@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U475: (2017-12-26 )
MKISPALESTLDNRYNRKEFQKRGFLMIYFDNSATTPIFPQSLDAYVKTSQRIIGNPSSLHDLGNQANRLLQQARKQIADLIHVEPEEIYFTSGGTEGDNWVLKGTMIEKREYGNHMIISGVEHPAVSETAEQLKELGIEVSIAPVDKRGFVRVDELKELIRKETVLVSVMAVNNEVGSIQPIQEISDLLDDFPKIHFHVDAVQAIGKVPFSQWLTERVDFATFSAHKFHGPRGTGFIYWKKGRRLAPLLTGGGQERNQRSGTENVPGIVAMVKALRLSLEIKEQKPEQTQRLKVALINALKTYEKVTIFSEGTDYAPHILCFALKGIRGEVLVHALEEKQIFVSTTSACSSRKHMASSTLHAMHVPNDLATSAVRISLDENNSLAEVEQFMIIFKQLYKKFSAIN
Atome Classification :
(31 SA)
.........10........20........30........40.......--.50......-..60.........70........80........90........100..--...--------..110--....----.---...120-.......130...-..-..-140......-.150.......160--.--......170.......180.......190-------.---------.--.-..-....200......--.210.....-.---.--220.......230.......240--...--.-------....---250.......260.......270.......-280........290......-.300.---.--.....310--.-..---....320-..----.....--..330.......340.......350........360.......370.......380.......390.......400....--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKIS
P
A
L
E
S
T
L
DNRY
N
R
K
E
F
Q
KR
G
F
L
M
I
Y
FDNSATTPIF
P
Q
S
L
D
A
Y
V
K
--
T
S
Q
R
IIGN
P
-
S
S
L
-
H
D
L
G
N
Q
A
N
R
L
L
Q
Q
A
R
K
Q
I
A
D
L
IHV
E
P
E
E
I
Y
F
TSGGTEGD
N
W
V
L
K
--
G
T
M
--------
I
E
KR---EYGN----
H
---
M
I
ISGV-EHP
A
V
S
E
T
A
E
Q
L
K
-EL-G
I
-
E
V
S
I
A
PVDK-RG
F
V
R
V
D
E
L
K
E
L
I
R
--K--E
T
V
L
V
S
V
M
A
VNNEVGSIQ
P
I
Q
E
I
S
D
L
L
---------D---------D--F-PK-
I
H
F
H
V
D
A
V
Q
A
I
GK--V
P
F
S
Q
W
L
T
E
-R---V--D
F
A
TFSAHKFHGPRG
T
G
F
I
Y
WK---KG
R
--
R
-------
L
A
P
L
---LTGGGQERNQRSGTENV
P
G
I
V
A
M
V
K
A
L
R
L
S
-
L
E
-
I
KEQKP
E
Q
T
Q
R
L
K
V
A
L
I
-
N
A
L
K
T
---
Y
--
E
K
V
T
I
FSE--G-TD---Y
A
P
H
I
---
L
C
----
F
A
L
KG--I
R
G
E
V
L
V
H
A
LEE
K
Q
I
F
V
STT
S
A
C
-SS
R
K
H
M
A
SST
L
H
A
MHVPNDLAT
S
A
V
R
I
S
LDENN
S
L
A
E
V
E
Q
F
M
I
I
F
K
Q
L
Y
K
K
FSAIN--
6
PsiBlast_PDB
89.50
35%
0
- C- -
-
5KZ5
-
NFS1_HUMAN
1:
[1--37]
-----------------------------------
T
P
L
D
P
R
V
L
D
A
M
L
P
--
Y
L
I
N
Y
Y
G
N
P
H
S
R
T
-
H
A
Y
G
W
E
S
E
A
A
M
E
R
A
R
Q
Q
V
A
S
L
I
G
A
D
P
R
E
I
I
F
T
S
G
A
T
E
S
N
N
I
A
I
K
--
G
V
A
--------
R
F
Y
R
---
S
R
K
K
----
H
---
L
I
T
T
Q
T
-
E
H
K
C
V
L
D
S
C
R
S
L
E
-
A
E
-
G
F
-
Q
V
T
Y
L
P
V
Q
K
-
S
G
I
I
D
L
K
E
L
E
A
A
I
Q
--
P
--
D
T
S
L
V
S
V
M
T
V
N
N
E
I
G
V
K
Q
P
I
A
E
I
G
R
I
C
---------
S
---------
S
--
R
--
K
-
V
Y
F
H
T
D
A
A
Q
A
V
G
K
--
I
P
L
-
D
V
N
D
M
-
K
---
I
--
D
L
M
S
I
S
G
H
K
I
Y
G
P
K
G
V
G
A
I
Y
I
R
---
R
R
P
RV
R
-------
V
E
A
L
---
Q
S
G
G
G
Q
E
R
G
M
R
S
G
T
V
P
T
P
L
V
V
G
L
G
A
A
C
E
V
A
-
Q
Q
-
E
M
E
Y
D
H
K
R
I
S
K
L
S
E
R
L
I
Q
N
I
M
K
S
---
L
--
P
D
V
V
M
N
G
D
--
P
-
K
H
---
H
Y
P
G
C
---
I
N
----
L
S
F
A
Y
--
V
E
G
E
S
L
L
M
A
L
--
K
D
V
A
L
S
S
G
S
A
C
-
T
S
A
S
L
E
P
S
Y
V
L
R
A
I
G
T
D
E
D
L
A
H
S
S
I
R
F
G
I
G
R
F
T
T
E
E
E
V
D
-------------------
64
Fugue
89.04
39%
-46
* C1 *
-
1ECX
2
?
A:
[1-376]
-------------------------
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
--
F
Y
R
E
K
Y
G
N
P
-
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
--
T
V
A
--------
E
T
F
E
---
K
R
K
R
----
T
---
