@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U5K2: (2017-12-29 )
MKSLAGHVVKYGKHRERRSFARISEVLELPNLIEIQTDSYQWFLDEGLREMFEDILPIDDFNGNLSLEFVDYELKEPKYTVAEARAHDANYSAPLHVTLRLTNRETGEIKAQEVFFGDFPLMTEQGTFIINGAERVIVSQLVRSPGVYFHGKVDKNGKEGFGSTVIPNRGAWLEMETDAKDISYVRIDRTRKIPLTVLVRALGFGSDDTIFEIFGDSETLRNTVEKDLHKNASDSRTEEGLKDVYERLRPGEPKTADSSRNLLNARFFDPKRYDLANVGRYKVNKKLDLKTRLLNLTLAETLVDPETGEIIVEKGTVLTHQVMETLAPFIDNGLNSVTYYPSEDGVVTDPMTVQVIKVFSPRDPEREVNVIGNGYPEAAVKTVRPADIIASMSYFLNLMEGIGNVDDIDHLGNRRIRSVGELLQNQFRIGLARMERVVRERMSIQDTETLTPQQLINIRPVVASIKEFFGSSQLSQFMDQTNPLGELTHKRRLSALGPGGLTRDRAGYEVRDVHYSHYGRMCPIETPEGPNIGLINSLSSYAKVNKFGFIETPYRRVDRETGRVTDQIDYLTADIEDHYIVAQANSPLNEDGTFAQDVVMARAQSENLEVSIDKVDYMDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLINPQAPWVGTGMEYKSAHDSGAALLCKHDGVVEYVDASEIRVRRDNGALDKYDVTKFRRSNSGTSYNQRPIVHLGEKVEKGDTLADGPSMEQGEMALGQNVLVGFMTWEGYNYEDAIIMSRRLVKDDVYTSIHIEEYESEARDTKLGPEEITREIPNVGEDALKDLDEMGIIRIGAEVQDGDLLVGKVTPKGVTELSAEERLLHAIFGEKAREVRDTSLRVPHGGGGIVHDVKIFTREAGDELSPGVNMLVRVYIVQKRKIHEGDKMAGRHGNKGVVSRIMPEEDMPFLPDGTPIDIMLNPLGVPSRMNIGQVLELHLGMAARQLGIHVATPVFDGASDEDVWETVREAGMASDAKTVLYDGRTGEPFDGRVSVGVMYMIKLAHMVDDKLHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTYKSDDVVGRVKTYEAIVKGEPIPKPGVPESFRVLVKELQSLGLDMRVLDIEETEIELRDMDDEDDDLITVDALTKFAEQQTAKELEKKAAEQVEDEKDDVIQNFETAEDNLD
Atome Classification :
(66 SA)
.........10........20........30........40....-----------------.-----------------...50........60---........70........80........90........100....-------...110.......120.......130.......140.......150....---.-..160....--...170.......180.......190.......200.......210.......220---------.-.-------------------------------.....-------------------.--------------------------------------------------.230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400------------..------------.------------....410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600..-.....-610.......620.......630.......640.......650.......660.......670.......680.......690.......700-------.-------......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880...-....890-......----------------------------------------------------------------------------------------------------.900.......910.......920.......930.......940.......950.......960.......970.......980-----------------------....------------------.-------------------------....990-----------------------------------------------------......-----------------------------..1000--------.--------.--------.-----------------------------.---..--------------1010.--------------.....1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
S
L
A
G
H
V
V
K
Y
G
K
H
R
E
R
R
S
F
A
R
I
S
E
V
L
ELP
N
L
I
E
I
QTD
S
Y
Q
W
F
L
D
-----------------
E
-----------------
G
L
R
E
M
F
E
D
ILPIDDF---NG
N
L
S
L
E
F
V
D
Y
ELKEP
K
Y
T
V
A
EARAHDANYSA
P
L
H
V
T
L
R
LTNRET-------G
E
I
K
A
Q
E
V
F
FGDFPLMTEQ
G
T
F
I
ING
A
E
R
V
I
V
S
Q
L
V
RSP
G
V
Y
F
H
G
KVDKN---G-KEGFGSTVI--PNRG
A
W
L
E
M
ETDAKD
I
S
Y
V
R
IDRTRKI
P
L
T
V
L
V
R
A
LGFGSDD
T
I
F
E
I
FG
D
S
E
T
L
-----------
R
-
N
-------------------------------
T
V
E
K
D
-------------------
L
--------------------------------------------------HKNASDS
R
T
E
E
G
L
K
D
V
Y
E
RLRPGEPKTADSSRNLLNARFFDPKRYDLANVGRYKVNKKLDL
K
T
R
L
L
N
L
T
L
A
E
T
LVDPETG
E
I
I
V
EKG
T
V
L
T
H
Q
V
M
E
T
L
A
P
F
I
DNGLNS
V
T
YYPSEDGVVTDP
M
T
V
Q
V
I
K
VFSPRDPER
E
V
N
V
IGNGY
P
E
A
A
VKTV
R
P
A
D
I
I
A
S
M
S
Y
F
L
N
L
M
E
GI------------GN------------V------------
D
D
I
D
H
LG
N
R
R
I
R
S
V
G
E
L
L
Q
N
Q
F
R
I
G
L
A
R
M
E
R
V
V
R
E
R
MSIQDTETL
T
P
Q
Q
L
I
NI
R
P
V
V
A
S
I
K
E
F
F
G
S
S
Q
L
S
Q
F
M
DQTN
P
L
G
E
L
T
H
K
R
R
L
SALGPGGLTRDRAG
Y
E
V
R
D
V
H
Y
S
HYGRMCPIETPEGPNI
G
L
I
N
S
L
S
S
Y
A
K
VNKFGFIE
T
P
Y
R
R
VDRETGRVTDQI
D
Y
L
TADIED
H
Y
I
V
A
QANSPLNEDG
T
F
A
Q
D
V
V
M
A
RAQ-SEN
L
E
-
V
S
I
D
K
V
D
Y
MDV
S
P
K
Q
V
V
A
V
A
T
A
C
I
P
FLENDDSN
R
A
L
MGANMQRQAVPLINPQAPWVGTGMEYKSAHDS
G
A
A
L
L
C
KHDG
V
V
E
Y
VDA
S
E
I
R
V
RRD-------N-------GALDK
Y
D
V
T
K
F
RRSNSGTSYNQRP
I
V
HLGEKVEKGDTLADGPSM
E
Q
G
E
M
ALGQ
N
V
L
V
G
F
M
TWEGYNY
E
D
A
I
I
M
S
R
R
L
VKDDV
Y
T
S
I
H
I
E
E
Y
E
S
EARDTKL
G
P
E
E
I
T
R
EIPNV
G
E
D
A
L
K
D
L
D
EM
G
I
I
R
IGAEVQDG
D
L
L
V
GKVTPK
G
V
T
EL
S
A
E
E
R
L
L
H
A
I
F
G
E
K
A
R
E
VRDTSLRVPHGGG
G
I
-
V
H
D
V
K
I
F
-
T
REAGD----------------------------------------------------------------------------------------------------ELS
P
G
V
N
M
L
V
R
V
Y
I
V
Q
K
RKIHEGDKMAGRHGNK
G
V
V
S
RIMPEEDMPFLPDG
T
P
I
D
I
M
LNPLGVPSRM
N
I
G
Q
V
L
E
L
H
L
G
M
A
A
R
-------------------------QLG
I
------------------
H
-------------------------
V
ATPVF------------------------------------------------------DGAS
D
E
-----------------------------
D
V
W
E
T
V
--------
R
--------E--------A-----------------------------G---MA--------------SDA
K
T
--------------
V
L
YDGRTGEPFDGR
V
S
V
G
V
M
Y
M
I
K
L
A
H
M
VDDKLHARSIGPY
S
L
V
TQQPLGGKAQFGGQRFGE
M
E
V
W
A
L
EAYG
A
A
Y
T
L
Q
E
I
L
T
YKSDDVVG
R
V
K
T
Y
E
A
I
VKGEPIPKPGV
P
E
S
F
R
V
L
V
K
E
L
Q
SLGL
D
M
R
V
L
DIEE
T
E
I
E
L
RDMDDEDD
D
L
I
T
V
D
A
L
T
K
F
A
E
Q
Q
T
A
K
E
L
E
K
K
A
A
E
Q
VED
E
K
D
D
V
I
Q
N
FETAEDNLD
121
HHSearch
91.59
55%
0
- C- -
-
2PPB
6
RPOB_THET8
M:
[2-1109]
---------------
E
I
K
R
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
Q
-----------------
A
DVPPEKRENV-------
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
E
DKG
K
G
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
H
K
D
T
-------
G
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
T
P
D
P
A
R
----
P
--
G
R
Y
I
A
S
I
I
PL
P
K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
K
-
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
-
T
L
A
R
E
L
G
A
Y
G
E
L
-----------
V
-
Q
-------------------------------
G
L
M
D
E
-------------------
S
-----------------------------------------------------
V
F
A
M
R
P
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
I
R
L
S
G
-------
R
T
---------
L
--------------------------------------------------------
A
R
F
E
-------
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
PG----------
H
E
------------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
--
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
-
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
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T
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D
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H
L
S
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A
A
L
R
D
L
D
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V
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G
A
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V
K
P
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D
I
L
V
G
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F
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G
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S
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P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
-
V
V
R
T
V
R
L
R
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
EIKELLAQAFEVYFGKRKGEGFGVDKREV
E
V
L
R
R
A
--------
E
--------
K
--------
L
-----------------------------
G
---
L
V
TPGKTPEEQLKELF
L
Q
G
K
V
--------------
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
---------------------------------------------------------
76
PsiBlast_CBE
70.08
58%
0
- C- -
-
2A68
1
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
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P
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R
F
Y
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Q
G
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A
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L
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A
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E
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A
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D
L
D
E
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V
R
I
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A
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V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
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W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
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P
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P
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V
P
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R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
75
PsiBlast_CBE
70.08
58%
0
- C- -
-
2A68
1
RPOB_THET8
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
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L
A
R
G
V
R
E
R
M
L
M
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S
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D
S
L
T
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A
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L
V
N
S
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P
L
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A
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E
F
F
S
R
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Q
L
S
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F
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D
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T
N
P
L
S
S
L
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H
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R
R
I
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A
L
G
P
G
G
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A
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V
R
D
V
H
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Y
G
R
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C
P
V
E
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E
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A
N
I
G
L
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S
L
A
A
Y
A
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V
D
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F
I
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T
P
Y
R
R
V
--
V
G
G
V
V
T
D
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V
V
Y
M
T
A
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D
R
Y
T
I
A
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A
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T
P
L
-
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G
N
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V
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A
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K
-
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L
I
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A
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R
A
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Q
