@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXT0: (2018-01-05 )
MNNFDIFRFKPFINEALTAKGFKQPTEVQERLIPLIAKGKNIIGQSQTGTGKTHTFLLPLFEKINAEKEEVQVVITAPSRELAAQIYEAATQIAKFSTPEIRVSNFVGGTDKQRQLNRLHHQQPQVVVGTPGRILDMMNEQALKIHTAFAFVVDEADMTLDMGFLNEVDQIASRLPEKLQFLVFSATIPEKLRPFLRKYMENPIIEEIKPKAVISEDIENWLISTKGKDENQMIYQLLTIGHPYLAIVFANTKQHVDEIADYLKNQGLKVAKIHGDITPRERKRVMRQVQNLEYQYVVATDLAARGIDIEGVSHVINAEIPEDLDFFIHRVGRTGRNGLKGTAITLYSPNDEQAIDAIEKLGVSFEPKEIKNGEIVKTYDRNRRAKREKSKDVLDPTLIGLVKKKKKKIKPGYKKKIDWAIAEKNKKERKIERRQQSRTARKNKKNSHK
Atome Classification :
(33 SA)
.........10........20....-----....30.......--.--40........50........60....----..------------------.------------------.---70........80........90......--..100.......110.......120.......130.......140........--150.....-..160........170..----.----...--.180.......190.......200..-.....210...-....220...-...----.230---.......-.240....----....250.......260.......270.......280.......290.......300.......310.......320-----....------....330.......340...-....-350.......---360.......370.......380.......390.......400.......410.......420.......430.......440.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNNF
D
I
F
R
F
K
P
F
I
N
E
A
L
T
AKGFKQ
P
-----
T
E
V
Q
E
R
L
I
P
L
I
AK--G--KNIIGQSQTGTGK
T
H
T
F
L
L
P
L
F
E
K
IN----AE------------------
K
------------------
E
---
E
V
Q
V
V
I
TAP
S
R
E
L
A
A
Q
I
Y
E
A
A
T
Q
I
AKFS--TP
E
I
R
V
SNFVGG
T
D
K
Q
R
Q
L
N
R
L
HHQQP
Q
V
V
VGT
P
G
R
I
L
D
M
M
N
E
-
Q
A
L
K
I
H
T
A
F
--
A
F
V
VDEAD-
M
T
L
D
-
M
G
F
L
N
E
V
D
Q
I
A
S
R
----
L
----
P
E
K
--
L
Q
F
L
VFSATI
P
E
K
L
R
P
F
L
R
K
Y
M
ENP
I
-
I
E
EIKP
K
A
V
I
S
-
E
D
I
E
N
W
L
IST-KGK----D
E
N
----
Q
M
I
Y
Q
L
L
-TI-GH
P
Y
L
----
A
I
V
FAN
T
K
Q
H
V
D
E
I
A
D
Y
L
K
NQG
L
K
V
A
K
IHGDIT
P
R
E
R
K
R
V
M
R
Q
V
QNL
E
Y
Q
Y
V
V
ATDLAARGI
D
I
E
G
V
S
H
V
INAEIP------
E
D
L
D
------
F
F
I
H
R
VGRTGRNGLKG
T
A
I
T
-
L
YSP-N
D
E
Q
A
I
D
A
I
E
---
K
LGVSFE
P
K
EIKNG
E
I
V
K
TYDR
N
R
R
A
K
R
EKSKDVL
D
P
T
L
I
G
L
V
K
K
K
K
K
KIKPGYKKKI
D
W
AIAEK
N
K
K
E
R
K
I
E
R
R
Q
Q
S
R
T
ARKNKKNSHK
1
PsiBlast_PDB
80.01
38%
-109
- C3 -
-
5IVL
-
?
