@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U577: (2017-12-28 )
MTQEQQHQVEDLNDQMLVRRQKMEQLREDGIDPFGKRFERTHNSEELHELFDPRTKEELAEMGLTASVAGRMMTRRGKGKAGFAHLQDREGQIQIYVRKDQVGDEAYEVFKHADLGDFFGVTGQIMKTDTGEVSIKASEITILSKALRPLPDKYHGLTNIEQRYRQRYLDLISNRESFDRFMKRSQIISEIRRYLDGNGYIEVETPVLHNEAGGAAARPFITHHNALDIDLYLRIALELHLKRLIVGGMEKVYEIGRVFRNEGIDTTHNPEFTMLEAYTAYTDFNDVMNLTEGIIRNAAEKVLGTAKITYDGQAVDLESDFKRIHMVDAIKEQTGVDFWQEMTLEEALALAEKHNVEVTEAMGVGHVINEFFETFVEETLTQPTFVYGHPVEVSPLAKKNPEDPRFTDRFELFIVGREFANAFTELNDPIDQRERFEAQEKERELGNDEAHGVDEDFLEALEYGMPPTGGLGIGIDRLVMLLTDAQSIRDVLLFPTMR
Atome Classification :
(34 SA)
.........10........20.-.......30........40........50........60--........70........-80-........90........100.-.-...-.-------.110..----.....120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.-....-..310---.-------...--.....320.......330-.....------..340..------......-350---.--.......360--.----........370.......380.---......390.......400------.......410.......420.......430--------.....--------------------------..440.......450.......460.......470.......480.......490......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
Q
E
Q
Q
H
Q
V
E
DL
N
D
Q
M
L
V
R
R
Q
K
-
M
E
Q
L
R
EDGI
D
P
F
G
K
R
F
E
RTH
N
S
E
E
L
H
E
LFDPR
T
K
E
E
L
A
E--MG
L
T
A
S
V
A
G
R
M
M
T
RRGKG-KA-GF
A
H
LQDREG
Q
I
Q
I
Y
V
RKDQVG-
D
-
E
A
Y
-
E
-------
V
F
KHAD----
L
G
D
F
FGVT
G
Q
I
M
KTDT
G
E
V
S
I
K
A
S
E
I
T
I
L
S
K
A
L
RPL
P
D
K
YHGL
T
N
I
E
Q
R
Y
R
Q
R
Y
L
D
L
ISN
R
E
S
F
D
R
F
M
K
R
S
Q
I
I
S
E
I
R
R
Y
LDGN
G
Y
I
E
V
ET
P
V
L
HNEAGGAAAR
P
F
ITHHNALD
I
D
L
Y
L
R
I
A
L
E
L
H
L
K
R
L
I
V
G
G
M
E
K
V
Y
E
I
G
R
V
F
R
NEGIDTTHNPE
F
T
M
L
E
A
Y
TAYT
D
F
N
D
V
M
N
L
T
E
G
I
I
R
N
A
A
E
K
VL-G
T
A
K
-
I
T
Y-----D-------G
Q
A
--V
D
L
E
S
D
F
K
R
I
H
M
V
D
A
I
K
E
-
Q
T
G
V
D
------
F
W
Q
E
-
M
T
------
L
E
E
A
L
A
-
L
A
----
E
--KHN
V
E
V
T
E
----A----MG
V
G
H
V
I
N
E
F
F
E
T
F
V
E
E
TLTQ
P
---
T
F
VYGHPVEVSPLAKKNPE------DPRFT
D
R
F
E
L
F
I
V
G
R
E
F
A
N
A
F
T
ELNDP
I
D
Q
--------
R
E
R
F
E
--------------------------
A
Q
E
K
E
R
ELGNDEAHGV
D
E
D
F
L
E
A
L
EYGMPPTGGL
G
I
G
I
D
R
L
V
M
L
LT
D
A
Q
S
I
R
D
V
LLFPTMR
24
PsiBlast_CBE
95.44
70%
-82
- C7 -
-
3E9H
1
SYK_GEOSE
D:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
102
HHSearch
95.30
70%
-81
- C7 -
-
3E9H
1
SYK_GEOSE
B:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
26
PsiBlast_CBE
95.30
70%
-81
- C7 -
-
3E9H
1
SYK_GEOSE
B:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
27
PsiBlast_CBE
95.29
70%
-83
- C7 -
-
3A74
2
SYK_GEOSE
D:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
29
PsiBlast_CBE
95.09
70%
-82
- C7 -
-
3A74
2
SYK_GEOSE
B:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
1
PsiBlast_PDB
95.06
70%
-81
- C7 -
-
3E9H
1
SYK_GEOSE
A:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
22
PsiBlast_CBE
94.56
70%
-84
- C7 -
-
3E9I
3
SYK_GEOSE
C:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
21
PsiBlast_CBE
94.54
70%
-83
- C7 -
-
3E9I
3
SYK_GEOSE
D:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
103
HHSearch
94.44
70%
-83
- C7 -
-
3A74
2
SYK_GEOSE
A:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
3
PsiBlast_PDB
94.44
70%
-83
- C7 -
-
3A74
2
SYK_GEOSE
A:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
28
PsiBlast_CBE
94.43
70%
-83
- C7 -
-
3A74
2
SYK_GEOSE
C:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
25
PsiBlast_CBE
94.32
70%
-83
- C7 -
-
3E9H
1
SYK_GEOSE
C:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
2
PsiBlast_PDB
94.14
70%
-81
- C7 -
-
3E9I
3
SYK_GEOSE
A:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
23
PsiBlast_CBE
93.57
70%
-79
- C7 -
-
3E9I
3
SYK_GEOSE
B:
[4-491]
----------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
--
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
G
-
E
-
Q
Q
Y
-
E
-------
L
F
K
I
S
D
----
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
-
I
Q
Y
-----
G
-------
E
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
-
Y
V
G
V
D
------
F
W
R
Q
-
M
S
------
D
E
E
A
R
E
-
L
A
----
K
--
E
H
G
V
E
V
A
P
----
H
----
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
94
HHSearch
78.61
48%
-38
- C7 -
-
4EX5
1
SYK_BURTA
B:
[35-526]
----------
D
E
N
Q
I
V
A
E
R
R
D
K
-
L
R
A
L
R
D
Q
G
I
-
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
A
--
K
S
L
E
V
A
I
A
G
R
M
M
L
K
R
V
M
G
-
K
A
-
S
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
T
P
A
D
V
G
-
A
-
E
T
Y
-
D
-------
A
F
K
K
W
D
----
L
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
-------
D
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
-
G
T
A
T
-
I
Q
Y
-----
Q
-------
G
R
E
--
L
D
L
A
Q
P
F
H
R
L
T
I
T
Q
A
I
Q
K
-
Y
A
P
S
Y
------
T
D
G
Q
L
S
D
------
D
A
F
L
R
S
-
E
L
----
K
--
R
L
G
V
D
V
T
Q
PAFL
N
----
A
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
---
T
F
I
I
D
Y
P
I
E
V
S
P
L
A
R
E
S
D
T
------
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
--------
A
A
R
F
K
--------------------------
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
30
PsiBlast_CBE
78.11
51%
1
- C7 -
-
1LYL
1
SYK2_ECOLI
C:
[14-501]
-----------
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
--
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
P
-
E
-
G
V
Y
N
D
-------
Q
F
K
K
W
D
----
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
D
L
-
D
N
------
F
D
A
A
K
A
-
L
A
----
E
--
S
I
G
I
T
V
E
K
----
S
----
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
11
PsiBlast_PDB
77.95
48%
-44
- C7 -
-
4EX5
1
SYK_BURTA
A:
[36-526]
-----------
E
N
Q
I
V
A
E
R
R
D
K
-
L
R
A
L
R
D
Q
G
I
-
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
A
--
K
S
L
E
V
A
I
A
G
R
M
M
L
K
R
V
M
G
-
K
A
-
S
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
T
P
A
D
V
G
-
A
-
E
T
Y
-
D
-------
A
F
K
K
W
D
----
L
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
------
D
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
-
G
T
A
T
-
I
Q
Y
-----
Q
-------
G
R
E
--
L
D
L
A
Q
P
F
H
R
L
T
I
T
Q
A
I
-
Q
-
K
Y
A
P
S
------
Y
T
D
G
-
Q
L
------
S
D
D
A
F
L
-
R
S
----
E
L
K
R
L
G
V
D
V
T
Q
----
P
AFLN
A
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
---
T
F
I
I
D
Y
P
I
E
V
S
P
L
A
R
E
S
D
T
------
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
--------
A
A
R
F
K
--------------------------
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
6
PsiBlast_PDB
77.90
51%
6
- C7 -
-
1LYL
1
SYK2_ECOLI
A:
[14-501]
-----------
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
--
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
P
-
E
-
G
V
Y
N
D
-------
Q
F
K
K
W
D
----
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
D
L
-
D
N
------
F
D
A
A
K
A
-
L
A
----
E
--
S
I
G
I
T
V
E
K
----
S
----
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
31
PsiBlast_CBE
77.78
51%
3
- C7 -
-
1LYL
1
SYK2_ECOLI
B:
[14-501]
-----------
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
--
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
P
-
E
-
G
V
Y
N
D
-------
Q
F
K
K
W
D
----
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
D
L
-
D
N
------
F
D
A
A
K
A
-
L
A
----
E
--
S
I
G
I
T
V
E
K
----
S
----