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P
L
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A
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A
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V
V
M
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L
E
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V
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L
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R
I
V
V
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E
-------
D
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V
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I
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A
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V
K
P
G
D
I
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V
G
R
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F
K
G
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T
P
E
E
R
L
L
R
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I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
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K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
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P
L
G
G
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A
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F
G
G
Q
R
F
G
E
M
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W
A
L
E
A
Y
G
A
A
H
T
L
Q
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M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
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V
L
V
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E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
74
PsiBlast_CBE
70.08
58%
0
- C- -
-
2A69
1
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
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G
L
A
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L
A
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M
L
M
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D
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P
L
S
S
L
R
H
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R
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A
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G
P
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V
R
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P
V
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A
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G
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L
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A
Y
A
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F
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Y
R
R
V
--
V
G
G
V
V
T
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V
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V
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L
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R
I
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-------
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E
A
A
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R
D
L
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R
I
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A
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V
K
P
G
D
I
L
V
G
R
T
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F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
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I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
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D
M
P
H
L
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D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
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K
M
H
A
R
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T
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P
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S
L
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P
L
G
G
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A
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F
G
G
Q
R
F
G
E
M
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W
A
L
E
A
Y
G
A
A
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T
L
Q
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M
L
T
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I
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R
N
A
A
Y
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A
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I
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V
L
V
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E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
73
PsiBlast_CBE
70.08
58%
0
- C- -
-
2A69
1
RPOB_THET8
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
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G
N
R
R
I
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E
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--
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----------------------------------------------------------------------------------------------------
E
L
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V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
64
PsiBlast_CBE
70.08
58%
0
- C- -
-
2PPB
4
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
63
PsiBlast_CBE
70.08
58%
0
- C- -
-
2PPB
6
RPOB_THET8
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
118
HHSearch
67.69
62%
42
- C2 -
-
5UHA
2
RPOB_MYCTU
C:
[35-1153]
-------------
A
P
N
R
V
S
F
A
K
L
R
E
P
L
E
V
P
G
L
L
D
V
Q
T
D
S
F
E
W
L
I
G
-----------------
S
P
R
W
R
E
S
A
A
E
R
GDVNPVG
G
L
E
E
V
L
Y
E
L
S
P
I
E
D
F
---
S
G
S
M
S
L
S
F
S
D
P
R
F
D
D
V
K
A
P
V
D
E
C
K
D
K
D
M
T
Y
A
A
P
L
F
V
T
A
E
F
I
N
N
N
T
-------
G
E
I
K
S
Q
T
V
F
M
G
D
F
P
M
M
T
E
K
G
T
F
I
I
N
G
T
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R
V
V
V
S
Q
L
V
R
S
P
G
V
Y
F
D
E
T
I
D
K
S
---
T
D
K
T
L
H
S
V
K
V
I
--
P
S
R
G
A
W
L
E
F
D
V
D
K
R
D
T
V
G
V
R
I
D
R
K
R
R
Q
P
V
T
V
L
L
K
A
L
G
W
T
S
E
-
Q
I
V
E
R
F
G
F
S
E
I
M
-----------
R
-
S
-------------------------------
T
L
E
--------------------------------------------------------------------------
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
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K
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A
Q
T
L
L
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N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
L
H
V
G
E
--------------------------------------------------------------------------------
P
---
I
T
S
S
T
L
T
E
E
D
V
V
A
T
I
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Y
L
V
R
L
H
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Q
T
T
M
T
V
PGG
V
E
V
P
V
E
------------
T
------------
D
D
I
D
H
F
G
N
R
R
L
R
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G
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L
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V
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A
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R
L
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A
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G
G
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V
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Y
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P
N
I
G
L
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L
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Y
A
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V
N
P
F
G
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Y
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K
V
V
D
--
G
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A
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M
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A
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G
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A
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Y
I
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M
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-------
N
-------
G
T
R
R
T
Y
R
M
R
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A
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A
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I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
E
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
A
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
C
A
H
-------------------------
S
G
W
K
------------------
V
DAAKGVPDWAARLPDELLEAQPN
A
I
V
S
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
A
-----------------------------
E
L
Q
G
L
L
--------
S
--------
C
T
L
P
N
RDGD
V
-----------------------------
L
---
V
D
--------------
A
D
G
K
A
--------------
M
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
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P
G
I
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
L
R
E
G
E
D
E
-------------------------------------------------
117
HHSearch
66.78
64%
45
- C2 -
-
5VI8
2
RPOB_MYCS2
C:
[25-1139]
------------
G
A
P
N
R
V
S
F
A
K
L
R
E
P
L
E
V
P
G
L
L
D
V
Q
T
D
S
F
E
W
L
V
G
SDRWRQAAIDRGEENPV
G
-----------------
G
L
E
E
V
L
A
E
L
S
P
I
E
D
F
---
S
G
S
M
S
L
S
F
S
D
P
R
F
D
E
V
K
A
S
V
D
E
C
K
D
K
D
M
T
Y
A
A
P
L
F
V
T
A
E
F
I
N
N
N
T
-------
G
E
I
K
S
Q
T
V
F
M
G
D
F
P
M
M
T
E
K
G
T
F
I
I
N
G
T
E
R
V
V
V
S
Q
L
V
R
S
P
G
V
Y
F
D
E
T
I
D
K
S
---
T
E
K
T
L
H
S
V
K
V
I
--
P
G
R
G
A
W
L
E
F
---------
V
R
I
D
R
K
R
R
Q
P
V
T
V
L
L
K
A
L
G
W
T
-
N
E
Q
I
V
E
R
F
G
F
S
E
I
M
-----------
M
-
G
-------------------------------
T
L
E
--------------------------------------------------------------------------
K
D
T
T
S
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
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N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
----------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
TSMTVPGGVEVP
V
E
------------
V
------------
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
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V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
E
N
--
G
V
V
T
D
Q
I
D
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
T
D
E
N
G
R
F
T
E
D
R
V
M
V
R
K
K
G
G
E
V
E
F
-
V
S
A
D
Q
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
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R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
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L
R
A
A
I
D
A
G
D
V
V
V
A
D
K
T
G
V
I
E
E
V
S
A
D
Y
I
T
V
M
A
D
-------
D
-------
G
T
R
Q
S
Y
R
L
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
R
P
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V
D
A
G
Q
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
Q
N
