@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XX11: (2018-01-01 )
MRKVIIDCDPGIDDTLALSLAVKSPDIEVVAITVVCGNVPADIGTQNVLKCLERCDRLDIPVYQGMEKPLKQPFISAQDTHGMDGLGETNFPMILRKQAEPLHAVDFLADYFKEKTNTSVIALGPLTNIASALKVNPNIGKHMERFVSMGGTYKSHGNCSPVAEYNYWCDPEAASYVFENLKQTIEMVGLDVTREIVLTPTILEYCCQMNPEEGEYLKAITRFYFDFHWKQERILGCVINDPLAVAYFIEEAICEGFKSFTAVETQGISRGQTLVDRYEFWQKPANSKIMTKVDTRLFFRKFLTVLLNAQEETIMKDLERLKMG
Atome Classification :
(28 SA)
.........10........20........30........40........50........60-.........70...-....-.80........90-.....-...100.-..--......110.--...--.--.--.-----.120.......130.......140.-----..-----....150.......160.......170.......180..--.......190.......200.......210------------....---------------------.....220-----------.......230..--......240.......250...-.-.-...260..-...-.-.270....-...280-----.....------....290.......300.......310.......320..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
R
K
V
I
I
DCDPGIDD
T
L
A
L
S
L
A
VKSP
D
I
E
V
V
A
I
T
V
V
CGNVPADI
G
T
Q
N
V
L
K
C
L
E
R
CDRLD
I
--
P
V
Y
Q
G
M
E
K
P
L
KQPF-ISAQ-DTHGMDGLGETNF-
P
M
I
L
R-KQAE--P-
L
H
--
A
V
D
F
L
A
D
-
Y
F
--
K
EK--T--N--
T
-----
S
V
I
A
LG
P
L
T
N
I
A
S
A
LKVNP
N
I
G
K
H
M
-----
E
R
-----
F
V
SMGGTYKSHGNCSPVAEYNYWCD
P
E
A
A
S
Y
V
F
E
N
--
L
K
--
Q
T
I
E
M
V
G
L
D
V
T
R
E
I
VLT
P
T
I
L
E
Y
C
CQMN--------------PEE
G
---------------------
E
Y
L
K
A
I
T
R
-----------
F
Y
F
D
FHWKQ-
E
R
--
I
L
G
C
VIND
P
L
A
V
A
Y
F
I
E
-
E
A
I
C
-
E
-
G
-
F
K
S
F
T
A
V
E
-TQG-I-SR
G
Q
T
L
V
D
-
R
Y
E
F
-------
W
QKPA------NSK
I
M
T
K
V
D
T
R
L
F
F
R
K
F
L
T
V
L
LNA
Q
E
E
T
I
M
K
D
L
E
R
LKMG
1
PsiBlast_PDB
91.06
35%
-57
- C5 -
-
1EZR
-
IUNH_LEIMA
A:
[3-309]
-
R
K
I
I
L
D
C
D
P
G
I
D
D
A
V
A
I
F
L
A
H
G
N
P
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
S
L
E
K
V
T
Q
N
A
R
L
V
A
D
V
A
G
I
V
G
V
--
P
V
A
A
G
C
T
K
P
L
V
R
G
V
-
R
N
A
S
-
H
I
H
G
E
T
G
M
G
N
V
S
Y
-
P
P
E
F
K
-
T
K
L
D
--
G
-
R
H
--
A
V
Q
L
I
I
D
-
L
I
M
S
H
E
P
--
K
--
T
--
I
-----
T
L
V
P
T
G
G
L
T
N
I
A
M
A
V
R
L
E
P
R
I
V
D
R
V
-----
K
E
-----
V
V
L
M
G
G
G
Y
H
T
-
G
N
A
S
P
V
A
E
F
N
V
F
I
D
P
E
A
A
H
I
V
F
-
N
--
E
S
--
W
N
V
T
M
V
G
L
D
L
T
H
L
A
L
A
T
P
A
V
Q
K
R
V
R
E
V
G
--------------
T
K
P
A
---------------------
A
F
M
L
Q
I
L
D
-----------
F
Y
T
K
V
Y
E
K
E
-
H
D
--
T
Y
G
K
V
-
H
D
P
C
A
V
A
Y
V
I
D
-
P
T
V
M
-
T
-
T
-
E
R
V
P
V
D
I
E
-
L
N
G
A
L
-
T
T
G
M
T
V
A
D
F
R
Y
P
----------
R
P
K
------
N
C
R
--
T
Q
V
A
V
K
L
D
F
D
K
F
W
C
L
V
I
D
A
L
E
R
------------
88
HHSearch
90.14
33%
-68
- C5 -
-
1Q8F
5
RIHB_ECOLI
C:
[3-310]
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
E
I
-
N
V
--
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
-
I
V
A
D
-
N
I
H
G
D
T
G
L
D
G
P
V
F
-
E
P
L
-
T
-
R
Q
A
E
--
S
-
T
H
--
A
V
K
Y
I
I
D
-
T
L
--
M
A
S
D-
G
--
D
--
I
-----
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
-----
R
E
-----
I
V
L
M
G
G
A
Y
G
-
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
--
G
---
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
---
V
I
A
R
M
E
RAG-----------
G
P
A
G
---------------------
E
L
F
S
D
I
M
N
-----------
F
T
L
K
T
Q
F
E
N
-
Y
G
--
L
A
G
G
P
V
H
D
A
T
C
I
G
Y
L
I
N
-
P
D
G
I
-
K
-
T
-
Q
E
M
Y
V
E
V
D
-
V
N
S
-
G
P
C
Y
G
R
T
V
C
D
-
E
L
G
V
-------
L
G
K
P
A
------
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--------------
87
HHSearch
88.64
33%
-67
- C5 -
-
3MKM
-
?