I
I
T
T
P
I
-
E
H
K
A
V
L
E
T
M
K
Y
L
S
-
M
K
-
G
F
-
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
--
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
---------
K
--
K
N
K
E
-
T
L
V
H
V
D
A
V
Q
T
I
G
K
--
I
P
F
S
-
L
E
K
L
-
E
---
V
--
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
G
V
--
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
-
V
E
-
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
-
S
G
L
M
N
------
L
G
A
H
I
I
T
P
--
L
-
E
I
---
S
L
P
N
T
---
L
S
----
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
-------------
T
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
42
HHSearch
85.83
39%
-20
- C1 -
-
1ECX
2
?
B:
[1-376]
-------------------------
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
--
F
Y
R
E
K
Y
G
N
P
-
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
--
T
V
A
--------
E
T
F
E
----
K
R
K
----
R
---
T
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
-
M
K
-
G
F
-
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
--
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
---------
K
KN
K
--
E
-
T
L
V
H
V
D
A
V
Q
T
I
G
K
--
I
P
F
S
-
L
E
K
L
-
E
---
V
--
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
G
V
--
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
-
V
E
-
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
-
S
G
L
M
N
---
L
---
G
A
H
I
I
T
P
--
L
-
E
I
---
S
L
P
N
T
---
L
S
----
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
------------
R
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
41
HHSearch
85.75
39%
-21
- C1 -
-
1EG5
2
?
A:
[1-376]
-------------------------
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
--
F
Y
R
E
K
Y
G
N
P
-
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
--
T
V
A
--------
E
T
F
E
----
K
R
K
----
R
---
T
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
-
M
K
-
G
F
-
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
--
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
---------
K
K
N
K
--
E
-
T
L
V
H
V
D
A
V
Q
T
I
G
K
--
I
P
F
S
-
L
E
K
L
-
E
---
V
--
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
G
V
--
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
-
V
E
-
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
-
S
G
L
M
N
---
L
---
G
A
H
I
I
T
P
--
L
-
E
I
---
S
L
P
N
T
---
L
S
----
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
-------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
9
PsiBlast_PDB
81.58
31%
-42
- C1 -
-
4EB7
7
ISCS2_ARCFU
A:
[2-377]
---------------------------
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
--
G
Y
A
--------
M
R
N
A
---
R
K
G
K
----
H
---
I
L
V
S
A
V
-
E
H
M
S
V
I
N
P
A
K
F
L
Q
-
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
---------
G
-----
K
-
A
A
L
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
---
V
E
-
K
---
I
GA
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
-
N
V
L
K
I
------
E
E
S
Y
L
N
G
H
--
P
-
E
K
---
R
L
P
N
N
---
V
N
----
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
-
T
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
--
21
PsiBlast_CBE
81.29
41%
-11
- C1 -
-
1ECX
2
?