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
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D
A
I
I
L
S
N
R
L
V
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V
L
T
S
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H
I
E
E
H
E
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D
A
R
D
T
K
L
G
A
E
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T
R
D
I
P
N
V
S
D
E
V
L
A
D
L
D
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R
G
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V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
D
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
P
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
V
A
K
-------------------------
A
G
W
N
IDVAAGVP----------
D
WASKLPEELYSAPADST--------
V
A
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
G
ELAG-------------------------
L
L
G
S
T
L
--------
P
--------
N
--------
R
D----------------------------
G
EVM
V
D
--------------
A
D
G
K
S
--------------
T
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
L
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
E
P
G
I
P
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S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
M
R
------------------------------------------------------
119
HHSearch
66.74
57%
47
- C2 -
-
5UAC
1
RPOB_ECOLI
C:
[1-1341]
-----
M
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
-----------------
Q
DPEGQY-----------
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
---
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
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Q
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V
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Y
S
A
P
L
R
V
K
L
R
L
V
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EAPEGTV
K
D
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K
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Q
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V
Y
M
G
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P
L
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T
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N
G
T
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V
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F
D
S
D
K
G
K
T
HSS
G
-
K
V
L
Y
N
A
R
I
I
--
P
Y
R
G
S
W
L
D
F
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F
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R
R
R
K
L
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T
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L
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L
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K
L
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P
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RLRGETAS
F
D
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NGKVYVEKGRRIT
A
R
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L
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D
DVK
L
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VEYIAG
K
V
V
A
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D
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ESTGELICAAN
M
E
L
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L
D
L
L
A
K
L
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GHK
R
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L
FTNDLDHGP
Y
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L
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P
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D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
-------------------------------------------------------------------------------------
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
------------
G
E
------------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
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R
V
G
L
V
R
V
E
R
A
V
K
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R
L
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L
G
D
L
D
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L
M
P
Q
D
M
I
N
A
K
P
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S
A
A
V
K
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F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
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A
L
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P
G
G
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T
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V
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Y
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F
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A
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G
A
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M
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R
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A
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P
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L
R
A
D
K
P
L
V
G
T
G
M
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R
A
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A
V
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A
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A
K
R
G
G
V
V
Q
Y
V
D
A
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R
I
V
I
K
V
N
-------
E
DEMYPGE
A
G
I
D
I
Y
N
L
T
K
Y
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R
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N
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C
I
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M
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L
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K
R
A
L
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L
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L
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L
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L
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AGGVE
A
E
K
L
D
K
L
PRDRWLE
L
G
L
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E
K
Q
N
Q
L
E
Q
L
A
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Y
D
E
L
K
H
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E
K
K
L
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K
R
R
K
I
T
QGD
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
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K
M
A
G
R
H
G
N
K
G
V
I
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K
I
N
P
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M
P
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D
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N
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V
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S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
-------------------------
G
I
G
D
------------------
K
-------------------------
I
N
A
M
L
K
Q
QQE
V
A
K
L
R
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F
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R
A
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D
LGADVRQKVDLSTFSD
E
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M
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L
A
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L
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A
T
P
VF
D
G
A
K
E
A
-----------------------------
E
I
K
E
L
L
--------
K
--------
L
--------
G
-----------------------------
D
---
L
P
--------------
T
S
G
Q
I
--------------
R
L
Y
D
G
R
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G
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Q
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E
D
---------------------------------------------------------------
1
PsiBlast_PDB
62.70
64%
42
- C2 -
-
5TW1
2
RPOB_MYCS2
C:
[323-1139]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
------------
T
S
MTVPGGVEVPVE
V
------------
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
L
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
--
E
N
G
V
V
T
D
Q
I
D
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
T
D
E
N
G
R
F
T
E
D
R
V
M
V
R
K
K
-
G
G
E
V
E
F
V
S
A
D
Q
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
D
K
T
G
V
I
E
E
V
S
A
D
Y
I
T
V
M
A
D
-------
D
-------
G
T
R
Q
S
Y
R
L
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
R
P
I
V
D
A
G
Q
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
Q
N
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
V
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
D
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
P
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
V
A
K
AGWNIDV------------------
A
A
G
V
PDWASKLPEELYSAPADS
T
-------------------------
V
A
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
G
-----------------------------
E
L
A
G
L
L
GSTLPNRD
G
--------
E
--------
V
-----------------------------
M
---
V
D
--------------
A
D
G
K
S
--------------
T
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
L
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
E
P
G
I
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
M
R
------------------------------------------------------
36
PsiBlast_CBE
62.58
58%
23
- C2 -
-
5D4C
4
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
53
PsiBlast_CBE
62.52
58%
22
- C2 -
-
4G7H
2
RPOB_THET8
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
2
PsiBlast_PDB
62.50
64%
42
- C2 -
-
5VI8
2
RPOB_MYCS2
C:
[323-1139]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
------------
T
S
MTVPGGVEVPVE
V
------------
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
L
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
--
E
N
G
V
V
T
D
Q
I
D
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
T
D
E
N
G
R
F
T
E
D
R
V
M
V
R
K
K
-
G
G
E
V
E
F
V
S
A
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Q
V
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Y
M
D
V
S
P
R
Q
M
V
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V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
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A
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M
Q
R
Q
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V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
D
K
T
G
V
I
E
E
V
S
A
D
Y
I
T
V
M
A
D
-------
D
-------
G
T
R
Q
S
Y
R
L
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
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A
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N
L
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P
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I
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I
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L
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I
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N
V
S
D
E
V
L
A
D
