@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXK8: (2018-01-04 )
MKITLLYGGRSAEHEVSILSAFSVLNAIYYNYYQVQLVFITKEGQWVKGPLLTEKPASKDVLHLSWDPSGQTEEGFTGKVINPGEIKEEGAIVFPVLHGPNGEDGTIQGFLETLNMPYVGAGVLTSACAMDKIMTKYILQAAGVPQVPYVPVLKNQWKENPKKVFDQCEGSLLYPMFVKPANMGSSVGITKAENREELQNALATAYQYDSRAIVEQGIEAREIEVAVLGNEDVRTTLPGEVVKDVAFYDYEAKYINNKIEMQIPAEVPEEVYQKAQEYAKLAYTMLGGSGLSRCDFFLTNKNELFLNELNSMPGFTEFSMYPLLWENMGLKYGDLIEELIQLGMNRYHQRQSFFEKNE
Atome Classification :
(48 SA)
--.........10........20.......-.-30.........40.....-...50--.......-.----.60-...--..-----..-----..70...--.....----80..--......90.--..--------------......100.......110.......120.......130.......140-.-......150-.........-160.......170.......180.......190.......200.......210.......-220........230--....------....-240-----..-----.....250...-..-.-.260-------.........270.......280.......290.......300.......310.......320.......330.......340.......350......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--
M
K
I
T
L
L
YGGRSAE
H
E
V
S
I
L
S
A
F
S
V
L
N
A
I
-
Y
-
Y
-
N
Y
Y
Q
V
Q
L
V
F
I
TKEGQW-VKGP---LLTEKPA-S----K
D
--
V
L
H
--
L
S-----WD-----PSGQTEE--GFTGK----VI
N
P
--
G
EIKEEG-
A
--
I
V
--------------
F
P
V
L
HGPNGED
G
T
I
Q
G
F
L
E
TLNMPYV
G
A
G
V
L
T
S
A
C
A
M
D
K
I
M
T
K
Y
I
L
Q
AA-G-VPQVPYV---
P
V
L
K
N
Q
WKE-
N
P
K
K
V
F
D
QCEG
S
L
L
Y
P
M
F
VKPANMGSSVGITKAE
N
R
E
E
L
Q
N
A
L
A
T
A
Y
QY
D
S
R
A
I
V
E
QGIE-
A
-
R
E
I
E
V
A
V
LGNE---DVRT------TL
P
G
-
E
V
V
-----
K
D
-----
V
AFYDY
E
A
K
YI-N
N
-
K
-
I
E
---------
M
QIPAEV
P
E
E
V
Y
Q
K
A
Q
E
Y
A
K
L
A
Y
T
MLGGSGL
S
R
C
D
F
F
LTNK
N
E
L
F
L
N
E
L
NSMPGFTEFS
M
Y
P
L
L
W
E
NMGLK
Y
G
D
L
I
E
E
L
I
Q
L
G
M
N
R
Y
H
Q
R
Q
S
F
FEKNE
2
PsiBlast_PDB
91.77
47%
-104
- C1 -
-
2I87
-
DDL_STAAC
A:
[6-349]
----
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
-
D
-
K
-
D
K
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
-
R
K
Q
N
---
N
I
T
A
E
I
K
-
S
----
T
D
--
E
L
H
--
L
E
-------------
N
G
E
A
L
E
----
I
S
Q
----
L
L
K
E
--
S
S
S
G
Q
P
Y
-
D
--
A
V
--------------
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
---
S
F
L
R
S
E
Y
E
K
-
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
---
Y
P
E
A
------
T
W
P
G
-
E
V
V
-----
K
D
-----
V
A
F
--------------
V
Q
---------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
-------
103
HHSearch
90.33
47%
-103
- C1 -
-
2I80
1
DDL_STAAC
B:
[4-350]
--
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
-
D
-
K
-
D
K
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
-
R
K
Q
N
---
N
I
T
A
E
---
I
----
K
S
--
T
D
----
E
-----
L
H
-----
L
E
-
N
G
E
A
--
L
E
I
S
Q
----
L
L
K
E
--
S
S
S
G
Q
P
Y
-
D
--
A
V
--------------
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
---
S
F
L
R
S
E
Y
E
K
-
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
---
Y
P
E
A
------
T
W
P
G
-
E
V
V
-----
K
D
-----
V
A
F
--------------
V
Q
---------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
------
21
PsiBlast_CBE
89.98
47%
-106
- C1 -
