@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U4D2: (2017-12-26 )
MIQLLRYAKDYRKQIILGPFFKFLEAVFELVLPLMMASLIDNGLKMNDRGKIIEMGLWMVAMSVIGLICAIICQYYASVASQGFGTELRNQLIKKINTFSHNELNHFGTDTLITRMTNDINQLQLALAMVIRLLIRAPFLSIGSVVMAFVIDWEVGLFFLALLPIFSIILFFIIKKTVPLYQKVQEKLDQLNEHVSQNLSGVRVIRAFAQTKKETEKFDKSTNDLANNYLRVSNISALLSPATTLIMNVGIICLLTVGGIKVNIGSLQQGQVLALINYMNQMLLALIVVSNLVVIFTRAEASGNRVKEVLDTENSILEAEVSTTPDFSSEAIIAFDHVDFRYTPDSGLSLQNITFQLKRNTVLGIIGPTGSGKTTLTQLIPRFYDVSSGTVIMDGMDVRSWQLDHLRQQIALVPQTSVLFTGTIRENLQWGKKDATEKECWEALKIAQAEEFVRQLPNGLDTKVMENGKNFSGGQKQRLTIARALIAKPALLILDDSLSALDYQTDLDLRKALQTYLGSTVIIISQRVRSIQEAHHILVMDQGKIAAQGTHEELLAQSAEYQEIVASQEEE
Atome Classification :
(39 SA)
---.........10........20........30........40---.......-------.---50------.........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.-......270.......280.......290.......300.......310.......320--.-.......330.......340...------.-...350........360.......370.......380.......390.......400--.......410.......420-......--------.430---..---.---....-440.......450.......460.......470.......480.......490........500---..---..-...510.-....-..--520.......530.-......540.......550......-.560.......570
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---M
I
Q
L
L
R
Y
A
K
D
Y
R
K
QI
I
L
G
P
F
F
K
F
L
E
A
V
F
E
L
V
L
P
L
M
M
A
S
L
I
D---NGLKMND-------R---G-------
K
I
I
E
M
G
L
W
M
V
A
M
S
V
I
G
L
I
C
A
I
I
C
Q
Y
Y
A
S
V
A
SQGF
G
T
E
L
R
N
Q
L
I
K
K
I
NTFSH
N
E
L
N
HFG
T
D
T
L
I
T
R
M
TN
D
I
N
Q
L
Q
L
A
L
A
M
V
I
R
L
L
I
RA
P
F
L
S
I
G
S
V
V
M
A
F
VIDW
E
V
G
L
F
F
L
A
L
L
P
I
F
S
I
I
L
F
F
I
I
K
KT
V
P
L
Y
Q
K
V
Q
E
K
L
D
Q
L
N
E
H
V
S
Q
NL
S
G
V
R
V
I
R
A
F
A
Q
T
K
K
E
T
E
K
FDK
S
T
N
D
L
A
N
N
Y
L
R
V
S
N
I
S
A
L
L
S
P
A
T
T
L
I
M
NV
G
I
I
C
L
L
T
VG
G
I
K
V
N-IGSLQQG
Q
V
L
A
L
I
N
Y
M
N
Q
M
L
L
A
L
I
V
V
S
N
L
V
V
I
F
T
RAEASG
N
R
V
K
E
V
LDTEN
S
I
L
E
A
EV---S-TTPDFSS
E
A
I
I
A
F
DH
V
D
F
R
YTPD------S-G
L
S
L
-
Q
N
I
T
F
Q
L
KR
N
T
V
L
G
I
IGPTGS
G
K
T
T
L
T
Q
L
I
P
R
F
YDVSS
G
T
V
I
M
DGMDVR
S
W
Q
--
L
D
H
L
R
Q
Q
I
ALVPQ
T
S
V
L
F
T
G
-
T
I
R
E
NL--------QWGK---KD---A---
T
E
K
E
-
C
W
E
A
L
K
I
A
Q
A
E
E
F
V
R
QLPNGL
D
T
K
V
M
ENGKNFSGG
Q
K
Q
R
L
T
I
A
R
A
L
IAK
P
A
-
L
L
I
LDDSLSALD---YQ---T
D
-
L
D
L
R
K
A
L
-
Q
T
YL-G
S
--
T
V
I
I
I
S
Q
R
V
R
S
I
Q
E-A
H
H
I
L
V
M
DQG
K
I
AAQG
T
H
E
E
L
L
A
Q
S
-
A
E
Y
Q
E
I
V
ASQEEE
100
HHSearch
83.71
40%
-
- C2 -
-
4Q4H
-
?
