIIMAIAGGKSKAKAIRAYMKNAPKQTWLITDEAAANEILKGVTL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......-120.......130.......140.......150.......-160.....-..170.-....-...180.......190.......200....--.--....210.-......220.....-..230.-...---...240.......250.......260---....-----.-.---.270....-..-..280........290.......300---..---.-----.----...310.......320.......330.....-..340........350.......360.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGRFKS
T
L
DVKCP
T
K
E
I
A
M
L
D
E
I
K
M
I
E
S
V
A
P
D
I
I
E
V
L
Q
E
R
Y
K
I
L
R
N
I
Y
WMQPI
G
R
R
S
L
S
E
SM
G
I
T
E
R
V
L
R
T
E
T
D
L
L
KNLNLIDTSKS
G
M
T
L
TT
K
G
E
E
V
Y
Q
S
L
E
N
F
M
D
Q
L
LGT
H
Q
T
E
Q
Q
L
-
A
E
Y
FGN
Q
R
C
I
V
V
SGN
S
E
E
Q
T
K
V
A
D
A
F
G
E
A
L
S
E
A
L
D
R
LLPE-GE
N
I
I
A
V
M-GG
T
T
-
M
-
A
V
V
A
-
E
Q
L
S
N
L
ENKKRH
N
L
F
V
PARGGIG
E
--
A
I
T
V
--
Q
--ANS
V
S
A
R
M
-
A
AKANGN
H
R
A
L
YV
P
-
E
Q
L
S
L
A
-
T
Y
N
---
S
LLNEP
S
I
Q
E
V
L
N
L
I
S
E
A
N
C
V
I
H
S
I
G
---
R
A
L
H
-----
M
-
A
---
A
R
R-KM
T
E
-
K
E
-
L
V
M
-
L
K
Q
A
N
A
V
A
E
S
F
G
Y
F
FNEKG
E
V
V
---
Y
K---V-----P----RI
G
I
E
L
Q
DLEKV
P
I
I
M
A
IAGGK
S
K
A
K
A
I
R
A
Y
-
M
KNA-PK
Q
T
W
L
IT
D
E
A
A
A
N
E
I
L
KGVTL
1
PsiBlast_PDB
93.51
71%
-124
- C3 -
-
2O0M
-
?
A:
[95-341]
----------------------------------------------------------------------------------------------------------------
H
Q
I
E
K
E
M
-
T
Q
Y
F
G
I
Q
R
C
I
V
V
A
G
D
S
D
I
Q
K
K
V
L
S
D
F
G
D
V
L
T
N
T
L
N
L
L
L
P
N
-
G
E
N
T
I
A
V
M
-
G
G
T
T
-
M
-
A
M
V
A
-
E
N
M
G
S
L
E
T
E
K
R
H
N
L
F
V
P
A
R
G
G
I
G
E
--
A
V
S
V
--
Q
--
A
N
S
I
S
A
V
M
-
A
N
K
T
G
G
N
Y
R
A
L
Y
V
P
-
E
Q
L
S
R
E
-
T
Y
N
---
S
L
L
Q
E
P
S
I
Q
E
V
L
T
L
I
S
H
A
N
C
V
V
H
S
I
G
---
R
A
L
H
-----
M
-
A
---
A
R
R
-
K
M
S
D
-
D
E
-
M
V
M
-
L
K
Q
K
N
A
V
A
E
S
F
G
Y
F
F
D
E
E
G
K
V
V
---
Y
K
---
I
-----
P
----
R
I
G
L
Q
L
K
N
L
Q
E
I
P
Y
V
V
A
I
A
G
G
K
T
K
A
K
A
I
R
A
Y
-
M
K
N
A
-
P
K
Q
T
W
L
I
T
D
E
A
A
A
N
E
I
L
K
----
25
HHSearch
82.81
73%
-20
- C3 -
-
2O0M
-
?
