@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XX45: (2018-01-02 )
MHIQTKLIHGGISEDPTTGAVSVPIYQTSTYRQDGVGQPKQYEYSRSGNPTRFALEELIADLEGGVRGFAFSSGLSGIHAVFSLFQAGDHILLGDDVYGGTFRLFDKVLTKNGLEYTIIDTSNLDKIEQSIKPNTKALYLETPSNPLLKITDLEKSATLAHQHGLIVIADNTFATPYFQRPLDLGSDIVVHSGTKYLGGHSDVVAGLVTSNHKDLADQIGFYQNAIGAVLGPQDSWLLQRGIKTLSVRMEEHQKNAFVVADFLFSHPAVEKVYYPGLPDHELHGVAKQQMSGFSGMISFTLKNEESAIPFVESLQLFTLAESLGGVESLVEIPSVMTHASIPKEKREEAGIKDGLIRLSVGIEYGQDLINDLAQAFDRIKN
Atome Classification :
(37 SA)
.........10....-....20........30.....--------..--------.40-........50........60........70........80....-.....90........100.......110-.......120.......130........140.......150.......160.-..--.....170.......180.......190.......200.....-..210.....-..220-.--.......230.......240.......250.......260.......270.......280.......290.......300-.--.-.....310.......320.......330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MH
I
Q
T
K
L
IHGGISED-PTTG
A
V
S
V
P
I
Y
QTSTYRQDGV--------GQ--------PK
Q
-
Y
EYSRSGN
P
T
R
F
A
L
E
E
L
I
A
D
L
EGGVR
G
F
AFSSG
L
S
G
I
H
A
-
V
F
S
L
-
F
QAG
D
H
I
L
LGDDVYG
G
T
F
R
L
F
D
K
V
L
TKN-G
L
E
Y
T
I
IDTS
N
L
D
K
I
E
Q
SI-KPNT
K
A
L
Y
L
ETPSN
P
L
L
K
I
TDLEK
S
A
T
LAH-Q-H
G
--
L
I
V
I
ADNTFATPYFQRPLDLGS
D
I
V
V
HSGTKYLGG
H
S
D
V
V
A
G
L
-VTSN
H
K
D
L
A
D
-
Q
I
G
F
--
Y
--
Q
N
A
I
G
A
VLGP
Q
D
S
W
L
L
Q
RG
I
K
T
L
S
V
R
M
E
E
HQKN
A
F
V
V
A
D
F
L
FSHPA
V
E
KVYYPGLP
D
H
E
L
H
G
V
A
K
Q
Q
MSGFS
G
M
I
S
F
T
LK-N--E-ESA
I
P
F
V
E
S
L
Q
L
F
T
L
A
E
S
LG
G
V
E
S
L
V
E
I
P
S
V
M
T
HASI
P
K
E
K
R
E
EAGIKD
G
L
I
R
L
S
V
G
I
E
Y
G
Q
D
L
I
N
D
L
A
Q
A
F
D
R
IKN
1
PsiBlast_PDB
93.37
75%
-95
- C1 -
-
4L0O
2
METB_HELPY
H:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
-
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
----------------------
G
-
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
-
V
F
S
L
-
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
-
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
-
D
-
H
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
-
N
--
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--
26
PsiBlast_CBE
92.79
75%
-94
- C1 -
-
4L0O
2
METB_HELPY
C:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
-
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
-----------
G
-
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
-
V
F
S
L
-
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
-
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
-
D
-
H
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
-
N
--
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
----------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--
22
PsiBlast_CBE
90.99
75%
-96
- C1 -
-
4L0O
2
METB_HELPY
M:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
-
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
-----------
G
-
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
-
V
F
S
L
-
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
-
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
-
D
-
H
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
-
N
--
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--
24
PsiBlast_CBE
90.61
75%
-94
- C1 -
-
4L0O
1
METB_HELPY
G:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
-
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
-------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
-
V
F
S
L
-
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
-
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
-
D
-
H
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
-
N
--
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--
21
PsiBlast_CBE
90.61
75%
-91
- C1 -
-
4L0O
2
METB_HELPY
O:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
-
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
R
--------
H
K
G
-
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
-
V
F
S
L
-
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
-
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
-
D
-
H
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
-
N
--
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--
25
PsiBlast_CBE
90.31
75%
-95
- C1 -
-
4L0O
2
METB_HELPY
E:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
-
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
-------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
-
V
F
S
L
-
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
-
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
-
D
-
H
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
-
N
--
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
-----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--
27
PsiBlast_CBE
90.28
75%
