@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XX78: (2018-01-02 )
MKKTFSSLKRLARYIRPYRETFLLVILFTVLTVAFNVALPYVTGLPTTEISRNIANGESINFSYIFKCLIWITVVGIGYCISQLLSGVLMTNVVQSAMHDLRRDIEEKINRLPVSYFDKNQQGNILSRVTNDVDAVSGALQQAFIGIVNAILGITLAAAMMFYIQPMMALISMIMIPTSIWISKRVINASQKYFQSMQNSLGELNGYVQENMTGFSVLKVYGREKETLEGFKKVNHSLKYFGFRAAFISGLMMPLVQLTAYATYIGMAVLGSFYVITGAIVVGQLQAFIQYIWQISQPMGNVTQLSSVLQSASAATKRVFEILDEPEEKENKVDASLPETILGDVTFDHVDFAYDPKKPLIQDLNFEVKAGQTVAVVGPTGAGKTTLINLLMRFYDVDKGAIRIDGIDTKSMSRSDVRSLFGMVLQDAWLYQGTIADNIRFGKLDATDYEVVDAAKTANVDHFIRTMPDGYDMAINSEGDNVSLGQKQLLTIARAVVSDPKILILDEATSSVDTRLEALIQKAMDRVMEGRTSFVIAHRLSTIRDADLILVMDQGQIIEKGTHESLLAQGGFYEKLYNSQFAEEAE
Atome Classification :
(22 SA)
.........10......-----..20........30........40....--------....50.......-.60....---....70....----....-------------.80....---.-------...90........100.......110.......120.......130.---......140.----------...-...---150..---......160.......170.......--180.......190....----...200.......210.......220.......230.-......----.240.....----.--.250-.......260.......270-.........280.......290.......300.......310.......320..-.....330...-.....340.......350..-.--.-------.--.-.360.-----......370.......380.......390.......400.......410.......420.......430.......440-..-.---.---...450.-......460.......470.......480.......490.......500.-.......510.......520.......530.......540.......550.......560.......-570........580....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
K
T
F
S
S
L
K
R
L
A
R
Y
I
R
P
-----
Y
R
E
T
F
L
L
V
I
L
F
T
V
L
T
V
A
F
N
V
ALPYVTGL--------
P
T
T
E
I
S
RNIANGE-SI
N
F
S
Y
I
---
F
K
C
L
I
-
W
I
T
V
----
V
G
I
G
-------------
Y
C
I
S
Q
L
L
---
S
-------
G
V
L
M
T
N
V
V
Q
S
A
M
H
D
L
R
R
D
I
E
E
K
I
N
RL
P
V
S
YFDKNQQ
G
N
I
L
S
R
V
TN
D
V
---
D
A
V
S
G
A
L
Q
Q
A
----------
F
I
G
-
I
V
N
---
A
I
-
L
G
---
I
T
L
A
A
A
M
M
F
Y
I
Q
P
M
M
A
L
I
S
M
I
MIPTS--
I
W
I
S
K
R
V
I
N
A
S
Q
K
Y
F
Q
S
----
M
Q
N
S
L
G
E
L
N
G
Y
V
Q
ENMT
G
F
S
V
L
K
V
YGR
E
K
E
T
L
E
G
F
-
K
-
K
VNH
S
L
----
K
Y
F
G
F
R
A
A
F
----
I
--
S
G
L
M
-
M
P
L
V
Q
L
T
A
Y
A
T
Y
I
G
M
A
V
L
---
G
S
F
Y
V
I
T
G
A
I
V
V
G
Q
L
Q
A
F
I
Q
Y
I
W
Q
ISQPMG
N
V
T
Q
L
S
S
V
L
Q
S
A
S
A
A
T
K
R
V
F
E
I
LD-EP
E
E
KEN-KVD-ASL
P
E
T
I
L
GDVTFDHVDFAY-D--P-------K--K-
P
L
I
Q
D-----L
N
F
E
V
KAG
Q
T
V
A
V
V
GPTGA
G
K
T
T
L
I
N
L
L
M
R
F
YDVDK
G
A
I
R
I
DGIDTKSM
S
R
S
D
V
R
S
L
F
G
M
V
L
Q
D
A
W
L
YQ
G
T
IADN
I
R
FG-KL-D---A---TD
Y
E
V
VD-AAKTA
N
V
D
H
F
I
R
TMPDGY
D
M
A
INSEGDNVS
L
G
Q
K
Q
L
L
T
I
A
R
A
V
VSDP
K
-
I
-
L
I
L
DEAT
S
S
V
D
T
R
L
E
A
L
I
Q
K
A
M
D
R
V
MEGR
T
S
F
V
I
A
H
R
L
STIRDA
D
L
I
L
V
MDQG
Q
I
IEKGT
H
E
S
L
L
AQ-G-
G
F
Y
E
K
L
Y
N
S
Q
FAEEAE
137
HHSearch
83.44
39%
-148
- C1 -
-
3QF4
1
Y288_THEMA
B:
[24-591]
------
T
L
R
R
L
L
G
Y
L
R
P
-----
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
