@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXB9: (2018-01-03 )
MPNKLLEVKGLKQYFNVGKKNEVHAVNDISFHIYEGETFGLVGESGSGKSTTGRTIIRLNEPTDGEILFDGQDITKIKDKKGLTKFRHDVQMIFQDPYASLNPRMKVRDIIAEGIDVNGLAKSSEERAKKVDDLLRTVGLNPSHGTRYPHEFSGGQRQRIGIARALAVKPRFIICDEPISALDVSIQAQVVNLLQDLQKEHQLTYLFIAHDLSMVKHISDRIGVMHNGLLLEMGTSDEIYNHGVHPYTESLLSAIPLPDPDHERKRRRIKYQPEPDDGQVRQLREIAPEHFVYATEQEVPYYAKKLKRQKESLLVAN
Atome Classification :
(41 SA)
.........10........20........30........40........50........60..----......70........80....---------....90..------.....----------.100.......110..-.....120-..-.....130.....-..140-.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240........250-------------------.......260.......270..----------.....280..--.....290.......300.......310.....---------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPN
K
L
L
E
V
K
G
L
K
Q
Y
F
NVGKKNE
V
H
A
V
N
D
I
S
F
H
I
YEG
E
T
F
G
L
VGESGSGKSTTG
R
T
I
I
R
LNEPT----DG
E
I
L
FDGQ
D
I
T
K
I
KDKK
G
L
T
K
---------
F
R
H
D
V
Q
M
I
------
F
QDPY----------ASLNP
R
M
K
V
R
D
I
I
AEG-IDVNGLAK-
S
S
-
E
E
R
A
K
K
V
D
D
L
L
R
T-VGLNP-SHGTRYPHEFSGGQ
R
Q
R
I
G
I
A
R
A
LAVK
P
R
F
I
I
CDEPI
S
A
L
D
V
S
I
Q
A
Q
V
V
N
L
L
Q
D
L
Q
K
EHQ
L
T
Y
L
F
I
A
H
D
L
S
M
V
K
H
I
S
D
R
I
G
V
MHN
G
L
L
L
EMGTS
D
E
I
Y
-NHGV
H
P
Y
T
E
S
L
L
-------------------
S
AIPLPDP
D
H
E
R
K
R
R
RIKYQPE----------PDD
G
Q
V
R
Q
L
R
--
E
IAPE
H
F
V
Y
ATEQEV
P
Y
Y
A
K
K
L
K
R
Q
K
E
SLLVAN---------------------------------------------
3
PsiBlast_PDB
97.74
34%
-142
- C1 -
-
3TUZ
1
METN_ECOLI
C:
[24-293]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
-
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
--
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
D
-
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
A
Q
K
F
I
Q------------------
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
----
L
Q
A
E
----------
P
F
T
D
C
V
P
M
L
R
--------------------------------------------------------------------------------
24
PsiBlast_CBE
94.49
34%
-141
- C1 -
-
3TUI
1
METN_ECOLI
H:
[24-293]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
-
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
--
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
D
-
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
A
Q
K
F
I
Q------------------
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
----
L
Q
A
E
----------
P
F
T
D
C
V
P
M
L
R
--------------------------------------------------------------------------------
2
PsiBlast_PDB
93.78
34%
-135
- C1 -
-
3TUI
1
METN_ECOLI
C:
[24-293]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
-
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
--
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
D
-
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
A
Q
K
F
I
Q------------------
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
----
L
Q
A
E
----------
P
F
T
D
C
V
P
M
L
R
--------------------------------------------------------------------------------
21
PsiBlast_CBE
92.33
34%
-139
- C1 -
-
3TUZ
1
METN_ECOLI
H:
[24-293]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
-
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
--
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
D
-
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
A
Q
K
F
I
Q------------------
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
----
L
Q
A
E
----------
P
F
T
D
C
V
P
M
L
R
--------------------------------------------------------------------------------
26
PsiBlast_CBE
92.01
34%
-132
- C1 -
-
3TUI
1
METN_ECOLI
D:
[24-293]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
-
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
--
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
D
-
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
A
Q
K
F
I
Q------------------
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
----
L
Q
A
E
----------
P
F
T
D
C
V
P
M
L
R
--------------------------------------------------------------------------------
4
PsiBlast_PDB
91.24
34%
-140
- C1 -
-
3TUJ
-
METN_ECOLI
C:
[2-270]
-----
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
-
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
--
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
D
-
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
A
Q
K
F
I
Q------------------
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
----
L
Q
A
E
----------
P
F
T
D
C
V
P
M
L
R
--------------------------------------------------------------------------------
23
PsiBlast_CBE
91.10
34%
-137
- C1 -
-
3TUZ
1
METN_ECOLI
D:
[24-293]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
-
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
--
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
D
-
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
A
Q
K
F
I
Q------------------
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
----
L
Q
A
E
----------
P
F
T
D
C
V
P
M
L
R
--------------------------------------------------------------------------------