A:
[2-568]
----
K
T
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
---
E
G
I
A
R
G
D
-------
F
---
S
-------
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
-
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
---
A
--
L
A
L
P
N
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
N
------
T
-
D
P
V
L
-
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
--
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
L
--------
K
W
G
R
---
E
D
---
A
---
T
D
D
E
-
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
L
I
L
D
D
C
T
S
S
V
D
---
P
I
---
T
E
-
K
R
I
L
D
G
L
-
K
R
Y
T
K
G
C
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
-
K
P
Y
R
E
I
Y
E
S
Q
---
3
PsiBlast_PDB
82.23
39%
-
- C2 -
-
4Q4H
-
?
A:
[4-568]
------
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
---
E
G
I
A
R
G
D
-------
F
---
S
-------
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
-
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
---
A
L
A
L
P
N
V
--
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
N
------
T
-
D
P
V
L
-
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
--
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
L
--------
K
W
G
R
---
E
D
---
A
---
T
D
D
E
-
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
L
I
L
D
D
C
T
S
S
V
D
---
P
I
---
T
E
-
K
R
I
L
D
G
L
-
K
R
Y
T
K
G
C
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
-
K
P
Y
R
E
I
Y
E
S
Q
---
1
PsiBlast_PDB
82.05
39%
-60
- C2 -
-
3QF4
1
?
A:
[14-578]
------
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
---
E
G
I
A
R
G
D
-------
F
---
S
-------
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
-
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
---
A
L
A
L
P
N
V
--
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
N
------
T
-
D
P
V
L
-
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
--
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
L
--------
K
W
G
R
---
E
D
---
A
---
T
D
D
E
-
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
L
I
L
D
D
C
T
S
S
V
D
---
P
I
---
T
E
-
K
R
I
L
D
G
L
-
K
R
Y
T
K
G
C
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
-
K
P
Y
R
E
I
Y
E
S
Q
---
2
PsiBlast_PDB
81.16
39%
-59
- C2 -
-
4Q4A
1
?
A:
[14-578]
------
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
---
E
G
I
A
R
G
D
-------
F
---
S
-------
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
-
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
---
A
L
A
L
P
N
V
--
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
N
------
T
-
D
P
V
L
-
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
--
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
L
--------
K
W
G
R
---
E
D
---
A
---
T
D
D
E
-
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
L
I
L
D
D
C
T
S
S
V
D
---
P
I
---
T
E
-
K
R
I
L
D
G
L
-
K
R
Y
T
K
G
C
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
-
K
P
Y
R
E
I
Y
E
S
Q
---
4
PsiBlast_PDB
79.99
40%
-51
- C2 -
-
4Q4J
-
?
A:
[4-568]
------
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
S
D
L
S
Q
P
T
L
L
A
R
I
V
D
---
E
G
I
A
R
G
D
-------
F
---
S
-------
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
S
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
-
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
---
A
L
A
L
P
N
V
--
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
N
------
T
-
D
P
V
L
-
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
--
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
L
--------
K
W
G
R
---
E
D
---
A
---
T
D
D
E
-
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
L
I
L
D
D
S
T
C
S
V
D
---
P
I
---
T
E
-
K
R
I
L
D
G
L
-
K
R
Y
T
K
G
S
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
S
-
K
P
Y
R
E
I
Y
E
S
Q
---
22
PsiBlast_CBE
68.84
31%
-125
- C2 -
-
3QF4
1
Y288_THEMA
B:
[105-590]
-------------------------------------------------------------------------------------------------------
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
-
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
---
V
-
E
L
R
E
V
R
G
E
--
I
E
F
K
N
V
W
F
S
Y
D
K
K
------
K
-
P
V
-
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
--
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
L
--------
K
Y
G
N
---
P
G
---
A
---
T
D
E
E
-
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
---
T
K
---
T
E
-
K
S
I
Q
A
A
M
-
W
K
L
M
E
G
K
--
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
-
G
F
Y
Y
E
L
F
T
S
Q
---
21
PsiBlast_CBE
68.43
31%
-126
- C2 -
-
4Q4A
1
Y288_THEMA
B:
[105-590]
-------------------------------------------------------------------------------------------------------
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
-
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
---
V
-
E
L
R
E
V
R
G
E
--
I
E
F
K
N
V
W
F
S
Y
D
K
K
------
K
-
P
V
-
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
--
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
L
--------
K
Y
G
N
---
P
G
---
A
---
T
D
E
E
-
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
---
T
K
---
T
E
-
K
S
I
Q
A
A
M
-
W
K
L
M
E
G
K
--
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
-
G
F
Y
Y
E
L
F
T
S
Q
---
99
HHSearch
67.25
25%
-61
- C2 -
-
5MKK
-
?