A:
[95-341]
----------------------------------------------------------------------------------------------------------------
H
Q
I
E
K
E
M
-
T
Q
Y
F
G
I
Q
R
C
I
V
V
A
G
D
S
D
I
Q
K
K
V
L
S
D
F
G
D
V
L
T
N
T
L
N
L
L
L
P
N
G
E
N
-
T
I
A
V
M
-
G
G
T
T
-
M
-
A
M
V
A
-
E
N
M
G
S
L
E
T
E
K
R
H
N
L
F
V
P
A
R
G
G
I
G
E
--
A
V
S
V
--
Q
--
A
N
S
I
S
A
V
M
-
A
N
K
T
G
G
N
Y
R
A
L
Y
V
P
-
E
Q
L
S
R
E
-
T
Y
N
---
S
L
L
Q
E
P
S
I
Q
E
V
L
T
L
I
S
H
A
N
C
V
V
H
S
I
G
---
R
A
L
H
-----
M
-
A
---
A
R
R
-
K
M
-
S
-
D
D
E
M
V
M
-
L
K
Q
K
N
A
V
A
E
S
F
G
Y
F
F
D
E
E
G
K
V
V
---
Y
----
K
I----
P
----
R
I
G
L
Q
L
K
N
L
Q
E
I
P
Y
V
V
A
I
A
G
G
K
T
K
A
K
A
I
R
A
Y
-
M
K
N
A
P
K
Q
T
-
W
L
I
T
D
E
A
A
A
N
E
I
L
K
----
22
PsiBlast_CBE
79.55
44%
-104
- C3 -
-
3BXG
1
CGGR_BACSU
B:
[5-253]
-----------------------------------------------------------------------------------------------------------
D
V
L
G
L
T
L
L
E
K
T
L
-
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
P
W
V
K
K
E
M
G
R
A
A
V
A
C
M
K
K
R
F
-
S
-
G
K
N
I
V
A
V
T
-
G
G
T
T
-
I
-
E
A
V
A
-
E
M
M
T
P
-
D
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
--
D
V
K
N
--
Q
--
A
N
T
I
C
A
H
M
-
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
-
G
Q
L
S
Q
G
-
A
Y
S
---
S
I
I
E
E
P
S
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
---
E
A
K
T
-----
M
-
A
---
Q
R
R
-
N
T
P
L
-
E
D
-
L
K
K
-
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
N
A
D
G
E
V
V
---
H
K
---
V
-----
H
----
S
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
-
F
K
K
--
P
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
----
21
PsiBlast_CBE
79.38
44%
-102
- C3 -
-
3BXH
1
CGGR_BACSU
B:
[5-253]
-----------------------------------------------------------------------------------------------------------
D
V
L
G
L
T
L
L
E
K
T
L
-
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
P
W
V
K
K
E
M
G
R
A
A
V
A
C
M
K
K
R
F
-
S
-
G
K
N
I
V
A
V
T
-
G
G
T
T
-
I
-
E
A
V
A
-
E
M
M
T
P
-
D
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
--
D
V
K
N
--
Q
--
A
N
T
I
C
A
H
M
-
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
-
G
Q
L
S
Q
G
-
A
Y
S
---
S
I
I
E
E
P
S
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
---
E
A
K
T
-----
M
-
A
---
Q
R
R
-
N
T
P
L
-
E
D
-
L
K
K
-
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
N
A
D
G
E
V
V
---
H
K
---
V
-----
H
----
S
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
-
F
K
K
--
P
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
----
2
PsiBlast_PDB
79.27
44%
-107
- C3 -
-
3BXE
1
CGGR_BACSU
A:
[8-253]
--------------------------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
-
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
P
W
V
K
K
E
M
G
R
A
A
V
A
C
M
K
K
R
F
-
S
-
G
K
N
I
V
A
V
T
-
G
G
T
T
-
I
-
E
A
V
A
-
E
M
M
T
P
-
D
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
--
D
V
K
N
--
Q
--
A
N
T
I
C
A
H
M
-
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
-
G
Q
L
S
Q
G
-
A
Y
S
---
S
I
I
E
E
P
S
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
---
E
A
K
T
-----
M
-
A
---
Q
R
R
-
N
T
P
L
-
E
D
-
L
K
K
-
