@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XX90: (2018-01-02 )
MIERDTSRHFELVSKYQPAGDQPEAINQLVDGVVGGKKAQILLGATGTGKTYTISNLIEKVNKPTLIIAHNKTLAGQLYGEFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVIASVSCIFGLGSPFEYQKQVVSIRQGAELDRNQLIRDLVSIQFERNDIDFQRGRFRVRGDVVEIFPASRDERALRVEFFGDEVERIREVNALTGEVLGETEHVAIFPATHFVTNDEHMEHAVANIKAELEQRLTVLRNENKLLEAQRLEQRTNYDIEMMLEMGYTSGIENYSRHMDGRKEGEPPYTLLDFFPEDFLIVADESHVTMPQIRGMYNGDRARKQMLVDYGFRLPSALDNRPLRLEEFEKHVNQIIYVSATPGPYEHEQTDTVIQQIIRPTGLLDPVIEVRPIMGQIDDLVGEINERVEKDQRVFVTTLTKKMAEDLTDYFKELGIKVKYLHSDIKTLERTEIIRDLRLGEFDVLVGINLLREGLDVPEVSLVAILDADKEGFLRSERSLVQTIGRAARNEEGKVIMYADKVTDSMRLAMDETSRRRTIQQKYNEEHGIVPKTIIKEIRDLISITKESEDDTKEAVQVSYEEMTKEEKDTLLMKLEKEMKDAAKALDFETAANVRDMILELKASK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60...--.....70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230........240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410........420.......430.......440.......450........460.......470.......480.......490.......500.......510.......520.......530.......540......-.-550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MIERD
T
S
R
H
F
E
L
V
S
KYQPAGD
Q
P
E
A
I
N
Q
L
V
D
G
VVGG
K
K
A
Q
I
L
L
GATGTG
K
T
Y
T
I
S
N
L
I
E
KVNK
P
--
T
L
I
I
AHNK
T
L
A
G
Q
L
Y
G
E
F
K
E
FFPN
N
A
V
E
Y
F
V
S
Y
Y
D
Y
YQPEAYVPSSD
T
Y
IEKDSSV
N
D
E
I
D
K
L
R
H
S
A
T
S
S
L
LERN
D
V
I
V
I
A
S
V
S
C
I
FGLG
S
P
F
E
Y
Q
K
Q
V
V
S
I
R
QGAEL
D
R
N
Q
L
I
R
D
L
V
S
I
Q
F
ERNDIDFQR
G
R
F
R
V
RG
D
V
V
E
I
FPASRDE
R
A
L
R
V
E
FF
G
D
E
V
E
R
I
R
-
E
V
N
A
L
T
G
E
VLGETE
H
V
A
I
F
PA
T
H
FVT
N
D
E
H
M
E
H
A
V
A
N
I
K
A
E
L
E
Q
R
L
T
V
L
RNE
N
K
L
L
E
A
Q
R
L
E
Q
RTNY
D
I
E
M
M
L
EMGYTS
G
I
E
N
Y
S
R
HMDGRKEGEPPY
T
L
L
DFFPE
D
F
L
I
V
ADESHVT
M
P
Q
I
R
GMYN
G
D
R
A
R
K
Q
M
L
V
D
YGFRL
P
S
ALDNRPL
R
L
E
E
F
E
K
H
VN
Q
I
I
Y
V
SATPGPYEH
E
Q
T
D
T
-
V
I
Q
Q
I
I
RPTGLLD
P
V
I
E
V
R
P
I
M
G
Q
I
D
D
L
V
G
E
I
N
E
R
V
EKDQ-R
V
F
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
F
K
ELG
I
K
V
K
Y
L
H
S
D
I
K
T
L
E
R
T
E
I
I
R
D
LRLG
E
F
D
V
L
V
G
I
N
L
L
REGLDVP
E
V
S
L
V
A
I
LDADKEG
F
L
R
S
E
R
S
L
V
Q
T
I
G
R
A
AR-N-EEG
K
V
I
M
Y
ADKVTD
S
M
R
L
AM
D
E
T
S
R
R
R
T
I
Q
Q
K
YNEEHGIV
P
K
T
I
I
K
E
I
R
D
L
I
S
I
TKESED
D
T
K
E
A
V
Q
V
S
Y
E
E
M
T
K
E
E
K
D
T
L
L
M
K
L
E
K
E
M
K
D
A
A
K
ALD
F
E
T
AA
N
V
R
D
M
I
L
E
LKASK
1
PsiBlast_PDB
82.27
73%
-90
- C4 -
-
2D7D
2
UVRB_BACSU
A:
[5-654]
---------
F
E
L
V
S
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
F
P
N
N
A
V
E
Y
F
V
S
Y
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
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K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
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D
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M
I
V
V
D
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S
H
V
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G
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Q
V
L
V
D
H
G
F
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L
P
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A
L
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N
R
P
L
R
F
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E
F
E
K
H
M
H
N
I
V
Y
V
S
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
E
Q
I
I
R
P
T
G
L
L
D
P
L
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D
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R
P
I
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G
Q
I
D
D
L
I
G
E
I
Q
A
R
I
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R
N
E
-
R
V
L
V
T
T
L
T
K
K
M
S
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D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
H
S
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I
K
T
L
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R
I
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I
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L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
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L
D
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P
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L
V
A
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L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
I
N
-----------------------------
K
K
E
R
Q
K
V
V
E
Q
M
E
H
E
M
K
E
A
A
K
A
L
D
F
E
R
A
A
E
L
R
D
L
L
-------
69
HHSearch
81.22
73%
-89
- C4 -
-
2NMV
3
?
