@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XWL6: (2017-12-30 )
MSMFLDQVTIDVKAGKGGDGMVAFRREKYVPDGGPAGGDGGRGGDVILIVDEGLRTLMDFRFNRHFKAQPGENGMSKGMHGRGSEDTYVKVPQGTTVRDAETGALLGDLIENGQTLVVAKGGRGGRGNIRFASPRNPAPEIAENGEPGQERKIELELKVLADVGLVGFPSVGKSTLLSVISSARPKIGAYHFTTLVPNLGMVTTSDGRSFAAADLPGLIEGASQGVGLGTQFLRHIERTRVILHVIDMSGMEGRDPYEDYLAINKELSTYNLRLLERPQIIVANKMDMPDAQENLVKFKEQLNKEKEDEFADDIPVFPISGVTRQGLDALLNATADLLEVTPEFPLYEEELEERNCTLWIQSRRS
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.....-----..180...-....190.......200.......210--------------------.......220--..--.---..--..230.----......240....------...250.......260.......270.....--..280.....---..290-..-.......300.....----------..310.-......320.......330.......340---.-......350.......360...--------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
M
F
L
D
Q
V
T
I
D
V
KAGKGGDG
M
V
A
F
R
REKYVPDGGPAGGDGGRGG
D
V
I
L
I
V
D
E
G
L
R
T
L
M
D
F
R
FNRHFKAQPGENGMSKGMHGRGSED
T
Y
V
KVPQGTTVRDA
E
T
G
A
L
L
G
D
L
IENG
Q
T
L
V
V
A
KGGRGGRG
N
I
R
FASPRNPAPEIAENGEPGQ
E
R
K
I
E
L
E
L
K
V
L
A
DVGLVGFPSV
G
K
S
T
L
L
-----
S
V
I
S
SARP-KIG
A
Y
H
F
T
TLVPNL
G
M
V
TTSDGRSF
A
A
--------------------ADL
P
G
L
I
E
GA--SQ--G---
V
G
--
L
G
T
Q
F
L
----
R
H
I
E
R
T
R
V
I
L
H
V
I------DMSGMEGR
D
P
Y
E
D
Y
L
A
I
NKELSTY
N
L
R
L
LER--P
Q
I
I
V
A
NKMD---MP
D
---
A
Q
-
E
N
L
V
K
F
K
E
Q
LNK
E
K
E
----------
D
EFADD-IPVFPIS
G
V
T
R
Q
G
L
D
A
L
L
N
A
T
A
D
L
L
EVTP---E-FPL
Y
E
E
E
L
EERN
C
T
L
W
I
QSRRS--------------------------------------------------------------
35
HHSearch
91.93
74%
-61
- C1 -
-
1LNZ
-
OBG_BACSU
A:
[1-335]
--
M
F
V
D
Q
V
K
V
Y
V
K
G
G
D
G
G
N
G
M
V
A
F
R
R
E
K
Y
V
P
K
G
G
P
A
G
G
D
G
G
K
G
G
D
V
V
F
E
V
D
E
G
L
R
T
L
M
D
F
R
Y
K
K
H
F
K
A
I
R
G
E
H
G
M
S
K
N
Q
H
G
R
N
A
D
D
M
V
I
K
V
P
P
G
T
V
V
T
D
D
D
T
K
Q
V
I
A
D
L
T
E
H
G
Q
R
A
V
I
A
R
G
G
R
G
G
R
G
N
S
R
F
A
T
P
A
N
P
A
P
Q
L
S
E
N
G
E
P
G
K
E
R
Y
I
V
L
E
L
K
V
L
A
D
V
G
L
V
G
F
P
S
V
G
K
S
T
L
L
-----
S
V
V
S
S
A
K
P
-
K
I
A
D
Y
H
F
T
T
L
V
P
N
L
G
M
V
E
T
D
D
G
R
S
F
V
M
--------------------
