@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXS4: (2018-01-05 )
MTKLSEMLQETTQFILDKGVKEIDFGLILGSGLGELADEIEDAVMISYDEIPFFPVSTVVGHAGKLVYGSLAGKKVLAMQGRFHYYEGHSMQTVTYPVRVMAGLGAHSVIVTNACGGVNESFVPGDLMLITDHINFTGENPLIGPNEDAMGPRFPDMSQAYTPDYQATAKAAAEKLGLDLKEGVYMGYSGPTYETPAEIRMSRTIGADAVGMSTVPEVIVAAHSGLKVLGISCITNLAAGMQANLSHEEVVETTQRVKQSFKALVKETLTLL
Atome Classification :
(52 SA)
.........10........-20........30........40..-......50........60........70........80........90........100.......110.......120.......130...---..---.---.---140.......150.......160.......-170.....--.--.--180.........190.......200.......210.......220.......230....-----------------...-240-..---...---....250.-.....--.260.......270
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
K
L
S
E
M
L
Q
E
T
T
Q
F
I
L
D
KG-
V
K
EID
F
G
L
I
L
G
S
G
L
G
E
L
A
D
E
I
E
D
A
-
V
M
I
SYDEIP
F
F
P
V
S
T
V
VGHAGK
L
V
Y
GSLAG
K
K
V
L
A
MQ
G
R
F
H
Y
YEGH
S
M
Q
T
V
T
Y
P
V
R
V
M
AGLGA
H
S
V
I
V
TNACGGVNESFVPG
D
L
M
L
I
T
DHIN---FT---G---E---NPLIGPNEDAMGPRFPD
M
S
QAYTP
D
Y
Q
A
T
A
-
K
A
A
A
E
K
LG--
L
--
D
--
L
--
K
E
G
V
Y
MGYSGPTYET
P
A
E
I
R
M
S
RTIGADAVG
M
S
T
V
P
E
V
I
V
A
A
HSG
L
K
V
L
G
I
S
C
I
T
N
-----------------
L
A
A
-
G
---MQ---ANL---
S
H
E
E
V
V
E
T
-
T
Q
R
V
K
--
Q
S
F
K
A
L
V
K
E
T
L
TLL
116
HHSearch
96.46
64%
-126
- C4 -
-
3LBA
1
?
A:
[36-303]
--
S
L
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
-
V
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
A
-
L
V
L
N
Y
A
D
I
P
N
W
G
R
S
------
G
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
G
R
F
H
Y
Y
E
G
N
S
M
E
L
V
T
F
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
G
--
F
G
P
G
T
L
M
A
I
S
D
H
I
N
---
L
T
---
G
---
A
---
N
P
L
M
G
E
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
-
H
Q
V
A
D
K
I
G
--
I
--
K
--
L
--
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
-----------------
Y
A
A
-
G
---
F
Q
---
S
E
L
---
N
---
V
V
A
V
-
T
Q
Q
I
K
--
E
D
F
K
G
L
V
K
A
I
L
V
E
L
2
PsiBlast_PDB
95.85
63%
-127
- C4 -
-
3LBA
1
?
A:
[37-303]
---
L
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
-
V
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
A
-
L
V
L
N
Y
A
D
I
P
N
W
G
R
S
------
G
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
G
R
F
H
Y
Y
E
G
N
S
M
E
L
V
T
F
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
--
G
F
G
P
G
T
L
M
A
I
S
D
H
I
N
---
L
T
---
G
---
A
---
N
P
L
M
G
E
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
-
H
Q
V
A
D
K
I
G
--
I
--
K
--
L
--
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
-----------------
Y
A
A
-
G
---
F
Q
---
S
E
L
---
N
---
V
V
A
V
-
T
Q
Q
I
K
--
E
D
F
K
G
L
V
K
A
I
L
V
E
L
111
HHSearch
92.81
46%
-105
- C4 -
-
4M1E
3
?
