@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XWN8: (2017-12-31 )
MVVGDFAVELDTVVIGAGPGGYVAAIRAAEMGQKVAIIEREYIGGVCLNVGCIPSKALIAAGHHYQESLDSEMFGVTSENVKLDFAKTQEWKENKVVHTLTSGVGFLLKKHKVETIEGEAFFVDDHTLRVIHPDSAQTYSFNNAIIATGSRPIEIPGFKFGGRVLDSTGGLALKEVPKKFVIIGGGVIGAELGGAYANLGAEVTILEGSPQILPTYEKDLVKLVEDDFKKKGVTVVTNAMAKEAVDNGDSVTVKYAVDGKEESVTADYVMVTVGRRPNTDDMGLEQAGVEVGERGLITVDKQGRTNVPNIYAIGDIVPGAALAHKASYEAKIAAEAISGKKVAVDYKAMPAVAFTDPELASVGMTIKEAKDAGIEAKAYKFPFSGNGRALSLGKTEGFIRLVTTIEDNVLIGAQIGGVGASDMVSELALAIESGMNAEDIALTIHPHPSLGEIVMDASELALGLPIHI
Atome Classification :
(36 SA)
.........10........20........30........-40------..-------..--------.....50........60.......-.-70-..---.....-.80........90........100.......110.......120...---------....130----...-----------.-...-.-----.140.......150.......160-.-.------..-.-....170.-..-....180.......190......-.200.......210....-...220-...--....-230.......--.240.......250...-.--.--.-.260-.---........270.......280.......290.......300.......310.....-.-.320........330.......340.......350----.........360.......370.......380.......390.....----..400.......410...-....420.......430.......440.--......450.......460......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVV
G
D
F
A
V
E
L
D
T
V
V
I
GAGPG
G
Y
V
A
A
I
R
A
A
EMG
Q
K
V
A
I
I
E
-R-------EY-------I
G
--------
G
V
C
L
NVGCIP
S
K
A
L
I
AAG
H
H
Y
Q
E
S
-
L
-
D
S
-
E
M
---FGVTS-E
N
V
K
L
D
FAKT
Q
E
WKEN
K
V
V
H
T
L
T
S
G
V
G
F
L
L
K
KH
K
V
E
TIEG
E
A
F
F
VDD---------
H
T
L
R
V
------IHP-----------D-SA
Q
-
T
-----YSFN
N
A
I
I
ATGSR
P
I
EIPGFKF---G-
G
------
R
V
-L-DSTGGL
A
L
-
K
E-VPK
K
F
V
I
I
GGG
V
I
G
A
ELGG
A
Y
AN-LG
A
E
V
T
I
LEGSP
Q
I
LP
T
Y
-
E
K
D
L
V
K
-
L
V
E
--
D
D
F
K-KK-
G
V
T
V
V
T
N
--
A
M
A
K
E
AVDNGD
S
V
T
V
K
Y
-
A
--V--D-GK---E---ESVT
A
D
Y
V
M
V
T
VGRRPNTDDM
G
L
E
Q
A
G
V
E
VGER
G
L
I
T
VDKQGRTNVP
N
I
Y
A
IGDIV-P-
G
A
-
A
L
A
HKASYE
A
K
I
A
A
EAISG
K
K
V
A
V
D
YKAM
P
------
A
V
AFTDP
E
L
A
S
VG
M
T
I
K
EAKDAGIEA
K
A
Y
KFPFSGN
G
R
A
L
SLGKTE
G
----
F
I
R
L
V
T
TIED
N
V
L
I
G
A
QI-GGV
G
A
S
D
M
V
S
E
L
A
L
A
I
ESGM
N
A
E
D
I
A
L
T
--IHPHPS
L
G
E
I
V
M
D
A
S
E
LALGLPIHI
1
PsiBlast_PDB
98.07
63%
-120
- C3 -
-
1EBD
2
DLDH1_GEOSE
A:
[1-455]
------
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
-
K
-------
G
N
-------
L
G
--------
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
E
Q
A
-
K
-
H
S
-
E
E
---
M
G
I
K
A
-
E
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
-
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
---------
N
T
V
R
V
------
V
N
G
-----------
D
-
S
A
Q
-
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
F
---
S
-
N
------
R
I
-
L
-
D
S
T
G
A
L
N
L
-
G
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
-
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
-
I
I
K
--
K
R
L
K
-
K
K
-
G
V
E
V
V
T
N
--
A
L
A
K
G
A
E
E
R
E
D
G
V
T
V
T
Y
-
E
--
A
--
N
-
G
E
---
T
---
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
-
P
-
G
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
S
A
V
D
Y
V
A
I
P
------
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
-
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
--
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
E
V
A
L
------
21
PsiBlast_CBE
96.91
63%
-118
- C3 -
-
1EBD
2
DLDH1_GEOSE
B:
[1-455]
------
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
-
K
-------
G
N
-------
L
G
--------
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
E
Q
A
-
K
-
H
S
-
E
E
---
M
G
I
K
A
-
E
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
-
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
---------
N
T
V
R
V
------
V
N
G
-----------
D
-
S
A
Q
-
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
F
---
S
-
N
------
R
I
-
L
-
D
S
T
G
A
L
N
L
-
G
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
-
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
