@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXT5: (2018-01-05 )
MSSKELTMYLEKELDQLKEKGLYNTIDILESENGACIIVDGKKMINLASNNYLGFANREELKKACIEATETYGVGAGAVRTINGSLKIHQQLEEKIAEFKGTEAAIAFQSGFNCNMGAISAVMTKEDAILSDELNHASIIDGCRLSGAKIIRIKHQDMKDLEKKAKEAIESKKYKKIMYITDGVFSMDGDIARLPEIIPIVEKYGLITYVDDAHGSGVTGKGAGTVKHFGLSDKIDMQMGTLSKAIGVVGGYVAGSKTLIDWLKARSRPFLFSTSLTPGAAAAALASITLMQEHPELVEKVWENANYFKEELKKVGYNIGMSETPITPVILGDEKVTQTFSKKLIEHGIYAKPIVYPTVPLGTGRIRNMPTAEHTREMLDEAVAVYQKIGKEMEII
Atome Classification :
(27 SA)
.........10........20........30.......-------.-40-----.-------......-..50........60........70........80........90........100---.----.......110.......120-..--.--.....130.......140.-......150.......160.......170.......180.......190.......200.......210.......220-........230.....-..240....-.-.-.250.......260.......270.......280.......290-.--...--....300...--....310.......320.........330.......340...-..-..350.......360.......370.......380.......390....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSS
K
E
L
T
M
Y
L
E
K
E
L
D
Q
L
K
E
KGLY
N
T
I
D
I
L
ESENG
A
C
I
I
-------V-D------G-------
K
K
M
I
N
L-ASNNYLGFA
N
R
E
E
L
K
K
A
C
I
E
A
T
E
TYGVGAG
A
V
R
TING
S
L
K
I
H
Q
Q
L
E
E
K
I
A
E
FKG----T----
E
A
A
I
A
FQSGFNC
N
M
G
A
I
S
A
--
V
M--T--KEDAILSDELNH
A
S
I
IDGC-RLSG
A
K
I
I
R
I
KHQ
D
M
K
D
L
E
K
K
A
K
E
A
I
E
S
KK
Y
K
K
I
M
Y
I
TDGVFSMDG
D
I
A
RL
P
E
I
I
P
I
V
E
KYG
L
I
T
Y
VDDAHGSGVTG-K-GAGT
V
K
HFGLSD
K
I
D
M
-
Q
M
G
T
L
S
K
A
I
-
G
-V-VGGYVAG
S
K
T
L
I
D
W
L
K
ARSR
P
F
L
F
STSLTP
G
A
A
A
A
A
L
A
S
I
T
L
M
--
Q
--E
H
P
--
E
L
V
E
K
V
W
EN
A
--
N
Y
F
K
E
E
L
K
KVGYNIG--MSETPI
T
P
V
I
LG
D
E
K
V
T
Q
T
F
S
K
K
L
I
-EH-GIYAKP
I
V
Y
PTVPLGTGRIRNMP
T
A
E
H
T
R
E
M
L
D
E
A
V
A
V
Y
Q
K
I
G
K
EMEII
73
HHSearch
90.73
41%
-50
- C1 -
-
3A2B
2
?
A:
[15-392]
-------------
V
E
E
L
K
A
K
G
L
Y
A
Y
F
R
P
I
Q
S
K
Q
D
T
E
V
K
-------
I
-
D
------
G
-------
R
R
V
L
M
F
-
G
S
N
S
Y
L
G
L
T
T
D
T
R
I
I
K
A
A
Q
D
A
L
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K
Y
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
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L
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K
L
S
A
Y
V
G
----
K
----
E
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
--
L
M
--
G
--
R
N
D
Y
I
L
L
D
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R
D
H
A
S
I
I
D
G
S
-
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
R
A
K
L
S
R
L
P
---
E
D
S
A
K
L
I
C
T
D
G
I
F
S
M
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G
D
I
V
N
L
P
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L
T
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A
N
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F
D
A
A
V
M
V
D
D
A
H
S
L
G
V
I
G
-
H
K
G
A
G
T
A
S
H
F
G
L
N
D
D
V
D
L
-
I
M
G
T
F
S
K
S
L
-
A
-
S
-
L
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
S
T
L
K
A
L
E
I
I
--
Q
--
N
E
P
--
E
H
I
E
K
L
W
K
N
T
--
D
Y
A
K
A
Q
L
L
D
H
G
F
D
L
G
--
A
T
E
S
P
I
L
P
I
F
I
R
S
N
E
K
T
F
W
V
T
K
M
L
Q
-
D
D
-
G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
M
A
T
H
T
Y
D
Q
I
D
E
A
I
E
K
M
V
K
V
F
K
Q
A
---
59
HHSearch
90.49
42%
-43
* C1 *
-
3TQX
2
?