L
D
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G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
D
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
P
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
V
A
K
AGWNIDV------------------
A
A
G
V
PDWASKLPEELYSAPADS
T
-------------------------
V
A
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
G
-----------------------------
E
L
A
G
L
L
GSTLPNRD
G
--------
E
--------
V
-----------------------------
M
---
V
D
--------------
A
D
G
K
S
--------------
T
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
L
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
E
P
G
I
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
M
R
------------------------------------------------------
46
PsiBlast_CBE
62.36
58%
23
- C2 -
-
4MQ9
1
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
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R
V
V
A
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R
K
-
G
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V
I
-
V
S
P
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V
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F
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V
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V
N
T
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A
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P
L
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A
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V
M
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L
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V
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A
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G
E
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V
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N
R
I
V
V
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E
-------
D
-------
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R
L
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L
L
R
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I
F
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K
A
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D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
GKRKGEGFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
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V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
32
PsiBlast_CBE
62.32
58%
24
- C2 -
-
5E17
2
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
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G
L
A
R
L
A
R
G
V
R
E
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M
L
M
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S
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D
S
L
T
P
A
K
L
V
N
S
R
P
L
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A
A
I
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F
F
S
R
S
Q
L
S
Q
F
K
D
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N
P
L
S
S
L
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R
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A
L
G
P
G
G
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R
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D
V
R
D
V
H
R
T
H
Y
G
R
I
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P
V
E
T
P
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A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
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F
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T
P
Y
R
R
V
--
V
G
G
V
V
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V
Y
M
T
A
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Y
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A
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T
P
L
-
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N
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A
A
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V
V
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V
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G
N
R
I
V
V
R
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E
-------
D
-------
G
R
L
V
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P
L
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R
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V
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A
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V
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A
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L
L
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I
F
G
E
K
A
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V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
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T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
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M
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M
H
A
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P
Y
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L
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P
L
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K
A
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F
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G
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F
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E
M
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A
L
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A
Y
G
A
A
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T
L
Q
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M
L
T
L
K
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D
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R
N
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A
Y
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A
I
I
K
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E
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V
L
V
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E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
51
PsiBlast_CBE
62.29
58%
22
- C2 -
-
4G7O
3
RPOB_THET8
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
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A
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L
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V
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M
L
M
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A
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L
V
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S
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P
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A
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F
F
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R
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Q
L
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F
K
D
E
T
N
P
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S
L
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R
R
I
S
A
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P
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V
--
V
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R
Y
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A
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V
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K
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D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
54
PsiBlast_CBE
62.27
58%
22
- C2 -
-
4G7H
2
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
33
PsiBlast_CBE
62.27
58%
24
- C2 -
-
5D4E
1
RPOB_THET8
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
11
PsiBlast_PDB
62.20
62%
43
- C2 -
-
5UHE
3
RPOB_MYCTU
C:
[332-1153]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
------------
T
T
------------
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
--
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
-
A
G
E
V
E
Y
V
P
S
S
E
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D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
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A
A
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D
A
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D
V
V
V
A
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S
G
V
I
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A
D
Y
I
T
V
M
H
D
-------
N
-------
G
T
R
R
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Y
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F
A
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T
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A
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A
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D
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E
A
G
Q
V
I
A
D
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P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
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D
V
L
T
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I
H
I
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E
H
E
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D
A
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D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
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V
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D
I
L
V
G
K
V
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T
E
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T
P
E
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R
L
L
R
A
I
F
G
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A
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L
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P
H
G
E
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G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
E
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
A
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
C
A
H
S
G
W
K
V
DAAKGVPDWAARLPDELLEA
Q
P
N
A
------------------
I
-------------------------
V
S
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
A
-----------------------------
E
L
Q
G
L
L
--------
S
C
T
L
P
N
RDG
D
--------
V
-----------------------------
L
---
V
D
--------------
A
D
G
K
A
--------------
M
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
E
P
G
I
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
L
R
E
G
E
D
E
-------------------------------------------------
43
PsiBlast_CBE
62.19
58%
26
- C2 -
-
4OIP
4
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
52
PsiBlast_CBE
62.15
58%
22
- C2 -
-
4G7O
3
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
GKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
24
PsiBlast_CBE
62.13
58%
26
- C2 -
-
5X22
2
?