A:
[6-314]
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
E
I
-
N
V
--
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
-
I
V
A
D
-
N
I
H
G
D
T
G
L
D
G
P
V
F
-
E
P
L
-
T
-
R
Q
A
E
--
S
-
T
H
--
A
V
K
Y
I
I
D
-
T
L
--
M
A
S
D-
G
--
D
--
I
-----
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
-----
R
E
-----
I
V
L
M
G
G
A
Y
G
-
T
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
--
G
---
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
---
V
I
A
R
M
E
R
A
G-----------
G
P
A
G
---------------------
E
L
F
S
D
I
M
N
-----------
F
T
L
K
T
Q
F
E
N
-
Y
G
--
L
A
G
G
P
V
H
D
A
T
C
I
G
Y
L
I
N
-
P
D
G
I
-
K
-
T
-
Q
E
M
Y
V
E
V
D
-
V
N
S
-
G
P
C
Y
G
R
T
V
C
D
-
E
L
G
V
-------
L
G
K
P
A
------
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
K
-------------
105
Fugue
87.65
32%
-53
- C5 -
-
1EZR
-
IUNH_LEIMA
A:
[2-313]
P
R
K
I
I
L
D
C
D
P
G
I
D
D
A
V
A
I
F
L
A
H
G
N
P
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
S
L
E
K
V
T
Q
N
A
R
L
V
A
D
V
A
G
I
V
G
V
--
P
V
A
A
G
C
T
K
P
L
V
R
G
V
-
R
N
A
S
-
H
I
H
G
E
T
G
M
G
N
V
S
Y
-
P
P
E
F
K
-
T
K
L
D
--
G
-
R
H
--
A
V
Q
L
I
I
D
-
L
I
--
M
S
H
--
E
PK
T
--
I
-----
T
L
V
P
T
G
G
L
T
N
I
A
M
A
V
R
L
E
P
R
I
V
D
R
V
-----
K
E
-----
V
V
L
M
G
G
G
Y
H
T
-
G
N
A
S
P
V
A
E
F
N
V
F
I
D
P
E
A
A
H
I
V
F
N
E
---
S
--
W
N
V
T
M
V
G
L
D
L
T
H
L
A
L
A
T
P
A
V
Q
K
R
V
R
E
V
G
--------------
T
K
P
A
---------------------
A
F
M
L
Q
I
L
D
-----------
F
Y
T
K
V
Y
E
K
E
-
H
D
---
T
Y
G
K
V
H
D
P
C
A
V
A
Y
V
I
D
-
P
T
V
M
-
T
-
T
-
E
R
V
P
V
D
I
E
-
L
N
G
A
L
-
T
T
G
M
T
V
A
D
-
F
R
Y
P
-------
R
P
K
N
C
------
R
T
Q
V
A
V
K
L
D
F
D
K
F
W
C
L
V
I
D
A
L
E
R
I
G
D
P
------------
10
PsiBlast_PDB
86.90
33%
-54
- C5 -
-
5TSQ
1
?
A:
[2-305]
-
R
K
I
I
L
D
C
D
P
G
I
D
D
A
V
A
I
L
L
A
Y
G
N
P
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
E
K
V
T
R
N
A
Q
L
V
A
D
V
A
G
I
V
G
V
--
P
I
A
A
G
C
C
K
P
L
V
R
K
V
-
R
T
A
P
-
Q
I
H
G
E
T
G
L
G
T
V
S
Y
-
P
S
E
F
K
-
T
K
L
D
--
K
-
R
H
--
A
V
H
L
I
I
E
-
L
I
M
S
H
E
P
--
K
--
S
--
I
-----
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
E
R
V
-----
K
E
-----
V
V
L
M
G
G
S
C
-
C
I
G
N
A
S
P
V
A
E
F
N
I
F
V
D
P
E
A
A
H
I
V
F
-
N
--
E
S
--
W
D
V
T
M
V
G
L
D
L
T
S
Q
A
L
A
T
P
E
V
L
Q
R
V
K
E
V
R
--------------
T
K
P
A
---------------------
D
F
I
L
K
I
L
E
-----------
F
Y
T
K
V
Y
E
T
Q
-
R
N
--
T
Y
A
K
V
-
H
D
P
C
A
V
A
Y
V
I
D
-
P
T
V
M
-
T
-
T
-
N
R
V
P
V
N
I
E
-
L
N
G
E
L
-
T
A
G
M
T
V
T
D
------------
F
R
Y
P
R
------
P
E
Q
C
H
T
Q
V
A
S
K
L
D
F
S
K
Y
W
D
L
V
I
D
A
---------------
97
HHSearch
86.70
31%
-55
- C5 -
-
3G5I
2
RIHA_ECOLI
A:
[3-311]
A
L
P
I
L
L
D
C
D
P
G
H
D
D
A
I
A
I
V
L
A
L
A
S
P
E
L
D
V
K
A
I
T
S
S
A
G
N
Q
T
P
E
K
T
L
R
N
V
L
R
M
L
T
L
L
N
R
T
D
I
--
P
V
A
G
G
A
V
K
P
L
M
R
E
L
-
I
I
A
D
-
N
V
H
G
E
S
G
L
D
G
P
A
L
-
P
E
P
T
--
F
A
P
Q
--
N
-
C
T
--
A
V
E
L
M
A
K
-
T
L
--
R
E
S
A-
E
--
P
--
V
-----
T
I
V
S
T
G
P
Q
T
N
V
A
L
L
L
N
S
H
P
E
L
H
S
K
I
-----
A
R
-----
I
V
I
M
G
G
A
M
G
-
L
G
N
W
T
P
A
A
E
F
N
I
Y
V
D
P
E
A
A
E
I
V
F
Q
S
--
G
---
I
P
V
V
M
