@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XWB1: (2017-12-29 )
MEAGAFGYIRGGSEDEWTMKENTTSFNTKKIMPRILRGIDSADLHTSVFGIELDTPIIQAPSAAQGLAHEKGEADTAKGVAAAGSIFSISTYANTTIKDAADAAPGAPQFFQLYMSKDDRFNEFILNKAVEAGAKAIILTADSTLGGYREEDVINQFQFPLPMPNLAAYSEQSASGNGEGKGIAEIYAAAKQGLTPDDIKTIKEITHLPVIVKGIQSPEDAVIAISAGADGIWVSNHGGRQLDGGPASFEVLPKIAEVVNKRVPVIFDSGVRRGEHVFKALASGADLVAIGRPVIYGLNLVGQKE
Atome Classification :
(39 SA)
.........10........20........30........40........50........60........70.-........80..--....--.--.90........100..--.....--110.......120.......130.......140.......150.......160....--..--...170-....-...180.-.-.....--190.---.......200.......210.......220.......230.......240.......250.......260---..-----.......270.......280.......290.......300...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEAG
A
F
G
Y
IRGGSEDE
W
T
MKENTTSF
N
T
K
K
I
M
P
R
I
L
R
GIDSADL
H
T
S
V
F
G
I
ELDTPIIQAP
S
A
AQGLAHE-K-GEADTAKGVAAA--G
S
I
F
--
S
--
I
S
TYANTTIKDAADAA--PG
A
P
Q
--
F
F
Q
L
Y
MSKDD
R
F
N
E
F
I
L
N
K
A
V
EAGA
K
A
I
I
L
T
ADSTLGGY
R
E
E
D
V
I
N
Q
FQFP--LPMP--
N
L
--
A
A
YSEQ-SASG-NGEG
K
G
I
-
A
-
E
I
Y
A
A
--
A
-KQ---GL
T
P
D
D
I
K
T
I
K
E
ITH
L
P
V
I
V
K
GIQSPE
D
A
V
I
A
I
SAGA
D
G
I
W
VSNHGGRQLDGGP
A
S
F
E
V
L
P
K
I
A
E
V
V
N-----KR-----V
P
V
I
FDSGVR
R
G
E
H
V
F
K
A
L
ASGA
D
L
V
A
IGR
P
V
I
Y
G
L
N
LVGQKE
34
PsiBlast_CBE
88.03
51%
-64
- C3 -
-
2DU2
1
?
D:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
7
PsiBlast_PDB
88.02
51%
-64
- C3 -
-
4RJE
3
?
A:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
G
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
---
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
28
PsiBlast_CBE
88.00
52%
-63
- C3 -
-
4YL2
2
?
B:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
F
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
31
PsiBlast_CBE
87.59
51%
-63
- C3 -
-
2E77
2
?
D:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
2
PsiBlast_PDB
87.57
52%
-68
- C3 -
-
4YL2
2
?
A:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
F
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
37
PsiBlast_CBE
87.54
51%
-64
- C3 -
-
4RJE
2
?
D:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
G
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
---
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
26
PsiBlast_CBE
87.49
52%
-65
- C3 -
-
4YL2
2
?
D:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
F
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
---
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
41
PsiBlast_CBE
87.38
51%
-69
- C3 -
-
5EBU
2
?
F:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
F
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
35
PsiBlast_CBE
87.33
51%
-65
- C3 -
-
2DU2
1
?
C:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
33
PsiBlast_CBE
87.23
51%
-64
- C3 -
-
2E77
2
?
B:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
45
PsiBlast_CBE
87.20
51%
-67
- C3 -
-
5EBU
2
?
B:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
F
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
36
PsiBlast_CBE
87.06
51%
-67
- C3 -
-
2DU2
1
?
B:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
24
PsiBlast_CBE
86.98
51%
-66
- C3 -
-
2J6X
1
?
C:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
1
PsiBlast_PDB
86.86
51%
-61
- C3 -
-
2J6X
1
?
A:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
4
PsiBlast_PDB
86.81
51%
-61
- C3 -
-
2DU2
1
?
A:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
25
PsiBlast_CBE
86.79
51%
-66
- C3 -
-
2J6X
1
?
B:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
23
PsiBlast_CBE
86.74
51%
-62
- C3 -
-
2J6X
1
?
E:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
8
PsiBlast_PDB
86.63
51%
-65
- C3 -
-
5EBU
2
?
A:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
F
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
27
PsiBlast_CBE
86.39
52%
-66
- C3 -
-
4YL2
2
?
C:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
F
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
38
PsiBlast_CBE
86.23
51%
-61
- C3 -
-
4RJE
3
?
C:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
G
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
---
T
A
E
G
M
S
L
-
N
-
N
------
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
112
HHSearch
85.32
52%
-71
- C3 -
-
2NLI
3
?
A:
[27-325]
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
---
N
R
D
--------
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
L
R
--------
G
T
A
E
G
M
-----
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
--
6
PsiBlast_PDB
84.47
51%
-65
- C3 -
-
2ZFA
2
?
A:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
----------
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
---------
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
3
PsiBlast_PDB
84.12
51%
-68
- C3 -
-
2NLI
3
?
A:
[30-326]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
---
N
R
D
--------
Y
P
--
F
G
M
P
--
I
V
--
Q
R
Y
-----
L
R
G
-
T
A
E
G
M
-------
Y
G
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
30
PsiBlast_CBE
81.81
51%
-79
- C3 -
-
2ZFA
2
?
B:
[36-332]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
-----------------------------------------------------
A
--
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
29
PsiBlast_CBE
80.81
51%
-79
- C3 -
-
2NLI
3
?
B:
[30-326]
---
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
--
S
--
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
--
N
G
G
P
R
--
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
----------------------------------------------------------
S
-
K
Q
---
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
-
10
PsiBlast_PDB
73.24
39%
-3
- C3 -
-
2RDU
2
HAOX1_HUMAN
A:
[41-344]
-----
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
-
D
-
G
E
L
A
T
V
R
A
C
Q
S
L
--
G
T
G
M
--
M
--
L
S
S
W
A
T
S
S
I
E
E
V
A
E
A
G
--
P
E
A
L
R
--
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
K
L
P
PQ
L
R
M
K
--
N
F
ET
S
T
L
S
F
S
-
P
E
E
N
-
F
G
D
D
S
G
L
-
A
-
A
Y
V
A
K
--
A
I
D
P
---
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
-----
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
-
102
HHSearch
71.90
38%
-5
- C3 -
-
2RDU
2
HAOX1_HUMAN
A:
[36-343]
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
-
D
-
G
E
L
A
T
V
R
A
C
Q
S
L
--
G
T
G
M
--
M
--
L
S
S
W
A
T
S
S
I
E
E
V
A
E
A
G
--
P
E
A
L
R
--
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
K
L
P
--
P
Q
L
R
MK
N
F
--
E
T
S
T
L
S
F
S
P
E
E
N
F
G
D
D
S
G
L
-
A
A
Y
V
A
K
A
--
I
-
D
P
---
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
-----
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
--
20
PsiBlast_PDB
65.49
33%
-22
- C3 -
-
2A85
3
GOX_SPIOL
A:
[24-319]
-----
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
L
W
P
-
K
-
G
D
L
A
L
A
R
A
A
T
K
A
--
G
I
P
F
--
V
--
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
--
D
G
-
D
L
--
W
F
Q
L
Y
V
I
H
R
E
I
A
Q
G
M
V
L
-
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
I
P
-----
P
--
F
L
--
T
L
K
N
F
E
-
G
I
D
L
-
G
K
M
D
K
A
N
-
L
-
E
M
Q
A
A
L
M
S
-
R
Q
MDA
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
G
-----
K
-------
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
--
110
HHSearch
59.02
32%
16
- C3 -
-
1KBI
3
CYB2_YEAST
B:
[136-444]
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
-
L
E
G
E
K
D
V
A
R
G
C
G
Q
G
V
T
K
V
P
Q
--
M
--
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
PS
D
K
Q
I
Q
--
