@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXF9: (2018-01-03 )
MITMDDIIREGNPTLREVAKEVSLPLSEEDISLGKEMLEFLKNSQDPIKAEELHLRGGVGLAAPQLDISKRIIAVHVPSPDPEADGPSLSTVMYNPKILSHSVQDACLGEGEGCLSVDREVPGYVVRHAKITVSYYDMNGEKHKIRLKNYESIVVQHEIDHINGVMFYDHINDQNPFALKEGVLVIE
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70........-----80......----.----.-90........100...-....110.......120........130.......140.......150.......160.......170.......180.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MI
T
M
D
D
I
I
REGN
P
T
L
R
E
V
A
K
E
VSLPLS
E
E
D
I
S
L
G
K
E
M
L
E
F
L
KNSQDPIK
A
E
E
L
H
LRGGVGLAAPQLDIS
K
R
I
I
A
V
HVPS-----PDPEADGP----S----
L
-
S
T
V
M
YN
P
K
I
L
S
HS
V
Q
D
-
A
CLGEGEG
C
L
S
VDRE-VP
G
Y
V
V
R
H
A
K
I
T
V
S
Y
Y
DMNGE
K
H
K
I
R
LKNY
E
S
I
V
V
Q
H
EIDHIN
G
V
M
F
Y
DHINDQNPFALKE
G
V
L
V
IE
1
PsiBlast_PDB
98.27
100%
-115
- C4 -
-
3G6N
-
?
A:
[5-191]
M
I
T
M
D
D
I
I
R
E
G
N
P
T
L
R
E
V
A
K
E
V
S
L
P
L
S
E
E
D
I
S
L
G
K
E
M
L
E
F
L
K
N
S
Q
D
P
I
K
A
E
E
L
H
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
H
V
P
S
-----------------
S
----
L
-
S
T
V
M
Y
N
P
K
I
L
S
H
S
V
Q
D
-
A
C
L
G
E
G
E
G
C
L
S
V
D
R
E
-
V
P
G
Y
V
V
R
H
A
K
I
T
V
S
Y
Y
D
M
N
G
E
K
H
K
I
R
L
K
N
Y
E
S
I
V
V
Q
H
E
I
D
H
I
N
G
V
M
F
Y
D
H
I
N
D
Q
N
P
F
A
L
K
E
G
V
L
V
I
E
2
PsiBlast_PDB
97.63
100%
-112
- C4 -
-
3CMD
-
?
A:
[10-196]
M
I
T
M
D
D
I
I
R
E
G
N
P
T
L
R
E
V
A
K
E
V
S
L
P
L
S
E
E
D
I
S
L
G
K
E
M
L
E
F
L
K
N
S
Q
D
P
I
K
A
E
E
L
H
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
H
V
P
S
-----------------
S
----
L
-
S
T
V
M
Y
N
P
K
I
L
S
H
S
V
Q
D
-
A
C
L
G
E
G
E
G
C
L
S
V
D
R
E
-
V
P
G
Y
V
V
R
H
A
K
I
T
V
S
Y
Y
D
M
N
G
E
K
H
K
I
R
L
K
N
Y
E
S
I
V
V
Q
H
E
I
D
H
I
N
G
V
M
F
Y
D
H
I
N
D
Q
N
P
F
A
L
K
E
G
V
L
V
I
E
3
PsiBlast_PDB
94.59
85%
-113
- C4 -
-
2OS1
1
DEF_ENTFA
A:
[1-187]
M
I
T
M
K
D
I
I
R
E
G
N
P
T
L
R
A
V
A
E
E
V
P
V
P
I
T
E
E
D
R
Q
L
G
E
D
M
L
T
F
L
K
N
S
Q
D
P
V
K
A
E
E
L
Q
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
H
V
P
------------------
S
----
L
-
S
T
V
M
Y
N
P
K
I
L
S
H
S
V
Q
D
-
V
C
L
G
E
G
E
G
C
L
S
V
D
R
D
-
V
P
G
Y
V
V
R
H
N
K
I
T
V
S
Y
F
D
M
A
G
E
K
H
K
V
R
L
K
N
Y
E
A
I
V
V
Q
H
E
I
D
H
I
N
G
I
M
F
Y
D
H
I
N
K
E
N
P
F
A
L
K
E
G
V
L
V
I
E
4
PsiBlast_PDB
93.84
84%
-112
- C4 -
-
2OS0
-
DEF_ENTFA
A:
[1-187]
M
I
T
M
K
D
I
I
R
E
G
N
P
T
L
R
A
V
A
E
E
V
P
V
P
I
T
E
E
D
R
Q
L
G
E
D
M
L
T
F
L
K
N
S
Q
D
P
V
K
A
E
E
L
Q
L
R
G
D
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
H
V
P
------------------
S
----
L
-
S
T
V
M
Y
N
P
K
I
L
S
H
S
V
Q
D
-
V
C
L
G
E
G
E
G
C
L
S
V
D
R
D
-
V
P
G
Y
V
V
R
H
N
K
I
T
V
S
Y
F
D
M
A
G
E
K
H
K
V
R
L
K
N
Y
E
A
I
V
V
Q
H
E
I
D
H
I
N
G
I
M
F
Y
D
H
I
N
K
E
N
P
F
A
L
K
E
G
V
L
V
I
E
119
HHSearch
91.14
98%
-51
- C4 -
-
3CMD
-
?