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
40
PsiBlast_CBE
62.08
58%
23
- C2 -
-
4Q4Z
3
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
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R
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L
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M
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L
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F
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I
S
A
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P
G
G
L
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E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
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E
D
R
Y
T
I
A
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A
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T
P
L
-
E
G
N
R
I
A
A
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R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
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V
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F
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P
K
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F
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V
N
T
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F
L
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D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
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E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
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R
Y
E
I
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A
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D
T
K
L
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P
E
R
I
T
R
D
I
P
H
L
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A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
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R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
29
PsiBlast_CBE
62.08
58%
25
- C2 -
-
5I2D
1
RPOB_THET8
N:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
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P
L
R
R
F
Y
R
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N
Q
G
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A
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D
Q
R
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V
V
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Q
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D
L
L
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G
F
L
A
L
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Q
N
V
L
V
A
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M
P
F
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Y
N
F
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D
A
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E
L
L
K
R
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F
Y
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I
H
I
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Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
30
PsiBlast_CBE
62.05
58%
24
- C2 -
-
5I2D
1
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
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A
A
I
R
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F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
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V
N
T
N
L
I
P
F
L
E
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D
D
A
N
R
A
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G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
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E
D
G
E
V
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K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
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Y
P
L
R
R
F
Y
R
S
N
Q
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A
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D
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V
V
G
Q
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V
R
K
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L
A
D
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P
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N
G
F
L
A
L
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Q
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V
L
V
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M
P
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Y
N
F
E
D
A
I
V
I
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E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
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I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
41
PsiBlast_CBE
62.01
58%
24
- C2 -
-
4OIR
3
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
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R
Y
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I
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A
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D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
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A
A
L
R
D
L
D
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G
V
V
R
I
G
A
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V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
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P
S
V
P
E
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F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
8
PsiBlast_PDB
61.99
62%
45
- C2 -
-
5UHB
3
RPOB_MYCTU
C:
[332-1153]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
------------
T
T
------------
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
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L
I
Q
N
Q
I
R
V
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M
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R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
--
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
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P
R
V
L
V
R
R
K
-
A
G
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V
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S
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V
D
Y
M
D
V
S
P
R
Q
M
V
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V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
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S
E
A
P
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G
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G
M
E
L
R
A
A
I
D
A
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D
V
V
V
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S
G
V
I
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S
A
D
Y
I
T
V
M
H
D
-------
N
-------
G
T
R
R
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R
M
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K
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A
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T
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D
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P
N
I
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D
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V
L
A
D
L
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R
G
I
V
R
I
G
A
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V
R
D
G
D
I
L
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K
V
T
P
K
G
E
T
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L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
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V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
E
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
A
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
C
A
H
S
G
W
K
V
DAAKGVPDWAARLPDELLEA
Q
P
N
A
------------------
I
-------------------------
V
S
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
A
-----------------------------
E
L
Q
G
L
L
--------
S
C
T
L
P
N
RDG
D
--------
V
-----------------------------
L
---
V
D
--------------
A
D
G
K
A
--------------
M
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
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A
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V
K
G
E
N
I
P
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P
G
I
P
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S
F
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V
L
L
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Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
L
R
E
G
E
D
E
-------------------------------------------------
45
PsiBlast_CBE
61.96
58%
23
- C2 -
-
4OIN
3
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
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G
L
A
R
L
A
R
G
V
R
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M
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M
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T
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A
K
L
V
N
S
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P
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A
A
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F
F
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Q
L
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F
K
D
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N
P
L
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S
L
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R
R
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A
L
G
P
G
G
L
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R
A
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F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
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P
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A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
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L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
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V
V
Y
M
T
A
T
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E
D
R
Y
T
I
A
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A
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T
P
L
-
E
G
N
R
I
A
A
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R
V
V
A
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E
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I
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L
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A
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R
I
V
V
R
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-------
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-------
G
R
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P
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A
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A
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A
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F
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R
L
L
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I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
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I
L
P
V
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M
P
H
L
P
D
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T
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D
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I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
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P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
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D
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M
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A
R
S
T
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P
Y
S
L
I
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L
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A
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T
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M
L
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Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
35
PsiBlast_CBE
61.96
58%
24
- C2 -
-
5D4C
1
RPOB_THET8
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
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E
L
M
T
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M
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D
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--
V
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F
D
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Y
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F
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D
A
I
V
I
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E
E
L
L
K
R
D
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Y
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A
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L
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I
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E
A
A
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D
L
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V
R
I
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A
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V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
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L
A
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R
H
G
N
K
G
V
V
A
K
I
L
P
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D
M
P
H
L
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D
G
T
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V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
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S
T
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L
I
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P
L
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G
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A
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F
G
G
Q
R
F
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E
M
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W
A
L
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A
Y
G
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T
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M
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I
E
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A
A
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A
I
I
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G
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V
L
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A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
42
PsiBlast_CBE
61.93
58%
24
- C2 -
-
4OIQ
2
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
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G
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V
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A
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I
G
L
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L
A
A
Y
A
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V
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F
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T
P
Y
R
R
V
--
V
G
G
V
V
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V
Y
M
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A
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Y
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A
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L
-
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R
I
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D
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A
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I
V
V
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V
R
L
R
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R
G
D
P
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V
----------------------------------------------------------------------------------------------------
E
L
K
P
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V
R
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V
V
R
V
Y
V
A
Q
K
R
K
L
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R
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V
V
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L
P
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P
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L
G
V
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R
M
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L
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L
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H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
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E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
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V
L
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A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
25
PsiBlast_CBE
61.93
58%
22
- C2 -
-
5X21
2
?
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
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H
L
G
N
R
R
I
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M
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L
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F
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A
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P
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G
G
I
V
V
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T
V
R
L
R
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R
G
D
P
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V
----------------------------------------------------------------------------------------------------
E
L
K
P
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V
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V
R
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H
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L
A
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Y
-------------------------
F
L
G
Q
------------------
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-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
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Y
F
G
K
R
K
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GFGVD
K
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E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
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Q
L
K
E
L
F
L
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K
V
V
L
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P
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A
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A
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D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
44
PsiBlast_CBE
61.92
58%
22
- C2 -
-
4OIO
4
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
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------------
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D
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L
G
N
R
R
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Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
23
PsiBlast_CBE
61.92
58%
21
- C2 -
-
5X22
1
?