B:
[4-399]
--
M
Q
E
I
L
S
Q
L
N
K
E
I
E
G
L
K
K
A
G
L
Y
K
S
E
R
I
I
T
S
P
Q
N
A
E
I
K
-------
V
-
G
------
E
-------
K
E
V
L
N
F
-
C
A
N
N
Y
L
G
L
A
D
H
P
A
L
I
K
T
A
Q
T
V
V
E
Q
Y
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
T
I
H
K
E
L
E
K
D
I
S
E
F
L
G
----
T
----
D
D
T
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
--
L
L
--
G
--
P
E
D
A
I
I
S
D
E
L
N
H
A
S
I
I
D
G
I
-
R
L
C
K
A
Q
R
Y
R
Y
K
N
N
A
M
G
D
L
E
A
K
L
K
E
A
D
E
-
K
G
A
R
F
K
L
I
A
T
D
G
V
F
S
M
D
G
I
I
A
D
L
K
S
I
C
D
L
A
D
K
Y
N
A
L
V
M
V
D
D
S
H
A
V
G
F
I
G
-
E
N
G
R
G
T
P
E
Y
C
G
V
A
D
R
V
D
I
-
L
T
G
T
L
G
K
A
L
-
G
-
G
A
S
G
G
Y
T
S
G
H
K
E
I
I
E
W
L
R
N
R
S
R
P
Y
L
F
S
N
T
V
A
P
V
I
V
A
T
S
L
K
V
L
E
L
L
--
K
--
T
E
G
P-
Q
L
R
K
Q
L
Q
E
N
S
--
R
Y
F
R
A
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M
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K
L
G
F
Q
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V
--
P
G
N
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P
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I
P
V
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L
G
D
A
Q
L
A
T
N
M
A
D
H
L
L
-
Q
E
-
G
I
Y
V
V
G
F
S
Y
P
V
V
P
M
G
K
A
R
I
R
V
Q
M
S
A
V
H
T
Q
Q
Q
L
D
R
A
I
E
A
F
G
Q
V
G
K
K
L
G
A
I
1
PsiBlast_PDB
90.43
40%
-49
- C1 -
-
3A2B
2
?
A:
[13-392]
-----------
K
I
V
E
E
L
K
A
K
G
L
Y
A
Y
F
R
P
I
Q
S
K
Q
D
T
E
V
K
-------
I
-
D
------
G
-------
R
R
V
L
M
F
-
G
S
N
S
Y
L
G
L
T
T
D
T
R
I
I
K
A
A
Q
D
A
L
E
K
Y
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
E
L
E
E
K
L
S
A
Y
V
G
----
K
----
E
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
--
L
M
--
G
--
R
N
D
Y
I
L
L
D
E
R
D
H
A
S
I
I
D
G
S
-
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
R
A
K
L
S
R
L
P
E
D
S
A
K
---
L
I
C
T
D
G
I
F
S
M
E
G
D
I
V
N
L
P
E
L
T
S
I
A
N
E
F
D
A
A
V
M
V
D
D
A
H
S
L
G
V
I
G
H
K
-
G
A
G
T
A
S
H
F
G
L
N
D
D
V
D
L
-
I
M
G
T
F
S
K
S
L
-
A
-
S
-
L
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
S
T
L
K
A
L
E
I
I
--
Q
--
N
E
P
--
E
H
I
E
K
L
W
K
N
T
--
D
Y
A
K
A
Q
L
L
D
H
G
F
D
L
G
--
A
T
E
S
P
I
L
P
I
F
I
R
S
N
E
K
T
F
W
V
T
K
M
L
Q
-
D
D
-
G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
M
A
T
H
T
Y
D
Q
I
D
E
A
I
E
K
M
V
K
V
F
K
Q
A
---
2
PsiBlast_PDB
90.37
41%
-44
- C1 -
-
3TQX
2
?