A
G
L
D
V
T
H
K
A
Q
I
H
V
E
---
D
T
E
R
F
R
A
IG-----------
N
P
V
S
---------------------
T
I
V
A
E
L
L
D
-----------
F
F
L
E
-----K
W
G
--
F
V
G
A
P
L
H
D
P
C
T
I
A
W
L
L
K
-
P
E
L
F
-
T
-
S
-
V
E
R
W
V
G
V
E
-
T
Q
G
-
K
Y
T
Q
G
M
T
V
V
D
-
Y
Y
Y
L
-------
T
G
N
K
P
------
N
A
T
V
M
V
D
V
D
R
Q
G
F
V
D
L
L
A
D
R
L
K
F
Y
---------------
2
PsiBlast_PDB
86.44
32%
-53
- C5 -
-
1MAS
-
IUNH_CRIFA
A:
[2-308]
-
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
N
P
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
--
P
I
A
A
G
C
D
K
P
L
V
R
K
I
-
M
T
-------
E
S
G
M
G
T
V
A
Y
-
P
A
E
F
K
-
N
K
V
D
--
E
-
R
H
--
A
V
N
L
I
I
D
-
L
V
M
S
H
E
P
--
K
--
T
--
I
-----
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
-----
K
E
-----
V
V
L
M
G
G
G
Y
H
E
-
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
-
N
--
E
S
--
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
L
A
T
P
P
I
L
Q
R
V
K
E
V
D
--------------
T
N
P
A
---------------------
R
F
M
L
E
I
M
D
-----------
Y
Y
T
K
I
Y
Q
S
N
-
R
Y
--
M
A
A
A
A
V
H
D
P
C
A
V
A
Y
V
I
D
-
P
S
V
M
-
T
-
T
-
E
R
V
P
V
D
I
E
-
L
T
G
K
L
-
T
L
G
M
T
V
A
D
------------
F
R
N
P
R
------
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
-------------
24
PsiBlast_CBE
86.42
32%
-51
- C5 -
-
2MAS
1
IUNH_CRIFA
D:
[2-308]
-
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
N
P
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
--
P
I
A
A
G
C
D
K
P
L
V
R
K
I
-
M
T
A
G
-
H
I
H
G
E
S
G
M
G
T
V
A
Y
-
P
A
E
F
K
-
N
K
V
D
--
E
-
R
H
--
A
V
N
L
I
I
D
-
L
V
MS
H
E
P
--
K
--
T
--
I
-----
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
-----
K
E
-----
V
V
L
M
G
G
G
Y
H
E
-
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
-
N
--
E
S
--
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
L
A
T
P
P
I
L
Q
R
V
K
E
V
D
--------------
T
N
P
A
---------------------
R
F
M
L
E
I
M
D
-----------
Y
Y
T
K
I
Y
Q
S
N
-
R
Y
--
M
A
A
A
A
V
H
D
P
C
A
V
A
Y
V
I
D
-
P
S
V
M
-
T
-
T
-
E
R
V
P
V
D
I
E
-
L
T
G
K
L
-
T
L
G
M
T
V
A
D
------------
F
R
N
P
R
------
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
-------------
26
PsiBlast_CBE
86.21
32%
-51
- C5 -
-
2MAS
1
IUNH_CRIFA
B:
[2-308]
-
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
N
P
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
--
P
I
A
A
G
C
D
K
P
L
V
R
K
I
-
M
T
A
G
-
H
I
H
G
E
S
G
M
G
T
V
A
Y
-
P
A
E
F
K
-
N
K
V
D
--
E
-
R
H
--
A
V
N
L
I
I
D
-
L
V
MS
H
E
P
--
K
--
T
--
I
-----
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
-----
K
E
-----
V
V
L
M
G
G
G
Y
H
E
-
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
-
N
--
E
S
--
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
L
A
T
P
P
I
L
Q
R
V
K
E
V
D
--------------
T
N
P
A
---------------------
R
F
M
L
E
I
M
D
-----------
Y
Y
T
K
I
Y
Q
S
N
-
R
Y
--
M
A
A
A
A
V
H
D
P
C
A
V
A
Y
V
I
D
-
P
S
V
M
-
T
-
T
-
E
R
V
P
V
D
I
E
-
L
T
G
K
L
-
T
L
G
M
T
V
A
D
------------
F
R
N
P
R
------
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
-------------
84
HHSearch
86.15
33%
-35
- C5 -
-
4KPO
-
?