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
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E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
6
PsiBlast_PDB
61.86
62%
44
- C2 -
-
5UH9
3
RPOB_MYCTU
C:
[332-1153]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
------------
T
T
------------
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
--
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
-
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
M
H
D
-------
N
-------
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
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E
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V
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I
H
I
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H
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I
D
A
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D
T
K
L
G
A
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E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
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R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
E
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
A
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
C
A
H
S
G
W
K
V
DAAKGVPDWAARLPDELLEA
Q
P
N
A
------------------
I
-------------------------
V
S
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
A
-----------------------------
E
L
Q
G
L
L
--------
S
C
T
L
P
N
RDG
D
--------
V
-----------------------------
L
---
V
D
--------------
A
D
G
K
A
--------------
M
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
E
P
G
I
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
L
R
E
G
E
D
E
-------------------------------------------------
31
PsiBlast_CBE
61.84
58%
25
- C2 -
-
5E18
2
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
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T
P
E
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A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
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L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
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R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
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E
V
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F
M
D
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T
N
L
I
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A
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R
I
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-------
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A
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V
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A
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L
L
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V
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R
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R
-
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P
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V
----------------------------------------------------------------------------------------------------
E
L
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P
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V
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Y
V
A
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M
N
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G
Q
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T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
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Y
F
G
K
R
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G
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GFGVD
K
R
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V
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V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
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Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
39
PsiBlast_CBE
61.77
58%
24
- C2 -
-
4Q5S
4
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
4
PsiBlast_PDB
61.61
62%
46
- C2 -
-
5UH6
4
RPOB_MYCTU
C:
[332-1153]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
------------
T
T
------------
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
--
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
-
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
M
H
D
-------
N
-------
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
E
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
A
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
C
A
H
S
G
W
K
V
DAAKGVPDWAARLPDELLEA
Q
P
N
A
------------------
I
-------------------------
V
S
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
A
-----------------------------
E
L
Q
G
L
L
--------
S
C
T
L
P
N
RDG
D
--------
V
-----------------------------
L
---
V
D
--------------
A
D
G
K
A
--------------
M
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
E
P
G
I
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
L
R
E
G
E
D
E
-------------------------------------------------
3
PsiBlast_PDB
61.54
62%
45
- C2 -
-
5UH5
3
RPOB_MYCTU
C:
[332-1153]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
------------
T
T
------------
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
--
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
-
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
M
H
D
-------
N
-------
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
E
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
A
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
C
A
H
S
G
W
K
V
DAAKGVPDWAARLPDELLEA
Q
P
N
A
------------------
I
-------------------------
V
S
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
A
-----------------------------
E
L
Q
G
L
L
--------
S
C
T
L
P
N
RDG
D
--------
V
-----------------------------
L
---
V
D
--------------
A
D
G
K
A
--------------
M
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
E
P
G
I
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
L
R
E
G
E
D
E
-------------------------------------------------
7
PsiBlast_PDB
61.50
62%
44
- C2 -
-
5UHA
2
RPOB_MYCTU
C:
[332-1153]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
------------
T
T
------------
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
--
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
-
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
M
H
D
-------
N
-------
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
E
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
A
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
C
A
H
S
G
W
K
V
DAAKGVPDWAARLPDELLEA
Q
P
N
A
------------------
I
-------------------------
V
S
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
A
-----------------------------
E
L
Q
G
L
L
--------
S
C
T
L
P
N
RDG
D
--------
V
-----------------------------
L
---
V
D
--------------
A
D
G
K
A
--------------
M
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
E
P
G
I
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
L
R
E
G
E
D
E
-------------------------------------------------
49
PsiBlast_CBE
61.45
58%
21
- C2 -
-
4G7Z
2
RPOB_THET8
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
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V
V
G
Q
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V
R
K
G
D
L
L
A
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P
A
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N
G
F
L
A
L
G
Q
N
V
L
V
A
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M
P
F
D
G
Y
N
F
E
D
A
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V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
34
PsiBlast_CBE
61.40
58%
25
- C2 -
-
5D4E
4
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
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E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
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E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
GK
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
9
PsiBlast_PDB
61.39
62%
44
- C2 -
-
5UHC
4
RPOB_MYCTU
C:
[332-1153]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
------------
T
T
------------
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
--
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
-
A
G
E
V
E
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V
P
S
S
E
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D
Y
M
D
V
S
P
R
Q
M
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A
T
A
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I
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F
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D
D
A
N
R
A
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A
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M
Q
R
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A
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P
L
V
R
S
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A
P
L
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M
E
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A
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D
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V
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A
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G
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I
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A
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Y
I
T
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M
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D
-------
N
-------
G
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R
R
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M
R
K
F
A
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H
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A
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C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
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Y
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A
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I
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L
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D
I
L
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V
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P
K
G
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L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
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E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
E
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
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E
L
V
R
V
Y
V
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K
R
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I
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D
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R
H
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I
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I
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A
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D
I
I
L
N
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V
P
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R
M
N
I
G
Q
I
L
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T
H
L
G
W
C
A
H
S
G
W
K
V
DAAKGVPDWAARLPDELLEA
Q
P
N
A
------------------
I
-------------------------
V
S
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
A
-----------------------------
E
L
Q
G
L
L
--------
S
C
T
L
P
N
RDG
D
--------
V
-----------------------------
L
---
V
D
--------------
A
D
G
K
A
--------------
M
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
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H
L
V
D
D
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I
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S
T
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Q
P
L
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F
G
G
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F
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C
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A
M
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T
L
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L
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V
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V
L
S
S
D
G
A
A
I
E
L
R
E
G
E
D
E
-------------------------------------------------
26
PsiBlast_CBE
61.36
58%
24
- C2 -
-
5VO8
3
?