A:
[4-399]
--
M
Q
E
I
L
S
Q
L
N
K
E
I
E
G
L
K
K
A
G
L
Y
K
S
E
R
I
I
T
S
P
Q
N
A
E
I
K
-------
V
-
G
------
E
-------
K
E
V
L
N
F
-
C
A
N
N
Y
L
G
L
A
D
H
P
A
L
I
K
T
A
Q
T
V
V
E
Q
Y
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
T
I
H
K
E
L
E
K
D
I
S
E
F
L
G
----
T
----
D
D
T
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
--
L
L
--
G
--
P
E
D
A
I
I
S
D
E
L
N
H
A
S
I
I
D
G
I
-
R
L
C
K
A
Q
R
Y
R
Y
K
N
N
A
M
G
D
L
E
A
K
L
K
E
A
D
E
K
G
A
R
F
K
L
I
-
A
T
D
G
V
F
S
M
D
G
I
I
A
D
L
K
S
I
C
D
L
A
D
K
Y
N
A
L
V
M
V
D
D
S
H
A
V
G
F
I
G
-
E
N
G
R
G
T
P
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Y
C
G
V
A
D
R
V
D
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L
T
G
T
L
G
K
A
L
G
G
-
A
-
S
G
G
Y
T
S
G
H
K
E
I
I
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W
L
R
N
R
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R
P
Y
L
F
S
N
T
V
A
P
V
I
V
A
T
S
L
K
V
L
E
L
L
--
K
T
-
E
G
P
--
Q
L
R
K
Q
L
Q
E
N
S
--
R
Y
F
R
A
G
M
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K
L
G
F
Q
L
V
--
P
G
N
H
P
I
I
P
V
M
L
G
D
A
Q
L
A
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N
M
A
D
H
L
L
-
Q
E
-
G
I
Y
V
V
G
F
S
Y
P
V
V
P
M
G
K
A
R
I
R
V
Q
M
S
A
V
H
T
Q
Q
Q
L
D
R
A
I
E
A
F
G
Q
V
G
K
K
L
G
A
I
67
HHSearch
89.41
40%
-5
- C1 -
-
1FC4
2
KBL_ECOLI
B:
[6-400]
---
G
E
F
Y
Q
Q
L
T
N
D
L
E
T
A
R
A
E
G
L
F
K
E
E
R
I
I
T
S
A
Q
Q
A
D
I
T
V------
A
-
D
------
G
-------
S
H
V
I
N
F
-
C
A
N
N
Y
L
G
L
A
N
H
P
D
L
I
A
A
A
K
A
G
M
D
S
H
G
F
G
M
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R
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I
C
G
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S
H
K
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L
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K
L
A
A
F
L
G
----
M
----
E
D
A
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
--
L
L
--
G
--
A
E
D
A
I
I
S
D
A
L
N
H
A
S
I
I
D
G
V
-
R
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M
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L
E
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L
K
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A
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A
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V
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G
R
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V
D
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T
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G
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G
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G
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G
G
Y
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K
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Q
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L
F
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S
L
A
P
A
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A
S
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K
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L
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M
V
--
E
--
A
G
S
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Q
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A
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V
A
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K
E
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G
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G
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G
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T
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A
F
T
R
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K
Q
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G
V
I
3
PsiBlast_PDB
88.89
39%
-9
- C1 -
-
1FC4
2
KBL_ECOLI
A:
[7-400]
----
E
F
Y
Q
Q
L
T
N
D
L
E
T
A
R
A
E
G
L
F
K
E
E
R
I
I
T
S
A
Q
Q
A
D
I
T
-------
V
A
D
------
G
-------
S
H
V
I
N
F
-
C
A
N
N
Y
L
G
L
A
N
H
P
D
L
I
A
A
A
K
A
G
M
D
S
H
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
D
S
H
K
E
L
E
Q
K
L
A
A
F
L
G
----
M
----
E
D
A