D:
[24-295]
-
S
E
L
K
S
R
I
D
Q
A
T
A
K
I
S
Q
L
W
-
Q
G
E
P
A
V
G
M
I
L
G
T
G
L
G
G
L
A
E
Q
I
E
Q
D
-
I
A
I
P
Y
S
D
I
P
H
F
P
T
S
T
V
K
S
H
A
G
R
L
V
C
G
R
L
R
G
I
P
I
V
A
M
E
G
R
F
H
Y
Y
E
G
Y
S
L
E
Q
V
T
F
P
V
R
V
M
K
A
M
G
V
K
T
L
L
V
T
N
A
A
G
G
I
N
P
Q
L
D
L
S
D
V
L
I
I
E
D
H
I
N
---
L
M
---
P
---
E
---
N
P
L
R
G
P
N
D
E
E
L
G
P
R
F
P
D
M
S
H
P
Y
D
C
Q
H
M
E
V
A
-
R
Q
V
A
L
E
L
G
--
I
--
H
--
C
--
P
K
G
V
F
V
A
V
S
G
P
N
L
E
T
R
A
E
Y
R
M
L
K
L
M
G
A
D
V
V
G
M
S
T
V
P
E
V
L
V
A
V
H
A
G
L
R
V
L
G
F
S
V
V
T
D
-----------------
L
C
L
-
P
---
D
A
L--
E
P
V
---
E
L
N
K
I
L
E
V
-
A
A
R
G
G
--
A
K
L
A
R
L
I
P
E
I
L
P
R
I
110
HHSearch
92.43
46%
-108
- C4 -
-
4M1E
3
?
A:
[25-295]
--
E
L
K
S
R
I
D
Q
A
T
A
K
I
S
Q
L
W
-
Q
G
E
P
A
V
G
M
I
L
G
T
G
L
G
G
L
A
E
Q
I
E
Q
D
-
I
A
I
P
Y
S
D
I
P
H
F
P
T
S
T
V
K
S
H
A
G
R
L
V
C
G
R
L
R
G
I
P
I
V
A
M
E
G
R
F
H
Y
Y
E
G
Y
S
L
E
Q
V
T
F
P
V
R
V
M
K
A
M
G
V
K
T
L
L
V
T
N
A
A
G
G
I
N
P
Q
L
D
L
S
D
V
L
I
I
E
D
H
I
N
---
L
M
---
P
---
E
---
N
P
L
R
G
P
N
D
E
E
L
G
P
R
F
P
D
M
S
H
P
Y
D
C
Q
H
M
E
V
A
-
R
Q
V
A
L
E
L
G
--
I
--
H
--
C
--
P
K
G
V
F
V
A
V
S
G
P
N
L
E
T
R
A
E
Y
R
M
L
K
L
M
G
A
D
V
V
G
M
S
T
V
P
E
V
L
V
A
V
H
A
G
L
R
V
L
G
F
S
V
V
T
D
-----------------
L
C
L
-
P
---
D
A
L--
E
P
V
---
E
L
N
K
I
L
E
V
-
A
A
R
G
G
--
A
K
L
A
R
L
I
P
E
I
L
P
R
I
117
HHSearch
91.30
64%
-137
- C4 -
-
3LA8
-
?
A:
[36-303]
--
S
L
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
-
V
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
A
-
L
V
L
N
Y
A
D
I
P
N
W
G
---------
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
-
R
F
H
Y
Y
E
G
-
S
M
E
L
V
T
F
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
G
--
F
G
P
G
T
L
M
A
I
S
D
H
I
N
---
L
T
---
G
---
A
---
N
P
L
M
G
-
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
-
H
Q
V
A
D
K
I
G
--
I
--
K
--
L
--
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
-----------------
Y
A
A
-
G
---
F
---------------
V
A
V
-
T
Q
Q
I
K
--
E
D
F
K
G
L
V
K
A
I
L
V
E
L
1
PsiBlast_PDB
90.78
63%
-139
- C4 -
-
3LA8
-
?
A:
[37-303]
---
L
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
-
V
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
A
-
L
V
L
N
Y
A
D
I
P
N
W
G
---------
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
-
R
F
H
Y
Y
E
G
-
S
M
E
L
V
T
F
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
--
G
F
G
P
G
T
L
M
A
I
S
D
H
I
N
---
L
T
---
G
---
A
---
N
P
L
M
G
-
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
-
H
Q
V
A
D
K
I
G
--
I
--
K
--
L
--
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
-----------------
Y
A
A
-
G
---
F
---------------
V
A
V
-
T
Q
Q
I
K
--
E
D
F
K
G
L
V
K
A
I
L
V
E
L
123
HHSearch
89.94
47%
-98
* C4 *
-
3FUC
2
PNPH_BOVIN
A:
[5-282]
--
Y
T
Y
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
---
G
F
S
G
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
--
E
Q
R
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
ESQ
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
113
HHSearch
89.31
48%
-85
- C4 -
-
4LNA
2
?