B:
[4-360]
---
F
Q
E
L
G
L
S
Q
E
V
M
K
A
I
E
R
M
G
F
E
E
T
-----
T
P
I
Q
A
K
T
I
P
L
S
L
Q
--
N
--
K
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
I
V
E
K
V
D
----
V
K
------------------
N
------------------
G
---
A
I
Q
A
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
L
Y
K
I
G
--
A
--
V
K
R
V
R
V
L
P
I
Y
G
G
Q
D
I
E
R
Q
I
R
A
L
K
-
K
H
P
H
V
I
V
G
T
P
G
R
I
I
D
H
I
N
R
-
G
T
L
R
L
E
H
V
H
--
T
V
V
L
D
E
A
D
-
E
M
L
---
G
F
I
E
D
I
E
A
I
L
S
H
----
V
----
P
A
E
--
R
Q
T
L
L
F
S
A
T
M
P
D
P
I
R
R
I
A
E
R
F
M
N
E
P
E
-
L
V
K
V
K
A
----
V
-
P
N
I
Q
Q
Y
Y
L
E
V
-
H
E
K
----
K
K
F
----
D
I
L
T
R
L
L
-
D
I
-
Q
A
P
E
L
----
A
I
V
F
G
R
T
K
R
R
V
D
E
L
A
E
A
L
N
L
R
G
Y
A
A
E
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
------
Q
D
P
E
------
S
Y
V
H
R
I
G
R
T
G
R
A
G
K
T
G
V
A
M
T
-
F
V
T
P
-
R
E
I
G
Q
L
H
H
I
E
---
R
-----------------------------------------------------------------------------------------
101
HHSearch
79.27
38%
-109
- C3 -
-
5IVL
-
?
B:
[4-359]
---
F
Q
E
L
G
L
S
Q
E
V
M
K
A
I
E
R
M
G
F
E
E
T
-----
T
P
I
Q
A
K
T
I
P
L
S
L
Q
--
N
--
K
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
I
V
E
K
V
D
----
V
K
------------------
N
------------------
G
---
A
I
Q
A
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
L
Y
K
I
G
A
V
K
----
R
V
R
V
L
P
I
Y
G
G
Q
D
I
E
R
Q
I
R
A
L
-
K
K
H
P
H
V
I
V
G
T
P
G
R
I
I
D
H
I
N
R
-
G
T
L
R
L
E
H
V
H
--
T
V
V
L
D
E
A
D
-
E
M
L
---
G
F
I
E
D
I
E
A
I
L
S
H
----
V
----
P
A
E
--
R
Q
T
L
L
F
S
A
T
M
P
D
P
I
R
R
I
A
E
R
F
M
N
E
P
E
-
L
V
K
V
K
A
----
V
-
P
N
I
Q
Q
Y
Y
L
E
V
-
H
E
K
----
K
K
F
----
D
I
L
T
R
L
L
-
D
I
-
Q
A
P
E
L
----
A
I
V
F
G
R
T
K
R
R
V
D
E
L
A
E
A
L
N
L
R
G
Y
A
A
E
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
------
Q
D
P
E
------
S
Y
V
H
R
I
G
R
T
G
R
A
G
K
T
G
V
A
M
T
-
F
V
T
P
-
R
E
I
G
Q
L
H
H
I
E
---------------------------------------------------------------------------------------------
111
HHSearch
78.74
29%
-141
- C3 -
-
4CT4
-
DDX6_HUMAN
B:
[4-360]
G
N
E
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
-----
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
D
----
L
K
------------------
K
------------------
D
---
N
I
Q
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
--
G
-
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
-
D
D
T
V
H
V
V
I
A
T
P
G
R
I
L
D
L
I
K
K
-
G
V
A
K
V
D
H
V
Q
--
M
I
V
L
D
E
A
D
-
K
L
L
S
-
Q
D
F
V
Q
I
M
E
D
I
I
L
T
----
L
----
P
K
N
--
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
-
E
I
N
L
M
E
E
-
L
T
L
-
K
G
V
T
Q
Y
Y
A
Y
V
-
T
E
R
----
Q
K
V
----
H
C
L
N
T
L
F
-
S
R
-
L
Q
I
N
Q
----
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
L
A
E
------
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
-
L
I
T
Y
-
D
D
R
F
N
L
K
S
I
E
---
E
-----------------------------------------------------------------------------------------
113
HHSearch
77.63
30%
-135
- C3 -
-
1S2M
-
DHH1_YEAST
A:
[46-399]
-
N
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
-----
S
P
I
Q
E
E
A
I
P
V
A
I
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
K
----
P
K
------------------
L
------------------
N
---
K
I
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
C
----
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
-
K
V
A
D
L
S
D
C
S
--
L
F
I
M
D
E
A
D
-
K
M
L
S
-
R
D
F
K
T
I
I
E
Q
I
L
S
F
----
L
----
P
P
T
--
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
-
E
I
N
L
M
E
E
-
L
T
L
-
K
G
I
T
Q
Y
Y
A
F
V
-
E
E
R
----
Q
K
L
----
H
C
L
N
T
L
F
-
S
K
-
L
Q
I
N
Q
----
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
T
A
E
------
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
-
L
I
N
W
-