A
D
L
P
G
L
I
E
G
A
--
H
Q
--
G
---
V
G
--
L
G
H
Q
F
L
----
R
H
I
E
R
T
R
V
I
V
H
V
I
------
D
M
S
G
L
E
G
R
D
P
Y
D
D
Y
L
T
I
N
Q
E
L
S
E
Y
N
L
R
L
T
E
R
--
P
Q
I
I
V
A
N
K
M
D
---
M
P
E
---
A
A
-
E
N
L
E
A
F
K
E
K
----
L
--------------
T
D
D
-
Y
P
V
F
P
I
S
A
V
T
R
E
G
L
R
E
L
L
F
E
V
A
N
Q
L
E
N
T
P
---
E
-
F
P
----------------------------------------------------------------------------------
1
PsiBlast_PDB
90.61
70%
-62
- C1 -
-
1LNZ
-
OBG_BACSU
A:
[2-340]
---
F
V
D
Q
V
K
V
Y
V
K
G
G
D
G
G
N
G
M
V
A
F
R
R
E
K
Y
V
P
K
G
G
P
A
G
G
D
G
G
K
G
G
D
V
V
F
E
V
D
E
G
L
R
T
L
M
D
F
R
Y
K
K
H
F
K
A
I
R
G
E
H
G
M
S
K
N
Q
H
G
R
N
A
D
D
M
V
I
K
V
P
P
G
T
V
V
T
D
D
D
T
K
Q
V
I
A
D
L
T
E
H
G
Q
R
A
V
I
A
R
G
G
R
G
G
R
G
N
S
R
F
A
T
P
A
N
P
A
P
Q
L
S
E
N
G
E
P
G
K
E
R
Y
I
V
L
E
L
K
V
L
A
D
V
G
L
V
G
F
P
S
V
G
K
S
T
L
L
-----
S
V
V
S
S
A
K
P
-
K
I
A
D
Y
H
F
T
T
L
V
P
N
L
G
M
V
E
T
D
D
G
R
S
F
V
M
--------------------
A
D
L
P
G
L
I
E
G
A
--
H
Q
--
G
---
V
G
--
L
G
H
Q
F
L
----
R
H
I
E
R
T
R
V
I
V
H
V
I
------
D
M
S
G
L
E
G
R
D
P
Y
D
D
Y
L
T
I
N
Q
E
L
S
E
Y
N
L
R
L
T
E
R
--
P
Q
I
I
V
A
N
K
M
D
---
M
P
E
---
A
A
-
E
N
L
E
A
F
K
E
K
L
------------------
T
D
D
-
Y
P
V
F
P
I
S
A
V
T
R
E
G
L
R
E
L
L
F
E
V
A
N
Q
L
E
N
T
P
---
E
-
F
P
L
Y
D
E
E
-----------------------------------------------------------------------------
37
HHSearch
89.50
74%
-51
- C1 -
-
1LNZ
1
OBG_BACSU
B:
[1-335]
--
M
F
V
D
Q
V
K
V
Y
V
K
G
G
D
G
G
N
G
M
V
A
F
R
R
E
K
Y
V
P
K
G
G
P
A
G
G
D
G
G
K
G
G
D
V
V
F
E
V
D
E
G
L
R
T
L
M
D
F
R
Y
K
K
H
F
K
A
I
R
G
E
H
G
M
S
K
N
Q
H
G
R
N
A
D
D
M
V
I
K
V
P
P
G
T
V
V
T
D
D
D
T
K
Q
V
I
A
D
L
T
E
H
G
Q
R
A
V
I
A
R
G
G
R
G
G
R
G
N
S
R
F
A
T
P
A
N
P
A
P
Q
L
S
E
N
G
E
P
G
K
E
R
Y
I
V
L
E
L
K
V
L
A
D
V
G
L
V
G
F
P
S
V
G
K
S
T
L
L
-----
S
V
V
S
S
A
K
P
-
K
I
---------
P
N
L
G
M
V
E
T
D
D
G
R
S
F
V
M
--------------------
A
D
L
P
G
L
I
E
G
-----------------
H
Q
F
L
----
R
H
I
E
R
T
R
V
I
V
H
V
I
------
D
M
S
G
L
E
G
R
D
P
Y
D
D
Y
L
T
I
N
Q
E
L
S
E
Y
N
L
R
L
T
E
R
--
P
Q
I
I
V
A
N
K
M
D
---
M
P
E
---
A
A