B:
[10-570]
----
R
R
L
W
P
Y
V
G
R
Y
R
W
R
Y
L
W
A
V
L
A
G
L
V
S
I
F
F
F
V
L
T
P
Y
F
L
R
L
A
V
D
---
A
V
Q
A
G
R
G
--------------------
F
G
V
Y
A
L
A
I
V
A
S
A
A
L
S
G
L
L
S
Y
A
M
R
R
L
A
V
V
A
S
R
Q
V
E
Y
D
L
R
R
D
L
L
H
H
L
L
T
L
D
R
D
F
Y
H
K
H
R
V
G
D
L
M
N
R
L
N
T
D
L
S
A
V
R
E
M
V
G
P
G
I
L
M
G
S
R
L
S
F
L
V
L
L
A
F
L
S
M
Y
A
V
N
A
R
L
A
F
Y
L
T
L
I
L
P
G
I
F
L
A
M
R
F
L
L
R
L
I
D
R
R
Y
R
E
A
Q
E
V
F
D
R
I
S
T
L
A
Q
E
A
F
S
G
I
R
V
V
K
G
Y
A
L
E
R
R
M
V
A
W
F
Q
D
L
N
R
L
Y
V
E
K
S
L
A
L
A
R
V
E
G
P
L
H
A
L
L
G
F
L
M
G
F
A
F
L
T
V
L
W
A
G
G
A
M
-
V
V
R
G
E
L
S
V
G
E
L
V
Q
F
N
A
Y
L
A
Q
L
T
W
P
I
L
G
L
G
W
V
M
A
L
Y
Q
R
G
L
T
S
L
R
R
L
F
E
L
L
D
E
K
P
A
I
R
D
E
D
P
---
L
-
P
L
A
L
E
D
L
S
G
E
V
R
F
E
G
V
G
L
K
R
D
G
---------
R
W
L
L
-
R
G
L
T
L
T
I
P
E
G
M
T
L
G
I
T
G
R
T
G
S
G
K
S
L
L
A
A
L
V
P
R
L
L
D
P
S
E
G
R
V
Y
V
G
G
H
E
A
R
R
I
P
--
L
A
V
L
R
K
A
V
G
V
A
P
Q
E
P
F
L
F
S
E
-
T
I
L
E
N
I
--------
A
F
G
L
---
D
E
---
V
---
D
R
E
R
-
V
E
W
A
A
R
L
A
G
I
H
E
E
I
L
A
F
P
K
G
Y
E
T
V
L
G
E
R
G
I
T
L
S
G
G
Q
R
Q
R
V
A
L
A
R
A
L
A
K
R
P
K
-
I
L
I
L
D
D
A
L
S
A
V
D
---
A
E
---
T
E
-
A
R
I
L
Q
G
L
-
K
T
V
L
G
K
Q
--
T
T
L
L
I
S
H
R
T
A
A
L
R
H
-
A
D
W
I
I
V
L
D
G
G
R
I
V
E
E
G
T
H
E
S
L
L
Q
A
G
-
G
L
Y
A
E
M
D
R
-----
109
HHSearch
66.46
28%
-44
- C2 -
-
5MKK
-
?