A:
[22-293]
--
S
M
F
E
Q
I
Q
E
T
T
Q
F
I
Q
S
K
I
-
T
L
R
P
A
I
G
I
I
L
G
T
G
L
G
A
L
T
N
E
L
D
I
D
-
T
T
I
P
Y
E
T
I
P
H
F
P
L
S
T
V
---
S
G
K
L
L
I
G
T
L
G
G
K
S
V
V
V
M
Q
G
R
F
H
Y
Y
E
G
Y
T
M
Q
Q
V
T
Y
P
V
R
V
M
H
A
L
G
I
Q
T
L
L
V
S
N
A
A
G
G
M
N
P
T
F
Q
T
S
D
L
M
V
I
D
D
H
I
S
---
L
L
L--
P
---
Q
---
N
P
L
I
C
P
N
P
P
I
F
G
D
R
F
P
D
M
S
E
P
Y
R
K
S
L
I
D
L
A
-
F
S
V
A
A
E
L
D
--
I
--
P
--
L
--
K
R
G
V
Y
V
S
V
T
G
P
Q
L
E
T
R
A
E
Y
R
M
L
R
Q
W
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
N
Q
L
G
M
D
V
F
G
I
S
V
I
T
D
-----------------
L
C
F
-
P
---
D
T
L--
E
K
A
---
E
L
V
K
I
L
A
T
-
A
A
Q
A
E
--
P
K
L
T
M
L
I
R
E
M
I
G
R
L
12
PsiBlast_PDB
89.06
48%
-89
- C4 -
-
1B8N
1
PNPH_BOVIN
A:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
Y
-
E
---
S
Q
---
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
118
HHSearch
88.82
47%
-98
- C4 -
-
4NSN
1
?
C:
[25-295]
--
L
Q
E
Q
H
Y
H
E
A
A
S
F
L
S
S
R
L
-
P
G
D
A
K
T
A
I
I
L
G
S
G
L
G
E
L
A
E
K
I
E
N
K
-
T
V
I
P
Y
N
E
I
P
H
F
A
Q
A
T
A
V
G
H
K
G
N
I
I
G
G
I
L
G
G
T
P
V
V
A
M
Q
G
R
F
H
Y
Y
E
G
Y
S
M
D
Q
V
T
F
P
I
R
V
M
K
L
L
G
I
E
N
L
F
V
S
N
A
A
G
G
I
N
T
S
F
K
V
G
D
L
M
I
I
C
D
H
I
N
---
N
L
---
P
-------
N
P
L
I
G
P
N
M
D
M
F
G
V
R
F
P
D
M
T
R
A
Y
D
R
E
F
I
A
K
A
-
K
G
I
A
Q
E
L
N
--
I
--
P
--
V
--
K
E
G
V
Y
V
G
L
T
G
P
S
Y
E
T
P
A
E
Y
K
F
W
G
Q
V
G
G
D
A
I
G
M
S
T
V
P
E
V
I
V
A
R
H
T
G
I
R
V
F
G
M
S
V
I
T
N
-----------------
E
G
Y
-
H
---
F
A
DD-
F
V
N
---
D
E
Q
D
V
I
R
A
-
A
N
A
A
S
--
E
K
M
G
A
I
F
A
R
L
I
A
A
V
8
PsiBlast_PDB
88.45
48%
-86
- C4 -
-
1A9S
1
PNPH_BOVIN
A:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
T
-
E
---
S
Q
---
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
13
PsiBlast_PDB
88.18
48%
-88
- C4 -
-
1B8O
1
PNPH_BOVIN
A:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
Y
-
E
---
S
Q
---
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
7
PsiBlast_PDB
88.18
48%
-87
- C4 -
-
1A9P
1
PNPH_BOVIN
A:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
T
-
E
---
S
Q
---
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
10
PsiBlast_PDB
88.14
48%
-88
- C4 -
-
4PNP
-
PNPH_BOVIN
A:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
T
-
E
---
S
Q
---
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
59
PsiBlast_CBE
88.11
46%
-101
- C4 -
-
3PHB
2
PNPH_HUMAN
S:
[43-310]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
EKA
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
34
PsiBlast_CBE
88.07
46%
-97
- C4 -
-
3K8O
2
PNPH_HUMAN
S:
[8-275]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
EKA
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
5
PsiBlast_PDB
88.07
48%
-88
- C4 -
-
1A9T
2
PNPH_BOVIN
A:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
T
-
E
---
S
Q
---
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
36
PsiBlast_CBE
87.91
46%
-97
- C4 -
-
3K8O
2
PNPH_HUMAN
E:
[8-275]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
EKA
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
15
PsiBlast_PDB
87.90
48%
-100
- C4 -
-
2AI1
2
PNPH_BOVIN
A:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
Y
-
E
---
S
Q
---
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
56
PsiBlast_CBE
87.80
46%
-94
- C4 -
-
3PHB
2
PNPH_HUMAN
Y:
[43-310]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
EKA