B:
[1-366]
-------------------------
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
--
F
Y
R
E
K
Y
G
N
P
-
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
TV
A
E
T
--------
F
E
K
R
---
K
--
R
----
T
---
I
I
T
T
P
I
-
E
H
K
A
V
L
E
T
M
K
Y
L
S
-
M
K
-
G
F
-
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
--
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
---------
K
--
K
-
N
K
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
--
I
P
F
S
L
E
K
L
E
-----
V
--
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
G
V
--
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
-
V
E
-
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
-
S
G
L
M
N
---
L
---
G
A
H
I
I
T
P
--
L
-
E
I
---
S
L
P
N
T
---
L
S
----
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
------------
R
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
----------------
1
PsiBlast_PDB
81.21
41%
-12
- C1 -
-
1ECX
2
?
A:
[1-366]
-------------------------
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
--
F
Y
R
E
K
Y
G
N
P
-
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
T
--------
F
E
K
R
---
K
--
R
----
T
---
I
I
T
T
P
I
-
E
H
K
A
V
L
E
T
M
K
Y
L
S
-
M
K
-
G
F
-
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
--
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
---------
K
--
K
-
N
K
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
--
I
P
F
S
L
E
K
L
E
-----
V
--
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
G
V
--
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
-
V
E
-
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
-
S
G
L
M
N
---
L
---
G
A
H
I
I
T
P
--
L
-
E
I
---
S
L
P
N
T
---
L
S
----
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
-------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
----------------
65
Fugue
80.78
33%
-2
- C1 -
-
4ISY
3
ISCSL_MYCTU
A:
[12-398]
--------------------------
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
--
V
Q
-
R
T
I
G
N
A
-
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
--
G
I
Y
--------
W
A
R
R
---
D
A
E
P
----
H
RR
R
I
V
T
T
E
V
-
E
H
H
A
V
L
D
S
V
N
W
L
V
-
E
H
E
G
A
-
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
--
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
---------
M
---------
E
--
F
--
G
-
V
P
M
H
S
D
A
I
Q
A
V
G
Q
--
L
P
L
D
-
F
G
A
S
-
G
---
L
--
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
---
R
D
V
--
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
-
V
D
-
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
-
E
G
V
L
A
E--
I
--
D
D
V
C
L
--
N
--
G
-
A
D
---
D
P
M
R
L
A
G
N
A
H
----
F
T
F
R
G
--
C
E
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
P
---------
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
LA
10
PsiBlast_PDB
80.44
31%
-38
- C1 -
-
4HVK
11
ISCS2_ARCFU
A:
[2-377]
---------------------------
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
--
G
Y
A
--------
M
R
N
A
---
R
K
G
K
----
H
---
I
L
V
S
A
V
-
E
H
M
S
V
I
N
P
A
K
F
L
Q
-
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
---------
G
-----
K
-
A
A
L
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
---
V
E
-
K
---
I
GA
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
-
N
V
L
K
I
------
E
E
S
Y
L
N
G
H
--
P
-
E
K
---
R
L
P
N
N
---
V
N
----
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
---------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
--
2
PsiBlast_PDB
80.30
40%
-11
- C1 -
-
1EG5
2
?
A:
[3-366]
---------------------------
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
--
F
Y
R
E
K
Y
G
N
P
-
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
T
--------
F
E
K
R
---
K
--
R
----
T
---
I
I
T
T
P
I
-
E
H
K
A
V
L
E
T
M
K
Y
L
S
-
M
K
-
G
F
-
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
--
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
---------
K
--
K
-
N
K
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
--
I
P
F
S
L
E
K
L
E
-----
V
--
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
G
V
--
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
-
V
E
-
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
-
S
G
L
M
N
---
L
---
G
A
H
I
I
T
P
--
L
-
E
I
---
S
L
P
N
T
---
L
S
----
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
-------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
----------------
23
PsiBlast_CBE
79.90
35%
-69
- C1 -
-
5USR
1
?
