@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U5B5: (2017-12-28 )
MKKKVEVPMSKHYFDPRLKIFALNSNRPLAEKIAAAVGVELGKSSVTQFSDGEIQVNIEESIRGSHVYVIQSTSSPVNDNLMELLIMIDALKRASAKTINVVMPYYGYARQDRKARAREPITAKLVANMIQKAGATRMLTLDLHAVQIQGFFDIPVDHLMGAPLIANYFLEKGIKGDDVVVVSPDHGGVTRARKLAEFLKSPIAIIDKRRPKANVAEVMNIIGQVKGKTCVLIDDMIDTAGTITLAANALKEAGATSVYASCTHPVLSGPALQRIEDSAIERLVVTDSIYLPEDRKIDKIDEVSVGGLMGDAIKRIHENKPVSPLFETKNK
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110....-...120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290-...-..---..300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKKKVEVP
M
S
KHYFDP
R
L
K
I
F
A
LNSNR
P
L
A
E
K
I
A
A
A
V
G
V
ELGKSSVTQFSDG
E
I
Q
V
N
I
E
ESIRG
S
H
V
Y
V
I
QSTSSPV
N
D
N
L
M
E
L
L
I
M
I
D
A
L
K
RASA
K
T
I
N
V
VMPYYGYARQD
R
K
AR-AREP
I
T
A
K
L
V
A
N
M
I
Q
KAGA
T
R
M
L
T
L
D
L
H
A
V
Q
I
Q
G
F
FDI
P
V
D
H
LMG
A
P
L
I
A
N
Y
F
L
EKGIKGD
D
V
V
V
V
SPDHG
G
V
T
R
A
R
K
L
A
E
F
L
KS
P
I
A
I
IDKRRPKA
N
V
A
E
V
M
N
I
I
G
QVKG
K
T
C
V
L
I
DDMIDTA
G
T
I
T
L
A
A
N
A
L
K
EAGAT
S
V
Y
ASCTHPVLS
G
P
A
L
Q
R
I
E
D
S
A
I
E
R
L
V
VTD
S
I
YLP-EDR-KI---DKIDEVSVG
G
L
M
G
D
A
I
K
R
I
HENKPVSPLFETKNK
62
HHSearch
90.66
70%
-167
- C8 -
-
1DKR
-
KPRS_BACSU
B:
[3-316]
----------
N
Q
Y
G
D
K
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
-
E
G
-
K
N
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
P
-
E
E
K
-
K
I
---
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-----
63
HHSearch
89.51
70%
-169
- C8 -
-
1DKU
3
KPRS_BACSU
A:
[9-316]
----------------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
-
E
G
-
K
N
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
------
K
I
---
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-----
82
Fugue
88.99
70%
-167
- C8 -
-
1DKU
3
KPRS_BACSU
A:
[9-316]
----------------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
N
L
--
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
-----
K
L
-
K
I
---
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-----
1
PsiBlast_PDB
88.84
69%
-169
- C8 -
-
1DKU
3
KPRS_BACSU
A:
[9-316]
----------------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
N
L
--
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
------
K
I
---
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-----
21
PsiBlast_CBE
88.43
69%
-170
- C8 -
-
1DKU
3
KPRS_BACSU
B:
[9-316]
----------------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
N
L
--
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
------
K
I
---
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-----
6
PsiBlast_PDB
81.85
46%
-151
- C8 -
-
4LYG
-
PRPS1_HUMAN
A:
[3-313]
----------------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
T
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
-
Q
E
D
-
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-----
10
PsiBlast_PDB
81.80
46%
-148
- C8 -
-
3EFH
-
PRPS1_HUMAN
A:
[3-313]
----------------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
K
-------
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
-
Q
E
D
-
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-----
4
PsiBlast_PDB
81.65
47%
-145
- C8 -
-
4F8E
-
PRPS1_HUMAN
A:
[2-313]
---------------
P
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