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
--
L
L
--
G
--
A
E
D
A
I
I
S
D
A
L
N
H
A
S
I
I
D
G
V
-
R
L
C
K
A
K
R
Y
R
Y
A
N
N
D
M
Q
E
L
E
A
R
L
K
E
A
R
E
A
G
A
-
R
H
V
L
I
A
T
D
G
V
F
S
M
D
G
V
I
A
N
L
K
G
V
C
D
L
A
D
K
Y
D
A
L
V
M
V
D
D
S
H
A
V
G
F
V
G
-
E
N
G
R
G
S
H
E
Y
C
D
V
M
G
R
V
D
I
-
I
T
G
T
L
G
K
A
L
-
G
G
A
-
S
G
G
Y
T
A
A
R
K
E
V
V
E
W
L
R
Q
R
S
R
P
Y
L
F
S
N
S
L
A
P
A
I
V
A
A
S
I
K
V
L
E
M
V
--
E
--
A
G
S
--
E
L
R
D
R
L
W
A
N
A
--
R
Q
F
R
E
Q
M
S
A
A
G
F
T
L
A
--
G
A
D
H
A
I
I
P
V
M
L
G
D
A
V
V
A
Q
K
F
A
R
E
L
Q
-
K
E
-
G
I
Y
V
T
G
F
F
Y
P
V
V
P
K
G
Q
A
R
I
R
T
Q
M
S
A
A
H
T
P
E
Q
I
T
R
A
V
E
A
F
T
R
I
G
K
Q
L
G
V
I
66
HHSearch
83.02
32%
-48
- C1 -
-
1BS0
-
BIOF_ECOLI
A:
[2-384]
----
S
W
Q
E
K
I
N
A
A
L
D
A
R
R
A
A
D
A
L
R
R
R
Y
P
V
A
Q
G
A
G
R
W
L
V
-------
A
-
D
------
D
-------
R
Q
Y
L
N
F
-
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
----
Y
----
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
--
M
M
--
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
-
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
----
P
G
Q
Q
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
-
E
Q
G
R
G
S
C
W
L
Q
K
V
--
K
P
E
L
-
L
V
V
T
F
G
K
G
F
-
G
-
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
--
S
D
E
G
D
A
R
R
E
K
L
A
A
L
I
--
T
R
F
R
A
G
V
Q
D
L
P
F
T
L
A
--
D
S
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
-
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
7
PsiBlast_PDB
82.63
34%
-5
- C1 -
-
5JAY
-
BIOF_PARXL
A:
[15-397]
---------
L
A
E
G
L
K
E
I
D
A
R
G
L
R
R
R
R
R
T
A
D
T
P
C
A
A
H
M
T
-------
V
-
D
------
G
-------
R
A
I
I
G
F
-
A
S
N
D
Y
L
G
L
A
A
H
P
Q
L
I
A
A
I
A
E
G
A
Q
R
Y
G
A
G
S
G
-------
H
S
R
A
H
A
Q
L
E
D
D
L
A
E
F
V
G
GFVE
N
----
A
R
A
L
Y
F
S
T
G
Y
M
A
N
L
A
T
L
T
A
--
L
A
--
G
--
R
G
T
T
L
F
S
D
A
L
N
H
A
S
L
I
D
G
A
-
R
L
S
R
A
D
V
Q
I
Y
P
H
C
D
T
D
A
L
S
A
M
----
L
E
A
S
D
A
D
V
K
V
I
V
S
D
T
V
F
S
M
D
G
D
I
A
P
L
P
R
L
L
E
L
A
E
Q
H
G
A
W
L
I
V
D
D
A
H
G
F
G
V
L
G
P
Q
-
G
R
G
A
I
A
Q
A
A
L
R
S
P
N
L
I
-
S
I
G
T
L
D
K
A
A
-
G
-
V
-
S
G
A
F
V
A
A
H
E
T
V
I
E
W
L
V
Q
R
A
R
P
Y
I
F
T
T
A
S
V
P
A
A
A
H
A
V
S
A
S
L
R
I
I
G
G
E
--
E
G
D
--
A
R
R
A
H
L
Q
Q
L
I
--
G
R
T
R
A
M
L
K
A
T
P
W
L
P
V
--
D
S
H
T
A
V
Q
P
L
I
I
G
A
N
D
A
T
L
E
I
A
A
T
L
D
-
R
A
-
G
L
W
V
P
A
I
R
P
P
T
V
P
T
G
T
S
R
L
R
I
S
L
S
A
A
H
S
Q
A
D
L
D
R
L
E
A
G
L
Q
Q
L
-------
50
Fugue
82.38
31%
-46
- C1 -
-
1BS0
-
BIOF_ECOLI
A:
[2-384]
----
S
W
Q
E
K
I
N
A
A
L
D
A
R
R
A
A
D
A
L
R
R
R
Y
P
V
A
Q
G
A
G
R
W
L
V
-------
A
-
D
------
D
-------
R
Q
Y
L
N
F
-
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
----
Y
----
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
--
M
M
--
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
-
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
----
P
C
P
G
Q
Q
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
-
E
Q
G
R
G
S
C
W
L
Q
K
V
--
K
P
E
L
-
L
V
V
T
F
G
K
G
F
-
G
-
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
R
S
D
--
E
G
D
--
A
R
R
E
K
L
A
A
L
I
--
T
R
F
R
A
G
V
Q
D
L
P
F
T
L
A
--
D
S
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
-
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
69
HHSearch
81.90
33%
-14
- C1 -
-
5VNX
4
BIOF_BURM1
C:
[2-392]
----
N
L
L
D
T
L
Q
R
G
L
A
D
L
D
A
Q
G
L
R
R
V
R
R
T
A
D
S
A
C
D
A
H
M
T
-------
V
-
N
------
G
-------
R
E
I
V
G
F
-
A
S
N
D
Y
L
G
L
A
A
H
P
K
L
V
A
A
F
A
E
G
A
Q
R
Y
G
S
G
S
G
G
S
H
L
L
G
G
H
S
R
A
H
A
K
L
E
D
E
L
A
G
F
A
G
----
G
FSD
A
P
R
A
L
Y
F
S
T
G
Y
M
A
N
L
A
A
V
T
A
--
L
A
--
G
--
K
D
A
T
I
F
S
D
A
L
N
H
A
S
L
I
D
G
T
-
R
L
S
R
A
T
V
Q
V
Y
P
H
A
D
T
A
T
L
G
A
L
L
E
A
C
T
----
S
Q
T
K
L
I
V
T
D
T
V
F
S
M
D
G
D
I
A
P
L
A
E
L
L
A
L
A
E
R
H
G
A
W
L
V
V
D
D
A
H
G
F
G
V
L
G
-
P
Q
G
R
G
A
L
A
A
A
A
L
R
S
P
H
L
V
-
Y
V
G
T
L
G
-
A
A
-
G
-
V
-
A
G
A
F
V
V
A
H
E
T
V
I
E
W
L
I
Q
R
A
R
S
Y
I
F
T
T
A
A
P
P
A
V
A
H
A
V
S
A
S
L
K
V
I
--
A
--
G
D
E
G
D
A
R
R
A
H
L
A
A
L
I
--
E
R
T
R
A
L
L
R
R
T
R
W
Q
P
V
--
D
S
H
T
A
V
Q
P
L
V
I
G
S
N
E
A
T
L
A
A
M
R
A
L
D
-
A
H
-
G
L
W
V
P
A
I
R
P
P
T
V
P
A
G
T
S
R
L
R
I
S
L
S
A
A
H
S
F
D
D
L
A
R
L
E
T
A
L
L
R
A
S
E
E
----
49
Fugue
81.84