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
22
PsiBlast_CBE
87.76
48%
-97
- C4 -
-
3FUC
2
PNPH_BOVIN
B:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
Y
-
E
---
S
Q
---
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
16
PsiBlast_PDB
87.66
48%
-94
- C4 -
-
2AI2
2
PNPH_BOVIN
A:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
Y
-
E
---
S
Q
---
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
21
PsiBlast_CBE
87.56
48%
-98
- C4 -
-
3FUC
2
PNPH_BOVIN
C:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
Y
-
E
---
S
Q
---
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
14
PsiBlast_PDB
87.18
48%
-98
- C4 -
-
3FUC
2
PNPH_BOVIN
A:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
Y
-
E
---
S
Q
---
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
18
PsiBlast_PDB
86.52
48%
-90
- C4 -
-
1FXU
1
PNPH_BOVIN
A:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
T
----------
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
45
PsiBlast_CBE
86.30
46%
-97
- C4 -
-
1RSZ
1
PNPH_HUMAN
A:
[8-275]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
E
K
A
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
47
PsiBlast_CBE
86.14
46%
-98
- C4 -
-
1PF7
1
PNPH_HUMAN
E:
[8-275]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
EKA
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
44
PsiBlast_CBE
86.13
46%
-95
- C4 -
-
1RT9
1
PNPH_HUMAN
A:
[8-275]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
E
K
A
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
46
PsiBlast_CBE
85.99
46%
-94
- C4 -
-
1RR6
1
PNPH_HUMAN
A:
[8-275]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
E
K
A
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
50
PsiBlast_CBE
85.85
46%
-99
- C4 -
-
1V3Q
1
PNPH_HUMAN
E:
[7-274]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
EKA
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
53
PsiBlast_CBE
85.77
46%
-99
- C4 -
-
1RCT
1
PNPH_HUMAN
E:
[7-274]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
EKA
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
17
PsiBlast_PDB
85.60
48%
-98
- C4 -
-
2AI3
2
PNPH_BOVIN
A:
[8-275]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
I
--------------
M
D
Y
-----------
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
39
PsiBlast_CBE
85.41
46%
-95
- C4 -
-
3BGS
1
PNPH_HUMAN
A:
[8-275]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
E
K
A
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
52
PsiBlast_CBE
85.23
46%
-97
- C4 -
-
1RFG
1
PNPH_HUMAN
E:
[7-274]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
EKA
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
75
PsiBlast_CBE
85.19
48%
-93
- C4 -
-
5CXS
1
?
A:
[28-284]
------------------------
D
I
G
I
I
C
G
S
G
L
G
K
L
I
E
E
I
E
E
R
-
K
V
I
P
Y
I
N
I
P
N
F
P
K
T
T
V
A
G
H
V
G
N
L
V
L
G
S
V
G
G
R
K
I
V
A
M
Q
G
R
L
H
M
Y
E
G
Y
S
N
Q
E
I
A
L
P
I
R
V
M
K
L
L
G
V
R
V
L
L
I
T
N
L
A
G
G
I
N
R
K
L
K
S
G
D
F
V
L
I
K
G
H
I
N
---
F
P
---
G
L
G
L
N
---
N
V
L
V
G
P
N
Q
D
E
F
G
P
R
F
P
D
L
S
N
A
Y
D
R
L
L
Q
Q
L
A
L
K
I
A
Q
E
N
D
F
--
Q
--
D
--
L
V
-
H
E
G
V
Y
A
F
N
G
G
P
T
Y
E
S
P
D
E
S
N
M
L
L
K
L
G
C
D
V
V
G
M
S
T
V
P
E
V
I
I
A
C
H
C
G
I
K
V
L
A
V
S
L
I
A
N
N
S
I
--------------
L
D
A
-
E
---
N
D
---
V
S
I
---
N
H
E
K
V
L
A
V
-
A
E
K
R
A
--
D
L
L
Q
M
W
F
K
E
I
I
T
R
L
114
HHSearch
85.12
43%
-96
- C4 -
-
3KHS
1
?
