@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XWZ1: (2018-01-01 )
MVEMALKNVYKKYDNAENYSVTDFNLSIKDREFIVFVGPSGCGKSTTLRMIAGLEDISEGELNIGGKVMNDVAPKDRDIAMVFQNYALYPHMTVFDNMAFGLKLRKYDKADIKKRVDNAAEILGLTEYLKRKPAALSGGQRQRVALGRAIVRDAKVFLMDEPLSNLDAKLRVAMRAEIAKLHQRLETTTIYVTHDQTEAMTMADRIVIMKDGFIQQIGTPKEVYDTPVNMFVAGFIGSPAMNFFNVTLKNGVITDGHGLKLRIPEGKNKVLVEKGYEGKEVIFGIRPEDIHSEQVALEASPEAVVKSEVVVSELLGAETMLYTKTGSTEFISKVDARDFHKPGEIVDLAFNISKGHFFDKETEQVIKLP
Atome Classification :
(40 SA)
.........10.......--.20........30........40........50........60.....---...70------.....-----..-.---------------80........90......-..100........110.......120.......130---.-.......140.......150.......160.......170.......180....---.---..190.......200.......210.......220.......230.......240.......250--..----.--.-.-..260.......270.......---..280.......290....-..-.300....--...310.......320.......--330.......340.......350.......360.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
V
E
M
A
L
K
N
V
Y
K
K
YDNAEN--
Y
S
V
T
D
F
N
L
S
IKD
R
E
F
I
V
F
VGPSGCGKS
T
T
L
R
M
I
AG
L
E
DISEGELNIGG---
K
V
M
N
D------VAPKD-----
R
D
-
I
---------------
A
M
V
F
Q
NYALYP
H
M
T
V
F
DN-MAF
G
-
L
K
LRKY
D
K
A
D
I
K
K
R
V
D
N
A
A
E
I
L
G
L
T
E
Y
L
KR----K-PAALSGGQ
R
Q
R
V
A
L
G
R
A
I
VRD
A
K
V
F
L
MDEPLS
N
L
D
A
K
L
R
V
A
M
R
A
E
I
A
K
L
H
Q
RLE---
T
---
T
T
I
Y
V
THDQTE
A
M
T
M
A
D
R
I
V
I
MKD
G
F
I
Q
QIG
T
P
K
E
V
Y
DT
P
V
N
M
F
V
A
G
FIGSPA
M
N
F
F
N
V
T
LKN
G
V
--IT----D--G-H-
G
L
K
L
RIPEGK
N
K
V
--
L
V
EKGYE---G
K
E
V
I
F
G
IRPEDIHSE
Q
V
A
-LE-AS
P
E
A
V
V
K
--
S
E
V
V
V
S
E
LLGA
E
T
M
L
Y
TKTGS
T
E
--
F
I
S
KVDARDFHKPG
E
I
V
D
L
A
F
NISKGHFF
D
K
E
T
E
Q
V
IKLP
7
PsiBlast_PDB
89.55
50%
-111
- C2 -
-
1V43
-
?
A:
[10-372]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
F
T
----
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
---
R
D
V
T
Y
------
L
P
P
K
D
-----
R
N
-
I
---------------
S
M
V
F
Q
------
H
M
T
V
Y
E
N
-
I
A
F
P
-
L
--
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
N
R
----
Y
-
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
---
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
D
G
Y
--
L
-----
E
--
G
-
R
-
G
F
R
I
E
L
P
Q
--
M
D
L
--
L
--
K
D
Y
V
---
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
G
V
------
H
M
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
E
L
--
V
K
V
K
L
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
A
I
---
113
HHSearch
87.29
51%
-96
- C2 -
-
1V43
-
?