--------
T
I
D
V
V
F
V
P
R
R
-------
F
D
L
L
---
P
R
Y
M
L
-
I
L
G
T
----
I
Y
A
L
-------------
T
S
L
L
F
W
L
---
Q
-------
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
---
D
N
I
N
N
V
L
G
N
S
----------
I
I
Q
-
F
F
S
---
G
I
-
V
T
---
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
--
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
----
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-
D
-
R
V
N
E
S
L
----
R
K
V
G
T
K
A
Q
I
----
F
--
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
E
E
E
K
D
D
-
P
D
A
-
V
-
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
--
K
-------
K
--
K
-
P
V
L
K
D
-----
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
---
T
D
E
E
I
K
E
-
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
-
G
F
Y
Y
E
L
F
T
S
Q
Y
-----
3
PsiBlast_PDB
81.78
38%
-
- C1 -
-
4Q4H
-
Y288_THEMA
B:
[18-592]
L
K
N
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
-----
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
---------------------
K
-
T
I
D
V
V
F
V
PRR
F
D
L
L
P
R
Y
M
L
I
----
L
G
T
I
-------------
Y
A
L
T
S
L
L
F
W
L
Q
-------
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
---
D
N
I
N
N
V
L
G
N
S
----------
I
I
Q
-
F
F
S
---
G
I
-
V
T
---
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
--
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
----
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-
D
-
R
V
N
E
S
L
----
R
K
V
G
T
K
A
Q
I
----
F
--
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
E
E
E
K
D
D
-
P
D
A
-
V
E
L
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
--
K
-------
K
--
K
-
P
V
L
K
D
-----
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
---
T
D
E
E
I
K
E
-
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
-
G
F
Y
Y
E
L
F
T
S
Q
Y
G
----
136
HHSearch
80.38
39%
-
- C1 -
-
4Q4H
-
Y288_THEMA
B:
[24-591]
------
T
L
R
R
L
L
G
Y
L
R
P
-----
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
--------
T
I
D
V
V
F
V
P
R
R
-------
F
D
L
L
---
P
R
Y
M
L
-
I
L
G
T
----
I
Y
A
L
-------------
T
S
L
L
F
W
L
---
Q
-------
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
---
D
N
I
N
N
V
L
G
N
S
----------
I
I
Q
-
F
F
S
---
G
I
-
V
T
---
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
--
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
----
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-
D
-
R
V
N
E
S
L
----
R
K
V
G
T
K
A
Q
I
----
F
--
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
E
E
E
K
D
D
-
P
D
A
-
V
-
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
--
K
-------
K
--
K
-
P
V
L
K
D
-----
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
---
T
D
E
E
I
K
E
-
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
-
G
F
Y
Y
E
L
F
T
S
Q
Y
-----
134
HHSearch
78.01
32%
-
- C1 -
-
4Q4H
-
?
