@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXA5: (2018-01-03 )
MFKGKTILVTGGTGSIGSEIVRQLLKYEPKAIRIYSRGEEKQFYMQQELSNHTNLRFLIGDIRDSQRIDYACRDVDIIFHAAAMKHVPASEYNPMEAVKTNVMGTQNVIDAAIKNNVKHFVGISTDKVVSPTNTMGATKLLSEKLIIAANQYKGKTETIFSCVRFGNVMGSSGSVIPLFSKQIKNNKDITLTDVDMTRFMMSIPDAARLVLSAAMNSKFGETYVLKMPAINILTLAQSLIKIYNDTHDEKYRGEIKVVGIRPGEKLYEELMTTDEIERSYENDKMYIIPPHYHATDELYKDYEKIKITAYSSDATELMSGQEFIRIAKENNVVTW
Atome Classification :
(20 SA)
--.........10........20.....-.-..30........40........50........60........70..--..--....80........90........100.......110.-----.-----.-----....120.......130.......140.......150.......160.......170.......180....-..-.190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.---...--.------..300..-----......--------.310....-...320.......330...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--MFKG
K
T
I
L
V
TGGTG
S
I
G
S
E
I
V
R
Q
L
L
K-Y-EP
K
A
I
R
I
Y
SRGE
E
K
Q
F
Y
M
Q
Q
E
LSNHT
N
L
R
F
L
I
GDIRDSQRI
D
Y
A
C
R
--
D
V
--
D
I
I
F
H
A
A
A
M
KHVPASEYN
P
M
E
A
V
K
T
NVMG
T
Q
N
V
I
D
A
A
I
-----
K
-----N-----N
V
K
H
FVGISTDKVVSPTNTM
G
A
T
K
L
L
SE
K
L
I
I
A
ANQYKG
K
T
E
T
I
F
S
C
V
R
F
G
N
VMGSSG
S
V
I
P
L
F
S
K
Q
IKNN-K
D
-
I
T
L
T
D
V
D
M
T
R
F
M
M
SI
P
D
A
A
R
L
V
L
S
A
A
MNSKFG
E
T
Y
V
L
KMP
A
I
N
I
L
T
L
A
Q
S
L
I
K
I
YNDTHDEKYRG
E
I
K
V
V
G
IR
P
G
E
K
L
Y
E
E
L
M
T
T
D
E
I
E
R
SYEND
K
M
Y
I
IPPHYH---
A
T
D
--
E
------
L
Y
K
--
D
Y
-----
E
K
I
K
I
T
--------AYSS
D
A
T
E
-
L
MS
G
Q
E
F
I
R
I
AKENNVVTW
40
HHSearch
96.70
39%
-69
- C1 -
-
3W1V
3
?
A:
[23-350]
---
F
D
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
-
S
-
N
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
N
-
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
S
V
E
T
A
M
R
--
D
V
--
D
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
A
I
-----
H
-----
Q
-----
N
V
K
K
V
I
C
L
S
T
D
K
A
A
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
A
K
S
R
N
I
R
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
V
I
P
L
F
I
D
K
I
K
A
G
-
E
P
-
L
T
I
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
E
T
G
D
I
M
V
Q
K
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
E
------
A
D
N
A
I
E
I
I
G
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
Y
A
Q
C
E
D
M
G
D
Y
F
R
V
P
A
D
S
R
---
D
L
N
YS
N
Y-----
V
E
T
G-
N
E
-----
K
I
T
Q
S
Y
--------
E
Y
N
S
D
N
T
H
-
I
L
T
V
E
E
I
K
E
K
L
L
T
L
E
Y
---
39
HHSearch
96.60
39%
-73
- C1 -
-
4G5H
17
?
A:
[23-350]
---
F
D
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
-
S
-
N
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
N
-
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
S
V
E
T
A
M
R
--
D
V
--
D
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
A
I
-----
H
-----
Q
-----
N
V
K
K
V
I
C
L
S
T
D
K
A
A
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
A
K
S
R
N
I
R
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
V
I
P
L
F
I
D
K
I
K
A
G
-
E
P
-
L
T
I
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
E
T
G
D
I
M
V
Q
K
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
E
------
A
D
N
A
I
E
I
I
G
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
Y
A
Q
C
E
D
M
G
D
Y
F
R
V
P
A
D
S
R
---
D
L
N
Y
S
N
Y
-----
V
E
T
G-
N
E
-----
K
I
T
Q
S
Y
--------
E
Y
N
S
D
N
T
H
-
I
L
T
V
E
E
I
K
E
K
L
L
T
L
E
Y
---
26
PsiBlast_CBE
93.96
40%
-77
- C1 -
-
3W1V
3
?