34%
11
- C1 -
-
2BWN
2
HEM1_RHOCB
A:
[2-397]
----
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
K
-------
A
-
Q
------
W
NRPDG
G
K
Q
D
I
T
V
W
-
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
----
K
----
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
--
L
R
--
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
-
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
---
D
D
P
A
A
P
K
L
I
A
F
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
-
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
-
F
N
G
T
L
A
K
A
Y
-
G
-
V
-
F
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
K
T
A
--
E
G
Q
--
K
L
R
D
A
Q
Q
M
H
A
--
K
V
L
K
M
R
L
K
A
L
G
M
P
I
I
--
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
-
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
------
68
HHSearch
81.18
33%
-13
- C1 -
-
5VNX
7
BIOF_BURM1
A:
[2-392]
----
N
L
L
D
T
L
Q
R
G
L
A
D
L
D
A
Q
G
L
R
R
V
R
R
T
A
D
S
A
C
D
A
H
M
T
-------
V
-
N
------
G
-------
R
E
I
V
G
F
-
A
S
N
D
Y
L
G
L
A
A
H
P
K
L
V
A
A
F
A
E
G
A
Q
R
Y
G
S
G
S
G
G
S
H
L
L
G
G
H
S
R
A
H
A
K
L
E
D
E
L
A
G
F
A
G
----
G
FSD
A
P
R
A
L
Y
F
S
T
G
Y
M
A
N
L
A
A
V
T
A
--
L
A
--
G
--
K
D
A
T
I
F
S
D
A
L
N
H
A
S
L
I
D
G
T
-
R
L
S
R
A
T
V
Q
V
Y
P
H
A
D
T
A
T
L
G
A
L
L
E
A
C
T
----
S
Q
T
K
L
I
V
T
D
T
V
F
S
M
D
G
D
I
A
P
L
A
E
L
L
A
L
A
E
R
H
G
A
W
L
V
V
D
D
A
H
G
F
G
V
L
G
-
P
Q
G
R
G
A
L
A
A
A
A
L
R
S
P
H
L
V
-
Y
V
G
T
L
G
-
A
A
-
G
-
V
-
A
G
A
F
V
V
A
H
E
T
V
I
E
W
L
I
Q
R
A
R
S
Y
I
F
T
T
A
A
P
P
A
V
A
H
A
V
S
A
S
L
K
V
I
--
A
--
G
D
E
G
D
A
R
R
A
H
L
A
A
L
I
--
E
R
T
R
A
L
L
R
R
T
R
W
Q
P
V
--
D
S
H
T
A
V
Q
P
L
V
I
G
S
N
E
A
T
L
A
A
M
R
A
L
D
-
A
H
-
G
L
W
V
P
A
I
R
P
P
T
V
P
A
G
T
S
R
L
R
I
S
L
S
A
A
H
S
F
D
D
L
A
R
L
E
T
A
L
L
R
A
S
E
E
----
60
HHSearch
80.52
34%
12
- C1 -
-
2BWN
3
HEM1_RHOCB
E:
[2-399]
----
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
K
AQWNRPD
G
-
G
------
K
-------
Q
D
I
T
V
W
-
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
----
K
----
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
--
L
R
VL
F
--
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
-
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
---
P
A
A
P
K
L
I
A
F
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
-
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
-
F
N
G
T
L
A
K
A
Y
-
G
-
V
-
F
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
--
T
A
E
GQ
K
L
R
D
A
Q
Q
M
H
A
--
K
V
L
K
M
R
L
K
A
L
G
M
P
I
I
--
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
-
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
A
R
----
61
HHSearch
80.28
34%
11
- C1 -
-
2BWO
5
HEM1_RHOCB
E:
[2-399]
----
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
K
AQWNRPD
G
-
G
------
K
-------
Q
D
I
T
V
W
-
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
----
K
----
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
--
L
R
VL
F
--
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
-
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
---
P
A
A
P
K
L
I
A
F
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
-
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
-
F
N
G
T
L
A
K
A
Y
-
G
-
V
-
F
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
--
T
A
E
GQ
K
L
R
D
A
Q
Q
M
H
A
--
K
V
L
K
M
R
L
K
A
L
G
M
P
I
I
--
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
-
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
A
R
----
19
PsiBlast_PDB
80.15
33%
-52
- C1 -
-
2G6W
1
BIOF_ECOLI
A:
[31-384]
---------------------------------
G
R
W
L
V
-------
A
-
D
------
D
-------
R
Q
Y
L
N
F
-
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
----
Y
----
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
--
M
M
--
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
-
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
P
G
Q
Q
----
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
-
G
R
G
S
C
--
W
L
Q
K
V
K
P
E
L
-
L
V
V
T
F
G
K
G
F
-
G
-
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
E
G
D
--
A
R
R
E
K
L
A
A
L
I
--
T
R
F
R
A
G
V
Q
D
L
P
F
T
L
A
--
D
S
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