C:
[28-389]
---------------------------
L
Y
M
D
V
Q
A
T
T
P
L
D
P
R
V
L
D
A
M
L
P
--
Y
L
I
N
Y
Y
G
----------
G
W
E
S
E
A
A
M
E
R
A
R
Q
Q
V
A
S
L
I
G
A
D
P
R
E
I
I
F
T
S
G
A
T
E
S
N
N
I
A
I
K
--
G
V
A
--------
R
F
Y
R
---
S
R
K
K
----
H
---
L
I
T
T
Q
T
-
E
H
K
C
V
L
D
S
C
R
S
L
E
-
A
E
-
G
F
-
Q
V
T
Y
L
P
V
Q
K
-
S
G
I
I
D
L
K
E
L
E
A
A
I
Q
--
P
--
D
T
S
L
V
S
V
M
T
V
N
N
E
I
G
V
K
Q
P
I
A
E
I
G
R
I
C
---------
S
---------
S
--
R
--
K
-
V
Y
F
H
T
D
A
A
Q
A
V
G
K
--
I
P
L
D
V
N
-
D
M
-
K
---
I
--
D
L
M
S
I
S
G
H
K
I
Y
G
P
K
G
V
G
A
I
Y
I
R
---
R
R
P
R
V
R
-------
V
E
A
L
---
Q
------------
T
V
P
T
P
L
V
V
G
L
G
A
A
C
E
V
A
-
Q
Q
-
E
M
E
Y
D
H
K
R
I
S
K
L
S
E
R
L
I
Q
N
I
M
K
S
---
L
--
P
D
V
V
M
N
G
D
--
P
-
K
H
---
H
Y
P
G
C
---
I
N
----
L
S
F
A
Y
--
V
E
G
E
S
L
L
M
A
L
--
K
D
-----------------
S
Y
V
L
R
A
I
G
T
D
E
D
L
A
H
S
S
I
R
F
G
I
G
R
F
T
T
E
E
E
V
D
-------------------
7
PsiBlast_PDB
79.49
32%
-38
- C1 -
-
4R5F
10
ISCS2_ARCFU
A:
[2-377]
---------------------------
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
--
G
Y
A
--------
M
R
N
A
---
R
K
G
K
----
H
---
I
L
V
S
A
V
-
E
H
M
S
V
I
N
P
A
K
F
L
Q
-
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
---------
G
-----
K
-
A
A
L
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
---
V
E
-
K
---
I
GA
D
M
L
T
I
S
S
N
K
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
-
N
V
L
K
I
------
E
E
S
Y
L
N
G
H
--
P
-
E
K
---
R
L
P
N
N
---
V
N
----
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
---------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
--
24
PsiBlast_CBE
78.54
31%
-42
- C1 -
-
4EB7
4
ISCS2_ARCFU
B:
[2-377]
---------------------------
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
--
G
Y
A
--------
M
R
N
A
---
R
K
G
K
----
H
---
I
L
V
S
A
V
-
E
H
M
S
V
I
N
P
A
K
F
L
Q
-
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
---------
G
-----
K
-
A
A
L
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
---
V
E
-
K
---
I
GA
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
-
N
V
L
K
I
------
E
E
S
Y
L
N
G
H
--
P
-
E
K
---
R
L
P
N
N
---
V
N
----
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
--
25
PsiBlast_CBE
78.32
31%
-44
- C1 -
-
4EB5
5
ISCS2_ARCFU
B:
[2-377]
---------------------------
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
--
G
Y
A
--------
M
R
N
A
---
R
K
G
K
----
H
---
I
L
V
S
A
V
-
E
H
M
S
V
I
N
P
A
K
F
L
Q
-
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
---------
G
-----
K
-
A
A
L
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
---
V
E
-
K
---
I
GA
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
-
N
V
L
K
I
------
E
E
S
Y
L
N
G
H
--
P
-
E
K
---
R
L
P
N
N
---
V
N
----
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
--
44
HHSearch
77.46
32%
-2
- C1 -
-
4ISY
2
ISCSL_MYCTU
C:
[12-394]
--------------------------
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
--
V
Q
R
T
I
-
G
N
A
-
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
--
G
I
Y
--------
W
A
R
R
DAE
P
H
R
R
----
R
---
I
V
T
T
E
V
-
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
-
G
A
-
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
SH
D
--
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
---------
M
---------
E
--
F
--
G
-
V
P
M
H
S
D
A
I
Q
A
V
G
Q
--
L
P
L
D
-
F
G
A
S
-
G
---
L
--
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
---
R
D
V
--
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
-
V
D
-
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
-
E
G
V
L
A
E--
I
--
D
D
V
C
L
N
G
A
--
D
D
P
M
---
R
L
A
G
N
---
A
H
----
F
T
F
R
G
--
C
E
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
A
--------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
----
8
