@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXB8: (2018-01-03 )
MTKILEVKDLEISFDTYAGKVRAIRGVNFHLNKGETLAIVGESGSGKSVTTRSIMRLLSSNANIDAGQILFKGNDIVGKSEREMQKIRGKEIAMIFQDPMTSLDPTMPIGKQVAESLRKHNKVSKKEGQKAALELLKLVGIPEAEKRINSYPHQFSGGQRQRIVIAIALVCYPEILIADEPTTALDVTIQAQILELLKEIQTKIDTSIIFITHDLGVVANVADRVAVMYGGRIVEVGTSEEIFYNPQHPYTWGLLGSMPTLDSANDRLYAIPGSPPDLLNPPKGDAFYPRNEFAMKIDAEQEPPFFELSKTHKAATWLLAPQAPKVTPPEEIQRRWAIFKEKQKHTYGQGGIADAK
Atome Classification :
(44 SA)
.........10---........20.........30........40........50........60........70........80........90........----------100.......110.--......120.-...-....130.......140........150..----.....160.......170.......180.......190.......200.......210.......220.......230.......240.-----......250.......260....---...270----........280.......290.......300.......310.......320.......330.......340.......350....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
K
I
L
E
V
K
D
L
E
---
I
S
F
DTYA
G
K
-
V
R
A
I
R
G
V
N
F
H
LNKG
E
T
L
A
I
V
GESGSGKS
V
T
T
R
S
I
M
R
L
L
SSNANIDA
G
Q
I
L
F
KGNDIVG
K
S
E
R
E
M
Q
K
IRGK
E
I
A
M
I
F
QDP----------MTSLDPTMP
I
G
K
Q
V
--
A
E
S
L
R
KHN-K-V
S
K
-KE
G
Q
K
A
A
L
E
L
L
K
L
VGI-
P
E
A
E
K
R
I
N
SYPHQ----FSGG
Q
R
Q
R
I
V
I
A
I
A
LVCY
P
E
I
L
IADEPT
T
A
L
D
V
T
I
Q
A
Q
I
L
E
L
L
K
E
I
Q
T
KID
T
S
I
I
F
I
THD
L
G
V
V
A
N
V
A
D
R
V
A
V
M
YG
G
R
I
V
EVGTSE
E
I
F
-----YNPQH
P
Y
TWGLLGSMPTLDSAN
D
---
R
L
Y
AI-----PGSPPDLLNPPKGDAFYPRN
E
F
A
M
K
IDAEQEPP
F
F
E
LSKTHK
A
A
T
W
L
LAPQAPKVT
P
P
E
E
I
Q
R
R
W
A
I
F
K
E
K
Q
KHTYGQGGIADAK
115
HHSearch
88.07
41%
-67
- C1 -
-
4FWI
2
?
B:
[2-321]
-
S
I
I
I
R
V
E
D
L
R
---
A
V
Y
L
V
R
E
G
T
-
I
K
A
A
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
N
G
R
I
L
S
G
R
V
L
Y
K
G
K
D
L
L
T
M
R
E
E
E
L
R
K
I
R
W
K
E
I
A
L
V
P
Q
A
A
----------
Q
Q
S
L
N
P
T
M
K
V
I
E
H
F
--
K
D
T
V
E
A
H
G
-
V
R
W
S
H
-
S
E
L
I
E
K
A
S
E
K
L
R
M
V
R
L
-
N
P
-
E
A
V
L
N
S
Y
P
L
Q
----
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
L
V
E
Y
N
S
T
F
Q
I
F
-----
K
N
P
L
H
P
Y
T
R
G
L
I
N
S
I
M
-------------
P
I
-----
P
G
D
P
P
S
L
L
N
P
P
S
G
C
R
F
H
P
R
C
E
Y
A
M
E
I
C
K
K
E
K
P
K
W
I
R
L
D
G
E
A
H
V
A
C
H
L
Y
E
E
-----------------------------------
1
PsiBlast_PDB
84.60
41%
-52
- C1 -
-
4FWI
2
?
