@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXC6: (2018-01-03 )
MLINEQLVKRVITPRPKISHKGTFGRIVLIGGNEQYGGAIIMSALAAVHSGAGLTTVVTDEKNRSALHSHLPEAMIVVWTDTDQFLSVIKQADVLLIGPGLGTSSKSLERFKQVLENQSKEQWLVIDGSALSLLAANHLLLPYPEQTVLTPHQMEWQRLSSLPIQEQRDKENKKKQQEIGAVLVLKSHETKIYGHQHFYTNPLGSAAMATGGMGDTLAGMITGFLAQFPQNDQTIAAAIYLHSFIGDQLAKEQYIVLPTQISEALPKWMNYFCKKSMENEA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80.---------.----------.-.....90........100.......110.......120.......130......-.--140.........150.......160...---....170....--...180.........190...-....200.......210.......220.......-230-.......240.......250-........260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
ML
I
N
E
Q
L
V
K
R
VITPRPKISHKGTF
G
R
I
V
L
IGGNEQY
G
G
A
I
I
M
S
A
L
A
A
V
HSGA
G
L
T
T
V
V
TDEK
N
R
S
A
L
H
S
HLP
E
A
M
I
V
V
WTD
T
---------
D
----------
Q
-
F
L
S
V
I
K
QA
D
V
L
L
IGPGLGT
S
S
K
S
L
E
R
F
K
Q
V
L
ENQSKE
Q
W
L
V
IDG
S
A
L
S
L
L
A
ANH-L--L--LPYPEQTVLTP
H
Q
M
E
W
Q
R
L
SSLP
I
Q
---
E
Q
R
D
KE
N
K
K
K
Q
--
Q
EI
G
--
A
V
L
V
L
KSH
E
T
K
I
YGH-
Q
H
FYTNPLG
S
A
A
MATGGM
G
D
T
L
A
G
M
I
T
G
F
L
A
QFP-QND-
Q
T
I
A
A
A
I
Y
L
H
S
F
I
G
D
Q
L
AK--E
Q
Y
I
V
L
P
T
Q
I
S
E
A
L
P
K
W
M
N
Y
F
C
K
K
SMENEA
1
PsiBlast_PDB
98.84
51%
-125
- C1 -
-
2R3B
4
NNRD_ENTFA
A:
[23-294]
--
L
S
K
D
I
L
E
E
V
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
M
V
V
G
F
E
E
T
---------
V
----------
L
-
L
T
N
V
V
E
Q
A
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
M
V
L
A
Q
H
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
-
F
--
S
--
L
T
Y
P
E
K
V
V
F
T
P
H
Q
M
E
W
Q
R
L
S
H
L
P
I
E
---
Q
Q
T
L
A
N
N
Q
R
Q
Q
--
A
K
L
G
--
S
T
I
V
L
K
S
H
R
T
T
I
F
H
A
-
G
E
P
F
Q
N
T
G
G
N
P
G
M
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
F
K
-
P
T
I
-
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
--
T
D
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
M
K
K
Y
A
Q
-------
2
PsiBlast_PDB
97.76
51%
-125
- C1 -
-
2R3E
2
NNRD_ENTFA
A:
[23-294]
--
L
S
K
D
I
L
E
E
V
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
M
V
V
G
F
E
E
T
---------
V
----------
L
-
L
T
N
V
V
E
Q
A
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
M
V
L
A
Q
H
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
-
F
--
S
--
L
T
Y
P
E
K
V
V
F
T
P
H
Q
M
E
W
Q
R
L
S
H
L
P
I
E
---
Q
Q
T
L
A
N
N
Q
R
Q
Q
--
A
K
L
G
--
S
T
I
V
L
K
S
H
R
T
T
I
F
H
A
-
G
E
P
F
Q
N
T
G
G
N
P
G
M
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
F
K
-
P
T
I
-
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
--
T
D
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
M
K
K
Y
A
Q
-------
22
HHSearch
92.82
53%
-78
- C1 -
-
2R3B
4
NNRD_ENTFA
A:
[24-295]
---
S
K
D
I
L
E
E
V
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
M
V
V
G
F
E
E
T
---------
V
----------
L
-
L
T
N
V
V
E
Q
A
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
M
V
L
A
Q
H
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
-
F
--
S
LT
Y
P
--
E
K
V
V
F
T
P
H
Q
M
E
W
Q
R
L
S
H
L
P
I
E
---
Q
Q
T
L
A
N
N
Q
R
Q
Q
--
A
K
L
G
--
S
T
I
V
L
K
S
H
R
T
T
I
F
H
A
-
G
E
P
F
Q
N
T
G
G
N
P
G
M
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
F
K
-
P
T
I
-
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
--
T
D
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
M
K
K
Y
A
Q
P
------
23
HHSearch
91.51
53%
-79
- C1 -
-
2R3B
6
NNRD_ENTFA
B:
[24-295]
---
S
K
D
I
L
E
E
V
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
M
V
V
G
F
E
E
T
---------
V
----------
L
-
L
T
N
V
V
E
Q
A
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
M
V
L
A
Q
H
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
-
F
--
S
LT
Y
P
--
E
K
V
V
F
T
P
H
Q
M
E
W
Q
R
L
S
H
L
P
I
E
---
Q
Q
T
L
A
N
N
Q
R
Q
Q
--
A
K
L
G
--
S
T
I
V
L
K
S
H
R
T
T
I
F
H
A
-
G
E
P
F
Q
N
T
G
G
N
P
G
M
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
F
K
-
P
T
I
-
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
--
T
D
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
M
K
K
Y
A
Q
P
------
3
PsiBlast_PDB
87.01
48%
-106
- C1 -
-
3BGK
-
?