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
32
PsiBlast_CBE
77.46
48%
-42
- C7 -
-
4EX5
1
SYK_BURTA
B:
[35-526]
----------
D
E
N
Q
I
V
A
E
R
R
D
K
-
L
R
A
L
R
D
Q
G
I
-
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
A
--
K
S
L
E
V
A
I
A
G
R
M
M
L
K
R
V
M
G
-
K
A
-
S
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
T
P
A
D
V
G
-
A
-
E
T
Y
-
D
-------
A
F
K
K
W
D
----
L
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
-------
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
-
G
T
A
T
-
I
Q
Y
-----
Q
-------
G
R
E
--
L
D
L
A
Q
P
F
H
R
L
T
I
T
Q
A
I
-
Q
-
K
Y
A
P
S
------
Y
T
D
G
-
Q
L
------
S
D
D
A
F
L
-
R
S
----
E
L
K
R
L
G
V
D
V
T
Q
----
P
AFLN
A
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
---
T
F
I
I
D
Y
P
I
E
V
S
P
L
A
R
E
S
D
T
------
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
--------
A
A
R
F
K
--------------------------
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
8
PsiBlast_PDB
77.23
51%
5
- C7 -
-
1E1T
9
SYK2_ECOLI
A:
[13-501]
----------
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
--
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
P
-
E
-
G
V
Y
N
D
-------
Q
F
K
K
W
D
----
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
D
L
-
D
N
------
F
D
A
A
K
A
-
L
A
----
E
--
S
I
G
I
T
V
E
K
----
S
----
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
7
PsiBlast_PDB
77.23
51%
3
- C7 -
-
1E1O
9
SYK2_ECOLI
A:
[13-501]
----------
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
--
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
P
-
E
-
G
V
Y
N
D
-------
Q
F
K
K
W
D
----
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
D
L
-
D
N
------
F
D
A
A
K
A
-
L
A
----
E
--
S
I
G
I
T
V
E
K
----
S
----
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
9
PsiBlast_PDB
76.82
51%
3
- C7 -
-
1E22
8
SYK2_ECOLI
A:
[13-501]
----------
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
--
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
P
-
E
-
G
V
Y
N
D
-------
Q
F
K
K
W
D
----
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
D
L
-
D
N
------
F
D
A
A
K
A
-
L
A
----
E
--
S
I
G
I
T
V
E
K
----
S
----
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
10
PsiBlast_PDB
76.64
51%
4
- C7 -
-
1E24
4
SYK2_ECOLI
A:
[13-501]
----------
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
--
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
P
-
E
-
G
V
Y
N
D
-------
Q
F
K
K
W
D
----
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
D
L
-
D
N
------
F
D
A
A
K
A
-
L
A
----
E
--
S
I
G
I
T
V
E
K
----
S
----
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
93
HHSearch
76.56
51%
2
- C7 -
-
1E1O
9
SYK2_ECOLI
A:
[11-501]
--------
A
I
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
--
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
P
-
E
-
G
V
Y
N
D
-------
Q
F
K
K
W
D
----
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
-
V
T
Y
-----
G
-------
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-
Y
R
P
E
T
D-----
M
A
D
L
-
D
N
------
F
D
A
A
K
A
-
L
A
----
E
--
S
I
G
I
T
V
E
K
----
S
----
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
4
PsiBlast_PDB
76.49
52%
3
- C7 -
-
1BBU
1
SYK1_ECOLI
A:
[11-501]
--------
V
V
D
L
N
N
E
L
K
T
R
R
E
K
-
L
A
N
L
R
E
Q
G
I
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
A
E
F
D
G
K
E
N
E
E
L
E
A
--
L
N
I
E
V
A
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
D
L
P
-
E
-
G
V
Y
N
E
-------
Q
F
K
K
W
D
----
L
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
D
I
L
-
G
K
T
E
-
V
T
Y
-----
G
-------