25
PsiBlast_CBE
90.56
34%
-130
- C1 -
-
3TUI
1
METN_ECOLI
G:
[24-293]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
-
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
--
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
D
-
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
A
Q
K
F
I
Q------------------
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
----
L
Q
A
E
----------
P
F
T
D
C
V
P
M
L
R
--------------------------------------------------------------------------------
22
PsiBlast_CBE
89.87
34%
-134
- C1 -
-
3TUZ
1
METN_ECOLI
G:
[24-293]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
-
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
--
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
D
-
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
A
Q
K
F
I
Q------------------
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
----
L
Q
A
E
----------
P
F
T
D
C
V
P
M
L
R
--------------------------------------------------------------------------------
160
HHSearch
81.92
35%
-133
- C1 -
-
3TUI
1
METN_ECOLI
C:
[23-259]
---
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
-
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
-
S
E
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
H
F
N
------------
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
P
---
K
-
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
--
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------
140
Fugue
80.02
29%
-124
- C1 -
-
3TUZ
1
METN_ECOLI
H:
[23-362]
---
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
-
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
-
E
S
E
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
H
F
------------
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
D
-
K
H
D
-
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
A
Q
K
F
I
-------------------
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
----------
D
C
V
P
M
L
R
L
E
F
TG
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
FGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV--------------
1
PsiBlast_PDB
78.76
34%
-135
- C1 -
-
3DHW
-
METN_ECOLI
C:
[1-270]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
-
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
--
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
D
-
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
A
Q
K
F
I
Q------------------
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
----
L
Q
A
E
----------
P
F
T
D
C
V
P
M
L
R
--------------------------------------------------------------------------------
141
Fugue
77.41
27%
-91
- C1 -
-
1Z47
-
?
A:
[11-355]
-
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
----
G
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
----
K
G
D
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
K
---------------
R
N
V
G
L
V
------
F
Q
N
------------
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
--
V
-
P
K
-
D
E
M
D
A
R
V
R
E
L
L
R
F
-
M
R
L
E
S
-
Y
A
N
-
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
-
E
K
P
G
T
L
F
V
A
S
F
I
GE
S
N
V
W
T
R
A
V
Q
NG
R
I
E
V
AG
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
P
A
S
ER
E
A
H
A
Q
V
V
R
S
A
--
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
V
W
E
V
H
V
P
S
A
D
R
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R------------------------------
157
HHSearch
73.59
36%
-138
- C1 -
-
3DHW
-
METN_ECOLI
C:
[1-238]
----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
-
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
-
S
E
L
T
K
---------
A
R
R
Q
I
G
M
I
------
F
Q
H
F
N
------------
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
---
P
K
-
D
E
V
K
R
R
V
T
E
L
L
S
L
-
V
G
L
G
--
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-
S
H
P
K
T
P
L
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
70.84
33%
-115
- C1 -
-
2YYZ
1
?
A:
[2-238]
-
P
S
--
I
R
V
V
N
L
K
K
Y
F
G
-----
K
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
----
S
G
E
I
Y
F
D
D
V
L
V
N
D
I
P
P
K
---------------
Y
R
E
V
G
M
V
------
F
Q
N
-
Y
----------
A
-
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
-
L
R
A
R
R
I
S
K
----
D
E
V
E
K
R
V
V
E
I
A
R
K
-
L
L
I
D
--
N
L
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
-
D
S
P
K
N
M
F
V
A
S
F
I
-------------------
G
N
P
P
----------------------------------------------------------------------------------------------------------------------
161
HHSearch
70.57
33%
0
- C- -
-
4FWI
2
?
B:
[2-264]
--
S
I
I
I
R
V
E
D
L
R
A
V
Y
L
V
R
E
-
G
T
I
K
A
A
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
N
GRIL
S
G
R
V
L
Y
K
G
K
D
L
L
T
M
R
E
E
E
L
R
K
I
---------
R
W
K
E
I
A
L
V
------
P
Q
A
A
Q
----------
Q
S
L
N
P
T
M
K
V
I
E
H
F
K
D
T
-
V
E
A
H
G
V
R
W
-
S
H
-
S
E
L
I
E
K
A
S
E
K
L
R
M
-
V
R
L
N
P
E
A
V
L
N
S
Y
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
L
V
E
Y
N
S
T
F
Q
I
F
-
K
N
P
L
H
P
Y
T
R
G
L
----------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.26
35%
-112
- C1 -
-
2IT1
-
?