-
E
N
L
E
A
F
K
E
K
----
L
T
--------------
D
D
-
Y
P
V
F
P
I
S
A
V
T
R
E
G
L
R
E
L
L
F
E
V
A
N
Q
L
E
N
T
P
---
E
-
F
P
----------------------------------------------------------------------------------
25
Fugue
81.90
47%
-60
- C1 -
-
1UDX
1
OBG_THET8
A:
[1-416]
--
M
F
Q
D
V
L
V
I
T
V
A
A
G
R
G
G
D
G
A
V
S
F
R
R
E
K
F
V
P
K
G
G
P
D
G
G
D
G
G
R
G
G
S
V
Y
L
R
A
R
G
S
V
D
S
L
S
R
L
S
-
K
R
T
Y
K
A
E
D
G
E
H
G
R
G
S
Q
Q
H
G
R
G
G
E
D
L
V
I
E
V
P
R
G
T
R
V
F
D
A
D
T
G
E
L
L
A
D
L
T
E
E
G
Q
T
V
L
V
A
R
G
G
A
G
G
R
G
N
M
H
F
V
S
P
T
R
Q
A
P
R
F
A
E
A
G
E
E
G
E
K
R
R
L
R
L
E
L
M
L
I
A
D
V
G
L
V
G
Y
P
N
A
G
K
S
S
L
L
-----
A
A
M
T
R
A
H
P
-
K
I
A
P
Y
P
F
T
T
L
S
P
N
L
G
V
V
E
V
S
E
E
E
R
F
T
L
--------------------
A
D
I
P
G
I
I
E
G
A
--
S
E
--
G
---
K
G
--
L
G
L
E
F
L
----
R
H
I
A
R
T
R
V
L
L
Y
V
L
------
D
A
A
D
----
E
P
L
K
T
L
E
T
L
R
K
E
V
G
A
Y
D
P
A
L
L
R
R
--
P
S
L
V
A
L
N
K
V
D
---
L
L
E
----
E
-
E
A
V
K
A
L
A
D
A
L
A
R
E
G
L
------------------
A
V
L
P
V
S
A
L
T
G
A
G
L
P
A
L
K
E
A
L
H
A
L
V
R
S
T
P
---
P
-
P
E
M
P
K
P
V
P
Q
A
G
V
E
V
V
P
V
A
E
G
V
Y
E
V
R
A
P
E
V
E
R
Y
L
A
R
IKGDLMEA
A
G
Y
L
Q
E
V
F
R
R
Q
G
V
E
A
A
L
R
A
K
GVRAG
D
L
V
R
I
GG
L
E
F
E
YIPEV
39
HHSearch
78.38
49%
-62
- C1 -
-
1UDX
1
OBG_THET8
A:
[1-332]
--
M
F
Q
D
V
L
V
I
T
V
A
A
G
R
G
G
D
G
A
V
S
F
R
R
E
K
F
V
P
K
G
G
P
D
G
G
D
G
G
R
G
G
S
V
Y
L
R
A
R
G
S
V
D
S
L
S
R
L
S
-
K
R
T
Y
K
A
E
D
G
E
H
G
R
G
S
Q
Q
H
G
R
G
G
E
D
L
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I
E
V
P
R
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T
R
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F
D
A
D
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E
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L
A
D
L
T
E
E
G
Q
T
V
L
V
A
R
G
G
A
G
G
R
G
N
M
H
F
V
S
P
T
R
Q
A
P
R
F
A
E
A
G
E
E
G
E
K
R
R
L
R
L
E
L
M
L
I
A
D
V
G
L
V
G
Y
P
N
A
G
K
S
S
L
L
-----
A
A
M
T
R
A
H
P
-
K
I
A
P
Y
P
F
T
T
L
S
P
N
L
G
V
V
E
V
S
E
E
E
R
F
T
L
--------------------
A
D
I
P
G
I
I
E
G
A
--
S
E
--
G
---
K
G
--
L
G
L
E
F
L
----
R
H
I
A
R
T
R
V