-
I
I
K
--
K
R
L
K
-
K
K
-
G
V
E
V
V
T
N
--
A
L
A
K
G
A
E
E
R
E
D
G
V
T
V
T
Y
-
E
--
A
--
N
-
G
E
---
T
---
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
-
P
-
G
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
S
A
V
D
Y
V
A
I
P
------
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
-
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
--
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
E
V
A
L
------
128
HHSearch
74.80
45%
-22
- C3 -
-
2EQ6
2
?
B:
[4-461]
------
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
--
K
P
E
L
D
L
K
K
L
G
G
W
R
D
-
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
--------
G
--------------
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
E
G
-
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
--
T
K
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
-
E
--
P
AE
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
-
Q
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
8
PsiBlast_PDB
74.26
42%
-15
- C3 -
-
2YQU
2
?
A:
[3-455]
----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
-
K
-------
E
K
A------
L
G
--------
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
A
---
K
K
-
G
L
---
L
G
A
K
V
-
K
G
V
E
L
D
L
P
A
L
M
A
H
K
-
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
---------
R
--
K
V
------
L
V
E
-----------
E
-
T
G
E
-
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
V
---
D
Y
E
------
R
V
-
V
-
T
S
T
E
A
L
S
F
-
P
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
-
A
A
E
--
R
V
F
K
-
K
Q
-
G
L
T
I
R
T
G
--
V
R
V
T
A
V
V
P
E
A
K
G
A
R
V
E
-----
L
--
E
-
G
G
---
E
----
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
-
R
-
G
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
V
D
Y
Q
A
I
P
------
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
-
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
--
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
127
HHSearch
74.21
45%
-23
- C3 -
-
2EQ8
2
?
A:
[4-461]
------
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
--
K
P
E
L
D
L
K
K
L
G
G
W
R
D
-
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
--------
G
--------------
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
E
G
-
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
--
T
K
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
-
E
--
P
AE
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
-
Q
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
25
PsiBlast_CBE
74.14
45%
-22
- C3 -
-
2EQ9
2
?
G:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
-
K
P
-
E
L
D
L
K
K
L
G
G
W
R
-
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------
G
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
-
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
TK
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
E
P
-
A
--
E
--
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
28
PsiBlast_CBE
73.91
45%
-21
- C3 -
-
2EQ9
2
?
B:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
-
K
P
-
E
L
D
L
K
K
L
G
G
W
R
-
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------
G
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
-
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
TK
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
E
P
-
A
--
E
--
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
31
PsiBlast_CBE
73.66
45%
-22
- C3 -
-
2EQ8
2
?
B:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
-
K
P
-
E
L
D
L
K
K
L
G
G
W
R
-
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------
G
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
-
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
TK
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
E
P
-
A
--
E
--
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
29
PsiBlast_CBE
73.35
45%
-20
- C3 -
-
2EQ8
2
?
E:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
-
K
P
-
E
L
D
L
K
K
L
G
G
W
R
-
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------
G
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
-
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
TK
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
E
P
-
A
--
E
--
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
32
PsiBlast_CBE
73.11
45%
-19
- C3 -
-
2EQ6
2
?
B:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
-
K
P
-
E
L
D
L
K
K
L
G
G
W
R
-
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------
G
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
-
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
TK
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
E
P
-
A
--
E
--
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
39
PsiBlast_CBE
72.93
42%
-13
- C3 -
-
2YQU
2
?
B:
[3-455]
----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
-
K
-------
E
K
A------
L
G
--------
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
A
---
K
K
-
G
L
---
L
G
A
K
V
-
K
G
V
E
L
D
L
P
A
L
M
A
H
K
-
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
---------
R
--
K
V
------
L
V
E
-----------
E
-
T
G
E
-
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
V
---
D
Y
E
------
R
V
-
V
-
T
S
T
E
A
L
S
F
-
P
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
-
A
A
E
--
R
V
F
K
-
K
Q
-
G
L
T
I
R
T
G
--
V
R
V
T
A
V
V
P
E
A
K
G
A
R
V
E
-----
L
--
E
-
G
G
---
E
----
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
-
R
-
G
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
V
D
Y
Q
A
I
P
------
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
-
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
--
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
22
PsiBlast_CBE
72.91
45%
-21
- C3 -
-
2EQ9
2
?
K:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
-
K
P
-
E
L
D
L
K
K
L
G
G
W
R
-
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------
G
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
-
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
TK
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
E
P
-
A
--
E
--
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
7
PsiBlast_PDB
72.80
42%
-14
- C3 -
-
2EQ7
3
?
A:
[3-452]
----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
-
K
-------
E
K
A------
L
G
--------
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
A
---
K
K
-
G
L
---
L
G
A
K
V
-
K
G
V
E
L
D
L
P
A
L
M
A
H
K
-
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
---------
R
--
K
V
------
L
V
E
-----------
E
-
T
G
E
-
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
V
---
D
Y
E
------
R
V
-
V
-
T
S
T
E
A
L
S
F
-
P
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
-
A
A
E
--
R
V
F
K
-
K
Q
-
G
L
T
I
R
T
G
--
V
R
V
T
A
V
V
P
E
A
K
G
A
R
V
E
-----
L
--
E
-
G
G
---
E
----
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
-
R
-
G
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
V
D
Y
Q
A
I
P
------
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
-
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
--
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
---
24
PsiBlast_CBE
72.79
45%
-21
- C3 -
-
2EQ9
2
?
H:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
-
K
P
-
E
L
D
L
K
K
L
G
G
W
R
-
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------
G
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
-
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
TK
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
E
P
-
A
--
E
--
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
3
PsiBlast_PDB
72.76
45%
-19
- C3 -
-
2EQ8
2
?
A:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
-
K
P
-
E
L
D
L
K
K
L
G
G
W
R
-
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------
G
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
-
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
E
P
-
A
--
E
--
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
4
PsiBlast_PDB
72.70
45%
-23
- C3 -
-
2EQ9
2
?
A:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
-
K
P
-
E
L
D
L
K
K
L
G
G
W
R
-
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------
G
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
-
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
E
P
-
A
--
E
--
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
30
PsiBlast_CBE
72.62
45%
-22
- C3 -
-
2EQ8
2
?
D:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
-
K
P
-
E
L
D
L
K
K
L
G
G
W
R
-
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------
G
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
-
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
TK
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
E
P
-
A
--
E
--
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
2
PsiBlast_PDB
72.55
45%
-19
- C3 -
-
2EQ6
2
?
A:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
-
K
P
-
E
L
D
L
K
K
L
G
G
W
R
-
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------
G
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
-
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
E
P
-
A
--
E
--
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
26
PsiBlast_CBE
72.34
45%
-20
- C3 -
-
2EQ9
2
?
E:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
-
A
-------
G
E
-------
V
G
--------
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
-
E
G
---
F
G
L
K
A
-
K
P
-
E
L
D
L
K
K
L
G
G
W
R
-
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------
G
G
E
-
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
---
G
-
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
-
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
-
L
L
R
--
R
A
L
E
-
K
E
-
G
I
R
V
R
T
K
TK
A
V
G
Y
E
K
K
K
D
G
L
H
V
R
L
E
P
-
A
--
E
--
G
-
G
E
---
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
A
F
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
-
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
40
PsiBlast_CBE
72.18
42%
-14
- C3 -
-
2EQ7
3
?
B:
[3-452]
----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
-
K
-------
E
K
A------
L
G
--------
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
A
---
K
K
-
G
L
---
L
G
A
K
V
-
K
G
V
E
L
D
L
P
A
L
M
A
H
K
-
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
---------
R
--
K
V
------
L
V
E
-----------
E
-
T
G
E
-
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
V
---
D
Y
E
------
R
V
-
V
-
T
S
T
E
A
L
S
F
-
P
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
-
A
A
E
--
R
V
F
K
-
K
Q
-
G
L
T
I
R
T
G
--
V
R
V
T
A
V
V
P
E
A
K
G
A
R
V
E
-----
L
--
E
-
G
G
---
E
----
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
-
R
-
G
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
H
V
D
Y
Q
A
I
P
------
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
-
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
--
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
---
131
HHSearch
70.58
39%
10
- C3 -
-
3URH
3
?
B:
[26-490]
---------
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
R
-------
S
T
-------
Y
G
--------
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
H
Q
A
-
Q
H
G
L
-
E
A
---
L
G
V
E
V
-
A
N
P
K
L
N
L
Q
K
M
M
A
H
K
D
-
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
---------
G
K
V
S
V
------
T
N
E
-----------
K
G
E
E
Q
-
V
-----
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
V
AFD
E
-
K
------
T
I
-
V
-
S
S
T
G
A
L
A
L
-
E
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
-
D
G
E
V
A
K
-
Q
L
Q
--
R
M
L
T
-
K
Q
-
G
I
D
F
K
L
G
--
A
K
V
T
G
A
V
K
S
G
D
G
A
K
V
T
F
-
E
PV
K
--
G
-
G
E
---
A
---
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
-
R
-
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
Q
A
G
H
V
N
Y
D
V
I
P
------
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
----
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
-
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
--
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
K
P
I
H
-
130
HHSearch
69.68
39%
12
- C3 -
-
3URH
2
?
A:
[26-486]
---------
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
R
-------
S
T
-------
Y
G
--------
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
H
Q
A
-
Q
H
G
L
-
E
A
---
L
G
V
E
V
-
A
N
P
K
L
N
L
Q
K
M
M
A
H
K
D
-
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
---------
G
K
V
S
V
------
T
N
E
-----------
K
G
E
E
Q
-
V
-----
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
V
A
F
D
E
-
K
------
T
I
-
V
-
S
S
T
G
A
L
A
L
-
E
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
-
D
G
E
V
A
K
-
Q
L
Q
--
R
M
L
T
-
K
Q
-
G
I
D
F
K
L
G
--
A
K
V
T
G
A
V
K
S
G
D
G
A
K
V
T
F
-
E
PV
K
--
G
-
G
E
---
A
---
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
-
R
-
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
Q
A
G
H
V
N
Y
D
V
I
P
------
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
----
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
-
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
--
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
-----
84
PsiBlast_CBE
69.65
38%
1
- C3 -
-
3LAD
2
DLDH_AZOVI
B:
[3-471]
--------
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
-
K
YKGKEGK
T
A
-------
L
G
--------
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
H
E
A
-
H
-
E
S
F
K
L
---
H
G
I
S
T
-
G
E
V
A
I
D
V
-
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
L
L
A
G
---------
K
K
V
E