A:
[-2-569]
------
G
S
K
T
L
A
R
Y
L
K
P
-----
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
--------
I
V
D
E
G
I
A
R
G
D
-------
F
S
L
V
---
L
K
T
G
I
-
L
M
L
I
----
V
A
L
I
-------------
G
A
V
G
G
I
G
---
C
-------
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
---
T
Q
L
Q
N
L
V
M
M
L
----------
L
R
I
-
V
V
R
---
A
P
-
L
L
---
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
--
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
----
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
-
R
-
K
A
N
E
S
L
----
R
R
S
I
I
S
A
F
S
----
L
--
I
V
F
A
-
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
---
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
-
E
K
P
A
I
E
E
-
A
D
N
-
A
L
A
L
P
N
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
-
F
--
E
N------
T
--
D
-
P
V
L
S
G
-----
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
E
-
D
---
A
---
T
D
D
E
I
V
E
-
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
-
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
-
C
-
K
P
Y
R
E
I
Y
E
S
Q
F
-----
4
PsiBlast_PDB
73.19
38%
-48
- C1 -
-
4Q4J
-
Y288_THEMA
B:
[18-592]
L
K
N
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
-----
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
---------------------
K
-
T
I
D
V
V
F
V
PRR
F
D
L
L
P
R
Y
M
L
I
----
L
G
T
I
-------------
Y
A
L
T
S
L
L
F
W
L
Q
-------
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
---
D
N
I
N
N
V
L
G
N
S
----------
I
I
Q
-
F
F
S
---
G
I
-
V
T
---
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
--
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
----
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-
D
-
R
V
N
E
S
L
----
R
K
V
G
T
K
A
Q
I
----
F
--
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
E
E
E
K
D
D
-
P
D
A
-
V
E
L
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
--
K
-------
K
--
K
-
P
V
L
K
D
-----
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
---
T
D
E
E
I
K
E
-
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
-
G
F
Y
Y
E
L
F
T
S
Q
Y
G
----
8
PsiBlast_PDB
72.64
32%
-58
- C1 -
-
5MKK
-
?
A:
[16-598]
---------
R
I
L
R
Y
V
W
P
-----
Y
R
L
Q
V
V
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
-----------
K
W
A
I
D
L
A
L
V
P
T
E
-
P
R
P
L
A
E
R
---
F
H
L
L
L
-
W
I
S
L
G
F
L
A
V
R
A
V
-------------
H
F
A
A
T
Y
G
---
E
-------
T
Y
L
I
Q
W
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
N
P
V
G
R
L
M
T
R
V
T
S
D
V
---
D
A
I
N
Q
F
I
T
G
G
----------
L
V
G
-
V
I
A
---
D
L
-
F
T
---
L
V
G
L
L
G
F
M
L
F
L
S
P
K
L
T
L
V
V
L
L
V
A
P
V
L
--
L
A
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
E
----
M
R
L
R
L
A
R
V
N
A
A
L
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
-
D
-
R
L
N
R
D
L
--------
F
R
A
W
V
E
I
I
R
W
--
F
A
L
F
-
F
P
V
V
G
F
L
G
D
F
A
V
A
S
L
V
Y
Y
---
G
G
G
E
V
V
R
G
A
V
S
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
Q
P
L
Q
D
L
S
D
K
F
N
L
F
Q
G
A
M
A
S
A
E
R
I
F
G
V
L
D
-
T
E
E
E
L
K
D
-
P
E
D
-
P
T
P
I
R
G
F
R
G
E
V
E
F
R
D
V
W
L
A
Y
-
T
--
P
-------
K
GV
E
-
P
T
E
K
D
WVLKG
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
D
P
Q
R
G
C
V
F
L
D
G
V
D
V
R
R
Y
R
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
L
F
S
G
T
V
L
D
N
L
R
L
F
-
D
P
-
S
---
V
---
P
P
E
R
V
E
E
-
V
A
R
F
L
G
A
H
E
F
I
L
R
L
P
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
-
I
L
L
I
L
D
E
A
T
A
S