N
D
R
F
N
L
Y
K
I
E
---------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.45
32%
-65
- C3 -
-
3EX7
3
IF4A3_HUMAN
H:
[39-394]
--
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
-----
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
----
I
Q
------------------
V
------------------
R
---
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
--
N
--
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
-
R
S
L
R
T
R
A
I
K
--
M
L
V
L
D
E
A
D
-
E
M
L
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
-
R
I
L
V
K
R
D
E
L
T
L
-
E
G
I
K
Q
F
F
V
A
V
-
E
R
E
EWKF
D
T
L
----
C
D
L
Y
D
T
L
-
T
I
-
T
Q
-------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
-
F
V
K
N
-
D
D
I
R
I
L
R
D
I
E
---
Q
-----------------------------------------------------------------------------------------
25
PsiBlast_CBE
76.02
32%
-62
- C3 -
-
2J0Q
2
IF4A3_HUMAN
B:
[38-393]
--
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
-----
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
----
I
Q
------------------
V
------------------
R
---
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
--
N
--
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
-
R
S
L
R
T
R
A
I
K
--
M
L
V
L
D
E
A
D
-
E
M
L
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
-
R
I
L
V
K
R
D
E
L
T
L
-
E
G
I
K
Q
F
F
V
A
V
-
E
R
E
EWKF
D
T
L
----
C
D
L
Y
D
T
L
-
T
I
-
T
Q
-------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
-
F
V
K
N
-
D
D
I
R
I
L
R
D
I
E
---
Q
-----------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.84
32%
-62
- C3 -
-
2J0Q
2
IF4A3_HUMAN
A:
[38-393]
--
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
-----
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
----
I
Q
------------------
V
------------------
R
---
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
--
N
--
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
-
R
S
L
R
T
R
A
I
K
--
M
L
V
L
D
E
A
D
-
E
M
L
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
-
R
I
L
V
K
R
D
E
L
T
L
-
E
G
I
K
Q
F
F
V
A
V
-
E
R
E
E
W
K
F
D
T
L
----
C
D
L
Y
D
T
L
-
T
I
-
T
Q
-------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
-
F
V
K
N
-
D
D
I
R
I
L
R
D
I
E
---
Q
-----------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.74
32%
-64
- C3 -
-
2J0S
2
IF4A3_HUMAN
A:
[38-393]
--
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
-----
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
----
I
Q
------------------
V
------------------
R
---
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
--
N
--
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
-
R
S
L
R
T
R
A
I
K
--
M
L
V
L
D
E
A
D
-
E
M
L
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
-
R
I
L
V
K
R
D
E
L
T
L
-
E
G
I
K
Q
F
F
V
A
V
-
E
R
E
E
W
K
F
D
T
L
----
C
D
L
Y
D
T
L
-
T
I
-
T
Q
-------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
-
F
V
K
N
-
D
D
I
R
I
L
R
D
I
E
---
Q
-----------------------------------------------------------------------------------------
24
PsiBlast_CBE
75.73
32%
-64
- C3 -
-
2XB2
1
IF4A3_HUMAN
X:
[39-394]
--
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
-----
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
----
I
Q
------------------
V
------------------
R
---
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
--
N
--
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
-
R
S
L
R
T
R
A
I
K
--
M
L
V
L
D
E
A
D
-
E
M
L
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
-
R
I
L
V
K
R
D
E
L
T
L
-
E
G
I
K
Q
F
F
V
A
V
-
E
R
E
EWKF
D
T
L
----
C
D
L
Y
D
T
L
-
T
I
-
T
Q
-------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
-
F
V
K
N
-
D
D
I
R
I
L
R
D
I
E