PsiBlast_PDB
77.12
31%
-38
- C1 -
-
4EB5
6
ISCS2_ARCFU
A:
[2-377]
---------------------------
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
--
G
Y
A
--------
M
R
N
A
---
R
K
G
K
----
H
---
I
L
V
S
A
V
-
E
H
M
S
V
I
N
P
A
K
F
L
Q
-
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
---------
G
-----
K
-
A
A
L
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
---
V
E
-
K
---
I
GA
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
-
N
V
L
K
I
------
E
E
S
Y
L
N
G
H
--
P
-
E
K
---
R
L
P
N
N
---
V
N
----
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
--
39
HHSearch
76.07
32%
-1
- C1 -
-
4HVK
11
ISCS2_ARCFU
A:
[2-376]
---------------------------
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
--
G
Y
A
M
R
N
A----
R
-------
K
G
K
----
H
---
I
L
V
S
A
V
-
E
H
M
S
V
I
N
P
A
K
F
L
Q
-
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
---------
G
-----
K
-
A
A
L
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
-
V
E
K
I
-
G
---
A
--
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
-
A
M
-
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
-
D
N
V
L
K
---
I
--
E
E
S
Y
L
N
G
H
--
P
-
E
K
---
R
L
P
N
N
---
V
N
----
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
---------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
40
HHSearch
73.49
32%
3
- C1 -
-
4EB5
6
ISCS2_ARCFU
A:
[2-376]
---------------------------
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
--
G
Y
A
M
R
N
A----
R
-------
K
G
K
----
H
---
I
L
V
S
A
V
-
E
H
M
S
V
I
N
P
A
K
F
L
Q
-
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
---------
G
-----
K
-
A
A
L
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
-
V
E
K
I
-
G
---
A
--
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
-
A
M
-
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
-
D
N
V
L
K
---
I
--
E
E
S
Y
L
N
G
H
--
P
-
E
K
---
R
L
P
N
N
---
V
N
----
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
27
PsiBlast_CBE
73.09
33%
-16
- C1 -
-
4ISY
2
ISCSL_MYCTU
C:
[14-385]
----------------------------
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
--
V
-
Q
R
T
I
G
N
A
-
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
--
G
I
Y
--------
W
A
R
R
---
D
A
E
P
----
H
RRR
I
V
T
T
E
V
-
E
H
H
A
V
L
D
S
V
N
W
L
V
-
E
H
E
G
A
-
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
--
S
HD
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
---------
M
---------
E
--
F
--
G
-
V
P
M
H
S
D
A
I
Q
A
V
G
Q
--
L
P
L
-
D
F
G
A
S
-
G
---
L
--
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
---
R
D
V
--
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
-
V
D
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
-
G
V
L
A
E
---
I
--
D
D
V
C
L
--
N
--
G
-
A
D
---
D
-
P
M
R
---
L
A
GNAH
F
T
F
R
G
--
C
E
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
A
--------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
-------------
33
PsiBlast_CBE
72.69
32%
7
- C1 -
-
3GZC
2
SCLY_HUMAN
B:
[27-431]
---------------------------
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
M
T
K
--
A
M
W
E
A
W
G
N
P
-
S
S
P
-
Y
S
A
G
R
K
A
K
D
I
I
N
A
A
R
E
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
--
S
V
V
KHFHANQ-
T
----------GAKP
H
---
F
I
T
S
S
V
-
E
H
D
S
I
R
L
P
L
E
H
L
V
-
E
E
-
Q
V
A
A
V
T
F
V
P
V
S
K
V
S
G
Q
T
E
V
D
D
I
L
A
A
V
R
--
P
--
T
T
R
L
V
T
I
M
L
A
N
N
E
T
G
I
V
M
P
V
P
E
I
S
Q
R
I
---------
K
ALNQERVAA
G
--
L
-
P
P
-
I
L
V
H
T
D
A
A
Q
A
L
G
K
------
Q
R
V
D
V
-
E
DLG
V
--
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
I
R
GLG
E
F
T
--
P
-------
L
Y
P
M
---
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
E
L
V
-
T
Q
-
N
C
E
A
Y
E
A
H
M
R
D
V
R
D
Y
L
E
-
E
R
L
E
A
EFG
Q
--
K
R
I
H
L
N
S
Q
FP
G
-
T