L
L
Y
V
L
------
D
A
A
D
----
E
P
L
K
T
L
E
T
L
R
K
E
V
G
A
Y
D
P
A
L
L
R
R
--
P
S
L
V
A
L
N
K
V
D
---
L
L
E
---
E
E
-
A
V
-
K
A
L
A
D
A
----
L
A
----------
R
---
E
G
-
L
A
V
L
P
V
S
A
L
T
G
A
G
L
P
A
L
K
E
A
L
H
A
L
V
R
S
T
P
---
P
-------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.30
48%
-53
- C1 -
-
1UDX
1
OBG_THET8
A:
[1-330]
--
M
F
Q
D
V
L
V
I
T
V
A
A
G
R
G
G
D
G
A
V
S
F
R
R
E
K
F
V
P
K
G
G
P
D
G
G
D
G
G
R
G
G
S
V
Y
L
R
A
R
G
S
V
D
S
L
S
R
L
S
-
K
R
T
Y
K
A
E
D
G
E
H
G
R
G
S
Q
Q
H
G
R
G
G
E
D
L
V
I
E
V
P
R
G
T
R
V
F
D
A
D
T
G
E
L
L
A
D
L
T
E
E
G
Q
T
V
L
V
A
R
G
G
A
G
G
R
G
N
M
H
F
V
S
P
T
R
Q
A
P
R
F
A
E
A
G
E
E
G
E
K
R
R
L
R
L
E
L
M
L
I
A
D
V
G
L
V
G
Y
P
N
A
G
K
S
S
L
L
-----
A
A
M
T
R
A
H
P
-
K
I
A
P
Y
P
F
T
T
L
S
P
N
L
G
V
V
E
V
S
E
E
E
R
F
T
L
--------------------
A
D
I
P
G
I
I
E
G
A
--
S
E
--
G
---
K
G
--
L
G
L
E
F
L
----
R
H
I
A
R
T
R
V
L
L
Y
V
L
------
D
A
A
D
----
E
P
L
K
T
L
E
T
L
R
K
E
V
G
A
Y
D
P
A
L
L
R
R
--
P
S
L
V
A
L
N
K
V
D
---
L
-------------
L
E
E
E
A
V
K
A
L
A
----------
D
A
L
A
R
E
G
L
A
V
L
P
V
S
A
L
T
G
A
G
L
P
A
L
K
E
A
L
H
A
L
V
R
S
T
------------------------------------------------------------------------------------------
36
HHSearch
77.16
46%
-57
- C1 -
-
5M04
1
OBG_ECOLI
A:
[21-357]
-
M
K
F
V
D
E
A
S
I
L
V
V
A
G
D
G
G
N
G
C
V
S
F
R
R
E
K
Y
I
P
K
G
G
P
D
G
G
D
G
G
D
G
G
D
V
W
M
E
A
D
E
N
L
N
T
L
I
D
Y
R
F
E
K
S
F
R
A
E
R
G
Q
N
G
A
S
R
D
C
T
G
K
R
G
K
D
V
T
I
K
V
P
V
G
T
R
V
I
D
Q
G
T
G
E
T
M
G
D
M
T
K
H
G
Q
R
L
L
V
A
K
G
G
W
H
G
L
G
N
T
R
F
K
S
----
T
P
R
Q
K
T
N
G
T
P
G
D
K
R
E
L
L
L
E
L
M
L
L
A
D
V
G
M
L
G
M
P
N
A
G
K
S
T
F
I
-----
R
A
V
S
A
A
K
P
-
K
V
A
D
Y
P
F
T
T
L
V
P
S
L
G
V
V
R
M
D
N
E
K
S
F
V
V
--------------------
A
D
I
P
G
L
I
E
G
A
--
A
E
--
G
---
A
G
--
L
G
I
R
F
L
----
K
H
L
E
R
C
R
V
L
L
H
L
I
------
D
I
D
P
I
D
G
T
D
P
V
E
N
A
R
I
I
I
S
E
L
E
K
Y
S
Q
D
L
A
T
K
--
P
R
W
L
V
F
N
K
I
D
---
L
L
D
---
K
V
-
E
A
E
E
K
A
----
K
A
I
A
E
----------
A
-
L
G
W
E
-
D
K
Y
Y
L
I
S
A
A
S
G
L
G
V
K
D
L
C
W
D
V
M
T
F
I
I
E
N
P
---
V
