@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XWL8: (2017-12-30 )
MVERHLFTSESVSEGHPDKIADQISDAILDAILKQDPTARVACETSVTTGLVLVFGEISTTAYVDIQKVVRETIKEIGYTRAKFGFDGDTAAVLVAIDEQSPDIAQGVDEALEIRDEDKKDVLDEIGAGDQGLMFGFAVDETPELMPLPIALSHRLVRRLADLRKSNELTYLRPDAKSQVTVEYDDQGQPERVDTIVISTQHDDAVDNETIRHDVIEKVVKEVIPAELLDDQTKYYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSASYAARYIAKNIVAAGLARKAEVQLAYAIGVAQPVSISINTFGTGTVPEEELIAAVRENFDLRPAGIIEMLDLRRPIYKQTAAYGHFGRTDVDLPWEHTDKVDALKASLAK
Atome Classification :
(37 SA)
.........10........20........30........40........50........60.---.......70........80........90........100.......110.......120.......130.......140.......150.......160...---..---..170.......180..-..---.---..---190.......200.......-210---.........220.....---.-.230-........240.......250.......260.......270.......280.......290.......300.......310.......320.......330--.......340.......350.......360.......370.......380.......390.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVERHLFTSESVSEGH
P
D
K
I
A
D
Q
I
S
D
A
I
L
D
A
I
L
KQDPT
A
R
V
A
C
ETSV
T
T
G
L
V
L
V
F
GEIS
T
T
A
---
Y
V
D
I
Q
K
V
V
R
E
T
I
K
E
IGYT
R
A
KFGFDGD
T
A
A
V
L
V
A
IDEQS
P
D
I
A
Q
G
V
D
E
A
L
E
IRDE
D
K
K
D
V
L
D
EIGAGDQG
L
M
F
G
F
AVDETPELMPL
P
I
A
L
S
H
R
L
V
R
R
L
A
D
L
R
K---SN---E
L
T
Y
LRPDAK
S
Q
V
T
V
E
Y-DD---Q---GQ---P
E
R
V
D
T
I
V
I
STQHDDAVD
N
E
-
T
-----
I
R
H
D
V
I
E
K
V
V
K
E
VI
P
A
E
---L-LD-D-Q
T
K
Y
Y
INPTG
R
F
V
I
GGPQGDAGLTG
R
K
I
I
V
DTYGGYARHGGGAFSGKDATKVD
R
S
A
S
Y
A
A
R
Y
I
A
K
N
I
V
A
A
GLAR
K
A
E
V
Q
L
A
Y
A
IGVA
Q
P
V
S
I
S
I
NTFGTGT--V
P
E
E
E
L
I
A
A
V
R
ENFDLR
P
A
G
I
I
E
M
L
D
LR
R
P
I
Y
K
Q
TAAYGHFGRTDVDLPWEHTD
K
V
D
A
L
K
A
S
LAK
22
PsiBlast_CBE
77.17
64%
-64
- C4 -
-
1RG9
2
METK_ECOLI
C:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
2
PsiBlast_PDB
76.99
64%
-63
- C4 -
-
1P7L
2
METK_ECOLI
A:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
80
HHSearch
76.85
65%
-63
- C4 -
-
1RG9
2
METK_ECOLI
A:
[2-382]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
D
----------
P
L
E
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
6
PsiBlast_PDB
76.84
64%
-70
- C4 -
-
1MXC
1
METK_ECOLI
A:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
24
PsiBlast_CBE
76.78
64%
-64
- C4 -
-
1P7L
2
METK_ECOLI
D:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
21
PsiBlast_CBE
76.73
64%
-64
- C4 -
-
1RG9
2
METK_ECOLI
D:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
25
PsiBlast_CBE
76.72
64%
-62
- C4 -
-
1P7L
2
METK_ECOLI
C:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
3
PsiBlast_PDB
76.42
64%
-63
- C4 -
-
1RG9
2
METK_ECOLI
A:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
5
PsiBlast_PDB
76.34
64%
-68
- C4 -
-
1MXB
1
METK_ECOLI
A:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
26
PsiBlast_CBE
76.22
64%
-63
- C4 -
-
1P7L
2
METK_ECOLI
B:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
7
PsiBlast_PDB
76.18
64%