-93
- C1 -
-
4L0O
2
METB_HELPY
A:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
-
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
R
--------
H
K
G
-
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
-
V
F
S
L
-
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
-
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
-
D
-
H
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
-
N
--
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
----------------
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--
140
HHSearch
82.38
75%
-18
- C1 -
-
4L0O
-
METB_HELPY
K:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
-
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
R
--------
H
-
G
-
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
V
F
S
-
L
-
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
-
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
-
D
-
H
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
-
N
--
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--
14
PsiBlast_PDB
79.82
44%
-97
- C1 -
-
1IBJ
2
METC_ARATH
A:
[103-459]
--------------------
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
--------
I
E
--------
N
G
P
-
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
-
V
T
H
L
-
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
-
G
V
V
V
K
R
V
N
T
T
K
L
D
E
V
A
A
A
I
-
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
H
-
A
-
Q
G
--
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
G
V
-
L
A
V
K
G
E
K
L
A
K
-
E
V
Y
F
--
L
--
Q
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
K
G
A
G
S
V
F
S
F
I
T
G
-
S
--
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
-----
139
HHSearch
79.69
75%
-23
- C1 -
-
4L0O
1
METB_HELPY
G:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
-
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
-------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
V
F
S
-
L
-
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
-
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
-
D
-
H
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
-
N
--
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--
43
PsiBlast_CBE
78.47
44%
-94
- C1 -
-
1IBJ
2
METC_ARATH
C:
[103-459]
--------------------
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
--------
I
E
--------
N
G
P
-
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
-
V
T
H
L
-
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
-
G
V
V
V
K
R
V
N
T
T
K
L
D
E
V
A
A
A
I
-
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
H
-
A
-
Q
G
--
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
G
V
-
L
A
V
K
G
E
K
L
A
K
-
E
V
Y
F
--
L
--
Q
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
K
G
A
G
S
V
F
S
F
I
T
G
-
S
--
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
-----
3
PsiBlast_PDB
74.47
52%
-16
- C1 -
-
4IY7
7
?
A:
[15-393]
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
-
P
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
E
--------
H
Q
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
-
V
M
E
L
-
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
D
P
A
A
F
K
A
A
I
-
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
-
K
-
H
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
M
A
F
--
L
--
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
G
F
G
G
I
V
S
I
V
L
K
-
G
--
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-----
30
PsiBlast_CBE
73.99
52%
-13
- C1 -
-
4IY7
5
?
B:
[15-393]
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
-
P
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
E
--------
H
Q
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
-
V
M
E
L
-
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
D
P
A
A
F
K
A
A
I
-
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
-
K
-
H
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
M
A
F
--
L
--
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
G
F
G
G
I
V
S
I
V
L
K
-
G
--
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-----
29
PsiBlast_CBE
73.68
52%
-13
- C1 -
-
4IY7
4
?
C:
[15-393]
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
-
P
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
E
--------
H
Q
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
-
V
M
E
L
-
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
D
P
A
A
F
K
A
A
I
-
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
-
K
-
H
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
M
A
F
--
L
--
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
G
F
G
G
I
V
S
I
V
L
K
-
G
--
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-----
28
PsiBlast_CBE
73.35
52%
-14
- C1 -
-
4IY7
5
?