-
2I8C
1
DDL_STAAC
B:
[6-349]
----
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
-
D
-
K
-
D
K
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
-
R
K
Q
N
---
N
I
T
A
E
I
K
-
S
----
T
D
--
E
L
H
--
L
E
-------------
N
G
E
A
L
E
----
I
S
Q
----
L
L
K
E
--
S
S
S
G
Q
P
Y
-
D
--
A
V
--------------
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
---
S
F
L
R
S
E
Y
E
K
-
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
---
Y
P
E
A
------
T
W
P
G
-
E
V
V
-----
K
D
-----
V
A
F
--------------
V
Q
---------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
-------
22
PsiBlast_CBE
89.47
47%
-108
- C1 -
-
2I80
1
DDL_STAAC
B:
[6-349]
----
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
-
D
-
K
-
D
K
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
-
R
K
Q
N
---
N
I
T
A
E
I
K
-
S
----
T
D
--
E
L
H
--
L
E
-------------
N
G
E
A
L
E
----
I
S
Q
----
L
L
K
E
--
S
S
S
G
Q
P
Y
-
D
--
A
V
--------------
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
---
S
F
L
R
S
E
Y
E
K
-
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
---
Y
P
E
A
------
T
W
P
G
-
E
V
V
-----
K
D
-----
V
A
F
--------------
V
Q
---------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
-------
3
PsiBlast_PDB
89.18
47%
-102
- C1 -
-
2I8C
1
DDL_STAAC
A:
[6-349]
----
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
-
D
-
K
-
D
K
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
-
R
K
Q
N
---
N
I
T
A
E
I
K
-
S
----
T
D
--
E
L
H
--
L
E
-------------
N
G
E
A
L
E
----
I
S
Q
----
L
L
K
E
--
S
S
S
G
Q
P
Y
-
D
--
A
V
--------------
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
---
S
F
L
R
S
E
Y
E
K
-
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
---
Y
P
E
A
------
T
W
P
G
-
E
V
V
-----
K
D
-----
V
A
F
--------------
V
Q
---------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
-------
95
HHSearch
89.09
46%
-104
- C1 -
-
2I87
-
DDL_STAAC
B:
[4-355]
--
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
-
D
-
K
-
D
K
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
-
R
K
Q
N
---
N
I
T
A
E
---
I
----
K
S
--
T
D
E
---
L
-----
H
L
-----
E
N
--
G
E
---
L
E
I
S
Q
----
L
L
K
E
--
S
S
S
G
Q
P
Y
-
D
--
A
V
--------------
F
P
L
L
H
G
P
--
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
---
S
F
L
R
S
E
Y
E
K
-
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
---
Y
P
E
A
------
T
W
P
G
-
E
V
V
-----
K
D
-----
V
A
F
--------------
V
Q
---------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
K
I
-
4
PsiBlast_PDB
88.27
47%
-104
- C1 -
-
2I80
1
DDL_STAAC
A:
[6-349]
----
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
-
D
-
K
-
D
K
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
-
R
K
Q
N
---
N
I
T
A
E
I
K
-
S
----
T
D
--
E
L
H
--
L
E
-------------
N
G
E
A
L
E
----
I
S
Q
----
L
L
K
E
--
S
S
S
G
Q
P
Y
-
D
--
A
V
--------------
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
---
S
F
L
R
S
E
Y
E
K
-
Y
E
H
N
I
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