-66
- C4 -
-
1XRA
-
METK_ECOLI
A:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
23
PsiBlast_CBE
75.95
64%
-63
- C4 -
-
1RG9
2
METK_ECOLI
B:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
13
PsiBlast_PDB
75.93
63%
-69
- C4 -
-
1XRB
-
METK_ECOLI
A:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
4
PsiBlast_PDB
75.78
64%
-67
- C4 -
-
1MXA
1
METK_ECOLI
A:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
8
PsiBlast_PDB
75.75
64%
-67
- C4 -
-
1XRC
-
METK_ECOLI
A:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
72
HHSearch
74.35
64%
-27
- C4 -
-
5H9U
-
METK_THET2
A:
[19-412]
M
R
A
L
R
L
V
T
S
E
S
V
T
E
G
H
P
D
K
L
A
D
R
I
S
D
A
I
L
D
A
L
I
A
Q
D
K
K
A
R
V
A
A
E
T
L
V
T
T
G
L
V
F
V
A
G
E
I
T
T
E
G
---
Y
V
D
I
P
N
L
V
R
K
T
V
R
E
V
G
Y
T
R
A
K
Y
G
F
D
A
D
T
C
A
V
L
T
A
I
D
E
Q
S
P
D
I
A
G
G
V
N
L
S
Y
E
W
R
V
L
K
S
T
D
P
L
D
R
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
P
E
L
M
P
L
P
I
T
L
A
H
R
L
T
M
R
L
A
E
V
R
K
---
T
G
---
L
L
P
Y
L
R
P
D
G
K
A
Q
V
T
V
V
Y
-
E
G
-------
D
K
---
P
L
Y
V
K
T
V
V
V
S
A
Q
H
S
P
E
V
E
Q
E
-
Q
-----
L
R
E
D
L
I
R
E
V
V
R
Q
A
I
P
P
E
---
Y
L
K
D
-
G
-
E
T
E
Y
L
I
N
P
S
G
R
F
I
L
G
G
P
H
A
D
T
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
V
P
H
G
G
G
A
F
S
G
K
D
P
T
K
V
D
R
S
A
S
Y
Y
A
R
Y
M
A
K
N
I
V
A
A
G
L
A
R
R
A
L
V
E
L
A
Y
A
I
G
K
A
R
P
V
S
L
R
V
E
T
F
G
T
G
V
--
L
P
D
E
K
L
T
E
I
A
K
K
V
F
D
P
R
P
L
A
I
I
E
E
L
D
L
L
R
P
I
Y
T
P
T
S
A
Y
G
H
F
G
R
P
--
G
F
P
W
E
E
T
D
R
V
E
A
L
R
R
E
A
G
-
1
PsiBlast_PDB
74.23
64%
-71
- C4 -
-
1FUG
-
METK_ECOLI
A:
[2-377]
---
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
-
D
D
-------
G
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
K
-
S
-----
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
9
PsiBlast_PDB
74.04
64%
-30
- C4 -
-
5H9U
-
METK_THET2
C:
[19-408]
M
R
A
L
R
L
V
T
S
E
S
V
T
E
G
H
P
D
K
L
A
D
R
I
S
D
A
I
L
D
A
L
I
A
Q
D
K
K
A
R
V
A
A
E
T
L
V
T
T
G
L
V
F
V
A
G
E
I
T
T
E
G
---
Y
V
D
I
P
N
L
V
R
K
T
V
R
E
V
G
Y
T
R
A
K
Y
G
F
D
A
D
T
C
A
V
L
T
A
I
D
E
Q
S
P
D
I
A
G
G
V
N
L
S
Y
E
W
R
V
L
K
S
T
D
P
L
D
R
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
P
E
L
M
P
L
P
I
T
L
A
H
R
L
T
M
R
L
A
E
V
R
K
---
T
G
---
L
L
P
Y
L
R
P
D
G
K
A
Q
V
T
V
V
Y
-
E
G
---
D
----
K
---
P
L
Y
V
K
T
V
V
V
S
A
Q
H
S
P
E
V
E
Q
E
-
Q
-----
L
R
E
D
L
I
R
E
V
V
R
Q
A
I
P
P
E
---
Y
-
L
K
-
D
G
E
T
E
Y
L
I
N
P
S
G
R
F
I
L
G
G
P
H
A
D
T
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
V
P
H
G
G
G
A
F
S
G
K
D
P
T
K
V
D
R
S
A
S
Y
Y
A
R
Y
M
A
K
N
I
V
A
A
G
L
A
R
R
A
L
V
E
L
A
Y
A
I
G
K
A
R
P
V
S
L
R
V
E
T
F
G
T
G
V
--
L
P
D
E
K
L
T
E
I
A
K
K
V
F
D
P
R
P
L
A
I
I
E
E
L
D
L
L
R
P
I
Y
T
P
T
S
A
Y
G
H
F
G
R
P
--
G
F
P
W
E
E
T
D
R
V
E
A
L
R
-----
28
PsiBlast_CBE
73.94
64%
-19
- C4 -
-
5T8S
3
METK_NEIG1
B:
[10-394]
--
S
E
Y
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
V
S
D
A
I
L
D
A
I
L
A
Q
D
P
K
A
R
V
A
A
E
T
L
V
N
T
G
L
C