B:
[10-196]
M
I
T
M
D
D
I
I
R
E
G
N
P
T
L
R
E
V
A
K
E
V
S
L
P
L
S
E
E
D
I
S
L
G
K
E
M
L
E
F
L
K
N
S
Q
D
P
I
K
A
E
E
L
H
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
H
V
P
S
-----------------
S
----
L
-
S
T
V
M
Y
N
P
K
I
L
S
H
S
V
Q
D
A
C
L
-
G
E
G
E
G
C
L
S
V
D
-
R
E
V
P
G
Y
V
V
R
H
A
K
I
T
V
S
Y
Y
D
M
N
G
E
K
H
K
I
R
L
K
N
Y
E
S
I
V
V
Q
H
E
I
D
H
I
N
G
V
M
F
Y
D
H
I
N
D
Q
N
P
F
A
L
K
E
G
V
L
V
I
E
118
HHSearch
86.64
84%
-37
- C4 -
-
2OS0
-
DEF_ENTFA
A:
[1-187]
M
I
T
M
K
D
I
I
R
E
G
N
P
T
L
R
A
V
A
E
E
V
P
V
P
I
T
E
E
D
R
Q
L
G
E
D
M
L
T
F
L
K
N
S
Q
D
P
V
K
A
E
E
L
Q
L
R
G
D
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
H
V
P
------------------
S
----
L
-
S
T
V
M
Y
N
P
K
I
L
S
H
S
V
Q
D
V
C
L
-
G
E
G
E
G
C
L
S
V
D
-
R
D
V
P
G
Y
V
V
R
H
N
K
I
T
V
S
Y
F
D
M
A
G
E
K
H
K
V
R
L
K
N
Y
E
A
I
V
V
Q
H
E
I
D
H
I
N
G
I
M
F
Y
D
H
I
N
K
E
N
P
F
A
L
K
E
G
V
L
V
I
E
23
PsiBlast_CBE
86.20
68%
-33
- C4 -
-
2OS3
1
DEF_STRP1
A:
[12-203]
L
I
T
M
D
D
I
I
R
E
G
N
P
T
L
R
A
V
A
K
E
V
S
L
P
L
C
D
E
D
I
L
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
V
M
A
E
K
L
G
L
R
A
G
V
G
L
A
A
P
Q
I
D
V
S
K
R
I
I
A
V
L
V
P
N
L
----
P
D
K
E
G
N
P
P
KEAY
S
----
W
-
Q
E
V
L
Y
N
P
K
I
V
S
H
S
V
Q
D
-
A
A
L
S
D
G
E
G
C
L
S
V
D
R
V
-
V
E
G
Y
V
V
R
H
A
R
V
T
V
D
Y
Y
D
K
E
G
Q
Q
H
R
I
K
L
K
G
Y
N
A
I
V
V
Q
H
E
I
D
H
I
N
G
V
L
F
Y
D
R
I
N
A
K
N
P
F
E
T
K
E
E
L
L
I
L
D
16
PsiBlast_PDB
84.12
67%
-27
- C4 -
-
5JF5
2
DEF_STRA3
A:
[13-204]
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
AQ
G
N
P
P
K
E
A
Y
----
S
----
L
-
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
26
PsiBlast_CBE
84.04
54%
-102
- C4 -
-
1LQY
1
DEF2_GEOSE
A:
[1-182]
M
I
T
M
K
D
I
I
K
E
G
H
P
T
L
R
K
V
A
E
P
V
P
L
P
P
S
E
E
D
K
R
I
L
Q
S
L
L
D
Y
V
K
M
S
Q
D
P
E
L
A
A
K
Y
G
L
R
P
G
I
G
L
A
A
P
Q
I
N
V
S
K
R
M
I
A
V
H
V
T
---------
D
E
N
G
T
----
L
----
Y
-
S
Y
A
L
F
N
P
K
I
V
S
H
S
V
Q
Q
-
C
Y
L
T
T
G
E
G
C
L
S
V
D
R
D
-
V
P
G
Y
V
L
R
Y
A
R
I
T
V
T
G
T
T
L
D
G
E
E
V
T
L
R
L
K
G
L
P
A
I
V
F
Q
H
E
I
D
H
L
N
G
I
M
F
Y
D
R
I
N
P
A
D
P
F
Q
V
P
D
G
A
I
P
I
-
9
PsiBlast_PDB
83.94
67%
-24
- C4 -
-
5JEX
1
DEF_STRA3
A:
[13-204]