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
N
A
D
G
E
V
V
---
H
K
---
V
-----
H
----
S
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
-
F
K
K
--
P
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
----
3
PsiBlast_PDB
79.23
44%
-110
- C3 -
-
3BXF
1
CGGR_BACSU
A:
[5-253]
-----------------------------------------------------------------------------------------------------------
D
V
L
G
L
T
L
L
E
K
T
L
-
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
P
W
V
K
K
E
M
G
R
A
A
V
A
C
M
K
K
R
F
-
S
-
G
K
N
I
V
A
V
T
-
G
G
T
T
-
I
-
E
A
V
A
-
E
M
M
T
P
-
D
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
--
D
V
K
N
--
Q
--
A
N
T
I
C
A
H
M
-
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
-
G
Q
L
S
Q
G
-
A
Y
S
---
S
I
I
E
E
P
S
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
---
E
A
K
T
-----
M
-
A
---
Q
R
R
-
N
T
P
L
-
E
D
-
L
K
K
-
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
N
A
D
G
E
V
V
---
H
K
---
V
-----
H
----
S
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
-
F
K
K
--
P
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
----
4
PsiBlast_PDB
78.74
44%
-103
- C3 -
-
3BXG
1
CGGR_BACSU
A:
[8-253]
--------------------------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
-
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
P
W
V
K
K
E
M
G
R
A
A
V
A
C
M
K
K
R
F
-
S
-
G
K
N
I
V
A
V
T
-
G
G
T
T
-
I
-
E
A
V
A
-
E
M
M
T
P
-
D
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
--
D
V
K
N
--
Q
--
A
N
T
I
C
A
H
M
-
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
-
G
Q
L
S
Q
G
-
A
Y
S
---
S
I
I
E
E
P
S
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
---
E
A
K
T
-----
M
-
A
---
Q
R
R
-
N
T
P
L
-
E
D
-
L
K
K
-
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
N
A
D
G
E
V
V
---
H
K
---
V
-----
H
----
S
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
-
F
K
K
--
P
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
----
5
PsiBlast_PDB
78.67
44%
-107
- C3 -
-
3BXH
1
CGGR_BACSU
A:
[8-253]
--------------------------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
-
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
P
W
V
K
K
E
M
G
R
A
A
V
A
C
M
K
K
R
F
-
S
-
G
K
N
I
V
A
V
T
-
G
G
T
T
-
I
-
E
A
V
A
-
E
M
M
T
P
-
D
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
--
D
V
K
N
--
Q
--
A
N
T
I
C
A
H
M
-
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
-
G
Q
L
S
Q
G
-
A
Y
S
---
S
I
I
E
E
P
S
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
---
E
A
K
T
-----
M
-
A
---
Q
R
R
-
N
T
P
L
-
E
D
-
L
K
K
-
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
N
A
D
G
E
V
V
---
H
K
---
V
-----
H
----
S
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
-
F
K
K
--
P
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
----
24
PsiBlast_CBE
78.15
44%
-103
- C3 -
-
3BXE
1
CGGR_BACSU
B:
[5-253]
-----------------------------------------------------------------------------------------------------------
D
V
L
G
L
T
L
L
E
K
T
L
-
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
P
W
V
K
K
E
M
G
R
A
A
V
A
C
M
K
K
R
F
-
S
-
G
K
N
I
V
A
V
T
-
G
G
T
T