B:
[23-340]
---
F
D
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
-
S
-
N
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
-
N
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
S
V
E
T
A
M
R
--
D
V
--
D
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
A
I
-----
H
-----
Q
-----
N
V
K
K
V
I
C
L
S
T
D
K
A
A
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
A
K
S
R
N
I
R
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
V
I
P
L
F
I
D
K
I
K
A
G
-
E
P
-
L
T
I
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
E
T
G
D
I
M
V
Q
K
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
E
A
D
N
------
A
I
E
I
I
G
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
Y
A
Q
C
E
D
M
G
D
Y
F
R
V
P
A
--
D
---
S
R
D
--
L
------
N
Y
S
--
N
Y
VETGN
E
K
I
T
Q
S
Y-------
E
Y
N
S
D
N
T
H
-
I
L
T
V
E
E
-------------
7
PsiBlast_PDB
92.06
40%
-81
- C1 -
-
4G5H
17
?
A:
[23-340]
---
F
D
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
-
S
-
N
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
-
N
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
S
V
E
T
A
M
R
--
D
V
--
D
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
A
I
-----
H
-----
Q
-----
N
V
K
K
V
I
C
L
S
T
D
K
A
A
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
A
K
S
R
N
I
R
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
V
I
P
L
F
I
D
K
I
K
A
G
-
E
P
-
L
T
I
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
E
T
G
D
I
M
V
Q
K
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
E
A
D
N
------
A
I
E
I
I
G
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
Y
A
Q
C
E
D
M
G
D
Y
F
R
V
P
A
--
D
---
S
R
D
--
L
------
N
Y
S
--
N
Y
V
ETGN
E
K
I
T
Q
S
Y
-------
E
Y
N
S
D
N
T
H
-
I
L
T
V
E
E
-------------
6
PsiBlast_PDB
91.84
40%
-79
- C1 -
-
3W1V
3
?
A:
[23-340]
---
F
D
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
-
S
-
N
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
-
N
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
S
V
E
T
A
M
R
--
D
V
--
D
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
A
I
-----
H
-----
Q
-----
N
V
K
K
V
I
C
L
S
T
D
K
A
A
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
A
K
S
R
N
I
R
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
V
I
P
L
F
I
D
K
I
K
A
G
-
E
P
-
L
T
I
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
E
T
G
D
I
M
V
Q
K
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
E
A
D
N
------
A
I
E
I
I
G
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
Y
A
Q
C
E
D
M
G
D
Y
F
R
V
P
A
--
D
---
S
R
D
--
L
------
N
Y
S
--
N
Y
VETGN
E
K
I
T
Q
S
Y
-------
E
Y
N
S
D
N
T
H
-
I
L
T
V
E
E
-------------
41
HHSearch
87.76
42%
-13
- C1 -
-
2GN4
3
PSEB_HELPY
A:
[19-344]
---
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
-
T
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
-
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-----
K
-----
N
-----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
S
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
V
P
K
I
P
S
M
K
M
T
D
L
A
K
A
L
A
P
N
T
P
----------
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
T
I
S
---
F
Q
T
--
P
K
D
YTLT
K
L
H
E
K
G
Q
-----
K
V
A
P
D
F
--------
E
Y
S
S
H
N
N
N
Q
W
L
E
P
D
D
L
L
K
L
L
--------
23
PsiBlast_CBE
86.21
44%
-30
- C1 -
-
2GN8
3
PSEB_HELPY
B:
[18-298]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
-
T
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
-
N
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-----
K
-----
N
-----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
S
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
V
P
K
I
P
S
M
K
M
T
D
L
A
K
A
L
A
P
----------
N
T
P
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
------------------------------------------------------------------------
1
PsiBlast_PDB
84.98
44%
-28
- C1 -
-
2GN4
3
PSEB_HELPY
A:
[18-298]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
-
T
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
-
N
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-----
K
-----
N
-----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
S
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
V
P
K
I
P
S
M
K
M
T
D
L
A
K
A
L
A
P
----------
N
T
P
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
------------------------------------------------------------------------
25
PsiBlast_CBE
84.81
44%
-29
- C1 -
-
2GN4
4
PSEB_HELPY
B:
[18-298]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
-
T
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
-
N
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-----
K
-----
N
-----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
S