-
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
65
HHSearch
79.97
31%
-55
- C1 -
-
1DJE
1
BIOF_ECOLI
A:
[3-384]
-----
W
Q
E
K
I
N
A
A
L
D
A
R
G
A
A
D
A
L
R
R
R
Y
P
V
A
Q
G
A
G
R
W
L
V
-------
A
-
D
------
D
-------
R
Q
Y
L
N
F
-
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
----
Y
----
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
--
M
M
--
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
-
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
----
P
G
Q
Q
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
-
E
Q
G
R
G
S
C
W
L
Q
K
V
--
K
P
E
L
-
L
V
V
T
F
G
K
G
F
-
G
-
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
--
S
D
E
G
D
A
R
R
E
K
L
A
A
L
I
--
T
R
F
R
A
G
V
Q
D
L
P
F
T
L
A
--
D
S
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
-
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
6
PsiBlast_PDB
79.85
36%
6
- C1 -
-
2BWN
2
HEM1_RHOCB
A:
[2-390]
----
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
K
-------
A
-
Q
W
NRPDG
G
-------
K
Q
D
I
T
V
W
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
----
K
----
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
--
F
--
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
-
F
R
H
N
D
V
A
H
L
-
R
E
L
I
A
A
D
D
P
A
A
P
K
L
I
A
F
--
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
-
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
-
F
N
G
T
L
A
K
A
Y
-
G
-
V
-
F
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
E
G
Q
--
K
L
R
D
A
Q
Q
M
H
A
--
K
V
L
K
M
R
L
K
A
L
G
M
P
I
I
--
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
-
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
-------------
18
PsiBlast_PDB
79.67
33%
-51
- C1 -
-
1BS0
-
BIOF_ECOLI
A:
[31-384]
---------------------------------
G
R
W
L
V
-------
A
-
D
------
D
-------
R
Q
Y
L
N
F
-
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
----
Y
----
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
--
M
M
--
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
-
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
P
G
Q
Q
----
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
-
G
R
G
S
C
--
W
L
Q
K
V
K
P
E
L
-
L
V
V
T
F
G
K
G
F
-
G
-
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
E
G
D
--
A
R
R
E
K
L
A
A
L
I
--
T
R
F
R
A
G
V
Q
D
L
P
F
T
L
A
--
D
S
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
-
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
22
PsiBlast_CBE
79.47
36%
4
- C1 -
-
2BWP
4
HEM1_RHOCB
D:
[2-390]
----
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
K
-------
A
-
Q
WNRPDG
G
-------
K
Q
D
I
T
V
W
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
----
K
----
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
LR
V
L
--
F
--
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
-
F
R
H
N
D
V
A
H
L
-
R
E
L
I
A
A
D
D
P
A
A
P
K
L
I
A
F
--
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
-
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
-
F
N
G
T
L
A
K
A
Y
-
G
-
V
-
F
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
TA
E
G
Q
--
K
L
R
D
A
Q
Q
M
H
A
--
K
V
L
K
M
R
L
K
A
L
G
M
P
I
I
--
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
-
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
-------------
24
PsiBlast_CBE
79.27
36%
7
- C1 -
-
2BWO
5
HEM1_RHOCB
E:
[2-390]
----
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
K
-------
A
-
Q
WNRPDG
G
-------
K
Q
D
I
T
V
W
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
----
K
----
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
LR
V
L
--
F
--
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
-
F
R
H
N
D
V
A
H
L
-
R
E
L
I
A
A
D
D
P
A
A
P
K
L
I
A
F
--
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
-
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
-
F
N
G
T
L
A
K
A
Y
-
G
-
V
-
F
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
TA
E
G
Q
--
K
L
R
D
A
Q
Q
M
H
A
--
K
V
L
K
M
R
L
K
A
L
G
M
P
I
I
--
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
-
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
-------------
12
PsiBlast_PDB
79.24
32%
-65
- C1 -
-
2XBN
1
?