-------------------------------------------------------------------------------------
2
PsiBlast_PDB
70.71
49%
-40
- C1 -
-
5M04
1
OBG_ECOLI
A:
[23-327]
---
F
V
D
E
A
S
I
L
V
V
A
G
D
G
G
N
G
C
V
S
F
R
R
E
K
Y
I
P
K
G
G
P
D
G
G
D
G
G
D
G
G
D
V
W
M
E
A
D
E
N
L
N
T
L
I
D
Y
R
F
E
K
S
F
R
A
E
R
G
Q
N
G
A
S
R
D
C
T
G
K
R
G
K
D
V
T
I
K
V
P
V
G
T
R
V
I
D
Q
G
T
G
E
T
M
G
D
M
T
K
H
G
Q
R
L
L
V
A
K
G
G
W
H
G
L
G
N
T
R
F
K
S
----
T
P
R
Q
K
T
N
G
T
P
G
D
K
R
E
L
L
L
E
L
M
L
L
A
D
V
G
M
L
G
M
P
N
A
G
K
S
T
F
I
-----
R
A
V
S
A
A
K
P
-
K
V
A
D
Y
P
F
T
T
L
V
P
S
L
G
V
V
R
M
D
N
E
K
S
F
V
V
--------------------
A
D
I
P
G
L
I
E
G
A
--
A
E
--
G
---
A
G
--
L
G
I
R
F
L
----
K
H
L
E
R
C
R
V
L
L
H
L
I
------
D
I
D
P
I
D
G
T
D
P
V
E
N
A
R
I
I
I
S
E
L
E
K
Y
S
Q
D
L
A
T
K
--
P
R
W
L
V
F
N
K
I
D
---
L
L
D
K
V
E
A
E
-
E
K
A
K
A
I
A
E
A
L
G
W
E
-----------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
52.13
24%
-93
- C1 -
-
2FA9
1
SAR1B_CRIGR
B:
[15-188]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
G
K
L
V
F
L
G
L
D
N
A
G
K
T
T
L
L
-----
H
M
L
K
------------
P
T
L
H
P
T
S
E
E
L
T
I
A
-
G
M
T
F
T
T
--------------------
F
D
L
G
G
G
I
------
Q
--
A
---
R
R
--
V
W
K
N
Y
L
----
P
---
A
I
N
G
I
V
F
L
V
------
D
C
A
D
---
H
E
R
L
L
E
S
K
E
E
L
D
S
L
M
T
D
-
E
T
I
A
N
V
--
P
I
L
I
L
G
N
K
I
D
---
R
P
E
---
A
I
-
S
E
-
E
R
L
R
E
M
F
G
L
Y
G
Q
TTGKGSVSLK
E
L
N
A
R
P
-
L
E
V
F
M
C
S
V
L
K
R
Q
G
Y
G
E
G
F
R
W
M
A
Q
Y
I
---------------------------------------------------------------------------------------------
53
HHSearch
51.95
19%
-116
- C1 -
-
1O3Y
1
ARF1_MOUSE
B:
[3-164]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
I
L
M
V
G
L
D
A
A
G
K
T
T
I
L
-----
Y
K
L
K
L
G
E
I
-
V
-
T
T
I
--
P
T
I
G
F
N
V
E
T
V
E
Y
K
-
N
I
S
F
T
V
--------------------
W
D
V
G
G
L
D
------
K
--
I
---
R
P
--
L
W
R
H
Y
F
----
Q
---
N
T
Q
G
L
I
F
V
V
------
D
S
N
D
---
R
E
R
V
N
E
A
R
E
E
L
M
R
M
L
A
E
D
-
E
L
R
D
A
--
V
L
L
V
F
A
N
K
Q
D
---
L
P
N
---
A
M
-
N
A
-
A
E
I
T
D
K
L
G
L
H
S
L
------------
R
H
R
N
-
W
Y
I
Q
A
T
C
A
T
S
G
D
G
L