A:
[15-329]
N
S
K
I
I
I
D
T
D
P
G
I
D
D
S
V
A
I
L
M
A
F
Q
M
P
G
V
Q
V
L
G
L
T
T
I
F
G
N
C
T
T
E
H
A
T
R
N
A
L
I
L
C
E
K
A
S
H
L
E
V
--
P
V
A
E
G
S
H
E
P
L
K
G
G
K
P
H
V
A
D
-
F
V
H
G
P
D
G
L
G
N
V
D
L
-
P
D
P
T
--
I
K
K
V
--
E
-
E
S
--
A
T
D
F
L
V
D
-
K
V
--
S
R
F
P-
G
--
E
--
V
-----
S
V
L
A
L
G
P
L
T
N
I
A
L
A
I
K
K
D
P
S
F
V
K
N
V
-----
K
K
-----
I
V
V
L
G
G
A
F
F
A
A
G
N
A
T
P
S
A
E
A
N
I
H
S
D
P
E
A
A
D
M
V
F
T
S
--
G
---
A
D
I
Y
V
V
G
L
N
I
T
T
Q
V
S
F
T
D
K
---
D
L
L
E
L
R
N
SQ-----------
G
K
Y
A
---------------------
Q
F
L
C
D
V
C
K
-----------
F
Y
L
D
W
H
T
E
S
-
Y
G
--
A
P
V
I
F
L
H
D
P
V
S
F
A
A
L
V
R
-
P
E
L
F
-
T
-
F
-
K
K
G
V
V
R
V
E
-
T
Q
G
-
I
-
C
V
G
H
T
S
M
D
-
M
L
L
K
KWNSENP
W
T
G
Y
S
------
P
I
S
V
A
W
T
V
D
V
P
K
V
V
A
F
V
K
E
L
V
T
K
----------------
3
PsiBlast_PDB
85.88
32%
-50
- C5 -
-
2MAS
1
IUNH_CRIFA
A:
[2-308]
-
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
N
P
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
--
P
I
A
A
G
C
D
K
P
L
V
R
K
I
-
M
T
A
G
-
H
I
H
G
E
S
G
M
G
T
V
A
Y
-
P
A
E
F
K
-
N
K
V
D
--
E
-
R
H
--
A
V
N
L
I
I
D
-
L
V
M
S
H
E
P
--
K
--
T
--
I
-----
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
-----
K
E
-----
V
V
L
M
G
G
G
Y
H
E
-
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
-
N
--
E
S
--
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
L
A
T
P
P
I
L
Q
R
V
K
E
V
D
--------------
T
N
P
A
---------------------
R
F
M
L
E
I
M
D
-----------
Y
Y
T
K
I
Y
Q
S
N
-
R
Y
--
M
A
A
A
A
V
H
D
P
C
A
V
A
Y
V
I
D
-
P
S
V
M
-
T
-
T
-
E
R
V
P
V
D
I
E
-
L
T
G
K
L
-
T
L
G
M
T
V
A
D
------------
F
R
N
P
R
------
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
-------------
95
HHSearch
85.84
33%
-39
- C5 -
-
3FZ0
1
?
D:
[6-359]
H
R
K
L
I
I
D
T
D
C
G
G
D
D
A
I
A
I
M
L
A
M
T
Q
P
D
V
E
V
I
A
I
T
V
V
W
G
N
V
E
V
N
Q
G
M
E
N
I
G
K
L
L
D
L
Y
D
A
-
D
I
--
P
F
F
R
G
A
E
G
P
L
V
G
E
R
E
T
V
Q
W
-
G
G
F
G
S
D
G
F
G
D
A
G
F
-
P
P
S
Q
R
V
A
L
Q
P
--
K
-
R
H
--
A
A
L
E
I
L
K
-
I
L
--
E
E
A
E
-
P
S
D
D
V
V
Y
-----
Q
L
V
A
L
G
P
L
T
N
V
A
L
A
L
R
L
N
P
D
L
F
S
K
L
GTDTI
P
G
-----
I
V
I
M
N
G
T
S
E
S
K
G
N
S
N
M
A
A
E
F
N
S
H
C
D
P
E
A
G
V
V
V
L
Q
H
--
K
G
WK
C
P
V
Q
L
V
N
W
E
V
T
V
N
S
P
M
T
W
G
F
---
Y
D
K
L
V
NRQ-----------
N
K
W
Q
---------------------
E
F
I
E
K
L
F
Q
-----------
R
L
E
A
F
T
R
--------
V
T
C
V
V
P
D
A
V
A
V
L
V
A
I
R
-
P
E
S
V
-
L
D
S
-
F
L
T
Y
V
T
V
E
-
L
H
G
-
R
E
T
R
G
A
T
C
I
D
-
W
Y
G
T
E
Q
S
M
A
K
-
K
G
R
W
R
------
N
C
N
V
I
T
K
V
D
N
E
M
F
L
K
A
L
R
D
I
V
E
Y
V
---------------
25
PsiBlast_CBE
85.27
32%
-50
- C5 -
-
2MAS
1
IUNH_CRIFA
C:
[2-308]
-
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
N
P
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
--
P
I
A
A
G
C
D
K
P
L
V
R
K
I
-
M
T
A
G
-
H
I
H
G
E
S
G
M
G
T
V
A
Y
-
P
A
E
F
K
-
N
K
V
D
--
E
-
R
H
--
A
V
N
L
I
I
D
-
L
V
MS
H
E
P
--
K
--
T
--
I
-----
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
-----
K
E
-----
V
V
L
M
G
G
G
Y
H
E
-
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
-
N
--
E
S
--
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
L
A
T
P
P
I
L
Q
R
V
K
E
V
D
--------------
T
N
P
A
---------------------
R
F
M
L
E
I
M
D
-----------
Y
Y
T
K
I
Y
Q
S
N
-
R
Y
--
M
A
A
A
A
V
H
D
P
C
A
V
A
Y
V
I
D
-
P
S
V
M
-
T
-
T
-
E
R
V
P
V
D
I
E
-
L
T
G
K
L
-
T
L
G
M
T
V
A
D
------------
F
R
N
P
R
------
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
-------------
96
HHSearch
84.90
33%
-28
- C5 -
-
3FZ0
1
?