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
N
T
----------K-
T
N
V
E
----------
E
S
Q
G
A
S
R
-
A
L
S
K
F
--
I
-
D
P
---
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
NLK
D
K
-----
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
--
74
PsiBlast_CBE
57.40
31%
34
- C3 -
-
1LCO
2
CYB2_YEAST
B:
[140-444]
----
A
W
A
F
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
G
--
V
T
K
V
--
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
--
P
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
----------------------------
Q
G
A
S
R
A
L
-
S
-
K
F
I
D
P
--
S
-------
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
--
79
PsiBlast_CBE
57.12
31%
36
- C3 -
-
1SZF
2
CYB2_YEAST
A:
[140-444]
----
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
G
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
G
--
V
T
K
V
--
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
A
A
--
P
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
N
--------------------------
G
A
S
R
A
L
-
S
-
K
F
I
D
P
--
S
-------
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
--
63
PsiBlast_CBE
56.76
31%
30
* C3 *
-
1KBJ
2
CYB2_YEAST
A:
[41-345]
----
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
G
--
V
T
K
V
P
Q
M
--
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
--
P
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
----------------------------
A
S
R
A
L
-
S
-
K
F
I
D
P
--
S
-------
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
--
68
PsiBlast_CBE
56.59
31%
31
- C3 -
-
1FCB
2
CYB2_YEAST
B:
[140-444]
----
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
G
--
V
T
K
V
--
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
--
P
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
-------------------
N
-
V
E
E
S
-
Q
G
A
S
R
A
L
-
S
-
K
F
I
D
P
--
S
-------
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
--
62
PsiBlast_CBE
56.24
31%
31
- C3 -
-
1KBJ
2
CYB2_YEAST
B:
[41-345]
----
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
G
--
V
T
K
V
P
Q
M
--
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
--
P
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
-----------------------------
A
S
R
A
L
-
S
-
K
F
I
D
P
--
S
-------
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
--
66
PsiBlast_CBE
55.84
31%
35
- C3 -
-
1KBI
3
CYB2_YEAST
B:
[140-444]
----
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
G
--
V
T
K
V
--
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
--
P
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
N
T
---------------
K
T
N
-
V
E
E
S
-
Q
G
A
S
R
A
L
-
S
-
K
F
I
D
P
--
S
-------
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
--
75
PsiBlast_CBE
55.31
31%
36
- C3 -
-
1LCO
3
CYB2_YEAST
A:
[140-444]
----
A
W
A
F
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
G
--
V
T
K
V
--
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
--
P
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
-------------------------------
A
L
-
S
-
K
F
I
D
P
--
S
-------
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
--
72
PsiBlast_CBE
54.92
31%
30
- C3 -
-
1LDC
2
CYB2_YEAST
B:
[140-444]
----
A
W
A
F
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
G
--
V
T
K
V
--
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
--
P
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
---------------------------------------
I
D
P
--
S
-------
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
--
71
PsiBlast_CBE
54.82
31%
39
- C3 -
-
1SZE
2
CYB2_YEAST
A:
[140-444]
----
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
G
--
V
T
K
V
--
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
A
A
--
P
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
-----------------------------
A
S
R
A
L
-
S
-
K
F
I
D
P
--
S
-------
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
--
70
PsiBlast_CBE
53.23
31%
37
- C3 -
-
1SZE
2
CYB2_YEAST
B:
[140-444]
----
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
G
--
V
T
K
V
--
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
A
A
--
P
S
D
K
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
--------------------------------
A
L
-
S
-
K
F
I
D
P
--
S
-------
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
--