@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXL0: (2018-01-04 )
MKFKELELSPELLKSVERAGFEEATPIQAETIPLALAGKDVIGQAQTGTGKTAAFGLPMLEKIDPDRHELQGLVIAPTRELAIQTQEELYRLGRDKKVRVQAVYGGADIGRQIRGLKDRPHIVVGTPGRMLDHINRHTLKLGTVQTLVLDEADEMLNMGFLEDIEKIISQVPDQRQTLLFSATMPPAIKNIGVKFMKNPHHVKIKAKEMTADLIDQYYVRAKEYEKFDIMTRLFDVQTPELTIVFGRTKRRVDELARGLEARGYRAEGIHGDLSQQKRMSVLRSFKSGHLDILVATDVAARGLDISGVTHVYNYDIPQDPESYVHRIGRTGRAGKGGMSVTFVTPNEMDYLHVIENLTKKRMTTLRPPTEKEAFKGQLGAAVEQIETKLAENGLDKYLQTADKLLEEYSAQDLVALLLKTTAKDPADAVPVKITPERPLPMQKKGYNKNGKRGGGNNRNRRDGGNYRGNKSKGGYSKNNNSQKDGGKRHNDKKRGFVIRSNND
Atome Classification :
(36 SA)
.........10........20........30........40........50........60......---------.---.70--------.........80........90.....-...100.......110.......120.......130.......140.......150.......160.......170---.----.......180.......190.......200.......210.......220.-...-....230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKFKELEL
S
P
E
L
L
K
S
V
E
RAGFEEATPIQAET
I
P
L
A
LAGKDVIGQAQTGTGKTAAFGL
P
M
L
E
KIDP
D
R
---------
H
---EL---------Q
G
L
V
IAP
T
R
E
L
A
I
Q
T
Q
E
E
L
Y
R
LGRD
K
-
K
V
R
V
Q
A
V
YGG
A
D
I
G
R
Q
I
RGLKDRP
H
I
V
VGT
P
G
R
M
L
D
H
INRH
T
L
KLG
T
V
Q
T
L
VLD
E
A
D
E
M
L
N
M
G
F
L
E
D
I
E
K
I
I
S
QV----P----DQR
Q
T
L
L
F
SATMP
P
A
I
K
N
I
G
V
K
FMKNP
H
H
V
K
I
K
A
K
E
M
T
A
D
L
I
D
Q
Y
Y
V
R
A
-
K
-
E
Y
E
-
K
F
D
I
M
T
R
L
FDVQTP
E
L
T
I
V
FG
R
T
K
R
R
V
D
E
L
A
R
G
L
E
ARGYRAEGIHG
D
L
S
Q
Q
K
R
M
S
V
L
R
S
FKSG
H
L
D
I
L
V
ATDVAARGLDISG
V
T
H
V
Y
NYDIPQD
P
E
S
Y
V
H
R
IGRTGRAGKG
G
M
S
V
T
F
VTPNE
M
D
Y
L
H
V
I
E
N
L
T
K
K
R
MTTLRPP
T
E
K
E
A
F
K
G
Q
L
G
A
A
V
E
Q
I
E
T
K
L
A
E
N
G
L
D
K
Y
L
Q
T
A
D
K
L
L
E
E
Y
S
A
Q
D
L
V
A
L
L
L
K
TTAKDPADAV
P
V
K
ITPERPLPMQKKGYNKNGKRGGGNNRNRRDGGNYRGNKSKGGYSKNNNSQKDGGKRHNDKKR
G
F
V
I
RSNND
134
HHSearch
87.70
64%
-95
- C3 -
-
5IVL
-
?