Q
---
R
L
P
N
T
---
C
N
----
F
S
I
R
G
--
P
R
L
Q
G
H
V
V
L
A
Q
C
R
V
L
M
A
S
V
G
A
A
C
H
S
D
H
G
D
Q
P
S
P
V
L
L
S
Y
G
V
P
F
D
V
A
R
N
A
L
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
V
V
Q
D
L
K
Q
-----------
31
PsiBlast_CBE
71.74
32%
15
- C1 -
-
3A9Y
4
SCLY_RAT
B:
[20-428]
---------------------------
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
--
A
M
K
E
A
W
G
N
P
-
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
--
S
T
V
R
C
F
H
E
Q
Q-----------
T
R
P
--
H
---
F
I
T
C
T
V
-
E
H
D
S
I
R
L
P
L
E
H
L
V
-
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
---------
G
--
L
-
P
R
-
V
L
V
H
T
D
A
A
Q
A
L
G
K
RR
V
D
V
E
D
L
----
G
---
V
--
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
---
G
V
G
--
K
-------
L
T
P
L
Y
P
M
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
-
S
E
-
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
---
E
FG
K
R
I
H
L
N
S
R
FP
G
-
V
E
---
R
L
P
N
T
---
C
N
----
F
S
I
Q
G
SQ
L
R
G
Y
M
V
L
A
Q
C
Q
--
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
14
PsiBlast_PDB
71.54
32%
7
- C1 -
-
3A9Z
3
SCLY_RAT
A:
[20-428]
---------------------------
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
--
A
M
K
E
A
W
G
N
P
-
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
--
S
T
V
R
C
F
H
E
Q
Q
T
L
Q
--------
T
R
P
--
H
---
F
I
T
C
T
V
-
E
H
D
S
I
R
L
P
L
E
H
L
V
-
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
---------
G
--
L
-
P
R
-
V
L
V
H
T
D
A
A
Q
A
L
G
K
RR
V
D
V
E
D
L
----
G
---
V
--
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
---
G
V
G
--
K
-------
L
T
P
L
Y
P
M
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
-
S
E
-
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
---
E
FG
K
R
I
H
L
N
S
R
FP
G
-
V
E
---
R
L
P
N
T
---
C
N
----
F
S
I
Q
G
SQ
L
R
G
Y
M
V
L
A
Q
C
Q
--
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
32
PsiBlast_CBE
71.36
32%
9
- C1 -
-
3A9X
2
SCLY_RAT
B:
[20-428]
---------------------------
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
--
A
M
K
E
A
W
G
N
P
-
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
--
S
T
V
R
C
F
H
E
Q
Q
T
L
Q
--------
T
R
P
--
H
---
F
I
T
C
T
V
-
E
H
D
S
I
R
L
P
L
E
H
L
V
-
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
---------
G
--
L
-
P
R
-
V
L
V
H
T
D
A
A
Q
A
L
G
K
RR
V
D
V
E
D
L
----
G
---
V
--
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
---
G
V
G
--
K
-------
L
T
P
L
Y
P
M
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
-
S
E
-
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
---
E
FG
K
R
I
H
L
N
S
R
FP
G
-
V
E
---
R
L
P
N
T
---
C
N
----
F
S
I
Q
G
SQ
L
R
G
Y
M
V
L
A
Q
C
Q
--
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
4
PsiBlast_PDB
71.23
38%
24
- C1 -
-
3LVK
1
ISCS_ECO57
A:
[22-386]
-------------------------
L
P
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
D
G
T
F
G
N
P
-
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
--
G
A
A
--------
N
F
Y
Q
---
K
K
G
K
----
H
---
I
I
T
S
K
T
-
E
H
K
A
V
L
D
T
C
R
Q
L
E
-
R
E
-
G
F
-
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
--
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
-------------------
R
--
A
-
R
G
-
I
I
Y
H
V
D
A
T
Q
S
V
G
K
--
L
P
I
D
--
L
S
Q
L
K
---
V
--
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
---
R
K
P
R
V
R
-------
I
E
A
Q
---
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
-
K
E
-
E
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
-
N
G
I
K
D
---
I
--
E
E
V
Y
L
N
G
D
--
L
-
E
H
---
G
A
P
N
I
---
L
N
----
V
S
F
N
Y
--
V
E
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
S
A
C
-----
L
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
-------------------
43
HHSearch
70.77
32%
-2
- C1 -
-
3VAX
1
?