A:
[15-588]
----
A
R
I
L
R
Y
V
W
P
Y
R
L
Q
V
V
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
W
A
I
D
---
L
A
L
V
P
T
E
PR
P
L
A
E
R
F
---
H
-------
L
L
L
W
I
S
L
G
F
L
A
V
R
A
V
H
F
A
A
T
Y
G
E
T
Y
L
I
Q
W
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
N
P
V
G
R
L
M
T
R
V
T
S
D
V
D
A
I
N
Q
F
I
T
G
G
L
V
G
V
I
A
D
L
F
T
L
V
G
L
L
G
F
M
L
F
L
S
P
K
L
T
L
V
V
L
L
V
A
P
V
L
L
A
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
E
M
R
L
R
L
A
R
V
N
A
A
L
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
D
R
L
N
R
D
L
F
R
A
W
V
E
I
I
R
W
F
A
L
F
F
P
V
V
G
F
L
G
D
F
A
V
A
S
L
V
Y
Y
G
G
G
E
-
V
V
R
G
A
V
S
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
Q
P
L
Q
D
L
S
D
K
F
N
L
F
Q
G
A
M
A
S
A
E
R
I
F
G
V
L
D
T
E
E
E
L
K
D
P
E
D
---
P
--
T
P
I
R
G
F
R
G
E
V
E
F
R
D
V
W
L
A
Y
T
P
K
GVEPTE
K
-
D
W
V
L
-
K
G
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
D
P
Q
R
G
C
V
F
L
D
G
V
D
V
R
R
Y
R
--
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
L
F
S
G
-
T
V
L
D
N
L
--------
R
L
F
D
---
P
S
---
V
---
P
P
E
R
-
V
E
E
V
A
R
F
L
G
A
H
E
F
I
L
R
L
P
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
I
L
L
I
L
D
E
A
T
A
S
V
D
---
S
E
---
T
E
-
K
R
L
Q
E
A
L
-
Y
K
A
M
E
G
R
--
T
S
L
I
I
A
H
R
L
S
T
I
R
H
-
V
D
R
I
L
V
F
R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
A
K
G
-
G
Y
Y
----------
104
HHSearch
65.63
29%
-57
- C2 -
-
3QF4
1
Y288_THEMA
B:
[26-590]
----
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
---
V
V
F
V
P
R
R
-------
F
---
D
-------
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
-
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
------
V
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
D
K
K
--------
K
P
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
--
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
L
--------
K
Y
G
N
---
P
G
---
A
---
T
D
E
E
-
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
---
T
K
---
T
E
-
K
S
I
Q
A
A
M
-
W
K
L
M
E
G
K
--
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
-
G
F
Y
Y
E
L
F
T
S
Q
---
103
HHSearch
64.71
29%
-
- C2 -
-
4Q4H
-
Y288_THEMA
B:
[26-590]
----
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
---
V
V
F
V
P
R
R
-------
F
---
D
-------
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
-
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
------
V
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
D
K
K
--------
K
P
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
--
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
L
--------
K
Y
G
N
---
P
G
---
A
---
T
D
E
E
-
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
---
T
K
---
T
E
-
K
S
I
Q
A
A
M
-
W
K
L
M
E
G
K
--
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
-
G
F
Y
Y
E
L
F
T
S
Q
---
94
HHSearch
63.94
28%
-33
- C2 -
-
4AYX
6
ABCBA_HUMAN
A:
[8-574]
----
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
---
V
I
Y
T
N
P
T
-------
V
DY
S
D
-------
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
-
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
---
V
-
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
------
P
E
V
P
I
F
-
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
--
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
--------
A
Y
G
A
---
D
D
PSS
V
---
T
A
E
E
-
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
---
A
E
---
N
E
-
Y
L
V
Q
E
A
L
-
D
R
L
M
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
G
------------
15
PsiBlast_PDB
62.05
27%
-25
- C2 -
-
4AYX
6
ABCBA_HUMAN
A:
[9-571]
-----
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
Y
-------
S
---
D
-------
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
-
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
---
V
-
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
------
P
-
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
--
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
--------
A
Y
G
A
---
D
D
---
P
SSV
T
A
E
E
-
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
---
A
E
---
N
E
-
Y
L
V
Q
E
A
L
-
D
R
L
M
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
---------------
113
Fugue
61.66
27%
-35
- C2 -
-
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
---
D
G
F
G
K
T
D
-------
R
---
S
-------
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
---
E
K
D
E
---
G
-
K
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
------
E
-
V
P
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
--
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
I
--------
A
Y
A
R
---
T
E
---
E
Y--
S
R
E
Q
-
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
---
T
E
---
S
E
-
R
A
I
Q
A
A
L
-
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
-
11
PsiBlast_PDB
61.63
27%
-
- C2 -
-
3B5W
-
MSBA_ECOLI
