@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XWY8: (2018-01-01 )
MKVKKLSLQTLRRFIPYLTAYAKDIWLAVILGIINGIATVVMTLQIGQSIDQMIGEGQVRFNRLFHLLILFGGIVLINVVSQWLIQVLSNRLAYLSVAKLRKDAFAHLNRLPLRYYDQNSHGNIVSRFTNDMDNISIAISAAFNQLFSGVAIIILSFIFMMRLSPLLTLVVLCSTPIIFLVSWIVARASQTNFDRQQRIIGDISGFVTERIGNQKIVKAFQQEEASQQQFELLNADLYEKGQRAQFSSSLTNPSSRFVDHLAYLSIGLVGGLLALKSGSSITVGVISSFTIYSSQFSKPFIELSGITTQLQTAFSGLERAFDLIDQPEEKPDLPDAYALEPKNIKGKVSFDHVSFSYDPKQRLIEDFNFTAYPGQTIAIVGKTGAGKSTLVNLLMRFYDTTKGTITVDDHDIRSIQRDTLRKSFGMVLQDTWLFDSTLRENLRFGNPEASDAEINDALKASYMYEFVERLPEKLDTKIGGQGLKISDGQRQLLTIARTMISNPPMLILDEATSSVDTLTEKKIQQAFLAMMEGKTSFVIAHRLSTIKNADQILVMDQGAIVEMGTHDELLQKDGYYRRLYQAQFTAQ
Atome Classification :
(29 SA)
.........10........20........30........40........50........-----60-------------....--------.....70.....---------...---80........90........100.......110.......120.......130.......140.......150.......160.......170......-.180...-....190.......200.......210.......220.......230.......240.......250........260.......---270.......280.......290.....----..300.......310.......320.......330.......---340..----.-....350.....-..-------360-.-..-.....370.......380.......390.......400.......410.......420.......430.......440...-..-.-.-450.......460.......470.......480.......490.......500..-.....510.......520.......530.......540.......550.......560.......570........580.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKVKKL
S
L
Q
T
L
R
R
F
I
P
Y
L
T
A
Y
A
K
D
I
W
L
A
V
I
L
G
I
I
N
G
I
A
T
V
V
M
T
L
Q
I
G
Q
S
I
D
Q
M
I
GEG
Q
V
-----
R
--------------
F
N
R
L
--------
F
H
L
L
I
L
F
G
G
I
V
L
---------
I
N
V
---
V
S
Q
W
L
I
Q
V
L
SN
R
L
A
Y
L
S
V
A
K
L
R
K
D
A
F
A
H
L
NRLP
L
R
Y
YDQNSH
G
N
I
V
S
R
F
TNDMD
N
I
S
I
A
I
S
A
A
F
N
Q
L
F
S
G
V
A
I
I
I
L
S
F
I
F
M
M
R
L
S
P
L
L
T
L
V
V
L
CS
T
P
I
I
-
F
L
V
S
W
I
V
-
A
RASQTN
F
D
R
Q
Q
R
I
I
G
D
I
S
G
F
V
T
E
RIG
N
Q
K
I
V
K
A
F
Q
Q
E
E
A
S
Q
Q
Q
F
E
L
L
N
A
D
L
Y
EKG
Q
R
A
Q
FSSSLT-N
P
S
S
R
F
V
D
H
L
A
Y
L
S
I
G
L
V
---
G
G
L
L
A
LKSGS
S
I
T
V
G
V
I
S
S
F
T
I
YSSQFS----K
P
F
I
E
LSG
I
T
T
Q
L
Q
T
A
F
S
G
L
E
R
A
F
D
L
IDQPEEKPDLPDAYAL---EPKNI----K-G
K
V
S
F
D
H
V
SFSY-
D
P
-------
K
Q
--
R
-
L
I
-
E
DFNFTAYPG
Q
T
I
A
I
V
GKTGA
G
K
S
T
L
V
N
L
L
M
R
F
YDTTK
G
T
I
T
VD
D
H
D
I
R
S
I
Q
R
D
T
L
R
K
S
F
G
M
V
L
Q
D
T
WL
F
D
S
T
L
R
E
NLRFG-NP-E-A-SD
A
E
I
N
D
A
L
K
A
S
Y
M
Y
E
F
V
E
R
L
P
E
K
L
D
T
KIGGQGLKISDG
Q
R
Q
L
L
T
I
A
R
T
MISNP
P
-
M
L
I
LDEATS
S
V
D
T
L
T
E
K
K
I
Q
Q
A
F
L
A
M
MEGK
T
S
F
V
I
A
H
R
L
S
TIKNA
D
Q
I
L
V
MDQG
A
I
V
EMG
T
H
D
E
L
L
-QKD
G
Y
Y
R
R
L
Y
Q
A
QFTAQ
1
PsiBlast_PDB
89.93
42%
-137
- C1 -
-
3QF4
1
Y288_THEMA
B:
[24-591]
---------
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
-------
R
--------------
F
D
L
L
--------
P
R
Y
M
L
I
L
G
T
I
Y
A
---------
L
T
S
---
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
-
V
L
I
T
Q
I
V
-
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
L
A
L
K
D
--
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
----
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
-
P
D
A
--
V
---
E
L
R
E
V
----
R
-