A:
[36-304]
-
I
I
D
D
L
L
T
K
K
I
I
K
P
R
P
L
N
S
H
K
G
T
F
G
R
V
L
L
I
G
G
N
Y
P
Y
G
G
A
I
I
M
A
A
L
A
C
V
N
S
G
A
G
L
V
T
V
A
T
H
K
D
N
I
T
A
L
H
S
H
L
P
E
A
M
A
F
D
M
V
E
K
---------
D
----------
R
-
L
S
E
Q
I
T
A
A
D
V
V
L
M
G
P
G
L
A
E
D
D
L
A
Q
T
T
F
D
V
V
W
Q
A
I
E
P
K
Q
T
L
I
I
D
G
S
A
I
N
L
L
A
K
R
K
----
A
--
I
W
P
T
K
Q
I
I
L
T
P
H
Q
K
E
W
E
R
L
S
G
L
T
I
P
---
E
Q
I
E
A
A
T
Q
T
A
L
--
A
H
F
P
KE
T
I
L
V
A
K
S
H
Q
T
K
I
Y
Q
G
-
Q
K
I
G
H
I
Q
V
G
G
P
Y
Q
A
T
G
G
M
G
D
T
L
A
G
M
I
A
G
F
V
A
Q
F
H
-
T
D
R
F
E
V
A
A
A
A
V
F
L
H
S
Y
I
A
D
Q
L
S
K
--
E
A
Y
V
V
L
P
T
R
I
S
A
E
I
T
R
--------------
21
HHSearch
83.06
50%
-67
* C1 *
-
3BGK
-
?
A:
[38-311]
---
D
D
L
L
T
K
K
I
I
K
P
R
P
L
N
S
H
K
G
T
F
G
R
V
L
L
I
G
G
N
Y
P
Y
G
G
A
I
I
M
A
A
L
A
C
V
N
S
G
A
G
L
V
T
V
A
T
H
K
D
N
I
T
A
L
H
S
H
L
P
E
A
M
A
F
D
M
V
E
K
---------
D
----------
R
-
L
S
E
Q
I
T
A
A
D
V
V
L
M
G
P
G
L
A
E
D
D
L
A
Q
T
T
F
D
V
V
W
Q
A
I
E
P
K
Q
T
L
I
I
D
G
S
A
I
N
L
L
A
K
R
K
--AI
W
--
P
T
--
K
Q
I
I
L
T
P
H
Q
K
E
W
E
R
L
S
G
L
T
I
P
EQI
E
A
A
T
Q
T
A
L
A
H
F
--
P
-
K
E
--
T
I
L
V
A
K
S
H
Q
T
K
I
Y
Q
G
-
Q
K
I
G
H
I
Q
V
G
G
P
Y
Q
A
T
G
G
M
G
D
T
L
A
G
M
I
A
G
F
V
A
Q
F
H
T
D
R
F
-
E
V
A
A
A
A
V
F
L
H
S
Y
I
A
D
Q
L
S
K
--
E
A
Y
V
V
L
P
T
R
I
S
A
E
I
T
R
V
M
K
E
M
S
E
-------
25
HHSearch
62.65
28%
-55
- C1 -
-
3RPZ
2
NNRD_BACSU
A:
[10-278]
---
T
E
E
H
V
R
A
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
W
R
D
G
W
K
---------
K
----------
A
A
D
A
Q
L
E
E
T
Y
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
---
A
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
---
P
--
K
--
R
E
--
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
--
A
Q
L
Q
--
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
-
D
P
K
-
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
EH
S
A
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
W
K
R
F
---------
24
HHSearch
62.61
28%
-58
- C1 -
-
3RQH
2
NNRD_BACSU
A:
[10-278]
---
T
E
E
H
V
R
A
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
W
R
D
G
W
K
---------
K
----------
A
A
D
A
Q
L
E
E
T
Y
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
---
A
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
---
P
--
K
--
R
E
--
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
--
A
Q
L
Q
--
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
-
D
P
K
-
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
EH
S
A
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
W
K
R
F
---------
10
PsiBlast_PDB
61.63
28%
2
- C1 -
-
3RT9
3
NNR_THEMA
A:
[222-497]
-
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
-
L
I
S
V
P
I
D
T
---------
E
KGFFSLQN
L
Q
E
-
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
--
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
--
V
--
L
--
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
---
D
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
--
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
-
S
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
--
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
------------
14
PsiBlast_PDB
60.44
28%
4
- C1 -
-
3RTE
2
NNR_THEMA
A:
[222-497]
-
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
-
L
I
S
V
P
I
D
T
---------
E
KGFFSLQN
L
Q
E
-
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
--
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
--
V
--
L
--
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
---
D
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
--
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
-
S
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
--
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
------------
6
PsiBlast_PDB
60.44
28%
0
- C1 -
-
3RSF
-
NNR_THEMA
A:
[222-497]
-
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
-
L
I
S
V
P
I
D
T
---------
E
KGFFSLQN
L
Q
E
-
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
--
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
--
V
--
L
--
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
---
D
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
--
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
-
S
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
--
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
------------
28
HHSearch
60.26
28%
-5
- C1 -
-
3RTA
1
NNR_THEMA
A:
[224-501]
---
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
KGFFSLQN
L
Q
----------
E
-
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
--
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
K
--
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
DV-
K
Y
N
Y
E
L
A
E
E
F
A
--
K
E
N
D
--
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
-
S
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
--