A:
[23-575]
-------------
F
K
A
G
L
I
V
A
G
V
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
---
D
G
F
G
K
T
D
-------
R
---
S
-------
V
L
V
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
V
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
S
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
I
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
N
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
R
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
T
I
L
D
S
E
Q
E
K
D
E
G
K
R
V
I
E
R
-
A
T
G
D
------
V
E
F
R
N
V
T
F
T
Y
P
G
R
------
D
-
V
P
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
E
I
L
M
D
G
H
D
L
R
E
Y
T
--
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
I
--------
A
Y
A
R
---
T
E
---
Q
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
V
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
---
T
E
---
S
E
-
R
A
I
Q
A
A
L
D
E
L
Q
K
-
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
K
-
A
D
E
I
V
V
V
E
D
G
V
I
V
E
R
G
T
H
N
D
L
L
E
H
R
-
G
V
Y
A
Q
L
-------
93
HHSearch
61.46
28%
-38
- C2 -
-
4AYT
7
ABCBA_HUMAN
A:
[8-567]
----
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
---
V
I
Y
T
N
P
T
-------
V
DY
S
D
-------
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
-
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
---
V
-
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
------
P
E
V
P
I
F
-
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
--
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
--------
A
Y
G
A
---
D
D
PSS
V
---
T
A
E
E
-
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
---
A
E
---
N
E
-
Y
L
V
Q
E
A
L
-
D
R
L
M
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------
98
HHSearch
61.22
27%
-30
- C2 -
-
4A82
-
Y1866_STAAM
B:
[3-576]
----
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
---
G
V
I
N
N
H
A
-------
L
---
T
TDEKVHH
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
-
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
G
---
A
--
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
------
E
-
A
P
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
--
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
I
--------
L
L
G
R
---
P
T
---
A
---
T
D
E
E
-
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
---
L
E
---
S
E
-
S
I
I
Q
E
A
L
-
D
V
L
S
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
-
G
A
Y
E
H
L
Y
S
I
Q
---
9
PsiBlast_PDB
61.05
28%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
A:
[23-575]
-------------
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
---
D
G
F
G
K
T
D
-------
R
---
S
-------
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
R
V
I
D
R
-
A
T
G
D
------
L
E
F
R
N
V
T
F
T
Y
P
G
R
------
E
-
V
P
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
--
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
I
--------
A
Y
A
R
---
T
E
---
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
---
T
E
---
S
E
-
R
A
I
Q
A
A
L
D
E
L
Q
K
-
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
-
G
V
Y
A
Q
L
-------
8
PsiBlast_PDB
61.05
28%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
A:
[23-575]
-------------
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
---
D
G
F
G
K
T
D
-------
R
---
S
-------
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
R
VID
R
-
A
T
G
D
------
L
E
F
R
N
V
T
F
T
Y
P
G
R
------
E
-
V
P
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
--
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
I
--------
A
Y
A
R
---
T
E
---
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
---
T
E
---
S
E
-
R
A
I
Q
A
A
L
D
E
L
Q
K
-
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
-
G
V
Y
A
Q
L
-------
17
PsiBlast_PDB
59.73
27%
-24
- C2 -
-
4AYW
3
ABCBA_HUMAN
A:
[40-598]
-----
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
Y
-------
S
---
D
-------
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
-
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
---
V
-
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
------
P
-
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
--
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
--------
A
Y
G
A
---
D
D
---
P
SSV
T
A
E
E
-
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
----
L
D
---
A
E
---
N
E
-
Y
L
V
Q
E
A
L
-
D
R
L
M
D
G
R
--
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------
27
PsiBlast_CBE
48.90
41%
-125
- C2 -
-
2FGJ
2
D:
[8-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
------
S
-
P
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
--------
S
L
A
N
---
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
---
Y
E
---
S
E
H
V
I
M
R
N
M
H
-
K
I
C
K
-
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
---------------
35