V
D
S
E
T
E
K
R
L
Q
E
A
L
Y
K
A
M
E
G
R
T
S
L
I
I
A
H
R
L
S
T
I
R
H
V
D
R
I
L
V
F
R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
A
K
-
G
-
G
Y
Y
A
A
L
Y
R
L
Q
F
Q
E
---
9
PsiBlast_PDB
72.50
32%
-
- C1 -
-
3B5X
-
MSBA_VIBCH
A:
[10-581]
----
W
Q
T
F
K
R
L
W
T
Y
I
R
L
-----
Y
K
A
G
L
V
V
S
T
I
A
L
V
I
N
A
A
---
A
D
T
Y
M
I
S
L
--------
L
K
P
L
L
D
E
G
F
G
N
A
E
-
S
-
N
F
L
R
I
L
P
-
F
M
I
L
G
-
L
M
F
V
----
R
G
L
S
G
F
A
S
S
--------
Y
C
L
S
W
V
S
---
G
-------
N
V
V
M
---------
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
---
E
Q
V
A
G
A
T
S
R
A
----------
L
V
S
-
I
V
R
---
E
G
-
A
S
---
I
I
G
L
L
T
L
M
F
W
N
S
W
Q
L
S
L
V
L
I
V
V
A
P
V
V
--
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
----
M
Q
T
A
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
-
D
-
K
V
S
N
S
M
----
R
Q
Q
T
M
K
L
V
S
----
A
--
Q
S
I
A
-
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
---
A
S
V
D
S
I
R
A
E
L
T
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
M
D
-
L
E
T
E
R
D
N
G
K
Y
E
-
A
---
E
R
V
N
G
E
V
D
V
K
D
V
T
F
T
Y
-
Q
--
G
-------
K
E-
K
-
P
A
L
S
H
-----
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
A
E
G
-
E
---
Y
---
T
R
E
Q
I
E
Q
-
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
-
V
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
-
D
-
G
A
Y
A
Q
L
H
R
I
Q
F
G
----
1
PsiBlast_PDB
72.22
38%
-43
- C1 -
-
3QF4
1
Y288_THEMA
B:
[18-592]
L
K
N
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
-----
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
---------------------
K
-
T
I
D
V
V
F
V
PRR
F
D
L
L
P
R
Y
M
L
I
----
L
G
T
I
-------------
Y
A
L
T
S
L
L
F
W
L
Q
-------
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
---
D
N
I
N
N
V
L
G
N
S
----------
I
I
Q
-
F
F
S
---
G
I
-
V
T
---
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
--
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
----
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-
D
-
R
V
N
E
S
L
----
R
K
V
G
T
K
A
Q
I
----
F
--
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
E
E
E
K
D
D
-
P
D
A
-
V
E
L
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
--
K
-------
K
--
K
-
P
V
L
K
D
-----
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
---
T
D
E
E
I
K
E
-
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
-
G
F
Y
Y
E
L
F
T
S
Q
Y
G
----
2
PsiBlast_PDB
69.94
38%
-45
- C1 -
-
4Q4A
1
Y288_THEMA
B:
[18-592]
L
K
N
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
-----
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
---------------------
K
-
T
I
D
V
V
F
V
PRR
F
D
L
L
P
R
Y
M
L
I
----
L
G
T
I
-------------
Y
A
L
T
S
L
L
F
W
L
Q
-------
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
---
D
N
I
N
N
V
L
G
N
S
----------
I
I
Q
-
F
F
S
---
G
I
-
V
T
---
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
--
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
----
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-
D
-
R
V
N
E
S
L
----
R
K
V
G
T
K
A
Q
I
----
F
--
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
E
E
E
K
D
D
-
P
D
A
-
V
E
L
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
--
K
-------
K
--
K
-
P
V
L
K
D
-----
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
---
T
D
E
E
I
K
E
-
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
-
G
F
Y
Y
E
L
F
T
S
Q
Y
G
----
135
HHSearch
69.59
31%
-42
- C1 -
-
5MKK
-
?