D
V
T
--
L
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
D
L
-
D
N
------
F
D
S
A
K
A
-
I
A
----
E
--
S
I
G
I
H
V
E
K
----
S
----
W
G
L
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
Q
R
F
L
--------------------------
D
Q
V
A
A
K
D
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
95
HHSearch
75.43
52%
1
- C7 -
-
1BBU
1
SYK1_ECOLI
A:
[11-501]
--------
V
V
D
L
N
N
E
L
K
T
R
R
E
K
-
L
A
N
L
R
E
Q
G
I
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
A
E
F
D
G
K
E
N
E
E
L
E
A
--
L
N
I
E
V
A
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
D
L
P
-
E
-
G
V
Y
-
N
E------
Q
F
K
K
W
D
----
L
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
D
I
L
-
G
K
T
E
-
V
T
Y
-----
G
-------
D
V
T
--
L
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
-
Y
R
P
E
T
D-----
M
A
D
L
-
D
N
------
F
D
S
A
K
A
-
I
A
----
E
--
S
I
G
I
H
V
E
K
----
S
----
W
G
L
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
Q
R
F
L
--------------------------
D
Q
V
A
A
K
D
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
104
HHSearch
69.79
44%
16
- C7 -
-
4UP7
1
?
A:
[11-568]
------------
K
Q
L
F
L
N
R
C
K
D
-
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
--
V
--
S
D
D
I
V
S
V
A
G
R
V
L
S
K
R
S
S
S
S
A
L
-
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
K
S
A
Y
E
-
N
K
E
D
F
-
V
S
------
L
T
K
M
I
Y
----
R
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
-
G
G
S
T
K
L
E
I
KFV
T
E
K
-------
K
M
V
--
L
D
F
T
A
P
F
K
R
I
S
Y
V
H
A
L
E
E
-
K
F
G
E
K
------
I
P
R
P
-
L
D
------
G
P
E
A
L
T
-
F
L
K
K
Q
A
I
--
R
F
N
A
I
C
A
E
----
P
----
Q
T
T
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
Q
P
---
T
F
V
C
D
Q
P
Q
L
M
S
P
L
A
K
Y
H
R
S
------
E
P
E
L
T
E
R
F
E
L
F
I
L
K
R
E
I
A
N
A
Y
T
E
L
N
N
P
I
V
Q
--------
R
S
N
F
E
--------------------------
Q
Q
A
K
D
K
A
A
G
D
D
E
A
Q
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
92
HHSearch
67.63
41%
20
- C7 -
-
4YCU
4
SYK_HUMAN
A:
[4-506]
----------
D
P
N
Q
Y
Y
K
I
R
S
Q
A
-
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
H
-
L
--
T
D
I
T
L
K
V
A
G
R
I
H
A
K
R
A
S
G
G
K
L
-
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
Y
K
S
E
-
E
E
F
-
I
H
------
I
N
N
K
L
R
----
R
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
H
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
-
G
S
Y
K
-
V
T
Y
-----
H
PDGPE
G
Q
A
Y
D
--
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
E
K
-
A
L
G
M
K
------
L
P
E
T
-
N
L
FET
E
E
T
R
K
I
L
D
D
-
I
C
----
V
--
A
K
A
V
E
C
P
P
----
P
----
R
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
---
T
F
I
C
D
H
P
Q
I
M
S
P
L
A
K
W
H
R
S
------
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
--------
R
Q
L
F
E
--------------------------
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
41
PsiBlast_CBE
65.84
41%
31
- C7 -
-
4YCU
4
SYK_HUMAN
B:
[4-506]
----------
D
P
N
Q
Y
Y
K
I
R
S
Q
A
-
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
---
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
HL
T
D
I
T
L
K
V
A
G
R
I
H
A
K
R
A
S
G
G
K
L
-
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
Y
K
-
S
-
E
---
E
-------
E
F
I
H
I
N
N
K
LR
R
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
-----
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
-
G
S
Y
K
-
V
T
Y
HPDGP
E
-------
G
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
E
K
-
A
L
G
M
K
LPETNL
F
E
T
E
-
E
T
------
R
K
I
L
D
D
-
I
C
----
V
--
A
K
A
V
E
C
P
P
----
P
----
R
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
---
T
F
I
C
D
H
P
Q
I
M
S
P
L
A
K
W
H