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
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------------
D
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N
R
R
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--
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R
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V
----------------------------------------------------------------------------------------------------
E
L
K
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Y
-------------------------
F
L
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Q
------------------
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-------------------------
Y
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P
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------------------------------------------------------
D
G
A
K
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P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
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Y
F
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K
R
K
G
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GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
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Q
L
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L
F
L
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V
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P
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V
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L
A
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D
V
Q
T
L
D
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K
D
N
P
V
D
I
-------------------------------------------------------
10
PsiBlast_PDB
61.36
62%
45
- C2 -
-
5UHD
3
RPOB_MYCTU
C:
[332-1153]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
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PGG
V
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A
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V
I
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I
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V
F
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----------------------------------------------------------------------------------------------------
E
L
P
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V
DAAKGVPDWAARLPDELLEA
Q
P
N
A
------------------
I
-------------------------
V
S
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
A
-----------------------------
E
L
Q
G
L
L
--------
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C
T
L
P
N
RDG
D
--------
V
-----------------------------
L
---
V
D
--------------
A
D
G
K
A
--------------
M
L
F
D
G
R
S
G
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P
F
P
Y
P
V
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V
G
Y
M
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L
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A
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L
R
E
G
E
D
E
-------------------------------------------------
13
PsiBlast_PDB
61.26
62%
44
- C2 -
-
5UHG
4
RPOB_MYCTU
C:
[332-1153]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
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Y
L
V
R
L
H
E
G
Q
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PGG
V
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----------------------------------------------------------------------------------------------------
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K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
A
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
C
A
H
S
G
W
K
V
DAAKGVPDWAARLPDELLEA
Q
P
N
A
------------------
I
-------------------------
V
S
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
A
-----------------------------
E
L
Q
G
L
L
--------
S
C
T
L
P
N
RDG
D
--------
V
-----------------------------
L
---
V
D
--------------
A
D
G
K
A
--------------
M
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
E
P
G
I
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
L
R
E
G
E
D
E
-------------------------------------------------
5
PsiBlast_PDB
61.26
62%
45
- C2 -
-
5UH8
3
RPOB_MYCTU
C:
[332-1153]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
------------
T
T
------------
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
--
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
-
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
M
H
D
-------
N
-------
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
E
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
A
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
C
A
H
S
G
W
K
V
DAAKGVPDWAARLPDELLEA
Q
P
N
A
------------------
I
-------------------------
V
S
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
A
-----------------------------
E
L
Q
G
L
L
--------
S
C
T
L
P
N
RDG
D
--------
V
-----------------------------
L
---
V
D
--------------
A
D
G
K
A
--------------
M
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
E
P
G
I
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
L
R
E
G
E
D
E
-------------------------------------------------
50
PsiBlast_CBE
61.16
58%
21
- C2 -
-
4G7Z
2
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
H
E
----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
F
E
V
Y
F
G
K
R
K
G
E
GFGVD
K
R
E
V
E
V
L
R
R
A
E
K
L
G
---
L
V
--------------
T
P
G
K
T
P
E
E
Q
L
K
E
L
F
L
Q
GK
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
12
PsiBlast_PDB
61.09
62%
44
- C2 -
-
5UHF
3
RPOB_MYCTU
C:
[332-1153]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
Q
------------
T
T
------------
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
--
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
-
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
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D
V
V
V
A
E
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S
G
V
I
E
E
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S
A
D
Y
I
T
V
M
H
D
-------
N
-------
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
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D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
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D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
-
V
I
G
I
R
V
F
-
S
R
E
D
E
D
----------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
A
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
C
A
H
S
G
W
K
V
DAAKGVPDWAARLPDELLEA
Q
P
N
A
------------------
I
-------------------------
V
S
T
P
V
F
------------------------------------------------------
D
G
A
Q
E
A
-----------------------------
E
L
Q
G
L
L
--------
S
C
T
L
P
N
RDG
D
--------
V
-----------------------------
L
---
V
D
--------------
A
D
G
K
A
--------------
M
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
H
H
L
V
D
D
K
I
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A
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P
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M
I
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Q
Q
P
L
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G
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A
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G
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M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
E
P
G
I
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
D
G
A
A
I
E
L
R
E
G
E
D
E
-------------------------------------------------
22
PsiBlast_CBE
60.52
57%
27
- C2 -
-
4XLN
1
?
I:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
A
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
V
M
G
S
P
D
T
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
L
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
A
L
G
F
I
R
T
P
Y
R
R
V
--
K
N
G
V
V
T
E
E
V
V
Y
M
T
A
S
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
D
-
R
I
A
T
D
R
V
V
A
R
R
R
-
G
E
P
V
I
-
V
A
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
L
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
V
K
V
D
G
T
R
I
A
V
R
Y
E
-------
D
-------
G
R
L
V
E
H
P
L
R
R
Y
A
R
S
N
Q
G
T
A
F
D
Q
R
P
R
V
R
V
G
Q
R
V
K
K
G
D
L
L
A
D
G
P
A
S
E
E
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
I
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
Q
E
P
S
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
G
R
L
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
F
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
V
F
------------------------------------------------------
D
G
A
T
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
E
--------
A
FNLYFGKRQGEGFGVDKREKEVLARAEKL
G
---
L
V
--------------
S
P
G
K
S
PEEQLKELFDLGKV
V
L
Y
D
G
R
T
G
E
P
F
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
I
K
S
D
D
I
E
G
R
N
A
A
Y
Q
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
65
PsiBlast_CBE
60.49
58%
25
- C2 -
-
2O5J
4
RPOB_THET8
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
17
PsiBlast_PDB
60.04
57%
27
- C2 -
-
4XLN
1
?