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
AQ
G
N
P
P
K
E
A
Y
----
S
----
L
-
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
12
PsiBlast_PDB
83.20
67%
-25
- C4 -
-
5JF1
1
DEF_STRA3
A:
[13-204]
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
AQ
G
N
P
P
K
E
A
Y
----
S
----
L
-
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
24
PsiBlast_CBE
83.15
62%
-97
- C4 -
-
2OKL
3
DEF2_BACCR
B:
[2-175]
M
L
T
M
K
D
V
I
R
E
G
D
P
I
L
R
N
V
A
E
E
V
S
L
P
A
S
E
E
D
T
T
T
L
K
E
M
I
E
F
V
I
N
S
Q
D
P
E
M
A
E
K
Y
S
L
R
P
G
I
G
L
A
A
P
Q
I
G
V
S
K
K
M
I
A
V
H
V
T
---------
D
A
D
G
T
----
L
----
Y
-
S
H
A
L
F
N
P
K
I
I
S
H
S
V
E
R
-
T
Y
L
Q
G
G
E
G
C
L
S
V
D
R
E
-
V
P
G
Y
V
P
R
Y
T
R
I
T
V
K
A
T
S
I
N
G
E
E
V
K
L
R
L
K
G
L
P
A
I
V
F
Q
H
E
I
D
H
L
N
G
V
M
F
Y
D
H
I
N
K
E
N
P
F
A
---------
14
PsiBlast_PDB
83.14
67%
-23
- C4 -
-
5JF3
2
DEF_STRA3
A:
[13-204]
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
AQ
G
N
P
P
K
E
A
Y
----
S
----
L
-
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
13
PsiBlast_PDB
82.91
67%
-24
- C4 -
-
5JF2
2
DEF_STRA3
A:
[13-204]
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
AQ
G
N
P
P
K
E
A
Y
----
S
----
L
-
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
15
PsiBlast_PDB
82.90
67%
-25
- C4 -
-
5JF4
2
DEF_STRA3
A:
[13-204]
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
AQ
G
N
P
P
K
E
A
Y
----
S
----
L
-
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
25
PsiBlast_CBE
82.57
62%
-91
- C4 -
-
2OKL
4
DEF2_BACCR
A:
[2-175]
M
L
T
M
K
D
V
I
R
E
G
D
P
I
L
R
N
V
A
E
E
V
S
L
P
A
S
E
E
D
T
T
T
L
K
E
M
I
E
F
V
I
N
S
Q
D
P
E
M
A
E
K
Y
S
L
R
P
G
I
G
L
A
A
P
Q
I
G
V
S
K
K
M
I
A
V
H
V
T
---------
D
A
D
G
T
----
L
----
Y
-
S
H
A
L
F
N
P
K
I
I
S
H
S
V
E
R
-
T
Y
L
Q
G
G
E
G
C
L
S
V
D
R
E
-
V
P
G
Y
V
P
R
Y
T
R
I
T
V
K
A
T
S
I
N
G
E
E
V
K
L
R
L
K
G
L
P
A
I
V
F
Q
H
E
I
D
H
L
N
G
V
M
F
Y
D
H
I
N
K
E
N
P
F
A
---------
17
PsiBlast_PDB
82.54
67%
-22
- C4 -
-
5JF6
1
DEF_STRA3
A:
[13-204]
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
AQ
G
N
P
P
K
E
A
Y
----
S
----
L
-
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
19
PsiBlast_PDB
82.37
67%
-23
- C4 -
-
5JF8
2