R
S
------
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
--------
R
Q
L
F
E
--------------------------
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
16
PsiBlast_PDB
65.53
41%
28
- C7 -
-
4YCU
4
SYK_HUMAN
A:
[4-506]
----------
D
P
N
Q
Y
Y
K
I
R
S
Q
A
-
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
---
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
HL
T
D
I
T
L
K
V
A
G
R
I
H
A
K
R
A
S
G
G
K
L
-
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
Y
K
-
S
-
E
---
E
-------
E
F
I
H
I
N
N
K
LR
R
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
H
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
-
G
S
Y
K
-
V
T
Y
H
PDGP
E
-------
G
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
E
K
-
A
L
G
M
K
L
P
E
TNL
F
E
T
E
-
E
T
------
R
K
I
L
D
D
-
I
C
----
V
--
A
K
A
V
E
C
P
P
----
P
----
R
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
---
T
F
I
C
D
H
P
Q
I
M
S
P
L
A
K
W
H
R
S
------
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
--------
R
Q
L
F
E
--------------------------
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
65
PsiBlast_CBE
52.09
34%
42
- C7 -
-
4UP7
1
?
A:
[9-568]
-----------
L
S
K
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
S
D
--
D
--
I
V
S
V
A
G
R
V
L
S
K
R
S
S
S
-
S
A
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
K
S
-------
A
Y
-
E
N
K
E
D
F
V
S
L
T
K
M
I
Y
----
R
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
G
S
T
K
-
L
E
I
-----
K
-------------------------------------------------------------F
V
T
----
E
--
K
K
M
V
L
D
F
T
----
A
P
F
K
R
I
S
Y
V
H
A
L
E
E
K
F
G
E
K
I
P
R
P
L
D
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
F
N
A
I
C
A
E
-
P
Q
T
T
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
L
A
K
YHRSEPEL
T
E
R
F
E
L
F
I
LKREI
A
N
A
Y
TELNN
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
A
G
D
D
E
A
Q
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
63
PsiBlast_CBE
51.67
34%
51
- C7 -
-
4UPA
1
?
A:
[9-568]
-----------
L
S
K
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
S
D
--
D
--
I
V
S
V
A
G
R
V
L
S
K
R
S
S
S
-
S
A
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
K
S
-------
A
Y
-
E
N
K
E
D
F
V
S
L
T
K
M
I
Y
----
R
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
G
S
T
K
-
L
E
I
-----
K
-----------------------------------------------------------------------
K
K
M
V
L
D
F
T
----
A
P
F
K
R
I
S
Y
V
H
A
L
E
E
K
F
G
E
K
I
P
R
P
L
D
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
F
N
A
I
C
A
E
-
P
Q
T
T
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
L
A
K
YHRSEPE
L
T
E
R
F
E
L
F
I
LKREI
A
N
A
Y
TELNN
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
-------
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
64
PsiBlast_CBE
50.08
34%
54
- C7 -
-
4UP9
1
?
A:
[9-568]
-----------
L
S
K
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
S
D
--
D
--
I
V
S
V
A
G
R
V
L
S
K
R
S
S
S
-
S
A
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
K
S
-------
A
Y
-
E
N
K
E
D
F
V
S
L
T
K
M
I
Y
----
R
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
G
S
T
K
-
L
E
I
-----
K
------------------------------------------------------------------------
K
M
V
L
D
F
T
----
A
P
F
K
R
I
S
Y
V
H
A
L
E
E
K
F
G
E
K
I
P
R
P
L
D
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
F
N
A
I
C
A
E
-
P
Q
T
T
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
L
A
K
YHRSEPE
L
T
E
R
F
E
L
F
I
LKREI
A
N
A
Y
TELNN
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
-------
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R