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
A
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
V
M
G
S
P
D
T
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
L
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
A
L
G
F
I
R
T
P
Y
R
R
V
--
K
N
G
V
V
T
E
E
V
V
Y
M
T
A
S
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
D
-
R
I
A
T
D
R
V
V
A
R
R
R
-
G
E
P
V
I
-
V
A
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
L
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
V
K
V
D
G
T
R
I
A
V
R
Y
E
-------
D
-------
G
R
L
V
E
H
P
L
R
R
Y
A
R
S
N
Q
G
T
A
F
D
Q
R
P
R
V
R
V
G
Q
R
V
K
K
G
D
L
L
A
D
G
P
A
S
E
E
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
I
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
Q
E
P
S
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
G
R
L
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
F
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
V
F
------------------------------------------------------
D
G
A
T
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
E
--------
A
FNLYFGKRQGEGFGVDKREKEVLARAEKL
G
---
L
V
--------------
S
P
G
K
S
PEEQLKELFDLGKV
V
L
Y
D
G
R
T
G
E
P
F
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
I
K
S
D
D
I
E
G
R
N
A
A
Y
Q
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
67
PsiBlast_CBE
60.01
58%
24
- C2 -
-
2O5I
3
RPOB_THET8
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
21
PsiBlast_CBE
59.80
57%
26
- C2 -
-
4XLR
1
RPOB_THEAQ
I:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
A
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
V
M
G
S
P
D
T
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
L
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
A
L
G
F
I
R
T
P
Y
R
R
V
--
K
N
G
V
V
T
E
E
V
V
Y
M
T
A
S
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
D
-
R
I
A
T
D
R
V
V
A
R
R
R
-
G
E
P
V
I
-
V
A
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
L
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
V
K
V
D
G
T
R
I
A
V
R
Y
E
-------
D
-------
G
R
L
V
E
H
P
L
R
R
Y
A
R
S
N
Q
G
T
A
F
D
Q
R
P
R
V
R
V
G
Q
R
V
K
K
G
D
L
L
A
D
G
P
A
S
E
E
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
I
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
Q
E
P
S
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
G
R
L
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
F
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
V
F
------------------------------------------------------
D
G
A
T
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
E
--------
A
FNLYFGKRQGEGFGVDKREKEVLARAEKL
G
---
L
V
--------------
S
P
G
K
S
PEEQLKELFDLGKV
V
L
Y
D
G
R
T
G
E
P
F
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
I
K
S
D
D
I
E
G
R
N
A
A
Y
Q
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
62
PsiBlast_CBE
59.61
58%
23
- C2 -
-
3AOH
2
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
68
PsiBlast_CBE
59.52
58%
25
- C2 -
-
2O5I
3
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
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Y
A
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E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
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P
L
R
R
F
Y
R
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N
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G
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A
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R
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V
V
V
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Q
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V
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L
L
A
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A
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N
G
F
L
A
L
G
Q
N
V
L
V
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Y
N
F
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A
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E
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L
L
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F
Y
T
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I
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I
E
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Y
E
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A
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L
G
P
E
R
I
T
R
D
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H
L
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E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
66
PsiBlast_CBE
59.18
58%
29
- C2 -
-
2O5J
4
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
20
PsiBlast_PDB
58.97
57%
25
- C2 -
-
4XLR
1
RPOB_THEAQ
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
A
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
V
M
G
S
P
D
T
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
L
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
A
L
G
F
I
R
T
P
Y
R
R
V
--
K
N
G
V
V
T
E
E
V
V
Y
M
T
A
S
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
D
-
R
I
A
T
D
R
V
V
A
R
R
R
-
G
E
P
V
I
-
V
A
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
L
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
V
K
V
D
G
T
R
I
A
V
R
Y
E
-------
D
-------
G
R
L
V
E
H
P
L
R
R
Y
A
R
S
N
Q
G
T
A
F
D
Q
R
P
R
V
R
V
G
Q
R
V
K
K
G
D
L
L
A
D
G
P
A
S
E
E
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
I
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
Q
E
P
S
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
G
R
L
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
F
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
V
F
------------------------------------------------------
D
G
A
T
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
E
--------
A
FNLYFGKRQGEGFGVDKREKEVLARAEKL
G
---
L
V
--------------
S
P
G
K
S
PEEQLKELFDLGKV
V
L
Y
D
G
R
T
G
E
P
F
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
I
K
S
D
D
I
E
G
R
N
A
A
Y
Q
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
59
PsiBlast_CBE
58.92
58%
24
- C2 -
-
3AOI
2
RPOB_THET8
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
----------------------
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
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S
T
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P
Y
S
L
I
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Q
Q
P
L
G
G
K
A
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F
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G
Q
R
F
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E
M
E
V
W
A
L
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A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
61
PsiBlast_CBE
58.91
58%
26
- C2 -
-
3AOI
2
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
-----------------------
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
37
PsiBlast_CBE
58.79
58%
25
- C2 -
-
4WQS
2
RPOB_THET8
M:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
60
PsiBlast_CBE
58.71
58%
24
- C2 -
-
3AOI
2
RPOB_THET8
H:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
--------------------------
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
38
PsiBlast_CBE
58.63
58%
28
- C2 -
-
4WQS
2
RPOB_THET8
C:
[303-1111]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
------------
P
G
HE----------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
-
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
-------
D
-------
G
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
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V
V
V
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Q
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K
G
D
L
L
A
D
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G
F
L
A
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N
V
L
V
A
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M
P
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Y
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A
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L
L
K
R
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Y
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A
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A
A
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D
L
D
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V
V
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I
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A
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V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
-
R
G
D
P
G
V
----------------------------------------------------------------------------------------------------
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
-------------------------
F
L
G
Q
------------------
R
-------------------------
Y
I
S
P
I
F
------------------------------------------------------
D
G
A
K
E
P
-----------------------------
E
I
K
E
L
L
--------
A
--------
Q
--------
A
FEVYFGKRKGEGFGVDKREVEVLRRAEKL
G
---
L
V
--------------
T
P
G
K
T
PEEQLKELFLQGKV
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
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F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
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F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
-------------------------------------------------------
86
PsiBlast_CBE
44.65
61%
-12
- C2 -
-
5UP6
1
RPOB_ECOLI
I:
[424-938]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
------------
G
E
------------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
--
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
-
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
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L
I
P
F
L
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H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
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P
T
L
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A
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K
P
L
V
G
T
G
M
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R
A
V
A
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A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
EDEMYPG
E
-------
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
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D
S
I
L
V
S
E
R
V
V
Q
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D
R
F
T
T
I
H
I
Q
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D
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L
G
P
E
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A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
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G
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Y
I
G
A
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T
G
G
D
I
L
V
G
K
V
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K
G
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L
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K
L
L
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A
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F
G
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A
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D
V
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D
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S
L
R
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P
N
G
V
S
G
T
-
V
I
D
V
Q
V
F
-
T
R
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
44.53
61%
-11
- C2 -
-
5UPC
1
RPOB_ECOLI
I:
[424-938]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
------------
G
E
------------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
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Q
F
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V
G
L
V
R
V
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R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
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L
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F
M
D
Q
N
N
P
L
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A
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G
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L
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L
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--
D
G
V
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T
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A
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N
Y
V
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A
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-
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L
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D
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V
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A
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A
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M
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A
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P
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V
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M
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R
A
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A
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A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
EDEMYPG
E
-------
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
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V
T
G
G
D
I
L
V
G
K
V
T
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K
G
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K
L
L
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A
I
F
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K
A
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D
V
K
D
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S
L
R
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N
G
V
S
G
T
-
V
I
D
V
Q
V
F
-
T
R
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
44.09
61%
-9
- C2 -
-
5UPA
1
?
I:
[424-938]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
------------
G
E
------------
V
------------
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
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G
L
V
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V
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E
R
L
S
L
G
D
L
D
T
L
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Q
D
M
I
N
A
K
P
I
S
A
A
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K
E
F
F
G
S
S
Q
L
S
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F
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D
Q
N
N
P
L
S
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I
T
H
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A
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G
P
G
G
L
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I
G
L
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L
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--
D
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A
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N
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V
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A
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L
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-
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A
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G
G
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V
I
K
V
N
EDEMYPG
E
-------
A
G
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D
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Y
N
L
T
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Y
T
R
S
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N
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C
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V
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G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------