---
Q
-----------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.64
32%
-67
- C3 -
-
3EX7
3
IF4A3_HUMAN
C:
[39-394]
--
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
-----
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
----
I
Q
------------------
V
------------------
R
---
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
--
N
--
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
-
R
S
L
R
T
R
A
I
K
--
M
L
V
L
D
E
A
D
-
E
M
L
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
-
R
I
L
V
K
R
D
E
L
T
L
-
E
G
I
K
Q
F
F
V
A
V
-
E
R
E
EW
K
F
D
T
L
----
C
D
L
Y
D
T
L
-
T
I
-
T
Q
-------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
-
F
V
K
N
-
D
D
I
R
I
L
R
D
I
E
---
Q
-----------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.54
32%
-64
- C3 -
-
2XB2
1
IF4A3_HUMAN
A:
[39-394]
--
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
-----
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
----
I
Q
------------------
V
------------------
R
---
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
--
N
--
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
-
R
S
L
R
T
R
A
I
K
--
M
L
V
L
D
E
A
D
-
E
M
L
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
-
R
I
L
V
K
R
D
E
L
T
L
-
E
G
I
K
Q
F
F
V
A
V
-
E
R
E
E
W
K
F
D
T
L
----
C
D
L
Y
D
T
L
-
T
I
-
T
Q
-------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
-
F
V
K
N
-
D
D
I
R
I
L
R
D
I
E
---
Q
-----------------------------------------------------------------------------------------
23
PsiBlast_CBE
75.10
32%
-64
- C3 -
-
2HYI
2
IF4A3_HUMAN
I:
[39-394]
--
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
-----
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
----
I
Q
------------------
V
------------------
R
---
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
--
N
--
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
-
R
S
L
R
T
R
A
I
K
--
M
L
V
L
D
E
A
D
-
E
M
L
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
-
R
I
L
V
K
R
D
E
L
T
L
-
E
G
I
K
Q
F
F
V
A
V
-
E
R
E
EWKF
D
T
L
----
C
D
L
Y
D
T
L
-
T
I
-
T
Q
-------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
-
F
V
K
N
-
D
D
I
R
I
L
R
D
I
E
---
Q
-----------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.41
32%
-67
- C3 -
-
2HYI
2
IF4A3_HUMAN
C:
[39-394]
--
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
-----
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
----
I
Q
------------------
V
------------------
R
---
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
--
N
--
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
-
R
S
L
R
T
R
A
I
K
--
M
L
V
L
D
E
A
D
-
E
M
L
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
-
R
I
L
V
K
R
D
E
L
T
L
-
E
G
I
K
Q
F
F
V
A
V
-
E
R
E
E
W
K
F
D
T
L
----
C
D
L
Y
D
T
L
-
T
I
-
T
Q
-------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
-
F
V
K
N
-
D
D
I
R
I
L
R
D
I
E
---
Q
-----------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.55
30%
-69
- C3 -
-
1XTK
1
DX39B_HUMAN
A:
[8-380]
--
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
-----
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
E
----
P
V
------------------
T
------------------
G
---
Q
V
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
---
M
P
N
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
K
K
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
L
A
R
N
-
K
S
L
N
L
K
H
I
K
--
H
F
I
L
D
E
A
D
-
K
M
L
E
Q
L
D
M
R
R
D
V
Q
E
I
F
R
M
----
T
----
P
H
E
--
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
-
E
I
F
V
D
D
E
T
K
L
T
L
H
G
L
Q
Q
Y
Y
V
K
L
-
K
D
N
----
E
K
N
----
R
K
L
F
D
L
L
-
D
V
-
L
E
F
N
Q
----