D:
[15-393]
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
-
P
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
E
--------
H
Q
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
-
V
M
E
L
-
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
D
P
A
A
F
K
A
A
I
-
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
-
K
-
H
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
M
A
F
--
L
--
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
G
F
G
G
I
V
S
I
V
L
K
-
G
--
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-----
4
PsiBlast_PDB
73.28
52%
-15
- C1 -
-
4IYO
7
?
A:
[15-393]
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
-
P
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
E
--------
H
Q
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
-
V
M
E
L
-
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
D
P
A
A
F
K
A
A
I
-
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
-
K
-
H
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
M
A
F
--
L
--
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
G
F
G
G
I
V
S
I
V
L
K
-
G
--
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-----
154
HHSearch
72.97
39%
-46
- C1 -
-
4Q31
2
?
C:
[7-384]
M
R
F
G
T
R
L
V
H
G
G
R
R
P
S
-
A
G
T
G
D
V
V
P
P
I
H
V
S
T
T
Y
E
R
R
A
Q
--------
D
---------
E
P
R
-
Y
F
Y
G
R
G
E
N
P
T
R
E
E
L
E
E
C
L
A
G
L
E
R
A
P
F
A
T
V
F
S
S
G
Q
A
A
A
A
T
-
L
L
S
L
-
V
R
P
G
Q
C
V
V
S
T
D
D
V
Y
A
G
T
D
G
L
F
D
L
-
A
A
R
Q
-
G
V
R
V
R
Y
A
D
L
T
T
P
E
G
I
A
A
A
L
A
E
P
D
L
A
L
V
W
I
E
T
P
T
N
P
L
L
T
V
V
D
V
A
E
V
S
R
R
A
H
-
E
-
R
G
--
A
R
V
V
V
D
N
T
F
A
S
P
V
L
Q
Q
P
L
A
L
G
A
D
V
S
L
Y
S
T
T
K
S
I
A
G
H
A
D
V
L
G
G
A
-
L
V
Y
R
D
A
D
L
H
A
-
A
V
R
A
--
Y
--
R
T
T
A
G
N
V
P
G
A
L
D
C
F
L
V
R
R
G
L
H
T
L
S
L
R
V
H
R
Q
V
A
T
A
R
V
L
V
E
R
L
R
A
S
P
V
V
G
A
V
H
Y
P
G
L
P
E
H
P
Q
H
A
V
V
K
A
Q
M
S
A
P
G
A
I
V
S
F
D
Y
L
-
G
----
G
P
A
E
R
L
L
D
R
F
T
L
F
T
C
G
V
S
L
G
G
V
H
S
L
V
E
C
P
A
L
M
T
H
R
P
L
S
A
E
A
R
A
R
R
G
I
G
E
S
L
I
R
L
S
V
G
I
E
D
P
Q
D
L
A
E
D
L
S
R
A
L
A
G
G
T
-
135
HHSearch
72.45
49%
2
- C1 -
-
3COG
8
CGL_HUMAN
D:
[17-399]
Q
H
F
A
T
Q
A
I
H
V
G
Q
D
P
E
Q
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
G
A
P
--------
G
Q
--------
H
S
G
-
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
T
-
I
T
H
L
-
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
F
-
G
L
K
I
S
F
V
D
C
S
K
I
K
L
L
E
A
A
I
-
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
C
A
H
I
V
H
-
K
-
H
G
D-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
L
-
V
S
V
N
C
E
S
L
H
N
-
R
L
R
F
--
L
--
Q
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
T
G
C
T
G
M
V
T
F
Y
I
K
-
G
--
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
-
50
PsiBlast_CBE
72.09
42%
-1
- C1 -
-
3JWA
6
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
-
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F
A
LE
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
-
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
-
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
-
Q
-
Q
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
K
-
Q
E
F
I
D
-
Q
A
R
F
VG
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
-
G
--
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
---
48
PsiBlast_CBE
71.10
42%
1
- C1 -
-
3JW9
2
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
-
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F
A
LE
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
-
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
-
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
-
Q
-
Q
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
K
-
Q
E
F
I
D
-
Q
A
R
F
VG
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
-
G
--
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
---
49
PsiBlast_CBE
70.74
42%
4
- C1 -
-
3JWB
4
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
-
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F
A
LE
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
-
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
-
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
-
Q
-
Q
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
K
-
Q
E
F
I
D
-
Q
A
R
F
VG
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
-
G
--
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
---
40
PsiBlast_CBE
70.72
47%
9
- C1 -
-
5DX5
2
?