DEF_STRA3
A:
[13-204]
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
AQ
G
N
P
P
K
E
A
Y
----
S
----
L
-
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
20
PsiBlast_PDB
82.28
67%
-21
- C4 -
-
5JF0
-
DEF_STRA3
A:
[13-204]
L
I
D
-
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
AQ
G
N
P
P
K
E
A
Y
----
S
----
L
-
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
8
PsiBlast_PDB
82.04
68%
-36
- C4 -
-
2AIA
1
DEF_STRR6
A:
[13-203]
L
I
D
M
C
D
I
I
R
E
G
N
P
S
L
R
T
V
A
E
E
V
T
F
P
L
S
D
Q
E
I
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
V
M
A
E
K
M
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
------------------AYD-
L
-
E
A
I
M
Y
N
P
K
I
V
S
H
S
V
Q
D
-
A
A
L
G
E
G
E
G
C
L
S
V
D
R
N
-
V
P
G
Y
V
V
R
H
A
R
V
T
V
D
Y
F
D
K
D
G
E
K
H
R
I
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
N
G
I
M
F
Y
D
R
I
N
E
K
D
P
F
A
V
K
D
G
L
L
I
L
E
18
PsiBlast_PDB
80.93
67%
-22
- C4 -
-
5JF7
2
DEF_STRA3
A:
[13-204]
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
AQ
G
N
P
P
K
E
A
Y
----
S
----
L
-
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
7
PsiBlast_PDB
79.74
68%
-9
- C4 -
-
2AI7
1
DEF_STRR6
A:
[13-203]
L
I
D
M
C
D
I
I
R
E
G
N
P
S
L
R
T
V
A
E
E
V
T
F
P
L
S
D
Q
E
I
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
V
M
A
E
K
M
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
-----
I
------------EAYD
L
-
E
A
I
M
Y
N
P
K
I
V
S
H
S
V
Q
D
-
A
A
L
G
E
G
E
G
C
L
S
V
D
R
N
-
V
P
G
Y
V
V
R
H
A
R
V
T
V
D
Y
F
D
K
D
G
E
K
H
R
I
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
N
G
I
M
F
Y
D
R
I
N
E
K
D
P
F
A
V
K
D
G
L
L
I
L
E
6
PsiBlast_PDB
79.68
68%
-8
- C4 -
-
2AIE
1
DEF_STRR6
P:
[13-203]
L
I
D
M
C
D
I
I
R
E
G
N
P
S
L
R
T
V
A
E
E
V
T
F
P
L
S
D
Q
E
I
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
V
M
A
E
K
M
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
-----
I
------------EAYD
L
-
E
A
I
M
Y
N
P
K
I
V
S
H
S
V
Q
D
-
A
A
L
G
E
G
E
G
C
L
S
V
D
R
N
-
V
P
G
Y
V
V
R
H
A
R
V
T
V
D
Y
F
D
K
D
G
E
K
H
R
I
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
N
G
I
M
F
Y
D
R
I
N
E
K
D
P
F
A
V
K
D
G
L
L
I
L
E
5
PsiBlast_PDB
79.68
68%
-9
- C4 -
-
3SW8
1
?