B:
[2-318]
-
S
I
I
I
R
V
E
D
L
R
---
A
V
Y
L
V
R
E
G
T
-
I
K
A
A
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
N
G
R
I
L
S
G
R
V
L
Y
K
G
K
D
L
L
T
M
R
E
E
E
L
R
K
I
R
W
K
E
I
A
L
V
P
Q
A
A
----------
Q
Q
S
L
N
P
T
M
K
V
I
E
H
F
--
K
D
T
V
E
A
H
G
V
R
-
W
S
H
-
S
E
L
I
E
K
A
S
E
K
L
R
M
V
R
L
N
P
E
A
--
V
L
N
S
Y
P
L
Q
----
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
L
V
E
Y
N
S
T
F
Q
I
F
-----
K
N
P
L
H
P
Y
T
R
G
L
I
N
S
I
M
-------------
P
I
-----
P
G
D
P
P
S
L
L
N
P
P
S
G
C
R
F
H
P
R
C
E
Y
A
M
E
I
C
K
K
E
K
P
K
W
I
R
L
D
G
E
A
H
V
A
C
H
L
--------------------------------------
24
PsiBlast_CBE
73.61
33%
-139
- C1 -
-
3C4J
2
?
B:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
---
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------------
F
N
L
F
P
H
M
T
V
L
N
N
I
--
T
L
A
P
M
K
V
R
-
K
-
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
---
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.05
33%
-138
- C1 -
-
2OLJ
3
?
A:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
---
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------------
F
N
L
F
P
H
M
T
V
L
N
N
I
--
T
L
A
P
M
K
V
R
-
K
-
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
---
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.04
35%
-142
- C1 -
-
3TUI
1
METN_ECOLI
C:
[41-284]
------------------------
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
------------
F
N
L
L
S
S
R
T
V
F
G
N
V
--
A
L
P
L
E
L
D
N
---
T
P
K
-
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
---
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
YQE
R
L
Q
A
E
-----
P
------------------------------------------------------------------------------------
30
PsiBlast_CBE
72.84
33%
-136
- C1 -
-
2OLK
1
?
C:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
---
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------------
F
N
L
F
P
H
M
T
V
L
N
N
I
--
T
L
A
P
M
K
V
R
-
K
-
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
---
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.65
35%
-148
- C1 -
-
3TUZ
1
METN_ECOLI
C:
[41-284]
------------------------
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
------------
F
N
L
L
S
S
R
T
V
F
G
N
V
--
A
L
P
L
E
L
D
N
---
T
P
K
-
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
---
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
YQE
R
L
Q
A
E
-----
P
------------------------------------------------------------------------------------
119
HHSearch
72.25
33%
-143
- C1 -
-
3TUI
1
METN_ECOLI
C:
[23-269]
--
H
M
I
K
L
S
N
I
T
---
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
-
R
R
Q
I
G
M
I
F
Q
H
F
----------
N
--
L
L
S
S
R
T
V
F
G
N
V
--
A
L
P
L
E
L
D
N
---
T
P
K
-
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
---
D
K
H
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
--------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.25
33%
-138
- C1 -
-
2OUK
-
?
A:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
---
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------------
F
N
L
F
P
H
M
T
V
L
N
N
I
--
T
L
A
P
M
K
V
R
-
K
-
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
---
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
71.69
33%
-135
- C1 -
-
2OLK
1
?
D:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
---
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------------
F
N
L
F
P
H
M
T
V
L
N
N
I
--
T
L
A
P
M
K
V
R
-
K
-
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
---
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.54
33%
-138
- C1 -
-
2OLK
1
?
A:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
---
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------------
F
N
L
F
P
H
M
T
V
L
N
N
I
--
T
L
A
P
M
K
V
R
-
K
-
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
---
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.48
33%
-133
- C1 -
-
3C4J
2
?
A:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
---
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------------
F
N
L
F
P
H
M
T
V
L
N
N
I
--
T
L
A
P
M
K
V
R
-
K
-
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
---
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
71.02
35%
-145
- C1 -
-
3TUZ
1
METN_ECOLI
G:
[41-284]
------------------------
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
------------
F
N
L
L
S
S
R
T
V
F
G
N
V
--
A
L
P
L
E
L
D
N
---
T
P
K
-
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
---
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
YQE
R
L
Q
A
E
-----
P
------------------------------------------------------------------------------------
25
PsiBlast_CBE
70.85
33%
-137
- C1 -
-
2Q0H
3
?
B:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
---
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------------
F
N
L
F
P
H
M
T
V
L
N
N
I
--
T
L
A
P
M
K
V
R
-
K
-
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
---
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
70.67
33%
-135
- C1 -
-
3C41
2
?