A:
[5-654]
---------
F
E
L
V
-
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
F
P
N
N
A
V
E
Y
F
V
S
Y
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
-
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V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
M
H
N
I
V
Y
V
S
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
A
R
I
E
R
N
E
-
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
I
N
-----------------------------
K
K
E
R
Q
K
V
V
E
Q
M
E
H
E
M
K
E
A
A
K
A
L
D
F
E
R
A
A
E
L
R
D
L
L
-------
2
PsiBlast_PDB
81.22
73%
-89
- C4 -
-
2NMV
3
?
A:
[5-654]
---------
F
E
L
V
-
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
F
P
N
N
A
V
E
Y
F
V
S
Y
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
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K
D
A
S
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D
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I
D
K
L
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H
S
A
T
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F
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D
V
I
I
I
A
S
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S
C
I
Y
G
L
G
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P
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R
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M
V
V
S
L
R
T
E
M
E
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N
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L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
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D
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Q
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G
T
F
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R
G
D
V
V
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I
F
P
A
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D
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H
C
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V
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F
F
G
D
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I
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R
I
R
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D
A
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G
D
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D
H
V
A
I
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P
A
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F
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A
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K
M
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K
A
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Q
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I
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K
L
L
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Q
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L
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M
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G
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C
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P
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P
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T
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L
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L
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H
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H
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V
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P
Y
E
I
E
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T
D
E
-
M
V
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I
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R
P
T
G
L
L
D
P
L
I
D
V
R
P
I
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Q
I
D
D
L
I
G
E
I
Q
A
R
I
E
R
N
E
-
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
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G
I
K
V
N
Y
L
H
S
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I
K
T
L
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R
I
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I
I
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D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
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L
D
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P
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L
V
A
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D
A
D
K
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F
L
R
S
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R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
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G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
I
N
-----------------------------
K
K
E
R
Q
K
V
V
E
Q
M
E
H
E
M
K
E
A
A
K
A
L
D
F
E
R
A
A
E
L
R
D
L
L
-------
6
PsiBlast_PDB
80.71
73%
-94
- C4 -
-
1T5L
-
UVRB_BACCA
A:
[5-595]
---------
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
P
H
N
A
V
E
Y
F
V
S
Y
Y
D
Y
A
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
V
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
R
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
V
S
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
E
R
V
E
R
N
E
-
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
----------------------------------------------------------------
3
PsiBlast_PDB
79.87
73%
-96
- C4 -
-
3V4R
1
UVRB_BACSU
A:
[11-596]
---------
F
E
L
V
S
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
F
P
N
N
A
V
E
Y
F
V
S
Y
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
--
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
M
H
N
I
V
Y
V
S
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
A
R
I
E
R
N
E
-
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
I
N
K
---------------------------------------------------------------------
4
PsiBlast_PDB
79.29
73%
-90
- C4 -
-
3UWX
-
?
B:
[30-620]
---------
F
Q
L
V
S
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
L
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
H
S
E
L
K
E
F
F
P
H
N
A
V
E
Y
F
V
S
Y
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
V
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
R
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
I
S
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
H
E
R
V
E
R
N
E
-
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
----------------------------------------------------------------
21
PsiBlast_CBE
78.40
73%
-94
- C4 -
-
3V4R
1
?