V
------
T
A
A
-----------
D
G
S
S
Q
-
V
-----
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
P
A
P
V
---
D
-
Q
------
D
V
-
I
V
D
S
T
G
A
L
D
F
-
Q
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
-
D
E
Q
V
A
K
-
E
A
Q
--
K
I
L
T
-
K
Q
-
G
L
K
I
L
L
G
--
A
R
V
T
G
T
E
V
K
N
K
Q
V
T
V
K
F
-
V
--
D
--
A
-
E
G
---
E
---
K
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
-
R
-
G
A
-
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
A
Q
M
N
Y
D
L
I
P
------
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
----
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
-
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
--
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
132
HHSearch
69.46
42%
8
* C3 *
-
2QAE
2
DLDH_TRYCR
A:
[2-467]
--------
P
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
R
-------
G
A
-------
L
G
--------
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
H
D
A
-
H
A
N
F
-
A
R
---
Y
G
L
M
G
G
E
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
-
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
---------
H
S
I
R
V
------
N
G
L
-----------
D
G
K
Q
E
-
M
-----
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
-
F
L
P
F--
D
E
K
------
V
V
-
L
-
S
S
T
G
A
L
A
L
-
P
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
-
D
E
D
V
T
N
-
A
L
V
--
G
A
L
A
K
N
E
-
K
M
K
F
M
T
S
--
T
K
V
V
G
G
T
N
N
G
D
S
V
S
L
E
V
-
E
G-
K
---------
R
---
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
-
D
K
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
G
H
V
N
Y
G
V
I
P
------
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
----
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
-
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
--
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
-
19
PsiBlast_PDB
69.03
39%
2
- C3 -
-
5TR3
3
?
A:
[7-475]
--------
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
L
K
T
A
C
I
E
-
K
-------
Y
T
DAEGKLA
L
G
--------
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
W
K
Y
K
E
A
-
K
-
E
S
F
N
V
---
H
G
I
S
T
-
G
E
V
K
M
D
V
A
A
M
V
G
R
K
A
G
-
I
V
K
N
L
T
G
G
V
A
T
L
F
K
A
N
G
V
T
S
I
Q
G
H
G
K
L
L
A
G
---------
K
K
V
E
V
------
T
K
A
-----------
D
G
T
T
E
-
V
-----
I
E
A
E
N
V
I
L
A
S
G
S
R
P
I
D
I
P
P
A
P
V
---
D
-
Q
------
N
V
-
I
V
D
S
T
G
A
L
E
F
-
Q
A
-
V
P
K
R
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
L
D
T
F
L
M
A
A
-
D
T
A
V
S
K
-
E
A
Q
--
K
T
L
T
-
K
Q
-
G
L
D
I
K
L
G
--
A
R
V
T
G
S
K
V
N
G
N
E
V
E
V
T
Y
-
T
--
N
--
A
-
E
G
---
E
---
Q
K
I
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
S
D
S
G
V
T
I
D
E
R
G
Y
I
F
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
-
R
-
G
M
-
M
L
A
H
K
A
S
E
E
G
I
M
V
V
E
R
I
K
G
H
K
A
Q
M
N
Y
D
L
I
P
------
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
A
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
G
G
----
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
-
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
--
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
G
A
I
H
V
18
PsiBlast_PDB
68.93
38%
3
- C3 -
-
3LAD
2
DLDH_AZOVI
A:
[3-471]
--------
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
-
K
YKGKEGK
T
A
-------
L
G
--------
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
H
E
A
-
H
-
E
S
F
K
L
---
H
G
I
S
T
-
G
E
V
A
I
D
V
-
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
L
L
A
G
---------
K
K
V
E
V
------
T
A
A
-----------
D
G
S
S
Q
-
V
-----
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
P
A
P
V
---
D
-
Q
------
D
V
-
I
V
D
S
T
G
A
L
D
F
-
Q
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
-
D
E
Q
V
A
K
-
E
A
Q
--
K
I
L
T
-
K
Q
-
G
L
K
I
L
L
G
--
A
R
V
T
G
T
E
V
K
N
K
Q
V
T
V
K
F
-
V
--
D
--
A
-
E
G
---
E
---
K
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
-
R
-
G
A
-
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
A
Q
M
N
Y
D
L
I
P
------
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
----
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
-
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
--
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
136
HHSearch
68.49
43%
-4
- C3 -
-
5U25
2
?