K:
[2-238]
--
Q
M
I
D
V
H
Q
L
K
---
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------------
F
N
L
F
P
H
M
T
V
L
N
N
I
--
T
L
A
P
M
K
V
R
-
K
-
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
---
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
70.65
33%
-135
- C1 -
-
2OLK
2
?
B:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
---
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------------
F
N
L
F
P
H
M
T
V
L
N
N
I
--
T
L
A
P
M
K
V
R
-
K
-
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
---
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
69.99
33%
-133
- C1 -
-
2Q0H
3
?
A:
[23-259]
--
Q
M
I
D
V
H
Q
L
K
---
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
----
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------------
F
N
L
F
P
H
M
T
V
L
N
N
I
--
T
L
A
P
M
K
V
R
-
K
-
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
---
K
A
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------
107
Fugue
69.82
27%
-109
- C1 -
-
3TUZ
1
METN_ECOLI
H:
[23-362]
--
H
M
I
K
L
S
N
I
T
---
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
----
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
------------
N
L
L
S
S
R
T
V
F
G
N
V
--
A
L
P
L
E
L
D
N
-
T
--
P
K
-
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
---
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
---
Y
Q
E
R
L
QAEPF
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
--------
H
V
K
V
E
V
37
PsiBlast_CBE
69.82
35%
-149
- C1 -
-
3TUI
1
METN_ECOLI
H:
[41-284]
------------------------
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
------------
F
N
L
L
S
S
R
T
V
F
G
N
V
--
A
L
P
L
E
L
D
N
---
T
P
K
-
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
---
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
YQE
R
L
Q
A
E
-----
P
------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.47
34%
-118
- C1 -
-
4U02
-
?
A:
[1-238]
M
E
P
I
I
R
I
R
N
L
H
---
K
W
F
----
G
P
-
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
--
K
D
D
R
A
L
R
E
I
R
-
R
E
V
G
M
V
F
Q
Q
------------
F
N
L
F
P
H
M
T
V
L
E
N
V
--
T
L
A
P
M
R
V
R
-
R
-
W
P
R
-
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
-
L
D
Q
A
R
K
---
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
-----
T
R
P
K
E
E
R
T
R
S
F
L
-------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
28.23
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
B:
[341-581]
--------
D
L
E
FRN
V
T
F
-
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
----
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
---
R
E
Y
T
L
A
S
L
R
-
N
Q
V
A
L
V
S
Q
N
V
----------
H
L
F
N
D
T
---
V
A
N
N
I
--
A
Y
A
--
R
T
E
-
E
-
Y
S
R
-
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
NGVL
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
R
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
AQHGV
Y
A
Q
L
H
K
M
Q
F
G
---------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
28.22
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
A:
[341-581]
--------
D
L
E
FRN
V
T
F
-
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
----
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
---
R
E
Y
T
L
A
S
L
R
-
N
Q
V
A
L
V
S
Q
N
V
----------
H
L
F
N
D
T
---
V
A
N
N
I
--
A
Y
A
--
R
T
E
-
E
-
Y
S
R
-
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
NGVL
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
R
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
HG
V
Y
A
Q
L
H
K
M
Q
F
G
---------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
28.22
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
C:
[341-581]
--------
D
L
E
FRN
V
T
F
-
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
----
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
---
R
E
Y
T
L
A
S
L
R
-
N
Q
V
A
L
V
S
Q
N
V
----------
H
L
F
N
D
T
---
V
A
N
N
I
--
A
Y
A
--
R
T
E
-
E
-
Y
S
R
-
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
NGVL
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
R
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
AQHGV
Y
A
Q
L
H
K
M
Q
F
G
---------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
28.19
32%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
B:
[341-581]
--------
D
L
E
FRN
V
T
F
-
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
----
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
---
R
E
Y
T
L
A
S
L
R
-
N
Q
V
A
L
V
S
Q
N
V
----------
H
L
F
N
D
T
---
V
A
N
N
I
--
A
Y
A
--
R
T
E
-
E
-
Y
S
R
-
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
NGVL
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
R
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
AQHGV
Y
A
Q
L
H
K
M
Q
F
G
---------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
28.18
32%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
A:
[341-581]
--------
D
L
E
F
R
N
V
T
F
-
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
----
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
---
R
E
Y
T
L
A
S
L
R
-
N
Q
V
A
L
V
S
Q
N
V
----------
H
L
F
N
D
T
---
V
A
N
N
I
--
A
Y
A
--
R
T
E
-
E
-
Y