A:
[10-372]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
--
F
--
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
---
R
D
V
T
Y
------
L
P
P
K
D
-----
R
N
-
I
---------------
S
M
V
F
Q
------
H
M
T
V
Y
E
N
-
I
A
F
P
-
L
--
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
N
R
----
Y
-
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
---
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
D
G
Y
--
L
E
----
G
----
R
-
G
F
R
I
E
L
P
Q
--
M
----
D
L
L
K
D
Y
V
---
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
G
V
----H
M
K
R
T
A
R
L
I
--
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
E
L
--
V
K
V
K
L
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
A
I
---
6
PsiBlast_PDB
86.08
50%
-106
- C2 -
-
1VCI
1
?
A:
[10-372]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
F
T
----
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
---
R
D
V
T
Y
------
L
P
P
K
D
-----
R
N
-
I
---------------
S
M
V
F
Q
------
H
M
T
V
Y
E
N
-
I
A
F
P
-
L
--
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
N
R
----
Y
-
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
---
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
D
G
Y
--
L
-----
E
--
G
-
R
-
G
F
R
I
E
L
P
Q
--
M
D
L
--
L
--
K
D
Y
V
---
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
G
V
------
H
M
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
E
L
--
V
K
V
K
L
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
A
I
---
4
PsiBlast_PDB
84.40
51%
-80
- C2 -
-
4XTC
-
?
S:
[2-362]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
--
K
T
--
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
---
R
V
I
N
D
------
L
A
P
K
D
-----
R
D
-
V
---------------
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
-
I
S
F
G
-
L
R
L
K
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
L
L
E
R
----
K
-
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
---
T
---
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
---
A
--
V
D
----
S
--
T
-
Q
-
H
V
E
L
---
N
G
G
N
R
I
SL
L
P
R
A
G
T
H
LAP
G
Q
E
V
V
F
G
I
R
P
E
D
V
T
L
D
G
V
---
E
-
G
S
E
R
A
Q
I
K
--
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
S
--
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
I
---
3
PsiBlast_PDB
84.06
51%
-79
- C2 -
-
4XIG
-
?
S:
[2-362]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
--
K
T
--
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
---
R
V
I
N
D
------
L
A
P
K
D
-----
R
D
-
V
---------------
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
-
I
S
F
G
-
L
R
L
K
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
L
L
E
R
----
K
-
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
---
T
---
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
---
A
--
V
D
----
S
--
T
-
Q
-
H
V
E
L
---
N
G
G
N
R
I
SL
L
P
R
A
G
T
H
LAP
G
Q
E
V
V
F
G
I
R
P
E
D
V
T
L
D
G
V
---
E
-
G
S
E
R
A
Q
I
K
--
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
S
--
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
I
---
1
PsiBlast_PDB
83.78
51%
-79
- C2 -
-
4TQU
-
?
S:
[2-362]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
--
K
T
--
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
---
R
V
I
N
D
------
L
A
P
K
D
-----
R
D
-
V
---------------
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
-
I
S
F
G
-
L
R
L
K
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
L
L
E
R
----
K
-
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
---
T
---
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
---
A
--
V
D
----
S
--
T
-
Q
-
H
V
E
L
---
N
G
G
N
R
I
SL
L
P
R
A
G
T
H
LAP
G
Q
E
V
V
F
G
I
R
P
E
D
V
T
L
D
G
V
---
E
-
G
S
E
R
A
Q
I
K
--
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
S
--
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
I
---
106
HHSearch
82.39
43%
-113
- C2 -
-
2IT1
-
?