V
L
A
G
E
I
T
T
T
A
---
Q
V
D
Y
I
K
V
A
R
E
T
I
K
R
I
G
Y
N
S
S
E
L
G
F
D
A
N
G
C
A
V
G
V
Y
Y
D
Q
Q
S
P
------------
D
-------
L
N
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
T
L
M
P
F
A
I
Y
Y
S
H
R
L
M
Q
R
Q
S
E
L
R
K
---
D
G
---
R
L
P
W
L
R
P
D
A
K
A
Q
L
T
V
V
Y
-
D
S
---
E
T--
G
K
---
V
K
R
I
D
T
V
V
L
S
T
Q
H
D
P
A
I
S
Q
E
-
E
-----
L
S
K
A
V
I
E
Q
I
I
K
P
V
L
P
P
E
---
L
-
L
T
-
D
-
E
T
K
Y
L
I
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
C
R
Y
V
A
K
N
I
V
A
A
G
L
A
T
Q
C
Q
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
S
I
D
T
F
G
T
G
K
--
I
S
E
E
K
L
I
A
L
V
C
E
H
F
D
L
R
P
K
G
I
V
Q
M
L
D
L
L
R
P
I
Y
G
K
S
A
A
Y
G
H
F
G
R
E
E
P
E
F
T
W
E
R
T
D
K
A
A
S
L
K
A
A
---
27
PsiBlast_CBE
73.71
64%
-22
- C4 -
-
5T8T
1
METK_NEIG1
B:
[10-394]
--
S
E
Y
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
V
S
D
A
I
L
D
A
I
L
A
Q
D
P
K
A
R
V
A
A
E
T
L
V
N
T
G
L
C
V
L
A
G
E
I
T
T
T
A
---
Q
V
D
Y
I
K
V
A
R
E
T
I
K
R
I
G
Y
N
S
S
E
L
G
F
D
A
N
G
C
A
V
G
V
Y
Y
D
Q
Q
S
P
------------
D
-------
L
N
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
T
L
M
P
F
A
I
Y
Y
S
H
R
L
M
Q
R
Q
S
E
L
R
K
---
D
G
---
R
L
P
W
L
R
P
D
A
K
A
Q
L
T
V
V
Y
-
D
S
---
E
T--
G
K
---
V
K
R
I
D
T
V
V
L
S
T
Q
H
D
P
A
I
S
Q
E
-
E
-----
L
S
K
A
V
I
E
Q
I
I
K
P
V
L
P
P
E
---
L
-
L
T
-
D
-
E
T
K
Y
L
I
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
C
R
Y
V
A
K
N
I
V
A
A
G
L
A
T
Q
C
Q
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
S
I
D
T
F
G
T
G
K
--
I
S
E
E
K
L
I
A
L
V
C
E
H
F
D
L
R
P
K
G
I
V
Q
M
L
D
L
L
R
P
I
Y
G
K
S
A
A
Y
G
H
F
G
R
E
E
P
E
F
T
W
E
R
T
D
K
A
A
S
L
K
A
A
---
79
HHSearch
73.44
65%
-11
- C4 -
-
5T8S
3
METK_NEIG1
A:
[10-397]
--
S
E
Y
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
V
S
D
A
I
L
D
A
I
L
A
Q
D
P
K
A
R
V
A
A
E
T
L
V
N
T
G
L
C
V
L
A
G
E
I
T
T
T
A
---
Q
V
D
Y
I
K
V
A
R
E
T
I
K
R
I
G
Y
N
S
S
E
L
G
F
D
A
N
G
C
A
V
G
V
Y
Y
D
Q
Q
S
P
D
I
A
Q
G
V
N
E
G
E
G
--------
I
D
L
N
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
T
L
M
P
F
A
I
Y
Y
S
H
R
L
M
Q
R
Q
S
E
L
R
K
---
D
G
---
R
L
P
W
L
R
P
D
A
K
A
Q
L
T
V
V
Y
-
D
S
---
E
T--
G
K
---
V
K
R
I
D
T
V
V
L
S
T
Q
H
D
P
A
I
S
Q
E
-
E
-----
L
S
K
A
V
I
E
Q
I
I
K
P
V
L
P
P
E
---
L
-
L
T
-
D
-
E
T
K
Y
L
I
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
C
R
Y
V
A
K
N
I
V
A
A
G
L
A
T
Q
C
Q
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
S
I
D
T
F
G
T
G
K
--
I
S
E
E
K
L
I
A
L
V
C
E
H
F
D
L
R
P
K
G
I
V
Q
M
L
D
L
L
R
P
I
Y
G
K
S
A
A
Y
G
H
F
G
R
E
E
P
E
F
T
W
E
R
T
D
K
A
A
S
L
K
A
A
A
G
L
10
PsiBlast_PDB
72.50
64%
-9
- C4 -
-
5T8S
3
METK_NEIG1
A:
[10-394]
--
S
E
Y
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
V
S
D
A
I
L
D
A
I
L
A
Q
D
P
K
A
R
V
A
A
E
T
L
V
N
T
G
L
C
V
L
A
G
E
I
T
T
T
A
---
Q
V
D
Y
I
K
V
A
R
E
T
I
K
R
I
G
Y
N
S
S
E
L
G
F
D
A
N
G
C
A
V
G
V
Y
Y
D
Q
Q
S
P
D
I
A
Q
G
V
N
E
G
E
G
I
D
-------
L
N
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