Y
E
G
L
D
W
L
S
N
Q
L
R
N
-------------------------------------------------------------------------------------------
45
HHSearch
51.03
25%
-32
- C1 -
-
3IEV
1
ERA_AQUAE
A:
[11-185]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
-----
N
N
L
L
G
T
K
V
S
I
I
S
P
K
A
G
T
T
R
M
R
V
L
G
V
K
N
I
P
N
E
A
Q
I
I
F
--------------------
L
D
T
P
G
I
Y
E
P
K
--
K
S
--
D
V
L
G
H
S
--
M
V
E
I
A
K
----
Q
S
L
E
E
A
D
V
I
L
F
M
I
------
D
A
T
E
---
G
W
R
P
R
D
E
E
I
Y
Q
N
F
I
K
P
-----
L
N
K
--
P
V
I
V
V
I
N
K
I
D
---
K
I
G
---
P
A
-
K
N
V
L
P
L
I
D
E
I
H
K
K
--------------
H
P
E
L
-
T
E
I
V
P
I
S
A
L
K
G
A
N
L
D
E
L
V
K
T
I
L
K
Y
L
P
E
G
E
---
P
-------------------------------------------------------------------------------------
29
Fugue
48.82
15%
-81
- C1 -
-
1PUI
-
ENGB_ECOLI
A:
[11-198]
------------------------------------------------------------------------------------------------------------------------------------------------
F
V
M
S
A
P
D
I
R
H
L
P
S
D
T
G
I
E
V
A
F
A
G
R
S
N
A
G
K
S
S
A
L
-----
N
T
L
T
N
Q
Q
L
-----
I
N
L
F
E
V
A
D
G
K
R
L
V
D
-------------------------------
L
P
G
Y
G
E
M
K
--
R
K
--
W
---
Q
R
--
A
L
G
E
Y
L
----
E
K
R
Q
S
L
Q
G
L
V
V
L
M
------
D
I
R
----
H
P
L
K
D
L
D
Q
Q
M
I
E
W
A
V
D
S
N
I
-------
A
V
L
V
L
L
T
K
A
D
KLA
S
G
A
---
R
K
-
A
Q
L
N
M
V
R
E
A
V
L
A
F
N
---------------
G
D
-
V
Q
V
E
T
F
S
S
L
K
K
Q
G
V
D
K
L
R
Q
K
L
D
T
W
F
S
--------------------------------------------------------------------------------------------
46
HHSearch
48.48
25%
-26
* C1 *
-
3R9X
3
ERA_AQUAE
A:
[10-184]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
-----
N
N
L
L
G
T
K
V
S
I
I
S
P
K
A
G
T
T
R
M
R
V
L
G
V
K
N
I
P
N
E
A
Q
I
I
F
--------------------
L
D
T
P
G
I
Y
E
P
K
--
K
S
--
D
V
L
G
H
S
--
M
V
E
I
A
K
----
Q
S
L
E
E
A
D
V
I
L
F
M
I
------
D
A
T
E
---
G
W
R
P
R
D
E
E
I
Y
Q
N
F
I
K
P
-----
L
N
K
--
P
V
I
V
V
I
N
K
I
D
---
K
I
G
---
P
A
-
K
N
V
L
P
L
I
D
E
I
H
K
K
--------------
H
P
E
L
-
T
E
I
V
P
I
S
A
L
K
G
A
N
L
D
E
L
V
K
T
I
L
K
Y
L
P
E
G
E
---
P