A:
[1-357]
M
V
E
I
K
L
E
N
I
V
K
K
F
G
N
--
F
--
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
---
K
D
V
T
E
------
L
P
P
K
D
-----
R
N
-
V
---------------
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
-
I
A
F
P
-
L
E
L
R
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
R
----
Y
-
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
---
I
---
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
P
P
M
N
F
V
E
A
K
V
E
D
G
K
--
L
V
----
I
--
T
-
E
-
K
S
K
L
P
I
P
K
Q
Y
--
V
--
E
I
V
K
E
T
G
---
I
T
E
V
I
I
G
F
R
P
H
D
A
E
I
V
K
G
E
-
G
------
E
G
I
V
--
G
E
V
Y
S
F
E
P
L
G
R
E
Q
I
V
T
V
S
V
N
D
S
I
--
V
K
V
F
A
P
E
G
E
H
F
S
F
G
E
K
V
T
I
K
V
K
E
E
L
L
V
L
F
D
K
K
T
E
K
A
L
---
17
PsiBlast_PDB
81.45
50%
-104
- C2 -
-
3PUV
2
MALK_ECOLI
A:
[2-322]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
N
D
------
T
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
----
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
--
I
-----
D
--
Q
-
V
-
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
--
L
P
V
E
S
R
D
VQV
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
-------
D
V
I
L
E
--
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
--------------------------------------------
20
PsiBlast_PDB
80.96
50%
-104
- C2 -
-
3RLF
2
MALK_ECOLI
A:
[2-322]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
N
D
------
T
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
----
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
--
I
-----
D
--
Q
-
V
-
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
--
L
P
V
E
S
R
D
VQV
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
-------
D
V
I
L
E
--
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
--------------------------------------------
99
HHSearch
80.93
52%
-78
- C2 -
-
4TQU
-
?
T:
[2-363]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
K
--
T
--
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
---
R
V
I
N
D
------
L
A
P
K
D
-----
R
D
-
V
---------------
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
-
I
S
F
G
-
L
R
L
K
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
L
L
E
R
----
K
-
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
---
T
---
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
A
V
D
S
TQ
H
V
----
E
--
L
N
G
-
G
N
R
I
S
L
L
P
R
A
------
G
T
H
L
A
P
---
G
Q
E
V
V
F
G
I
R
P
E
D
V
T
L
D
G
V
E
----
G
S
E
R
A
Q
I
K
--
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
S
--
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
I
Y
--
97
HHSearch
80.83
47%
-86
- C2 -
-
3RLF
2
MALK_ECOLI
A:
[2-365]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
N
D
------
T
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
----
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
--
I
D
Q
V
Q
V
E
L
P
M
-
P
N
R
Q
Q
V
W
L
P
V
E
-------
S
R
D
V
Q
V
---
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
-------
D
V
I
L
E
--
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
-
19
PsiBlast_PDB
80.61
50%
-104
- C2 -
-
3PUX
2
MALK_ECOLI
A:
[2-322]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
N
D
------
T
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
----
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
--
I
-----
D
--
Q
-
V
-
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
--
L
P
V
E
S
R
D
VQV
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
-------
D
V
I
L
E
--
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
--------------------------------------------
22
PsiBlast_CBE
80.56
50%
-102
- C2 -
-
4KI0
3
MALK_ECOLI
A:
[2-322]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
N
D
------
T
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
----
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
--
I
-----
D
--
Q
-
V
-
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
--
L
P
V
E
S
R
D
VQV
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
-------
D
V
I
L
E
--
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
--------------------------------------------
18
PsiBlast_PDB
80.39
50%
-102
- C2 -
-
3PUW
2
MALK_ECOLI
A:
[2-322]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
N
D
------
T
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
----
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
--
I
-----
D
--
Q
-
V
-
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
--
L
P
V
E
S
R
D
VQV
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
-------
D
V
I
L
E
--
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
--------------------------------------------
14
PsiBlast_PDB
80.08
50%
-103
- C2 -
-
3PUY
2
MALK_ECOLI
A:
[2-322]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
N
D