T
L
M
P
F
A
I
Y
Y
S
H
R
L
M
Q
R
Q
S
E
L
R
K
---
D
G
---
R
L
P
W
L
R
P
D
A
K
A
Q
L
T
V
V
Y
-
D
S
---
E
T--
G
K
---
V
K
R
I
D
T
V
V
L
S
T
Q
H
D
P
A
I
S
Q
E
-
E
-----
L
S
K
A
V
I
E
Q
I
I
K
P
V
L
P
P
E
---
L
-
L
T
-
D
-
E
T
K
Y
L
I
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
C
R
Y
V
A
K
N
I
V
A
A
G
L
A
T
Q
C
Q
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
S
I
D
T
F
G
T
G
K
--
I
S
E
E
K
L
I
A
L
V
C
E
H
F
D
L
R
P
K
G
I
V
Q
M
L
D
L
L
R
P
I
Y
G
K
S
A
A
Y
G
H
F
G
R
E
E
P
E
F
T
W
E
R
T
D
K
A
A
S
L
K
A
A
---
39
PsiBlast_CBE
71.18
61%
-10
- C4 -
-
5A1I
3
METK2_HUMAN
A:
[19-388]
-----
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
H
--
L
D
R
N
E
E
D
-------
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
---
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
---
R
---
G
A
V
L
-
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
D
-
E
-----
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
--------------
40
PsiBlast_CBE
70.88
61%
-14
* C4 *
-
5A1G
5
METK2_HUMAN
A:
[19-388]
-----
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
H
--
L
D
R
N
E
E
D
-------
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
---
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
---
R
---
G
A
V
L
-
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
D
-
E
-----
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
--------------
41
PsiBlast_CBE
69.06
61%
-11
- C4 -
-
5A19
7
METK2_HUMAN
A:
[19-388]
-----
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
-------------
E
E
D
-------
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
---
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
---
R
---
G
A
V
L
-
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
D
-
E
-----
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
--------------
74
HHSearch
68.89
63%
-0
- C4 -
-
3S82
3
METK_MYCA1
B:
[6-407]
S
E
K
G
R
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
--------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
---
N
G
---
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
-
E
D
-------
D
V
---
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
E
N
T
-----
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
AHD
T
-
L
D
T
S
-
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
--
34
PsiBlast_CBE
68.58
60%
-13
- C4 -
-
1O9T
1
METK1_RAT
A:
[20-394]
-----
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------
E
D
-------
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
---
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
---
N
---
G
A
V
I
-
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
E
-
A
-----
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
V
P
K
K
L
---------
17
PsiBlast_PDB
68.40
60%
-14
- C4 -
-
1QM4
1
METK1_RAT
A:
[20-394]
-----
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------
E
D
-------
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