A:
[22-379]
---------------------------
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
--
W
M
T
A
E
F
G
N
A
-
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
--
G
L
A
--------
P
Y
G
E
R
--
T
G
R
R
----
H
---
I
I
T
S
A
I
-
E
H
K
A
V
L
E
P
L
E
H
L
A
-
G
R
-
G
F
-
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
--
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
---------
R
---------
A
--
T
--
P
-
T
Y
L
H
V
D
A
A
Q
G
Y
G
K
--
V
P
G
D
-
L
T
-
T
-
P
---
I
--
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
---
R
R
E
--
E
MDDERVP
L
E
P
I
---
M
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
-
E
A
-
E
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
L
-
A
G
L
A
S
---
T
---
S
F
Q
V
N
G
D
--
Q
-
D
H
---
V
V
P
H
I
---
L
N
----
L
S
F
E
D
--
V
D
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
-
T
S
A
S
F
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
3
PsiBlast_PDB
70.72
38%
26
- C1 -
-
3LVJ
2
ISCS_ECO57
A:
[22-386]
-------------------------
L
P
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
D
G
T
F
G
N
P
-
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
--
G
A
A
--------
N
F
Y
Q
---
K
K
G
K
----
H
---
I
I
T
S
K
T
-
E
H
K
A
V
L
D
T
C
R
Q
L
E
-
R
E
-
G
F
-
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
--
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
-------------------
R
--
A
-
R
G
-
I
I
Y
H
V
D
A
T
Q
S
V
G
K
--
L
P
I
D
--
L
S
Q
L
K
---
V
--
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
---
R
K
P
R
V
R
-------
I
E
A
Q
---
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
-
K
E
-
E
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
-
N
G
I
K
D
---
I
--
E
E
V
Y
L
N
G
D
--
L
-
E
H
---
G
A
P
N
I
---
L
N
----
V
S
F
N
Y
--
V
E
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
-------
S
L
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
-------------------
13
PsiBlast_PDB
70.37
32%
11
- C1 -
-
3A9X
2
SCLY_RAT
A:
[20-428]
---------------------------
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
--
A
M
K
E
A
W
G
N
P
-
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
--
S
T
V
R
C
F
H
E
Q
Q
T
L
Q
G
-----
E
G
T
R
P
--
H
---
F
I
T
C
T
V
-
E
H
D
S
I
R
L
P
L
E
H
L
V
-
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
---------
G
--
L
-
P
R
-
V
L
V
H
T
D
A
A
Q
A
L
G
K
RR
V
D
V
E
D
L
----
G
---
V
--
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
---
G
V
G
--
K
-------
L
T
P
L
Y
P
M
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
-
S
E
-
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
---
E
FG
K
R
I
H
L
N
S
R
FP
G
-
V
E
---
R
L
P
N
T
---
C
N
----
F
S
I
Q
G
SQ
L
R
G
Y
M
V
L
A
Q
C
Q
--
T
L
L
A
S
V
G
A
-------------------
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
30
PsiBlast_CBE
69.85
32%
18
- C1 -
-
3A9Z
3
SCLY_RAT
B:
[20-428]
---------------------------
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
--
A
M
K
E
A
W
G
N
P
-
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
--
S
T
V
R
C
F
H
E
Q------------
T
R
P
--
H
---
F
I
T
C
T
V
-
E
H
D
S
I
R
L
P
L
E
H
L
V
-
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
---------
G
--
L
-
P
R
-
V
L
V
H
T
D
A
A
Q
A
L
G
K
RR
V
D
V
E
D
L
----
G
---
V
--
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