A:
[122-592]
-----
A
D
A
E
Y
D
V
V
V
L
G
G
G
P
G
G
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
Y
-------
K
T
-------
L
G
--------
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
A
V
I
D
E
V
-
R
-
H
L
-
A
A
---
N
G
I
K
Y
-
P
E
P
E
L
D
I
D
M
L
R
A
Y
K
D
-
G
V
V
S
R
L
T
G
G
L
A
G
M
A
K
S
R
K
V
D
V
I
Q
G
D
G
Q
F
L
D
P
---------
H
H
L
E
V
------
S
L
T
A
G
DAYE
Q
A
A
P
T
G
-
E
K
K
-
I
-----
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
K
L
P
-
F
I
P
E
--
D
-
P
------
R
I
-
I
-
D
S
S
G
A
L
A
L
-
K
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
-
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
G
A
-
D
R
D
L
V
K
-
V
W
Q
--
K
Q
N
E
-
Y
R
-
F
D
N
I
M
V
N
--
T
K
T
V
A
V
E
P
K
E
D
G
V
Y
V
T
F
-
E
--
G
--
A
N
A
P
---
K
---
E
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
-
G
-
Q
P
-
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
A
Y
F
D
A
R
V
I
P
------
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
G
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
N
G
----
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
-
V
G
P
N
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
--
I
H
P
H
P
T
L
G
E
S
I
G
M
A
A
E
V
A
L
G
V
----
85
PsiBlast_CBE
68.36
39%
2
- C3 -
-
5TR3
4
?
B:
[7-475]
--------
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
L
K
T
A
C
I
E
-
K
-------
Y
T
DAEGKLA
L
G
--------
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
W
K
Y
K
E
A
-
K
-
E
S
F
N
V
---
H
G
I
S
T
-
G
E
V
K
M
D
V
A
A
M
V
G
R
K
A
G
-
I
V
K
N
L
T
G
G
V
A
T
L
F
K
A
N
G
V
T
S
I
Q
G
H
G
K
L
L
A
G
---------
K
K
V
E
V
------
T
K
A
-----------
D
G
T
T
E
-
V
-----
I
E
A
E
N
V
I
L
A
S
G
S
R
P
I
D
I
P
P
A
P
V
---
D
-
Q
------
N
V
-
I
V
D
S
T
G
A
L
E
F
-
Q
A
-
V
P
K
R
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
L
D
T
F
L
M
A
A
-
D
T
A
V
S
K
-
E
A
Q
--
K
T
L
T
-
K
Q
-
G
L
D
I
K
L
G
--
A
R
V
T
G
S
K
V
N
G
N
E
V
E
V
T
Y
-
T
--
N
--
A
-
E
G
---
E
---
Q
K
I
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
S
D
S
G
V
T
I
D
E
R
G
Y
I
F
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
-
R
-
G
M
-
M
L
A
H
K
A
S
E
E
G
I
M
V
V
E
R
I
K
G
H
K
A
Q
M
N
Y
D
L
I
P
------
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
A
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
G
G
----
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
-
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
--
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
G
A
I
H
V
116
Fugue
67.03
56%
1
- C3 -
-
1EBD
2
DLDH1_GEOSE
A:
[1-455]
------
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
-
K
-------
G
N
-------
L
G
--------
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
E
Q
A
-
K
-
H
--
S
E
EMG
I
K
A
E
---
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
K
-
V
E
I
V
K
-
G
E
A
Y
F
V
-DAN
T
V
R
V
V
N
-------------
G
-----------
D
-
S
A
Q
-
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
F
---
S
--NRILD
S
T
G
-
A
-
L
N
L
G
------
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
-
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
-F
E
K
Q
M
A
A
-
I
I
K
--
K
R
L
K
-
K
K
-
G
V
E
V
V
T
N
--
A
L
A
K
G
A
E
E
R
E
-
D
G
V
T
V
T
-
Y
--
E
--
A
-
N
-G
E
T
K
---
T
I
D
-
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
-
P
-
G
-P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
-----
H
P
S
A
V
D
YV
A
I
P
A
V
V
F
S
D
-
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
----
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
DTD
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
-
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
--
L
G
E
I
A
M
E
A
A
E
V
A
L
------
5
PsiBlast_PDB
66.35
42%
20
- C3 -
-
4JDR
4
DLDH_ECOLI
A:
[5-458]
-------
I
K
T
Q
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
-
R
Y------
N
T
-------
L
G
--------
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
V
I
E
E
A
-
K
-
A
L
-
A
E
---
H
G
I
V
F
-
G
E
P
K
T
D
I
D
K
I
R
T
W
K
E
-
K
V
I
N
Q
L
T
G
G
L
A
G
M
A
K
G
R
K
V
K
V
V
N
G
L
G
K
F
T
G
A
---------
N
T
L
E
V
------
E
G
E
-----------
N
-
