@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXH5: (2018-01-04 )
MNSLTSTYRLSNGYEIPVVGFGTWQTPDGDVAVSSVKEALAAGYRHIDTAQGYKNEESVGQAIKESGIPREEIFLTTKLWNANHSYELVMSSFEESLKKLQTDYLDLFLIHWPNPVAFRDNWEQANADTWRAFEELYEAGKIKAIGVSNFLPHHLDTLAKTAKIMPMVNQVFLAPGELQTTVVEYAKKHDMILEAYSPLGTGKIFDVPEMKQIAEAHDKTIAQVALRWSLQHEFLPLPKSVTPSRIKENTELFDFELTEEEMKQIDQLDGVVGKAKDPDTTQF
Atome Classification :
(41 SA)
.........10........20.......--.30........40........50........60...----..-----...70........80........90........100.......110.......120------.----.....--------.--------------.130.......140.......150.......160--.......170.......180.......190.......200----------.-----------..-------..---..210.......220.......230.......240.......250.......260.......270.......280.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNSLT
S
T
Y
RLSNG
Y
E
I
P
V
V
G
FGTWQTPD--G
D
V
A
V
S
S
V
K
E
A
L
A
A
G
YRHIDTAQGYK
N
E
E
S
V
G
Q
A
I
K
----
E
S-----GI
P
R
E
E
I
F
L
T
T
K
LWNAN
H
S
Y
E
L
V
M
S
S
F
E
E
S
L
K
K
L
Q
T
D
Y
L
D
L
F
L
I
HWPNPVAFRDN-------W----EQAN
A
--------
D
--------------
T
W
R
A
F
E
E
L
Y
EAG
K
I
K
A
I
GVSNFL
P
H
H
L
D
T
L
A
K
T
A
--
K
I
M
P
M
V
N
Q
V
FLAP
G
E
L
Q
T
T
V
V
E
Y
A
K
KH
D
M
I
L
E
AYSPLGTG----------K-----------IF-------D
V
---
P
E
M
K
Q
I
A
E
A
H
D
K
T
I
A
Q
V
A
L
R
WSLQHEFLPLPKSV
T
P
S
R
I
KENT
E
L
F
D
F
EL
T
E
E
E
M
K
Q
I
D
Q
L
D
G
VVGKAKDPDTTQF
6
PsiBlast_PDB
94.89
49%
-70
- C7 -
-
3D3F
1
GR_BACSU
A:
[3-275]
--
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
----
E
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
G
K
D
K
Y
K
D
-----------------------------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
Q
G
----------
Q
-----------
L
L
-------
D
N
---
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
K
D
E
R
V
G
P
N
P
D
E
L
L
F
8
PsiBlast_PDB
94.66
49%
-71
- C7 -
-
3F7J
-
GR_BACSU
A:
[4-276]
--
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
----
E
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
G
K
D
K
Y
K
D
-----------------------------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
Q
G
----------
Q
-----------
L
L
-------
D
N
---
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
K
D
E
R
V
G
P
N
P
D
E
L
L
F
25
PsiBlast_CBE
93.79
49%
-76
- C7 -
-
3D3F
1
GR_BACSU
B:
[3-275]
--
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
----
E
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
G
K
D
K
Y
K
D
-----------------------------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
Q
G
----------
Q
-----------
L
L
-------
D
N
---
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
K
D
E
R
V
G
P
N
P
D
E
L
L
F
24
PsiBlast_CBE
92.82
47%
-82
- C7 -
-
1VBJ
2
PGFS_TRYBB
B:
[7-277]
--
A
L
T
Q
S
L
K
L
S
N
G
V
M
M
P
V
L
G
F
G
M
W
K
L
Q
D
--
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
----
S
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
G
K
D
K
F
-------------------
I
--------
D
--------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
--
K
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
Q
G
----------
H
-----------
L
V
-------
E
D
---
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
--
A
G
H
R
Y
G
P
D
P
E
V
F
120
HHSearch
92.53
51%
-68
- C7 -
-
3F7J
-
GR_BACSU
A:
[10-276]
--------
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
--
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
----
E
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
G
K
D
-------------------
K
Y
K
--------
D
--------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
Q
G
----------
Q
-----------
L
L
-------
D
N
---
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
K
D
E
R
V
G
P
N
P
D
E
L
L
F
5
PsiBlast_PDB
92.32
47%
-87
- C7 -
-
1VBJ
2
PGFS_TRYBB
A:
[7-277]
--
A
L
T
Q
S
L
K
L
S
N
G
V
M
M
P
V
L
G
F
G
M
W
K
L
Q
D
--
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
----
S
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
G
K
D
K
F
-------------------
I
--------
D
--------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
--
K
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
Q
G
----------
H
-----------
L
V
-------
E
D
---
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
--
A
G
H
R
Y
G
P
D
P
E
V
F
129
HHSearch
92.10
50%
-85
- C7 -
-
3O0K
4
?