-
I
-
E
A
V
A
-
E
M
M
T
P
-
D
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
--
D
V
K
N
--
Q
--
A
N
T
I
C
A
H
M
-
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
-
G
Q
L
S
Q
G
-
A
Y
S
---
S
I
I
E
E
P
S
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
---
E
A
K
T
-----
M
-
A
---
Q
R
R
-
N
T
P
L
-
E
D
-
L
K
K
-
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
N
A
D
G
E
V
V
---
H
K
---
V
-----
H
----
S
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
-
F
K
K
--
P
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
----
23
PsiBlast_CBE
77.80
44%
-105
- C3 -
-
3BXF
1
CGGR_BACSU
B:
[9-253]
---------------------------------------------------------------------------------------------------------------
L
T
L
L
E
K
T
L
-
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
P
W
V
K
K
E
M
G
R
A
A
V
A
C
M
K
K
R
F
-
S
-
G
K
N
I
V
A
V
T
-
G
G
T
T
-
I
-
E
A
V
A
-
E
M
M
T
P
-
D
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
--
D
V
K
N
--
Q
--
A
N
T
I
C
A
H
M
-
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
-
G
Q
L
S
Q
G
-
A
Y
S
---
S
I
I
E
E
P
S
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
---
E
A
K
T
-----
M
-
A
---
Q
R
R
-
N
T
P
L
-
E
D
-
L
K
K
-
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
N
A
D
G
E
V
V
---
H
K
---
V
-----
H
----
S
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
-
F
K
K
--
P
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
----
32
HHSearch
72.82
44%
-58
- C3 -
-
3BXG
1
CGGR_BACSU
B:
[8-253]
--------------------------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
-
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
P
W
V
K
K
E
M
G
R
A
A
V
A
C
M
K
K
R
F
S
G
-
K
N
-
I
V
A
V
T
-
G
G
T
T
-
I
-
E
A
V
A
-
E
M
M
T
P
D
-
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
--
D
V
K
N
--
Q
--
A
N
T
I
C
A
H
M
-
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
-
G
Q
L
S
Q
G
-
A
Y
S
---
S
I
I
E
E
P
S
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
---
E
A
K
T
-----
M
-
A
----
Q
R
-
R
N
T
P
-
L
E
D
L
K
K
-
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
N
A
D
G
E
V
V
---
H
K
---
V
-----
H
----
S
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
-
F
K
K
P
-
R
N
T
-
V
L
V
T
D
E
G
A
A
K
K
L
L
R
----
33
HHSearch
70.12
44%
-62
- C3 -
-
2OKG
-
CGGR_BACSU
A:
[8-253]
--------------------------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
-
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
P
W
V
K
K
E
M
G
R
A
A
V
A
C
M
K
K
R
F
S
G
-
K
N
-
I
V
A
V
T
-
G
G
T
T
-
I
-
E
A
V
A
-
E
M
M
T
P
D
-
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
-----
K
N
--
Q
--
A
N
T
I
C
A
H
M
-
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
-
G
Q
L
S
Q
G
-
A
Y
S
---
S
I
I
E
E
P
S
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
---
E
A
K
T
-----
M
-
A
----
Q
R
-
R
N
T
P
-
L
E
D
L
K
K
-
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
N
A
D
G
E
V
V
---
H
K
---
V
-----
H
----
S
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
-
F
K
K
P
-
R
N
T
-
V
L
V
T
D
E
G
A
A
K
K
L
L
R
----
46
Fugue
69.93
66%
27
- C3 -
-
2O0M
-
?