B:
[7-398]
M
G
F
A
T
K
A
I
H
G
G
H
I
G
D
-
K
Q
F
G
S
L
A
T
P
I
Y
Q
T
S
T
F
I
F
D
S
A
EQGGRRFA
G
E
--------
E
S
G
-
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
I
A
A
S
L
W
S
A
-
L
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
N
H
G
L
T
R
Y
-
G
V
E
V
T
F
V
D
V
S
N
L
D
E
V
K
N
A
L
-
K
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
K
I
S
N
M
V
H
-
E
-
S
N
KE
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
Q
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
G
F
-
A
V
G
K
-
E
E
F
I
N
-
Q
V
K
L
--
F
GI
K
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
P
G
L
E
S
F
K
Y
Y
Q
L
A
R
E
Q
M
K
L
P
G
A
M
I
S
F
E
L
K
-
G
GV
E
-
E
G
K
I
-
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
E
E
R
K
A
A
G
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
D
L
I
--
16
PsiBlast_PDB
70.33
42%
-0
- C1 -
-
4OMA
5
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
-
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F
A
LE
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
-
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
-
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
-
Q
-
Q
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
K
-
Q
E
F
I
D
-
Q
A
R
F
VG
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
-
G
--
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
---
18
PsiBlast_PDB
70.10
42%
-1
- C1 -
-
4HF8
5
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
-
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F
A
LE
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
-
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
R
F
V
D
A
A
K
P
E
E
I
R
A
A
M
-
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
-
Q
-
Q
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
K
-
Q
E
F
I
D
-
Q
A
R
F
VG
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
-
G
--
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
---
42
PsiBlast_CBE
69.87
47%
8
- C1 -
-
1E5E
3
?
B:
[10-395]
----
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
QQGGNRFA
G
Q
--------
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
-
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
I
P
G
E
V
K
K
H
M
-
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q
-
E
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
-
I
C
G
K
-
A
D
L
L
Q
-
Q
I
R
M
--
V
GI
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
M
Y
G
S
M
I
T
F
I
L
K
-
S
--
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
--
41
PsiBlast_CBE
69.87
47%
10
- C1 -
-
1E5F
2
?
B:
[10-395]
----
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
QQGGNRFA
G
Q
--------
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
-
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
I
P
G
E
V
K
K
H
M
-
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q
-
E
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
-
I
C
G
K
-
A
D
L
L
Q
-
Q
I
R
M
--
V
GI
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
M
Y
G
S
M
I
T
F
I
L
K
-
S
--
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
--
17
PsiBlast_PDB
69.77
42%
4
- C1 -
-
5M3Z
2
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
-
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F
A
LE
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
-
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
H
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
-
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
-
Q
-
Q
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
K
-
Q
E
F
I
D
-
Q
A
R
F
VG
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
-
G
--
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
---
12
PsiBlast_PDB
69.24
47%
9
- C1 -
-
1E5F
3
?
A:
[10-395]
----
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
--------
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
-
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
I
P
G
E
V
K
K
H
M
-
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q
-
E
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
-
I
C
G
K
-
A
D
L
L
Q
-
Q
I
R
M
--
V
GI
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
M
Y
G
S
M
I
T
F
I
L
K
-
S
--
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
--
10
PsiBlast_PDB
69.12
47%
12
- C1 -
-
5DX5
2
?