---
Y
P
E
A
------
T
W
P
G
-
E
V
V
-----
K
D
-----
V
A
F
--------------
V
Q
---------
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
-------
102
HHSearch
84.47
56%
-28
- C1 -
-
3K3P
-
DDL_STRMU
B:
[4-346]
--
E
T
L
V
L
L
Y
G
G
R
S
A
E
R
D
V
S
V
L
S
A
E
S
V
M
R
A
I
-
N
-
Y
-
D
N
F
L
V
K
T
Y
F
I
T
Q
A
G
D
F
-
I
K
T
Q
---
E
F
D
S
Q
P
S
-------
D
K
L
M
T
N
--
D
T
-----
I
I
-----
A
S
-----------
Q
----
K
I
K
P
--
S
D
I
Y
E
E
E
-
A
--
V
V
--------------
F
P
V
L
H
G
P
M
G
E
D
G
S
I
Q
G
F
L
E
V
L
K
M
P
Y
V
G
T
N
I
L
S
S
S
V
A
M
D
K
I
T
T
N
Q
V
L
E
S
A
T
T
-
I
P
Q
V
A
Y
V
---
A
L
I
E
G
E
P
----
L
E
S
K
L
A
E
V
E
E
K
L
I
Y
P
V
F
V
K
P
A
N
-----
G
I
S
K
A
E
N
R
T
D
L
K
Q
A
I
A
L
A
L
K
Y
D
S
R
V
L
I
E
Q
G
V
D
-
A
-
R
E
I
E
V
G
I
L
G
N
T
---
D
V
K
T
------
T
L
P
G
-
E
I
V
------------------------------
T
---------
M
A
I
P
A
E
I
D
P
V
I
V
E
K
M
R
D
Y
A
A
T
A
F
R
T
L
G
C
C
G
L
S
R
C
D
F
F
L
T
E
D
G
K
V
Y
L
N
E
L
N
T
M
P
G
F
T
--
S
M
Y
P
L
L
W
E
N
M
G
L
S
Y
S
V
L
I
E
E
L
V
S
L
A
K
E
M
F
D
K
R
E
S
------
1
PsiBlast_PDB
81.54
54%
-47
- C1 -
-
3K3P
-
DDL_STRMU
A:
[6-346]
----
L
V
L
L
Y
G
G
R
S
A
E
R
D
V
S
V
L
S
A
E
S
V
M
R
A
I
-
N
-
Y
-
D
N
F
L
V
K
T
Y
F
I
T
Q
A
G
D
F
-
I
K
T
Q
---
E
F
D
S
Q
P
S
-------
D
--
K
L
M
--
T
N
-----------------
D
T
--
I
I
A
S
Q
----
K
I
K
P
--
S
D
I
Y
E
E
E
-
A
--
V
V
--------------
F
P
V
L
H
G
P
M
G
E
D
G
S
I
Q
G
F
L
E
V
L
K
M
P
Y
V
G
T
N
I
L
S
S
S
V
A
M
D
K
I
T
T
N
Q
V
L
E
S
A
-
T
T
I
P
Q
V
A
Y
V
---
A
L
I
E
G
E
P
L
E
-
S
K
---
L
A
E
V
E
E
K
L
I
Y
P
V
F
V
K
P
A
N
------
I
S
K
A
E
N
R
T
D
L
K
Q
A
I
A
L
A
L
K
Y
D
S
R
V
L
I
E
Q
G
V
D
-
A
-
R
E
I
E
V
G
I
L
G
N
T
---
D
V
K
T
------
T
L
P
G
-
E
I
V
------------------------------
T
---------
M
A
I
P
A
E
I
D
P
V
I
V
E
K
M
R
D
Y
A
A
T
A
F
R
T
L
G
C
C
G
L
S
R
C
D
F
F
L
T
E
D
G
K
V
Y
L
N
E
L
N
T
M
P
G
F
T
--
S
M
Y
P
L
L
W
E
N
M
G
L
S
Y
S
V
L
I
E
E
L
V
S
L
A
K
E
M
F
D
K
R
E
S
------
33
PsiBlast_CBE
75.03
42%
-49
- C1 -
-
2YZN
1
DDL_THET8
C:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
-----------
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
29
PsiBlast_CBE
73.71
42%
-48
- C1 -
-
2ZDH
2
DDL_THET8
B:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
F
Y
--------
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
26
PsiBlast_CBE
73.62
42%
-41
- C1 -
-
2ZDQ
3
DDL_THET8
B:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
-
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
16
PsiBlast_PDB
73.01
42%
-41
- C1 -
-
2ZDQ
3
DDL_THET8
A:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
-
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
100
HHSearch
72.97
45%
-49
- C1 -
-
2ZDG
1
DDL_THET8
C:
[1-318]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
---
F
P
T
D
L
A
V
I
A
Q
D
G
R
--
W
-
L
L
G
E
---
K
A
L
T
A
---
L
----
E
A
--
K
A
A
--
P
-----------------
E
------
G
E
H
----
P
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
-----------
P
V
V
P
F
D
P
P
F
F
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