---
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
---
N
---
G
A
V
I
-
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
E
-
A
-----
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
V
P
K
K
L
---------
73
HHSearch
68.37
63%
-2
- C4 -
-
3S82
3
METK_MYCA1
A:
[9-407]
---
G
R
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
--------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
---
N
G
---
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
-
E
D
-------
D
V
---
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
E
N
T
-----
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
AHD
T
-
L
D
T
S
-
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
--
18
PsiBlast_PDB
68.33
60%
-15
- C4 -
-
1O90
1
METK1_RAT
A:
[20-394]
-----
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------
E
D
-------
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
---
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
---
N
---
G
A
V
I
-
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
E
-
A
-----
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
V
P
K
K
L
---------
77
HHSearch
68.28
53%
-17
- C4 -
-
4ODJ
1
?
A:
[29-413]
--
E
Q
F
L
F
S
S
E
S
V
C
S
G
H
P
D
K
L
C
D
Q
I
S
D
A
I
L
D
A
C
L
E
Q
D
P
E
S
F
V
A
C
E
T
C
T
K
T
G
F
I
M
V
F
G
E
I
T
T
K
A
---
N
V
N
Y
E
R
V
V
R
E
T
V
K
E
I
G
Y
D
S
E
E
K
G
L
D
Y
K
T
M
D
V
I
I
K
L
E
Q
Q
S
N
Q
I
A
G
C
V
H
V
D
K
---------
N
V
E
D
I
G
A
G
D
Q
G
M
M
F
G
Y
A
T
N
E
T
K
E
L
M
P
L
T
H
V
L
A
T
S
I
T
R
E
L
D
Y
I
R
M
---
K
G
VSS
R
V
G
W
L
R
P
D
G
K
A
Q
V
T
V
E
Y
-
N
C
---
K
HG
V
L
I
---
P
K
R
I
H
T
I
L
V
S
V
Q
H
D
E
N
I
E
N
E
-
E
-----
I
R
E
F
V
L
E
N
V
I
K
K
V
C
P
S
D
---
L
-
M
D
-
K
-
E
T
R
I
L
I
N
P
S
G
R
F
T
I
G
G
P
A
A
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
A
T
K
V
D
R
S
G
A
Y
M
A
R
L
V
A
K
S
I
V
F
S
G
L
C
S
R
C
L
V
Q
V
S
Y
G
I
G
I
A
R
P
L
S
L
Y
I
N
T
F
G
T
A
K
DG
Y
N
D
T
K
L
L
E
I
V
N
K
V
F
D
F
R
P
G
I
L
I
K
Q
L
N
L
K
S
P
I
F
K
K
T
S
S
G
G
H
F
G
R
S
E
K
E
F
L
W
E
K
P
I
I
L
---------
19
PsiBlast_PDB
68.20
60%
-14
- C4 -
-
1O92
2
METK1_RAT
A:
[20-394]
-----
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------
E
D
-------
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
---
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
---
N
---
G
A
V
I
-
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
E
-
A
-----
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
V
P
K
K
L
---------
20
PsiBlast_PDB
68.00
60%
-14
- C4 -
-
1O93
2
METK1_RAT
A:
[20-394]
-----
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------
E
D
-------
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
---
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
---
N
---
G
A
V
I
-
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
E
-
A
-----
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
V
P
K
K
L
---------
61
PsiBlast_CBE
67.72
51%
-16
- C4 -
-
4ODJ
1
?