A:
[7-398]
M
G
F
A
T
K
A
I
H
G
G
H
I
G
D
-
K
Q
F
G
S
L
A
T
P
I
Y
Q
T
S
T
F
I
F
D
S
A
E
Q
G
G
R
R
F
A
G
E
--------
E
S
G
-
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
I
A
A
S
L
W
S
A
-
L
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
N
H
G
L
T
R
Y
-
G
V
E
V
T
F
V
D
V
S
N
L
D
E
V
K
N
A
L
-
K
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
K
I
S
N
M
V
H
-
E
-
S
N
KE
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
Q
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
G
F
-
A
V
G
K
-
E
E
F
I
N
-
Q
V
K
L
--
F
GI
K
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
P
G
L
E
S
F
K
Y
Y
Q
L
A
R
E
Q
M
K
L
P
G
A
M
I
S
F
E
L
K
-
G
G
V
E
-
E
G
K
I
-
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
E
E
R
K
A
A
G
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
D
L
I
--
11
PsiBlast_PDB
68.71
47%
11
- C1 -
-
1E5E
3
?
A:
[10-395]
----
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
--------
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
-
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
I
P
G
E
V
K
K
H
M
-
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q
-
E
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
-
I
C
G
K
-
A
D
L
L
Q
-
Q
I
R
M
--
V
GI
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
M
Y
G
S
M
I
T
F
I
L
K
-
S
--
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
--
149
HHSearch
68.36
49%
9
- C1 -
-
1E5E
3
?
A:
[6-396]
M
T
P
A
T
A
C
I
H
A
N
P
Q
-
K
-
D
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
--------
Q
Q
G
G
N
R
F
A
GQ
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
-
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
I
P
G
E
V
K
K
H
M
-
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
-
S
Q
E
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
-
I
C
G
K
-
A
D
L
L
Q
-
Q
I
R
M
VG
I
--
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
M
Y
G
S
M
I
T
F
I
L
K
-
S
--
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
-
15
PsiBlast_PDB
68.00
42%
3
- C1 -
-
5E4Z
3
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
-
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F
A
LE
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
-
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
A
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
-
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
-
Q
-
Q
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
K
-
Q
E
F
I
D
-
Q
A
R
F
VG
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
-
G
--
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
---
143
HHSearch
65.79
46%
21
- C1 -
-
5X5H
4
?
A:
[9-386]
-
G
F
S
T
A
S
I
H
A
G
Y
E
P
D
-
D
Y
Y
G
S
I
N
T
P
I
Y
A
S
T
T
F
A
Q
N
A
P
--------
N
E
L-------
R
K
G
-
Y
E
Y
T
R
V
G
N
P
T
I
V
A
L
E
Q
T
V
A
A
L
E
G
A
K
Y
G
R
A
F
S
S
G
M
A
A
T
D
I
L
F
R
I
I
-
L
K
P
G
D
H
I
V
L
G
N
D
A
Y
G
G
T
Y
R
L
I
D
T
V
F
T
A
W
-
G
V
E
Y
T
V
V
D
T
S
V
V
E
E
V
K
A
A
I
-
K
D
N
T
K
L
I
W
V
E
T
P
T
N
P
A
L
G
I
T
D
I
E
A
V
A
K
L
T
E
-
G
-
T
N
--
A
K
L
V
V
D
N
T
F
A
S
P
Y
L
Q
Q
P
L
K
L
G
A
H
A
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
G
L
-
V
V
T
N
D
Q
E
M
D
E
-
E
L
L
F
--
M
--
Q
G
G
I
G
P
I
P
S
V
F
D
A
Y
L
T
A
R
G
L
K
T
L
A
V
R
M
D
R
H
C
D
N
A
E
K
I
A
E
F
L
D
S
R
P
E
V
S
T
V
L
Y
P
G
L
K
N
H
P
G
H
E
V
A
A
K
Q
M
K
R
F
G
G
M
I
S
V
R
F
A
-
G
--
G
E
E
A
A
K
K
F
C
T
S
T
K
L
I
C
L
A
E
S
L
G
G
V
E
S
L
L
E
H
P
A
T
M
T
H
Q
S
A
A
G
---
S
Q
L
E
V
P
R
D
L
V
R
I
S
I
G
I
E
D
I
E
D
L
L
A
D
V
E
Q
A
L
N
N
L
--
56
PsiBlast_CBE
65.71
48%
-12
- C1 -
-
1PFF
18
?