-------------------------------------------------------------------------------------
32
Fugue
44.47
21%
-88
- C1 -
-
1M2O
1
SAR1_YEAST
B:
[24-190]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
L
F
L
G
L
D
N
A
G
K
T
T
L
L
-----
H
M
L
K
N
D
R
L
-
A
---
T
L
Q
P
T
W
H
P
T
S
E
E
L
A
I
-
G
N
I
K
F
T
T
--------------------
F
D
L
G
G
-----------
H
---
I
Q
--
A
R
R
L
W
K
----
D
Y
F
P
E
V
N
G
I
V
F
L
V
------
D
A
A
D
P
E
R
F
D
E
A
R
V
E
L
D
A
L
F
N
----
I
A
E
L
K
D
V
--
P
F
V
I
L
G
N
K
I
D
---
A
P
N
---
A
V
S
E
A
E
L
R
S
A
L
G
L
L
N
T
T
G
----------
I
E
G
Q
R
P
-
V
E
V
F
M
C
S
V
V
M
R
N
G
Y
L
E
A
F
Q
W
L
S
Q
Y
I
---------------------------------------------------------------------------------------------
49
HHSearch
43.42
21%
-65
- C1 -
-
1EGA
-
ERA_ECOLI
B:
[8-177]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
F
I
A
I
V
G
R
P
N
V
G
K
S
T
L
L
-----
N
K
L
L
G
Q
K
I
S
I
T
S
R
K
A
Q
T
T
R
H
R
I
V
G
I
H
T
E
G
-
A
Y
Q
A
I
Y
--------------------
V
D
T
P
G
L
H
M
E
E
--
K
R
AI
N
---
R
L
--
M
N
K
A
A
S
----
S
S
I
G
D
V
E
L
V
I
F
V
V
------
E
G
T
R
W
---
T
--
P
D
D
E
M
V
L
N
K
L
R
E
-----
G
K
A
--
P
V
I
L
A
V
N
K
V
D
---
N
V
Q
---
E
K
-
A
D
L
L
P
H
L
Q
F
L
A
S
Q
---------------
M
N
F
-
L
D
I
V
P
I
S
A
E
T
G
L
N
V
D
T
I
A
A
I
V
R
K
H
L
P
E
A
T
-----------------------------------------------------------------------------------------
47
HHSearch
42.72
23%
-18
- C1 -
-
3B1V
1
?
A:
[4-164]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
A
L
I
G
N
P
N
S
G
K
T
S
L
F
-----
N
L
I
T
G
H
N
Q
-
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
L
V
K
-
K
-
N
K
D
L
E
I
--------------------
Q
D
L
P
G
I
Y
S
M
S
--
P
Y
S
P
E
---
A
K
--
V
A
R
D
Y
L
----
L
-
S
Q
R
A
D
S
I
L
N
V
V
------
D
A
T
N
---
L
E
R
N
---
L
Y
L
T
T
Q
L
I
E
-----
T
G
I
--
P
V
T
I
A
L
N
M
I
D
---
V
L
D
---
G
Q
-
G
K
K
I
N
-
V
D
K
L
S
Y
-------------
H
---
L
G
-
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
-------------------------------------------------------------------------------------------
20
PsiBlast_PDB
42.24
24%
-9
- C1 -
-
3B1V
1
?