B:
[11-595]
---------
F
E
L
V
S
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
F
P
N
N
A
V
E
Y
F
V
S
Y
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
--------
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
M
H
N
I
V
Y
V
S
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
A
R
I
E
R
N
E
-
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
I
N
----------------------------------------------------------------------
22
PsiBlast_CBE
77.75
73%
-97
- C4 -
-
2FDC
2
UVRB_BACCA
B:
[5-593]
---------
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
P
H
N
A
V
E
Y
F
V
S
Y
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
V
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
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R
G
T
F
R
V
R
G
D
V
V
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I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
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Y
D
L
E
M
M
R
E
M
G
F
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S
G
I
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Y
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H
L
A
L
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P
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Y
T
L
L
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Y
F
P
D
D
F
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I
I
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H
V
T
L
P
Q
L
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A
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Q
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L
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S
A
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N
R
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L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
V
S
A
T
P
G
P
Y
E
L
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H
S
P
G
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
R
P
T
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G
Q
I
D
D
L
I
G
E
I
R
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R
V
E
R
N
E
-
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
H
--------
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
------------------------------------------------------------------
92
Fugue
75.10
74%
-70
- C4 -
-
1D9X
-
UVRB_BACCA
A:
[2-595]
------
E
G
R
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
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N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
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A
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Y
F
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Y
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Y
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Y
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L
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L
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Y
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--
F
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-
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--
A
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A
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M
R
L
A
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I
E
Q
E
L
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R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
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R
T
R
Y
D
L
E
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M
R
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C
S
G
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N
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S
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H
L
A
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R
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P
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T
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L
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Y
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P
D
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Q
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L
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L
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A
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L
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F
E
E
F
E
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K
I
N
Q
I
I
Y
V
S
A
T
P
G
P
Y
E
L
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S
P
G
-
V
V
E
Q
I
I
R
P
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L
L
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V
R
P
T
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I
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D
L
I
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I
R
E
R
V
E
R
N
E
-
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
H
S
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I
K
T
L
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R
I
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I
I
R
D
L
R
L
G
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D
V
L
V
G
I
N
L
L
R
E
G
L
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I
P
E
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S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
N
A
--
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
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K
R
R
R
A
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E
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Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
----------------------------------------------------------------
7
PsiBlast_PDB
73.88
73%
-77
- C4 -
-
1D9Z
1
UVRB_BACCA
A:
[5-594]
---------
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
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S
N
V
I
A
Q
V
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K
P
--
T
L
V
I
A
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N
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T
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A
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Q
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L
K
E
F
F
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D
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M
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A
L
L
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R
L
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D
I
Q
Y
D
R
N
D
I
-
F
-
R
G
T
F
R
V
R
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D
V
V
E
I
F
P
A
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D
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F
F
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D
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--
R
-
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D
A
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L
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L
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L
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L
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L
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A
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K
E
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F
L
R
S
E
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L
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T
I
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R
A
A
R
-
N
-
A
N
G
H
V
I
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Y
A
D
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M
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I
A
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R
R
R
A
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E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
----------------------------------------------------------------
91
Fugue
71.29
57%
-89
- C4 -
-
1D2M
3
UVRB_THET8
A:
[2-583]
--------
T
F
R
Y
-
R
G
P
S
P
K
G
D
Q
P
K
A
I
A
G
L
V
E
A
L
R
D
G
E
R
F
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L
L
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A
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G
T
G
K
T
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T
M
A
K
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A
L
G
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P
--
A
L
V
L
A
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N
K
I
L
A
A
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L
A
A
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L
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F
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Y
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L
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A
-------
R
N
L
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L
L
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L
L
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L