A:
[2-330]
-----------------------------------------------------------------------
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
V
W
T
F
-
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
-
G
V
E
V
D
F
I
D
M
A
V
P
G
N
I
E
K
H
L
-
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
Q
-
K
D
--
I
L
V
I
V
D
N
T
F
A
S
P
I
L
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
-
V
C
S
R
A
D
I
I
A
K
V
K
S
Q
G
--
I
--
K
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
D
H
P
G
H
E
I
A
K
K
Q
M
K
M
F
G
S
M
I
A
F
D
V
D
-
G
--
L
-
E
K
A
K
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V
--
13
PsiBlast_PDB
65.04
46%
22
- C1 -
-
5X5H
4
?
A:
[12-386]
----
T
A
S
I
H
A
G
Y
E
P
D
-
D
Y
Y
G
S
I
N
T
P
I
Y
A
S
T
T
F
A
Q
N
A
P
--------
N
E
--------
L
R
K
G
Y
E
Y
T
R
V
G
N
P
T
I
V
A
L
E
Q
T
V
A
A
L
E
G
A
K
Y
G
R
A
F
S
S
G
M
A
A
T
D
I
-
L
F
R
I
I
L
K
P
G
D
H
I
V
L
G
N
D
A
Y
G
G
T
Y
R
L
I
D
T
V
F
T
A
W
-
G
V
E
Y
T
V
V
D
T
S
V
V
E
E
V
K
A
A
I
-
K
D
N
T
K
L
I
W
V
E
T
P
T
N
P
A
L
G
I
T
D
I
E
A
V
A
K
L
T
E
-
G
-
T
N
--
A
K
L
V
V
D
N
T
F
A
S
P
Y
L
Q
Q
P
L
K
L
G
A
H
A
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
G
L
-
V
V
T
N
D
Q
E
M
D
E
-
E
L
L
F
--
M
--
Q
G
G
I
G
P
I
P
S
V
F
D
A
Y
L
T
A
R
G
L
K
T
L
A
V
R
M
D
R
H
C
D
N
A
E
K
I
A
E
F
L
D
S
R
P
E
V
S
T
V
L
Y
P
G
L
K
N
H
P
G
H
E
V
A
A
K
Q
M
K
R
F
G
G
M
I
S
V
R
F
A
G
G
--
E
-
E
A
A
K
K
F
C
T
S
T
K
L
I
C
L
A
E
S
L
G
G
V
E
S
L
L
E
H
P
A
T
M
T
H
Q
S
A
A
G
S
Q
L
E
---
V
P
R
D
L
V
R
I
S
I
G
I
E
D
I
E
D
L
L
A
D
V
E
Q
A
L
N
N
L
--
20
PsiBlast_PDB
64.20
42%
22
- C1 -
-
3MKJ
1
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
-
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F------------
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
-
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
-
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
-
Q
-
Q
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
K
-
Q
E
F
I
D
-
Q
A
R
F
VG
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
-
G
--
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
---
19
PsiBlast_PDB
63.04
42%
24
- C1 -
-
5K30
6
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
-
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F-----------
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
-
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
-
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
-
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
-
Q
-
Q
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
K
-
Q
E
F
I
D
-
Q
A
R
F
VG
L
--
K
D
I
T
G
G
-
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
-
G
--
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
---