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-------
K
K
--
P
-
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
-
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
Y
---
99
HHSearch
89.10
42%
-135
- C1 -
-
3QF4
1
Y288_THEMA
B:
[22-590]
-------
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
---------------------
F
D
L
L
--------
P
R
Y
M
L
I
L
G
T
I
Y
A
---------
L
T
S
---
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
-
V
L
I
T
Q
I
V
-
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
L
A
L
K
D
--
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
----
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
---
V
---
E
L
R
E
V
----
R
-
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-------
K
K
--
P
-
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
-
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
----
2
PsiBlast_PDB
88.99
42%
-134
- C1 -
-
4Q4A
1
Y288_THEMA
B:
[24-591]
---------
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
-------
R
--------------
F
D
L
L
--------
P
R
Y
M
L
I
L
G
T
I
Y
A
---------
L
T
S
---
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
-
V
L
I
T
Q
I
V
-
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
L
A
L
K
D
--
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
----
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
-
P
D
A
--
V
---
E
L
R
E
V
----
R
-
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-------
K
K
--
P
-
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
-
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
Y
---
4
PsiBlast_PDB
87.30
41%
-133
- C1 -
-
4Q4J
-
Y288_THEMA
B:
[24-591]
---------
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
-------
R
--------------
F
D
L
L
--------
P
R
Y
M
L
I
L
G
T
I
Y
A
---------
L
T
S
---
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
-
V
L
I
T
Q
I
V
-
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
L
A
L
K
D
--
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
----
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
-
P
D
A
--
V
---
E
L
R
E
V
----
R
-
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-------
K
K
--
P
-
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
-
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
Y
---
3
PsiBlast_PDB
84.61
42%
-
- C1 -
-
4Q4H
-
Y288_THEMA
B:
[24-591]
---------
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
-------
R
--------------
F
D
L
L
--------
P
R
Y
M
L
I
L
G
T
I
Y
A
---------
L
T
S
---
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
-
V
L
I
T
Q
I
V
-
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
L
A
L
K
D
--
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
----
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
-
P
D
A
--
V
---
E
L
R
E
V
----
R
-
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-------
K
K
--
P
-
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
-
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
Y
---
98
HHSearch
84.30
42%
-
- C1 -
-
4Q4H
-
Y288_THEMA
B:
[22-590]
-------
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