F--
G
E
-
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
-
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
--------------
5
PsiBlast_PDB
72.81
40%
5
- C1 -
-
3I12
1
DDLA_SALTY
A:
[4-354]
--
L
R
V
G
I
V
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
K
N
I
V
D
A
I
-
D
-
K
-
T
R
F
D
V
V
L
L
G
I
D
K
A
G
Q
W
-
H
V
N
D
---
A
E
N
Y
L
Q
N
-
A
----
D
D
--
P
A
H
--
I
A
-----
L
R
-----
P
S
A
I
S
L
A
--
Q
V
P
G
K
HQHQ
L
I
N
A
QN
G
Q
P
L
P
T
V
-
D
--
V
I
--------------
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
M
L
R
V
A
N
L
P
F
V
G
S
D
V
L
S
S
A
A
C
M
D
K
D
V
A
K
R
L
L
R
D
A
-
G
-
L
N
I
A
P
F
I
---
T
L
T
R
T
N
R
H
A
-
F
S
---
F
A
E
V
E
S
R
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
K
V
A
N
E
A
Q
Y
Q
Q
A
V
A
L
A
F
E
F
D
H
K
V
V
V
E
Q
G
I
K
-
G
-
R
E
I
E
C
A
V
L
G
N
D
---
N
P
Q
A
------
S
T
C
G
-
E
I
V
-----
L
N
-----
S
E
F
Y
--
D
T
K
Y
I
D
D
N
-
G
-
A
Q
---------
V
V
V
P
A
Q
I
P
S
E
V
N
D
K
I
R
A
I
A
I
Q
A
Y
Q
T
L
G
C
A
G
M
A
R
V
D
V
F
L
T
A
D
N
E
V
V
I
N
E
I
N
T
L
P
G
F
T
N
I
S
M
Y
P
K
L
W
Q
A
S
G
L
G
Y
T
D
L
I
S
R
L
I
E
L
A
L
E
R
H
-----------
99
HHSearch
72.72
45%
-57
- C1 -
-
2ZDH
2
DDL_THET8
C:
[1-318]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
---
F
P
T
D
L
A
V
I
A
Q
D
G
R
--
W
-
L
L
G
E
---
K
A
L
T
A
---
L
----
E
A
--
K
A
A
--
P
-----------------
E
------
G
E
H
----
P
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
-----------
P
V
V
P
F
D
P
P
F
F
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
F--
G
E
-
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
F
Y
---
T
K
Y
T
-
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
--------------
14
PsiBlast_PDB
72.71
42%
-48
- C1 -
-
2ZDG
1
DDL_THET8
A:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
------------------------------
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
107
HHSearch
72.33
34%
-112
- C1 -
-
5D8D
-
DDL_ACIBC
D:
[8-305]
--
G
K
V
A
V
L
L
G
G
K
S
A
E
R
A
V
S
L
D
S
G
Q
A
V
L
D
A
L
-
L
-
R
-
S
G
V
Q
A
E
A
F
D
P
Q
D
R
S
---------------------------------------
V
-------------------------------
T
E
L
V
N
Y
-
D
--
R
A
--------------
F
I
V
L
H
G
R
G
G
E
D
G
Q
I
Q
G
V
L
E
W
L
N
I
P
Y
T
G
T
G
V
Q
G
S
A
I
G
M
D
K
V
K
T
K
Q
I
W
Q
G
S
-
D
-
L
P
T
A
P
Y
R
---
I
I
T
K
E
T
D
----
L
----
D
S
V
I
A
E
L
G
L
P
V
I
I
K
P
V
H
E
G
S
S
V
G
M
S
K
V
E
K
A
E
D
F
A
A
A
I
E
K
A
T
Q
H
D
A
V
V
M
A
E
K
W
I
T
-
G
-
R
E
F
T
I
S
F
L
N
G
Q
----
P
L
P
------
V
--
I
-
R
L
Q
----------------------------------------
Y
G
I
P
C
G
L
S
E
T
E
E
K
K
L
Q
A
L
C
L
R
A
F
Q
A
V
G
A
E
G
W
G
R
I
D
A
M
Q
D
E
Q
G
N
F
W
L
L
E
V
N
T
V
P
G
M
T
S
H
S
L
V
P
K
A
A
K
A
V
G
Y
S
F
D
E
L
C
V
A
I
L
E
Q
T
L
E
-------------
13
PsiBlast_PDB
72.33
42%
-51
- C1 -
-
2YZN
1
DDL_THET8
A:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
--
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
-
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
10
PsiBlast_PDB
72.32
39%
-11
- C1 -
-
3R5F
1
?