B:
[25-282]
---
T
V
P
T
V
K
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
---
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
----
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
P
S
K
-----------------
D
L
F
M
--------
E
--------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
------------------------
L
L
-------
E
D
---
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
---------------
114
HHSearch
91.51
49%
-90
- C7 -
-
1VBJ
2
PGFS_TRYBB
A:
[8-266]
---
L
T
Q
S
L
K
L
S
N
G
V
M
M
P
V
L
G
F
G
M
W
K
L
Q
D
--
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
----
S
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
G
K
D
-------------------
K
F
I
--------
D
--------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
--
K
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
Q
G
----------
H
-----------
L
V
-------
E
D
---
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
A
-------------
130
HHSearch
91.48
50%
-84
- C7 -
-
3O0K
4
?
A:
[23-282]
-
I
M
T
V
P
T
V
K
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
---
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
----
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
P
S
K
-----------------
D
L
F
M
--------
E
--------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
Q
G
----------------------
L
L
-------
E
D
---
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
---------------
116
HHSearch
91.47
47%
-70
- C7 -
-
4G5D
1
PGFS_LEIMA
A:
[9-288]
---
D
K
A
M
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
----
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
R
G
K
D
I
L
S
K
-------
E
----
G
K
K
Y
L
--------
D
--------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
Q
G
----------
K
-----------
L
L
-------
S
N
---
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
N
S
R
Y
G
P
D
P
D
E
A
Q
F
23
PsiBlast_CBE
91.38
46%
-90
- C7 -
-
4FZI
1
PGFS_TRYCC
B:
[13-283]
----
Y
N
C
V
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
----
E
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
G
K
K
K
F
-------------------
V
--------
D
--------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
S
-----------------------
I
L
-------
K
N
---
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
E
D
K
R
I
G
A
D
P
D
N
---
4
PsiBlast_PDB
91.14
46%
-57
- C7 -
-
4GIE
1
PGFS_TRYCC
A:
[9-283]
M
N
C
N
Y
N
C
V
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
----
E
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
G
K
K
K
F
-------------------
V
--------
D
--------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
S
G
----------
E
EAG--------
I
L
-------
K
N
---
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
E
D
K
R
I
G
A
D
P
D
N
---
28
PsiBlast_CBE
90.58
49%
-83
- C7 -
-
3O0K
4
?
B:
[28-283]
------
T
V
K
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
---
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
----
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
P
S
-----------------
K
D
L
F
M
--------
E
--------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
------------------------
L
L
-------
E
D
---
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
--------------
27
PsiBlast_CBE
90.55
49%
-84
- C7 -
-
3O0K
3
?
C:
[28-283]
------
T
V
K
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
---
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
----
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
P
S
-----------------
K
D
L
F
M
--------
E
--------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
------------------------
L
L
-------
E
D
---
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
--------------
7
PsiBlast_PDB
90.32
49%
-81
- C7 -
-
3O0K
4
?