---------------------
F
D
L
L
--------
P
R
Y
M
L
I
L
G
T
I
Y
A
---------
L
T
S
---
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
-
V
L
I
T
Q
I
V
-
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
L
A
L
K
D
--
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
----
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
---
V
---
E
L
R
E
V
----
R
-
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-------
K
K
--
P
-
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
-
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
----
20
PsiBlast_PDB
70.63
30%
0
- C- -
-
4M1M
-
MDR1A_MOUSE
A:
[52-679]
--------------------------
V
G
T
L
A
A
I
I
H
G
V
A
L
P
L
M
M
L
I
F
G
D
M
T
D
S
F
A
S
V
G
Q
V
-----
S
K
QSTQM
S
E
A
D
K
R
A
M
F
A
K
L
E
E
E
M
T
T
Y
A
Y
Y
Y
T
G
I
G
A
G
V
L
I
---------
V
A
Y
I
Q
-
V
S
F
W
C
L
A
------
A
G
R
Q
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
-
G
L
S
A
G
I
W
-
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
---
K
K
E
L
E
R
Y
N
N
N
L
-
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
VGQA
S
P
N
I
E
------
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
---
K
P
S
I
-
D
S
F
S
K
S
G
H
K
P
D
N
I
----
Q
-
G
N
L
E
F
K
N
I
H
F
S
Y
-
P
S
-------
R
K
EV
Q
-
I
L
-
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
-
R
E
-
D
-
V
-
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
-
R
E
K
G
I
Y
F
K
L
V
M
T
Q
----
8
PsiBlast_PDB
70.19
30%
-
- C1 -
-
3B5X
-
MSBA_VIBCH
A:
[11-580]
--------
Q
T
F
K
R
L
W
T
Y
I
R
L
Y
K
A
G
L
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
L
L
D
E
G
F
G
N
A
E
S
-----
N
--------------
F
L
R
I
--------
L
P
F
M
I
L
--
G
L
M
F
---------
V
R
G
---
L
S
G
F
A
S
S
Y
C
L
S
W
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
S
R
A
L
V
S
I
V
R
E
G
A
S
I
I
G
L
L
T
L
M
F
W
N
S
W
Q
L
S
L
V
L
I
V
V
A
P
V
V
A
F
A
I
S
F
V
S
-
K
R
F
R
K
I
S
R
N
-
M
Q
T
A
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
M
R
Q
Q
T
M
K
L
V
S
A
Q
S
I
A
-
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
---
A
S
V
D
S
I
R
A
--
E
L
T
P
G
T
F
T
--
V
V
F
S
A
M
F
G
L
M
--
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
M
D
L
E
T
E
R
----
D
N
G
K
Y
---
E
A
E
R
V
----
N
-
G
E
V
D
V
K
D
V
T
F
T
Y
-
Q
G
-------
K
E
--
K
P
A
L
-
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
A
E
G
-
E
-
Y
-
T
R
E
Q
I
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Q
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
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V
I
G
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N
G
T
S
L
S
G
G
Q
R
Q
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A
I
A
R
A
L
L
R
D
A
P
-
V
L
I
L
D
E
A
T
S
A
L
D
T
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S
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R
A
I
Q
A
A
L
D
E
L
Q
K
N
K
T
V
L
V
I
A
H
R
L
S
T
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Q
A
D
E
I
L
V
V
D
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G
E
I
I
E
R
G
R
H
A
D
L
L
-
A
Q
D
G
A
Y
A
Q
L
H
R
I
Q
F
---
91
HHSearch
70.17
26%
-131
- C1 -
-
5MKK
-
?