P:
[13-203]
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
T
V
A
E
E
V
T
F
P
L
S
D
Q
E
I
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
V
M
A
E
K
M
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
-----
I
------------EAYD
L
-
E
A
I
M
Y
N
P
K
I
V
S
H
S
V
Q
D
-
A
A
L
G
E
G
E
G
C
L
S
V
D
R
N
-
V
P
G
Y
V
V
R
H
A
R
V
T
V
D
Y
F
D
K
D
G
E
K
H
R
I
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
N
G
I
M
F
Y
D
R
I
N
E
K
D
P
F
A
V
K
D
G
L
L
I
L
E
121
HHSearch
77.86
60%
-50
- C4 -
-
2OKL
3
DEF2_BACCR
B:
[2-179]
M
L
T
M
K
D
V
I
R
E
G
D
P
I
L
R
N
V
A
E
E
V
S
L
P
A
S
E
E
D
T
T
T
L
K
E
M
I
E
F
V
I
N
S
Q
D
P
E
M
A
E
K
Y
S
L
R
P
G
I
G
L
A
A
P
Q
I
G
V
S
K
K
M
I
A
V
H
V
T
D
-----
A
D
G
----
T
----
L
----
Y
-
S
H
A
L
F
N
P
K
I
I
S
H
S
V
E
R
-
T
Y
L
Q
G
G
E
G
C
L
S
V
D
-
R
E
V
P
G
Y
V
P
R
Y
T
R
I
T
V
K
A
T
S
I
N
G
E
E
V
K
L
R
L
K
G
L
P
A
I
V
F
Q
H
E
I
D
H
L
N
G
V
M
F
Y
D
H
I
N
K
E
N
P
F
A
A
P
D
D
-----
120
HHSearch
77.76
55%
-48
- C4 -
-
1LQY
1
DEF2_GEOSE
A:
[1-180]
M
I
T
M
K
D
I
I
K
E
G
H
P
T
L
R
K
V
A
E
P
V
P
L
P
P
S
E
E
D
K
R
I
L
Q
S
L
L
D
Y
V
K
M
S
Q
D
P
E
L
A
A
K
Y
G
L
R
P
G
I
G
L
A
A
P
Q
I
N
V
S
K
R
M
I
A
V
H
V
T
D
-----
E
N
G
----
T
----
L
----
Y
-
S
Y
A
L
F
N
P
K
I
V
S
H
S
V
Q
Q
C
Y
L
-
T
T
G
E
G
C
L
S
V
D
-
R
D
V
P
G
Y
V
L
R
Y
A
R
I
T
V
T
G
T
T
L
D
G
E
E
V
T
L
R
L
K
G
L
P
A
I
V
F
Q
H
E
I
D
H
L
N
G
I
M
F
Y
D
R
I
N
P
A
D
P
F
Q
V
P
D
G
A
I
---
35
PsiBlast_CBE
63.10
31%
-42
- C4 -
-
1VEY
1
DEF_LEPIN
B:
[5-167]
------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
Q
T
-
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
-----
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
-----
N
E
R
Y
P
G
T
P
----
D
----
V
P
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
------
40
PsiBlast_CBE
62.52
31%
-48
- C4 -
-
1SV2
1
DEF_LEPIN
A:
[5-167]
------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
Q
T
-
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
-----
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
-----
N
E
R
Y
P
G
T
P
----
D
----
V
P
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
------
129
HHSearch
62.17
30%
-91
- C4 -
-
1XEO
1
DEF_ECOLI
A:
[1-156]
--
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
-
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
------------
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
S
E
-----
N
R
----------
D
----
E
-
R
L
V
L
I
N
P
E
L
L
E
K
S
G
E
--
T
--
G
I
E
E
G
C
L
S
I
P
-
E
-
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
Q
Q
R
I
R
Q
------
38
PsiBlast_CBE
61.45
31%
-47
- C4 -
-
1VEV
3
DEF_LEPIN
A:
[5-167]
------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
Q
T
-
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
-----
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
-----
N
E
R
Y
P
G
T
P
----
D
----
V
P
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
------
34
PsiBlast_CBE
61.22
31%
-46
- C4 -
-
1VEZ
8
DEF_LEPIN
A:
[5-167]
------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
Q
T
-
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
-----
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
-----
N
E
R
Y
P
G
T
P
----
D
----
V
P
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
------
37
PsiBlast_CBE
60.74
31%
-45
- C4 -
-
1VEV
2
DEF_LEPIN
B:
[5-167]
------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
Q
T
-
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
-----
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
-----
N
E
R
Y
P
G
T
P
----
D
----
V
P
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
------
32
PsiBlast_CBE
60.66
31%
-51
- C4 -
-
1Y6H
4
DEF_LEPIN
A:
[5-167]
------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
Q
T
-
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
-----
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
-----
N
E
R
Y
P
G
T
P
----
D
----
V
P
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
------
31
PsiBlast_CBE
60.40
31%
-40
- C4 -
-
1Y6H
5
DEF_LEPIN
B:
[5-167]
------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
Q
T
-
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
-----
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
-----
N
E
R
Y
P
G
T
P
----
D
----
V
P
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
------
33
PsiBlast_CBE
60.35
31%
-47
- C4 -
-
1VEZ
7
DEF_LEPIN
B:
[5-167]
------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
Q
T
-
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
-----
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
-----
N
E
R
Y
P
G
T
P
----
D
----
V
P
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
------
36
PsiBlast_CBE
60.30
31%
-48
- C4 -
-
1VEY
1
DEF_LEPIN
A:
[5-167]
------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
Q
T
-
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
-----
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
-----
N
E
R
Y
P
G
T
P
----
D
----
V
P
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
------