A:
[21-375]
--
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
-
D
-
P
-
Q
R
F
E
P
V
L
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
DSF
L
L
H
A
D
D
P
-
A
----
R
I
--
A
L
H
--
R
S
-----
G
R
G
V
A
L
L
P
G
A
Q
Q
Q
Q
--
L
---
R
----
P
I
Q
-----
A
L
A
Q
I
-
D
--
V
V
--------------
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
A
-
R
-
L
A
V
A
P
F
V
---
C
F
D
R
H
T
A
A
H
-
A
D
---
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
---
V
P
H
A
------
S
V
C
G
-
E
V
V
-----
V
------------------------
E
---------
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
-------
12
PsiBlast_PDB
72.28
42%
-45
- C1 -
-
2YZM
1
DDL_THET8
A:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
-
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
28
PsiBlast_CBE
72.00
42%
-46
- C1 -
-
2ZDH
2
DDL_THET8
C:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
F
Y
---
T
K
Y
T
-
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
15
PsiBlast_PDB
71.86
42%
-41
- C1 -
-
2ZDH
2
DDL_THET8
A:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
-
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
31
PsiBlast_CBE
71.63
42%
-39
- C1 -
-
2ZDG
1
DDL_THET8
C:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
-
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
35
PsiBlast_CBE
71.57
42%
-44
- C1 -
-
2YZM
1
DDL_THET8
C:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
-------------
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
36
PsiBlast_CBE
71.48
42%
-49
- C1 -
-
2YZM
1
DDL_THET8
B:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
F
-------
T
-
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
27
PsiBlast_CBE
70.55
42%
-43
- C1 -
-
2ZDH
2
DDL_THET8
D:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
-
P
G
-
R
-
A
E
---------
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
32
PsiBlast_CBE
70.43
42%
-49
- C1 -
-
2ZDG
1
DDL_THET8
B:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
-----------------
E
---------
L
L
I
P
A
P
L
D
--
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
30
PsiBlast_CBE
70.16
42%
-44
- C1 -
-
2ZDG
1
DDL_THET8
D:
[1-319]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
R
H
I
-
P
-
F
----
P
T
D
L
A
V
I
A
Q
D
G
R
W
--------
L
L
G
E
K
---
A
----
L
T
--
A
L
E
--
A
K
-----
A
A
-----
P
E
G
E
H
P
-------------
F
P
P
--
P
L
S
W
E
R
Y
-
D
--
V
V
--------------
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
---
A
V
R
K
G
E
P
P
V
-
V
P
F
D
P
P
F
F
V
----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
---
F
G
E
A
------
S
P
V
G
-
E
V
R
-----
Y
E
-----
A
P
---------------
A
E
---------
L
L
I
P
A
P
L
---
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
-------------
9
PsiBlast_PDB
70.06
39%
-5
- C1 -
-
3RFC
1
?
A:
[21-375]
--
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
-
D
-
P
-
Q
R
F
E
P
V
L
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
DSF
L
L
H
A
D
D
P
-
A
----
R
I
--
A
L
H
--
R
S
-----
G
R
G
V
A
L
L
P
G
A
Q
Q
Q
Q
--
L
---
R
----
P
I
Q
----
Q
A
L
A
Q
I
-
D
--
V
V
--------------
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
A
-
R
-
L
A
V
A
P
F
V
---
C
F
D
R
H
T
A
A
H
-
A
D
---
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
---
V
P
H
A
------
S
V
C
G
-
E
V
V
-----
V
------------------------
E
---------
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
-------
68
PsiBlast_CBE
69.02
32%
-27
- C1 -
-
1E4E
8
VANA_ENTFC
A:
[4-341]
--
I
K
V
A
I
L
F
G
G
C
S
E
E
H
D
V
S
V
K
S
A
I
E
I
A
A
N
I
-
N
-
K
-
E
K
Y
E
P
L
Y
I
G
I
T
K
S
G
V
W
--------
K
M
C
E
K
P
C
-
A
----
E
---------------
W
E
----------
N
E
--
N
C
Y
S
A
----
V
L
S
P
--
D
K
-
K
M
H
G
-
L
--
L
V
K
K
NH
E
Y
E
I
N
H
V
D
V
A
F
S
A
L
H
G
K
S
G
E
D
G
S
I
Q
G
L
F
E
L
S
G
I
P
F
V
G
C
D
I
Q
S
S
A
I
C
M
D
K
S
L
T
Y
I
V
A
K
N
A
-
G
-
I
A
T
P
A
F
W
---
V
I
N
K
D
---
D
-
R
P
------
V
A
A
T
F
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
K
K
V
N
S
A
D
E
L
D
Y
A
I
E
S
A
R
Q
Y
D
S
K
I
L
I
E
Q
A
V
S
-
G
-
C
E
V
G
C
A
V
L
G
N
S
-----
A
A
------
L
V
V
G
-
E
V
-------
D
-----
Q
I
R
L
Q
Y
G
I
F
R
I
-
H
Q
-
E
-
V
E
PEKGSEN
A
V
I
T
V
P
A
D
L
S
A
E
E
R
G
R
I
Q
E
T
V
K
K
I
Y
K
T
L
G
C
R
G
L
A
R
V
D
M
F
L
Q
D
N
G
R
I
V
L
N
E
V
N
T
L
P
G
F
T
S
Y
S
R
Y
P
R
M
M
A
A
A
G
I
S
L
P
E
L
I
D
R
L
I
V
L
A
L
--------------
94
HHSearch
68.29
38%
-10
- C1 -
-
3RFC
1
?