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K
G
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L
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P
A
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P
-
I
R
V
E
L
------------------------
G
F
V
L
F
P
A
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H
Y
L
S
P
-
E
G
L
E
E
I
L
K
E
I
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K
E
L
W
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V
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Y
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E
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L
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L
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L
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L
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M
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P
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V
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N
Y
A
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Y
F
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K
A
P
G
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P
P
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T
L
L
D
Y
F
P
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L
V
F
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Q
L
Q
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Y
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R
P
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F
L
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Q
V
V
F
V
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A
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G
P
F
E
L
A
H
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R
-
V
V
E
Q
I
I
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P
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L
L
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L
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R
V
K
P
T
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Q
I
L
D
L
M
E
G
I
R
E
R
A
A
R
G
E
-
R
T
L
V
T
V
L
T
V
R
M
A
E
E
L
T
S
F
L
V
E
H
G
I
R
A
R
Y
L
H
H
E
L
D
A
F
K
R
Q
A
L
I
R
D
L
R
L
G
H
Y
D
C
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
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F
L
R
S
E
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S
L
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Q
T
I
G
R
A
A
R
-
N
-
A
R
G
E
V
W
L
Y
A
D
R
V
S
E
A
M
Q
R
A
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E
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T
N
R
R
R
A
L
Q
E
A
Y
N
L
E
H
G
I
T
P
E
T
V
-----------------------------------------------------------------------
8
PsiBlast_PDB
70.44
72%
-31
- C4 -
-
1D9X
-
UVRB_BACCA
A:
[5-595]
---------
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
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G
T
G
K
T
F
T
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S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
H
N
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T
L
A
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Q
L
Y
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L
K
E
F
F
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N
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E
Y
F
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Y
Y
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Q
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A
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F
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I
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C
I
Y
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L
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N
A
L
L
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R
L
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Y
D
R
N
D
I
-
F
-
R
G
T
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D
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V
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I
F
P
A
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R
D
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H
C
I
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E
F
F
G
D
E
I
E
---A
E
V
D
A
L
T
G
K
V
L
G
E
R
E
H
V
A
I
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A
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M
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A
Y
L
H
S
E
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
----------------------------------------------------------------
5
PsiBlast_PDB
69.97
73%
-92
- C4 -
-
2FDC
1
UVRB_BACCA
A:
[5-594]
---------
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
K
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
P
H
N
A
V
E
Y
F
V
S
Y
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
V
V
------------------------------------------------------------------------------------
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
V
S
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
E
R
V
E
R
N
E
-
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
H
------
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
-
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
-----------------------------------------------------------------
93
Fugue
48.18
72%
12
- C4 -
-
1D9X
-
UVRB_BACCA
A:
[2-414]
------
E
G
R
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
--KP
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
P
H
N
A
V
E
Y
F
V
S
Y
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
V
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
--
F
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
A
E
V
-
D
--
A
L
T
G
K
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
I
N
Q
I
I
Y
V
S
A
T
P
G
P
Y
E
L
E
H
S
P
-
G
V
V
E
Q
I
I
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Fugue
39.53
17%
-84
- C4 -
-
3HJH
-
MFD_ECOLI
A:
[5-450]
----------
Y
R
Y
T
L
P
V
K
A
G
E
-----------------
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
G
P
--
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
M
-----
V
M
N
L
A
D
W
E
T
L
P
Y
-
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
-------
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
-
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
----
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
P
E
H
I
Y
Q
Q
V
S
K
G
T
L
P
-------------
A
G
I
E
Y
W
Q
P
L
F
----
F
S
E
P
L
P
P
L
F
S
Y
F
P
A
N
T
L
L
V
N
T
G
D
--
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
R
P
L
L
P
P
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
N
W
P
R
V
Q
L
K
T
E
H
L
P
T
K
A
A
N
A
-
N
L
G
--
F
Q
K
L
P
D
L
-------
A
V
Q
A
Q
Q
K
A
P
L
D
A
L
R
K
F
L
E
T
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
M
R
L
D
E
------------
A
S
D
R
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
----------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
37.02
25%
-143
- C4 -
-
2V1X
1
RECQ1_HUMAN
A:
[266-378]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
Q
-
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
-----
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
-
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
------------------------------------------------------------------------------------------------------
83
HHSearch
35.94
25%
-151
- C4 -
-
4LJY
1
PRP5_YEAST
A:
[320-428]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
-
K
A
I
I
F
V
S
S
Q
N
I
C
D
F
I
S
K
K
L
L
N
A
G
I
V
T
C
A
I
H
A
G
K
P
Y
Q
E
R
L
M
N
L
E
K
F
K
R
E
K
N
S
I
L
L
C
T
E
V
L
S
R
G
L
N
V
P
E
V
S
L
V
I
I
Y
N
A
-----
V
K
T
F
A
Q
Y
V
H
T
T
G
R
T
A
R
-
G
S
R
S
G
T
A
I
T
L
L
L
H
D
E
------------------------------------------------------------------------------------------------------
80
HHSearch
35.94
25%
-135
- C4 -
-
4U7D
-
RECQ1_HUMAN
C:
[266-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
Q
-
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
-----
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
-
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
------------------------------------------------------------------------------------------------------
84
HHSearch
34.90
23%
-140
- C4 -
-
5IVL
-
?
B:
[239-351]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
E
-
L
A
I
V
F
G
R
T
K
R
R
V
D
E
L
A
E
A
L
N
L
R
G
Y
A
A
E
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
-----
P
Q
D
P
E
S
Y
V
H
R
I
G
R
T
G
R
-
A
G
K
T
G
V
A
M
T
F
V
T
P
R
E
------------------------------------------------------------------------------------------------------
81
HHSearch
34.62
18%
-133
- C4 -
-
1OYW
-
RECQ_ECOLI
A:
[235-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
K
-
S
G
I
I
Y
C
N
S
R
A
K
V
E
D
T
A
A
R
L
Q
S
K
G
I
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
D
D
L
Q
I
V
V
A
T
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
F
D
I
-----
P
R
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
-
D
G
L
P
A
E
A
M
L
F
Y
D
P
A
D
------------------------------------------------------------------------------------------------------