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
V
P
K
I
P
S
M
K
M
T
D
L
A
K
A
L
A
P
----------
N
T
P
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
------------------------------------------------------------------------
27
Fugue
84.02
42%
13
- C1 -
-
2GN4
3
PSEB_HELPY
A:
[16-344]
QN
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
-
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
-
N
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-----
K
-----
N
-----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
V
P
K
I
P
S
M
K
M
T
D
L
A
K
A
L
A
P
----------
N
T
P
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
T
I
S
---
F
Q
T
--
P
------
K
D
Y
--
T
L
-----
T
K
L
H
E
K
G
Q
K
V
A
PDF
E
Y
S
S
H
N
N
N
-
Q
W
L
E
P
D
D
L
L
K
L
L
-------
21
PsiBlast_CBE
83.81
44%
-32
- C1 -
-
2GNA
3
PSEB_HELPY
B:
[18-298]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
-
T
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
-
N
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-----
K
-----
N
-----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
S
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
V
P
K
I
P
S
M
K
M
T
D
L
A
K
A
L
A
P
----------
N
T
P
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
------------------------------------------------------------------------
3
PsiBlast_PDB
83.57
44%
-29
- C1 -
-
2GN8
3
PSEB_HELPY
A:
[18-298]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
-
T
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
-
N
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-----
K
-----
N
-----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
S
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
V
P
K
I
P
S
M
K
M
T
D
L
A
K
A
L
A
P
----------
N
T
P
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
------------------------------------------------------------------------
24
PsiBlast_CBE
82.77
44%
-33
- C1 -
-
2GN6
3
PSEB_HELPY
B:
[18-298]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
-
T
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
-
N
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-----
K
-----
N
-----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
S
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
V
P
K
I
P
S
M
K
M
T
D
L
A
K
A
L
A
P
----------
N
T
P
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
------------------------------------------------------------------------
5
PsiBlast_PDB
81.90
44%
-32
- C1 -
-
2GNA
2
PSEB_HELPY
A:
[18-298]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
-
T
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
-
N
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-----
K
-----
N
-----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
S
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
V
P
K
I
P
S
M
K
M
T
D
L
A
K
A
L
A
P
----------
N
T
P
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
------------------------------------------------------------------------
4
PsiBlast_PDB
81.38
44%
-32
- C1 -
-
2GN9
2
PSEB_HELPY
A:
[18-298]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
-
T
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
-
N
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-----
K
-----
N
-----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
S
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
V
P
K
I
P
S
M
K
M
T
D
L
A
K
A
L
A
P
----------
N
T
P
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
------------------------------------------------------------------------
2
PsiBlast_PDB
81.28
44%
-30
- C1 -
-
2GN6
2
PSEB_HELPY
A:
[18-298]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
-
T
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
-
N
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-----
K
-----
N
-----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
S
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
V
P
K
I
P
S
M
K
M
T
D
L
A
K
A
L
A
P
----------
N
T
P
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
------------------------------------------------------------------------
22
PsiBlast_CBE
80.60
44%
-29
- C1 -
-
2GN9
4
PSEB_HELPY
B:
[18-298]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
-
T
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
-
N
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-----
K
-----
N
-----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
S
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
V
P
K
I
P
S
M
K
M
T
D
L
A
K
A
L
A
P
----------
N
T
P
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
------------------------------------------------------------------------
37
HHSearch
71.58
33%
-28
- C1 -
-
4TQG
1
?