---
G
V
G
--
K
-------
L
T
P
L
Y
P
M
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
-
S
E
-
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
---
E
FG
K
R
I
H
L
N
S
R
FP
G
-
V
E
---
R
L
P
N
T
---
C
N
----
F
S
I
Q
G
SQ
L
R
G
Y
M
V
L
A
Q
C
Q
--
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
22
PsiBlast_CBE
69.76
38%
24
- C1 -
-
3LVJ
2
ISCS_ECO57
B:
[22-386]
-------------------------
L
P
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
FM
T
M
D
G
T
F
G
N
P
-
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
--
G
A
A
--------
N
F
Y
Q
---
K
K
G
K
----
H
---
I
I
T
S
K
T
-
E
H
K
A
V
L
D
T
C
R
Q
L
E
-
R
E
-
G
F
-
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
--
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
-------------------
R
--
A
-
R
G
-
I
I
Y
H
V
D
A
T
Q
S
V
G
K
--
L
P
I
D
--
L
S
Q
L
K
---
V
--
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
---
R
K
P
RV
R
-------
I
E
A
Q
---
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
-
K
E
-
E
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
-
N
G
I
K
D
---
I
--
E
E
V
Y
L
N
G
D
--
L
-
E
H
---
G
A
P
N
I
---
L
N
----
V
S
F
N
Y
--
V
E
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
S
A
C
-----
L
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
-------------------
12
PsiBlast_PDB
69.02
34%
-9
- C1 -
-
3VAX
1
?
A:
[22-375]
---------------------------
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
--
W
M
T
A
E
F
G
N
A
-
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
--
G
L
A
--------
P
Y
G
E
---
R
T
G
R
R---
H
---
I
I
T
S
A
I
-
E
H
K
A
V
L
E
P
L
E
H
L
A
-
G
R
-
G
F
-
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
--
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
---------
R
---------
A
--
T
-
P
T
--
Y
L
H
V
D
A
A
Q
G
Y
G
K
--
V
P
G
D
--
L
T
T
-
P
---
I
--
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
---
R
R
E
--
E
MDDERVP
L
E
P
I
---
M
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
-
E
A
-
E
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
L
-
A
G
L
A
S
---------
T
S
F
Q
V
--
N
-
G
D
QDH
V
V
P
H
I
---
L
N
----
L
S
F
E
D
--
V
D
A
E
A
F
L
V
T
L
K
D
-
L
V
A
V
A
T
G
S
A
S
-
T
S
A
S
F
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
------------------------------
29
PsiBlast_CBE
68.61
34%
-9
- C1 -
-
3VAX
2
?
B:
[22-375]
---------------------------
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
--
W
M
T
A
E
F
G
N
A
-
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
--
G
L
A
--------
P
Y
G
E
---
R
T
G
R
R---
H
---
I
I
T
S
A
I
-
E
H
K
A
V
L
E
P
L
E
H
L
A
-
G
R
-
G
F
-
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
--
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
---------
R
---------
A
--
T
-
P
T
--
Y
L
H
V
D
A
A
Q
G
Y
G
K
--
V
P
G
D
--
L
T
T
-
P
---
I
--
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
---
R
R
E
--
E
MDDERVP
L
E
P
I
---
M
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
-
E
A
-
E
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
L
-
A
G
L
A
S
---------
T
S
F
Q
V
--
N
-
G
D
QDH
V
V
P
H
I
---
L
N
----
L
S
F
E
D
--
V
D
A
E
A
F
L
V
T
L
K
D
-
L
V
A
V
A
T
G
S
A
S
-
T
S
A
S
F
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
------------------------------