A:
[3-179]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
E
I
A
L
I
G
N
P
N
S
G
K
T
S
L
F
-----
N
L
I
T
G
H
N
Q
-
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
L
V
--
K
K
N
K
D
L
E
I
--------------------
Q
D
L
P
G
I
Y
S
M
S
PY
S
P
--
E
---
A
K
--
V
A
R
D
Y
L
----
L
S
-
Q
R
A
D
S
I
L
N
V
V
------
D
A
T
N
L
E
-
R
N
L
Y
---------
L
T
T
---
Q
L
I
E
T
GI
P
V
T
I
A
L
N
M
I
D
---
V
L
D
---
G
Q
-------
G
K
K
I
N
V
D
K
L
-----------
S
Y
H
L
G
-
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
D
L
A
-
F
P
I
Y
D
D
R
L
E
---------------------------------------------------------------------------
27
Fugue
41.97
18%
-32
- C1 -
-
1EGA
-
ERA_ECOLI
A:
[4-182]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
S
Y
C
G
F
I
A
I
V
G
R
P
N
V
G
K
S
T
L
L
-----
N
K
L
L
G
Q
K
I
-
S
I
T
S
R
K
A
Q
T
T
R
H
R
I
V
G
I
H
T
E
G
A
Y
Q
A
I
Y
--------------------
V
D
T
P
G
L
H
M
E
E
--
K
R
--
A
---
I
N
R
L
M
N
K
A
A
S
----
S
S
I
G
D
V
E
L
V
I
F
V
V
------
E
G
T
R
W
T
P
D
D
E
M
V
L
N
K
L
R
E
G
K
----------
A
--
P
V
I
L
A
V
N
K
V
D
---
N
V
Q
---
E
K
-
A
D
L
L
P
H
L
Q
F
L
A
S
Q
M
N
----------
F
L
------
D
I
V
P
I
S
A
E
T
G
L
N
V
D
T
I
A
A
I
V
R
K
H
L
P
E
A
T
---
H
-
H
F
P
E
--------------------------------------------------------------------------------
19
PsiBlast_PDB
41.96
24%
-7
- C1 -
-
3B1X
1
?
A:
[3-179]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
E
I
A
L
I
G
N
P
N
S
G
K
T
S
L
F
-----
N
L
I
T
G
H
N
Q
-
R
V
G
N
W
P
G
V
T
V
E
R
K
S
G
L
V
--
K
K
N
K
D
L
E
I
--------------------
Q
D
L
P
G
I
Y
S
M
S
PY
S
P
--
A
---
E
K
--
V
A
R
D
Y
L
----
L
S
-
Q
R
A
D
S
I
L
N
V
V
------
D
A
T
N
L
E
-
R
N
L
Y
---------
L
T
T
---
Q
L
I
E
T
GI
P
V
T
I
A
L
N
M
I
D
---
V
L
D
---
G
Q
-------
G
K
K
I
N
V
D
K
L
-----------
S
Y
H
L
G
-
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
D
L
A
-
F
P
I
Y
D
D
R
L
E
---------------------------------------------------------------------------
15
PsiBlast_PDB
41.27
29%
56
- C1 -
-
3R9X
3
ERA_AQUAE
A:
[12-190]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
-
K
A
G
----
T
T
R
M
R
V
L
G
V
K
N
I
P
N
E
A
Q
I
I
F
--------------------
L
D
T
P
G
I
Y
E
P
K
--
K
S
--
D
---
V
---
L
G
H
S
M
V
E
I
A
K
Q
S
L
E
E
A
D
V
I
L
F
M
I
------
D
A
T
--
E
G
W
R
P
R
D
E
------
E
I
Y
Q
N
F
I
K
P
L
N
K
--
P
V
I
V
V
I
N
K
I
D
---
K
I
G
---
P
A
-
K
N
V
L
P
L
I
D
E
I
H
K
-
K
H
----------
P
E
L
T
E
----
I
V
P
I
S
A
L
K
G
A
N
L
D
E
L
V
K
T
---
I
L
K
Y
L
P
---
E
G
E
P
L
F
P
E
D
M
----------------------------------------------------------------------------
4
PsiBlast_PDB
29.42
35%
-57
- C1 -
-
2DBY
3
?
A:
[4-145]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
I
V
G
L
P
N
V
G
K
S
T
L
F
-----
N
A
L
T
R
A
N
A
-
L
A
A
N
Y
P
F
A
T
I
D
K
N
V
G
V
V
P
L
E
D
E
R
L
Y
A
L
Q
R
T
F
AKGE
R
V
P
P
V
V
P
T
H
V
E
F
V
D
I
A
G
L
V
K
G
A
--
H
K
--
G
---
E
G
--
L
G
N
Q
F
L
----
A
H
I
R
E
V
A
A
I
A
H
V
L
R
CFPD
P
----------
L
E
D
A
E
V
V
E
T
E
L
L
L
A
D
L
A
T
L
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------