D:
[2-279]
--
T
D
Y
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
-
Q
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
S
-
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
-------
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
N
P
S
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
---
L
P
GLA
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
-
I
S
A
A
R
E
L
G
--
M
--
S
YA
T
--
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
-----------------
V
I
A
-
S
---
N
C
E---------------
A
-
G
E
E
A
S
--
A
R
M
T
A
L
V
K
L
V
I
E
K
I
115
HHSearch
85.02
43%
-87
- C4 -
-
3KHS
2
?
B:
[2-279]
--
T
D
Y
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
-
Q
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
S
-
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
-----
A
G
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
N
P
S
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
---
L
P
G
L
A
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
-
I
S
A
A
R
E
L
G
--
M
--
S
YA
T
--
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
-----------------
V
I
A
-
S
---
N
C
E-----------
E
V
L
R
A
-
G
E
E
A
S
--
A
R
M
T
A
L
V
K
L
V
I
E
K
I
40
PsiBlast_CBE
85.01
46%
-100
- C4 -
-
2Q7O
1
PNPH_HUMAN
E:
[8-275]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
EKA
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
30
PsiBlast_CBE
84.74
46%
-98
- C4 -
-
3K8Q
1
PNPH_HUMAN
A:
[8-275]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
E
K
A
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
48
PsiBlast_CBE
84.29
46%
-97
- C4 -
-
1V45
1
PNPH_HUMAN
E:
[7-274]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
-----------------
K
V
I
-
M
---
D
Y
---
E
S
L
EKA
N
H
E
E
V
L
A
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
29
PsiBlast_CBE
84.23
43%
-100
- C4 -
-
3KHS
2
?
B:
[5-273]
-----
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
-
Q
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
S
-
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
-----
A
G
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
N
P
S
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
L
P
G
L
A
---
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
-
I
S
A
A
R
E
L
G
--
M
--
S
--
Y
A
T
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
-----------------
V
I
A
-
S
NCE--------------
E
V
L
R
A
-
G
E
E
A
S
--
A
R
M
T
A
L
V
K
------
19
PsiBlast_PDB
83.97
48%
-99
- C4 -
-
1VFN
1
PNPH_BOVIN
A:
[5-272]
-----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
-------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
-
H
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI--------------
M
D
------
S
Q
---
G
K
A
---
N
H
E
E
V
L
E
A
-
G
K
Q
A
A
--
Q
K
L
E
Q
F
V
-------
72
PsiBlast_CBE
83.69
47%
-114
- C4 -
-
2ON6
1
PNPH_HUMAN
A:
[8-275]
-----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
----
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
-
L
S
T
W
K
Q
M
G
EQ
R
--
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVIMDYESL
E
K
A
N
F
E
E
V
L
A
A
-
G
---
K
Q
---
A
A
Q
---
K
L
E
Q
F
V
------------------------
28
PsiBlast_CBE
83.67
43%
-102
- C4 -
-
3KHS
2
?
C:
[5-273]
-----
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
-
Q
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
S
-
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
S
----
A
G
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
N
P
S
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
L
P
G
L
A
---
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
-
I
S
A
A
R
E
L
G
--
M
--
S
--
Y
A
T
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
-----------------
V
I
A
-
S
NCE
T
-----------------
A
-
G
E
E
A
S
--
A
R
M
T
A
L
V
K
------
104
PsiBlast_CBE
83.43
45%
-86
- C4 -
-
3FB1
2
?
A:
[28-284]
------------------------
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
K
-
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
---
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
---
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
-
V
Q
V
A
E
E
N
G
--
F
--
G
NL
V
--
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
-----------------
I
S
V
L
D
---
V
E
---
S
D
L
K
P
-
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
---
121
HHSearch
83.33
42%
-99
- C4 -
-
1TCV
2
?
A:
[6-284]
-
T
A
N
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
-
S
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
K
-
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
---
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
---
G
---
L
G
LN
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
-
V
Q
V
A
E
E
N
G
--
F
GN
L
--
V
--
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
-----------------
I
S
V
-
L
---
D
V
ESD---------------
G
A
Q
R
A
--
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
27
PsiBlast_CBE
82.94
43%
-104
- C4 -
-
3KHS
1
?