A:
[2-319]
--
Q
I
N
D
K
T
I
M
I
F
G
G
S
G
S
L
G
N
R
L
I
E
T
Y
I
N
-
N
--
N
-
I
I
V
N
Y
S
R
D
E
S
K
H
W
S
M
E
L
K
Y
K
-
S
D
K
L
K
N
I
I
G
D
I
R
D
F
E
K
V
Q
Q
S
I
M
R
I
N
P
--
D
I
I
I
I
A
A
A
L
K
H
I
D
R
C
E
Y
E
I
N
E
C
L
D
T
N
I
K
G
L
Q
N
V
L
K
V
T
E
I
NRSN
L
-----
S
-----
N
L
K
A
V
C
F
V
S
T
D
K
A
C
S
P
V
N
S
Y
G
M
S
K
A
I
C
E
T
L
V
V
E
K
S
K
Y
I
--
K
D
I
K
Y
V
C
V
R
Y
G
N
V
L
N
--------------------
F
T
L
T
H
T
S
M
T
R
F
I
M
T
L
D
D
S
V
K
L
I
E
Y
A
I
I
N
G
N
S
G
E
I
V
I
P
K
L
N
S
M
Y
I
K
D
M
I
E
L
F
A
D
K
Y
----------
P
I
V
I
T
G
L
R
S
G
E
R
M
Y
E
S
L
I
N
D
T
Q
S
M
K
T
V
P
K
G
D
Y
Y
H
I
L
P
T
Y
D
---
P
T
I
--
V
-------------------
T
E
E
F
Y
--------
E
Y
S
S
K
Q
-
N
-
I
L
S
K
Q
E
L
E
N
Y
L
N
Q
------
28
Fugue
69.24
33%
2
- C1 -
-
4TQG
1
?
A:
[1-319]
-S
Q
I
N
D
K
T
I
M
I
F
G
G
S
G
S
L
G
N
R
L
I
E
T
Y
I
N
----
N
N
I
I
V
N
Y
S
R
D
E
S
K
H
W
S
M
E
L
K
Y
K
S
-
D
K
L
K
N
I
I
G
D
I
R
D
F
E
K
V
Q
Q
S
I
M
--
R
I
NP
D
I
I
I
I
A
A
A
L
K
H
I
D
R
C
E
Y
E
I
N
E
C
L
D
T
N
I
K
G
L
Q
N
V
L
K
V
T
E
-----
I
NRSNL
S
-----
N
L
K
A
V
C
F
V
S
T
D
K
A
C
S
P
V
N
S
Y
G
M
S
K
A
I
C
E
T
L
V
V
E
K
S
K
Y
I
--
K
D
I
K
Y
V
C
V
R
Y
G
N
V
L
N
--------------------
F
T
L
T
H
T
S
M
T
R
F
I
M
T
L
D
D
S
V
K
L
I
E
Y
A
I
I
N
G
N
S
G
E
I
V
I
P
K
L
N
S
M
Y
I
K
D
M
I
E
L
F
A
D
K
Y
----------
P
I
V
I
T
G
L
R
S
G
E
R
M
Y
E
S
L
I
N
D
T
Q
S
M
K
T
V
P
K
G
D
Y
Y
H
I
L
P
T
Y
D
---
P
T
I
--
V
------
T
E
E
--
F
Y
-----
E
--------------
Y
S
S
K
-
Q
N
-
I
L
S
K
Q
E
L
E
N
Y
L
N
Q
------
8
PsiBlast_PDB
62.67
32%
-35
- C1 -
-
4TQG
1
?
A:
[6-300]
------
K
T
I
M
I
F
G
G
S
G
S
L
G
N
R
L
I
E
T
Y
I
N
----
N
N
I
I
V
N
Y
S
R
D
E
S
K
H
W
S
M
E
L
K
Y
K
S
D
K
-
L
K
N
I
I
G
D
I
R
D
F
E
K
V
Q
Q
S
I
M
--
R
I
NP
D
I
I
I
I
A
A
A
L
K
H
I
D
R
C
E
Y
E
I
N
E
C
L
D
T
N
I
K
G
L
Q
N
V
L
K
V
T
E
-----
I
-----
N
RSNLS
N
L
K
A
V
C
F
V
S
T
D
K
A
C
S
P
V
N
S
Y
G
M
S
K
A
I
C
E
T
L
V
V
E
K
S
K
Y
I
K
D
I
K
--
Y
V
C
V
R
Y
G
N
V
L
N
--------------------
F
T
L
T
H
T
S
M
T
R
F
I
M
T
L
D
D
S
V
K
L
I
E
Y
A
I
I
N
G
N
S
G
E
I
V
I
P
K
L
N
S
M
Y
I
----
K
D
M
I
E
L
F
A
D
----
K
Y
--
P
I
V
I
T
G
L
R
S
G
E
R
M
Y
E
S
L
I
N
D
T
Q
S
M
K
T
V
P
K
G
D
Y
Y
H
I
L
P
T
Y
D
PTI
V
T
E
--
E
------
F
Y
E
---------------------------------------------------