A:
[60-418]
-------------------------------------
V
-------
I
-
R
------
G
-------
K
D
T
I
L
L
-
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
----
T
----
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
--
L
A
--
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
-
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
---
P
K
E
P
A
K
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
-
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
-
V
V
G
T
F
S
K
S
V
-
G
-
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
--
T
A
H
--
E
K
R
E
R
L
W
S
N
A
--
R
A
L
H
G
G
L
K
A
M
G
F
R
L
G
TE
T
C
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
31
PsiBlast_CBE
77.88
32%
-57
- C1 -
-
1DJE
1
BIOF_ECOLI
A:
[31-384]
---------------------------------
G
R
W
L
V
-------
A
-
D
------
D
-------
R
Q
Y
L
N
F
-
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
----
Y
----
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
--
M
M
--
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
-
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
P
G
Q
Q
----
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
-
G
R
G
S
C
--
W
L
Q
K
V
K
P
E
L
-
L
V
V
T
F
G
K
G
F
-
G
-
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
E
G
D
--
A
R
R
E
K
L
A
A
L
I
--
T
R
F
R
A
G
V
Q
D
L
P
F
T
L
A
--
D
S
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
-
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
20
PsiBlast_PDB
77.86
32%
-52
- C1 -
-
1DJ9
1
BIOF_ECOLI
A:
[31-384]
---------------------------------
G
R
W
L
V
-------
A
-
D
------
D
-------
R
Q
Y
L
N
F
-
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
----
Y
----
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
--
M
M
--
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
-
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
P
G
Q
Q
----
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
-
G
R
G
S
C
--
W
L
Q
K
V
K
P
E
L
-
L
V
V
T
F
G
K
G
F
-
G
-
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
E
G
D
--
A
R
R
E
K
L
A
A
L
I
--
T
R
F
R
A
G
V
Q
D
L
P
F
T
L
A
--
D
S
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
-
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
26
PsiBlast_CBE
77.49
32%
-65
- C1 -
-
4BMK
4
?
B:
[82-438]
-------------------------------------
V
-------
I
-
R
------
G
-------
K
D
T
I
L
L
-
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
----
T
----
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
--
L
A
--
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
-
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
---
P
K
E
P
A
K
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
-
G
R
G
V
Y
E
A
Q
G
L
E
G
Q
I
D
F
-
V
V
G
T
F
S
A
S
V
-
G
-
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
--
T
A
H
--
E
K
R
E
R
L
W
S
N
A
--
R
A
L
H
G
G
L
K
A
M
G
F
R
L
G
TE
T
C