B:
[4-569]
-----
S
A
A
P
L
L
R
R
L
W
P
Y
V
G
R
Y
R
W
R
Y
L
W
A
V
L
A
G
L
V
S
I
F
F
F
V
L
T
P
Y
F
L
R
L
A
V
D
A
V
Q
A
G
R
-------
G
-----------------
F
--------
G
V
Y
A
L
A
I
V
A
S
A
A
---------
L
S
G
---
L
L
S
Y
A
M
R
R
L
A
V
V
A
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-
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A
L
L
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G
F
A
F
L
T
V
L
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---
G
G
A
M
V
V
R
G
--
E
L
S
V
G
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F
N
A
Y
L
A
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----
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R
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L
-
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L
---
A
L
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L
----
S
-
G
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V
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F
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G
V
G
L
K
R
-
D
G
--------
R
--
W
-
L
L
-
R
G
L
T
L
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A
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F
L
F
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L
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I
A
F
G
-
L
D
-
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-
V
-
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R
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W
A
A
R
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T
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G
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L
A
R
A
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R
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K
-
I
L
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D
D
A
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S
A
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A
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L
G
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Q
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T
L
L
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S
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W
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G
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G
T
H
E
S
L
L
-
Q
A
G
G
L
Y
A
E
M
D
-------
87
HHSearch
68.62
29%
-
- C1 -
-
3B5X
-
MSBA_VIBCH
A:
[10-581]
-------
W
Q
T
F
K
R
L
W
T
Y
I
R
L
Y
K
A
G
L
V
V
S
T
I
A
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V
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N
A
A
A
D
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Y
M
I
S
L
L
K
P
L
L
D
E
G
F
G
N
A
E
---------------------
S
N
F
L
--------
R
I
L
P
F
M
I
L
G
L
M
F
---------
V
R
G
---
L
S
G
F
A
S
S
Y
C
L
S
W
V
S
G
N
V
V
M
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R
R
L
F
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A
L
F
A
V
L
F
L
---
A
S
V
D
S
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R
A
--
E
L
T
P
G
T
F
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V
V
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A
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G
L
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----
R
P
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A
L
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V
T
S
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F
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R
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Q
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L
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G
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L
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R
D
N
G
K
Y
-------
E
A
E
R
V
----
N
-
G
E
V
D
V
K
D
V
T
F
T
Y
-
Q
G
K------
E
K
--
P
-
A
L
-
S
H
V
S
F
S
I
P
Q
G
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A
L
V
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S
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A
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N
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A
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A
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G
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L
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A
A
L
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K
T
V
L
V
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A
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R
L
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T
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A
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L
V
V
D
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E
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G
R
H
A
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L
L
-
A
Q
D
G
A
Y
A
Q
L
H
R
I
Q
F
G
--
95
HHSearch
62.59
27%
-
- C1 -
-
4Q4H
-
?
A:
[-2-569]
---------
G
S
K
T
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
---------------------
F
S
L
V
--------
L
K
T
G
I
L
M
L
I
V
A
L
---------
I
G
A
---
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
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S
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S
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V
N
R
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H
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L
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L
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L
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V
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L
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M
I
A
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W
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---
G
G
V
L
V
R
N
N
--
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
----
F
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M
M
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N
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L
N
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A
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L
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A
--
L
---
A
L
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----
