@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XWZ6: (2018-01-01 )
MANGTDKKTYEAAVAAFIKENKPKRQVVYDDLSNQLATPFTLNADEMDKLIQKIEDAGISVVDENGDPSIHSLKSAEKKAEQAKTEDLSAPTGVKINDPVRMYLKEIGRVSLLTAEEEVALALKIEEGDQEAKQRLAEANLRLVVSIAKRYVGRGMQFLDLIQEGNMGLMKAVEKFDYRKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINKLIRIQRQLLQDLGREPTPEEIGAEMDLPTEKVREILKIAQEPVSLETPIGEEDDSHLGDFIEDQEATSPAEHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEEVGKVFGVTRERIRQIEAKALRKLRHPSRSKQLKDFLE
Atome Classification :
(62 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120....----------------------------------------------------------------------..----------------------------------------------------------------------.130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240..--.--....250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350....-...360........
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MANGTD
K
K
T
Y
E
A
A
V
A
A
F
I
KENKPK
R
Q
V
V
Y
D
D
LSNQLAT
P
F
TL
N
A
D
E
M
D
K
L
I
Q
K
I
E
D
AG
I
S
V
VDENGDP
S
I
H
S
L
K
S
A
E
K
K
A
E
Q
AKTEDLSAPTGVKIN
D
P
V
R
M
Y
L
K
EIGR
V
S
L
L
TAEE
E
V
A
L
A
L
K
IE----------------------------------------------------------------------EG----------------------------------------------------------------------
D
Q
E
A
K
Q
R
L
A
E
A
N
L
R
L
V
V
S
I
A
K
R
Y
VGR
G
M
Q
F
L
D
L
I
Q
EGN
M
G
L
M
K
A
V
E
K
F
D
Y
RKGFKF
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
I
ADQA
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
I
R
I
Q
R
Q
L
L
Q
D
LGREP
T
P
E
E
IGAEM--D--L
P
T
E
K
V
R
E
I
L
K
I
A
QEPVSLETPIGEED
D
S
H
L
G
D
F
I
E
D
QEATS
P
A
E
H
A
A
Y
E
L
L
K
E
Q
L
E
D
V
L
D
T
L
TDREE
N
V
L
R
L
R
FGLDDGRT
R
T
L
E
E
V
G
K
V
F
G
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
LR-HP
S
R
-
S
K
Q
L
K
D
F
LE
19
PsiBlast_PDB
77.15
69%
-122
- C4 -
-
4LK1
-
RPOD_ECOLI
F:
[375-612]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
20
PsiBlast_PDB
76.13
69%
-118
- C4 -
-
4LLG
-
RPOD_ECOLI
F:
[375-612]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
F
L
D
88
HHSearch
75.47
68%
56
- C4 -
-
4XLN
1
SIGA_THEAQ
L:
[2-346]
------------------------------------------------------------------------------------------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
I
D
L
A
R
K
V
E
----------------------------------------------------------------------
E
G
MEAIKKLSEATGLDQELIREVVRAKILGTARIQKIPGLKEKPDPKTVEEVDGKLKSLPKELKRYLHIARE
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
--
G
PG
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
-
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
21
PsiBlast_CBE
75.07
69%
-120
- C4 -
-
4KN4
1
RPOD_ECOLI
Y:
[375-609]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
---
17
PsiBlast_PDB
74.69
69%
-130
- C4 -
-
4KN4
1
RPOD_ECOLI
X:
[375-609]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
---
18
PsiBlast_PDB
74.45
69%
-127
- C4 -
-
4KN7
1
RPOD_ECOLI
X:
[375-609]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
---
15
PsiBlast_PDB
74.18
69%
-127
- C4 -
-
4JK2
-
RPOD_ECOLI
X:
[375-609]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
---
22
PsiBlast_CBE
74.15
69%
-118
- C4 -
-
4KMU
1
RPOD_ECOLI
Y:
[375-609]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
---
14
PsiBlast_PDB
73.99
69%
-122
- C4 -
-
4JK1
-
RPOD_ECOLI
X:
[375-609]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
---
16
PsiBlast_PDB
73.98
69%
-128
- C4 -
-
4KMU
-
RPOD_ECOLI
X:
[375-609]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
--
L
--
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
-
S
E
V
L
R
S
---
12
PsiBlast_PDB
73.18
57%
33
- C4 -
-
5TW1
-
?