G
K
T
-
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
F
I
P
H
E--
D
-
P
------
R
I
-
W
-
D
S
T
D
A
L
E
L
-
K
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
-
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
-
D
K
D
I
V
K
-
V
F
T
--
K
R
I
S
-
K
K
F
N
L
M
L
E
T
K
--
V
T
A
V
E
A
K
E
D
G
I
Y
V
T
M
---------
E
-
G
K
---
K
APA
E
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
-
G
-
Q
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
H
Y
F
D
P
K
V
I
P
------
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
----
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
-
V
G
T
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
--
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
E
V
--------
9
PsiBlast_PDB
66.16
39%
18
- C3 -
-
1LPF
2
DLDH_PSEFL
A:
[3-471]
--------
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
-
K
--------
Y
-------
I
G
KEGKVALG
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
-
K
-
E
A
F
K
V
---
H
G
I
E
A
-
K
G
V
T
I
D
V
P
A
M
V
A
R
K
A
N
-
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
---------
K
Q
V
E
V
------
T
G
L
-----------
D
G
K
T
Q
-
V
-----
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
L
---
S
-
D
------
D
I
-
I
V
D
S
T
G
A
L
E
F
-
Q
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
-
D
E
Q
I
A
K
-
E
A
L
--
K
V
L
T
-
K
Q
-
G
L
N
I
R
L
G
--
A
R
V
T
A
S
E
V
K
K
K
Q
V
T
V
T
F
-
T
--
D
--
A
-
N
G
---
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
-
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
N
Y
D
L
I
P
------
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
----
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
-
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
--
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
38
PsiBlast_CBE
66.07
42%
21
- C3 -
-
4JDR
3
DLDH_ECOLI
B:
[5-458]
-------
I
K
T
Q
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
-
R
Y------
N
T
-------
L
G
--------
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
V
I
E
E
A
-
K
-
A
L
-
A
E
---
H
G
I
V
F
-
G
E
P
K
T
D
I
D
K
I
R
T
W
K
E
-
K
V
I
N
Q
L
T
G
G
L
A
G
M
A
K
G
R
K
V
K
V
V
N
G
L
G
K
F
T
G
A
---------
N
T
L
E
V
------
E
G
E
-----------
N
-
G
K
T
-
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
F
I
P
H
E--
D
-
P
------
R
I
-
W
-
D
S
T
D
A
L
E
L
-
K
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
-
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
-
D
K
D
I
V
K
-
V
F
T
--
K
R
I
S
-
K
K
F
N
L
M
L
E
T
K
--
V
T
A
V
E
A
K
E
D
G
I
Y
V
T
M
---------
E
-
G
K
---
K
APA
E
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
-
G
-
Q
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
H
Y
F
D
P
K
V
I
P
------
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
----
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
-
V
G
T
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
--
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
E
V
--------
41
PsiBlast_CBE
65.46
39%
17
- C3 -
-
1LPF
2
DLDH_PSEFL
B:
[3-471]
--------
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
-
K
--------
Y
-------
I
G
KEGKVALG
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
-
K
-
E
A
F
K
V
---
H
G
I
E
A
-
K
G
V
T
I
D
V
P
A
M
V
A
R
K
A
N
-
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
---------
K
Q
V
E
V
------
T
G
L
-----------
D
G
K
T
Q
-
V
-----
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
L
---
S
-
D
------
D
I
-
I
V
D
S
T
G
A
L
E
F
-
Q
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
-
D
E
Q
I
A
K
-
E
A
L
--
K
V
L
T
-
K
Q
-
G
L
N
I
R
L
G
--
A
R
V
T
A
S
E
V
K
K
K
Q
V
T
V
T
F
-
T
--
D
--
A
-
N
G
---
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
-
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
Q
M
N
Y
D
L
I
P
------
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
----
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
-
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
--
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
102
PsiBlast_CBE
62.52
42%
3
- C3 -
-
5U25
2
?