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G
S
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S
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V
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Y
-
F
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N------
T
D
--
P
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L
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G
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N
F
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V
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L
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R
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P
Q
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V
L
F
S
G
T
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N
L
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W
G
-
R
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D
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A
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D
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A
A
K
I
A
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L
P
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G
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D
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V
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G
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G
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A
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L
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L
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D
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S
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L
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C
T
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I
T
Q
K
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L
L
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I
L
V
L
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L
L
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E
H
C
K
P
Y
R
E
I
Y
E
S
Q
F
---
13
PsiBlast_PDB
62.45
29%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
A:
[11-580]
--------
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
------
R
--------------
S
V
L
L
--------
W
M
P
L
V
V
I
G
L
M
I
L
---------
R
G
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Y
I
S
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Y
C
I
S
W
V
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----
V
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M
R
R
R
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F
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M
M
G
M
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A
F
F
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L
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V
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V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
-
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
---
12
PsiBlast_PDB
62.40
29%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
A:
[11-580]
--------
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
------
R
--------------
S
V
L
L
--------
W
M
P
L
V
V
I
G
L
M
I
L
---------
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
----
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
-
S
I
A
I
R
V
V
-
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
---
A
S
F
P
S
V
M
D
--
S
L
T
A
G
T
I
T
--
V
V
F
S
S
M
I
A
L
M--
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
-----------
E
G
K
R
V
IDRA
T
-
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
-------
R
E
V-
P
-
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
-
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
-
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
---
15
PsiBlast_PDB
61.29
29%
-
- C1 -
-
3B5W
-
MSBA_ECOLI
A:
[11-580]
--------
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
V
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
------
R
--------------
S
V
L
V
--------
W
M
P
L
V
V
I
G
L
M
I
L
---------
R
G
I
T
S
Y
V
S
S
Y
C
I
S
W
V
S
G
K
V
----
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
S
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
I
V
L
A
P
I
V
-
S
I
A
I
R
V
V
-
S
K
R
F
R
N
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
R
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
---
A
S
F
P
S
V
M
D
--
S
L
T
A
G
T
I
T
--
V
V
F
S
S
M
I
A
L
M
--
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
T
I
L
D
S
E
Q
E
K
----
D
E
G
K
R
---
V
I
E
R
A
----
T
-
G
D
V
E
F
R
N
V
T
F
T
Y
-
P
G
-------
R
D
V-
P
-
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
E
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
-
Q
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
V
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
K
A
D
E
I
V
V
V
E
D
G
V
I
V
E
R
G
T
H
N
D
L
L
-
E
H
R
G
V
Y
A
Q
L
H
K
M
Q
F
---
100
HHSearch
61.15
32%
-9
- C1 -
-
5MKK
-
?
A:
[10-592]
------
D
R
A
L
F
A
R
I
L
R
Y
V
W
P
Y
R
L
Q
V
V
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
W
A
I
D
L
A
L
V
P
T
E
P
R
P
L
A
E
R
--------------
F
H
L
L
--------
L
W
I
S
L
G
F
L
A
V
R
A
---------
V
H
F
---
A
A
T
Y
G
E
T
Y
L
I
Q
W
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
N
P
V
G
R
L
M
T
R
V
T
S
D
V
D
A
I
N
Q
F
I
T
G
G
L
V
G
V
I
A
D
L
F
T
L
V
G
L
L
G
F
M
L
F
L
S
P
K
L
T
L
V
V
L
L
V
A
P
V
L
-
L
A
V
T
T
W
V
-
R
L
G
M
R
S
A
Y
R
E
M
R
L
R
L
A
R
V
N
A
A
L
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
D
R
L
N
R
D
L
F
R
A
W
V
E
I
I
R
W
F
A
L
F
-
F
P
V
V
G
F
L
G
D
F
A
V
A
S
L
V
Y
Y
---
G
G
G
E
V
V
R
G
--
A
V
S
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
----
Q
P
L
Q
D
L
S
D
K
F
N
L
F
Q
G
A
M
A
S
A
E
R
I
F
G
V
L
D
T
E
E
E
L
K
D
P
E
D
P
--
T
---
P
I
R
G
F
----
R
-
G
E
V
E
F
R
D
V
W
L
A
Y
-
T
P
KGVEPTE
K
D
--
W
-
V
L
-
K
G
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
D
P
Q
R
G
C
V
F
L
D
G
V
D
V
R
R
Y
R
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
L
F
S
G
T
V
L
D
N
L
R
L
F
-
D
P
-
S
-
V
-
P
P
E
R
V
E
E
V
A
R
F
L
G
A
H
E
F
I
L
R
L
P
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
I
L
L
I
L
D
E
A
T
A
S
V
D
S
E
T
E
K
R
L
Q
E
A
L
Y
K
A
M
E
G
R
T
S
L
I
I
A
H
R
L
S
T
I
R
H
V
D
R
I
L
V
F
R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
-
A
K
G
G
Y
Y
A
A
L
Y
-------