PsiBlast_CBE
48.71
41%
-130
- C2 -
-
1XEF
2
HLYBP_ECOLX
A:
[2-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
------
S
-
P
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
--------
S
L
A
N
---
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
---
Y
E
---
S
E
H
V
I
M
R
N
M
H
-
K
I
C
K
-
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
---------------
28
PsiBlast_CBE
48.68
41%
-124
- C2 -
-
2FGJ
2
HLYBP_ECOLX
C:
[8-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
------
S
-
P
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
--------
S
L
A
N
---
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
---
Y
E
---
S
E
H
V
I
M
R
N
M
H
-
K
I
C
K
-
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
---------------
37
PsiBlast_CBE
47.99
41%
-125
- C2 -
-
2FGK
2
D:
[8-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
------
S
-
P
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
--------
S
L
A
N
---
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
Q
A
T
S
A
L
D
---
Y
E
---
S
E
H
V
I
M
R
N
M
H
-
K
I
C
K
-
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
---------------
40
PsiBlast_CBE
47.86
41%
-119
- C2 -
-
2FGK
2
HLYBP_ECOLX
A:
[8-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
------
S
-
P
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
--------
S
L
A
N
---
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
Q
A
T
S
A
L
D
---
Y
E
---
S
E
H
V
I
M
R
N
M
H
-
K
I
C
K
-
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
---------------
30
PsiBlast_CBE
47.56
41%
-125
- C2 -
-
2FGJ
2
HLYBP_ECOLX
A:
[8-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
------
S
-
P
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
--------
S
L
A
N
---
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
---
Y
E
---
S
E
H
V
I
M
R
N
M
H
-
K
I
C
K
-
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
---------------
39
PsiBlast_CBE
47.48
41%
-125
- C2 -
-
2FGK
2
HLYBP_ECOLX
B:
[8-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
------
S
-
P
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
--------
S
L
A
N
---
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
Q
A
T
S
A
L
D
---
Y
E
---
S
E
H
V
I
M
R
N
M
H
-
K
I
C
K
-
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
---------------
38
PsiBlast_CBE
47.10
41%
-119
- C2 -
-
2FGK
2
HLYBP_ECOLX
C:
[8-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
------
S
-
P
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
--------
S
L
A
N
---
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
Q
A
T
S
A
L
D
---
Y
E
---
S
E
H
V
I
M
R
N
M
H
-
K
I
C
K
-
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
---------------
36
PsiBlast_CBE
46.85
41%
-134
- C2 -
-
3B5J
1
A:
[4-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
------
S
-
P
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
--------
S
L
A
N
---
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
---
Y
E
---
S
E
H
V
I
M
R
N
M
H
-
K
I
C
K
-
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
---------------
26
PsiBlast_CBE
46.69
41%
-134
- C2 -
-
2PMK
1
A:
[4-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
------
S
-
P
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
--------
S
L
A
N
---
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
---
Y
E
---
S
E
H
V
I
M
R
N
M
H
-
K
I
C
K
-
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
---------------
31
PsiBlast_CBE
45.60
41%
-128
- C2 -
-
2FFA
2
A:
[8-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
------
S
-
P
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
--------
S
L
A
N
---
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
---
Y
E
---
S
E
H
V
I
M
R
N
M
H
-
K
I
C
K
-
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
---------------
24
PsiBlast_CBE
44.82
41%
-128
- C2 -
-
2FF7
1
A:
[8-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
------
S
-
P
V
I
L
-
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
--------
S
L
A
N
---
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
---
Y
E
---
S
E
H
V
I
M
R
N
M
H
-
K
I
C
K
-
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
---------------
49
PsiBlast_CBE
42.05
38%
-117
- C2 -
-
5DGX
1
A:
[34-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
E
G
E
I
L
L
D
G
V
D
T
R
E
L
T
--
L
E
N
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
D
D
-
T
V
Y
N
N
I
--------
A
F
G
-----
E
---
V
---
S
E
E
E
-
V
I
D
A
L
K
R
A
N
A
Y
E
F
V
Q
E
L
S
D
G
I
N
T
N
I
G
N
N
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
-
V
L
I
F
D
E
-----------------------
L
-
E
S
L
T
-
K
S
C-
T
T
I
V
I
A
H
R
L
S
T
V
E
N
-
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
G
-
G
L
Y
T
R
L
Y
Q
S
----
79
PsiBlast_CBE
32.35
35%
-42
- C2 -
-
5L22
2
?