F:
[163-466]
-------------------------------------------------------------------------------------------
A
-----
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
----------------------------------------------------------------------
A
G
LYATQKLAELAEKGEKLPVQQRRDMQWICRD---------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
--
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
E
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
9
PsiBlast_PDB
70.31
62%
42
- C4 -
-
5UHE
2
SIGA_MYCTU
F:
[226-528]
-------------------------------------------------------------------------------------------------
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
----------------------------------------------------------------------
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
W
I
C
R
D
---------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
7
PsiBlast_PDB
70.06
62%
39
- C4 -
-
5UHC
3
SIGA_MYCTU
F:
[226-528]
-------------------------------------------------------------------------------------------------
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
----------------------------------------------------------------------
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
W
I
C
R
D
---------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
5
PsiBlast_PDB
70.00
62%
41
- C4 -
-
5UHA
2
SIGA_MYCTU
F:
[226-528]
-------------------------------------------------------------------------------------------------
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
----------------------------------------------------------------------
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
W
I
C
R
D
---------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
4
PsiBlast_PDB
69.90
62%
43
- C4 -
-
5UH9
2
SIGA_MYCTU
F:
[226-528]
-------------------------------------------------------------------------------------------------
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
----------------------------------------------------------------------
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
W
I
C
R
D
---------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
86
HHSearch
69.77
41%
-103
- C4 -
-
5IPM
-
RPOS_ECOLI
F:
[53-325]
----------------------------------------------------------------------------------------------
R
V
L
D
A
T
Q
L
Y
L
G
E
I
G
Y
S
P
L
L
T
A
E
E
E
V
Y
F
A
R
R
A
L
----------------------------------------------------------------------
R
G
----------------------------------------------------------------------
D
V
A
S
R
R
R
M
I
E
S
N
L
R
L
V
V
K
I
A
R
R
Y
G
N
R
G
L
A
L
L
D
L
I
E
E
G
N
L
G
L
I
R
A
V
E
K
F
D
P
E
R
G
F
R
F
S
T
Y
A
T
W
W
I
R
Q
T
I
E
R
A
I
M
N
Q
T
R
T
I
R
L
P
I
H
I
V
K
E
L
N
V
Y
L
R
T
A
R
E
L
S
H
K
L
D
H
E
P
S
A
E
E
I
A
E
Q
L
--
D
--
K
P
V
D
D
V
S
R
M
L
R
L
N
E
R
I
T
S
V
D
T
P
L
G
G
D
S
E
K
A
L
L
D
I
L
A
D
E
K
E
N
G
P
E
D
T
T
Q
D
D
D
M
K
Q
S
I
V
K
W
L
F
E
L
N
A
K
Q
R
E
V
L
A
R
R
F
G
L
L
G
Y
E
A
A
T
L
E
D
V
G
R
E
I
G
L
T
R
E
R
V
R
Q
I
Q
V
E
G
L
R
R
L
R
-
E
I
L
Q
-
T
Q
G
L
N
I
E
--
11
PsiBlast_PDB
69.67
62%
40
- C4 -
-
5UHG
2
SIGA_MYCTU
F:
[226-528]
-------------------------------------------------------------------------------------------------
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
----------------------------------------------------------------------
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
W
I
C
R
D
---------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
-
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
1
PsiBlast_PDB
69.60
62%
39
- C4 -
-
5UH5
2
SIGA_MYCTU
F:
[226-528]
-------------------------------------------------------------------------------------------------
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
----------------------------------------------------------------------
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
W
I
C
R
D
---------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
2
PsiBlast_PDB
69.53
62%
41
- C4 -
-
5UH6
3
SIGA_MYCTU
F:
[226-528]
-------------------------------------------------------------------------------------------------
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
----------------------------------------------------------------------
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
W
I
C
R
D
---------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
65
PsiBlast_CBE
69.33
67%
0
- C- -
-
2A68
1
?