B:
[4-423]
--
F
Q
E
L
G
L
S
Q
E
V
M
K
A
I
E
R
M
G
F
E
E
T
T
P
I
Q
A
K
T
I
P
L
S
L
Q
N
K
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
I
V
E
K
V
D
V
K
N
---------
G
---
A
I
---------
Q
A
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
L
Y
K
I
G
A
V
K
-
R
V
R
V
L
P
I
Y
G
G
Q
D
I
E
R
Q
I
R
A
L
K
K
H
P
H
V
I
V
G
T
P
G
R
I
I
D
H
I
N
R
G
T
L
R
L
E
H
V
H
T
V
V
L
D
E
A
D
E
M
L
--
G
F
I
E
D
I
E
A
I
L
S
H
V
----
P
----
A
E
R
Q
T
L
L
F
S
A
T
M
P
D
P
I
R
R
I
A
E
R
F
M
N
E
P
E
L
V
K
V
K
A
----
V
P
N
I
Q
Q
Y
Y
L
E
V
-
H
-
E
K
K
-
K
F
D
I
L
T
R
L
L
D
I
Q
A
P
E
L
A
I
V
F
G
R
T
K
R
R
V
D
E
L
A
E
A
L
N
L
R
G
Y
A
A
E
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
Q
D
P
E
S
Y
V
H
R
I
G
R
T
G
R
A
G
K
T
G
V
A
M
T
F
V
T
P
R
E
I
G
Q
L
H
H
I
E
R
T
T
K
R
K
M
E
R
M
K
P
P
T
L
D
E
A
L
E
G
Q
Q
R
I
A
I
E
K
L
L
N
V
V
E
T
E
---
F
Y
K
R
A
A
E
E
L
L
E
E
H
D
S
V
T
I
V
A
A
C
L
K
M
L
E
---------------------------------------------------------------------------------
1
PsiBlast_PDB
86.96
64%
-96
- C3 -
-
5IVL
-
?
B:
[4-420]
--
F
Q
E
L
G
L
S
Q
E
V
M
K
A
I
E
R
M
G
F
E
E
T
T
P
I
Q
A
K
T
I
P
L
S
L
Q
N
K
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
I
V
E
K
V
D
V
K
N
---------
G
---
A
I
---------
Q
A
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
L
Y
K
I
G
A
V
K
-
R
V
R
V
L
P
I
Y
G
G
Q
D
I
E
R
Q
I
R
A
L
K
K
H
P
H
V
I
V
G
T
P
G
R
I
I
D
H
I
N
R
G
T
L
R
L
E
H
V
H
T
V
V
L
D
E
A
D
E
M
L
--
G
F
I
E
D
I
E
A
I
L
S
H
V
----
P
----
A
E
R
Q
T
L
L
F
S
A
T
M
P
D
P
I
R
R
I
A
E
R
F
M
N
E
P
E
L
V
K
V
K
A
----
V
P
N
I
Q
Q
Y
Y
L
E
V
-
H
-
E
K
K
-
K
F
D
I
L
T
R
L
L
D
I
Q
A
P
E
L
A
I
V
F
G
R
T
K
R
R
V
D
E
L
A
E
A
L
N
L
R
G
Y
A
A
E
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
Q
D
P
E
S
Y
V
H
R
I
G
R
T
G
R
A
G
K
T
G
V
A
M
T
F
V
T
P
R
E
I
G
Q
L
H
H
I
E
R
T
T
K
R
K
M
E
R
M
K
P
P
T
L
D
E
A
L
E
G
Q
Q
R
I
A
I
E
K
L
L
N
V
V
E
T
E
---
F
Y
K
R
A
A
E
E
L
L
E
E
H
D
S
V
T
I
V
A
A
C
L
K
------------------------------------------------------------------------------------
145
HHSearch
73.93
38%
-122
- C3 -
-
1S2M
-
DHH1_YEAST
A:
[47-403]
-
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
K
P
K
L
---------
N
---
K
I
---------
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
C
-
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
K
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
D
F
K
T
I
I
E
Q
I
L
S
F
L
----
P
----
P
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
N
L
M
E
E
L
-
T
L
K
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
R
Q
-
K
L
H
C
L
N
T
L
F
S
K
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
F
N
L
Y
K
I
E
Q
E
L
G
------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.15
38%
-125
- C3 -
-
1S2M
-
DHH1_YEAST
A:
[48-399]
--
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
K
P
K
L
---------
N
---
K
I
---------
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
C
-
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
K
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
D
F
K
T
I
I
E
Q
I
L
S
F
L
----
P
----
P
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
N
L
-
M
E
E
L
T
L
K
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
R
Q
-
K
L
H
C
L
N
T
L
F
S
K
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
F
N
L
Y
K
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.21
40%
-83
- C3 -
-
3EX7
3
IF4A3_HUMAN
C:
[40-393]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
V
---------
R
---
E
T
---------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
-
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
L
----
P
----
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
E
W
-
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.08
40%
-80
- C3 -
-
2J0S
2
IF4A3_HUMAN
A:
[39-392]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
V
---------
R
---
E
T
---------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
-
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
L
----
P
----
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
E
W
-
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.65
40%
-78
- C3 -
-
2J0Q
2
IF4A3_HUMAN
A:
[39-392]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
V
---------
R
---
E
T
---------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
-
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
L
----
P
----
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
E
W
-
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
71.58
40%
-79
- C3 -
-
2XB2
1
IF4A3_HUMAN
X:
[40-393]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
V
---------
R
---
E
T
---------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
-
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
L
----
P
----
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
E
W
-
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.32
40%
-81
- C3 -
-
2HYI
2
IF4A3_HUMAN
C:
[40-393]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
V
---------
R
---
E
T
---------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
-
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
L
----
P
----
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
E
W
-
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.18
40%
-78
- C3 -
-
2J0Q
2
IF4A3_HUMAN
B:
[39-392]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
V
---------
R
---
E
T
---------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
-
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
L
----
P
----
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
E
W
-
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.10
37%
-128
- C3 -
-
4BRU
-
DHH1_YEAST
A:
[48-399]
--
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
K
P
K
L
---------
N
---
K
I
---------
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
C
-
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
K
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
D
F
K
T
I
I
E
Q
I
L
S
F
L
----
P
----
P
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
-
M
E
E
L
T
L
K
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
R
Q
-
K
L
H
C
L
N
T
L
F
S
K
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
F
N
L
Y
K
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.09
40%
-77
- C3 -
-
2XB2
1
IF4A3_HUMAN
A:
[40-393]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
V
---------
R
---
E
T
---------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
-
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
L
----
P
----
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
E
W
-
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
71.05
40%
-78
- C3 -
-
2HYI
2
IF4A3_HUMAN
I:
[40-393]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
V
---------
R
---
E
T
---------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
-
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
L
----
P
----
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
E
W
-
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
71.03
40%
-77
- C3 -
-
3EX7
3
IF4A3_HUMAN
H:
[40-393]
--
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
V
---------
R
---
E
T
---------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
-
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
L
----
P
----
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
-
E
E
W
-
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
150
HHSearch
70.99
40%
-93
- C3 -
-
1FUU
-
IF4A_YEAST
B:
[22-376]
-
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
D
T
S
V
---------
K
---
A
P
---------
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
-
D
I
K
V
H
A
C
I
G
G
T
S
F
V
E
D
A
E
G
-
L
R
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
R
R
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
S
G
F
K
E
Q
I
Y
Q
I
F
T
L
L
----
P
----
P
T
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
-
E
E
E
E
Y
-
K
Y
E
C
L
T
D
L
Y
D
S
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
N
Y
I
H
R
I
G
R
G
G
----
K
G
V
A
I
N
F
V
T
N
E
D
V
G
A
M
R
E
L
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
70.99
39%
-87
- C3 -
-
2VSX
1
IF4A_YEAST
B:
[23-386]
-
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
D
T
S
V
---------
K
---
A
P
---------
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