A:
[95-341]
-----------------------------------------------------------------------------------------------------------------
H
Q
I
E
K
E
M
T
Q
Y
F
G
I
Q
R
C
I
V
V
A
G
D
S
D
I
Q
K
K
V
L
S
D
F
G
D
V
L
T
N
T
L
N
L
L
L
P
N
-
G
-
E
N
T
I
A
V
M
G
G
T
T
M
A
M
V
A
E
N
M
G
S
L
E
T
---
E
K
R
H
N
L
F
V
P
A
R
G
G
I
G
E
--
A
V
S
V
--
Q
--
A
N
S
I
S
A
-
V
M
A
N
K
T
G
G
N
Y
R
A
L
Y
V
P
-
E
Q
L
S
R
E
-
T
Y
N
---
S
L
L
Q
E
P
S
I
Q
E
V
L
T
L
I
S
H
A
N
C
V
V
H
S
I
G
---
R
A
L
H
M
----
A
-
A
---
R
R
K
M
S
D
D
E
M
V
-----
M
L
K
Q
K
N
A
V
A
E
S
F
G
Y
F
F
D
E
E
G
K
V
V
---
Y
K
---
I
-----
P
----
R
I
G
L
Q
L
K
N
L
Q
E
I
P
Y
V
V
A
I
A
G
G
K
T
K
A
K
A
I
R
A
Y
M
K
N
-
A
-
P
K
Q
T
W
L
I
T
D
E
A
A
A
N
E
I
L
K
----
26
HHSearch
65.45
25%
-66
- C3 -
-
4L5I
-
LSRR_ECOLI
C:
[13-316]
----------------------------------
M
C
E
E
E
Q
V
A
R
I
A
W
F
Y
Y
H
D
G
L
T
Q
S
E
I
S
D
R
L
G
L
T
R
L
K
V
S
R
L
L
E
K
G
H
Q
S
G
I
I
R
V
Q
I
N
S
R
----------------
F
---
E
G
C
L
E
Y
E
T
Q
L
-
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
A
D
--
A
D
V
G
G
R
L
G
I
G
A
A
H
M
L
M
S
L
L
Q
P
-
Q
Q
-
M
L
A
I
G
-
F
G
E
A
-
T
-
M
N
T
L
-
Q
R
L
S
G
F
-
I
S
S
Q
Q
I
R
L
V
T
L
S
G
G
V
G
S
Y-
M
T
G
I
---------
G
Q
-
L
-
N
--
A
A
C
S
V
N
I
I
P
A
P
-
L
R
A
S
S
A
D
I
A
R
---
T
L
K
N
E
N
C
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
---
A
V
S
Q
-----
Q
D
D
ATI
I
R
S
-
G
Y
I
S
-
Q
G
E
Q
L
M
-
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
D
A
K
G
D
V
V
---
T
----
N
IKIHN
E
----
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
-
M
K
G
G
-
Y
I
N
-
A
L
V
T
D
Q
D
T
A
A
A
I
L
R
----
48
Fugue
64.29
16%
-63
- C3 -
-
2W48
2
SORC_KLEPN
A:
[4-315]
----------------------------------
S
D
D
I
R
L
I
V
K
I
A
Q
L
Y
Y
E
Q
D
M
T
Q
A
Q
I
A
R
E
L
G
I
Y
R
T
T
I
S
R
L
L
K
R
G
R
E
Q
G
I
V
T
I
A
I
N
-------------------
Y
D
Y
N
E
N
L
W
L
E
Q
Q
L
-
K
Q
K
F
G
L
K
E
A
V
V
A
S
S
E
E
E
Q
L
S
A
M
G
Q
H
G
A
L
L
V
D
R
L
L
-----
E
-
P
G
D
I
I
G
F
S
-
W
G
R
A
-
V
-
R
S
L
V
-
E
N
L
P
Q
-
R
S
Q
S
R
Q
V
I
C
V
P
I
I
G
G
P
S
G
--
K
L
E
S
--
R
YH
V
N
T
L
T
Y
G
A
-
A
A
R
L
K
A
E
S
H
L
A
D
F
P
A
L
L
D
N
P
L
-
I
R
N
---
G
I
M
Q
S
Q
H
F
K
T
I
S
S
Y
W
D
S
L
D
V
A
L
V
G
I
G
S
PA
I