H
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
-------
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
-
Q
E
D
-
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-----
8
PsiBlast_PDB
80.85
46%
-144
- C8 -
-
2H06
-
PRPS1_HUMAN
A:
[3-313]
----------------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
-
Q
E
D
-
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-----
15
PsiBlast_PDB
80.29
46%
-147
- C8 -
-
4M0U
-
PRPS1_HUMAN
A:
[3-312]
----------------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
P
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
-
Q
E
D
-
K
M
KHC
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
------
5
PsiBlast_PDB
80.19
47%
-144
- C8 -
-
2H08
-
PRPS1_HUMAN
A:
[3-313]
----------------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
M
A
E
P
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
-
Q
E
D
-
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-----
13
PsiBlast_PDB
80.10
46%
-145
- C8 -
-
4LZN
-
PRPS1_HUMAN
B:
[3-313]
----------------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
N
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
-
Q
E
D
-
K
M
KHC
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-----
9
PsiBlast_PDB
79.97
46%
-145
- C8 -
-
2HCR
2
PRPS1_HUMAN
A:
[3-313]
----------------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
-
Q
E
D
-
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-----
14
PsiBlast_PDB
79.96
46%
-143
- C8 -
-
4M0P
-
PRPS1_HUMAN
A:
[3-313]
----------------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
T
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
-
Q
E
D
-
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-----
11
PsiBlast_PDB
79.91
46%
-147
- C8 -
-
3S5J
-
PRPS1_HUMAN
B:
[3-313]
----------------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
-
Q
E
D
-
K
M
KHC
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-----
38
PsiBlast_CBE
79.67
46%
-145
- C8 -
-
5T3O
1
?
B:
[2-306]
-----------------
L
L
I
F
S
G
Q
S
N
R
P
L
A
Q
A
I
A
E
A
L
G
L
P
L
G
K
S
T
T
L
R
F
A
N
D
N
L
F
V
R
Y
E
E
S
L
R
E
G
D
V
F
I
V
Q
S
F
V
P
P
V
Q
D
H
L
M
E
L
L
M
M
V
D
A
A
K
G
A
S
A
A
R
V
T
A
V
I
P
Y
F
S
Y
A
R
S
D
K
K
D
A
-
P
R
I
S
I
T
A
R
L
I
A
D
L
L
Q
T
A
G
A
D
R
V
L
T
M
T
L
H
S
P
Q
V
H
G
F
F
K
I
P
V
D
H
L
S
A
E
P
V
I
A
N
Y
F
A
T
R
-
V
D
L
E
N
A
V
V
V
A
P
D
A
G
D
L
K
R
A
S
A
L
A
R
R
L
G
L
P
L
A
F
I
D
K
E
R
V
S
D
T
E
V
R
V
R
M
L
V
G
E
V
E
G
K
T
A
L
I
V
D
D
E
I
S
T
A
G
S
L
V
E
A
V
E
A
L
M
Q
A
G
A
K
E
V
Y
A
A
A
T
H
G
V
Y
V
G
P
A
L
D
R
I
A
K
S
P
V
K
E
V
A
A
T
D
T
C
P
P
K
-
E
G
P
-
K
L
---
R
T
L
---
T
V
A
P
L
F
A
E
A
I
W
R
I
H
R
G
E
S
V
S
S
L
F
-----
7
PsiBlast_PDB
79.65
46%
-146
- C8 -
-
2H07
-
PRPS1_HUMAN
A:
[3-313]
----------------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
A
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
-
Q
E
D
-
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-----
31
PsiBlast_CBE
79.48
46%
-144
- C8 -
-
2HCR
2
PRPS1_HUMAN
B:
[3-313]
----------------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
--
P
-
Q
E
D
-
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-----
37
PsiBlast_CBE
79.41
46%
-155
- C8 -
-
5T3O
1
?