85
HHSearch
59.07
29%
-41
- C1 -
-
3B60
2
MSBA_SALTY
D:
[10-581]
-------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
---------------------
R
S
V
L
--------
L
W
M
P
L
V
V
I
G
L
M
I
---------
L
R
G
---
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
-
S
I
A
I
R
V
V
-
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
---
A
S
F
P
S
V
M
D
--
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
----
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
R
-------
V
I
D
R
A
----
T
-
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
R------
E
V
--
P
-
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
E
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
-
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
--
6
PsiBlast_PDB
58.91
33%
-11
- C1 -
-
2ONJ
2
Y1866_STAAM
A:
[2-576]
----------
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
-----
T
--------------
T
D
E
K
--------
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
---
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
----
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
-
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
-
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
-
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
---
G
A
Y
L
A
I
S
G
--
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
----
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
---
E
D
Y
D
I
K
N
G
V
G
A
---
Q
P
I
E
I
----
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-------
E
A
--
P
-
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
-
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
-
A
K
Q
G
A
Y
E
H
L
Y
S
I
Q
----
21
PsiBlast_CBE
58.88
33%
-12
- C1 -
-
2ONJ
2
Y1866_STAAM
B:
[2-576]
----------
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
-----
T
--------------
T
D
E
K
--------
V
H
H
L
T
I
A
I
G
I
A
L
FIFVIVRPP
I
E
F
---
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
----
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
-
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
-
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
-
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
---
G
A
Y
L
A
I
S
G
--
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
----
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
---
E
D
Y
D
I
K
N
G
V
G
A
---
Q
P
I
E
I
----
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-------
E
A
--
P
-
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
-
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
-
A
K
Q
G
A
Y
E
H
L
Y
S
I
Q
----
5
PsiBlast_PDB
58.75
33%
-13
- C1 -
-
2HYD
2
Y1866_STAAM
A:
[2-576]
----------
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
-----
T
--------------
T
D
E
K
--------
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
---
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
----
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
-
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
-
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
-
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
---
G
A
Y
L
A
I
S
G
--
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
----
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
---
E
D
Y
D
I
K
N
G
V
G
A
---
Q
P
I
E
I
----
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-------
E
A
--
P
-
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
-
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
-
A
K
Q
G
A
Y
E
H
L
Y
S
I
Q
----
106
Fugue
58.65
28%
-41
- C1 -
-
3B60
2
MSBA_SALTY
A:
[10-581]
-------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
---------------------
R
S
V
L
--------
L
W
M
P
L
V
V
I
G
L
M
I
---------
L
R
G
---
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
-
S
I
A
I
R
V
V
-
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
---
A
S
F
P
S
V
M
D
--
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
----
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
R
-------
V
I
D
R
A
----
T
-
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
-------
E
V
--
P
-
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
-
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
-
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
--
73
PsiBlast_CBE
40.60
39%
-28
- C1 -
-
1XEF
2
HLYBP_ECOLX
A:
[2-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-------
D
S
--
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
-
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
----
58
PsiBlast_CBE
40.49
40%
-26
- C1 -
-
2PMK
1
A:
[4-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-------
D
S
--
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
-
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
----
68
PsiBlast_CBE
40.00
39%
-23
- C1 -
-
2FGJ
2
HLYBP_ECOLX
A:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-------
D
S
--
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
-
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
----
66
PsiBlast_CBE
39.91
39%
-25
- C1 -
-
2FGJ
2
HLYBP_ECOLX
C:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-------
D
S
--
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
-
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
----
60
PsiBlast_CBE
38.74
39%
-24
- C1 -
-
2FGK
2
D:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-------
D
S
--
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
-
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
----
62
PsiBlast_CBE
38.04
39%
-23
- C1 -
-
2FGK
2
HLYBP_ECOLX
B:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-------
D
S
--
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
-
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
----
65
PsiBlast_CBE
37.52
39%
-19
- C1 -
-
2FGJ
2
D:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-------
D
S
--
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
-
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
----
63
PsiBlast_CBE
36.41
39%
-20
- C1 -
-
2FGK
2
HLYBP_ECOLX
A:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-------
D
S
--
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
-
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
----
61
PsiBlast_CBE
36.33
39%
-21
- C1 -
-
2FGK
2
HLYBP_ECOLX
C:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
-
K
P
-------
D
S
--
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
-
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
----