A:
[12-592]
-----
A
L
F
A
R
I
L
R
Y
V
W
P
-----
Y
R
L
Q
V
V
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
W
--------
A
I
D
L
A
L
V
P
T
E
P
R
P
L
A
E
R
F
H
L
L
---
L
W
I
S
L
-
G
F
L
A
----
V
R
A
V
-------------
H
F
A
A
T
Y
G
---
E
-------
T
Y
L
I
Q
W
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
N
P
V
G
R
L
M
T
R
V
T
S
D
V
---
D
A
I
N
Q
F
I
T
G
G
----------
L
V
G
-
V
I
A
---
D
L
-
F
T
---
L
V
G
L
L
G
F
M
L
F
L
S
P
K
L
T
L
V
V
L
L
V
A
P
V
L
--
L
A
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
E
----
M
R
L
R
L
A
R
V
N
A
A
L
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
-
D
-
R
L
N
R
D
L
----
F
R
A
W
V
E
I
I
R
----
W
--
F
A
L
F
-
F
P
V
V
G
F
L
G
D
F
A
V
A
S
L
V
Y
Y
---
G
G
G
E
V
V
R
G
A
V
S
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
Q
P
L
Q
D
L
S
D
K
F
N
L
F
Q
G
A
M
A
S
A
E
R
I
F
G
V
L
D
-
T
E
E
E
L
K
D
-
P
E
D
-
P
T
P
I
R
G
F
R
G
E
V
E
F
R
D
V
W
L
A
Y
-
T
--
P
KGVEPTE
K
--
D
-
W
V
L
K
G
-----
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
D
P
Q
R
G
C
V
F
L
D
G
V
D
V
R
R
Y
R
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
L
F
S
G
T
V
L
D
N
L
R
L
F
-
D
P
-
S
---
V
---
P
P
E
R
V
E
E
-
V
A
R
F
L
G
A
H
E
F
I
L
R
L
P
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
I
L
-
L
I
L
D
E
A
T
A
S
V
D
S
E
T
E
K
R
L
Q
E
A
L
Y
K
A
M
E
G
R
T
S
L
I
I
A
H
R
L
S
T
I
R
H
V
D
R
I
L
V
F
R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
A
K
-
G
-
G
Y
Y
A
A
L
Y
---------
20
PsiBlast_PDB
68.59
30%
-
* C1 *
-
4RY2
-
?
A:
[157-718]
---------
K
F
A
G
F
L
K
P
-----
L
K
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
--------
L
F
D
D
L
I
K
-----------------
F
E
K
L
N
-
D
L
H
I
----
I
S
A
G
-------------
F
A
V
I
F
L
L
---
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
----------
M
I
D
-
T
I
M
---
A
V
-
I
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
-----
F
N
K
P
I
Q
N
A
N
R
---
Q
I
----
M
E
D
N
-
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
-
R
D
K
I
E
T
V
M
----
K
-----
S
S
F
----
K
--
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
-
L
A
T
E
K
E
L
-------------
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
--
L
-------
R
--
K
-
P
V
L
K
N
-----
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
-
N
E
-
N
---
V
---
D
M
D
E
I
I
K
-
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
-
I
-
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
-
K
-
G
C
Y
F
K
M
W
---------
127
HHSearch
68.32
31%
-
- C1 -
-
3B5X
-
MSBA_VIBCH
A:
[10-575]
----
W
Q
T
F
K
R
L
W
T
Y
I
R
L
-----
Y
K
A
G
L
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
--------
L
L
D
E
G
F
G
N
A
E
-------
S
N
F
L
---
R
I
L
P
F
-
M
I
L
G
----
L
M
F
V
-------------
R
G
L
S
G
F
A
---
S
-------
S
Y
C
L
S
W
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
---
E
Q
V
A
G
A
T
S
R
A
----------
L
V
S
-
I
V
R
---
E
G
-
A
S
---
I
I
G
L
L
T
L
M
F
W
N
S
W
Q
L
S
L
V
L
I
V
V
A
P
V
V
--
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
----
M
Q
T
A
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
-
D
-
K
V
S
N
S
M
----
R
Q
Q
T
M
K
L
V
S
----
A
--
Q
S
I
A
-
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
---
A
S
V
D
S
I
R
A
E
L
T
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
M
D
-
L
E
T
E
R
D
N
-
G
K
Y
---
E
A
E
R
V
N
G
E
V
D
V
K
D
V
T
F
T
Y
-
Q
--
G
K------
E
--
K
-
P
A
L
S
H
-----
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
-
A
E
G
E
---
Y
---
T
R
E
Q
I
E
Q
-
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
-
V
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
-
D
-
G
A
Y
A
Q
L
----------
24
PsiBlast_CBE
67.06
32%
-24
- C1 -
-
3QF4
1
?