C:
[2-306]
-----------------
L
L
I
F
S
G
Q
S
N
R
P
L
A
Q
A
I
A
E
A
L
G
L
P
L
G
K
S
T
T
L
R
F
A
N
D
N
L
F
V
R
Y
E
E
S
L
R
E
G
D
V
F
I
V
Q
S
F
V
P
P
V
Q
D
H
L
M
E
L
L
M
M
V
D
A
A
K
G
A
S
A
A
R
V
T
A
V
I
P
Y
F
S
Y
A
R
S
D
K
K
D
A
-
P
R
I
S
I
T
A
R
L
I
A
D
L
L
Q
T
A
G
A
D
R
V
L
T
M
T
L
H
S
P
Q
V
H
G
F
F
K
I
P
V
D
H
L
S
A
E
P
V
I
A
N
Y
F
A
T
R
-
V
D
L
E
N
A
V
V
V
A
P
D
A
G
D
L
K
R
A
S
A
L
A
R
R
L
G
L
P
L
A
F
I
D
K
E
R
V
S
D
T
E
V
R
V
R
M
L
V
G
E
V
E
G
K
T
A
L
I
V
D
D
E
I
S
T
A
G
S
L
V
E
A
V
E
A
L
M
Q
A
G
A
K
E
V
Y
A
A
A
T
H
G
V
Y
V
G
P
A
L
D
R
I
A
K
S
P
V
K
E
V
A
A
T
D
T
C
P
P
K
-
E
G
P
-
K
L
---
R
T
L
---
T
V
A
P
L
F
A
E
A
I
W
R
I
H
R
G
E
S
V
S
S
L
F
-----
64
HHSearch
79.40
47%
-151
- C8 -
-
5T3O
1
?
C:
[1-307]
----------------
P
L
L
I
F
S
G
Q
S
N
R
P
L
A
Q
A
I
A
E
A
L
G
L
P
L
G
K
S
T
T
L
R
F
A
N
D
N
L
F
V
R
Y
E
E
S
L
R
E
G
D
V
F
I
V
Q
S
F
V
P
P
V
Q
D
H
L
M
E
L
L
M
M
V
D
A
A
K
G
A
S
A
A
R
V
T
A
V
I
P
Y
F
S
Y
A
R
S
D
K
K
D
A
-
P
R
I
S
I
T
A
R
L
I
A
D
L
L
Q
T
A
G
A
D
R
V
L
T
M
T
L
H
S
P
Q
V
H
G
F
F
K
I
P
V
D
H
L
S
A
E
P
V
I
A
N
Y
F
-
A
T
R
V
D
L
E
N
A
V
V
V
A
P
D
A
G
D
L
K
R
A
S
A
L
A
R
R
L
G
L
P
L
A
F
I
D
K
E
R
V
S
D
T
E
V
R
V
R
M
L
V
G
E
V
E
G
K
T
A
L
I
V
D
D
E
I
S
T
A
G
S
L
V
E
A
V
E
A
L
M
Q
A
G
A
K
E
V
Y
A
A
A
T
H
G
V
Y
V
G
P
A
L
D
R
I
A
K
S
P
V
K
E
V
A
A
T
D
T
C
P
P
K
-
E
G
-------
P
K
L
R
T
L
T
V
A
P
L
F
A
E
A
I
W
R
I
H
R
G
E
S
V
S
S
L
F
T
----
23
PsiBlast_CBE
75.61
55%
-52
- C8 -
-
3DAH
2
?
C:
[7-313]
----------------
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
N
Y
P
--
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
I
I
D
K
R
R
-------
V
M
N
I
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
S
L
-
A
C
---
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
--------
70
HHSearch
75.11
55%
-50
- C8 -
-
3DAH
2
?
C:
[7-313]
----------------
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
-
R
K
Q
-
N
Y
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
I
I
D
K
R
R
-------
V
M
N
I
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
-
A
E
S
L
A
C
---
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
--------
24
PsiBlast_CBE
74.00
55%
-55
- C8 -
-
3DAH
2
?
B:
[6-316]
---------------
D
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
N
Y
P
--
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
-----------------
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
S
L
-
A
C
---
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
F
-----
71
HHSearch
73.49
55%
-53
- C8 -
-
3DAH
2
?
B:
[6-316]
---------------
D
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
-
R
K
Q
-
N
Y
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
-----------------
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
-
A
E
S
L
A
C
---
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
F
-----
2
PsiBlast_PDB
73.30
55%
-61
- C8 -
-
3DAH
1
?
A:
[6-315]
---------------
D
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
N
Y
P
--
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
I
--------------------
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
S
L
-
A
C
---
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
------