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
20
PsiBlast_PDB
60.16
28%
1
- C1 -
-
3RRJ
-
NNR_THEMA
A:
[222-497]
-
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
-
L
I
S
V
P
I
D
T
---------
E
KGFFSLQN
L
Q
E
-
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
--
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
--
V
--
L
--
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
---
D
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
--
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
-
S
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
--
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
------------
11
PsiBlast_PDB
60.05
28%
1
- C1 -
-
3RTA
1
NNR_THEMA
A:
[222-497]
-
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
-
L
I
S
V
P
I
D
T
---------
E
KGFFSLQN
L
Q
E
-
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
--
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
--
V
--
L
--
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
---
D
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
--
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
-
S
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
--
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
------------
27
HHSearch
60.01
28%
-8
- C1 -
-
3RSS
-
NNR_THEMA
A:
[224-501]
---
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
KGFFSLQN
L
Q
----------
E
-
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
--
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
K
--
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
DV-
K
Y
N
Y
E
L
A
E
E
F
A
--
K
E
N
D
--
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
-
S
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
--
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
15
PsiBlast_PDB
59.87
28%
2
- C1 -
-
3RTG
3
NNR_THEMA
A:
[222-497]
-
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
-
L
I
S
V
P
I
D
T
---------
E
KGFFSLQN
L
Q
E
-
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
--
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
--
V
--
L
--
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
---
D
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
--
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
-
S
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
--
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
------------
4
PsiBlast_PDB
59.86
28%
3
- C1 -
-
3RS8
3
NNR_THEMA
A:
[222-497]
-
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
-
L
I
S
V
P
I
D
T
---------
E
KGFFSLQN
L
Q
E
-
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
--
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
--
V
--
L
--
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
---
D
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
--
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
-
S
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
--
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
------------
18
PsiBlast_PDB
59.79
28%
3
- C1 -
-
3RRE
2
NNR_THEMA
A:
[222-497]
-
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
-
L
I
S
V
P
I
D
T
---------
E
KGFFSLQN
L
Q
E
-
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
--
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
--
V
--
L
--
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
---
D
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
--
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
-
S
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
--
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
------------
5
PsiBlast_PDB
59.78
28%
2
- C1 -
-
3RS9
1
NNR_THEMA
A:
[222-497]
-
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
-
L
I
S
V
P
I
D
T
---------
E
KGFFSLQN
L
Q
E
-
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
--
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
--
V
--
L
--
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
---
D
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
--
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
-
S
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
--
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
------------
16
PsiBlast_PDB
59.76
28%
-0
- C1 -
-
3RU3
2
NNR_THEMA
A:
[222-497]
-
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
-
L
I
S
V
P
I
D
T
---------
E
KGFFSLQN
L
Q
E
-
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
--
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
--
V
--
L
--
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
---
D
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
--
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
-
S
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
--
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
------------