A:
[10-239]
----------------
V
K
K
F
G
N
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
----
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
P
P
K
D
---------------
R
N
V
G
L
V
------
F
Q
N
------------
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
K
A
P
R
----
E
E
I
D
K
K
V
R
E
V
A
K
M
-
L
H
I
D
--
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
-
Y
K
P
K
Y
K
F
V
G
G
F
L
-------------------
G
N
P
P
M
---------------------------------------------------------------------------------------------------------------------
142
Fugue
67.88
27%
-95
- C1 -
-
1OXS
-
?
C:
[1-352]
M
V
R
--
I
I
V
K
N
V
S
K
V
F
K
K
G
K
---
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
----
T
G
E
L
Y
F
D
D
R
L
V
A
S
-
N
G
K
L
I
V
P
P
---------
E
D
R
K
I
G
M
V
------
F
Q
T
W
------------
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
K
--
M
-
S
K
-
E
E
I
R
K
R
V
E
E
V
A
K
I
-
L
D
I
-
H
-
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
-
D
N
P
V
S
I
Q
V
A
S
L
I
-------------------
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
----------
P
V
S
V
S
S
D
R
A
I
I-
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
GGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
165
HHSearch
66.61
33%
-118
- C1 -
-
1Z47
-
?
B:
[14-243]
----
T
I
E
F
V
G
V
E
K
I
Y
P
G
----
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
----
K
G
D
V
W
I
G
G
K
R
V
T
D
L
------
P
P
---------
Q
K
R
N
V
G
L
V
------
F
Q
N
Y
A
------------
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
V
---
P
K
-
D
E
M
D
A
R
V
R
E
L
L
R
F
-
M
R
L
E
--
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
-
E
K
P
G
T
L
F
V
A
------------------------------------------------------------------------------------------------------------------------------------------------
166
HHSearch
66.27
35%
-113
- C1 -
-
2YYZ
1
?
A:
[2-226]
---
P
S
I
R
V
V
N
L
K
K
Y
F
G
-----
K
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
----
S
G
E
I
Y
F
D
D
V
L
V
N
D
I
------
P
P
---------
K
Y
R
E
V
G
M
V
------
F
Q
N
Y
A
------------
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
-
L
R
A
R
R
I
---
S
K
-
D
E
V
E
K
R
V
V
E
I
A
R
K
-
L
L
I
D
--
N
L
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
-
D
S
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
49.21
34%
-50
- C1 -
-
1VCI
1
?
A:
[27-251]
------------------------
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
----
E
G
R
I
Y
F
G
D
R
D
V
T
Y
L
P
P
K
D
---------------
R
N
I
S
M
V
------
F
Q
------------------
H
M
T
V
Y
E
N
I
A
F
P
-
L
--
K
K
F
P
K
-
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
-
E
E
L
L
-----
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
-
L
R
P
N
S
V
F
V
A
T
F
I
-------------------
G
A
------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
42.80
34%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
A:
[355-573]
---------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
----
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
----
L
A
S
---------
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
----------
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
-
I
E
E
A
A
R
M
A
-
Y
A
-
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
-
V
L
-------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
42.75
34%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
C:
[355-573]
---------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
----
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
----
L
A
S
---------
L
R
N
Q
V
A
L
V
SQNVHL
F
N
D
T
V
----------
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
-
I
E
E
A
A
R
M
A
-
Y
A
-
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
-
V
L
-------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
42.74
34%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
B:
[355-573]
---------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
----
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
----
L
A
S
---------
L
R
N
Q
V
A
L
V
SQNVHL
F
N
D
T
V
----------
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
-
I
E
E
A
A
R
M
A
-
Y
A
-
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
-
V
L
-------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
42.74
34%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
D:
[355-573]
---------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
----
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
----
L
A
S
---------
L
R
N
Q
V
A
L
V
SQNVHL
F
N
D
T
V
----------
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
-
I
E
E
A
A
R
M
A
-
Y
A
-
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
-
V
L
-------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
42.64
34%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
A:
[355-573]
---------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
----
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
----
L
A
S
---------
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
----------
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
-
I
E
E
A
A
R
M
A
-
Y
A
-
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
-
V
L
-------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
42.64
34%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
B:
[355-573]
---------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
----
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
----
L
A
S
---------
L
R
N
Q
V
A
L
V
SQNVHL
F
N
D
T
V
----------
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
-
I
E
E
A
A
R
M
A
-
Y
A
-
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
-
V
L
-------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
42.64
34%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
C:
[355-573]
---------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
----
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
----
L
A
S