A:
[12-579]
--------
K
T
L
A
R
Y
L
K
P
-----
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
--------
I
V
D
E
---
G
I
A
R
G
D
----
F
S
L
V
---
L
K
T
G
I
-
L
M
L
I
----
V
A
L
I
-------------
G
A
V
G
G
I
G
---
C
-------
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
---
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
---
A
V
S
I
N
---
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
----------
V
W
L
T
K
K
----
G
N
P
L
F
R
K
----
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
-
R
-
K
A
N
E
S
L
----
R
R
S
I
I
S
A
F
S
----
L
--
I
V
F
A
-
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
---
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
-
E
K
P
A
I
E
E
-
A
D
N
-
A
L
A
L
P
N
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
--
N
-------
T
--
D
-
P
V
L
S
G
-----
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
E
-
D
---
A
---
T
D
D
E
I
V
E
-
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
-
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
-
C
-
K
P
Y
R
E
I
Y
E
S
Q
F
-----
23
PsiBlast_CBE
66.52
32%
-24
- C1 -
-
4Q4A
1
?
A:
[12-579]
--------
K
T
L
A
R
Y
L
K
P
-----
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
--------
I
V
D
E
---
G
I
A
R
G
D
----
F
S
L
V
---
L
K
T
G
I
-
L
M
L
I
----
V
A
L
I
-------------
G
A
V
G
G
I
G
---
C
-------
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
---
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
---
A
V
S
I
N
---
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
----------
V
W
L
T
K
K
----
G
N
P
L
F
R
K
----
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
-
R
-
K
A
N
E
S
L
----
R
R
S
I
I
S
A
F
S
----
L
--
I
V
F
A
-
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
---
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
-
E
K
P
A
I
E
E
-
A
D
N
-
A
L
A
L
P
N
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
--
N
-------
T
--
D
-
P
V
L
S
G
-----
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
E
-
D
---
A
---
T
D
D
E
I
V
E
-
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
-
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
-
C
-
K
P
Y
R
E
I
Y
E
S
Q
F
-----
133
HHSearch
66.28
28%
-47
- C1 -
-
4MRP
3
ATM1_NOVAD
A:
[17-601]
----
W
Q
T
L
K
R
F
L
P
Y
L
W
P
ADN
A
V
L
R
R
R
V
V
G
A
I
L
M
V
L
L
G
K
A
T
T
L
A
L
P
F
A
Y
K
K
--------
A
V
D
A
M
T
L
G
G
G
A
Q
---
P
A
L
T
V
A
---
L
A
F
V
L
-
A
Y
A
L
----
G
R
F
S
-------------
G
V
L
F
D
N
L
---
R
-------
N
I
V
F
E
R
V
G
Q
D
A
T
R
H
L
A
E
N
V
F
A
R
L
H
K
L
S
L
R
F
H
L
A
R
R
T
G
E
V
T
K
V
I
E
R
G
T
---
K
S
I
D
T
M
L
Y
F
L
----------
L
F
N
-
I
A
P
---
T
V
-
I
E
---
L
T
A
V
I
V
-
I
F
W
L
N
F
G
L
G
L
V
T
A
T
I
L
A
V
I
A
Y
V
W
T
T
R
T
I
T
E
W
R
T
H
L
R
E
K
----
M
N
R
L
D
G
Q
A
L
A
R
A
V
D
S
L
L
N
Y
E
T
V
K
Y
F
G
A
E
S
R
E
E
A
R
Y
-
A
-
S
A
A
R
A
Y
----
A
D
A
A
V
K
S
E
N
----
S
--
L
G
L
L
-
N
I
A
Q
A
L
I
V
N
L
L
M
A
G
A
M
A
W
---
T
V
Y
G
W
S
Q
G
K
L
T
V
G
D
L
V
F
V
N
T
Y
L
T
Q
L
F
R
P
L
D
M
L
G
M
V
Y
R
T
I
R
Q
G
L
I
D
M
A
E
M
F
R
L
I
D
-
T
H
I
E
V
A
D
-
V
P
N
-
A
P
A
L
V
V
N
R
P
S
V
T
F
D
N
V
V
F
G
Y
-
D
--
R
-------
D
--
R
-
E
I
L
H
G
-----
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
E
G
R
I
L
I
D
G
Q
D
I
A
H
V
T
Q
T
S
L
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
N
D
T
I
G
Y
N
I
A
Y
G
-
R
D
-
G
---
A
---
S
R
A
E
V
D
A
-
A
A
K
G
A
A
I
A
D
F
I
A
R
L
P
Q
G
Y
D
T
E
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
-
I
-
L
L
F
D
E
A
T
S
A
L
D
T
R
T
E
Q
D
I
L
S
T
M
R
A
V
A
S
H
R
T
T
I
S
I
A
H
R
L
S
T
I
A
D
S
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
L
D
L
L
R
R
-
D
-
G
L
Y
A
E
M
W
A
R
Q
A
A
E
S
A
-
123
HHSearch
63.86
28%
-39
- C1 -
-
4AYX
6
ABCBA_HUMAN
A:
[4-574]
----
L
P
E
A
R
K
L
L
G