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
------
E
D
S
D
------
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
-
F
V
S
D
E
N
D
A
K
I
L
N
D
V
Q
D
R
F
E
V
N
I
S
E
L
P
D
E
I
-------------------------------------------------------------------------------
116
HHSearch
71.51
31%
-84
- C3 -
-
2J0U
-
IF4A3_HUMAN
A:
[2-356]
--
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
-----
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
V
S
V
L
Q
C
L
D
----
I
Q
------------------
V
------------------
R
---
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
V
Q
K
G
L
L
A
L
G
D
Y
M
----
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
-
R
S
L
R
T
R
A
I
K
--
M
L
V
L
D
E
A
D
-
E
M
L
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
-
R
I
L
V
K
R
D
E
L
T
L
-
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
----
W
K
F
----
D
T
L
C
D
L
Y
-
D
----
I
T
Q
----
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
--
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
V
N
-
F
V
K
N
-
D
D
I
R
V
L
R
D
I
E
---------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.94
37%
1
- C3 -
-
4KBF
1
?
A:
[2-355]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
-----
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
----
P
S
------------------
Q
------------------
E
RGR
K
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
------
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
-
G
V
L
D
L
S
R
V
E
--
V
A
V
L
D
E
A
D
-
E
M
L
S
-
M
G
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
D
E
P
V
T
Y
-
E
E
-
E
A
V
P
A
P
V
-
R
G
R
----
L
E
------
V
L
S
D
L
L
-
Y
V
-
A
S
P
D
R
----
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
R
A
E
------
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
-
L
Y
G
P
-
R
E
R
R
D
V
E
A
L
E
---
R
-----------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.57
31%
-68
- C3 -
-
2J0U
-
IF4A3_HUMAN
A:
[2-357]
--
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
-----
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
V
S
V
L
Q
C
L
D
----
I
Q
------------------
V
------------------
R
---
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
V
Q
K
G
L
L
A
L
G
D
Y
M
--
N
--
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
-
R
S
L
R
T
R
A
I
K
--
M
L
V
L
D
E
A
D
-
E
M
L
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
-
R
I
L
V
K
R
D
E
L
T
L
-
E
G
I
K
Q
F
F
V
A
V
-
E
R
E
EW
K
F
D
T
L
----
C
D
L
Y
D
----
I
-
T
Q
-------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
--
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
V
N
-
F
V
K
N
-
D
D
I
R
V
L
R
D
I
E
---
Q
-----------------------------------------------------------------------------------------
120
HHSearch
70.15
32%
3
- C3 -
-
2I4I
1
DDX3X_HUMAN
A:
[15-391]
-
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
-----
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
----
S
D
------------------
G
PG
E
A
L
R
A
M
K
E
NGRYGRR
K
Q
---
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
----
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
-
G
K
I
G
L
D
F
C
K
--
Y
L
V
L
D
E
A
D
-
R
M
L
D
-
M
G
F
E
P
Q
I
R
R
I
V
E
Q
----
D
TMPP
K
G
V
--
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
-
F
L
A
V
G
----
T
S
-
E
N
I
T
Q
K
V
V
W
V
-
E
E
S
----
D
K
R
----
S
F
L
L
D
L
L
-
N
A
T
G
K
D
S
L
----
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
-
F
F
N
E
-
R
N
I
N
I
T
K
D
L
----------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.14
32%
-75
- C3 -
-
2HXY
-
IF4A3_HUMAN
A:
[39-394]
--
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
-----
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
----
I
Q