A:
[28-283]
------
T
V
K
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
---
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
----
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
P
S
-----------------
K
D
L
F
M
--------
E
--------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
Q
G
----------------------
L
L
-------
E
D
---
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
--------------
115
HHSearch
90.26
47%
-76
- C7 -
-
4F40
10
PGFS_LEIMA
B:
[9-288]
---
D
K
A
M
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
----
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
R
G
K
D
I
L
S
K
-------
E
----
G
K
K
Y
L
--------
D
--------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
------------
K
-----------
L
L
-------
S
N
---
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
N
S
R
Y
G
P
D
P
D
E
A
Q
F
119
HHSearch
90.15
50%
-70
- C7 -
-
4Q3M
-
?
A:
[2-261]
-----
H
S
V
K
L
N
N
N
Y
E
M
P
I
I
G
L
G
T
F
R
S
K
K
---
N
D
A
Y
N
A
V
K
A
A
L
E
G
G
Y
R
H
I
D
T
A
M
I
Y
G
N
E
E
E
V
G
R
A
I
K
----
D
S
-----
N
I
P
R
E
E
I
F
V
T
T
K
L
W
N
T
D
Q
G
Y
E
K
T
L
E
A
F
N
T
S
L
K
N
L
G
L
D
Y
I
D
L
Y
L
I
H
W
F
K
G
Y
------------------
D
N
A
L
--------
S
--------------
T
Y
R
A
F
E
T
L
Y
E
E
G
K
V
K
A
I
G
V
S
N
F
N
V
H
H
L
M
Y
L
M
E
N
A
--
K
I
P
P
M
V
N
Q
V
E
T
H
V
T
L
Q
N
H
F
L
H
D
Y
C
K
K
N
N
I
Q
L
E
A
Y
A
P
L
M
S
H
----------
Q
-----------
I
K
D
L
L
----
S
N
---
E
T
M
A
K
I
A
K
K
H
D
K
T
I
P
Q
I
A
I
R
W
L
I
E
R
E
I
V
V
I
P
K
S
I
T
P
E
R
I
V
Q
N
F
D
V
F
D
F
T
L
D
E
E
D
M
K
S
I
R
S
V
N
T
-------------
9
PsiBlast_PDB
89.72
50%
-75
- C7 -
-
4Q3M
-
?
A:
[5-260]
--------
K
L
N
N
N
Y
E
M
P
I
I
G
L
G
T
F
R
S
K
K
--
N
D
-
A
Y
N
A
V
K
A
A
L
E
G
G
Y
R
H
I
D
T
A
M
I
Y
G
N
E
E
E
V
G
R
A
I
K
----
D
S
-----
N
I
P
R
E
E
I
F
V
T
T
K
L
W
N
T
D
Q
G
Y
E
K
T
L
E
A
F
N
T
S
L
K
N
L
G
L
D
Y
I
D
L
Y
L
I
H
W
-----
F
K
-
G
-------
Y
----
D
N
A
-
L
--------
S
--------------
T
Y
R
A
F
E
T
L
Y
E
E
G
K
V
K
A
I
G
V
S
N
F
N
V
H
H
L
M
Y
L
M
E
N
A
--
K
I
P
P
M
V
N
Q
V
E
T
H
V
T
L
Q
N
H
F
L
H
D
Y
C
K
K
N
N
I
Q
L
E
A
Y
A
P
L
M
S
H
----------
Q
-----------
I
K
-------
D
L
L
S
N
E
T
M
A
K
I
A
K
K
H
D
K
T
I
P
Q
I
A
I
R
W
L
I
E
R
E
I
V
V
I
P
K
S
I
T
P
E
R
I
V
Q
N
F
D
V
F
D
F
T
L
D
E
E
D
M
K
S
I
R
S
V
N
--------------
121
HHSearch
89.47
48%
-61
- C7 -
-
4GIE
1
PGFS_TRYCC
A:
[9-273]
M
N
C
N
Y
N
C
V
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
----
E
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
G
K
K
-------------------
K
F
V
--------
D
--------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
S
G
----------
E
-----------
E
A
GIL----
K
N
---
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
E
-------------
26
PsiBlast_CBE
89.14
49%
-80
- C7 -
-
3O0K
3
?