L
A
Y
P
-----
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
--------
I
I
D
V
I
Y
T
N
P
T
V
D
----
Y
S
D
N
L
---
T
R
L
C
L
-
G
L
S
A
----
V
F
L
C
-------------
G
A
A
A
N
A
I
---
R
-------
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
---
A
L
L
G
R
S
V
T
E
N
----------
L
S
D
-
G
L
R
---
A
G
-
A
Q
---
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
--
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
----
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
-
A
-
S
K
V
D
H
V
----
M
Q
L
A
R
K
E
A
F
----
A
--
R
A
G
F
-
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
---
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
-
R
E
P
K
L
P
F
-
N
E
G
V
I
L
N
E
K
S
F
Q
G
A
L
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F
K
N
V
H
F
A
Y
-
P
--
A
-------
R
PE
V
-
P
I
F
Q
D
-----
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
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G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
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S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
PSS
V
---
T
A
E
E
I
Q
R
-
V
A
E
V
A
N
A
V
A
F
I
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N
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F
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T
V
V
G
E
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G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
-
L
L
L
D
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A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
-
P
N
G
---------------
132
HHSearch
63.50
28%
-45
- C1 -
-
4MRS
7
ATM1_NOVAD
B:
[17-601]
----
W
Q
T
L
K
R
F
L
P
Y
L
W
P
ADN
A
V
L
R
R
R
V
V
G
A
I
L
M
V
L
L
G
K
A
T
T
L
A
L
P
F
A
Y
K
K
--------
A
V
D
A
M
T
L
G
G
G
A
Q
---
P
A
L
T
V
A
---
L
A
F
V
L
-
A
Y
A
L
----
G
R
F
S
-------------
G
V
L
F
D
N
L
---
R
-------
N
I
V
F
E
R
V
G
Q
D
A
T
R
H
L
A
E
N
V
F
A
R
L
H
K
L
S
L
R
F
H
L
A
R
R
T
G
E
V
T
K
V
I
E
R
G
T
---
K
S
I
D
T
M
L
Y
F
L
----------
L
F
N
-
I
A
P
---
T
V
-
I
E
---
L
T
A
V
I
V
-
I
F
W
L
N
F
G
L
G
L
V
T
A
T
I
L
A
V
I
A
Y
V
W
T
T
R
T
I
T
E
W
R
T
H
L
R
E
K
----
M
N
R
L
D
G
Q
A
L
A
R
A
V
D
S
L
L
N
Y
E
T
V
K
Y
F
G
A
E
S
R
E
E
A
R
Y
-
A
-
S
A
A
R
A
Y
----
A
D
A
A
V
K
S
E
N
----
S
--
L
G
L
L
-
N
I
A
Q
A
L
I
V
N
L
L
M
A
G
A
M
A
W
---
T
V
Y
G
W
S
Q
G
K
L
T
V
G
D
L
V
F
V
N
T
Y
L
T
Q
L
F
R
P
L
D
M
L
G
M
V
Y
R
T
I
R
Q
G
L
I
D
M
A
E
M
F
R
L
I
D
-
T
H
I
E
V
A
D
-
V
P
N
-
A
P
A
L
V
V
N
R
P
S
V
T
F
D
N
V
V
F
G
Y
-
D
--
R
-------
D
--
R
-
E
I
L
H
G
-----
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
E
G
R
I
L
I
D
G
Q
D
I
A
H
V
T
Q
T
S
L
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
N
D
T
I
G
Y
N
I
A
Y
G
-
R
D
-
G
---
A
---
S
R
A
E
V
D
A
-
A
A
K
G
A
A
I
A
D
F
I
A
R
L
P
Q
G
Y
D
T
E
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
-
I
-
L
L
F
D
E
A
T
S
A
L
D
T
R
T
E
Q
D
I
L
S
T
M
R
A
V
A
S
H
R
T
T
I
S
I
A
H
R
L
S
T
I
A
D
S
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
L
D
L
L
R
R
-
D
-
G
L
Y
A
E
M
W
A
R
Q
A
A
E
S
A
-
29
PsiBlast_CBE
62.81
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
C:
[63-581]
------------------------------------------------------------------------------------
V
L
L
-
W
M
P
L
----
V
V
I
G
LMILRGITSYISS
Y
C
I
S
W
V
S
---
G
-------
K
V
V
M
T
---------
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
---
E
Q
V
A
S
S
S
S
G
A
----------
L
I
T
-
V
V
R
EGA
S
I
-
I
G
---
L
F
I
---
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
---
V
S
I
A
I
R
V
V
S
---
K
R
F
R
S
ISKN
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
-
D
-
K
V
S
N
K
M
----
R
L
Q
G
M
K
M
V
S
----
A
--
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
---