R
D
G
-----
A
-
N
---
W
H
A
-
F
Y
G
S
-
E
E
-
S
D
D
-
L
N
A
R
H
V
A
G
D
I
C
S
R
F
Y
D
I
N
G
G
L
V
DTN
M
S
---
E
-----
K
----
T
L
S
I
E
M
A
K
L
R
Q
A
R
Y
S
I
G
I
A
M
G
E
E
K
Y
S
G
I
L
G
A
-
L
H
G
R
-
Y
I
-
N
C
L
V
T
N
R
E
T
A
E
L
L
L
K
----
27
HHSearch
62.47
19%
-53
- C3 -
-
2W48
-
SORC_KLEPN
C:
[5-315]
----------------------------------
D
D
I
R
L
I
V
K
I
A
Q
L
Y
Y
E
-
Q
D
M
T
Q
A
Q
I
A
R
E
L
G
I
Y
R
T
T
I
S
R
L
L
K
R
G
R
E
Q
G
I
V
T
I
A
I
N
Y
----------------
D
Y
---
N
E
N
L
W
L
E
Q
Q
L
-
K
Q
K
F
G
L
K
E
A
V
V
A
--------
E
Q
L
S
A
M
G
Q
H
G
A
L
L
V
D
R
L
L
E
P
-
G
D
-
I
I
G
F
S
-
W
G
R
A
-
V
-
R
S
L
V
-
E
N
L
P
Q
R
-
S
Q
S
R
Q
V
I
C
V
P
I
I
G
G
P
S
G
KL
E
S
R
Y
--
H
--
V
N
T
L
T
Y
G
A
-
A
A
R
L
K
A
E
S
H
L
A
D
F
P
-
A
L
L
D
N
P
L
I
R
N
---
G
I
M
Q
S
Q
H
F
K
T
I
S
S
Y
W
D
S
L
D
V
A
L
V
G
I
G
---
S
P
A
--------
D
GA-
N
W
H
-
A
F
Y
G
-
S
E
E
S
D
D
-
L
N
A
R
H
V
A
G
D
I
C
S
R
F
Y
D
I
N
G
G
------
T
NMS
E
-----
K
----
T
L
S
I
E
M
A
K
L
R
Q
A
R
Y
S
I
G
I
A
M
G
E
E
K
Y
S
G
I
L
G
A
-
L
H
G
R
-
Y
I
N
-
C
L
V
T
N
R
E
T
A
E
L
L
L
K
----
28
HHSearch
61.63
19%
-62
- C3 -
-
2W48
1
SORC_KLEPN
B:
[5-315]
----------------------------------
D
D
I
R
L
I
V
K
I
A
Q
L
Y
Y
E
-
Q
D
M
T
Q
A
Q
I
A
R
E
L
G
I
Y
R
T
T
I
S
R
L
L
K
R
G
R
E
Q
G
I
V
T
I
A
I
N
Y
----------------
D
Y
---
N
E
N
L
W
L
E
Q
Q
L
-
K
Q
K
F
G
L
K
E
A
V
V
A
S
S
D
G
L
L
E
E
E
Q
L
S
A
M
G
Q
H
G
A
L
L
V
D
R
L
L
E
P
-
G
D
-
I
I
G
F
S
-
W
G
R
A
-
V
-
R
S
L
V
-
E
N
L
P
Q
R
-
S
Q
S
R
Q
V
I
C
V
P
I
I
G
G
P
S
G
KL
E
S
R
Y
--
H
--
V
N
T
L
T
Y
G
A
-
A
A
R
L
K
A
E
S
H
L
A
D
F
P
-
A
L
L
D
N
P
L
I
R
N
---
G
I
M
Q
S
Q
H
F
K
T
I
S
S
Y
W
D
S
L
D
V
A
L
V
G
I
G
---
S
P
A
I
-----
R
-
D
GA-
N
W
H
-
A
F
Y
G
-
S
E
E
S
D
D
-
L
N
A
R
H
V
A
G
D
I
C
S
R
F
Y
D
I
N
G
G
L
V
---
D
T
NMS
E
-----
K
----
T
L
S
I
E
M
A
K
L
R
Q
A
R
Y
S
I
G
I
A
M
G
E
E
K
Y
S
G
I
L
G
A
-
L
H
G
R
-
Y
I
N
-
C
L
V
T
N
R
E
T
A
E
L
L
L
K
----
12
PsiBlast_PDB
59.66
27%
-35
- C3 -
-
4L51
1
LSRR_ECOLI
A:
[19-265]
--------------------------------------------------------------------------------------------------------------
G
C
L
E
Y
E
T
Q
L
-
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
-----
D
V
G
G
R