------
T
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
----
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
--
I
-----
D
--
Q
-
V
-
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
--
L
P
V
E
S
R
D
VQV
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
-------
D
V
I
L
E
--
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
--------------------------------------------
34
PsiBlast_CBE
79.98
50%
-99
- C2 -
-
2R6G
2
MALK_ECOLI (first)
A:
[2-322]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
N
D
------
T
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
----
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
--
I
-----
D
--
Q
-
V
-
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
--
L
P
V
E
S
R
D
VQV
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
-------
D
V
I
L
E
--
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
--------------------------------------------
24
PsiBlast_CBE
79.40
50%
-108
- C2 -
-
3PUZ
1
MALK_ECOLI
B:
[2-322]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
N
D
------
T
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
----
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
--
I
-----
D
--
Q
-
V
-
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
--
L
P
V
E
S
R
D
VQV
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
-------
D
V
I
L
E
--
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
--------------------------------------------
23
PsiBlast_CBE
78.68
50%
-103
- C2 -
-
3RLF
2
MALK_ECOLI
B:
[2-323]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
N
D
------
T
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
----
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
--
I
-----
D
--
Q
-
V
-
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
--
L
P
V
E
S
R
D
VQV
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
-------
D
V
I
L
E
--
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
--------------------------------------------
21
PsiBlast_CBE
78.00
50%
-103
- C2 -
-
4KI0
2
MALK_ECOLI
B:
[2-322]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
N
D
------
T
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
----
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
--
I
-----
D
--
Q
-
V
-
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
--
L
P
V
E
S
R
D
VQV
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
-------
D
V
I
L
E
--
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
--------------------------------------------
33
PsiBlast_CBE
77.78
50%
-105
- C2 -
-
2R6G
2
MALK_ECOLI (first)
B:
[2-322]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
---
K
R
M
N
D
------
T
P
P
A
E
-----
R
G
-
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
----
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
--
I
-----
D
--
Q
-
V
-
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
--
L
P
V
E
S
R
D
VQV
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
-------
D
V
I
L
E
--
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
--------------------------------------------
102
HHSearch
75.72
55%
19
- C2 -
-
2D62
1
?
A:
[4-375]
M
A
E
V
K
L
I
N
I
W
K
R
F
G
D
--
V
--
T
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
---
N
L
V
A
D
PEKG
V
F
V
P
P
K
E
-----
R
D
-
V
---------------
A
M
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
-
I
A
F
P
-
L
K
L
R
K
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
T
E
L
L
N
R
----
K
-
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
---
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
S
P
P
M
N
F
L
D
A
T
I
T
D
D
G
--
F
L
----
D
--
F
-
G
-
E
F
K
L
K
L
L
Q
D
Q
F
E
V
--
L
E
E
E
N
M
V
---
G
K
E
V
I
F
G
I
R
P
E
D
V
H
D
A
S
F
T
H
I
D
-
V
P
E
E
N
T
V
K
--
A
T
V
D
I
I
E
N
L
G
G
E
K
I
V
H
L
R
R
G
N
I
S
--
F
T
A
K
F
P
K
E
S
K
V
R
E
G
D
E
V
S
V
V
F
D
M
K
K
I
H
I
F
R
K
D
T
E
K
A
I
F
--
5
PsiBlast_PDB
75.14
51%
19
- C2 -
-
2D62
1
?
A:
[6-374]
--
E
V
K
L
I
N
I
W
K
R
F
G
D
V
----
T
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
---
N
L
V
A
D
PEKG
V
F
V
P
P
K
E
-----
R
D
-
V
---------------
A
M
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
-
I
A
F
P
-
L
K
L
R
K
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
T
E
L
L
N
R
----
K
-
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
---
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
S
P
P
M
N
F
L
D
A
T
I
T
D
D
G
--
F
L
----
D
--
F
-
G
-
E
F
K
L
K
L
L
Q
D
Q
F
E
V
--
L
E
E
E
N
M
V
---
G
K
E
V
I
F
G
I
R
P
E
D
V
H
D
A
S
F
T
H
I
D
-
V
P
E
E
N
T
V
K
--
A
T
V
D
I
I
E
N
L
G
G
E
K
I
V
H
L
R
R
G
N
I
S
--
F
T
A
K
F
P
K
E
S
K
V
R
E
G
D
E
V
S
V
V
F
D
M
K
K
I
H
I
F
R
K
D
T
E
K
A
I
---
79
PsiBlast_CBE
42.10
33%
-10
- C2 -
-
4YMV
1
?