B:
[6-359]
H
R
K
L
I
I
D
T
D
C
G
G
D
D
A
I
A
I
M
L
A
M
T
Q
P
D
V
E
V
I
A
I
T
V
V
W
G
N
V
E
V
N
Q
G
M
E
N
I
G
K
L
L
D
L
Y
D
A
-
D
I
--
P
F
F
R
G
A
E
G
P
L
V
G
E
R
E
T
V
Q
W
-
G
G
F
G
S
D
G
F
G
D
A
G
F
-
P
P
S
Q
R
V
A
L
Q
P
--
K
-
R
H
--
A
A
L
E
I
L
K
-
I
L
--
E
E
A
E
-
P
S
D
D
V
V
Y
-----
Q
L
V
A
L
G
P
L
T
N
V
A
L
A
L
R
L
N
P
D
L
F
S
K
L
GTDTI
P
G
-----
I
V
I
M
N
G
T
S
E
S
K
G
N
S
N
M
A
A
E
F
N
S
H
C
D
P
E
A
G
V
V
V
L
Q
H
--
K
G
WK
C
P
V
Q
L
V
N
W
E
V
T
V
N
S
P
M
T
W
G
F
---
Y
D
K
L
V
NRESTPNG
R
V
A
V
NQ
N
K
W
Q
---------------------
E
F
I
E
K
L
F
Q
-----------
R
L
E
A
F
T
R
--------
V
T
C
V
V
P
D
A
V
A
V
L
V
A
I
R
-
P
E
S
V
-
L
D
S
-
F
L
T
Y
V
T
V
E
-
L
H
G
-
R
E
T
R
G
A
T
C
I
D
-
W
Y
G
T
E
Q
S
M
A
K
-
K
G
R
W
R
------
N
C
N
V
I
T
K
V
D
N
E
M
F
L
K
A
L
R
D
I
V
E
Y
V
---------------
83
HHSearch
84.76
33%
-39
- C5 -
-
4KPO
-
?
B:
[15-329]
N
S
K
I
I
I
D
T
D
P
G
I
D
D
S
V
A
I
L
M
A
F
Q
M
P
G
V
Q
V
L
G
L
T
T
I
F
G
N
C
T
T
E
H
A
T
R
N
A
L
I
L
C
E
K
A
S
H
L
E
V
--
P
V
A
E
G
S
H
E
P
L
K
G
G
K
P
H
V
A
D
-
F
V
H
G
P
D
G
L
G
N
V
D
L
-
P
D
P
T
--
I
K
K
V
--
E
-
E
S
--
A
T
D
F
L
V
D
-
K
V
--
S
R
F
P-
G
--
E
--
V
-----
S
V
L
A
L
G
P
L
T
N
I
A
L
A
I
K
K
D
P
S
F
V
K
N
V
-----
K
K
-----
I
V
V
L
G
G
A
F
F
A
A
G
N
A
T
P
S
A
E
A
N
I
H
S
D
P
E
A
A
D
M
V
F
T
S
--
G
---
A
D
I
Y
V
V
G
L
N
I
T
T
Q
V
S
F
T
D
K
---
D
L
L
E
L
R
N
SQ-----------
G
K
Y
A
---------------------
Q
F
L
C
D
V
C
K
-----------
F
Y
L
D
W
H
--------
A
P
V
I
F
L
H
D
P
V
S
F
A
A
L
V
R
-
P
E
L
F
-
T
-
F
-
K
K
G
V
V
R
V
E
-
T
Q
G
-
I
-
C
V
G
H
T
S
M
D
-
M
L
L
K
KWNSENP
W
T
G
Y
S
------
P
I
S
V
A
W
T
V
D
V
P
K
V
V
A
F
V
K
E
L
V
T
K
----------------
104
Fugue
84.27
30%
-47
- C5 -
-
2MAS
1
IUNH_CRIFA
A:
[1-313]
A
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
N
P
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
--
P
I
A
A
G
C
D
K
P
L
V
R
K
I
-
M
T
A
G
-
H
I
H
G
E
S
G
M
G
T
V
A
Y
-
P
A
E
F
K
-
N
K
V
D
--
E
-
R
H
--
A
V
N
L
I
I
D
-
L
V
--
M
S
H
--
E
PK
T
--
I
-----
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
-----
K
E
-----
V
V
L
M
G
G
G
Y
H
E
-
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
---
S
--
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
L
A
T
P
P
I
L
Q
R
V
K
E
V
D
--------------
T
N
P
A
---------------------
R
F
M
L
E
I
M
D
-----------
Y
Y
T
K
I
Y
Q
S
N
-
R
Y
--
M
A
A
A
A
V
H
D
P
C
A
V
A
Y
V
I
D
-
P
S
V
M
-
T
-
T
-
E
R
V
P
V
D
I
E
-
L
T
G
K
L
-
T
L
G
M
T
V
A
D
-
F
R
N
P
-------
R
P
E
H
C
------
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
R
I
G
D
P
------------
54
PsiBlast_CBE
83.80
31%
-36
- C5 -
-
3FZ0
1
?
B:
[7-356]
-
R
K
L
I
I
D
T
D
C
G
G
D
D
A
I
A
I
M
L
A
M
T
Q
P
D
V
E
V
I
A
I
T
V
V
W
G
N
V
E
V
N
Q
G
M
E
N
I
G
K
L
L
D
L
Y
D
-
A
D
I
--
P
F
F
R
G
A
E
G
P
L
V
G
E
R
-
E
T
V
Q
W
G
G
F
G
S
D
G
F
G
D
A
G
F
-
P
P
S
Q
R
-
V
A
L
Q
--
P
K
R
H
--
A
A
L
E
I
L
K
-
I
L
--
E
E
A
--
E
--
P
--
S
DD
V
V
Y
Q
L
V
A
L
G
P
L
T
N
V
A
L
A
L
R
L
N
P
D
L
F
S
K
L
-----
G
T
DTIPG
I
V
I
M
N
G
T
S
E
S
K
G
N
S
N
M
A
A
E
F
N
S
H
C
D
P
E
A
G
V
V
V
L
Q
H
KG
W
K
--
C
P
V
Q
L
V
N
W
E
V
T
---
V
N
S
P
M
T
W
G
F
Y
D
K
L
V
--------------
N
R
E
S
TPNG
R
V
A
V
NQN
K
W
Q
E
F
I
E
K
L
F
Q
R
L
E
A
F
T
R
--------------------------
V
T
C
V
V
P
D
A
V
A
V
L
V
A
I
R
P
E
S
V
L
-
D
-
S
-
F
L
T
Y
V
T
V
E
-
L
H
G
-
R
E
T
R
G
A
T
C
I
D
-
W
Y
G
T
-------
E
Q
S
M
A
K
K
GRWR
N
C
N
V
I
T
K
V
D
N
E
M
F
L
K
A
L
R
D
I
V
------------------
85
HHSearch
83.71
33%
-43
- C5 -
-
3T8J
-
?