L
G
I
G
A
A
H
M
L
M
S
L
L
Q
P
-
Q
Q
M
L
A
I
G
F
-
G
E
A
T
-
M
-
N
T
L
--
Q
R
L
S
G
F
I
S
S
Q
Q
I
R
L
-
V
T
L
S
G
G
V
G
S
--
Y
M
T
G
I
G
Q
--
L
N
A
------
A
C
S
V
N
------
I
I
P
-
A
P
L
R
A
S
-
S
A
D
I
A
R
T
L
K
N
E
N
C
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
---
A
V
S
Q
QDDA
T
I
-
I
---
R
S
G
-
Y
I
S
Q
-
G
E
-
Q
L
M
-
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
D
A
K
G
D
V
V
---
T
N
---
I
-----
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
-
M
K
G
G
-
Y
I
N
A
-
L
V
T
D
Q
D
T
A
A
A
I
L
R
----
6
PsiBlast_PDB
59.55
27%
-31
- C3 -
-
4L5I
-
LSRR_ECOLI
A:
[70-316]
--------------------------------------------------------------------------------------------------------------
G
C
L
E
Y
E
T
Q
L
-
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
A
D
--
A
D
V
G
G
R
L
G
I
G
A
A
H
M
L
M
S
L
L
Q
P
-
Q
Q
M
L
A
I
G
F
-
G
E
A
T
-
M
-
N
T
L
--
Q
R
L
S
G
F
I
S
S
Q
Q
I
R
L
-
V
T
L
S
G
G
V
G
S
--
Y
M
T
G
IG
Q
--
L
N
A
------
A
C
S
V
N
------
I
I
P
-
A
P
L
R
A
S
-
S
A
D
I
A
R
T
L
K
N
E
N
C
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
---
A
V
S
Q
QDDA
T
I
-
I
---
R
S
G
-
Y
I
S
Q
-
G
E
-
Q
L
M
-
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
D
A
K
G
D
V
V
---
T
N
---
I
-----
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
-
M
K
G
G
-
Y
I
N
A
-
L
V
T
D
Q
D
T
A
A
A
I
L
R
----
11
PsiBlast_PDB
59.52
27%
-28
- C3 -
-
4L50
1
LSRR_ECOLI
A:
[19-265]
--------------------------------------------------------------------------------------------------------------
G
C
L
E
Y
E
T
Q
L
-
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
A
D
----
V
G
G
R
L
G
I
G
A
A
H
M
L
M
S
L
L
Q
P
-
Q
Q
M
L
A
I
G
F
-
G
E
A
T
-
M
-
N
T
L
--
Q
R
L
S
G
F
I
S
S
Q
Q
I
R
L
-
V
T
L
S
G
G
V
G
S
--
Y
M
T
G
IG
Q
--
L
N
A
------
A
C
S
V
N
------
I
I
P
-
A
P
L
R
A
S
-
S
A
D
I
A
R
T
L
K
N
E
N
C
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
---
A
V
S
Q
QDDA
T
I
-
I
---
R
S
G
-
Y
I
S
Q
-
G
E
-
Q
L
M
-
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
D
A
K
G
D
V
V
---
T
N
---
I
-----
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
-
M
K
G
G
-
Y
I
N
A
-
L
V
T
D
Q
D
T
A
A
A
I
L
R
----