S
R
-
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
NGVL
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
R
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
HGV
Y
A
Q
L
H
K
M
Q
F
G
---------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
28.16
32%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
C:
[341-581]
--------
D
L
E
FRN
V
T
F
-
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
----
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
---
R
E
Y
T
L
A
S
L
R
-
N
Q
V
A
L
V
S
Q
N
V
----------
H
L
F
N
D
T
---
V
A
N
N
I
--
A
Y
A
--
R
T
E
-
E
-
Y
S
R
-
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
NGVL
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
R
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
AQHGV
Y
A
Q
L
H
K
M
Q
F
G
---------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
27.87
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
D:
[341-580]
--------
D
L
E
FRN
V
T
F
-
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
----
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
---
R
E
Y
T
L
A
S
L
R
-
N
Q
V
A
L
V
S
Q
N
V
----------
H
L
F
N
D
T
---
V
A
N
N
I
--
A
Y
A
--
R
T
E
-
E
-
Y
S
R
-
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
NGVL
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
R
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
AQHGV
Y
A
Q
L
H
K
M
Q
F
----------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
27.79
32%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
D:
[341-580]
--------
D
L
E
FRN
V
T
F
-
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
----
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
---
R
E
Y
T
L
A
S
L
R
-
N
Q
V
A
L
V
S
Q
N
V
----------
H
L
F
N
D
T
---
V
A
N
N
I
--
A
Y
A
--
R
T
E
-
E
-
Y
S
R
-
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
NGVL
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
R
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
AQHGV
Y
A
Q
L
H
K
M
Q
F
----------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
26.20
31%
9
- C1 -
-
1XEF
2
HLYBP_ECOLX
C:
[22-234]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRSIIDN
I
S
L
A
N
P
G
M
S
V
E
K
V
I
YA
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
25.62
31%
12
- C1 -
-
2FGJ
2
HLYBP_ECOLX
B:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRSIIDN
I
S
L
A
N
P
G
M
S
V
E
K
V
I
YA
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
25.58
31%
12
- C1 -
-
1XEF
2
D:
[22-234]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRSIIDN
I
S
L
A
N
P
G
M
S
V
E
K
V
I
YA
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
25.43
31%
7
- C1 -
-
2FGJ
2
HLYBP_ECOLX
C:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRSIIDN
I
S
L
A
N
P
G
M
S
V
E
K
V
I
YA
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
25.25
31%
8
- C1 -
-
2FGK
2
HLYBP_ECOLX
A:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRS
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
25.07
31%
9
- C1 -
-
1XEF
2
HLYBP_ECOLX
B:
[22-234]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRSIIDN
I
S
L
A
N
P
G
M
S
V
E
K
V
I
YA
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
24.99
32%
6
- C1 -
-
2PMK
1
A:
[24-236]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRS
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
24.72
31%
10
- C1 -
-
1XEF
2
HLYBP_ECOLX
A:
[22-234]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
NRS
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
24.08
31%
10
- C1 -
-
2FGJ
2
HLYBP_ECOLX
A:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
V
L
L
NRS
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
23.85
31%
8
- C1 -
-
2FGK
2
HLYBP_ECOLX
C:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRSIIDN
I
S
L
A
N
P
G
M
S
V
E
K
V
I
YA
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
23.79
32%
13
- C1 -
-
2FF7
1
A:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRS
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
23.64
31%
11
- C1 -
-
3B5J
1
A:
[24-236]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRS
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
23.48
31%
13
- C1 -
-
2FFA
2
A:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRS
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
22.88
31%
17
- C1 -
-
2FGJ
2
D:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRSIIDN
I
S
L
A
N
P
G
M
S
V
E
K
V
I
YA
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
22.34
31%
8
- C1 -
-
2FGK
2
HLYBP_ECOLX
B:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRSIIDN
I
S
L
A
N
P
G
M
S
V
E
K
V
I
YA
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
20.74
31%
9
- C1 -
-
2FGK
2
D:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
N
VLLNRSIIDN
I
S
L
A
N
P
G
M
S
V
E
K
V
I
YA
A
K
L
A
G
A
H
D
-
F
-
I
S
E
L
R
E
G
Y
N
T
------
I
V
G
E
-
Q
G
A
---------
G
----
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
-----
S
E
P
E
S
L
Y
S
Y
----------------------------------------------------------------------------------------------------------------