D:
[28-283]
------
T
V
K
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
---
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
----
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
P
S
-----------------
K
D
L
F
M
--------
E
--------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
------------
K
-----------
L
L
-------
E
D
---
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
--------------
2
PsiBlast_PDB
88.83
47%
-69
- C7 -
-
4G5D
1
PGFS_LEIMA
A:
[15-288]
---------
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
----
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
R
G
K
D
I
L
S
K
-------
E
----
G
K
K
Y
L
--------
D
--------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
Q
G
----------
K
-----------
L
L
-------
S
N
---
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
N
S
R
Y
G
P
D
P
D
E
A
Q
F
21
PsiBlast_CBE
88.39
47%
-68
- C7 -
-
4G5D
1
PGFS_LEIMA
B:
[15-288]
---------
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
----
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
R
G
K
D
I
L
S
K
-------
E
----
G
K
K
Y
L
--------
D
--------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
Q
G
----------
K
-----------
L
L
-------
S
N
---
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
N
S
R
Y
G
P
D
P
D
E
A
Q
F
3
PsiBlast_PDB
87.73
46%
-56
- C7 -
-
4FZI
1
PGFS_TRYCC
A:
[13-283]
----
Y
N
C
V
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
--
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
----
E
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
G
K
K
K
F
-------------------
V
--------
D
--------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
S
G
----------
E
EAG--------
I
L
-------
K
N
---
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
E
D
K
R
I
G
A
D
P
D
N
---
22
PsiBlast_CBE
87.60
47%
-75
- C7 -
-
4F40
10
PGFS_LEIMA
B:
[15-288]
---------
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
----
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
R
G
K
D
I
L
S
K
-------
E
----
G
K
K
Y
L
--------
D
--------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
------------
K
-----------
L
L
-------
S
N
---
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
N
S
R
Y
G
P
D
P
D
E
A
Q
F
1
PsiBlast_PDB
87.07
47%
-71
- C7 -
-
4F40
10
PGFS_LEIMA
A:
[15-288]
---------
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
--
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
----
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
R
G
K
D
I
L
S
K
-------
E
----
G
K
K
Y
L
--------
D
--------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
------------
K
-----------
L
L
-------
S
N
---
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
N
S
R
Y
G
P
D
P
D
E
A
Q
F
48
PsiBlast_CBE
84.41
43%
-48
- C7 -
-
1A80
1
DKGA_CORSC
A:
[7-268]
---------
L
N
D
G
N
S
I
P
Q
L
G
Y
G
V
F
K
V
P
P
--
A
D
T
Q
-
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
I
A
----
A
S
-----
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
T
P
A
A
--
D
N
-------
Y
----
V
H
A
--------------------------
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
T
--
G
V
V
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
Q
G
----------
K
YD---------
L
F
-------
G
A
---
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
G
F
V
V
F
P
K
S
V
R
R
E
R
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
P
G
D
G
S
G
R
-------
14
PsiBlast_PDB
82.67
41%
-34
- C7 -
-
1MZR
2
DKGA_ECOLI
A:
[26-294]
-----
T
V
I
K
L
Q
D
G
N
V
M
P
Q
L
G
L
G
V
W
Q
A
S
N
--
E
E
V
-
I
T
A
I
Q
K
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
N
E
E
G
V
G
K
A
L
K
----
N
A
-----
S
V
N
R
E
E
L
F
I
T
T
K
L
W
N
D
D
H
K
R
P
--
R
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
P
V
P
A
I
--
D
H
-------
Y
----
V
E
A
--------------------------
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
D