B:
[349-549]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
R
N
I
N
M
R
I
L
P
G
E
F
V
A
I
I
G
P
S
G
S
G
K
S
S
L
V
R
T
I
L
G
I
W
L
P
V
H
G
T
V
E
I
D
G
A
D
L
K
Q
W
D
--
R
D
Y
F
G
K
F
V
G
Y
L
P
Q
D
I
E
L
F
E
G
-
T
V
A
E
N
I
A
-------
R
F
G
E
---
L
D
---
S
-----
E
K
-
I
I
E
A
A
K
L
S
G
A
H
D
V
I
I
K
L
P
D
G
Y
D
T
Y
I
G
P
G
G
I
T
L
S
G
G
Q
R
Q
R
I
A
L
A
R
A
L
Y
G
N
P
R
-
I
V
I
L
D
E
P
D
S
N
L
D
---
E
Q
---
G
E
-
Q
A
L
Y
N
A
L
-
I
E
L
K
-
K
R
KV
T
T
I
I
V
S
H
R
I
R
L
L
N
L
-
V
D
K
I
A
I
M
Q
D
G
T
L
K
A
F
G
-----------------------
80
PsiBlast_CBE
30.60
35%
-41
- C2 -
-
5L22
2
?
A:
[349-549]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
R
N
I
N
M
R
I
L
P
G
E
F
V
A
I
I
G
P
S
G
S
G
K
S
S
L
V
R
T
I
L
G
I
W
L
P
V
H
G
T
V
E
I
D
G
A
D
L
K
Q
W
D
--
R
D
Y
F
G
K
F
V
G
Y
L
P
Q
D
I
E
L
F
E
G
-
T
V
A
E
N
I
A
-------
R
F
G
E
---
L
D
---
S
-----
E
K
-
I
I
E
A
A
K
L
S
G
A
H
D
V
I
I
K
L
P
D
G
Y
D
T
Y
I
G
P
G
G
I
T
L
S
G
G
Q
R
Q
R
I
A
L
A
R
A
L
Y
G
N
P
R
-
I
V
I
L
D
E
P
D
S
N
L
D
---
E
Q
---
G
E
-
Q
A
L
Y
N
A
L
-
I
E
L
K
-
K
R
KV
T
T
I
I
V
S
H
R
I
R
L
L
N
L
-
V
D
K
I
A
I
M
Q
D
G
T
L
K
A
F
G
-----------------------
87
PsiBlast_CBE
27.73
31%
4
- C2 -
-
4U00
1
?
A:
[20-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
D
R
A-
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
---
E
K
---
A
----
E
K
K
-
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
-----------
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
-
A
Q
G
--
G
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
-
K
E
-----------
90
PsiBlast_CBE
27.42
31%
-15
- C2 -
-
4YMU
1
?
J:
[17-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
VN
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--------
T
L
A
P
VKV
K
K
---
M
---
N
K
K
E
-
A
E
E
L
-----
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
-
V
M
L
F
D
E
P
T
S
A
L
D
PEM
V
K
---
E
V
-
L
N
V
M
K
Q
L
-
A
N
E
--
G
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
--------------
91
PsiBlast_CBE
27.37
31%
-17
- C2 -
-
4YMU
1
?
A:
[17-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
VN
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--------
T
L
A
P
VKV
K
K
---
M
---
N
K
K
E
-
A
E
E
L
-----
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
-
V
M
L
F
D
E
P
T
S
A
L
D
PEM
V
K
---
E
V
-
L
N
V
M
K
Q
L
-
A
N
E
--
G
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
--------------
89
PsiBlast_CBE
26.56
31%
-20
- C2 -
-
4YMV
1
?
A:
[17-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
VN
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--------
T
L
A
P
VKV
K
K
---
M
---
N
K
K
E
-
A
E
E
L
-----
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
-
V
M
L
F
D
E
P
T
S
A
L
D
PEM
V
K
---
E
V
-
L
N
V
M
K
Q
L
-
A
N
E
--
G
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
--------------