A:
[29-408]
--
E
Q
F
L
F
S
S
E
S
V
C
S
G
H
P
D
K
L
C
D
Q
I
S
D
A
I
L
D
A
C
L
E
Q
D
P
E
S
F
V
A
C
E
T
C
T
K
T
G
F
I
M
V
F
G
E
I
T
T
K
A
---
N
V
N
Y
E
R
V
V
R
E
T
V
K
E
I
G
Y
D
S
E
E
K
G
L
D
Y
K
T
M
D
V
I
I
K
L
E
Q
Q
S
N
Q
I
A
G
C
V
H
V
D
K
N
V
E
D
---------
I
G
A
G
D
Q
G
M
M
F
G
Y
A
T
N
E
T
K
E
L
M
P
L
T
H
V
L
A
T
S
I
T
R
E
L
D
Y
I
R
M
KGV
S
S
---
R
V
G
W
L
R
P
D
G
K
A
Q
V
T
V
E
Y
-
N
C
---
K
---
H
G
V
L
I
P
K
R
I
H
T
I
L
V
S
V
Q
H
D
E
N
I
E
N
E
-
E
-----
I
R
E
F
V
L
E
N
V
I
K
K
V
C
P
S
D
---
L
-
M
D
-
K
-
E
T
R
I
L
I
N
P
S
G
R
F
T
I
G
G
P
A
A
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
A
T
K
V
D
R
S
G
A
Y
M
A
R
L
V
A
K
S
I
V
F
S
G
L
C
S
R
C
L
V
Q
V
S
Y
G
I
G
I
A
R
P
L
S
L
Y
I
N
T
F
G
T
A
K
DG
Y
N
D
T
K
L
L
E
I
V
N
K
V
F
D
F
R
P
G
I
L
I
K
Q
L
N
L
K
S
P
I
F
K
K
T
S
S
G
G
H
F
G
R
S
E
K
E
F
L
W
E
--------------
29
PsiBlast_CBE
67.26
61%
-2
- C4 -
-
3S82
3
METK_MYCA1
B:
[11-407]
-----
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
--------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
---
N
G
---
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
-
E
D
---
D
----
V
---
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
E
-
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
A
H
D
T
---
L
-
D
T
-
S
-
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
--
14
PsiBlast_PDB
66.95
61%
-3
- C4 -
-
3S82
3
METK_MYCA1
A:
[11-407]
-----
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
--------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
---
N
G
---
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
-
E
D
---
D
----
V
---
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
E
-
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
A
H
D
T
---
L
-
D
T
-
S
-
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
--
66
Fugue
27.93
54%
18
- C4 -
-
1QM4
1
METK1_RAT
A:
[129-251]
------------------------------------------------------------------------------------------------------------------------------
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
---
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
-
V
Q
D
N
G
A
---
V
I
---
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
E
-
A
-----
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
------------------------------------------------------------------------------------------------------------------------------------------------------------