F:
[174-423]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
-----
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
3
PsiBlast_PDB
69.06
62%
43
- C4 -
-
5UH8
3
SIGA_MYCTU
F:
[226-528]
-------------------------------------------------------------------------------------------------
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
----------------------------------------------------------------------
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
W
I
C
R
D
---------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
31
PsiBlast_CBE
69.02
67%
-6
- C4 -
-
4XLR
1
SIGA_THEAQ
F:
[93-347]
---------------------------------------------------------------------------------------------------------------------
E
L
K
R
Y
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
27
PsiBlast_CBE
68.95
67%
5
- C4 -
-
5TJG
1
?
F:
[93-347]
---------------------------------------------------------------------------------------------------------------------
E
L
K
R
Y
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
38
PsiBlast_CBE
68.83
67%
-2
- C4 -
-
5I2D
1
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
8
PsiBlast_PDB
68.80
62%
42
- C4 -
-
5UHD
2
SIGA_MYCTU
F:
[226-528]
-------------------------------------------------------------------------------------------------
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
----------------------------------------------------------------------
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
W
I
C
R
D
---------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
--
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
29
PsiBlast_CBE
68.73
67%
6
- C4 -
-
4XLS
1
SIGA_THEAQ
F:
[93-347]
---------------------------------------------------------------------------------------------------------------------
E
L
K
R
Y
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
30
PsiBlast_CBE
68.54
67%
-4
- C4 -
-
4XLR
1
SIGA_THEAQ
L:
[93-347]
---------------------------------------------------------------------------------------------------------------------
E
L
K
R
Y
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
47
PsiBlast_CBE
68.53
67%
6
- C4 -
-
4OIR
3
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
32
PsiBlast_CBE
68.51
67%
-5
- C4 -
-
4XLN
1
SIGA_THEAQ
L:
[93-347]
---------------------------------------------------------------------------------------------------------------------
E
L
K
R
Y
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
6
PsiBlast_PDB
68.41
62%
43
- C4 -
-
5UHB
1
SIGA_MYCTU
F:
[226-528]
-------------------------------------------------------------------------------------------------
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
----------------------------------------------------------------------
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
W
I
C
R
D
---------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
--
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
10
PsiBlast_PDB
68.40
62%
44
- C4 -
-
5UHF
1
SIGA_MYCTU
F:
[226-528]
-------------------------------------------------------------------------------------------------
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
----------------------------------------------------------------------
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
W
I
C
R
D
---------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
G
R
E
P
T
P
E
E
L
A
K
E
M
--
D
--
I
T
P
E
K
V
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
F
I
E
D
S
E
A
V
V
A
V
D
A
V
S
F
T
L
L
Q
D
Q
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
G
L
T
D
G
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
-
H
P
S
R
-
S
Q
V
L
R
D
Y
L
D
56
PsiBlast_CBE
68.39
67%
1
- C4 -
-
4G7H
2
?
P:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
33
PsiBlast_CBE
68.35
67%
-1
- C4 -
-
4XLN
1
SIGA_THEAQ
F:
[93-347]
---------------------------------------------------------------------------------------------------------------------
E
L
K
R
Y
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
28
PsiBlast_CBE
68.33
67%
4
- C4 -
-
4XLS
1
SIGA_THEAQ
L:
[93-347]
---------------------------------------------------------------------------------------------------------------------
E
L
K
R
Y
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
N
L
P
S
P
V
E
A
A
A
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
54
PsiBlast_CBE
68.23
67%
3
- C4 -
-
4G7O
2
?
P:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
45
PsiBlast_CBE
68.08
67%
5
- C4 -
-
5D4C
1
?
P:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
50
PsiBlast_CBE
67.96
67%
4
- C4 -
-
4OIO
2
?
F:
[194-441]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
--
51
PsiBlast_CBE
67.90
67%
4
- C4 -
-
4OIN
2
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
52
PsiBlast_CBE
67.82
67%
-2
- C4 -
-
4G7Z
2
?
P:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
61
PsiBlast_CBE
67.67
67%
4
- C4 -
-
4Q4Z
1
?
F:
[174-423]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
37
PsiBlast_CBE
67.58
67%
7
- C4 -
-
5I2D
1
?
Q:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
59
PsiBlast_CBE
67.56
67%
-2
- C4 -
-
5VO8
2
?
F:
[174-423]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
44
PsiBlast_CBE
67.53
67%
5
- C4 -
-
5D4D
1
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
48
PsiBlast_CBE
67.45
67%
6
- C4 -
-
4OIQ
2
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
55
PsiBlast_CBE
67.26
67%
12
- C4 -
-
4G7O
2
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
53
PsiBlast_CBE
67.21
67%
14
- C4 -
-
4G7Z
2
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
41
PsiBlast_CBE
67.18
67%
10
- C4 -
-
5D4E
1
?
P:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
57
PsiBlast_CBE
67.14
67%
10
- C4 -
-
4G7H
2
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
49
PsiBlast_CBE
67.10
67%
9
- C4 -
-
4OIP
2
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
46
PsiBlast_CBE
66.30
67%
10
- C4 -
-
5D4C
1
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
42
PsiBlast_CBE
66.27
67%
-0
- C4 -
-
5D4E
1
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
39
PsiBlast_CBE
66.10
67%
-2
- C4 -
-
5E18
1
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
-----------
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
60
PsiBlast_CBE
64.90
67%
-1
- C4 -
-
4Q5S
1
?
F:
[174-422]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
-------
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
-
40
PsiBlast_CBE
64.21
67%
8
- C4 -
-
5E17
2
?
F:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
---------
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
43
PsiBlast_CBE
62.46
67%
-31
- C4 -
-
5D4D
1
?
P:
[194-443]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
-------
R
E
A
M
V
L
K
L
-----------------------
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
D
74
PsiBlast_CBE
51.43
70%
-155
- C4 -
-
3UGO
1
SIGA_THEAQ
A:
[102-184]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
51.11
70%
-77
- C4 -
-
4KI2
1
SIGA_THEAQ
B:
[102-239]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
GP
G
--
W
D
A
K
R
V
E
E
T
L
K
I
A
-----------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
51.06
70%
-154
- C4 -
-
4KI2
1
SIGA_THEAQ
A:
[102-183]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
49.90
70%
-151
- C4 -
-
3UGP
1
SIGA_THEAQ
A:
[102-184]
--------------------------------------------------------------------------------------------------------------------------
L
H
I
A
----------------------------------------------------------------------
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
48.91
71%
22
- C4 -
-
3UGO
1
SIGA_THEAQ
A:
[5-184]
-----------------------------------------------------------------------------------------------
T
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
I
D
L
A
R
K
V
E
E
G
M
E
A
I
K
K
L
S
E
A
T
GLD
Q
E
L
I
R
E
V
V
R
A
K
I
LGTARIQKIPGLKEKPD
P
K
T
V
E
E
V
D
G
K
L
K
S
LP
K
E
L
K
R
Y
L
H
I
A
R
E
----------------------------------------------------------------------
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
41.45
65%
-61
- C4 -
-
1KU7
2
SIGA_THEAQ
A:
[2-73]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
M
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
-
T
R
K
L
R
D
F
L
E
79
PsiBlast_CBE
40.44
70%
-80
- C4 -
-
3N97
2
SIGA_THEAQ
A:
[9-61]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
L
S
E
R
E
A
M
V
L
K
M
R
K
G
L
I
D
G
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
R
-
H
P
------------