A:
[21-377]
--
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
-
D
-
P
-
Q
R
F
E
P
V
L
I
G
I
D
K
Q
G
Q
W
-
H
V
N
D
---
P
D
S
F
L
L
H
A
D
DPA
R
I
A
--
L
H
R
--
S
G
-----
R
G
-----
V
A
-
L
L
P
G
AQ
Q
Q
Q
L
R
----
P
I
Q
----
Q
A
L
A
Q
I
-
D
--
V
V
--------------
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
A
-
R
-
L
A
V
A
P
F
V
---
C
F
D
R
H
T
A
A
H
A
D
V
----
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
V--
P
H
-
A
------
S
V
C
G
-
E
V
V
-----
V
------------------------
E
---------
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
-----
61
PsiBlast_CBE
67.70
32%
-29
- C1 -
-
1E4E
8
VANA_ENTFC
B:
[4-341]
--
I
K
V
A
I
L
F
G
G
C
S
E
E
H
D
V
S
V
K
S
A
I
E
I
A
A
N
I
-
N
-
K
-
E
K
Y
E
P
L
Y
I
G
I
T
K
S
G
V
W
--------
K
M
C
E
K
P
C
-
A
----
E
---------------
W
E
----------
N
E
--
N
C
Y
S
A
----
V
L
S
P
--
D
K
-
K
M
H
G
-
L
--
L
V
KKNHEYEINHVDVA
F
S
A
L
H
G
K
S
G
E
D
G
S
I
Q
G
L
F
E
L
S
G
I
P
F
V
G
C
D
I
Q
S
S
A
I
C
M
D
K
S
L
T
Y
I
V
A
K
N
A
-
G
-
I
A
T
P
A
F
W
---
V
I
N
K
D
---
D
-
R
P
------
V
A
A
T
F
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
K
K
V
N
S
A
D
E
L
D
Y
A
I
E
S
A
R
Q
Y
D
S
K
I
L
I
E
Q
A
V
S
-
G
-
C
E
V
G
C
A
V
L
G
N
S
-----
A
A
------
L
V
V
G
-
E
V
-------
D
-----
Q
I
R
L
Q
Y
G
I
F
R
I
-
H
Q
-
E
-
V
E
PEKGSENAV
I
T
V
P
A
D
L
S
A
E
E
R
G
R
I
Q
E
T
V
K
K
I
Y
K
T
L
G
C
R
G
L
A
R
V
D
M
F
L
Q
D
R
G
R
I
V
L
N
E
V
N
T
L
P
G
F
T
S
Y
S
R
Y
P
R
M
M
A
A
A
G
I
S
L
P
E
L
I
D
R
L
I
V
L
A
L
--------------
73
PsiBlast_CBE
65.79
32%
-49
- C1 -
-
4C5B
3
DDLB_ECOLI
B:
[28-328]
---
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
----------------
R
E
G
G
I
-
D
A
Y
P
---
V
---
D
P
K
-
E
----
V
D
--
V
T
Q
--
L
K
-----------------
S
M
--
G
F
Q
K
-----------------------
V
--------------
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
---
A
L
T
R
A
E
F
E
K
-
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-------------
I
L
P
S
I
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
-
S
D
-
E
-
T
Q
---------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
----------------
72
PsiBlast_CBE
65.21
32%
-47
- C1 -
-
4C5C
5
DDLB_ECOLI
A:
[28-328]
---
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
----------------
R
E
G
G
I
-
D
A
Y
P
---
V
---
D
P
K
-
E
----
V
D
--
V
T
Q
--
L
K
-----------------
S
M
--
G
F
Q
K
-----------------------
V
--------------
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
---
A
L
T
R
A
E
F
E
K
-
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-------------
I
L
P
S
I
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
-
S
D
-
E
-
T
Q
---------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
----------------
77
PsiBlast_CBE
65.16
32%
-52
- C1 -
-
1IOW
2
DDLB_ECOLI
A:
[4-304]
---
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
----------------
R
E
G
G
I
-
D
A
Y
P
---
V
---
D
P
K
-
E
----
V
D
--
V
T
Q
--
L
K
-----------------
S
M
--
G
F
Q
K
-----------------------
V
--------------
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
---
A
L
T
R
A
E
F
E
K
-
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-------------
I
L
P
S
I
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
F
L
-
S
D
-
E
-
T
Q
---------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
----------------
76
PsiBlast_CBE
65.03
32%
-51
- C1 -
-
4C5A
4
DDLB_ECOLI
A:
[28-328]
---
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
----------------
R
E
G
G
I
-
D
A
Y
P
---
V
---
D
P
K
-
E
----
V
D
--
V
T
Q
--
L
K
-----------------
S
M
--
G
F
Q
K
-----------------------
V
--------------