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
-
G
L
Y
V
N
M
A
----------
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
--
33
PsiBlast_CBE
75.74
32%
-7
- C1 -
-
5VNX
5
BIOF_BURM1
B:
[7-379]
---------
L
Q
R
G
L
A
D
L
D
A
Q
G
L
R
R
V
R
R
T
A
D
S
A
C
D
A
H
M
T
-------
V
-
N
------
G
-------
R
E
I
V
G
F
-
A
S
N
D
Y
L
G
L
A
A
H
P
K
L
V
A
A
F
A
E
G
A
Q
R
Y
G
S
G
S
G
G
S
H
L
L
G
G
H
S
R
A
H
A
K
L
E
D
E
L
A
G
F
A
G
GFSD
A
----
P
R
A
L
Y
F
S
T
G
Y
M
A
N
L
A
A
V
T
A
--
L
A
--
G
--
K
D
A
T
I
F
S
D
A
L
N
H
A
S
L
I
D
G
T
-
R
L
S
R
A
T
V
Q
V
Y
P
H
A
D
T
A
T
L
----
G
A
L
L
E
A
C
T
S
Q
T
K
L
I
V
T
D
T
V
F
S
M
D
G
D
I
A
P
L
A
-
L
L
A
L
A
E
R
H
G
A
W
L
V
V
D
D
A
H
G
F
G
V
L
G
-
P
-
Q
G
R
G
A
L
A
A
A
A
L
R
S
P
H
L
V
Y
V
G
T
L
G
A
A
--
G
-
V
-
A
G
A
F
V
V
A
H
E
T
V
I
E
W
L
I
Q
R
A
R
S
Y
I
F
T
T
A
A
P
P
A
V
A
H
A
V
S
A
S
L
K
V
I
--
A
--
G
D
E
--
G
D
A
R
R
A
H
L
A
A
L
I
E
R
T
R
A
L
L
R
R
T
R
W
Q
P
V
--
D
S
H
T
A
V
Q
P
L
V
I
G
S
N
E
A
T
L
A
A
M
R
A
L
D
-
A
H
-
G
L
W
V
P
A
I
R
P
P
T
V
P
A
G
T
S
R
L
R
I
S
L
S
A
A
H
S
F
D
D
L
-----------------
32
PsiBlast_CBE
75.13
32%
-7
- C1 -
-
5VNX
4
BIOF_BURM1
C:
[7-379]
---------
L
Q
R
G
L
A
D
L
D
A
Q
G
L
R
R
V
R
R
T
A
D
S
A
C
D
A
H
M
T
-------
V
-
N
------
G
-------
R
E
I
V
G
F
-
A
S
N
D
Y
L
G
L
A
A
H
P
K
L
V
A
A
F
A
E
G
A
Q
R
Y
G
S
G
S
G
G
S
H
L
L
G
G
H
S
R
A
H
A
K
L
E
D
E
L
A
G
F
A
G
GFSD
A
----
P
R
A
L
Y
F
S
T
G
Y
M
A
N
L
A
A
V
T
A
--
L
A
--
G
--
K
D
A
T
I
F
S
D
A
L
N
H
A
S
L
I
D
G
T
-
R
L
S
R
A
T
V
Q
V
Y
P
H
A
D
T
A
T
L
----
G
A
L
L
E
A
C
T
S
Q
T
K
L
I
V
T
D
T
V
F
S
M
D
G
D
I
A
P
L
A
E
L
L
A
L
A
E
R
H
G
A
W
L
V
V
D
D
A
H
G
F
G
V
L
G
-
P
-
Q
G
R
G
A
L
A
A
A
A
L
R
S
P
H
L
V
Y
V
G
T
L
G
A
A
--
G
-
V
-
A
G
A
F
V
V
A
H
E
T
V
I
E
W
L
I
Q
R
A
R
S
Y
I
F
T
T
A
A
P
P
A
V
A
H
A
V
S
A
S
L
K
V
I
--
A
--
G
D
E
--
G
D
A
R
R
A
H
L
A
A
L
I
E
R
T
R
A
L
L
R
R
T
R
W
Q
P
V
--
D
S
H
T
A
V
Q
P
L
V
I
G
S
N
E
A
T
L
A
A
M
R
A
L
D
-
A
H
-
G
L
W
V
P
A
I
R
P
P
T
V
P
A
G
T
S
R
L
R
I
S
L
S
A
A
H
S
F
D
D
L
-----------------
34
PsiBlast_CBE
74.63
32%
-6
- C1 -
-
5VNX
7
BIOF_BURM1
A:
[7-379]
---------
L
Q
R
G
L
A
D
L
D
A
Q
G
L
R
R
V
R
R
T
A
D
S
A
C
D
A
H
M
T
-------
V
-
N
------
G
-------
R
E
I
V
G
F
-
A
S
N
D
Y
L
G
L
A
A
H
P
K
L
V
A
A
F
A
E
G
A
Q
R
Y
G
S
G
S
G
G
S
H
L
L
G
G
H
S
R
A
H
A
K
L
E
D
E
L
A
G
F
A
G
GFSD
A
----
P
R
A
L
Y
F
S
T
G
Y
M
A
N
L
A
A
V
T
A
--
L
A
--
G
--
K
D
A
T
I
F
S
D
A
L
N
H
A
S
L
I
D
G
T
-
R
L
S
R
A
T
V
Q
V
Y
P
H
A
D
T
A
T
L
----
G
A
L
L
E
A
C
T
S
Q
T
K
L
I
V
T
D
T
V
F
S
M
D
G
D
I
A
P
L
A
E
L
L
A
L
A
E
R
H
G
A
W
L
V
V
D
D
A
H
G
F
G
V
L
G
-
P
-
Q
G
R
G
A
L
A
A
A
A
L
R
S
P
H
L
V
Y
V
G
T
L
G
A
A
--
G
-
V
-
A
G
A
F
V
V
A
H
E
T
V
I
E
W
L
I
Q
R
A
R
S
Y
I
F
T
T
A
A
P
P
A
V
A
H
A
V
S
A
S
L
K
V
I
--
A
--
G
D
E
--
G
D
A
R
R
A
H
L
A
A
L
I
E
R
T
R
A
L
L
R
R
T
R
W
Q
P
V
--
D
S
H
T
A
V
Q
P
L
V
I
G
S
N
E
A
T
L
A
A
M
R
A
L
D
-
A
H
-
G
L
W
V
P
A
I
R
P
P
T
V
P
A
G
T
S
R
L
R
I
S
L
S
A
A
H
S
F
D
D
L
-----------------