E
T
--
G
V
T
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
A
Q
G
GK--------
G
-----------
V
F
-------
D
Q
---
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
G
L
V
V
I
P
K
S
V
T
P
S
R
I
A
E
N
F
D
V
W
D
F
R
L
D
K
D
E
L
G
E
I
A
K
L
D
Q
--
G
K
R
L
G
P
D
P
D
Q
F
17
PsiBlast_PDB
80.62
37%
-8
- C7 -
-
3CV7
2
AK1A1_PIG
A:
[3-296]
----
A
S
C
V
L
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
--
G
Q
V
K
-
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
----
E
T
VGPGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
E
R
G
D
N
-------
P
----
F
P
K
N
A
--------
D
G
T
I
R
Y
D
ATH
Y
K
D
--
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
S
S
----------
D
RAWRDPNEPV-
L
L
-------
E
E
---
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
--------------
15
PsiBlast_PDB
79.35
38%
-9
- C7 -
-
4GAC
1
AK1A1_MOUSE
A:
[2-292]
----
A
S
S
V
L
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
--
G
Q
V
K
-
A
A
I
K
H
A
L
S
A
G
Y
R
H
I
D
C
A
S
V
Y
G
N
E
T
E
I
G
E
A
L
K
----
E
S
VGSGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
E
R
G
D
N
-------
P
----
F
P
K
N
A
--------
D
G
T
V
R
Y
D
STH
Y
K
E
--
T
W
K
A
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
N
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
L
G
S
S
----------
D
RAWRHPDEPV-
L
L
-------
E
E
---
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
I
N
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
--------------
52
PsiBlast_CBE
77.02
39%
11
- C7 -
-
4JIH
2
AK1BA_HUMAN
A:
[9-291]
---------
L
S
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
V
K
-
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
K
S
G
D
D
-------
L
F
P
K
D
D
K
G
N
A
I
G
G
KAT
F
L
D
--------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
S
P
DRPWAKPEDP
S
-----------
L
L
-------
E
D
---
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
------------------
55
PsiBlast_CBE
76.58
39%
15
- C7 -
-
4GQG
1
AK1BA_HUMAN
A:
[9-291]
---------
L
S
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
V
K
-
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
K
S
G
D
D
-------
L
F
P
K
D
D
K
G
N
A
I
G
G
KAT
F
L
D
--------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
S
P
DRPWAKPEDP
S
-----------
L
L
-------
E
D
---
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
------------------
51
PsiBlast_CBE
76.55
38%
10
- C7 -
-
4I5X
2
AK1BA_HUMAN
A:
[3-291]
---
M
A
T
F
V
E
L
S
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
V
K
-
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
K
S
G
D
D
-------
L
FPKD
D
K
G
N
A
I
G
G
KAT
F
L
D
--------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
S
P
DRPWAKPEDP
S
-----------
L
L
-------
E
D
---
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
------------------
50
PsiBlast_CBE
76.39
39%
15
- C7 -
-
4GA8
2
AK1BA_HUMAN
A:
[7-289]
---------
L
S
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
V
K
-
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
K
S
G
D
D
-------
L
F
P
K
D
D
K
G
N
A
I
G
G
KAT
F
L
D
--------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
S
P
DRPWAKPEDP
S
-----------
L
L
-------
E
D
---
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
------------------
53
PsiBlast_CBE
76.35
39%
12
- C7 -
-
1ZUA
2
AK1BA_HUMAN
X:
[8-290]
---------
L
S
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
V
K
-
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
K
IQEK-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
K
S
G
D
D
-------
L
FPKD
D
K
G
N
A
IGGKATFL
D
--------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
S
P
DRPWAKPEDP
S
-----------
L
L
-------
E
D
---
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
------------------
56
PsiBlast_CBE
76.22
39%
11
- C7 -
-
4GQ0
2
AK1BA_HUMAN (first)
A:
[9-291]
---------
L
S
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