-
D
I
K
V
H
A
C
I
G
----------
L
R
D
-
A
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
R
R
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
S
G
F
K
E
Q
I
Y
Q
I
F
T
L
L
----
P
----
P
T
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
-
E
-
E
E
E
Y
K
Y
E
C
L
T
D
L
Y
D
S
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
70.99
39%
-86
- C3 -
-
2VSX
1
IF4A_YEAST
A:
[23-386]
-
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
D
T
S
V
---------
K
---
A
P
---------
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
-
D
I
K
V
H
A
C
I
G
----------
L
R
D
-
A
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
R
R
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
S
G
F
K
E
Q
I
Y
Q
I
F
T
L
L
----
P
----
P
T
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
-
E
-
E
E
E
Y
K
Y
E
C
L
T
D
L
Y
D
S
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.97
37%
-132
- C3 -
-
4BRW
2
DHH1_YEAST
A:
[3-354]
--
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
K
P
K
L
---------
N
---
K
I
---------
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
C
-
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
K
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
D
F
K
T
I
I
E
Q
I
L
S
F
L
----
P
----
P
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
-
M
E
E
L
T
L
K
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
R
Q
-
K
L
H
C
L
N
T
L
F
S
K
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
F
N
L
Y
K
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
70.90
39%
-88
- C3 -
-
2VSO
1
IF4A_YEAST
B:
[23-386]
-
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
D
T
S
V
---------
K
---
A
P
---------
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
-
D
I
K
V
H
A
C
I
G
----------
L
R
D
-
A
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
R
R
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
S
G
F
K
E
Q
I
Y
Q
I
F
T
L
L
----
P
----
P
T
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
-
E
-
E
E
E
Y
K
Y
E
C
L
T
D
L
Y
D
S
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.56
39%
-88
- C3 -
-
2VSO
1
IF4A_YEAST
A:
[23-386]
-
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
D
T
S
V
---------
K
---
A
P
---------
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
-
D
I
K
V
H
A
C
I
G
----------
L
R
D
-
A
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
R
R
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
S
G
F
K
E
Q
I
Y
Q
I
F
T
L
L
----
P
----
P
T
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
-
E
-
E
E
E
Y
K
Y
E
C
L
T
D
L
Y
D
S
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
------------------------------------------------------------------------------------------------------------------------------------------
141
HHSearch
68.13
39%
-8
- C3 -
-
4D26
2
?
A:
[51-409]
-
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
P
K
D
L
I
S
E
NG
C
A
---
Q
P
---------
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
S
-
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
F
M
P
S
I
E
K
M
M
L
H
P
TMVE
T
----
T
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
-
T
-
K
Y
E
-
K
R
N
S
L
K
Q
L
I
E
E
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
67.62
38%
-11
- C3 -
-
4D26
2
?
A:
[51-404]
-
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
P
---------
K
---
D
L
I
S
E
NG
C
A
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
S
-
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
F
M
P
S
I
E
K
M
M
L
H
P
----
T
MVET
T
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
-
T
-
K
Y
E
-
K
R
N
S
L
K
Q
L
I
E
E
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
67.50
39%
-2
- C3 -
-
4D25
3
?
A:
[51-409]
-
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
P
KD
L
I
S
E
NG
C
A
---
Q
P
---------
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
S
-
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
F
M
P
S
I
E
K
M
M
L
H
P
TMVE
T
----
T
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
-
T
-
K
Y
E
-
K
R
N
S
L
K
Q
L
I
E
E
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
66.97
38%
-6
- C3 -
-
4D25
3
?