A:
[4-224]
-----
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
N
N
GKVN--
I
N
K
V
R
-----
Q
K
-
V
---------------
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
-
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
----
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
K
E
V
L
N
V
M
K
Q
L
A
---
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
41.39
35%
-16
- C2 -
-
3C41
2
?
K:
[23-238]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INL
K
A
K
D
T
------
N
L
N
K
V
-----
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
----
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
40.21
33%
-14
- C2 -
-
4YMU
1
?
J:
[4-224]
-----
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
N
N
GKVN--
I
N
K
V
R
-----
Q
K
-
V
---------------
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
-
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
----
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
K
E
V
L
N
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
39.74
35%
-13
- C2 -
-
3C4J
2
?
B:
[44-259]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INL
K
A
K
D
T
------
N
L
N
K
V
-----
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
----
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
39.63
35%
-13
- C2 -
-
3C41
2
?
J:
[23-238]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INL
K
A
K
D
T
------
N
L
N
K
V
-----
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
----
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
39.51
33%
-12
- C2 -
-
4YMV
1
?
J:
[4-224]
-----
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
N
N
GKVN--
I
N
K
V
R
-----
Q
K
-
V
---------------
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
-
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
----
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
K
E
V
L
N
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
39.29
33%
-14
- C2 -
-
4YMU
1
?
A:
[4-224]
-----
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
N
N
GKVN--
I
N
K
V
R
-----
Q
K
-
V
---------------
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
-
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
----
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
K
E
V
L
N
V
M
K
Q
L
A
---
N
E
GM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
39.20
35%
-14
- C2 -
-
2OLK
1
?
D:
[44-259]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INL
K
A
K
D
T
------
N
L
N
K
V
-----
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
----
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
38.99
35%
-14
- C2 -
-
2Q0H
3
?
A:
[44-259]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INL
K
A
K
D
T
------
N
L
N
K
V
-----
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
----
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
38.81
35%
-13
- C2 -
-
2OLK
2
?
B:
[44-259]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INL
K
A
K
D
T
------
N
L
N
K
V
-----
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
----
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
38.11
35%
-8
- C2 -
-
2OLJ
3
?
A:
[44-259]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INL
K
A
K
D
T
------
N
L
N
K
V
-----
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
----
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
E
GM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
37.97
35%
-16
- C2 -
-
2Q0H
3
?
B:
[44-259]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INL
K
A
K
D
T
------
N
L
N
K
V
-----
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
----
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
E
GM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
37.95
35%
-14
- C2 -
-
3C4J
2
?
A:
[44-259]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INL
K
A
K
D
T
------
N
L
N
K
V
-----
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
----
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
E
GM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
37.63
35%
-11
- C2 -
-
2OLJ
2
?
B:
[44-259]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INL
K
A
K
D
T
------
N
L
N
K
V
-----
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
----
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
37.10
35%
-15
- C2 -
-
2OLK
1
?
A:
[44-259]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INL
K
A
K
D
T
------
N
L
N
K
V
-----
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
----
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
E
GM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
36.80
35%
-16
- C2 -
-
2OLK
1
?
C:
[44-259]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INL
K
A
K
D
T
------
N
L
N
K
V
-----
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
----
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
35.35
35%
28
- C2 -
-
3TIF
4
Y796_METJA
B:
[4-225]
-----
L
K
N
V
T
K
T
Y
K
M
G
E
E
II
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
---
I
K
T
N
D
------
L
D
D
D
E
LTKIR
R
D
K
I
---------------
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
-
V
E
L
P
-
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
FANH
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
---
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
23.08
31%
25
- C2 -
-
1B0U
1
HISP_SALTY
A:
[45-253]
---------------------------------------------
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
---
Q
N
I
N
L
------
V
R
D
K
D
-----
G
Q
-
L
KVAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
-
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
----
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
----
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
---
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------