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
---
A
L
T
R
A
E
F
E
K
-
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-------------
I
L
P
S
I
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
-
S
D
-
E
-
T
Q
---------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
----------------
74
PsiBlast_CBE
64.82
32%
-49
- C1 -
-
4C5B
6
DDLB_ECOLI
A:
[28-328]
---
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
----------------
R
E
G
G
I
-
D
A
Y
P
---
V
---
D
P
K
-
E
----
V
D
--
V
T
Q
--
L
K
-----------------
S
M
--
G
F
Q
K
-----------------------
V
--------------
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
---
A
L
T
R
A
E
F
E
K
-
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-------------
I
L
P
S
I
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
-
S
D
-
E
-
T
Q
---------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
----------------
75
PsiBlast_CBE
64.06
32%
-50
- C1 -
-
4C5A
2
DDLB_ECOLI
B:
[28-328]
---
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
----------------
R
E
G
G
I
-
D
A
Y
P
---
V
---
D
P
K
-
E
----
V
D
--
V
T
Q
--
L
K
-----------------
S
M
--
G
F
Q
K
-----------------------
V
--------------
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
---
A
L
T
R
A
E
F
E
K
-
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-------------
I
L
P
S
I
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
-
S
D
-
E
-
T
Q
---------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
----------------
39
PsiBlast_CBE
64.04
34%
-10
- C1 -
-
5C1P
4
DDL_YERPE
D:
[4-304]
---
K
V
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
L
S
G
Q
A
V
L
A
G
L
----------------
K
E
------------------------------------------------
A
G
I
D
A
Y
--
G
V
D
T
K
----
D
F
P
V
--
T
Q
L
K
E
Q
G
F
D
--
K
V
--------------
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
V
L
E
F
L
Q
L
P
Y
T
G
S
G
V
M
A
S
A
L
T
M
D
K
L
R
T
K
L
V
W
Q
A
L
-
G
-
L
P
I
S
P
Y
V
---
A
L
N
R
Q
Q
F
E
T
-
L
S
P
E
E
L
V
A
C
V
A
K
L
G
L
P
L
I
V
K
P
S
H
E
---
V
G
M
S
K
V
D
H
A
S
E
L
Q
K
A
L
V
E
A
F
Q
H
D
S
D
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
D
E
V
L
P
S
I
R
I
------
Q
P
P
G
-----------------
V
F
Y
D
Y
D
A
K
Y
L
-
S
D
-
K
-
T
Q
---------
Y
F
C
P
S
G
L
S
D
E
S
E
Q
Q
L
A
A
L
A
L
Q
A
Y
H
A
L
D
C
S
G
W
G
R
V
D
V
M
Q
D
R
D
G
H
F
Y
L
L
E
V
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
Y
G
L
S
F
S
Q
L
V
A
R
I
L
M
L
----------------
71
PsiBlast_CBE
63.89
32%
-45
- C1 -
-
4C5C
3
DDLB_ECOLI
B:
[28-328]
---
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
----------------
R
E
G
G
I
-
D
A
Y
P
---
V
---
D
P
K
-
E
----
V
D
--
V
T
Q
--
L
K
-----------------
S
M
--
G
F
Q
K
-----------------------
V
--------------
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
---
A
L
T
R
A
E
F
E
K
-
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-------------
I
L
P
S
I
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
-
S
D
-
E
-
T
Q
---------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
----------------
90
HHSearch
63.14
33%
15
- C1 -
-
1EHI
2
DDL_LEUMM
A:
[4-357]
--
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
N
A
I
-
E
A
T
-
G
K
Y
E
I
I
V
F
A
I
A
Q
N
G
F
F
-
L
D
T
E
---
S
S
K
K
I
L
A
-
L
----
E
D
--
E
Q
P
I
V
D
A
-----
F
M
-----
K
T
--
V
D
A
--
S
D
P
L
A
----
R
I
H
A
--
L
K
S
A
G
D
F
-
D
--
I
F
--------------
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
T
V
N
-
G
-
I
R
N
T
K
Y
I
---
V
V
D
P
E
S
A
N
N
----
W
S
W
D
K
I
V
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
-
G
A
R
E
L
E
V
G
V