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
E
Q
E
K
D
E
---
G
-
K
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
--
G
-------
R
--
E
V
P
A
L
R
N
-----
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
----
12
PsiBlast_PDB
62.81
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
A:
[63-581]
------------------------------------------------------------------------------------
V
L
L
-
W
M
P
L
----
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
---
G
-------
K
V
V
M
T
---------
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
---
E
Q
V
A
S
S
S
S
G
A
----------
L
I
T
-
V
V
R
EG
A
S
I
-
I
G
---
L
F
I
---
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
---
V
S
I
A
I
R
V
V
S
---
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
-
D
-
K
V
S
N
K
M
----
R
L
Q
G
M
K
M
V
S
----
A
--
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
---
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
E
Q
E
K
D
E
---
G
-
K
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
--
G
-------
R
--
E
V
P
A
L
R
N
-----
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
----
30
PsiBlast_CBE
62.78
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
B:
[63-581]
------------------------------------------------------------------------------------
V
L
L
-
W
M
P
L
----
V
V
I
G
LMILRGITSYISS
Y
C
I
S
W
V
S
---
G
-------
K
V
V
M
T
---------
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
---
E
Q
V
A
S
S
S
S
G
A
----------
L
I
T
-
V
V
R
EGA
S
I
-
I
G
---
L
F
I
---
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
---
V
S
I
A
I
R
V
V
S
---
K
R
F
R
S
ISKN
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
-
D
-
K
V
S
N
K
M
----
R
L
Q
G
M
K
M
V
S
----
A
--
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
---
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
E
Q
E
K
D
E
---
G
-
K
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
--
G
-------
R
--
E
V
P
A
L
R
N
-----
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
----
17
PsiBlast_PDB
60.61
31%
-16
- C1 -
-
4AYX
6
ABCBA_HUMAN
A:
[16-574]
----------------
P
-----
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
Y
S
D
N
L
T
R
-
L
-
C
L
G
L
S
A
V
---
F
L
C
G
A
-
A
A
N
A
----
I
R
V
---------------------------------
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
---
A
L
L
G
R
S
V
T
E
N
----------
L
S
D
-
G
L
R
---
A
G
-
A
Q
---
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
--
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
----
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
-
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
----
F
G
A
T
G
L
S
-
G
N
L
I
V
L
S
V
L
--
Y
K
G
G
L
L
M
---
G
S
A
H
-----
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
-
E
G
V
-
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
AR
P
-------
E
--
V
-
P
I
F
Q
D
-----
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
SSV
T
A
E
E
I
Q
R
-
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
-
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
-
G
---------------
48
PsiBlast_CBE
47.50
42%
-130
- C1 -
-
5DGX
1
A:
[17-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
V
T
I
K
D
L
S
F
A
F
-
G
--
E
-------
H
--
K
-
V
L
-
S
G
-----
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
E
G
E
I
L
L
D
G
V
D
T
R
E
L
T
L
E
N
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
D
D
T
V
Y
N
N
I
A
F
G
----
E
---
V
---
S
E
E
E
V
I
D
-
A
L
K
R
A
N
A
Y
E
F
V
Q
E
L
S
D
G
I
N
T
N
I
G
N
N
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
-
V
-
L
I
F
D
E
----------------
L
E
S
L
T
K
S
C
T
T
I
V
I
A
H
R
L
S
T
V
E
N
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
-
G
-
G
L
Y
T
R
L
Y
Q
S
-------