A:
[1-310]
M
R
H
F
I
I
D
C
D
T
A
E
D
D
V
L
S
L
Y
L
L
L
K
-
N
N
I
D
V
V
A
V
T
I
V
E
G
N
I
S
Y
E
Q
E
V
K
N
A
L
W
A
L
E
Q
V
N
R
-
E
I
--
P
V
Y
P
G
A
N
K
P
L
L
K
N
Y
-
I
T
V
E
-
K
V
H
G
K
G
G
I
G
D
V
T
V
-
E
P
K
-
R
-
L
K
A
Q
--
E
-
K
H
--
A
A
L
A
I
I
D
-
L
A
--
N
E
Y
A-
G
--
E
--
L
-----
E
F
L
A
I
S
P
L
T
N
L
A
L
A
Y
L
L
D
N
S
I
V
K
K
I
-----
K
K
-----
V
W
V
M
G
G
A
V
F
G
I
G
N
I
T
P
V
A
E
F
N
I
W
V
D
P
D
A
A
K
I
V
F
N
A
--
G
---
F
D
I
T
M
I
P
W
D
V
I
I
N
Y
P
V
T
D
E
---
E
W
N
V
I
K
N
MK-----------
T
R
M
S
---------------------
E
L
Y
V
S
M
Y
L
-----------
H
Y
R
Q
Y
S
S
T
V
-
Q
K
--
I
N
G
H
P
H
P
D
A
I
T
T
A
I
A
I
D
-
G
S
I
A
-
T
-
R
R
E
K
R
F
V
V
I
D
-
N
T
D
-
N
I
T
R
G
M
T
L
V
D
-
R
F
D
A
DTS----
W
S
D
K
P
------
N
A
E
I
V
Y
E
I
N
K
K
S
F
M
E
K
I
Y
D
L
L
N
W
----------------
14
PsiBlast_PDB
83.57
33%
-54
- C5 -
-
3T8J
-
?
A:
[1-308]
M
R
H
F
I
I
D
C
D
T
A
E
D
D
V
L
S
L
Y
L
L
L
K
N
-
N
I
D
V
V
A
V
T
I
V
E
G
N
I
S
Y
E
Q
E
V
K
N
A
L
W
A
L
E
Q
V
N
R
-
E
I
--
P
V
Y
P
G
A
N
K
P
L
L
K
N
Y
-
I
T
V
E
-
K
V
H
G
K
G
G
I
G
D
V
T
V
E
P
K
R
L
K
-
A
Q
E
K
H
A
A
-
L
A
--
I
I
D
L
A
N
E
-
Y
A
--
G
E
---------
L
-----
E
F
L
A
I
S
P
L
T
N
L
A
L
A
Y
L
L
D
N
S
I
V
K
K
I
-----
K
K
-----
V
W
V
M
G
G
A
V
F
G
I
G
N
I
T
P
V
A
E
F
N
I
W
V
D
P
D
A
A
K
I
V
F
-
N
--
A
G
--
F
D
I
T
M
I
P
W
D
V
I
I
N
Y
P
V
T
D
E
E
W
N
V
I
K
N
M
K
--------------
T
R
M
S
---------------------
E
L
Y
V
S
M
Y
L
-----------
H
Y
R
Q
Y
S
S
T
V
-
Q
K
--
I
N
G
H
P
H
P
D
A
I
T
T
A
I
A
I
D
-
G
S
I
A
T
R
-
R
-
E
K
R
F
V
V
I
D
N
T
D
N
-
I
-
T
R
G
M
T
L
V
D
-
R
F
D
A
DTS----
W
S
D
K
P
------
N
A
E
I
V
Y
E
I
N
K
K
S
F
M
E
K
I
Y
D
L
L
------------------
53
PsiBlast_CBE
83.25
31%
-40
- C5 -
-
3FZ0
1
?
C:
[7-356]
-
R
K
L
I
I
D
T
D
C
G
G
D
D
A
I
A
I
M
L
A
M
T
Q
P
D
V
E
V
I
A
I
T
V
V
W
G
N
V
E
V
N
Q
G
M
E
N
I
G
K
L
L
D
L
Y
D
-
A
D
I
--
P
F
F
R
G
A
E
G
P
L
V
G
E
R
-
E
T
V
Q
W
G
G
F
G
S
D
G
F
G
D
A
G
F
-
P
P
S
Q
R
-
V
A
L
Q
--
P
K
R
H
--
A
A
L
E
I
L
K
-
I
L
--
E
E
A
--
E
--
P
--
S
DD
V
V
Y
Q
L
V
A
L
G
P
L
T
N
V
A
L
A
L
R
L
N
P
D
L
F
S
K
L
-----
G
T
DTIPG
I
V
I
M
N
G
T
S
E
S
K
G
N
S
N
M
A
A
E
F
N
S
H
C
D
P
E
A
G
V
V
V
L
Q
H
KG
W
K
--
C
P
V
Q
L
V
N
W
E
V
T
---
V
N
S
P
M
T
W
G
F
Y
D
K
L
V
--------------
N
R
--NQN
K
W
Q
E
F
I
E
K
L
F
--------
Q
R
L
E
A
F
T
R
--------------------------
V
T
C
V
V
P
D
A
V
A
V
L
V
A
I
R
P
E
S
V
L
-
D
-
S
-
F
L
T
Y
V
T
V
E
-
L
H
G
-
R
E
T
R
G
A
T
C
I
D
-
W
Y
G
T
-------
E
Q
S
M
A
K
K
GRWR
N
C
N
V
I
T
K
V
D
N
E
M
F
L
K
A
L
R
D
I
V
------------------
86
HHSearch
81.67
31%
-44
* C5 *
-
5TSQ
1
?