A:
[138-592]
---------------------
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
-
R
Y------
K
T
-------
L
G
--------
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
A
V
I
D
E
V
-
R
-
H
L
-
A
A
---
N
G
I
K
Y
-
P
E
P
E
L
D
I
D
M
L
R
A
Y
K
D
G
-
V
V
S
R
L
T
G
G
L
A
G
M
A
K
S
R
K
V
D
V
I
Q
G
D
G
Q
F
L
D
P
---------
H
H
L
E
V
S
L
T
A
G
D
A
Y
E
-----------
Q
-
A
A
P
-
T
G
E
K
K
I
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
K
L
P
F
I
P
E
---
D
-
P
------
R
I
-
I
-
D
S
S
G
A
L
A
L
-
K
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
-
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
G
A
-
D
R
D
L
V
K
-
V
W
Q
K
Q
N
E
Y
R
-
F
D
-
N
I
M
V
N
T
K
--
T
V
A
V
E
P
K
E
D
G
V
Y
V
T
F
E
G
-
A
-----
N
-
A
P
---
K
---
E
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
-
G
-
Q
P
-
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
A
Y
F
D
A
R
V
I
P
------
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
G
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
N
G
----
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
-
V
G
P
N
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
--
I
H
P
H
P
T
L
G
E
S
I
G
M
A
A
E
V
A
L
G
V
----
20
PsiBlast_PDB
61.20
41%
31
- C3 -
-
2QAE
2
DLDH_TRYCR
A:
[17-458]
-----------------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
R
-------
G
A
-------
L
G
--------
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
H
D
A
H
A
-
N
F
-
A
R
---
Y
G
L
M
G
G
E
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
-
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
---------
H
S
I
R
V
------
N
G
L
-----------
D
-
G
K
Q
E
M
-----
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
F
L
P
F
---
D
-
E
------
K
V
V
L
-
S
S
T
G
A
L
A
L
-
P
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
-
D
E
D
V
T
N
A
L
V
G
--
A
L
A
K
-
N
E
-
K
M
K
F
M
T
S
--
T
K
V
V
G
G
T
N
N
G
D
S
V
S
L
E
V
E
--------
G
K
---
R
---
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
-
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
G
H
V
N
Y
G
V
I
P
------
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
----
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
-
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
--
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
----------
86
PsiBlast_CBE
60.87
41%
32
- C3 -
-
2QAE
2
DLDH_TRYCR
B:
[17-458]
-----------------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
R
-------
G
A
-------
L
G
--------
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
H
D
A
H
A
-
N
F
-
A
R
---
Y
G
L
M
G
G
E
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
-
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
---------
H
S
I
R
V
------
N
G
L
-----------
D
-
G
K
Q
E
M
-----
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
F
L
P
F
---
D
-
E
------
K
V
V
L
-
S
S
T
G
A
L
A
L
-
P
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
-
D
E
D
V
T
N
A
L
V
G
--
A
L
A
K
-
N
E
-
K
M
K
F
M
T
S
--
T
K
V
V
G
G
T
N
N
G
D
S
V
S
L
E
V
E--------
G
K
---
R
---
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
-
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
G
H
V
N
Y
G
V
I
P
------
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
----
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
-
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
--
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
----------