I
G
N
D
---
Q
P
L
V
------
S
E
I
G
-
A
H
T
-----
V
P
NQGSG
D
G
W
Y
D
Y
N
N
K
F
V
-
D
N
-
S
A
V
H
---------
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
---------
70
PsiBlast_CBE
62.47
32%
-45
- C1 -
-
1IOV
2
DDLB_ECOLI
A:
[4-304]
---
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
----------------
R
E
G
G
I
-
D
A
Y
P
---
V
---
D
P
K
-
E
----
V
D
--
V
T
Q
--
L
K
-----------------
S
M
--
G
F
Q
K
-----------------------
V
--------------
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
---
A
L
T
R
A
E
F
E
K
-
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-------------
I
L
P
S
I
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
-
S
D
-
E
-
T
Q
---------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
----------------
69
PsiBlast_CBE
62.26
32%
-49
- C1 -
-
2DLN
2
DDLB_ECOLI
A:
[4-304]
---
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
----------------
R
E
G
G
I
-
D
A
Y
P
---
V
---
D
P
K
-
E
----
V
D
--
V
T
Q
--
L
K
-----------------
S
M
--
G
F
Q
K
-----------------------
V
--------------
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
---
A
L
T
R
A
E
F
E
K
-
G
L
S
D
K
Q
L
A
E
I
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
-------------
I
L
P
S
I
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
-
S
D
-
E
-
T
Q
---------
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
----------------
110
Fugue
59.64
32%
29
- C1 -
-
1EHI
2
DDL_LEUMM
A:
[3-362]
-K
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
N
A
I
-
E
-
A
T
G
K
Y
E
I
I
V
F
A
I
A
Q
N
G
F
F
-
L
D
T
E
---
S
S
K
K
I
L
A
-
L
----
E
D
--
E
Q
P
--
I
V
-----
D
A
-----
F
M
K
T
V
D
A
--
S
D
P
L
A
----
R
I
H
A
--
L
K
S
A
G
D
F
-
D
--
I
F
--------------
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
T
V
N
-
G
-
I
R
N
T
K
Y
I
---
V
V
D
P
E
S
A
N
N
-
W
S
---
W
D
K
I
V
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
G
A
-
R
E
L
E
V
G
V
I
G
N
D
---
Q
P
L
V
------
S
E
I
G
-
A
H
T
V
P
NQG
S
G
-----
D
G
W
Y
D
Y
N
N
K
F
V
-
D
N
S
A
-
V
H
---------
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
----
38
PsiBlast_CBE
58.77
33%
19
- C1 -
-
1EHI
2
DDL_LEUMM
A:
[5-359]
---
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
N
A
I
E
A
-
T
-
G
K
Y
E
I
I
V
F
A
I
A
Q
N
G
----------
F
F
L
D
T
E
S
-
S
----
K
K
--
I
L
A
--
L
E
DE
Q
P
I
V
D
-----
A
F
M
K
T
V
D
--
A
-
S
D
P
----
L
A
R
I
--
H
A
L
K
S
A
G
-
D
FD
I
F
--------------
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
T
V
N
-
G
-
I
R
N
T
K
Y
I
V
V
D
P
E
S
A
N
N
W
S
-------
W
D
K
I
V
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
G
A
-
R
E
L
E
V
G
V
I
G
N
D
---
Q
P
L
V
S
E
I
G
A
H
T
V
P
N
-
Q
G
S
-----
G
D
------
G
W
Y
D
Y
N
N
K
F
V
-
D
N
-
S
A
V
H
---------
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
-------
112
Fugue
42.03
33%
-9
- C1 -
-
1EHI
2
DDL_LEUMM
A:
[135-362]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
A
L
T
K
E
L
L
T
V
N
-
G
-
I
R
N
T
K
Y
I
---
V
V
D
P
E
S
A
N
N
--
W
S
--
W
D
K
I
V
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
G
A
-
R
E
L
E
V
G
V
I
G
N
D
---
Q
P
L
V
------
S
E
I
G
-
A
H
T
V
P
NQG
S
G
-----
D
G
W
Y
D
Y
N
N
K
F
V
D
N
S
-
A
-
V
H
---------
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
----
114
Fugue
27.67
42%
-14
- C1 -
-
1IOW
1
?
?:
[1-96]
M
T
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
-
R
-
E
-
G
G
I
D
A
Y
P
V
----------------------------------------------
D
-----
P
K
E
V
D
V
T
--
Q
L
K
---------------
S
M
G
F
-
Q
--
K
V
--------------
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------