A:
[1-310]
P
R
K
I
I
L
D
C
D
P
G
I
D
D
A
V
A
I
L
L
A
Y
G
N
P
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
E
K
V
T
R
N
A
Q
L
V
A
D
V
A
G
I
V
G
V
--
P
I
A
A
G
C
C
K
P
L
V
R
K
V
-
R
T
A
P
-
Q
I
H
G
E
T
G
L
G
T
V
S
Y
-
P
S
E
F
K
-
T
K
L
D
--
K
-
R
H
--
A
V
H
L
I
I
E
-
L
I
--
M
S
H
EP
K
--
S
--
I
-----
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
E
R
V
-----
K
E
-----
V
V
L
M
G
G
S
C
C
-
I
G
N
A
S
P
V
A
E
F
N
I
F
V
D
P
E
A
A
H
I
V
F
N
E
--
S
---
W
D
V
T
M
V
G
L
D
L
T
S
Q
A
L
A
T
P
E
---
V
L
Q
R
V
K
E
VR-----------
T
K
P
A
---------------------
D
F
I
L
K
I
L
E
-----------
F
Y
T
K
V
Y
E
T
Q
-
R
---
N
T
Y
A
K
V
H
D
P
C
A
V
A
Y
V
I
D
-
P
T
V
M
-
T
-
T
-
N
R
V
P
V
N
I
E
-
L
N
G
-
E
L
T
A
G
M
T
V
T
D
-
F
R
Y
P
-------
R
P
E
Q
C
------
H
T
Q
V
A
S
K
L
D
F
S
K
Y
W
D
L
V
I
D
A
L
Q
R
I
G
--------------
7
PsiBlast_PDB
78.45
33%
-29
- C5 -
-
1Q8F
6
RIHB_ECOLI
A:
[4-299]
-
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
---
K
T
L
I
N
G
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
-
I
V
A
D
-
N
I
H
G
D
T
G
L
D
G
P
V
F
-
E
P
L
T
R
--
Q
A
E
--
S
-
T
H
--
A
V
K
Y
I
I
D
T
L
M
--
A
S
D
--
G
--
D
--
I
-----
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
-----
R
E
-----
I
V
L
M
G
G
A
Y
G
T
-
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
---
G
--
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
I
A
R
M
E
R
A
G
--------------
G
P
A
G
---------------------
E
L
F
S
D
I
M
N
-----------
F
T
L
K
T
Q
F
E
N
-
Y
G
--
L
A
G
G
P
V
H
D
A
T
C
I
G
Y
L
I
N
-
P
D
G
I
-
K
-
T
-
Q
E
M
Y
V
E
V
D
V
N
S
G
-
P
-
C
Y
G
R
T
V
C
D
-
E
L
G
V
-------
L
G
K
P
A
------
N
T
K
V
G
I
T
I
D
T
D
W
F
W
-------------------------
40
PsiBlast_CBE
78.18
33%
-29
- C5 -
-
1Q8F
6
RIHB_ECOLI
D:
[4-299]
-
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
---
K
T
L
I
N
G
L
N
V
C
Q
K
L
E
I
NV
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
-
I
V
A
D
-
N
I
H
G
D
T
G
L
D
G
P
V
F
-
E
P
L
T
R
--
Q
A
E
--
S
-
T
H
--
A
V
K
Y
I
I
D
T
L
M
--
A
S
D
--
G
--
D
--
I
-----
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
-----
R
E
-----
I
V
L
M
G
G
A
Y
G
T
-
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
---
G
--
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
I
A
R
M
E
R
A
G
--------------
G
P
A
G
---------------------
E
L
F
S
D
I
M
N
-----------
F
T
L
K
T
Q
F
E
N
-
Y
G
--
L
A
G
G
P
V
H
D
A
T
C
I
G
Y
L
I
N
-
P
D
G
I
-
K
-
T
-
Q
E
M
Y
V
E
V
D
V
N
S
G
-
P
-
C
Y
G
R
T
V
C
D
-
E
L
G
V
-------
L
G
K
P
A
------
N
T
K
V
G
I
T
I
D
T
D
W
F
W
-------------------------
42
PsiBlast_CBE
77.81
33%
-29
- C5 -
-
1Q8F
5
RIHB_ECOLI
B:
[4-299]
-
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
---
K
T
L
I
N
G
L
N
V
C
Q
K
L
E
I
NV
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
-
I
V
A
D
-
N
I
H
G
D
T
G
L
D
G
P
V
F
-
E
P
L
T
R
--
Q
A
E
--
S
-
T
H
--
A
V
K
Y
I
I
D
T
L
M
--
A
S
D
--
G
--
D
--
I
-----
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
-----
R
E
-----
I
V
L
M
G
G
A
Y
G
T
-
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
---
G
--
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
I
A
R
M
E
R
A
G
--------------
G
P
A
G
---------------------
E
L
F
S
D
I
M
N
-----------
F
T
L
K
T
Q
F
E
N
-
Y
G
--
L
A
G
G
P
V
H
D
A
T
C
I
G
Y
L
I
N
-
P
D
G
I
-
K
-
T
-
Q
E
M
Y
V
E
V
D
V
N
S
G
-
P
-
C
Y
G
R
T
V
C
D
-
E
L
G
V
-------
L
G
K
P
A
------
N
T
K
V
G
I
T
I
D
T
D
W
F
W
-------------------------