D:
[5-273]
-----
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
-
Q
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
S
-
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
-------
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
N
P
S
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
LPG
L
A
---
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
-
I
S
A
A
R
E
L
G
--
M
--
S
--
Y
AT
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
-----------------
V
I
A
-
S
NCE------------------
A
-
G
E
E
A
S
--
A
R
M
T
A
L
V
K
------
105
PsiBlast_CBE
82.05
45%
-91
- C4 -
-
3FAZ
2
?
C:
[28-284]
------------------------
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
K
-
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
V
V
G
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
---
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
-
V
Q
V
A
E
E
N
G
--
F
--
G
NL
V
--
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
-----------------
I
S
V
L
D
---
V
E
---
S
D
L
K
P
-
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
---
102
PsiBlast_CBE
81.39
45%
-88
- C4 -
-
3FB1
2
?
C:
[28-284]
------------------------
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
K
-
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
V
V
G
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
---
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
-
V
Q
V
A
E
E
N
G
--
F
--
G
NL
V
--
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
-----------------
I
S
V
L
D
---
V
E
---
S
D
L
K
P
-
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
---
125
HHSearch
77.60
40%
-59
- C4 -
-
1G2O
2
PUNA_MYCTU
A:
[7-268]
--
D
P
D
E
L
A
R
R
A
A
Q
V
I
A
D
R
T
G
I
G
E
H
D
V
A
V
V
L
G
S
G
W
L
P
A
V
A
A
L
G
S
P
T
T
V
L
P
Q
A
E
L
P
G
F
V
P
P
T
A
A
G
H
A
G
E
L
L
S
V
P
I
G
A
H
R
V
L
V
L
A
G
R
I
H
A
Y
E
G
H
D
L
R
Y
V
V
H
P
V
R
A
A
R
A
A
G
A
Q
I
M
V
L
T
N
A
A
G
G
L
R
A
D
L
Q
V
G
Q
P
V
L
I
S
D
H
L
N
---
L
T
---
A
---
R
---
S
P
L
V
G
-------
G
E
F
V
D
L
T
D
A
Y
S
P
R
L
R
E
L
A
-
R
Q
S
D
------
P
--
Q
--
L
--
A
E
G
V
Y
A
G
L
P
G
P
H
Y
E
T
P
A
E
I
R
M
L
Q
T
L
G
A
D
L
V
G
M
S
T
V
H
E
T
I
A
A
R
A
A
G
A
E
V
L
G
V
S
L
V
T
N
-----------------
L
A
A
-
G
---
I
T
G--
E
P
L
---
S
H
A
E
V
L
A
A
-
G
A
A
S
A
--
T
R
M
G
A
L
L
A
D
V
I
A
R
F
103
PsiBlast_CBE
77.00
45%
-91
- C4 -
-
3FB1
2
?
B:
[28-284]
------------------------
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
K
-
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
-
V
V
G
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
---
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
-
V
Q
V
A
E
E
N
G
--
F
--
G
NL
V
--
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
-----------------
I
S
V
L
D
---
V
E
---
S
--------------
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
---
124
HHSearch
76.21
40%
-61
- C4 -
-
1I80
2
PUNA_MYCTU
A:
[7-268]
--
D
P
D
E
L
A
R
R
A
A
Q
V
I
A
D
R
T
G
I
G
E
H
D
V
A
V
V
L
G
S
G
W
L
P
A
V
A
A
L
G
S
P
T
T
V
L
P
Q
A
E
L
P
G
F
V
P
P
T
A
A
G
H
A
G
E
L
L
S
V
P
I
G
A
H
R
V
L
V
L
A
G
R
I
H
A
Y
E
G
H
D
L
R
Y
V
V
H
P
V
R
A
A
R
A
A
G
A
Q
I
M
V
L
T
N
A
A
G
G
L
R
A
D
L
Q
V
G
Q
P
V
L
I
S
D
H
L
N
---
L
T
---
A
---
R
---
S
P
L
V
G
-------
G
E
F
V
D
L
T
D
A
Y
S
P
R
L
R
E
L
A
-
R
Q
S
D
------
P
--
Q
--
L
--
A
E
G
V
Y
A
G
L
P
G
P
H
Y
E
T
P
A
E
I
R
M
L
Q
T
L
G
A
D
L
V
G
M
S
T
V
H
E
T
I
A
A
R
A
A
G
A
E
V
L
G
V
S
L
V
T
N
-----------------
L
A
A
-
G
---
I
T
G--
E
P
L
---
S
H
A
E
V
L
A
A
-
G
A
A
S
A
--
T
R
M
G
A
L
L
A
D
V
I
A
R
F