V
K
-
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
K
S
G
D
D
-------
L
F
P
K
D
D
K
G
N
A
I
G
G
K
A
T
F
L
D
--------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
S
P
DRPWAKPEDP
S
-----------
L
L
-------
E
D
---
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
------------------
54
PsiBlast_CBE
75.52
39%
11
- C7 -
-
4JII
2
AK1BA_HUMAN
X:
[9-291]
---------
L
S
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
V
K
-
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
K
IQEK-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
K
S
G
D
D
-------
L
FPKD
D
K
G
N
A
IGGKATFL
D
--------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
S
P
DRPWAKPEDP
S
-----------
L
L
-------
E
D
---
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
------------------
49
PsiBlast_CBE
75.35
39%
17
- C7 -
-
4GAB
1
AK1BA_HUMAN
A:
[7-289]
---------
L
S
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
--
G
K
V
K
-
E
A
V
K
V
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
----
E
K
I
Q
E
K-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
K
S
G
D
D
-------
L
F
P
K
D
D
K
G
N
A
I
G
G
KAT
F
L
D
--------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
G
S
P
DRPWAKPEDP
S
-----------
L
L
-------
E
D
---
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
------------------
43
PsiBlast_CBE
73.65
37%
-
- C7 -
-
1CWN
1
AK1A1_PIG
A:
[2-292]
----
A
S
C
V
L
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
--
G
Q
V
K
-
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
T
----
E
T
VGPGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
E
R
G
D
N
-------
P
----
F
P
K
N
A
--------
D
GT
I
R
Y
D
ATH
Y
K
D
--
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
S
S
----------
D
RAWRDPNEPV-
L
L
-------
E
E
---
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
P
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
--------------
20
PsiBlast_PDB
73.64
37%
-
- C7 -
-
1AE4
1
AK1A1_PIG
A:
[3-293]
----
A
S
C
V
L
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
--
G
Q
V
K
-
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
T
----
E
T
VGPGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
E
R
G
D
N
-------
P
----
F
P
K
N
A
--------
D
GTIRYDATH
Y
K
D
--
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
S
S
----------
D
RAWRDPNEPV-
L
L
-------
E
E
---
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
P
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
--------------
132
HHSearch
71.58
39%
15
- C7 -
-
3H7U
1
AKRC9_ARATH
A:
[24-307]
---
A
I
T
F
F
K
L
N
T
G
A
K
F
P
S
V
G
L
G
T
W
Q
A
S
P
---
G
L
V
G
D
A
V
A
A
A
V
K
I
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
L
K
----
K
L
F
E
D
R-
V
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
A
R
I
K
K
G
S
V
GIKPENL
L
----
P
V
D
I
P
--------
S
--------------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
E
L
A
--
R
V
P
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
L
G
S
P
----------
G
-----------
T
T
WLKSDVL
K
N
---
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
G
H
S
V
L
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
P
D
Y
M
F
A
K
F
A
E
I
E
Q
-------------
103
PsiBlast_CBE
68.90
37%
31
- C7 -
-
4WRH
5
AK1C3_HUMAN
A:
[6-300]
-----
Q
C
V
K
L
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
P
E
VP
R
S
K
A
L
E
V
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
T
F
H
R
P
E
L
V
R
P
A
L
E
N
S
L
K
K
A
Q
L
D
Y
V
D
L
Y
L
I
H
--
S
P
M
S
L
K
P
G
-------
E
----
E
L
S
P
T
--------
D
ENGKV
I
F
D
I
V
D
L
C
T
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
GL
K
Y
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
R
S
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
S
Q
----------
R
DKRWVDPNSPV
L
L
-------
E
D
---
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
A
E
D
M
K
A
I
D
G
L
D
--------------