------------------
V
------------------
R
---
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
--
N
--
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
-
R
S
L
R
T
R
A
I
K
--
M
L
V
L
D
E
A
D
-
E
M
L
N
-
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
-
R
I
L
V
K
R
D
E
L
T
L
-
E
G
I
K
Q
F
F
V
A
V
-
E
R
E
EW
K
F
D
T
L
----
C
D
L
Y
D
T
L
-
T
I
-
T
Q
-------
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
-
F
V
K
N
-
D
D
I
R
I
L
R
D
I
E
---
Q
-----------------------------------------------------------------------------------------
36
PsiBlast_CBE
69.67
33%
-74
- C3 -
-
2VSX
1
IF4A_YEAST
A:
[41-378]
--------------------
G
F
E
E
P
-----
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
D
----
T
S
------------------
V
------------------
K
---
A
P
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
----
D
I
K
V
H
A
C
I
G
----------
L
--
R
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
-
R
R
F
R
T
D
K
I
K
--
M
F
I
L
D
E
A
D
-
E
M
L
S
-
S
G
F
K
E
Q
I
Y
Q
I
F
T
L
----
L
----
P
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
-
R
I
L
V
K
K
D
E
L
T
L
-
E
G
I
K
Q
F
Y
V
N
V
--------
E
E
E
----
E
Y
K
Y
E
C
L
-
T
D
-
L
Y
D
S
I
SVT
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
-
F
V
T
N
-
E
D
V
G
A
M
R
E
L
E
---
K
F
----------------------------------------------------------------------------------------
108
HHSearch
69.48
31%
2
- C3 -
-
4D25
3
?
A:
[50-409]
-
E
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
-----
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
----
Q
D
------------------
P
KD
L
I
S
E
NG
C
---------
A
---
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
S
----
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
-
N
R
V
S
F
G
S
V
R
--
F
V
V
L
D
Q
A
D
-
C
M
L
D
-
M
G
F
M
P
S
I
E
K
M
M
L
H
PTMV
E
----
T
T
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
-
F
V
A
V
G
I
V
G
G
A
S
-
T
D
V
E
Q
I
F
I
E
V
-
T
K
Y
----
E
K
R
----
N
S
L
K
Q
L
I
-
E
E
-
N
D
G
K
R
----
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
S
I
D
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
-
F
Y
D
S
-
D
Q
-----------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
69.35
33%
-79
- C3 -
-
2VSO
1
IF4A_YEAST
A:
[41-378]
--------------------
G
F
E
E
P
-----
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
D
----
T
S
------------------
V
------------------
K
---
A
P
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
----
D
I
K
V
H
A
C
I
G
----------
L
--
R
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
-
R
R
F
R
T
D
K
I
K
--
M
F
I
L
D
E
A
D
-
E
M
L
S
-
S
G
F
K
E
Q
I
Y
Q
I
F
T
L
----
L
----
P
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
-
R
I
L
V
K
K
D
E
L
T
L
-
E
G
I
K
Q
F
Y
V
N
V
--------
E
E
E
----
E
Y
K
Y
E
C
L
-
T
D
-
L
Y
D
S
I
SVT
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
-
F
V
T
N
-
E
D
V
G
A
M
R
E
L
E
---
K
F
----------------------------------------------------------------------------------------
42
PsiBlast_CBE
67.70
31%
1
- C3 -
-
3FHT
3
DD19B_HUMAN
A:
[26-375]
--
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
-----
S
K
I
Q
E
N
A
L
P
L
M
L
A
EP
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
E
----
P
A
------------------
N
------------------
K
---
Y
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
---
Y
P
E
L
K
L
A
Y
A
V
R
G
N
----
K
L
E
R
G
Q
K
I
S
E
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
L
K
F
I
D
P
K
K
I
K
--
V
F
V
L
D
E
A
D
V
M
I
A
T
-
Q
G
H
Q
D
Q
S
I
R
I
Q
R
M
----
L
----
P
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
-
V
I
K
L
K
R
E
E
E
T
L
-
D
T
I
K
Q
Y
Y
V
L
C
-
S
S
R
----
D
E
K
F
Q
A
L
C
N
L
Y
G
A
I
-
T