A:
[51-404]
-
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
P
---------
K
---
D
L
I
S
E
NG
C
A
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
S
-
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
F
M
P
S
I
E
K
M
M
L
H
P
----
T
MVET
T
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
-
T
-
K
Y
E
-
K
R
N
S
L
K
Q
L
I
E
E
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
65.01
39%
12
- C3 -
-
2DB3
2
VASA1_DROME
D:
[58-406]
--
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
---------
H
---
E
L
ELGRP----
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
S
-
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
G
F
S
E
D
M
R
R
I
M
T
H
V
----
T
MR--
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
-
N
-
K
Y
A
-
K
R
S
K
L
I
E
I
L
S
E
Q
A
-
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.45
39%
12
- C3 -
-
2DB3
2
VASA1_DROME
A:
[58-406]
--
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
---------
H
---
E
L
E
L
GRP----
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
S
-
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
G
F
S
E
D
M
R
R
I
M
T
H
V
----
T
MR--
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
-
N
-
K
Y
A
-
K
R
S
K
L
I
E
I
L
S
E
Q
A
-
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
64.37
39%
19
- C3 -
-
2DB3
2
VASA1_DROME
A:
[57-408]
-
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
H
E
L
E
L
----
G
---
R
P
---------
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
S
-
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
G
F
S
E
D
M
R
R
I
M
T
H
V
----
T
MR--
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
-
N
-
K
Y
A
-
K
R
S
K
L
I
E
I
L
S
E
-
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
63.33
39%
14
- C3 -
-
2DB3
2
VASA1_DROME
C:
[58-406]
--
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
---------
H
---
E
L
ELGRP----
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
S
-
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
G
F
S
E
D
M
R
R
I
M
T
H
V
----
T
MR--
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
-
N
-
K
Y
A
-
K
R
S
K
L
I
E
I
L
S
E
Q
A
-
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
63.23
39%
12
- C3 -
-
2DB3
2
VASA1_DROME
B:
[58-406]
--
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
---------
H
---
E
L
ELGRP----
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
S
-
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
G
F
S
E
D
M
R
R
I
M
T
H
V
----
T
MR--
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
-
N
-
K
Y
A
-
K
R
S
K
L
I
E
I
L
S
E
Q
A
-
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
52.42
46%
-25
- C3 -
-
3NBF
2
?
A:
[1-205]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
Q
---------
E
RGR
K
P
---------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
--
P
-
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
G
F
E
E
E
V
E
A
L
L
S
A
T
----
P
----
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
51.69
46%
-33
- C3 -
-
3NBF
2
?
D:
[1-205]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
K
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
Q
---------
E
RGR
K
P
---------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
--
P
-
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
G
F
E
E
E
V
E
A
L
L
S
A
T
----
P
----
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
50.99
46%
-29
- C3 -
-
3NBF
4
?
C:
[1-205]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
Q
---------
E
RG
R
K
P
---------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
--
P
-
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
G
F
E
E
E
V
E
A
L
L
S
A
T
----
P
----
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
50.81
47%
-27
- C3 -
-
2GXS
2
?
B:
[1-205]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
Q
---------
E
RGR
K
P
---------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
--
P
-
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
G
F
E
E
E
V
E
A
L
L
S
A
T
----
P
----
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
50.29
46%
-26
- C3 -
-
3NBF
2
?
B:
[2-205]
-
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
Q
---------
E
RGR
K
P
---------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
--
P
-
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
G
F
E
E
E
V
E
A
L
L
S
A
T
----
P
----
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
49.27
38%
-67
- C3 -
-
1VEC
1
DDX6_HUMAN
B:
[4-205]
-
E
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
G
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
D
L
K
K
---------
D
---
N
I
---------
Q
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
D
D
T
V
H
V
V
I
A
T
P
G
R
I
L
D
L
I
K
K
G
V
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
Q
D
F
V
Q
I
M
E
D
I
I
L
T
L
----
P
----
K
N
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
E
K
P
Y
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
PsiBlast_CBE
25.34
42%
-126
- C3 -
-
4DB2
4
MS116_YEAST
C:
[66-153]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
L
P
F
V
R
E
L
E
D
---------------------------------------------------------------------------------------------------------------------------------------------------