41
PsiBlast_CBE
77.79
33%
-27
- C5 -
-
1Q8F
5
RIHB_ECOLI
C:
[4-299]
-
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
---
K
T
L
I
N
G
L
N
V
C
Q
K
L
E
I
NV
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
-
I
V
A
D
-
N
I
H
G
D
T
G
L
D
G
P
V
F
-
E
P
L
T
R
--
Q
A
E
--
S
-
T
H
--
A
V
K
Y
I
I
D
T
L
M
--
A
S
D
--
G
--
D
--
I
-----
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
-----
R
E
-----
I
V
L
M
G
G
A
Y
G
T
-
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
---
G
--
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
I
A
R
M
E
R
A
G
--------------
G
P
A
G
---------------------
E
L
F
S
D
I
M
N
-----------
F
T
L
K
T
Q
F
E
N
-
Y
G
--
L
A
G
G
P
V
H
D
A
T
C
I
G
Y
L
I
N
-
P
D
G
I
-
K
-
T
-
Q
E
M
Y
V
E
V
D
V
N
S
G
-
P
-
C
Y
G
R
T
V
C
D
-
E
L
G
V
-------
L
G
K
P
A
------
N
T
K
V
G
I
T
I
D
T
D
W
F
W
-------------------------
36
PsiBlast_CBE
76.46
33%
-38
- C5 -
-
3MKN
1
?
C:
[7-302]
-
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
---
K
T
L
I
N
G
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
-
I
V
A
D
------
T
G
L
D
G
P
V
F
-
E
P
L
T
R
--
Q
A
E
--
S
-
T
H
--
A
V
K
Y
I
I
D
T
L
M
--
A
S
D
--
G
--
D
--
I
-----
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
-----
R
E
-----
I
V
L
M
G
G
A
Y
G
T
-
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
---
G
--
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
I
A
R
M
E
R
A
G
--------------
G
P
A
G
---------------------
E
L
F
S
D
I
M
N
-----------
F
T
---------------
G
P
V
H
D
A
T
C
I
G
Y
L
I
N
-
P
D
G
I
-
K
-
T
-
Q
E
M
Y
V
E
V
D
V
N
S
G
-
P
-
C
Y
G
R
T
V
C
D
-
E
L
G
V
-------
L
G
K
P
A
------
N
T
K
V
G
I
T
I
D
T
D
W
F
W
-------------------------
48
PsiBlast_CBE
76.01
32%
-48
- C5 -
-
3G5I
1
RIHA_ECOLI
C:
[6-300]
---
I
L
L
D
C
D
P
G
H
D
D
A
I
A
I
V
L
A
L
A
S
P
E
L
D
V
K
A
I
T
S
S
A
G
N
Q
T
P
E
K
T
L
R
N
V
L
R
M
L
T
L
L
N
R
T
D
I
--
P
V
A
G
G
A
V
K
P
L
M
R
E
L
------------
G
L
---
D
G
-
P
A
L
P
E
-
P
T
F
A
--
P
-
Q
N
CT
A
V
E
L
M
A
K
-
T
L
--
R
E
S
--
A
--
E
P
-
V
-----
T
I
V
S
T
G
P
Q
T
N
V
A
L
L
L
N
S
H
P
E
L
H
S
K
I
-----
A
R
-----
I
V
I
M
G
G
A
M
-
G
L
G
N
W
T
P
A
A
E
F
N
I
Y
V
D
P
E
A
A
E
I
V
F
Q
S
--
G
I
--
P
V
V
-
M
A
G
L
D
V
T
H
K
-----------
A
Q
I
H
--------------
V
E
D
T
---------------------
E
R
F
R
A
I
G
N
P
V
S
T
I
V
A
E
L
L
D
F
---------
E
K
WG
F
V
G
A
P
L
H
D
P
C
T
I
A
W
L
L
K
-
P
E
L
F
-
T
-
S
-
V
E
R
W
V
G
V
E
-
T
Q
G
K
Y
-
T
Q
G
M
T
V
V
D
-
Y
Y
Y
L
-------
T
G
N
K
P
------
N
A
T
V
M
V
D
V
D
R
Q
G
F
--------------------------
44
PsiBlast_CBE
75.44
33%
-33
- C5 -
-
3B9X
2
RIHB_ECOLI
C:
[24-319]
-
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
K
H
P
A
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
---
K
T
L
I
N
G
L
N
V
C
Q
K
L
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
-
I
V
A
-------
T
G
L
D
G
P
V
F
-
E
P
L
T
R
--
Q
A
E
--
S
-
T
H
--
A
V
K
Y
I
I
D
T
L
M
--
A
S
D
--
G
--
D
--
I
-----
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
-----
R
E
-----
I
V
L
M
G
G
A
Y
G
T
-
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
---
G
--
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
I
A
R
M
E
R
A
G
--------------
G
P
A
G
---------------------
E
L
F
S
D
--------------------------------
P
V
H
D
A
T
C
I
G
Y
L
I
N
-
P
D
G
I
-
K
-
T
-
Q
E
M
Y
V
E
V
D
V
N
S
G
-
P
-
C
Y
G
R
T
V
C
D
-
E
L
G
V
-------
L
G
K
P
A
------
N
T
K
V
G
I
T
I
D
T
D
W
F
W
-------------------------