I
-
A
Q
-------
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
D
K
D
GNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
-
M
-----------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
67.04
31%
2
- C3 -
-
3FHT
5
DD19B_HUMAN
B:
[26-375]
--
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
-----
S
K
I
Q
E
N
A
L
P
L
M
L
A
EP
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
E
----
P
A
------------------
N
------------------
K
---
Y
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
---
Y
P
E
L
K
L
A
Y
A
V
R
G
N
----------
K
I
S
E
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
L
K
F
I
D
P
K
K
I
K
--
V
F
V
L
D
E
A
D
V
M
I
A
T
-
Q
G
H
Q
D
Q
S
I
R
I
Q
R
M
----
L
----
P
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
-
V
I
K
L
K
R
E
E
E
T
L
-
D
T
I
K
Q
Y
Y
V
L
C
-
S
S
R
----
D
E
K
F
Q
A
L
C
N
L
Y
G
A
I
-
T
I
-
A
Q
-------
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
D
K
D
GNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
-
M
-----------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.91
33%
31
- C3 -
-
3PEW
2
DBP5_YEAST
A:
[6-367]
--
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
-----
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
----
P
E
------------------
D
------------------
A
---
S
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
I
T
S
Q
L
I
V
P
D
---
S
F
E
K
N
K
Q
I
N
------
A
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
-
K
L
M
Q
L
Q
K
I
K
--
I
F
V
L
D
E
A
D
-
N
M
L
D
Q
Q
G
L
G
D
Q
C
I
R
V
K
R
F
----
L
----
P
K
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
-
T
L
E
L
Q
T
N
E
V
N
V
-
D
A
I
K
Q
L
Y
M
D
C
-
K
N
E
AD
K
F
D
V
L
----
T
E
L
Y
G
V
M
-
T
I
-
G
S
-------
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQ
A
D
P
A
------
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
-
N
S
F
N
I
L
S
A
I
Q
---
K
-----------------------------------------------------------------------------------------
44
PsiBlast_CBE
65.79
31%
-1
- C3 -
-
3G0H
3
DD19B_HUMAN
A:
[42-391]
--
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
-----
S
K
I
Q
E
N
A
L
P
L
M
L
A
EP
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
E
----
P
A
------------------
N
------------------
K
---
Y
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
---
Y
P
E
L
K
L
A
Y
A
V
R
G
N
----
K
L
E
R
G
Q
K
I
S
E
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
L
K
F
I
D
P
K
K
I
K
--
V
F
V
L
D
E
A
D
V
M
I
A
T
-
Q
G
H
Q
D
Q
S
I
R
I
Q
R
M
----
L
----
P
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
-
V
I
K
L
K
R
E
E
E
T
L
-
D
T
I
K
Q
Y
Y
V
L
C
-
S
S
R
----
D
E
K
F
Q
A
L
C
N
L
Y
G
A
I
-
T
I
-
A
Q
-------
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
D
K
D
GNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
-
M
-----------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
65.72
32%
13
- C3 -
-
2I4I
1
DDX3X_HUMAN
A:
[35-381]
---------------------
Y
T
R
P
-----
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
----
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
------------------
Q
---
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
----
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
-
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
-
G
K
I
G
L
D
F
C
K
--
Y
L
V
L
D
E
A
D
-
R
M
L
D
-
M
G
F
E
P
Q
I
R
R
I
V
E
Q
DT--
M
----
P
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
-
F
L
A
V
G
----
T
S
-
E
N
I
T
Q
K
V
V
W
V
-
E
E
S
----
D
K
R
----
S
F
L
L
D
L
L
N
A
T
-
G
K
D
S
L
----
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
-
F
F
N
---------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
63.21
32%
12
- C3 -
-
5E7J
1
DDX3X_HUMAN