---------
L
R
N
Q
V
A
L
V
SQNVHL
F
N
D
T
V
----------
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
-
I
E
E
A
A
R
M
A
-
Y
A
-
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
-
V
L
-------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
42.62
34%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
D:
[355-573]
---------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
----
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
----
L
A
S
---------
L
R
N
Q
V
A
L
V
SQNVHL
F
N
D
T
V
----------
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
-
I
E
E
A
A
R
M
A
-
Y
A
-
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
-
V
L
-------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
42.38
33%
-5
- C1 -
-
1B0U
1
HISP_SALTY
A:
[45-253]
------------------------------------------------
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
----
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
K
D
G
Q
L
K
VAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
------
F
Q
--
H
----------
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
L
S
K
H
D
A
-
R
E
R
A
L
K
Y
---
L
A
K
-
V
G
I
D
E
-
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
-
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
-
G
N
P
Q
S
P
R
L
Q
Q
F
L
---------------------------------------------------------------------------------------------------------------------------------------------
133
PsiBlast_CBE
37.84
34%
-12
- C1 -
-
2FGJ
2
HLYBP_ECOLX
B:
[25-230]
-------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
----
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
------------
R
R
Q
V
G
V
V
------
L
Q
D
N
V
LLNRSIIDNI
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
-
I
S
-
E
L
R
E
-----------
G
Y
N
T
-
I
V
G
E
Q
G
A
G
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
131
PsiBlast_CBE
37.55
34%
-10
- C1 -
-
2FGJ
2
D:
[25-230]
-------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
----
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
------------
R
R
Q
V
G
V
V
------
L
Q
D
N
V
LLNRSIIDNI
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
-
I
S
-
E
L
R
E
-----------
G
Y
N
T
-
I
V
G
E
Q
G
A
G
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
125
PsiBlast_CBE
36.37
34%
-5
- C1 -
-
2FGK
2
HLYBP_ECOLX
A:
[25-230]
-------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
----
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
------------
R
R
Q
V
G
V
V
------
L
Q
D
N
V
LLNRS
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
-
I
S
-
E
L
R
E
-----------
G
Y
N
T
-
I
V
G
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
137
PsiBlast_CBE
36.13
34%
-14
- C1 -
-
1XEF
2
HLYBP_ECOLX
C:
[19-224]
-------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
----
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
------------
R
R
Q
V
G
V
V
------
L
Q
D
N
V
LLNRSIIDNI
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
-
I
S
-
E
L
R
E
-----------
G
Y
N
T
-
I
V
G
E
Q
G
A
G
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
138
PsiBlast_CBE
35.73
34%
-12
- C1 -
-
1XEF
2
HLYBP_ECOLX
B:
[19-224]
-------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
----
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
------------
R
R
Q
V
G
V
V
------
L
Q
D
N
V
LLNRSIIDNI
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
-
I
S
-
E
L
R
E
-----------
G
Y
N
T
-
I
V
G
E
Q
G
A
G
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
136
PsiBlast_CBE
35.68
34%
-10
- C1 -
-
1XEF
2
D:
[19-224]
-------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
----
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
------------
R
R
Q
V
G
V
V
------
L
Q
D
N
V
LLNRSIIDNI
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
-
I
S
-
E
L
R
E
-----------
G
Y
N
T
-
I
V
G
E
Q
G
A
G
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
134
PsiBlast_CBE
35.32
34%
-17
- C1 -
-
2FGJ
2
HLYBP_ECOLX
A:
[25-230]
-------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
----
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
------------
R
R
Q
V
G
V
V
------
L
Q
D
N
V
L
L
NRS
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
-
I
S
-
E
L
R
E
-----------
G
Y
N
T
-
I
V
G
E
Q
G
A
G
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
124
PsiBlast_CBE
32.28
34%
-9
- C1 -
-
2FGK
2
HLYBP_ECOLX
B:
[25-230]
-------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
----
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
------------
R
R
Q
V
G
V
V
------
L
Q
D
N
V
LLNRSIIDNI
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
-
I
S
-
E
L
R
E
-----------
G
Y
N
T
-
I
V
G
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
116
PsiBlast_CBE
31.51
34%
-9
- C1 -
-
2PMK
1
A:
[21-226]
-------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
----
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
------------
R
R
Q
V
G
V
V
------
L
Q
D
N
V
LLNRS
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
-
I
S
-
E
L
R
E
-----------
G
Y
N
T
-
I
V
G
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
123
PsiBlast_CBE
30.84
34%
-4
- C1 -
-
2FGK
2
HLYBP_ECOLX
C:
[25-230]
-------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
----
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
------------
R
R
Q
V
G
V
V
------
L
Q
D
N
V
LLNRSIIDNI
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
-
I
S
-
E
L
R
E
-----------
G
Y
N
T
-
I
V
G
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
122
PsiBlast_CBE
30.31
34%
-9
- C1 -
-
2FGK
2
D:
[25-230]
-------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
----
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
------------
R
R
Q
V
G
V
V
------
L
Q
D
N
V
LLNRSIIDNI
S
L
A
N
P
G
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
-
I
S
-
E
L
R
E
-----------
G
Y
N
T
-
I
V
G
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------