A:
[68-414]
---------------------
Y
T
R
P
-----
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
----
S
D
GPG
E
A
L
R
A
M
K--------
K
------------------
Q
---
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
----
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
-
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
-
G
K
I
G
L
D
F
C
K
--
Y
L
V
L
D
E
A
D
-
R
M
L
D
-
M
G
F
E
P
Q
I
R
R
I
V
E
Q
DT--
M
----
P
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
-
F
L
A
V
G
R
V
G
S
T
S
-
E
N
I
T
Q
K
V
V
W
V
-
E
E
S
----
D
K
R
----
S
F
L
L
D
L
L
N
A
T
-
G
K
D
S
L
----
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
-
F
F
N
---------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
61.11
32%
7
- C3 -
-
5E7M
1
DDX3X_HUMAN
A:
[68-414]
---------------------
Y
T
R
P
-----
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
----
S
D
GPG
E
A
L
R
A
M
KR
R
------
K
------------------
Q
---
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
----
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
-
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
-
G
K
I
G
L
D
F
C
K
--
Y
L
V
L
D
E
A
D
-
R
M
L
D
-
M
G
F
E
P
Q
I
R
R
I
V
E
Q
DT--
M
----
P
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
-
F
L
A
V
G
R
V
G
S
T
S
-
E
N
I
T
Q
K
V
V
W
V
-
E
E
S
----
D
K
R
----
S
F
L
L
D
L
L
N
A
T
-
G
K
D
S
L
----
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
-
F
F
N
---------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
43.63
31%
-19
- C3 -
-
4PX9
1
DDX3X_HUMAN
A:
[85-287]
---------------------
Y
T
R
P
-----
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
----
S
D
GPGEALRAMKENGRYG
R
R
K
------------------
Q
---
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
----
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
-
G
K
I
G
L
D
F
C
K
--
Y
L
V
L
D
E
A
D
-
R
M
L
D
-
M
G
F
E
P
Q
I
R
R
I
V
E
Q
DT--
M
----
P
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
-
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
43.05
31%
-19
- C3 -
-
4PX9
1
DDX3X_HUMAN
C:
[85-287]
---------------------
Y
T
R
P
-----
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
----
S
D
GPGEALRAMKENGRYGRR
K
------------------
Q
---
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
----
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
-
G
K
I
G
L
D
F
C
K
--
Y
L
V
L
D
E
A
D
-
R
M
L
D
-
M
G
F
E
P
Q
I
R
R
I
V
E
Q
DT--
M
----
P
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
-
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
42.76
31%
-17
- C3 -
-
4PX9
1
DDX3X_HUMAN
B:
[85-287]
---------------------
Y
T
R
P
-----
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
----
S
D
GPGEALRAMKENGRYG
R
R
K
------------------
Q
---
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
----
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
-
G
K
I
G
L
D
F
C
K
--
Y
L
V
L
D
E
A
D
-
R
M
L
D
-
M
G
F
E
P
Q
I
R
R
I
V
E
Q
DT--
M
----
P
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
-
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
36.33
32%
16
- C3 -
-
2PL3
4
DDX10_HUMAN
A:
[19-227]
I
N
V
N
E
I
T
R
F
S
D
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
QYRLV
T
E
I
Q
K
Q
T
I
G
L
A
L
Q
--
G
--
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
L
Y
R
L
QW
T
S
------------------
T
------------------
D
---
G
L
G
V
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
G
K
----
N
H
D
F
S
A
G
L
I
I
G
G
--
L
K
H
E
A
E
R
I
N
N
--
I
N
I
L
V
C
T
P
G
R
L
L
Q
H
M
D
E
--
T
V
S
F
H
A
T
D
LQ
M
L
V
L
D
E
A
D
-
R
I
L
D
-
M
G
F
A
D
T
M
N
A
V
I
E
N
----
L
----
P
K
K
--
R
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------